ALNYALNYLAM PHARMACEUTICALS, INC.
- Market cap
- $29.98B
- as of 2026-10-23
- Latest close
- $224.03
- as of 2026-10-23
- Sector
- Healthcare
- as of 2026-10-24
- Industry
- Biotechnology
- as of 2026-10-24
Cluster
No cluster in the last 90 days under the default rule (14d · ≥2 insiders · all roles).
Form 4 historysince 2023-12-29
Showing the latest 500 of 1009 transactions.
| Insider | Traded | Filed | Type | Shares | Price | Value | Owned after | 10b5-1 plan | Filing |
|---|---|---|---|---|---|---|---|---|---|
| Supran BryanEVP, CLO and Secretary | Oct 2 | Oct 6 | S | 1,758 | $226.88 | Sale −$398,855 | 12,807 | No | Form 4 |
| Greenstreet YvonneChief Executive Officer | Sep 19 | Sep 22 | A | 107 | $0.00 | $0 | 95,802 | No | Form 4 |
| Cravatt Benjamin | Jun 1 | Jun 3 | A · derivative | 4,393 | $295.63 | $1,298,703 | 4,393 | No | Form 4 |
| Pyott David E I | Jun 1 | Jun 3 | M | 3,830 | $0.00 | $0 | 5,412 | Yes | Form 4 |
| Pyott David E I | Jun 1 | Jun 3 | S | 921 | $297.71 | Sale −$274,191 | 4,491 | Yes | Form 4 |
| Pyott David E I | Jun 1 | Jun 3 | S | 1,175 | $298.91 | Sale −$351,219 | 3,316 | Yes | Form 4 |
| Pyott David E I | Jun 1 | Jun 3 | S | 1,222 | $299.87 | Sale −$366,441 | 2,094 | Yes | Form 4 |
| Pyott David E I | Jun 1 | Jun 3 | S | 495 | $300.72 | Sale −$148,856 | 1,599 | Yes | Form 4 |
| Pyott David E I | Jun 1 | Jun 3 | S | 17 | $302.65 | Sale −$5,145 | 1,582 | Yes | Form 4 |
| Pyott David E I | Jun 1 | Jun 3 | M · derivative | 3,830 | $70.20 | $268,866 | not reported | Yes | Form 4 |
| Arbuckle Stuart A | May 20 | May 22 | A | 671 | $0.00 | $0 | 671 | No | Form 4 |
| Arbuckle Stuart A | May 20 | May 22 | A · derivative | 1,441 | $298.48 | $430,110 | 1,441 | No | Form 4 |
| Ausiello Dennis A | May 20 | May 22 | A | 671 | $0.00 | $0 | 1,582 | No | Form 4 |
| Ausiello Dennis A | May 20 | May 22 | A · derivative | 1,441 | $298.48 | $430,110 | 1,441 | No | Form 4 |
| Brandicourt Olivier | May 20 | May 22 | A | 671 | $0.00 | $0 | 1,446 | No | Form 4 |
| Brandicourt Olivier | May 20 | May 22 | A · derivative | 1,441 | $298.48 | $430,110 | 1,441 | No | Form 4 |
| Hamburg Margaret A | May 20 | May 22 | A | 671 | $0.00 | $0 | 1,582 | No | Form 4 |
| Hamburg Margaret A | May 20 | May 22 | A · derivative | 1,441 | $298.48 | $430,110 | 1,441 | No | Form 4 |
| Kellogg Peter N | May 20 | May 22 | A | 671 | $0.00 | $0 | 1,446 | No | Form 4 |
| Kellogg Peter N | May 20 | May 22 | A · derivative | 1,441 | $298.48 | $430,110 | 1,441 | No | Form 4 |
| Pyott David E I | May 20 | May 22 | A | 671 | $0.00 | $0 | 1,582 | No | Form 4 |
| Pyott David E I | May 20 | May 22 | A · derivative | 1,441 | $298.48 | $430,110 | 1,441 | No | Form 4 |
| Reitan Colleen F | May 20 | May 22 | A | 671 | $0.00 | $0 | 1,446 | No | Form 4 |
| Reitan Colleen F | May 20 | May 22 | A · derivative | 1,441 | $298.48 | $430,110 | 1,441 | No | Form 4 |
| Schulman Amy W | May 20 | May 22 | A | 838 | $0.00 | $0 | 24,049 | No | Form 4 |
| Schulman Amy W | May 20 | May 22 | A · derivative | 1,802 | $298.48 | $537,861 | 1,802 | No | Form 4 |
| Sigal Charles Elliott | May 20 | May 22 | A | 671 | $0.00 | $0 | 1,446 | No | Form 4 |
| Sigal Charles Elliott | May 20 | May 22 | A · derivative | 1,441 | $298.48 | $430,110 | 1,441 | No | Form 4 |
| Schulman Amy W | May 13 | May 14 | M | 11,250 | $70.20 | $789,750 | 23,211 | No | Form 4 |
| Schulman Amy W | May 13 | May 14 | M · derivative | 11,250 | $70.20 | $789,750 | not reported | No | Form 4 |
| McLaughlin MelissaChief Human Resources Officer | Apr 6 | Apr 7 | S | 56 | $320.14 | Sale −$17,928 | 11,673 | Yes | Form 4 |
| McLaughlin MelissaChief Human Resources Officer | Apr 6 | Apr 7 | S | 909 | $329.76 | Sale −$299,752 | 10,764 | Yes | Form 4 |
| McLaughlin MelissaChief Human Resources Officer | Apr 6 | Apr 7 | S | 829 | $330.46 | Sale −$273,951 | 9,935 | Yes | Form 4 |
| McLaughlin MelissaChief Human Resources Officer | Apr 6 | Apr 7 | S | 293 | $331.89 | Sale −$97,244 | 9,642 | Yes | Form 4 |
