AGIOAGIOS PHARMACEUTICALS, INC.
- Market cap
- $2.21B
- as of 2026-10-23
- Latest close
- $37.00
- as of 2026-10-23
- Sector
- Healthcare
- as of 2026-10-24
- Industry
- Biotechnology
- as of 2026-10-24
Cluster
No cluster in the last 90 days under the default rule (14d · ≥2 insiders · all roles).
Form 4 historysince 2024-01-05
Showing the latest 500 of 510 transactions.
| Insider | Traded | Filed | Type | Shares | Price | Value | Owned after | 10b5-1 plan | Filing |
|---|---|---|---|---|---|---|---|---|---|
| Gheuens SarahChief Medical Officer | Oct 22 | Oct 23 | M | 500 | $25.01 | $12,505 | 55,145 | Yes | Form 4 |
| Gheuens SarahChief Medical Officer | Oct 22 | Oct 23 | S | 500 | $37.52 | Sale −$18,760 | 54,645 | Yes | Form 4 |
| Gheuens SarahChief Medical Officer | Oct 22 | Oct 23 | M · derivative | 500 | $25.01 | $12,505 | 24,141 | Yes | Form 4 |
| Gheuens SarahChief Medical Officer | Oct 21 | Oct 23 | M | 1,489 | $25.01 | $37,240 | 56,134 | Yes | Form 4 |
| Gheuens SarahChief Medical Officer | Oct 21 | Oct 23 | S | 1,489 | $37.53 | Sale −$55,882 | 54,645 | Yes | Form 4 |
| Gheuens SarahChief Medical Officer | Oct 21 | Oct 23 | M · derivative | 1,489 | $25.01 | $37,240 | 24,641 | Yes | Form 4 |
| Gheuens SarahChief Medical Officer | Aug 4 | Aug 6 | S | 30,000 | $30.48 | Sale −$914,400 | 54,645 | Yes | Form 4 |
| Backstrom Jay T. | Jul 8 | Jul 10 | A | 1,447 | $0.00 | $0 | 1,447 | No | Form 4 |
| Backstrom Jay T. | Jul 8 | Jul 10 | M · derivative | 1,447 | $0.00 | $0 | 2,894 | No | Form 4 |
| Gheuens SarahChief Medical Officer | Jul 1 | Jul 2 | M | 8,375 | $0.00 | $0 | 88,652 | Yes | Form 4 |
| Gheuens SarahChief Medical Officer | Jul 1 | Jul 2 | S | 4,007 | $37.56 | Sale −$150,503 | 84,645 | Yes | Form 4 |
| Gheuens SarahChief Medical Officer | Jul 1 | Jul 2 | M · derivative | 8,375 | $0.00 | $0 | not reported | Yes | Form 4 |
| Backstrom Jay T. | Jun 18 | Jun 23 | A · derivative | 2,927 | $0.00 | $0 | 2,927 | No | Form 4 |
| Backstrom Jay T. | Jun 18 | Jun 23 | A · derivative | 14,950 | $34.16 | $510,692 | 14,950 | No | Form 4 |
| Milanova TsvetaChief Commercial Officer | Jun 18 | Jun 23 | M · derivative | 3,000 | $0.00 | $0 | 9,000 | No | Form 4 |
| Milanova TsvetaChief Commercial Officer | Jun 18 | Jun 23 | A · derivative | 3,000 | $0.00 | $0 | 3,000 | No | Form 4 |
| Jones CeciliaChief Financial Officer | Jun 18 | Jun 23 | M · derivative | 3,000 | $0.00 | $0 | 9,000 | No | Form 4 |
| Jones CeciliaChief Financial Officer | Jun 18 | Jun 23 | A · derivative | 3,000 | $0.00 | $0 | 3,000 | No | Form 4 |
| Gheuens SarahChief Medical Officer | Jun 18 | Jun 23 | M · derivative | 3,000 | $0.00 | $0 | 9,000 | No | Form 4 |
| Gheuens SarahChief Medical Officer | Jun 18 | Jun 23 | A · derivative | 3,000 | $0.00 | $0 | 3,000 | No | Form 4 |
| Burns James WilliamChief Legal Officer | Jun 18 | Jun 23 | M · derivative | 3,000 | $0.00 | $0 | 9,000 | No | Form 4 |
| Burns James WilliamChief Legal Officer | Jun 18 | Jun 23 | A · derivative | 3,000 | $0.00 | $0 | 3,000 | No | Form 4 |
| Goff BrianChief Executive Officer | Jun 18 | Jun 23 | M · derivative | 39,000 | $0.00 | $0 | 39,000 | No | Form 4 |
| Goff BrianChief Executive Officer | Jun 18 | Jun 23 | A · derivative | 39,000 | $0.00 | $0 | 39,000 | No | Form 4 |
| Viswanadhan KrishnanChief Strategy and Operations | Jun 18 | Jun 23 | M · derivative | 3,000 | $0.00 | $0 | 9,000 | No | Form 4 |
| Viswanadhan KrishnanChief Strategy and Operations | Jun 18 | Jun 23 | A · derivative | 3,000 | $0.00 | $0 | 3,000 | No | Form 4 |
| Smith Cynthia | Jun 18 | Jun 23 | M | 2,816 | $0.00 | $0 | 15,230 | No | Form 4 |
| Smith Cynthia | Jun 18 | Jun 23 | M · derivative | 2,816 | $0.00 | $0 | not reported | No | Form 4 |
| Smith Cynthia | Jun 18 | Jun 23 | A · derivative | 2,927 | $0.00 | $0 | 2,927 | No | Form 4 |
| Smith Cynthia | Jun 18 | Jun 23 | A · derivative | 14,950 | $34.16 | $510,692 | 14,950 | No | Form 4 |
| Scadden David | Jun 18 | Jun 23 | M | 2,816 | $0.00 | $0 | 20,419 | No | Form 4 |
| Scadden David | Jun 18 | Jun 23 | M · derivative | 2,816 | $0.00 | $0 | not reported | No | Form 4 |
| Scadden David | Jun 18 | Jun 23 | A · derivative | 2,927 | $0.00 | $0 | 2,927 | No | Form 4 |
| Scadden David | Jun 18 | Jun 23 | A · derivative | 14,950 | $34.16 | $510,692 | 14,950 | No | Form 4 |
| Owen Adams Catherine | Jun 18 | Jun 23 | M | 2,816 | $0.00 | $0 | 10,865 | No | Form 4 |
| Owen Adams Catherine | Jun 18 | Jun 23 | M · derivative | 2,816 | $0.00 | $0 | not reported | No | Form 4 |
| Owen Adams Catherine | Jun 18 | Jun 23 | A · derivative | 2,927 | $0.00 | $0 | 2,927 | No | Form 4 |
| Owen Adams Catherine | Jun 18 | Jun 23 | A · derivative | 14,950 | $34.16 | $510,692 | 14,950 | No | Form 4 |
| Ho Maykin | Jun 18 | Jun 23 | M | 2,816 | $0.00 | $0 | 19,848 | No | Form 4 |
| Ho Maykin | Jun 18 | Jun 23 | M · derivative | 2,816 | $0.00 | $0 | not reported | No | Form 4 |
| Ho Maykin | Jun 18 | Jun 23 | A · derivative | 2,927 | $0.00 | $0 | 2,927 | No | Form 4 |
| Ho Maykin | Jun 18 | Jun 23 | A · derivative | 14,950 | $34.16 | $510,692 | 14,950 | No | Form 4 |
| Fouse Jacqualyn A | Jun 18 | Jun 23 | M | 2,816 | $0.00 | $0 | 154,156 | No | Form 4 |
| Fouse Jacqualyn A | Jun 18 | Jun 23 | M · derivative | 2,816 | $0.00 | $0 | not reported | No | Form 4 |
| Fouse Jacqualyn A | Jun 18 | Jun 23 | A · derivative | 2,927 | $0.00 | $0 | 2,927 | No | Form 4 |
| Fouse Jacqualyn A | Jun 18 | Jun 23 | A · derivative | 14,950 | $34.16 | $510,692 | 14,950 | No | Form 4 |
| Foster-Cheek Kaye I | Jun 18 | Jun 23 | M | 2,816 | $0.00 | $0 | 10,284 | No | Form 4 |
| Foster-Cheek Kaye I | Jun 18 | Jun 23 | M · derivative | 2,816 | $0.00 | $0 | not reported | No | Form 4 |
| Foster-Cheek Kaye I | Jun 18 | Jun 23 | A · derivative | 2,927 | $0.00 | $0 | 2,927 | No | Form 4 |
| Foster-Cheek Kaye I | Jun 18 | Jun 23 | A · derivative | 14,950 | $34.16 | $510,692 | 14,950 | No | Form 4 |
| Capello Jeffrey D | Jun 18 | Jun 23 | M | 2,816 | $0.00 | $0 | 10,865 | No | Form 4 |
| Capello Jeffrey D | Jun 18 | Jun 23 | M · derivative | 2,816 | $0.00 | $0 | not reported | No | Form 4 |
| Capello Jeffrey D | Jun 18 | Jun 23 | A · derivative | 2,927 | $0.00 | $0 | 2,927 | No | Form 4 |
| Capello Jeffrey D | Jun 18 | Jun 23 | A · derivative | 14,950 | $34.16 | $510,692 | 14,950 | No | Form 4 |
| Ballal Rahul D. | Jun 18 | Jun 23 | M | 2,816 | $0.00 | $0 | 15,230 | No | Form 4 |
| Ballal Rahul D. | Jun 18 | Jun 23 | M · derivative | 2,816 | $0.00 | $0 | not reported | No | Form 4 |
| Ballal Rahul D. | Jun 18 | Jun 23 | A · derivative | 2,927 | $0.00 | $0 | 2,927 | No | Form 4 |
| Ballal Rahul D. | Jun 18 | Jun 23 | A · derivative | 14,950 | $34.16 | $510,692 | 14,950 | No | Form 4 |
| Capello Jeffrey D | Jun 13 | Jun 16 | M | 1,976 | $0.00 | $0 | 8,049 | No | Form 4 |
| Capello Jeffrey D | Jun 13 | Jun 16 | M · derivative | 1,976 | $0.00 | $0 | not reported | No | Form 4 |
| Owen Adams Catherine | Jun 13 | Jun 16 | M | 1,976 | $0.00 | $0 | 8,049 | No | Form 4 |
| Owen Adams Catherine | Jun 13 | Jun 16 | M · derivative | 1,976 | $0.00 | $0 | not reported | No | Form 4 |
| Goff BrianChief Executive Officer | Apr 2 | Apr 6 | M | 25,528 | $0.00 | $0 | 190,076 | Yes | Form 4 |
| Goff BrianChief Executive Officer | Apr 2 | Apr 6 | S | 12,472 | $34.71 | Sale −$432,903 | 177,604 | Yes | Form 4 |
| Goff BrianChief Executive Officer | Apr 2 | Apr 6 | M | 13,500 | $0.00 | $0 | 191,104 | Yes | Form 4 |
| Goff BrianChief Executive Officer | Apr 2 | Apr 6 | S | 6,596 | $34.71 | Sale −$228,947 | 184,508 | Yes | Form 4 |
| Goff BrianChief Executive Officer | Apr 2 | Apr 6 | M · derivative | 25,528 | $0.00 | $0 | not reported | Yes | Form 4 |
| Goff BrianChief Executive Officer | Apr 2 | Apr 6 | M · derivative | 13,500 | $0.00 | $0 | 40,500 | Yes | Form 4 |
| Viswanadhan KrishnanChief Corp Dev & Strategy | Apr 2 | Apr 6 | M | 8,100 | $0.00 | $0 | 13,241 | Yes | Form 4 |
| Viswanadhan KrishnanChief Corp Dev & Strategy | Apr 2 | Apr 6 | S | 2,959 | $34.71 | Sale −$102,707 | 10,282 | Yes | Form 4 |
| Viswanadhan KrishnanChief Corp Dev & Strategy | Apr 2 | Apr 6 | M · derivative | 8,100 | $0.00 | $0 | 8,100 | Yes | Form 4 |
| Milanova TsvetaChief Commercial Officer | Apr 2 | Apr 6 | M | 8,500 | $0.00 | $0 | 50,091 | Yes | Form 4 |
| Milanova TsvetaChief Commercial Officer | Apr 2 | Apr 6 | S | 3,262 | $34.71 | Sale −$113,224 | 46,829 | Yes | Form 4 |
| Milanova TsvetaChief Commercial Officer | Apr 2 | Apr 6 | M · derivative | 8,500 | $0.00 | $0 | 8,500 | Yes | Form 4 |
| Jones CeciliaChief Financial Officer | Apr 2 | Apr 6 | M | 8,500 | $0.00 | $0 | 58,139 | Yes | Form 4 |
| Jones CeciliaChief Financial Officer | Apr 2 | Apr 6 | S | 3,141 | $34.71 | Sale −$109,024 | 54,998 | Yes | Form 4 |
| Jones CeciliaChief Financial Officer | Apr 2 | Apr 6 | M · derivative | 8,500 | $0.00 | $0 | 8,500 | Yes | Form 4 |
| Gheuens SarahChief Medical Officer | Apr 2 | Apr 6 | M | 8,500 | $0.00 | $0 | 83,217 | Yes | Form 4 |
| Gheuens SarahChief Medical Officer | Apr 2 | Apr 6 | S | 2,940 | $34.71 | Sale −$102,047 | 80,277 | Yes | Form 4 |
| Gheuens SarahChief Medical Officer | Apr 2 | Apr 6 | M · derivative | 8,500 | $0.00 | $0 | 8,500 | Yes | Form 4 |
| Burns James WilliamChief Legal Officer | Apr 2 | Apr 6 | M | 8,500 | $0.00 | $0 | 52,586 | Yes | Form 4 |
| Burns James WilliamChief Legal Officer | Apr 2 | Apr 6 | S | 3,280 | $34.71 | Sale −$113,849 | 49,306 | Yes | Form 4 |
| Burns James WilliamChief Legal Officer | Apr 2 | Apr 6 | M · derivative | 8,500 | $0.00 | $0 | 8,500 | Yes | Form 4 |
| Viswanadhan KrishnanChief Corp Dev & Strategy | Mar 5 | Mar 9 | M | 8,100 | $0.00 | $0 | 8,100 | Yes | Form 4 |
| Viswanadhan KrishnanChief Corp Dev & Strategy | Mar 5 | Mar 9 | S | 2,959 | $27.80 | Sale −$82,260 | 5,141 | Yes | Form 4 |
| Viswanadhan KrishnanChief Corp Dev & Strategy | Mar 5 | Mar 9 | M · derivative | 8,100 | $0.00 | $0 | 16,200 | Yes | Form 4 |
| Washburn Theodore James Jr.Principal Accounting Officer | Mar 3 | Mar 5 | S | 5,272 | $28.88 | Sale −$152,255 | 868 | No | Form 4 |
| Washburn Theodore James Jr.Principal Accounting Officer | Mar 2 | Mar 3 | M | 2,350 | $0.00 | $0 | 3,293 | Yes | Form 4 |
| Washburn Theodore James Jr.Principal Accounting Officer | Mar 2 | Mar 3 | S | 698 | $28.96 | Sale −$20,214 | 2,595 | Yes | Form 4 |
| Washburn Theodore James Jr.Principal Accounting Officer | Mar 2 | Mar 3 | M | 2,450 | $0.00 | $0 | 4,970 | Yes | Form 4 |
| Washburn Theodore James Jr.Principal Accounting Officer | Mar 2 | Mar 3 | S | 727 | $28.96 | Sale −$21,054 | 4,243 | Yes | Form 4 |
| Washburn Theodore James Jr.Principal Accounting Officer | Mar 2 | Mar 3 | M | 2,695 | $0.00 | $0 | 6,938 | Yes | Form 4 |
| Washburn Theodore James Jr.Principal Accounting Officer | Mar 2 | Mar 3 | S | 798 | $28.96 | Sale −$23,110 | 6,140 | Yes | Form 4 |
| Washburn Theodore James Jr.Principal Accounting Officer | Mar 2 | Mar 3 | M · derivative | 2,350 | $0.00 | $0 | not reported | Yes | Form 4 |
| Washburn Theodore James Jr.Principal Accounting Officer | Mar 2 | Mar 3 | M · derivative | 2,450 | $0.00 | $0 | 2,450 | Yes | Form 4 |
| Washburn Theodore James Jr.Principal Accounting Officer | Mar 2 | Mar 3 | M · derivative | 2,695 | $0.00 | $0 | 5,390 | Yes | Form 4 |
| Milanova TsvetaChief Commercial Officer | Mar 2 | Mar 3 | M | 5,666 | $0.00 | $0 | 40,459 | Yes | Form 4 |
| Milanova TsvetaChief Commercial Officer | Mar 2 | Mar 3 | S | 1,681 | $28.96 | Sale −$48,682 | 38,778 | Yes | Form 4 |
| Milanova TsvetaChief Commercial Officer | Mar 2 | Mar 3 | M | 4,000 | $0.00 | $0 | 42,778 | Yes | Form 4 |
| Milanova TsvetaChief Commercial Officer | Mar 2 | Mar 3 | S | 1,187 | $28.96 | Sale −$34,376 | 41,591 | Yes | Form 4 |
| Milanova TsvetaChief Commercial Officer | Mar 2 | Mar 3 | M · derivative | 5,666 | $0.00 | $0 | 5,667 | Yes | Form 4 |
| Milanova TsvetaChief Commercial Officer | Mar 2 | Mar 3 | M · derivative | 4,000 | $0.00 | $0 | 8,000 | Yes | Form 4 |
| Jones CeciliaChief Financial Officer | Mar 2 | Mar 3 | M | 2,000 | $0.00 | $0 | 39,394 | Yes | Form 4 |
| Jones CeciliaChief Financial Officer | Mar 2 | Mar 3 | S | 594 | $28.96 | Sale −$17,202 | 38,800 | Yes | Form 4 |
| Jones CeciliaChief Financial Officer | Mar 2 | Mar 3 | M | 5,666 | $0.00 | $0 | 44,466 | Yes | Form 4 |
| Jones CeciliaChief Financial Officer | Mar 2 | Mar 3 | S | 1,681 | $28.96 | Sale −$48,682 | 42,785 | Yes | Form 4 |
| Jones CeciliaChief Financial Officer | Mar 2 | Mar 3 | M | 4,000 | $0.00 | $0 | 46,785 | Yes | Form 4 |
| Jones CeciliaChief Financial Officer | Mar 2 | Mar 3 | S | 1,187 | $28.96 | Sale −$34,376 | 45,598 | Yes | Form 4 |
| Jones CeciliaChief Financial Officer | Mar 2 | Mar 3 | M | 5,303 | $0.00 | $0 | 50,901 | Yes | Form 4 |
| Jones CeciliaChief Financial Officer | Mar 2 | Mar 3 | S | 1,573 | $28.96 | Sale −$45,554 | 49,328 | Yes | Form 4 |
| Jones CeciliaChief Financial Officer | Mar 2 | Mar 3 | M · derivative | 2,000 | $0.00 | $0 | not reported | Yes | Form 4 |
| Jones CeciliaChief Financial Officer | Mar 2 | Mar 3 | M · derivative | 5,666 | $0.00 | $0 | 5,667 | Yes | Form 4 |
| Jones CeciliaChief Financial Officer | Mar 2 | Mar 3 | M · derivative | 4,000 | $0.00 | $0 | 8,000 | Yes | Form 4 |
| Jones CeciliaChief Financial Officer | Mar 2 | Mar 3 | M · derivative | 5,303 | $0.00 | $0 | 10,607 | Yes | Form 4 |
| Gheuens SarahChief Medical Officer | Mar 2 | Mar 3 | M | 4,000 | $0.00 | $0 | 68,795 | Yes | Form 4 |
| Gheuens SarahChief Medical Officer | Mar 2 | Mar 3 | S | 1,187 | $28.96 | Sale −$34,376 | 67,608 | Yes | Form 4 |
| Gheuens SarahChief Medical Officer | Mar 2 | Mar 3 | M | 5,666 | $0.00 | $0 | 73,274 | Yes | Form 4 |
| Gheuens SarahChief Medical Officer | Mar 2 | Mar 3 | S | 1,681 | $28.96 | Sale −$48,682 | 71,593 | Yes | Form 4 |
| Gheuens SarahChief Medical Officer | Mar 2 | Mar 3 | M | 4,000 | $0.00 | $0 | 75,593 | Yes | Form 4 |
| Gheuens SarahChief Medical Officer | Mar 2 | Mar 3 | S | 1,187 | $28.96 | Sale −$34,376 | 74,406 | Yes | Form 4 |
| Gheuens SarahChief Medical Officer | Mar 2 | Mar 3 | M · derivative | 4,000 | $0.00 | $0 | not reported | Yes | Form 4 |
| Gheuens SarahChief Medical Officer | Mar 2 | Mar 3 | M · derivative | 5,666 | $0.00 | $0 | 5,667 | Yes | Form 4 |
| Gheuens SarahChief Medical Officer | Mar 2 | Mar 3 | M · derivative | 4,000 | $0.00 | $0 | 8,000 | Yes | Form 4 |
| Burns James WilliamChief Legal Officer | Mar 2 | Mar 3 | M | 4,000 | $0.00 | $0 | 35,718 | Yes | Form 4 |
| Burns James WilliamChief Legal Officer | Mar 2 | Mar 3 | S | 1,187 | $28.96 | Sale −$34,376 | 34,531 | Yes | Form 4 |
| Burns James WilliamChief Legal Officer | Mar 2 | Mar 3 | M | 5,666 | $0.00 | $0 | 40,197 | Yes | Form 4 |
| Burns James WilliamChief Legal Officer | Mar 2 | Mar 3 | S | 1,681 | $28.96 | Sale −$48,682 | 38,516 | Yes | Form 4 |
| Burns James WilliamChief Legal Officer | Mar 2 | Mar 3 | M | 4,000 | $0.00 | $0 | 42,516 | Yes | Form 4 |
| Burns James WilliamChief Legal Officer | Mar 2 | Mar 3 | S | 1,187 | $28.96 | Sale −$34,376 | 41,329 | Yes | Form 4 |
| Burns James WilliamChief Legal Officer | Mar 2 | Mar 3 | M | 3,920 | $0.00 | $0 | 45,249 | Yes | Form 4 |