| McLaughlin MelissaChief Human Resources Officer | Apr 6 | Apr 7 | S | 199 | $333.94 | Sale −$66,454 | 9,443 | Yes | Form 4 |
| McLaughlin MelissaChief Human Resources Officer | Apr 2 | Apr 7 | S | 265 | $316.61 | Sale −$83,902 | 13,088 | Yes | Form 4 |
| McLaughlin MelissaChief Human Resources Officer | Apr 2 | Apr 7 | S | 359 | $317.44 | Sale −$113,961 | 12,729 | Yes | Form 4 |
| McLaughlin MelissaChief Human Resources Officer | Apr 2 | Apr 7 | S | 209 | $318.47 | Sale −$66,560 | 12,520 | Yes | Form 4 |
| McLaughlin MelissaChief Human Resources Officer | Apr 2 | Apr 7 | S | 86 | $319.69 | Sale −$27,493 | 12,434 | Yes | Form 4 |
| McLaughlin MelissaChief Human Resources Officer | Apr 2 | Apr 7 | S | 147 | $320.62 | Sale −$47,131 | 12,287 | Yes | Form 4 |
| McLaughlin MelissaChief Human Resources Officer | Apr 2 | Apr 7 | S | 224 | $321.64 | Sale −$72,047 | 12,063 | Yes | Form 4 |
| McLaughlin MelissaChief Human Resources Officer | Apr 2 | Apr 7 | S | 245 | $322.86 | Sale −$79,101 | 11,818 | Yes | Form 4 |
| McLaughlin MelissaChief Human Resources Officer | Apr 2 | Apr 7 | S | 81 | $323.64 | Sale −$26,215 | 11,737 | Yes | Form 4 |
| McLaughlin MelissaChief Human Resources Officer | Apr 2 | Apr 7 | S | 8 | $325.49 | Sale −$2,604 | 11,729 | Yes | Form 4 |
| Fitzgerald Kevin JosephCSO & EVP, Head of Research | Mar 5 | Mar 6 | S | 124 | $321.81 | Sale −$39,904 | 21,103 | Yes | Form 4 |
| Fitzgerald Kevin JosephCSO & EVP, Head of Research | Mar 5 | Mar 6 | S | 233 | $323.25 | Sale −$75,317 | 20,870 | Yes | Form 4 |
| Fitzgerald Kevin JosephCSO & EVP, Head of Research | Mar 5 | Mar 6 | S | 148 | $324.60 | Sale −$48,041 | 20,722 | Yes | Form 4 |
| Fitzgerald Kevin JosephCSO & EVP, Head of Research | Mar 5 | Mar 6 | S | 153 | $326.24 | Sale −$49,915 | 20,569 | Yes | Form 4 |
| Garg PushkalEVP Chief R&D | Mar 5 | Mar 6 | S | 654 | $322.33 | Sale −$210,804 | 20,443 | Yes | Form 4 |
| Garg PushkalEVP Chief R&D | Mar 5 | Mar 6 | S | 740 | $323.55 | Sale −$239,427 | 19,703 | Yes | Form 4 |
| Garg PushkalEVP Chief R&D | Mar 5 | Mar 6 | S | 510 | $324.59 | Sale −$165,541 | 19,193 | Yes | Form 4 |
| Garg PushkalEVP Chief R&D | Mar 5 | Mar 6 | S | 500 | $326.08 | Sale −$163,040 | 18,693 | Yes | Form 4 |
| Fitzgerald Kevin JosephCSO & EVP, Head of Research | Mar 4 | Mar 6 | S | 29 | $319.03 | Sale −$9,252 | 21,831 | Yes | Form 4 |
| Fitzgerald Kevin JosephCSO & EVP, Head of Research | Mar 4 | Mar 6 | S | 28 | $320.01 | Sale −$8,960 | 21,803 | Yes | Form 4 |
| Fitzgerald Kevin JosephCSO & EVP, Head of Research | Mar 4 | Mar 6 | S | 59 | $320.81 | Sale −$18,928 | 21,744 | Yes | Form 4 |
| Fitzgerald Kevin JosephCSO & EVP, Head of Research | Mar 4 | Mar 6 | S | 79 | $321.82 | Sale −$25,424 | 21,665 | Yes | Form 4 |
| Fitzgerald Kevin JosephCSO & EVP, Head of Research | Mar 4 | Mar 6 | S | 96 | $323.01 | Sale −$31,009 | 21,569 | Yes | Form 4 |
| Fitzgerald Kevin JosephCSO & EVP, Head of Research | Mar 4 | Mar 6 | S | 210 | $323.84 | Sale −$68,006 | 21,359 | Yes | Form 4 |
| Fitzgerald Kevin JosephCSO & EVP, Head of Research | Mar 4 | Mar 6 | S | 75 | $324.88 | Sale −$24,366 | 21,284 | Yes | Form 4 |
| Fitzgerald Kevin JosephCSO & EVP, Head of Research | Mar 4 | Mar 6 | S | 57 | $325.67 | Sale −$18,563 | 21,227 | Yes | Form 4 |
| Tanguler TolgaEVP, Chief Commercial Officer | Mar 4 | Mar 6 | S | 106 | $319.03 | Sale −$33,817 | 36,500 | No | Form 4 |
| Tanguler TolgaEVP, Chief Commercial Officer | Mar 4 | Mar 6 | S | 102 | $320.01 | Sale −$32,641 | 36,398 | No | Form 4 |
| Tanguler TolgaEVP, Chief Commercial Officer | Mar 4 | Mar 6 | S | 215 | $320.81 | Sale −$68,974 | 36,183 | No | Form 4 |
| Tanguler TolgaEVP, Chief Commercial Officer | Mar 4 | Mar 6 | S | 289 | $321.82 | Sale −$93,006 | 35,894 | No | Form 4 |
| Tanguler TolgaEVP, Chief Commercial Officer | Mar 4 | Mar 6 | S | 350 | $323.01 | Sale −$113,054 | 35,544 | No | Form 4 |
| Tanguler TolgaEVP, Chief Commercial Officer | Mar 4 | Mar 6 | S | 767 | $323.84 | Sale −$248,385 | 34,777 | No | Form 4 |
| Tanguler TolgaEVP, Chief Commercial Officer | Mar 4 | Mar 6 | S | 272 | $324.88 | Sale −$88,367 | 34,505 | No | Form 4 |