| Burns James WilliamChief Legal Officer | Mar 2 | Mar 3 | S | 1,163 | $28.96 | Sale −$33,680 | 44,086 | Yes | Form 4 |
| Burns James WilliamChief Legal Officer | Mar 2 | Mar 3 | M · derivative | 4,000 | $0.00 | $0 | not reported | Yes | Form 4 |
| Burns James WilliamChief Legal Officer | Mar 2 | Mar 3 | M · derivative | 5,666 | $0.00 | $0 | 5,667 | Yes | Form 4 |
| Burns James WilliamChief Legal Officer | Mar 2 | Mar 3 | M · derivative | 4,000 | $0.00 | $0 | 8,000 | Yes | Form 4 |
| Burns James WilliamChief Legal Officer | Mar 2 | Mar 3 | M · derivative | 3,920 | $0.00 | $0 | 7,839 | Yes | Form 4 |
| Goff BrianChief Executive Officer | Mar 2 | Mar 3 | M | 8,500 | $0.00 | $0 | 151,603 | Yes | Form 4 |
| Goff BrianChief Executive Officer | Mar 2 | Mar 3 | S | 3,870 | $28.96 | Sale −$112,075 | 147,733 | Yes | Form 4 |
| Goff BrianChief Executive Officer | Mar 2 | Mar 3 | M | 18,000 | $0.00 | $0 | 165,733 | Yes | Form 4 |
| Goff BrianChief Executive Officer | Mar 2 | Mar 3 | S | 8,267 | $28.96 | Sale −$239,412 | 157,466 | Yes | Form 4 |
| Goff BrianChief Executive Officer | Mar 2 | Mar 3 | M | 13,000 | $0.00 | $0 | 170,466 | Yes | Form 4 |
| Goff BrianChief Executive Officer | Mar 2 | Mar 3 | S | 5,918 | $28.96 | Sale −$171,385 | 164,548 | Yes | Form 4 |
| Goff BrianChief Executive Officer | Mar 2 | Mar 3 | M · derivative | 8,500 | $0.00 | $0 | not reported | Yes | Form 4 |
| Goff BrianChief Executive Officer | Mar 2 | Mar 3 | M · derivative | 18,000 | $0.00 | $0 | 18,000 | Yes | Form 4 |
| Goff BrianChief Executive Officer | Mar 2 | Mar 3 | M · derivative | 13,000 | $0.00 | $0 | 26,000 | Yes | Form 4 |
| Viswanadhan KrishnanChief Corp Dev & Strategy | Mar 1 | Mar 3 | A · derivative | 14,000 | $0.00 | $0 | 14,000 | Yes | Form 4 |
| Viswanadhan KrishnanChief Corp Dev & Strategy | Mar 1 | Mar 3 | A · derivative | 52,000 | $30.23 | $1,571,960 | 52,000 | Yes | Form 4 |
| Washburn Theodore James Jr.Principal Accounting Officer | Mar 1 | Mar 3 | A · derivative | 8,452 | $0.00 | $0 | 8,452 | Yes | Form 4 |
| Milanova TsvetaChief Commercial Officer | Mar 1 | Mar 3 | A · derivative | 14,000 | $0.00 | $0 | 14,000 | Yes | Form 4 |
| Milanova TsvetaChief Commercial Officer | Mar 1 | Mar 3 | A · derivative | 52,000 | $30.23 | $1,571,960 | 52,000 | Yes | Form 4 |
| Jones CeciliaChief Financial Officer | Mar 1 | Mar 3 | A · derivative | 14,000 | $0.00 | $0 | 14,000 | Yes | Form 4 |
| Jones CeciliaChief Financial Officer | Mar 1 | Mar 3 | A · derivative | 52,000 | $30.23 | $1,571,960 | 52,000 | Yes | Form 4 |
| Gheuens SarahChief Medical Officer | Mar 1 | Mar 3 | A · derivative | 14,000 | $0.00 | $0 | 14,000 | Yes | Form 4 |
| Gheuens SarahChief Medical Officer | Mar 1 | Mar 3 | A · derivative | 22,000 | $0.00 | $0 | 22,000 | Yes | Form 4 |
| Gheuens SarahChief Medical Officer | Mar 1 | Mar 3 | A · derivative | 52,000 | $30.23 | $1,571,960 | 52,000 | Yes | Form 4 |
| Burns James WilliamChief Legal Officer | Mar 1 | Mar 3 | A · derivative | 14,000 | $0.00 | $0 | 14,000 | Yes | Form 4 |
| Burns James WilliamChief Legal Officer | Mar 1 | Mar 3 | A · derivative | 52,000 | $30.23 | $1,571,960 | 52,000 | Yes | Form 4 |
| Goff BrianChief Executive Officer | Mar 1 | Mar 3 | A · derivative | 48,000 | $0.00 | $0 | 48,000 | Yes | Form 4 |
| Goff BrianChief Executive Officer | Mar 1 | Mar 3 | A · derivative | 174,000 | $30.23 | $5,260,020 | 174,000 | Yes | Form 4 |
| Milanova TsvetaChief Commercial Officer | Jan 5 | Jan 7 | M | 8,475 | $0.00 | $0 | 37,665 | Yes | Form 4 |
| Milanova TsvetaChief Commercial Officer | Jan 5 | Jan 7 | S | 2,872 | $27.02 | Sale −$77,601 | 34,793 | Yes | Form 4 |
| Milanova TsvetaChief Commercial Officer | Jan 5 | Jan 7 | M · derivative | 8,475 | $0.00 | $0 | not reported | Yes | Form 4 |
| Jones CeciliaChief Financial Officer | Dec 30, 2025 | Jan 2 | M | 6,000 | $0.00 | $0 | 40,326 | Yes | Form 4 |
| Jones CeciliaChief Financial Officer | Dec 30, 2025 | Jan 2 | S | 2,932 | $27.09 | Sale −$79,428 | 37,394 | Yes | Form 4 |
| Jones CeciliaChief Financial Officer | Dec 30, 2025 | Jan 2 | M · derivative | 6,000 | $0.00 | $0 | not reported | Yes | Form 4 |
| Milanova TsvetaChief Commercial Officer | Dec 30, 2025 | Jan 2 | M | 6,000 | $0.00 | $0 | 32,122 | Yes | Form 4 |
| Milanova TsvetaChief Commercial Officer | Dec 30, 2025 | Jan 2 | S | 2,932 | $27.09 | Sale −$79,428 | 29,190 | Yes | Form 4 |
| Milanova TsvetaChief Commercial Officer | Dec 30, 2025 | Jan 2 | M · derivative | 6,000 | $0.00 | $0 | not reported | Yes | Form 4 |
| Gheuens SarahChief Medical Officer | Dec 30, 2025 | Jan 2 | M | 6,000 | $0.00 | $0 | 67,727 | Yes | Form 4 |
| Gheuens SarahChief Medical Officer | Dec 30, 2025 | Jan 2 | S | 2,932 | $27.09 | Sale −$79,428 | 64,795 | Yes | Form 4 |
| Gheuens SarahChief Medical Officer | Dec 30, 2025 | Jan 2 | M · derivative | 6,000 | $0.00 | $0 | not reported | Yes | Form 4 |
| Goff BrianChief Executive Officer | Dec 30, 2025 | Jan 2 | M | 25,528 | $0.00 | $0 | 149,056 | Yes | Form 4 |
| Goff BrianChief Executive Officer | Dec 30, 2025 | Jan 2 | S | 12,473 | $27.09 | Sale −$337,894 | 136,583 | Yes | Form 4 |
| Goff BrianChief Executive Officer | Dec 30, 2025 | Jan 2 | M | 12,750 | $0.00 | $0 | 149,333 | Yes | Form 4 |
| Goff BrianChief Executive Officer | Dec 30, 2025 | Jan 2 | S | 6,230 | $27.09 | Sale −$168,771 | 143,103 | Yes | Form 4 |
| Goff BrianChief Executive Officer | Dec 30, 2025 | Jan 2 | M · derivative | 25,528 | $0.00 | $0 | 25,528 | Yes | Form 4 |
| Goff BrianChief Executive Officer | Dec 30, 2025 | Jan 2 | M · derivative | 12,750 | $0.00 | $0 | not reported | Yes | Form 4 |
| Burns James WilliamChief Legal Officer | Dec 30, 2025 | Jan 2 | M | 6,000 | $0.00 | $0 | 34,650 | Yes | Form 4 |
| Burns James WilliamChief Legal Officer | Dec 30, 2025 | Jan 2 | S | 2,932 | $27.09 | Sale −$79,428 | 31,718 | Yes | Form 4 |
| Burns James WilliamChief Legal Officer | Dec 30, 2025 | Jan 2 | M · derivative | 6,000 | $0.00 | $0 | not reported | Yes | Form 4 |
| Scadden David | Nov 12, 2025 | Nov 14, 2025 | M | 200 | $18.09 | $3,618 | 17,803 | Yes | Form 4 |
| Scadden David | Nov 12, 2025 | Nov 14, 2025 | S | 200 | $43.84 | Sale −$8,768 | 17,603 | Yes | Form 4 |
| Scadden David | Nov 12, 2025 | Nov 14, 2025 | M · derivative | 200 | $18.09 | $3,618 | 26,907 | Yes | Form 4 |
| Gheuens SarahChief Medical Officer | Nov 11, 2025 | Nov 13, 2025 | M | 2,454 | $25.01 | $61,375 | 64,181 | Yes | Form 4 |
| Gheuens SarahChief Medical Officer | Nov 11, 2025 | Nov 13, 2025 | S | 2,454 | $43.78 | Sale −$107,436 | 61,727 | Yes | Form 4 |
| Gheuens SarahChief Medical Officer | Nov 11, 2025 | Nov 13, 2025 | M · derivative | 2,454 | $25.01 | $61,375 | 26,130 | Yes | Form 4 |
| Gheuens SarahChief Medical Officer | Oct 30, 2025 | Nov 3, 2025 | M | 200 | $25.01 | $5,002 | 61,927 | Yes | Form 4 |
| Gheuens SarahChief Medical Officer | Oct 30, 2025 | Nov 3, 2025 | S | 200 | $43.81 | Sale −$8,762 | 61,727 | Yes | Form 4 |
| Gheuens SarahChief Medical Officer | Oct 30, 2025 | Nov 3, 2025 | M · derivative | 200 | $25.01 | $5,002 | 28,584 | Yes | Form 4 |
| Gheuens SarahChief Medical Officer | Oct 27, 2025 | Oct 29, 2025 | M | 3,302 | $25.01 | $82,583 | 65,029 | Yes | Form 4 |
| Gheuens SarahChief Medical Officer | Oct 27, 2025 | Oct 29, 2025 | S | 3,302 | $43.92 | Sale −$145,024 | 61,727 | Yes | Form 4 |
| Gheuens SarahChief Medical Officer | Oct 27, 2025 | Oct 29, 2025 | M · derivative | 3,302 | $25.01 | $82,583 | 28,784 | Yes | Form 4 |
| Scadden David | Oct 8, 2025 | Oct 10, 2025 | M | 200 | $18.09 | $3,618 | 17,803 | Yes | Form 4 |
| Scadden David | Oct 8, 2025 | Oct 10, 2025 | S | 200 | $41.00 | Sale −$8,200 | 17,603 | Yes | Form 4 |
| Scadden David | Oct 8, 2025 | Oct 10, 2025 | M · derivative | 200 | $18.09 | $3,618 | 27,107 | Yes | Form 4 |
| Scadden David | Sep 30, 2025 | Oct 2, 2025 | M | 200 | $18.09 | $3,618 | 17,803 | Yes | Form 4 |
| Scadden David | Sep 30, 2025 | Oct 2, 2025 | S | 200 | $40.00 | Sale −$8,000 | 17,603 | Yes | Form 4 |
| Scadden David | Sep 30, 2025 | Oct 2, 2025 | M · derivative | 200 | $18.09 | $3,618 | 27,307 | Yes | Form 4 |
| Jones CeciliaChief Financial Officer | Sep 26, 2025 | Sep 30, 2025 | M | 7,472 | $0.00 | $0 | 37,521 | Yes | Form 4 |
| Jones CeciliaChief Financial Officer | Sep 26, 2025 | Sep 30, 2025 | S | 3,651 | $36.77 | Sale −$134,247 | 33,870 | Yes | Form 4 |
| Jones CeciliaChief Financial Officer | Sep 26, 2025 | Sep 30, 2025 | M · derivative | 7,472 | $0.00 | $0 | not reported | Yes | Form 4 |
| Washburn Theodore James Jr.Principal Accounting Officer | Sep 5, 2025 | Sep 9, 2025 | S | 8,546 | $36.87 | Sale −$315,091 | 868 | No | Form 4 |
| Scadden David | Aug 27, 2025 | Aug 29, 2025 | M | 200 | $18.09 | $3,618 | 17,803 | Yes | Form 4 |
| Scadden David | Aug 27, 2025 | Aug 29, 2025 | S | 200 | $40.00 | Sale −$8,000 | 17,603 | Yes | Form 4 |
| Scadden David | Aug 27, 2025 | Aug 29, 2025 | M · derivative | 200 | $18.09 | $3,618 | 27,507 | Yes | Form 4 |
| Smith Cynthia | Aug 11, 2025 | Aug 13, 2025 | M | 2,302 | $0.00 | $0 | 12,414 | No | Form 4 |
| Smith Cynthia | Aug 11, 2025 | Aug 13, 2025 | M · derivative | 2,302 | $0.00 | $0 | not reported | No | Form 4 |
| Ballal Rahul D. | Aug 11, 2025 | Aug 13, 2025 | M | 2,302 | $0.00 | $0 | 12,414 | No | Form 4 |
| Ballal Rahul D. | Aug 11, 2025 | Aug 13, 2025 | M · derivative | 2,302 | $0.00 | $0 | not reported | No | Form 4 |
| Goff BrianChief Executive Officer | Aug 8, 2025 | Aug 12, 2025 | M | 22,691 | $0.00 | $0 | 134,613 | Yes | Form 4 |
| Goff BrianChief Executive Officer | Aug 8, 2025 | Aug 12, 2025 | S | 11,085 | $36.67 | Sale −$406,487 | 123,528 | Yes | Form 4 |
| Goff BrianChief Executive Officer | Aug 8, 2025 | Aug 12, 2025 | M · derivative | 22,691 | $0.00 | $0 | not reported | Yes | Form 4 |
| Scadden David | Jul 10, 2025 | Jul 15, 2025 | M | 1,400 | $18.09 | $25,326 | 19,003 | Yes | Form 4 |
| Scadden David | Jul 10, 2025 | Jul 15, 2025 | S | 1,400 | $40.00 | Sale −$56,000 | 17,603 | Yes | Form 4 |
| Scadden David | Jul 10, 2025 | Jul 15, 2025 | M · derivative | 1,400 | $18.09 | $25,326 | 27,707 | Yes | Form 4 |
| Gheuens SarahChief Medical Officer | Jul 9, 2025 | Jul 11, 2025 | M | 11,914 | $25.01 | $297,969 | 73,185 | Yes | Form 4 |
| Gheuens SarahChief Medical Officer | Jul 9, 2025 | Jul 11, 2025 | S | 11,067 | $37.93 | Sale −$419,771 | 62,118 | Yes | Form 4 |
| Gheuens SarahChief Medical Officer | Jul 9, 2025 | Jul 11, 2025 | S | 847 | $38.76 | Sale −$32,830 | 61,271 | Yes | Form 4 |
| Gheuens SarahChief Medical Officer | Jul 9, 2025 | Jul 11, 2025 | M · derivative | 11,914 | $25.01 | $297,969 | 32,086 | Yes | Form 4 |
| Backstrom Jay T. | Jul 8, 2025 | Jul 10, 2025 | A · derivative | 23,393 | $36.28 | $848,698 | 23,393 | No | Form 4 |
| Backstrom Jay T. | Jul 8, 2025 | Jul 10, 2025 | A · derivative | 4,341 | $0.00 | $0 | 4,341 | No | Form 4 |
| Gheuens SarahChief Medical Officer | Jul 1, 2025 | Jul 3, 2025 | M | 8,374 | $0.00 | $0 | 65,362 | Yes | Form 4 |
| Gheuens SarahChief Medical Officer | Jul 1, 2025 | Jul 3, 2025 | S | 4,091 | $34.17 | Sale −$139,789 | 61,271 | Yes | Form 4 |
| Gheuens SarahChief Medical Officer | Jul 1, 2025 | Jul 3, 2025 | M · derivative | 8,374 | $0.00 | $0 | 8,375 | Yes | Form 4 |
| Goff BrianChief Executive Officer | Jun 24, 2025 | Jun 26, 2025 | M | 25,527 | $0.00 | $0 | 117,872 | Yes | Form 4 |
| Goff BrianChief Executive Officer | Jun 24, 2025 | Jun 26, 2025 | S | 12,471 | $33.54 | Sale −$418,277 | 105,401 | Yes | Form 4 |
| Goff BrianChief Executive Officer | Jun 24, 2025 | Jun 26, 2025 | M | 12,750 | $0.00 | $0 | 118,151 | Yes | Form 4 |
| Goff BrianChief Executive Officer | Jun 24, 2025 | Jun 26, 2025 | S | 6,229 | $33.54 | Sale −$208,921 | 111,922 | Yes | Form 4 |
| Goff BrianChief Executive Officer | Jun 24, 2025 | Jun 26, 2025 | M · derivative | 25,527 | $0.00 | $0 | 51,056 | Yes | Form 4 |
| Goff BrianChief Executive Officer | Jun 24, 2025 | Jun 26, 2025 | M · derivative | 12,750 | $0.00 | $0 | 12,750 | Yes | Form 4 |
| Milanova TsvetaChief Commercial Officer | Jun 24, 2025 | Jun 26, 2025 | M | 6,000 | $0.00 | $0 | 28,892 | Yes | Form 4 |
| Milanova TsvetaChief Commercial Officer | Jun 24, 2025 | Jun 26, 2025 | S | 2,770 | $33.54 | Sale −$92,906 | 26,122 | Yes | Form 4 |
| Milanova TsvetaChief Commercial Officer | Jun 24, 2025 | Jun 26, 2025 | M · derivative | 6,000 | $0.00 | $0 | 6,000 | Yes | Form 4 |
| Jones CeciliaChief Financial Officer | Jun 24, 2025 | Jun 26, 2025 | M | 6,000 | $0.00 | $0 | 31,829 | Yes | Form 4 |
| Jones CeciliaChief Financial Officer | Jun 24, 2025 | Jun 26, 2025 | S | 1,780 | $33.54 | Sale −$59,701 | 30,049 | Yes | Form 4 |
| Jones CeciliaChief Financial Officer | Jun 24, 2025 | Jun 26, 2025 | M · derivative | 6,000 | $0.00 | $0 | 6,000 | Yes | Form 4 |
| Gheuens SarahChief Medical Officer | Jun 24, 2025 | Jun 26, 2025 | M | 6,000 | $0.00 | $0 | 59,897 | Yes | Form 4 |
| Gheuens SarahChief Medical Officer | Jun 24, 2025 | Jun 26, 2025 | S | 2,909 | $33.54 | Sale −$97,568 | 56,988 | Yes | Form 4 |
| Gheuens SarahChief Medical Officer | Jun 24, 2025 | Jun 26, 2025 | M · derivative | 6,000 | $0.00 | $0 | 6,000 | Yes | Form 4 |
| Burns James WilliamChief Legal Officer | Jun 24, 2025 | Jun 26, 2025 | M | 6,000 | $0.00 | $0 | 31,449 | Yes | Form 4 |
| Burns James WilliamChief Legal Officer | Jun 24, 2025 | Jun 26, 2025 | S | 2,799 | $33.54 | Sale −$93,878 | 28,650 | Yes | Form 4 |
| Burns James WilliamChief Legal Officer | Jun 24, 2025 | Jun 26, 2025 | M · derivative | 6,000 | $0.00 | $0 | 6,000 | Yes | Form 4 |
| Smith Cynthia | Jun 20, 2025 | Jun 23, 2025 | M | 2,120 | $0.00 | $0 | 10,112 | No | Form 4 |
| Smith Cynthia | Jun 20, 2025 | Jun 23, 2025 | M · derivative | 2,120 | $0.00 | $0 | not reported | No | Form 4 |
| Scadden David | Jun 20, 2025 | Jun 23, 2025 | M | 2,120 | $0.00 | $0 | 17,603 | No | Form 4 |
| Scadden David | Jun 20, 2025 | Jun 23, 2025 | M · derivative | 2,120 | $0.00 | $0 | not reported | No | Form 4 |
| Owen Adams Catherine | Jun 20, 2025 | Jun 23, 2025 | M | 2,120 | $0.00 | $0 | 6,073 | No | Form 4 |
| Owen Adams Catherine | Jun 20, 2025 | Jun 23, 2025 | M · derivative | 2,120 | $0.00 | $0 | not reported | No | Form 4 |
| Ho Maykin | Jun 20, 2025 | Jun 23, 2025 | M | 2,120 | $0.00 | $0 | 17,032 | No | Form 4 |
| Ho Maykin | Jun 20, 2025 | Jun 23, 2025 | M · derivative | 2,120 | $0.00 | $0 | not reported | No | Form 4 |
| Fouse Jacqualyn A | Jun 20, 2025 | Jun 23, 2025 | M | 2,120 | $0.00 | $0 | 151,340 | No | Form 4 |
| Fouse Jacqualyn A | Jun 20, 2025 | Jun 23, 2025 | M · derivative | 2,120 | $0.00 | $0 | not reported | No | Form 4 |
| Foster-Cheek Kaye I | Jun 20, 2025 | Jun 23, 2025 | M | 2,120 | $0.00 | $0 | 7,468 | No | Form 4 |
| Foster-Cheek Kaye I | Jun 20, 2025 | Jun 23, 2025 | M · derivative | 2,120 | $0.00 | $0 | not reported | No | Form 4 |
| Capello Jeffrey D | Jun 20, 2025 | Jun 23, 2025 | M | 2,120 | $0.00 | $0 | 6,073 | No | Form 4 |
| Capello Jeffrey D | Jun 20, 2025 | Jun 23, 2025 | M · derivative | 2,120 | $0.00 | $0 | not reported | No | Form 4 |
| Ballal Rahul D. | Jun 20, 2025 | Jun 23, 2025 | M | 2,120 | $0.00 | $0 | 10,112 | No | Form 4 |