| Tanguler TolgaEVP, Chief Commercial Officer | Mar 4 | Mar 6 | S | 208 | $325.67 | Sale −$67,739 | 34,297 | No | Form 4 |
| Poulton Jeffrey V.EVP, Chief Financial Officer | Mar 4 | Mar 6 | S | 114 | $319.03 | Sale −$36,369 | 64,159 | No | Form 4 |
| Poulton Jeffrey V.EVP, Chief Financial Officer | Mar 4 | Mar 6 | S | 109 | $320.01 | Sale −$34,881 | 64,050 | No | Form 4 |
| Poulton Jeffrey V.EVP, Chief Financial Officer | Mar 4 | Mar 6 | S | 230 | $320.81 | Sale −$73,786 | 63,820 | No | Form 4 |
| Poulton Jeffrey V.EVP, Chief Financial Officer | Mar 4 | Mar 6 | S | 309 | $321.82 | Sale −$99,442 | 63,511 | No | Form 4 |
| Poulton Jeffrey V.EVP, Chief Financial Officer | Mar 4 | Mar 6 | S | 374 | $323.01 | Sale −$120,806 | 63,137 | No | Form 4 |
| Poulton Jeffrey V.EVP, Chief Financial Officer | Mar 4 | Mar 6 | S | 818 | $323.84 | Sale −$264,901 | 62,319 | No | Form 4 |
| Poulton Jeffrey V.EVP, Chief Financial Officer | Mar 4 | Mar 6 | S | 291 | $324.88 | Sale −$94,540 | 62,028 | No | Form 4 |
| Poulton Jeffrey V.EVP, Chief Financial Officer | Mar 4 | Mar 6 | S | 223 | $325.67 | Sale −$72,624 | 61,805 | No | Form 4 |
| Greenstreet YvonneChief Executive Officer | Mar 4 | Mar 6 | S | 135 | $319.03 | Sale −$43,069 | 98,493 | No | Form 4 |
| Greenstreet YvonneChief Executive Officer | Mar 4 | Mar 6 | S | 129 | $320.01 | Sale −$41,281 | 98,364 | No | Form 4 |
| Greenstreet YvonneChief Executive Officer | Mar 4 | Mar 6 | S | 274 | $320.81 | Sale −$87,902 | 98,090 | No | Form 4 |
| Greenstreet YvonneChief Executive Officer | Mar 4 | Mar 6 | S | 368 | $321.82 | Sale −$118,430 | 97,722 | No | Form 4 |
| Greenstreet YvonneChief Executive Officer | Mar 4 | Mar 6 | S | 444 | $323.01 | Sale −$143,416 | 97,278 | No | Form 4 |
| Greenstreet YvonneChief Executive Officer | Mar 4 | Mar 6 | S | 973 | $323.84 | Sale −$315,096 | 96,305 | No | Form 4 |
| Greenstreet YvonneChief Executive Officer | Mar 4 | Mar 6 | S | 345 | $324.88 | Sale −$112,084 | 95,960 | No | Form 4 |
| Greenstreet YvonneChief Executive Officer | Mar 4 | Mar 6 | S | 265 | $325.67 | Sale −$86,303 | 95,695 | No | Form 4 |
| Garg PushkalEVP Chief R&D | Mar 4 | Mar 6 | S | 106 | $319.03 | Sale −$33,817 | 23,300 | Yes | Form 4 |
| Garg PushkalEVP Chief R&D | Mar 4 | Mar 6 | S | 102 | $320.01 | Sale −$32,641 | 23,198 | Yes | Form 4 |
| Garg PushkalEVP Chief R&D | Mar 4 | Mar 6 | S | 215 | $320.81 | Sale −$68,974 | 22,983 | Yes | Form 4 |
| Garg PushkalEVP Chief R&D | Mar 4 | Mar 6 | S | 289 | $321.82 | Sale −$93,006 | 22,694 | Yes | Form 4 |
| Garg PushkalEVP Chief R&D | Mar 4 | Mar 6 | S | 350 | $323.01 | Sale −$113,054 | 22,344 | Yes | Form 4 |
| Garg PushkalEVP Chief R&D | Mar 4 | Mar 6 | S | 767 | $323.84 | Sale −$248,385 | 21,577 | Yes | Form 4 |
| Garg PushkalEVP Chief R&D | Mar 4 | Mar 6 | S | 272 | $324.88 | Sale −$88,367 | 21,305 | Yes | Form 4 |
| Garg PushkalEVP Chief R&D | Mar 4 | Mar 6 | S | 208 | $325.67 | Sale −$67,739 | 21,097 | Yes | Form 4 |
| Fitzgerald Kevin JosephCSO & EVP, Head of Research | Mar 3 | Mar 4 | S | 289 | $316.55 | Sale −$91,483 | 23,223 | Yes | Form 4 |
| Fitzgerald Kevin JosephCSO & EVP, Head of Research | Mar 3 | Mar 4 | S | 282 | $318.62 | Sale −$89,851 | 22,941 | Yes | Form 4 |
| Fitzgerald Kevin JosephCSO & EVP, Head of Research | Mar 3 | Mar 4 | S | 722 | $320.51 | Sale −$231,408 | 22,219 | Yes | Form 4 |
| Fitzgerald Kevin JosephCSO & EVP, Head of Research | Mar 3 | Mar 4 | S | 359 | $321.58 | Sale −$115,447 | 21,860 | Yes | Form 4 |
| Garg PushkalEVP Chief R&D | Mar 3 | Mar 4 | S | 355 | $316.74 | Sale −$112,443 | 24,826 | Yes | Form 4 |
| Garg PushkalEVP Chief R&D | Mar 3 | Mar 4 | S | 317 | $319.06 | Sale −$101,142 | 24,509 | Yes | Form 4 |
| Garg PushkalEVP Chief R&D | Mar 3 | Mar 4 | S | 640 | $320.48 | Sale −$205,107 | 23,869 | Yes | Form 4 |
| Garg PushkalEVP Chief R&D | Mar 3 | Mar 4 | S | 463 | $321.50 | Sale −$148,855 | 23,406 | Yes | Form 4 |
| Greenstreet YvonneChief Executive Officer | Mar 2 | Mar 4 | A | 13,844 | $0.00 | $0 | 105,427 | No | Form 4 |