| Ballal Rahul D. | Jun 20, 2025 | Jun 23, 2025 | M · derivative | 2,120 | $0.00 | $0 | not reported | No | Form 4 |
| Smith Cynthia | Jun 18, 2025 | Jun 23, 2025 | A · derivative | 2,816 | $0.00 | $0 | 2,816 | No | Form 4 |
| Smith Cynthia | Jun 18, 2025 | Jun 23, 2025 | A · derivative | 15,768 | $35.50 | $559,764 | 15,768 | No | Form 4 |
| Scadden David | Jun 18, 2025 | Jun 23, 2025 | A · derivative | 2,816 | $0.00 | $0 | 2,816 | No | Form 4 |
| Scadden David | Jun 18, 2025 | Jun 23, 2025 | A · derivative | 15,768 | $35.50 | $559,764 | 15,768 | No | Form 4 |
| Owen Adams Catherine | Jun 18, 2025 | Jun 23, 2025 | A · derivative | 2,816 | $0.00 | $0 | 2,816 | No | Form 4 |
| Owen Adams Catherine | Jun 18, 2025 | Jun 23, 2025 | A · derivative | 15,768 | $35.50 | $559,764 | 15,768 | No | Form 4 |
| Ho Maykin | Jun 18, 2025 | Jun 23, 2025 | A · derivative | 2,816 | $0.00 | $0 | 2,816 | No | Form 4 |
| Ho Maykin | Jun 18, 2025 | Jun 23, 2025 | A · derivative | 15,768 | $35.50 | $559,764 | 15,768 | No | Form 4 |
| Fouse Jacqualyn A | Jun 18, 2025 | Jun 23, 2025 | A · derivative | 2,816 | $0.00 | $0 | 2,816 | No | Form 4 |
| Fouse Jacqualyn A | Jun 18, 2025 | Jun 23, 2025 | A · derivative | 15,768 | $35.50 | $559,764 | 15,768 | No | Form 4 |
| Foster-Cheek Kaye I | Jun 18, 2025 | Jun 23, 2025 | A · derivative | 2,816 | $0.00 | $0 | 2,816 | No | Form 4 |
| Foster-Cheek Kaye I | Jun 18, 2025 | Jun 23, 2025 | A · derivative | 15,768 | $35.50 | $559,764 | 15,768 | No | Form 4 |
| Capello Jeffrey D | Jun 18, 2025 | Jun 23, 2025 | A · derivative | 2,861 | $0.00 | $0 | 2,861 | No | Form 4 |
| Capello Jeffrey D | Jun 18, 2025 | Jun 23, 2025 | A · derivative | 15,768 | $35.50 | $559,764 | 15,768 | No | Form 4 |
| Ballal Rahul D. | Jun 18, 2025 | Jun 23, 2025 | A · derivative | 2,816 | $0.00 | $0 | 2,816 | No | Form 4 |
| Ballal Rahul D. | Jun 18, 2025 | Jun 23, 2025 | A · derivative | 15,768 | $35.50 | $559,764 | 15,768 | No | Form 4 |
| Owen Adams Catherine | Jun 13, 2025 | Jun 17, 2025 | M | 1,977 | $0.00 | $0 | 3,953 | No | Form 4 |
| Owen Adams Catherine | Jun 13, 2025 | Jun 17, 2025 | M · derivative | 1,977 | $0.00 | $0 | 1,976 | No | Form 4 |
| Capello Jeffrey D | Jun 13, 2025 | Jun 17, 2025 | M | 1,977 | $0.00 | $0 | 3,953 | No | Form 4 |
| Capello Jeffrey D | Jun 13, 2025 | Jun 17, 2025 | M · derivative | 1,977 | $0.00 | $0 | 1,976 | No | Form 4 |
| Fouse Jacqualyn A | Apr 10, 2025 | Apr 10, 2025 | S | 7,497 | $25.90 | Sale −$194,172 | 149,220 | Yes | Form 4 |
| Fouse Jacqualyn A | Apr 8, 2025 | Apr 10, 2025 | M | 15,933 | $0.00 | $0 | 156,717 | Yes | Form 4 |
| Fouse Jacqualyn A | Apr 8, 2025 | Apr 10, 2025 | M · derivative | 15,933 | $0.00 | $0 | not reported | Yes | Form 4 |
| Viswanadhan KrishnanChief Corp Dev & Strategy | Mar 5, 2025 | Mar 7, 2025 | A · derivative | 24,300 | $0.00 | $0 | 24,300 | No | Form 4 |
| Viswanadhan KrishnanChief Corp Dev & Strategy | Mar 5, 2025 | Mar 7, 2025 | A · derivative | 55,374 | $33.95 | $1,879,947 | 55,374 | No | Form 4 |
| Washburn Theodore James Jr.Principal Accounting Officer | Mar 3, 2025 | Mar 4, 2025 | S | 231 | $35.54 | Sale −$8,210 | 6,038 | Yes | Form 4 |
| Washburn Theodore James Jr.Principal Accounting Officer | Mar 3, 2025 | Mar 4, 2025 | S | 697 | $35.54 | Sale −$24,771 | 7,691 | Yes | Form 4 |
| Washburn Theodore James Jr.Principal Accounting Officer | Mar 3, 2025 | Mar 4, 2025 | S | 727 | $35.54 | Sale −$25,838 | 9,414 | Yes | Form 4 |
| Washburn Theodore James Jr.Principal Accounting Officer | Mar 3, 2025 | Mar 4, 2025 | M · derivative | 2,450 | $0.00 | $0 | 4,900 | Yes | Form 4 |
| Gheuens SarahChief Medical Officer | Mar 3, 2025 | Mar 4, 2025 | S | 1,137 | $35.54 | Sale −$40,409 | 47,098 | Yes | Form 4 |
| Gheuens SarahChief Medical Officer | Mar 3, 2025 | Mar 4, 2025 | S | 1,187 | $35.54 | Sale −$42,186 | 49,911 | Yes | Form 4 |
| Gheuens SarahChief Medical Officer | Mar 3, 2025 | Mar 4, 2025 | S | 1,681 | $35.54 | Sale −$59,743 | 53,897 | Yes | Form 4 |
| Goff BrianChief Executive Officer | Mar 3, 2025 | Mar 4, 2025 | S | 4,153 | $35.54 | Sale −$147,598 | 83,139 | Yes | Form 4 |
| Goff BrianChief Executive Officer | Mar 3, 2025 | Mar 4, 2025 | S | 8,794 | $35.54 | Sale −$312,539 | 92,345 | Yes | Form 4 |
| Milanova TsvetaChief Commercial Officer | Mar 3, 2025 | Mar 4, 2025 | S | 1,681 | $35.54 | Sale −$59,743 | 22,892 | Yes | Form 4 |
| Jones CeciliaChief Financial Officer | Mar 3, 2025 | Mar 4, 2025 | S | 594 | $35.54 | Sale −$21,111 | 21,843 | Yes | Form 4 |
| Jones CeciliaChief Financial Officer | Mar 3, 2025 | Mar 4, 2025 | S | 1,681 | $35.54 | Sale −$59,743 | 25,829 | Yes | Form 4 |
| Burns James WilliamChief Legal Officer | Mar 3, 2025 | Mar 4, 2025 | S | 1,137 | $35.54 | Sale −$40,409 | 18,650 | Yes | Form 4 |
| Burns James WilliamChief Legal Officer | Mar 3, 2025 | Mar 4, 2025 | S | 1,187 | $35.54 | Sale −$42,186 | 21,463 | Yes | Form 4 |
| Burns James WilliamChief Legal Officer | Mar 3, 2025 | Mar 4, 2025 | S | 1,681 | $35.54 | Sale −$59,743 | 25,449 | Yes | Form 4 |
| Washburn Theodore James Jr.Principal Accounting Officer | Mar 1, 2025 | Mar 4, 2025 | M | 777 | $0.00 | $0 | 6,269 | Yes | Form 4 |
| Washburn Theodore James Jr.Principal Accounting Officer | Mar 1, 2025 | Mar 4, 2025 | M | 2,350 | $0.00 | $0 | 8,388 | Yes | Form 4 |
| Washburn Theodore James Jr.Principal Accounting Officer | Mar 1, 2025 | Mar 4, 2025 | M | 2,450 | $0.00 | $0 | 10,141 | Yes | Form 4 |
| Washburn Theodore James Jr.Principal Accounting Officer | Mar 1, 2025 | Mar 4, 2025 | A · derivative | 8,085 | $0.00 | $0 | 8,085 | Yes | Form 4 |
| Washburn Theodore James Jr.Principal Accounting Officer | Mar 1, 2025 | Mar 4, 2025 | A · derivative | 6,142 | $0.00 | $0 | 6,142 | Yes | Form 4 |
| Washburn Theodore James Jr.Principal Accounting Officer | Mar 1, 2025 | Mar 4, 2025 | M · derivative | 777 | $0.00 | $0 | not reported | Yes | Form 4 |
| Washburn Theodore James Jr.Principal Accounting Officer | Mar 1, 2025 | Mar 4, 2025 | M · derivative | 2,350 | $0.00 | $0 | 2,350 | Yes | Form 4 |
| Gheuens SarahChief Medical Officer | Mar 1, 2025 | Mar 4, 2025 | M | 3,833 | $0.00 | $0 | 48,235 | Yes | Form 4 |
| Gheuens SarahChief Medical Officer | Mar 1, 2025 | Mar 4, 2025 | M | 4,000 | $0.00 | $0 | 51,098 | Yes | Form 4 |
| Gheuens SarahChief Medical Officer | Mar 1, 2025 | Mar 4, 2025 | M | 5,667 | $0.00 | $0 | 55,578 | Yes | Form 4 |
| Gheuens SarahChief Medical Officer | Mar 1, 2025 | Mar 4, 2025 | A · derivative | 12,000 | $0.00 | $0 | 12,000 | Yes | Form 4 |
| Gheuens SarahChief Medical Officer | Mar 1, 2025 | Mar 4, 2025 | A · derivative | 43,500 | $35.54 | $1,545,990 | 43,500 | Yes | Form 4 |
| Gheuens SarahChief Medical Officer | Mar 1, 2025 | Mar 4, 2025 | M · derivative | 3,833 | $0.00 | $0 | not reported | Yes | Form 4 |
| Gheuens SarahChief Medical Officer | Mar 1, 2025 | Mar 4, 2025 | M · derivative | 4,000 | $0.00 | $0 | 4,000 | Yes | Form 4 |
| Gheuens SarahChief Medical Officer | Mar 1, 2025 | Mar 4, 2025 | M · derivative | 5,667 | $0.00 | $0 | 11,333 | Yes | Form 4 |
| Goff BrianChief Executive Officer | Mar 1, 2025 | Mar 4, 2025 | M | 8,500 | $0.00 | $0 | 87,292 | Yes | Form 4 |
| Goff BrianChief Executive Officer | Mar 1, 2025 | Mar 4, 2025 | M | 18,000 | $0.00 | $0 | 101,139 | Yes | Form 4 |
| Goff BrianChief Executive Officer | Mar 1, 2025 | Mar 4, 2025 | A · derivative | 39,000 | $0.00 | $0 | 39,000 | Yes | Form 4 |
| Goff BrianChief Executive Officer | Mar 1, 2025 | Mar 4, 2025 | A · derivative | 142,500 | $35.54 | $5,064,450 | 142,500 | Yes | Form 4 |