| Greenstreet YvonneChief Executive Officer | Mar 2 | Mar 4 | S | 200 | $323.62 | Sale −$64,724 | 105,227 | No | Form 4 |
| Greenstreet YvonneChief Executive Officer | Mar 2 | Mar 4 | S | 382 | $324.65 | Sale −$124,016 | 104,845 | No | Form 4 |
| Greenstreet YvonneChief Executive Officer | Mar 2 | Mar 4 | S | 1,098 | $325.63 | Sale −$357,542 | 103,747 | No | Form 4 |
| Greenstreet YvonneChief Executive Officer | Mar 2 | Mar 4 | S | 1,669 | $326.81 | Sale −$545,446 | 102,078 | No | Form 4 |
| Greenstreet YvonneChief Executive Officer | Mar 2 | Mar 4 | S | 1,399 | $327.67 | Sale −$458,410 | 100,679 | No | Form 4 |
| Greenstreet YvonneChief Executive Officer | Mar 2 | Mar 4 | S | 424 | $328.71 | Sale −$139,373 | 100,255 | No | Form 4 |
| Greenstreet YvonneChief Executive Officer | Mar 2 | Mar 4 | S | 722 | $329.71 | Sale −$238,051 | 99,533 | No | Form 4 |
| Greenstreet YvonneChief Executive Officer | Mar 2 | Mar 4 | S | 346 | $330.85 | Sale −$114,474 | 99,187 | No | Form 4 |
| Greenstreet YvonneChief Executive Officer | Mar 2 | Mar 4 | S | 399 | $331.93 | Sale −$132,440 | 98,788 | No | Form 4 |
| Greenstreet YvonneChief Executive Officer | Mar 2 | Mar 4 | S | 160 | $332.64 | Sale −$53,222 | 98,628 | No | Form 4 |
| Greenstreet YvonneChief Executive Officer | Mar 2 | Mar 4 | A · derivative | 30,425 | $325.07 | $9,890,255 | 30,425 | No | Form 4 |
| Greenstreet YvonneChief Executive Officer | Mar 2 | Mar 4 | A · derivative | 110,746 | $0.00 | $0 | 110,746 | No | Form 4 |
| Supran BryanEVP, CLO and Secretary | Mar 2 | Mar 4 | A | 1,539 | $0.00 | $0 | 14,565 | No | Form 4 |
| Supran BryanEVP, CLO and Secretary | Mar 2 | Mar 4 | A · derivative | 3,381 | $325.07 | $1,099,062 | 3,381 | No | Form 4 |
| Tanguler TolgaEVP, Chief Commercial Officer | Mar 2 | Mar 4 | A | 4,769 | $0.00 | $0 | 38,204 | No | Form 4 |
| Tanguler TolgaEVP, Chief Commercial Officer | Mar 2 | Mar 4 | S | 47 | $323.62 | Sale −$15,210 | 38,157 | No | Form 4 |
| Tanguler TolgaEVP, Chief Commercial Officer | Mar 2 | Mar 4 | S | 90 | $324.65 | Sale −$29,219 | 38,067 | No | Form 4 |
| Tanguler TolgaEVP, Chief Commercial Officer | Mar 2 | Mar 4 | S | 258 | $325.63 | Sale −$84,013 | 37,809 | No | Form 4 |
| Tanguler TolgaEVP, Chief Commercial Officer | Mar 2 | Mar 4 | S | 392 | $326.81 | Sale −$128,110 | 37,417 | No | Form 4 |
| Tanguler TolgaEVP, Chief Commercial Officer | Mar 2 | Mar 4 | S | 329 | $327.67 | Sale −$107,803 | 37,088 | No | Form 4 |
| Tanguler TolgaEVP, Chief Commercial Officer | Mar 2 | Mar 4 | S | 100 | $328.71 | Sale −$32,871 | 36,988 | No | Form 4 |
| Tanguler TolgaEVP, Chief Commercial Officer | Mar 2 | Mar 4 | S | 170 | $329.71 | Sale −$56,051 | 36,818 | No | Form 4 |
| Tanguler TolgaEVP, Chief Commercial Officer | Mar 2 | Mar 4 | S | 81 | $330.85 | Sale −$26,799 | 36,737 | No | Form 4 |
| Tanguler TolgaEVP, Chief Commercial Officer | Mar 2 | Mar 4 | S | 94 | $331.93 | Sale −$31,201 | 36,643 | No | Form 4 |
| Tanguler TolgaEVP, Chief Commercial Officer | Mar 2 | Mar 4 | S | 37 | $332.64 | Sale −$12,308 | 36,606 | No | Form 4 |
| Tanguler TolgaEVP, Chief Commercial Officer | Mar 2 | Mar 4 | A · derivative | 10,480 | $325.07 | $3,406,734 | 10,480 | No | Form 4 |
| Fitzgerald Kevin JosephCSO & EVP, Head of Research | Mar 2 | Mar 4 | A | 3,688 | $0.00 | $0 | 25,110 | Yes | Form 4 |
| Fitzgerald Kevin JosephCSO & EVP, Head of Research | Mar 2 | Mar 4 | S | 47 | $323.62 | Sale −$15,210 | 25,063 | Yes | Form 4 |
| Fitzgerald Kevin JosephCSO & EVP, Head of Research | Mar 2 | Mar 4 | S | 90 | $324.65 | Sale −$29,219 | 24,973 | Yes | Form 4 |
| Fitzgerald Kevin JosephCSO & EVP, Head of Research | Mar 2 | Mar 4 | S | 258 | $325.63 | Sale −$84,013 | 24,715 | Yes | Form 4 |
| Fitzgerald Kevin JosephCSO & EVP, Head of Research | Mar 2 | Mar 4 | S | 392 | $326.81 | Sale −$128,110 | 24,323 | Yes | Form 4 |
| Fitzgerald Kevin JosephCSO & EVP, Head of Research | Mar 2 | Mar 4 | S | 329 | $327.67 | Sale −$107,803 | 23,994 | Yes | Form 4 |