| Goff BrianChief Executive Officer | Mar 1, 2025 | Mar 4, 2025 | M · derivative | 8,500 | $0.00 | $0 | 8,500 | Yes | Form 4 |
| Goff BrianChief Executive Officer | Mar 1, 2025 | Mar 4, 2025 | M · derivative | 18,000 | $0.00 | $0 | 36,000 | Yes | Form 4 |
| Milanova TsvetaChief Commercial Officer | Mar 1, 2025 | Mar 4, 2025 | M | 5,667 | $0.00 | $0 | 24,573 | Yes | Form 4 |
| Milanova TsvetaChief Commercial Officer | Mar 1, 2025 | Mar 4, 2025 | A · derivative | 12,000 | $0.00 | $0 | 12,000 | Yes | Form 4 |
| Milanova TsvetaChief Commercial Officer | Mar 1, 2025 | Mar 4, 2025 | A · derivative | 43,500 | $35.54 | $1,545,990 | 43,500 | Yes | Form 4 |
| Milanova TsvetaChief Commercial Officer | Mar 1, 2025 | Mar 4, 2025 | M · derivative | 5,667 | $0.00 | $0 | 11,333 | Yes | Form 4 |
| Jones CeciliaChief Financial Officer | Mar 1, 2025 | Mar 4, 2025 | M | 2,000 | $0.00 | $0 | 22,437 | Yes | Form 4 |
| Jones CeciliaChief Financial Officer | Mar 1, 2025 | Mar 4, 2025 | M | 5,667 | $0.00 | $0 | 27,510 | Yes | Form 4 |
| Jones CeciliaChief Financial Officer | Mar 1, 2025 | Mar 4, 2025 | A · derivative | 12,000 | $0.00 | $0 | 12,000 | Yes | Form 4 |
| Jones CeciliaChief Financial Officer | Mar 1, 2025 | Mar 4, 2025 | A · derivative | 15,910 | $0.00 | $0 | 15,910 | Yes | Form 4 |
| Jones CeciliaChief Financial Officer | Mar 1, 2025 | Mar 4, 2025 | A · derivative | 43,500 | $35.54 | $1,545,990 | 43,500 | Yes | Form 4 |
| Jones CeciliaChief Financial Officer | Mar 1, 2025 | Mar 4, 2025 | M · derivative | 2,000 | $0.00 | $0 | 2,000 | Yes | Form 4 |
| Jones CeciliaChief Financial Officer | Mar 1, 2025 | Mar 4, 2025 | M · derivative | 5,667 | $0.00 | $0 | 11,333 | Yes | Form 4 |
| Burns James WilliamChief Legal Officer | Mar 1, 2025 | Mar 4, 2025 | M | 3,833 | $0.00 | $0 | 19,787 | Yes | Form 4 |
| Burns James WilliamChief Legal Officer | Mar 1, 2025 | Mar 4, 2025 | M | 4,000 | $0.00 | $0 | 22,650 | Yes | Form 4 |
| Burns James WilliamChief Legal Officer | Mar 1, 2025 | Mar 4, 2025 | M | 5,667 | $0.00 | $0 | 27,130 | Yes | Form 4 |
| Burns James WilliamChief Legal Officer | Mar 1, 2025 | Mar 4, 2025 | A · derivative | 12,000 | $0.00 | $0 | 12,000 | Yes | Form 4 |
| Burns James WilliamChief Legal Officer | Mar 1, 2025 | Mar 4, 2025 | A · derivative | 11,759 | $0.00 | $0 | 11,759 | Yes | Form 4 |
| Burns James WilliamChief Legal Officer | Mar 1, 2025 | Mar 4, 2025 | A · derivative | 43,500 | $35.54 | $1,545,990 | 43,500 | Yes | Form 4 |
| Burns James WilliamChief Legal Officer | Mar 1, 2025 | Mar 4, 2025 | M · derivative | 3,833 | $0.00 | $0 | not reported | Yes | Form 4 |
| Burns James WilliamChief Legal Officer | Mar 1, 2025 | Mar 4, 2025 | M · derivative | 4,000 | $0.00 | $0 | 4,000 | Yes | Form 4 |
| Burns James WilliamChief Legal Officer | Mar 1, 2025 | Mar 4, 2025 | M · derivative | 5,667 | $0.00 | $0 | 11,333 | Yes | Form 4 |
| Washburn Theodore James Jr.Principal Accounting Officer | Feb 5, 2025 | Feb 5, 2025 | S | 2,272 | $34.39 | Sale −$78,134 | 5,437 | Yes | Form 4 |
| Washburn Theodore James Jr.Principal Accounting Officer | Feb 1, 2025 | Feb 5, 2025 | M | 6,896 | $0.00 | $0 | 7,709 | Yes | Form 4 |
| Washburn Theodore James Jr.Principal Accounting Officer | Feb 1, 2025 | Feb 5, 2025 | M · derivative | 6,896 | $0.00 | $0 | not reported | Yes | Form 4 |
| Milanova TsvetaChief Commercial Officer | Jan 6, 2025 | Jan 7, 2025 | S | 2,804 | $32.18 | Sale −$90,233 | 18,906 | Yes | Form 4 |
| Milanova TsvetaChief Commercial Officer | Jan 3, 2025 | Jan 7, 2025 | M | 8,476 | $0.00 | $0 | 21,710 | Yes | Form 4 |
| Milanova TsvetaChief Commercial Officer | Jan 3, 2025 | Jan 7, 2025 | M · derivative | 8,476 | $0.00 | $0 | 8,475 | Yes | Form 4 |
| Scadden David | Dec 11, 2024 | Dec 13, 2024 | M | 200 | $18.09 | $3,618 | 15,683 | Yes | Form 4 |
| Scadden David | Dec 11, 2024 | Dec 13, 2024 | S | 200 | $46.28 | Sale −$9,256 | 15,483 | Yes | Form 4 |
| Scadden David | Dec 11, 2024 | Dec 13, 2024 | M · derivative | 200 | $18.09 | $3,618 | 29,107 | Yes | Form 4 |
| Washburn Theodore James Jr.Principal Accounting Officer | Nov 8, 2024 | Nov 13, 2024 | S | 772 | $56.09 | Sale −$43,301 | 813 | No | Form 4 |
| Ballal Rahul D. | Nov 8, 2024 | Nov 12, 2024 | M | 10,000 | $25.99 | $259,900 | 17,992 | Yes | Form 4 |
| Ballal Rahul D. | Nov 8, 2024 | Nov 12, 2024 | S | 3,571 | $57.24 | Sale −$204,404 | 14,421 | Yes | Form 4 |
| Ballal Rahul D. | Nov 8, 2024 | Nov 12, 2024 | S | 4,929 | $58.57 | Sale −$288,692 | 9,492 | Yes | Form 4 |
| Ballal Rahul D. | Nov 8, 2024 | Nov 12, 2024 | S | 1,500 | $59.21 | Sale −$88,815 | 7,992 | Yes | Form 4 |
| Ballal Rahul D. | Nov 8, 2024 | Nov 12, 2024 | M · derivative | 10,000 | $25.99 | $259,900 | 17,947 | Yes | Form 4 |
| Burns James WilliamChief Legal Officer | Nov 7, 2024 | Nov 12, 2024 | S | 13,411 | $52.00 | Sale −$697,372 | 24,041 | Yes | Form 4 |
| Burns James WilliamChief Legal Officer | Nov 7, 2024 | Nov 12, 2024 | S | 8,341 | $52.56 | Sale −$438,403 | 15,700 | Yes | Form 4 |
| Ballal Rahul D. | Nov 7, 2024 | Nov 12, 2024 | M | 10,000 | $25.99 | $259,900 | 17,992 | Yes | Form 4 |
| Ballal Rahul D. | Nov 7, 2024 | Nov 12, 2024 | S | 8,132 | $53.32 | Sale −$433,598 | 9,860 | Yes | Form 4 |
| Ballal Rahul D. | Nov 7, 2024 | Nov 12, 2024 | S | 1,868 | $54.41 | Sale −$101,638 | 7,992 | Yes | Form 4 |
| Ballal Rahul D. | Nov 7, 2024 | Nov 12, 2024 | M · derivative | 10,000 | $25.99 | $259,900 | 27,947 | Yes | Form 4 |
| Jones CeciliaChief Financial Officer | Sep 26, 2024 | Sep 30, 2024 | M | 7,473 | $0.00 | $0 | 22,700 | Yes | Form 4 |
| Jones CeciliaChief Financial Officer | Sep 26, 2024 | Sep 30, 2024 | S | 2,542 | $49.03 | Sale −$124,634 | 20,158 | Yes | Form 4 |
| Jones CeciliaChief Financial Officer | Sep 26, 2024 | Sep 30, 2024 | M · derivative | 7,473 | $0.00 | $0 | 7,472 | Yes | Form 4 |
| Smith Cynthia | Aug 11, 2024 | Aug 13, 2024 | M | 2,302 | $0.00 | $0 | 7,992 | No | Form 4 |
| Smith Cynthia | Aug 11, 2024 | Aug 13, 2024 | M · derivative | 2,302 | $0.00 | $0 | 2,302 | No | Form 4 |
| Ballal Rahul D. | Aug 11, 2024 | Aug 13, 2024 | M | 2,302 | $0.00 | $0 | 7,992 | No | Form 4 |
| Ballal Rahul D. | Aug 11, 2024 | Aug 13, 2024 | M · derivative | 2,302 | $0.00 | $0 | 2,302 | No | Form 4 |
| Goff BrianChief Executive Officer | Aug 8, 2024 | Aug 12, 2024 | M | 22,691 | $0.00 | $0 | 89,883 | Yes | Form 4 |
| Goff BrianChief Executive Officer | Aug 8, 2024 | Aug 12, 2024 | S | 11,091 | $42.75 | Sale −$474,140 | 78,792 | Yes | Form 4 |
| Goff BrianChief Executive Officer | Aug 8, 2024 | Aug 12, 2024 | M · derivative | 22,691 | $0.00 | $0 | 22,691 | Yes | Form 4 |
| Gheuens SarahChief Medical Officer | Jul 1, 2024 | Jul 3, 2024 | M | 8,375 | $0.00 | $0 | 47,441 | Yes | Form 4 |
| Gheuens SarahChief Medical Officer | Jul 1, 2024 | Jul 3, 2024 | S | 3,705 | $43.85 | Sale −$162,464 | 43,736 | Yes | Form 4 |
| Gheuens SarahChief Medical Officer | Jul 1, 2024 | Jul 3, 2024 | M · derivative | 8,375 | $0.00 | $0 | 16,749 | Yes | Form 4 |
| Scadden David | Jun 20, 2024 | Jun 24, 2024 | A · derivative | 2,120 | $0.00 | $0 | 2,120 | No | Form 4 |
| Scadden David | Jun 20, 2024 | Jun 24, 2024 | A · derivative | 11,774 | $42.45 | $499,806 | 11,774 | No | Form 4 |
| Schenkein David P | Jun 20, 2024 | Jun 24, 2024 | A · derivative | 2,120 | $0.00 | $0 | 2,120 | No | Form 4 |
| Schenkein David P | Jun 20, 2024 | Jun 24, 2024 | A · derivative | 11,774 | $42.45 | $499,806 | 11,774 | No | Form 4 |
| Owen Catherine E. | Jun 20, 2024 | Jun 24, 2024 | A · derivative | 2,120 | $0.00 | $0 | 2,120 | No | Form 4 |