| Fitzgerald Kevin JosephCSO & EVP, Head of Research | Mar 2 | Mar 4 | S | 100 | $328.71 | Sale −$32,871 | 23,894 | Yes | Form 4 |
| Fitzgerald Kevin JosephCSO & EVP, Head of Research | Mar 2 | Mar 4 | S | 170 | $329.71 | Sale −$56,051 | 23,724 | Yes | Form 4 |
| Fitzgerald Kevin JosephCSO & EVP, Head of Research | Mar 2 | Mar 4 | S | 81 | $330.85 | Sale −$26,799 | 23,643 | Yes | Form 4 |
| Fitzgerald Kevin JosephCSO & EVP, Head of Research | Mar 2 | Mar 4 | S | 94 | $331.93 | Sale −$31,201 | 23,549 | Yes | Form 4 |
| Fitzgerald Kevin JosephCSO & EVP, Head of Research | Mar 2 | Mar 4 | S | 37 | $332.64 | Sale −$12,308 | 23,512 | Yes | Form 4 |
| Fitzgerald Kevin JosephCSO & EVP, Head of Research | Mar 2 | Mar 4 | A · derivative | 8,105 | $325.07 | $2,634,692 | 8,105 | Yes | Form 4 |
| Garg PushkalEVP Chief R&D | Mar 2 | Mar 4 | A | 4,769 | $0.00 | $0 | 26,898 | Yes | Form 4 |
| Garg PushkalEVP Chief R&D | Mar 2 | Mar 4 | S | 50 | $323.62 | Sale −$16,181 | 26,848 | Yes | Form 4 |
| Garg PushkalEVP Chief R&D | Mar 2 | Mar 4 | S | 97 | $324.65 | Sale −$31,491 | 26,751 | Yes | Form 4 |
| Garg PushkalEVP Chief R&D | Mar 2 | Mar 4 | S | 277 | $325.63 | Sale −$90,200 | 26,474 | Yes | Form 4 |
| Garg PushkalEVP Chief R&D | Mar 2 | Mar 4 | S | 421 | $326.81 | Sale −$137,587 | 26,053 | Yes | Form 4 |
| Garg PushkalEVP Chief R&D | Mar 2 | Mar 4 | S | 353 | $327.67 | Sale −$115,668 | 25,700 | Yes | Form 4 |
| Garg PushkalEVP Chief R&D | Mar 2 | Mar 4 | S | 107 | $328.71 | Sale −$35,172 | 25,593 | Yes | Form 4 |
| Garg PushkalEVP Chief R&D | Mar 2 | Mar 4 | S | 182 | $329.71 | Sale −$60,007 | 25,411 | Yes | Form 4 |
| Garg PushkalEVP Chief R&D | Mar 2 | Mar 4 | S | 87 | $330.85 | Sale −$28,784 | 25,324 | Yes | Form 4 |
| Garg PushkalEVP Chief R&D | Mar 2 | Mar 4 | S | 101 | $331.93 | Sale −$33,525 | 25,223 | Yes | Form 4 |
| Garg PushkalEVP Chief R&D | Mar 2 | Mar 4 | S | 42 | $332.64 | Sale −$13,971 | 25,181 | Yes | Form 4 |
| Garg PushkalEVP Chief R&D | Mar 2 | Mar 4 | A · derivative | 10,480 | $325.07 | $3,406,734 | 10,480 | Yes | Form 4 |
| Poulton Jeffrey V.EVP, Chief Financial Officer | Mar 2 | Mar 4 | A | 4,769 | $0.00 | $0 | 66,479 | No | Form 4 |
| Poulton Jeffrey V.EVP, Chief Financial Officer | Mar 2 | Mar 4 | S | 65 | $323.62 | Sale −$21,035 | 66,414 | No | Form 4 |
| Poulton Jeffrey V.EVP, Chief Financial Officer | Mar 2 | Mar 4 | S | 124 | $324.65 | Sale −$40,257 | 66,290 | No | Form 4 |
| Poulton Jeffrey V.EVP, Chief Financial Officer | Mar 2 | Mar 4 | S | 356 | $325.63 | Sale −$115,924 | 65,934 | No | Form 4 |
| Poulton Jeffrey V.EVP, Chief Financial Officer | Mar 2 | Mar 4 | S | 541 | $326.81 | Sale −$176,804 | 65,393 | No | Form 4 |
| Poulton Jeffrey V.EVP, Chief Financial Officer | Mar 2 | Mar 4 | S | 454 | $327.67 | Sale −$148,762 | 64,939 | No | Form 4 |
| Poulton Jeffrey V.EVP, Chief Financial Officer | Mar 2 | Mar 4 | S | 138 | $328.71 | Sale −$45,362 | 64,801 | No | Form 4 |
| Poulton Jeffrey V.EVP, Chief Financial Officer | Mar 2 | Mar 4 | S | 234 | $329.71 | Sale −$77,152 | 64,567 | No | Form 4 |
| Poulton Jeffrey V.EVP, Chief Financial Officer | Mar 2 | Mar 4 | S | 112 | $330.85 | Sale −$37,055 | 64,455 | No | Form 4 |
| Poulton Jeffrey V.EVP, Chief Financial Officer | Mar 2 | Mar 4 | S | 129 | $331.93 | Sale −$42,819 | 64,326 | No | Form 4 |
| Poulton Jeffrey V.EVP, Chief Financial Officer | Mar 2 | Mar 4 | S | 53 | $332.64 | Sale −$17,630 | 64,273 | No | Form 4 |
| Poulton Jeffrey V.EVP, Chief Financial Officer | Mar 2 | Mar 4 | A · derivative | 10,480 | $325.07 | $3,406,734 | 10,480 | No | Form 4 |
| Garg PushkalEVP Chief R&D | Feb 27 | Mar 2 | M | 1,908 | $0.00 | $0 | 26,756 | Yes | Form 4 |
| Garg PushkalEVP Chief R&D | Feb 27 | Mar 2 | S | 127 | $328.92 | Sale −$41,773 | 26,629 | Yes | Form 4 |
| Garg PushkalEVP Chief R&D | Feb 27 | Mar 2 | S | 2,259 | $330.73 | Sale −$747,119 | 24,370 | Yes | Form 4 |
| Garg PushkalEVP Chief R&D | Feb 27 | Mar 2 | S | 1,159 | $331.49 | Sale −$384,197 | 23,211 | Yes | Form 4 |
| Garg PushkalEVP Chief R&D | Feb 27 | Mar 2 | S | 942 | $332.48 | Sale −$313,196 | 22,269 | Yes | Form 4 |
| Garg PushkalEVP Chief R&D | Feb 27 | Mar 2 | S | 140 | $334.39 | Sale −$46,815 | 22,129 | Yes | Form 4 |
| Garg PushkalEVP Chief R&D | Feb 27 | Mar 2 | M · derivative | 1,908 | $0.00 | $0 | not reported | Yes | Form 4 |
| Tanguler TolgaEVP, Chief Commercial Officer | Feb 27 | Mar 2 | M | 1,666 | $0.00 | $0 | 33,435 | No | Form 4 |
| Tanguler TolgaEVP, Chief Commercial Officer | Feb 27 | Mar 2 | M · derivative | 1,666 | $0.00 | $0 | not reported | No | Form 4 |
| Poulton Jeffrey V.EVP, Chief Financial Officer | Feb 27 | Mar 2 | M | 1,908 | $0.00 | $0 | 61,710 | No | Form 4 |
| Poulton Jeffrey V.EVP, Chief Financial Officer | Feb 27 | Mar 2 | M · derivative | 1,908 | $0.00 | $0 | not reported | No | Form 4 |
| Greenstreet YvonneChief Executive Officer | Feb 27 | Mar 2 | M | 5,921 | $0.00 | $0 | 91,583 | No | Form 4 |
| Greenstreet YvonneChief Executive Officer | Feb 27 | Mar 2 | M · derivative | 5,921 | $0.00 | $0 | not reported | No | Form 4 |
| Fitzgerald Kevin JosephCSO & EVP, Head of Research | Feb 23 | Feb 25 | A | 158 | $0.00 | $0 | 21,422 | No | Form 4 |
| Fitzgerald Kevin JosephCSO & EVP, Head of Research | Feb 17 | Feb 17 | S | 2,041 | $331.96 | Sale −$677,530 | 21,264 | Yes | Form 4 |
| Poulton Jeffrey V.EVP, Chief Financial Officer | Feb 13 | Feb 17 | S | 2,242 | $310.08 | Sale −$695,199 | 59,802 | No | Form 4 |
| Fitzgerald Kevin JosephCSO & EVP, Head of Research | Feb 13 | Feb 17 | S | 1,959 | $310.08 | Sale −$607,447 | 23,305 | Yes | Form 4 |
| Tanguler TolgaEVP, Chief Commercial Officer | Feb 13 | Feb 17 | S | 1,959 | $310.08 | Sale −$607,447 | 31,769 | No | Form 4 |
| Greenstreet YvonneChief Executive Officer | Feb 13 | Feb 17 | S | 6,958 | $310.08 | Sale −$2,157,537 | 85,662 | No | Form 4 |
| Garg PushkalEVP Chief R&D | Feb 13 | Feb 17 | S | 2,242 | $310.08 | Sale −$695,199 | 24,848 | No | Form 4 |
| Poulton Jeffrey V.EVP, Chief Financial Officer | Feb 12 | Feb 17 | A | 4,579 | $0.00 | $0 | 62,044 | No | Form 4 |
| Fitzgerald Kevin JosephCSO & EVP, Head of Research | Feb 12 | Feb 17 | A | 4,000 | $0.00 | $0 | 25,264 | Yes | Form 4 |
| Tanguler TolgaEVP, Chief Commercial Officer | Feb 12 | Feb 17 | A | 4,000 | $0.00 | $0 | 33,728 | No | Form 4 |
| Greenstreet YvonneChief Executive Officer | Feb 12 | Feb 17 | A | 14,209 | $0.00 | $0 | 92,620 | No | Form 4 |
| Garg PushkalEVP Chief R&D | Feb 12 | Feb 17 | A | 4,579 | $0.00 | $0 | 27,090 | No | Form 4 |
| Fitzgerald Kevin JosephCSO & EVP, Head of Research | Jan 13 | Jan 14 | S | 197 | $367.52 | Sale −$72,401 | 23,357 | Yes | Form 4 |
| Fitzgerald Kevin JosephCSO & EVP, Head of Research | Jan 13 | Jan 14 | S | 562 | $368.76 | Sale −$207,243 | 22,795 | Yes | Form 4 |
| Fitzgerald Kevin JosephCSO & EVP, Head of Research | Jan 13 | Jan 14 | S | 644 | $370.00 | Sale −$238,280 | 22,151 | Yes | Form 4 |
| Fitzgerald Kevin JosephCSO & EVP, Head of Research | Jan 13 | Jan 14 | S | 485 | $371.24 | Sale −$180,051 | 21,666 | Yes | Form 4 |
| Fitzgerald Kevin JosephCSO & EVP, Head of Research | Jan 13 | Jan 14 | S | 280 | $372.93 | Sale −$104,420 | 21,386 | Yes | Form 4 |
| Fitzgerald Kevin JosephCSO & EVP, Head of Research | Jan 13 | Jan 14 | S | 122 | $374.33 | Sale −$45,668 | 21,264 | Yes | Form 4 |
| Fitzgerald Kevin JosephCSO & EVP, Head of Research | Jan 12 | Jan 14 | S | 39 | $353.95 | Sale −$13,804 | 25,025 | Yes | Form 4 |
| Fitzgerald Kevin JosephCSO & EVP, Head of Research | Jan 12 | Jan 14 | S | 42 | $355.16 | Sale −$14,917 | 24,983 | Yes | Form 4 |
| Fitzgerald Kevin JosephCSO & EVP, Head of Research | Jan 12 | Jan 14 | S | 41 | $356.09 | Sale −$14,600 | 24,942 | Yes | Form 4 |
| Fitzgerald Kevin JosephCSO & EVP, Head of Research | Jan 12 | Jan 14 | S | 96 | $357.17 | Sale −$34,288 | 24,846 | Yes | Form 4 |
| Fitzgerald Kevin JosephCSO & EVP, Head of Research | Jan 12 | Jan 14 | S | 123 | $358.18 | Sale −$44,056 | 24,723 | Yes | Form 4 |
| Fitzgerald Kevin JosephCSO & EVP, Head of Research | Jan 12 | Jan 14 | S | 85 | $359.14 | Sale −$30,527 | 24,638 | Yes | Form 4 |