| Owen Catherine E. | Jun 20, 2024 | Jun 24, 2024 | A · derivative | 11,774 | $42.45 | $499,806 | 11,774 | No | Form 4 |
| Ho Maykin | Jun 20, 2024 | Jun 24, 2024 | A · derivative | 2,120 | $0.00 | $0 | 2,120 | No | Form 4 |
| Ho Maykin | Jun 20, 2024 | Jun 24, 2024 | A · derivative | 11,774 | $42.45 | $499,806 | 11,774 | No | Form 4 |
| Foster-Cheek Kaye I | Jun 20, 2024 | Jun 24, 2024 | A · derivative | 2,120 | $0.00 | $0 | 2,120 | No | Form 4 |
| Foster-Cheek Kaye I | Jun 20, 2024 | Jun 24, 2024 | A · derivative | 11,774 | $42.45 | $499,806 | 11,774 | No | Form 4 |
| Ballal Rahul D. | Jun 20, 2024 | Jun 24, 2024 | A · derivative | 2,120 | $0.00 | $0 | 2,120 | No | Form 4 |
| Ballal Rahul D. | Jun 20, 2024 | Jun 24, 2024 | A · derivative | 11,774 | $42.45 | $499,806 | 11,774 | No | Form 4 |
| Capello Jeffrey D | Jun 20, 2024 | Jun 24, 2024 | A · derivative | 2,120 | $0.00 | $0 | 2,120 | No | Form 4 |
| Capello Jeffrey D | Jun 20, 2024 | Jun 24, 2024 | A · derivative | 11,774 | $42.45 | $499,806 | 11,774 | No | Form 4 |
| Smith Cynthia | Jun 20, 2024 | Jun 24, 2024 | A · derivative | 2,120 | $0.00 | $0 | 2,120 | No | Form 4 |
| Smith Cynthia | Jun 20, 2024 | Jun 24, 2024 | A · derivative | 11,774 | $42.45 | $499,806 | 11,774 | No | Form 4 |
| Fouse Jacqualyn A | Jun 20, 2024 | Jun 24, 2024 | A · derivative | 2,120 | $0.00 | $0 | 2,120 | No | Form 4 |
| Fouse Jacqualyn A | Jun 20, 2024 | Jun 24, 2024 | A · derivative | 11,774 | $42.45 | $499,806 | 11,774 | No | Form 4 |
| Capello Jeffrey D | Jun 13, 2024 | Jun 17, 2024 | M | 1,976 | $0.00 | $0 | 1,976 | No | Form 4 |
| Capello Jeffrey D | Jun 13, 2024 | Jun 17, 2024 | M · derivative | 1,976 | $0.00 | $0 | 3,953 | No | Form 4 |
| Owen Catherine E. | Jun 13, 2024 | Jun 17, 2024 | M | 1,976 | $0.00 | $0 | 1,976 | No | Form 4 |
| Owen Catherine E. | Jun 13, 2024 | Jun 17, 2024 | M · derivative | 1,976 | $0.00 | $0 | 3,953 | No | Form 4 |
| Scadden David | Jun 13, 2024 | Jun 17, 2024 | M | 3,388 | $0.00 | $0 | 15,483 | No | Form 4 |
| Scadden David | Jun 13, 2024 | Jun 17, 2024 | M · derivative | 3,388 | $0.00 | $0 | not reported | No | Form 4 |
| Ho Maykin | Jun 13, 2024 | Jun 17, 2024 | M | 3,388 | $0.00 | $0 | 14,912 | No | Form 4 |
| Ho Maykin | Jun 13, 2024 | Jun 17, 2024 | M · derivative | 3,388 | $0.00 | $0 | not reported | No | Form 4 |
| Smith Cynthia | Jun 13, 2024 | Jun 17, 2024 | M | 3,388 | $0.00 | $0 | 5,690 | No | Form 4 |
| Smith Cynthia | Jun 13, 2024 | Jun 17, 2024 | M · derivative | 3,388 | $0.00 | $0 | not reported | No | Form 4 |
| Ballal Rahul D. | Jun 13, 2024 | Jun 17, 2024 | M | 3,388 | $0.00 | $0 | 5,690 | No | Form 4 |
| Ballal Rahul D. | Jun 13, 2024 | Jun 17, 2024 | M · derivative | 3,388 | $0.00 | $0 | not reported | No | Form 4 |
| Schenkein David P | Jun 13, 2024 | Jun 17, 2024 | M | 3,388 | $0.00 | $0 | 126,242 | No | Form 4 |
| Schenkein David P | Jun 13, 2024 | Jun 17, 2024 | M · derivative | 3,388 | $0.00 | $0 | not reported | No | Form 4 |
| Fouse Jacqualyn A | Jun 13, 2024 | Jun 17, 2024 | M | 3,388 | $0.00 | $0 | 140,784 | No | Form 4 |
| Fouse Jacqualyn A | Jun 13, 2024 | Jun 17, 2024 | M · derivative | 3,388 | $0.00 | $0 | not reported | No | Form 4 |
| Foster-Cheek Kaye I | Jun 13, 2024 | Jun 17, 2024 | M | 3,388 | $0.00 | $0 | 8,912 | No | Form 4 |
| Foster-Cheek Kaye I | Jun 13, 2024 | Jun 17, 2024 | G | 3,564 | $0.00 | $0 | 5,348 | No | Form 4 |
| Foster-Cheek Kaye I | Jun 13, 2024 | Jun 17, 2024 | M · derivative | 3,388 | $0.00 | $0 | not reported | No | Form 4 |
| Goff BrianChief Executive Officer | Jun 5, 2024 | Jun 7, 2024 | M | 25,527 | $0.00 | $0 | 79,307 | Yes | Form 4 |
| Goff BrianChief Executive Officer | Jun 5, 2024 | Jun 7, 2024 | S | 12,115 | $48.84 | Sale −$591,697 | 67,192 | Yes | Form 4 |
| Goff BrianChief Executive Officer | Jun 5, 2024 | Jun 7, 2024 | M · derivative | 25,527 | $0.00 | $0 | 76,583 | Yes | Form 4 |
| Washburn Theodore James Jr.Principal Accounting Officer | Jun 3, 2024 | Jun 5, 2024 | S | 1,362 | $44.39 | Sale −$60,459 | 1,524 | No | Form 4 |
| Fouse Jacqualyn A | Apr 10, 2024 | Apr 10, 2024 | S | 7,791 | $27.55 | Sale −$214,642 | 137,396 | Yes | Form 4 |
| Fouse Jacqualyn A | Apr 8, 2024 | Apr 10, 2024 | M | 15,934 | $0.00 | $0 | 145,187 | Yes | Form 4 |
| Fouse Jacqualyn A | Apr 8, 2024 | Apr 10, 2024 | M · derivative | 15,934 | $0.00 | $0 | 15,933 | Yes | Form 4 |
| Foster-Cheek Kaye I | Mar 7, 2024 | Mar 11, 2024 | S | 1,285 | $31.62 | Sale −$40,632 | 5,524 | No | Form 4 |
| Foster-Cheek Kaye I | Mar 6, 2024 | Mar 7, 2024 | S | 4,415 | $31.99 | Sale −$141,236 | 6,809 | No | Form 4 |
| Washburn Theodore James Jr.Principal Accounting Officer | Mar 5, 2024 | Mar 7, 2024 | S | 1,913 | $31.75 | Sale −$60,738 | 2,886 | No | Form 4 |
| Foster-Cheek Kaye I | Mar 5, 2024 | Mar 7, 2024 | S | 300 | $32.21 | Sale −$9,663 | 11,224 | No | Form 4 |
| Burns James WilliamChief Legal Officer | Mar 5, 2024 | Mar 5, 2024 | S | 1,293 | $32.57 | Sale −$42,113 | 34,518 | Yes | Form 4 |
| Burns James WilliamChief Legal Officer | Mar 5, 2024 | Mar 5, 2024 | S | 1,349 | $32.57 | Sale −$43,937 | 37,169 | Yes | Form 4 |
| Goff BrianChief Executive Officer | Mar 5, 2024 | Mar 5, 2024 | S | 4,156 | $32.57 | Sale −$135,361 | 53,780 | Yes | Form 4 |
| Washburn Theodore James Jr.Principal Accounting Officer | Mar 5, 2024 | Mar 5, 2024 | S | 295 | $32.57 | Sale −$9,608 | 3,368 | Yes | Form 4 |
| Washburn Theodore James Jr.Principal Accounting Officer | Mar 5, 2024 | Mar 5, 2024 | S | 919 | $32.57 | Sale −$29,932 | 4,799 | Yes | Form 4 |
| Jones CeciliaChief Financial Officer | Mar 5, 2024 | Mar 5, 2024 | S | 672 | $32.57 | Sale −$21,887 | 14,840 | Yes | Form 4 |
| Gheuens SarahChief Medical Officer | Mar 5, 2024 | Mar 5, 2024 | S | 1,293 | $32.57 | Sale −$42,113 | 36,415 | Yes | Form 4 |
| Gheuens SarahChief Medical Officer | Mar 5, 2024 | Mar 5, 2024 | S | 1,349 | $32.57 | Sale −$43,937 | 39,066 | Yes | Form 4 |
| Milanova TsvetaChief Commercial Officer | Mar 1, 2024 | Mar 5, 2024 | A · derivative | 17,000 | $0.00 | $0 | 17,000 | No | Form 4 |
| Milanova TsvetaChief Commercial Officer | Mar 1, 2024 | Mar 5, 2024 | A · derivative | 60,000 | $32.27 | $1,936,200 | 60,000 | No | Form 4 |
| Burns James WilliamChief Legal Officer | Mar 1, 2024 | Mar 5, 2024 | M | 3,834 | $0.00 | $0 | 35,811 | Yes | Form 4 |
| Burns James WilliamChief Legal Officer | Mar 1, 2024 | Mar 5, 2024 | M | 4,000 | $0.00 | $0 | 38,518 | Yes | Form 4 |
| Burns James WilliamChief Legal Officer | Mar 1, 2024 | Mar 5, 2024 | A · derivative | 17,000 | $0.00 | $0 | 17,000 | Yes | Form 4 |
| Burns James WilliamChief Legal Officer | Mar 1, 2024 | Mar 5, 2024 | A · derivative | 60,000 | $32.27 | $1,936,200 | 60,000 | Yes | Form 4 |
| Burns James WilliamChief Legal Officer | Mar 1, 2024 | Mar 5, 2024 | M · derivative | 3,834 | $0.00 | $0 | 3,833 | Yes | Form 4 |
| Burns James WilliamChief Legal Officer | Mar 1, 2024 | Mar 5, 2024 | M · derivative | 4,000 | $0.00 | $0 | 8,000 | Yes | Form 4 |
| Goff BrianChief Executive Officer | Mar 1, 2024 | Mar 5, 2024 | M | 8,500 | $0.00 | $0 | 57,936 | Yes | Form 4 |
| Goff BrianChief Executive Officer | Mar 1, 2024 | Mar 5, 2024 | A · derivative | 54,000 | $0.00 | $0 | 54,000 | Yes | Form 4 |
| Goff BrianChief Executive Officer | Mar 1, 2024 | Mar 5, 2024 | A · derivative | 195,500 | $32.27 | $6,308,785 | 195,500 | Yes | Form 4 |
| Goff BrianChief Executive Officer | Mar 1, 2024 | Mar 5, 2024 | M · derivative | 8,500 | $0.00 | $0 | 17,000 | Yes | Form 4 |
| Washburn Theodore James Jr.Principal Accounting Officer | Mar 1, 2024 | Mar 5, 2024 | M | 777 | $0.00 | $0 | 3,663 | Yes | Form 4 |