| Fitzgerald Kevin JosephCSO & EVP, Head of Research | Jan 12 | Jan 14 | S | 155 | $360.22 | Sale −$55,834 | 24,483 | Yes | Form 4 |
| Fitzgerald Kevin JosephCSO & EVP, Head of Research | Jan 12 | Jan 14 | S | 98 | $361.45 | Sale −$35,422 | 24,385 | Yes | Form 4 |
| Fitzgerald Kevin JosephCSO & EVP, Head of Research | Jan 12 | Jan 14 | S | 73 | $362.38 | Sale −$26,454 | 24,312 | Yes | Form 4 |
| Fitzgerald Kevin JosephCSO & EVP, Head of Research | Jan 12 | Jan 14 | S | 47 | $363.55 | Sale −$17,087 | 24,265 | Yes | Form 4 |
| Fitzgerald Kevin JosephCSO & EVP, Head of Research | Jan 12 | Jan 14 | S | 199 | $364.83 | Sale −$72,601 | 24,066 | Yes | Form 4 |
| Fitzgerald Kevin JosephCSO & EVP, Head of Research | Jan 12 | Jan 14 | S | 220 | $365.56 | Sale −$80,423 | 23,846 | Yes | Form 4 |
| Fitzgerald Kevin JosephCSO & EVP, Head of Research | Jan 12 | Jan 14 | S | 50 | $366.41 | Sale −$18,321 | 23,796 | Yes | Form 4 |
| Fitzgerald Kevin JosephCSO & EVP, Head of Research | Jan 12 | Jan 14 | S | 41 | $367.40 | Sale −$15,063 | 23,755 | Yes | Form 4 |
| Fitzgerald Kevin JosephCSO & EVP, Head of Research | Jan 12 | Jan 14 | S | 92 | $368.62 | Sale −$33,913 | 23,663 | Yes | Form 4 |
| Fitzgerald Kevin JosephCSO & EVP, Head of Research | Jan 12 | Jan 14 | S | 40 | $369.48 | Sale −$14,779 | 23,623 | Yes | Form 4 |
| Fitzgerald Kevin JosephCSO & EVP, Head of Research | Jan 12 | Jan 14 | S | 19 | $370.87 | Sale −$7,047 | 23,604 | Yes | Form 4 |
| Fitzgerald Kevin JosephCSO & EVP, Head of Research | Jan 12 | Jan 14 | S | 2 | $372.46 | Sale −$745 | 23,602 | Yes | Form 4 |
| Fitzgerald Kevin JosephCSO & EVP, Head of Research | Jan 12 | Jan 14 | S | 14 | $374.44 | Sale −$5,242 | 23,588 | Yes | Form 4 |
| Fitzgerald Kevin JosephCSO & EVP, Head of Research | Jan 12 | Jan 14 | S | 19 | $375.65 | Sale −$7,137 | 23,569 | Yes | Form 4 |
| Fitzgerald Kevin JosephCSO & EVP, Head of Research | Jan 12 | Jan 14 | S | 15 | $377.82 | Sale −$5,667 | 23,554 | Yes | Form 4 |
| Tanguler TolgaEVP, Chief Commercial Officer | Jan 12 | Jan 14 | S | 39 | $353.95 | Sale −$13,804 | 31,199 | No | Form 4 |
| Tanguler TolgaEVP, Chief Commercial Officer | Jan 12 | Jan 14 | S | 42 | $355.16 | Sale −$14,917 | 31,157 | No | Form 4 |
| Tanguler TolgaEVP, Chief Commercial Officer | Jan 12 | Jan 14 | S | 41 | $356.09 | Sale −$14,600 | 31,116 | No | Form 4 |
| Tanguler TolgaEVP, Chief Commercial Officer | Jan 12 | Jan 14 | S | 96 | $357.17 | Sale −$34,288 | 31,020 | No | Form 4 |
| Tanguler TolgaEVP, Chief Commercial Officer | Jan 12 | Jan 14 | S | 123 | $358.18 | Sale −$44,056 | 30,897 | No | Form 4 |
| Tanguler TolgaEVP, Chief Commercial Officer | Jan 12 | Jan 14 | S | 85 | $359.14 | Sale −$30,527 | 30,812 | No | Form 4 |
| Tanguler TolgaEVP, Chief Commercial Officer | Jan 12 | Jan 14 | S | 155 | $360.22 | Sale −$55,834 | 30,657 | No | Form 4 |
| Tanguler TolgaEVP, Chief Commercial Officer | Jan 12 | Jan 14 | S | 98 | $361.45 | Sale −$35,422 | 30,559 | No | Form 4 |
| Tanguler TolgaEVP, Chief Commercial Officer | Jan 12 | Jan 14 | S | 73 | $362.38 | Sale −$26,454 | 30,486 | No | Form 4 |
| Tanguler TolgaEVP, Chief Commercial Officer | Jan 12 | Jan 14 | S | 47 | $363.55 | Sale −$17,087 | 30,439 | No | Form 4 |
| Tanguler TolgaEVP, Chief Commercial Officer | Jan 12 | Jan 14 | S | 199 | $364.83 | Sale −$72,601 | 30,240 | No | Form 4 |
| Tanguler TolgaEVP, Chief Commercial Officer | Jan 12 | Jan 14 | S | 220 | $365.56 | Sale −$80,423 | 30,020 | No | Form 4 |
| Tanguler TolgaEVP, Chief Commercial Officer | Jan 12 | Jan 14 | S | 50 | $366.41 | Sale −$18,321 | 29,970 | No | Form 4 |
| Tanguler TolgaEVP, Chief Commercial Officer | Jan 12 | Jan 14 | S | 41 | $367.40 | Sale −$15,063 | 29,929 | No | Form 4 |
| Tanguler TolgaEVP, Chief Commercial Officer | Jan 12 | Jan 14 | S | 92 | $368.62 | Sale −$33,913 | 29,837 | No | Form 4 |
| Tanguler TolgaEVP, Chief Commercial Officer | Jan 12 | Jan 14 | S | 40 | $369.48 | Sale −$14,779 | 29,797 | No | Form 4 |