| Washburn Theodore James Jr.Principal Accounting Officer | Mar 1, 2024 | Mar 5, 2024 | M | 2,350 | $0.00 | $0 | 5,718 | Yes | Form 4 |
| Washburn Theodore James Jr.Principal Accounting Officer | Mar 1, 2024 | Mar 5, 2024 | A · derivative | 7,350 | $0.00 | $0 | 7,350 | Yes | Form 4 |
| Washburn Theodore James Jr.Principal Accounting Officer | Mar 1, 2024 | Mar 5, 2024 | M · derivative | 777 | $0.00 | $0 | 777 | Yes | Form 4 |
| Washburn Theodore James Jr.Principal Accounting Officer | Mar 1, 2024 | Mar 5, 2024 | M · derivative | 2,350 | $0.00 | $0 | 4,700 | Yes | Form 4 |
| Jones CeciliaChief Financial Officer | Mar 1, 2024 | Mar 5, 2024 | M | 2,000 | $0.00 | $0 | 15,512 | Yes | Form 4 |
| Jones CeciliaChief Financial Officer | Mar 1, 2024 | Mar 5, 2024 | A · derivative | 17,000 | $0.00 | $0 | 17,000 | Yes | Form 4 |
| Jones CeciliaChief Financial Officer | Mar 1, 2024 | Mar 5, 2024 | A · derivative | 60,000 | $32.27 | $1,936,200 | 60,000 | Yes | Form 4 |
| Jones CeciliaChief Financial Officer | Mar 1, 2024 | Mar 5, 2024 | M · derivative | 2,000 | $0.00 | $0 | 4,000 | Yes | Form 4 |
| Gheuens SarahChief Medical Officer | Mar 1, 2024 | Mar 5, 2024 | M | 3,834 | $0.00 | $0 | 37,708 | Yes | Form 4 |
| Gheuens SarahChief Medical Officer | Mar 1, 2024 | Mar 5, 2024 | M | 4,000 | $0.00 | $0 | 40,415 | Yes | Form 4 |
| Gheuens SarahChief Medical Officer | Mar 1, 2024 | Mar 5, 2024 | A · derivative | 17,000 | $0.00 | $0 | 17,000 | Yes | Form 4 |
| Gheuens SarahChief Medical Officer | Mar 1, 2024 | Mar 5, 2024 | A · derivative | 60,000 | $32.27 | $1,936,200 | 60,000 | Yes | Form 4 |
| Gheuens SarahChief Medical Officer | Mar 1, 2024 | Mar 5, 2024 | M · derivative | 3,834 | $0.00 | $0 | 3,833 | Yes | Form 4 |
| Gheuens SarahChief Medical Officer | Mar 1, 2024 | Mar 5, 2024 | M · derivative | 4,000 | $0.00 | $0 | 8,000 | Yes | Form 4 |
| Schenkein David P | Feb 27, 2024 | Feb 29, 2024 | M | 11,858 | $31.64 | $375,187 | 134,712 | No | Form 4 |
| Schenkein David P | Feb 27, 2024 | Feb 29, 2024 | S | 11,858 | $33.60 | Sale −$398,429 | 122,854 | No | Form 4 |
| Schenkein David P | Feb 27, 2024 | Feb 29, 2024 | M | 57,471 | $31.64 | $1,818,382 | 180,325 | No | Form 4 |
| Schenkein David P | Feb 27, 2024 | Feb 29, 2024 | S | 57,471 | $34.89 | Sale −$2,005,163 | 122,854 | No | Form 4 |
| Schenkein David P | Feb 27, 2024 | Feb 29, 2024 | M · derivative | 11,858 | $31.64 | $375,187 | 57,471 | No | Form 4 |
| Schenkein David P | Feb 27, 2024 | Feb 29, 2024 | M · derivative | 57,471 | $31.64 | $1,818,382 | not reported | No | Form 4 |
| Schenkein David P | Feb 26, 2024 | Feb 27, 2024 | M | 20,411 | $31.64 | $645,804 | 143,265 | No | Form 4 |
| Schenkein David P | Feb 26, 2024 | Feb 27, 2024 | S | 20,411 | $33.19 | Sale −$677,441 | 122,854 | No | Form 4 |
| Schenkein David P | Feb 26, 2024 | Feb 27, 2024 | M · derivative | 20,411 | $31.64 | $645,804 | 69,329 | No | Form 4 |
| Schenkein David P | Feb 23, 2024 | Feb 27, 2024 | M | 47,731 | $31.64 | $1,510,209 | 170,585 | No | Form 4 |
| Schenkein David P | Feb 23, 2024 | Feb 27, 2024 | S | 47,731 | $33.05 | Sale −$1,577,510 | 122,854 | No | Form 4 |
| Schenkein David P | Feb 23, 2024 | Feb 27, 2024 | M · derivative | 47,731 | $31.64 | $1,510,209 | 89,740 | No | Form 4 |
| Washburn Theodore James Jr.Principal Accounting Officer | Feb 20, 2024 | Feb 22, 2024 | S | 504 | $26.63 | Sale −$13,422 | 2,741 | No | Form 4 |
| Washburn Theodore James Jr.Principal Accounting Officer | Feb 14, 2024 | Feb 14, 2024 | S | 273 | $25.14 | Sale −$6,863 | 3,245 | Yes | Form 4 |
| Burns James WilliamChief Legal Officer | Feb 14, 2024 | Feb 14, 2024 | S | 545 | $25.14 | Sale −$13,701 | 31,666 | Yes | Form 4 |
| Gheuens SarahChief Medical Officer | Feb 14, 2024 | Feb 14, 2024 | S | 642 | $25.14 | Sale −$16,140 | 33,431 | Yes | Form 4 |
| Washburn Theodore James Jr.Principal Accounting Officer | Feb 12, 2024 | Feb 14, 2024 | M | 777 | $0.00 | $0 | 3,518 | Yes | Form 4 |
| Washburn Theodore James Jr.Principal Accounting Officer | Feb 12, 2024 | Feb 14, 2024 | M · derivative | 777 | $0.00 | $0 | not reported | Yes | Form 4 |
| Burns James WilliamChief Legal Officer | Feb 12, 2024 | Feb 14, 2024 | M | 1,833 | $0.00 | $0 | 32,211 | Yes | Form 4 |
| Burns James WilliamChief Legal Officer | Feb 12, 2024 | Feb 14, 2024 | M · derivative | 1,833 | $0.00 | $0 | not reported | Yes | Form 4 |
| Gheuens SarahChief Medical Officer | Feb 12, 2024 | Feb 14, 2024 | M | 2,162 | $0.00 | $0 | 34,073 | Yes | Form 4 |
| Gheuens SarahChief Medical Officer | Feb 12, 2024 | Feb 14, 2024 | M · derivative | 2,162 | $0.00 | $0 | not reported | Yes | Form 4 |
| Milanova TsvetaChief Commercial Officer | Jan 24, 2024 | Jan 24, 2024 | S | 1,618 | $21.64 | Sale −$35,014 | 13,234 | Yes | Form 4 |
| Goff BrianChief Executive Officer | Jan 24, 2024 | Jan 24, 2024 | S | 7,635 | $21.64 | Sale −$165,221 | 49,436 | Yes | Form 4 |
| Fouse Jacqualyn A | Jan 24, 2024 | Jan 24, 2024 | S | 10,722 | $21.64 | Sale −$232,024 | 129,253 | Yes | Form 4 |
| Jones CeciliaChief Financial Officer | Jan 24, 2024 | Jan 24, 2024 | S | 1,886 | $21.64 | Sale −$40,813 | 13,069 | Yes | Form 4 |
| Gheuens SarahChief Medical Officer | Jan 24, 2024 | Jan 24, 2024 | S | 1,708 | $21.64 | Sale −$36,961 | 31,911 | Yes | Form 4 |
| Burns James WilliamChief Legal Officer | Jan 24, 2024 | Jan 24, 2024 | S | 1,708 | $21.64 | Sale −$36,961 | 30,378 | Yes | Form 4 |
| Milanova TsvetaChief Commercial Officer | Jan 20, 2024 | Jan 24, 2024 | M | 5,448 | $0.00 | $0 | 14,852 | Yes | Form 4 |
| Milanova TsvetaChief Commercial Officer | Jan 20, 2024 | Jan 24, 2024 | M · derivative | 5,448 | $0.00 | $0 | not reported | Yes | Form 4 |
| Goff BrianChief Executive Officer | Jan 20, 2024 | Jan 24, 2024 | M | 17,018 | $0.00 | $0 | 57,071 | Yes | Form 4 |
| Goff BrianChief Executive Officer | Jan 20, 2024 | Jan 24, 2024 | M · derivative | 17,018 | $0.00 | $0 | 102,110 | Yes | Form 4 |
| Fouse Jacqualyn A | Jan 20, 2024 | Jan 24, 2024 | M | 23,900 | $0.00 | $0 | 139,975 | Yes | Form 4 |
| Fouse Jacqualyn A | Jan 20, 2024 | Jan 24, 2024 | M · derivative | 23,900 | $0.00 | $0 | not reported | Yes | Form 4 |
| Jones CeciliaChief Financial Officer | Jan 20, 2024 | Jan 24, 2024 | M | 5,380 | $0.00 | $0 | 14,955 | Yes | Form 4 |
| Jones CeciliaChief Financial Officer | Jan 20, 2024 | Jan 24, 2024 | M · derivative | 5,380 | $0.00 | $0 | not reported | Yes | Form 4 |
| Gheuens SarahChief Medical Officer | Jan 20, 2024 | Jan 24, 2024 | M | 5,750 | $0.00 | $0 | 33,619 | Yes | Form 4 |
| Gheuens SarahChief Medical Officer | Jan 20, 2024 | Jan 24, 2024 | M · derivative | 5,750 | $0.00 | $0 | not reported | Yes | Form 4 |
| Burns James WilliamChief Legal Officer | Jan 20, 2024 | Jan 24, 2024 | M | 5,750 | $0.00 | $0 | 32,086 | Yes | Form 4 |
| Burns James WilliamChief Legal Officer | Jan 20, 2024 | Jan 24, 2024 | M · derivative | 5,750 | $0.00 | $0 | not reported | Yes | Form 4 |
| Gheuens SarahChief Medical Officer | Jan 9, 2024 | Jan 9, 2024 | S | 1,789 | $22.99 | Sale −$41,129 | 27,869 | Yes | Form 4 |
| Burns James WilliamChief Legal Officer | Jan 9, 2024 | Jan 9, 2024 | S | 1,163 | $22.99 | Sale −$26,737 | 26,336 | Yes | Form 4 |
| Fouse Jacqualyn A | Jan 9, 2024 | Jan 9, 2024 | S | 8,391 | $22.99 | Sale −$192,909 | 116,075 | Yes | Form 4 |
| Goff BrianChief Executive Officer | Jan 9, 2024 | Jan 9, 2024 | S | 12,066 | $22.99 | Sale −$277,397 | 40,053 | Yes | Form 4 |
| Gheuens SarahChief Medical Officer | Jan 5, 2024 | Jan 9, 2024 | M | 5,000 | $0.00 | $0 | 29,658 | Yes | Form 4 |