| Tanguler TolgaEVP, Chief Commercial Officer | Jan 12 | Jan 14 | S | 19 | $370.87 | Sale −$7,047 | 29,778 | No | Form 4 |
| Tanguler TolgaEVP, Chief Commercial Officer | Jan 12 | Jan 14 | S | 2 | $372.46 | Sale −$745 | 29,776 | No | Form 4 |
| Tanguler TolgaEVP, Chief Commercial Officer | Jan 12 | Jan 14 | S | 14 | $374.44 | Sale −$5,242 | 29,762 | No | Form 4 |
| Tanguler TolgaEVP, Chief Commercial Officer | Jan 12 | Jan 14 | S | 19 | $375.65 | Sale −$7,137 | 29,743 | No | Form 4 |
| Tanguler TolgaEVP, Chief Commercial Officer | Jan 12 | Jan 14 | S | 15 | $377.82 | Sale −$5,667 | 29,728 | No | Form 4 |
| Poulton Jeffrey V.EVP, Chief Financial Officer | Jan 12 | Jan 14 | S | 72 | $353.95 | Sale −$25,484 | 60,173 | No | Form 4 |
| Poulton Jeffrey V.EVP, Chief Financial Officer | Jan 12 | Jan 14 | S | 78 | $355.16 | Sale −$27,702 | 60,095 | No | Form 4 |
| Poulton Jeffrey V.EVP, Chief Financial Officer | Jan 12 | Jan 14 | S | 76 | $356.09 | Sale −$27,063 | 60,019 | No | Form 4 |
| Poulton Jeffrey V.EVP, Chief Financial Officer | Jan 12 | Jan 14 | S | 176 | $357.17 | Sale −$62,862 | 59,843 | No | Form 4 |
| Poulton Jeffrey V.EVP, Chief Financial Officer | Jan 12 | Jan 14 | S | 226 | $358.18 | Sale −$80,949 | 59,617 | No | Form 4 |
| Poulton Jeffrey V.EVP, Chief Financial Officer | Jan 12 | Jan 14 | S | 156 | $359.14 | Sale −$56,026 | 59,461 | No | Form 4 |
| Poulton Jeffrey V.EVP, Chief Financial Officer | Jan 12 | Jan 14 | S | 284 | $360.22 | Sale −$102,302 | 59,177 | No | Form 4 |
| Poulton Jeffrey V.EVP, Chief Financial Officer | Jan 12 | Jan 14 | S | 181 | $361.45 | Sale −$65,422 | 58,996 | No | Form 4 |
| Poulton Jeffrey V.EVP, Chief Financial Officer | Jan 12 | Jan 14 | S | 135 | $362.38 | Sale −$48,921 | 58,861 | No | Form 4 |
| Poulton Jeffrey V.EVP, Chief Financial Officer | Jan 12 | Jan 14 | S | 87 | $363.55 | Sale −$31,629 | 58,774 | No | Form 4 |
| Poulton Jeffrey V.EVP, Chief Financial Officer | Jan 12 | Jan 14 | S | 365 | $364.83 | Sale −$133,163 | 58,409 | No | Form 4 |
| Poulton Jeffrey V.EVP, Chief Financial Officer | Jan 12 | Jan 14 | S | 405 | $365.56 | Sale −$148,052 | 58,004 | No | Form 4 |
| Poulton Jeffrey V.EVP, Chief Financial Officer | Jan 12 | Jan 14 | S | 92 | $366.41 | Sale −$33,710 | 57,912 | No | Form 4 |
| Poulton Jeffrey V.EVP, Chief Financial Officer | Jan 12 | Jan 14 | S | 76 | $367.40 | Sale −$27,922 | 57,836 | No | Form 4 |
| Poulton Jeffrey V.EVP, Chief Financial Officer | Jan 12 | Jan 14 | S | 170 | $368.62 | Sale −$62,665 | 57,666 | No | Form 4 |
| Poulton Jeffrey V.EVP, Chief Financial Officer | Jan 12 | Jan 14 | S | 73 | $369.48 | Sale −$26,972 | 57,593 | No | Form 4 |
| Poulton Jeffrey V.EVP, Chief Financial Officer | Jan 12 | Jan 14 | S | 36 | $370.87 | Sale −$13,351 | 57,557 | No | Form 4 |
| Poulton Jeffrey V.EVP, Chief Financial Officer | Jan 12 | Jan 14 | S | 6 | $372.46 | Sale −$2,235 | 57,551 | No | Form 4 |
| Poulton Jeffrey V.EVP, Chief Financial Officer | Jan 12 | Jan 14 | S | 25 | $374.44 | Sale −$9,361 | 57,526 | No | Form 4 |
| Poulton Jeffrey V.EVP, Chief Financial Officer | Jan 12 | Jan 14 | S | 34 | $375.65 | Sale −$12,772 | 57,492 | No | Form 4 |
| Poulton Jeffrey V.EVP, Chief Financial Officer | Jan 12 | Jan 14 | S | 27 | $377.82 | Sale −$10,201 | 57,465 | No | Form 4 |
| Greenstreet YvonneChief Executive Officer | Jan 12 | Jan 14 | S | 247 | $353.95 | Sale −$87,426 | 87,741 | No | Form 4 |
| Greenstreet YvonneChief Executive Officer | Jan 12 | Jan 14 | S | 269 | $355.16 | Sale −$95,538 | 87,472 | No | Form 4 |
| Greenstreet YvonneChief Executive Officer | Jan 12 | Jan 14 | S | 263 | $356.09 | Sale −$93,652 | 87,209 | No | Form 4 |
| Greenstreet YvonneChief Executive Officer | Jan 12 | Jan 14 | S | 607 | $357.17 | Sale −$216,802 | 86,602 | No | Form 4 |
| Greenstreet YvonneChief Executive Officer | Jan 12 | Jan 14 | S | 778 | $358.18 | Sale −$278,664 | 85,824 | No | Form 4 |
| Greenstreet YvonneChief Executive Officer | Jan 12 | Jan 14 | S | 537 | $359.14 | Sale −$192,858 | 85,287 | No | Form 4 |
| Greenstreet YvonneChief Executive Officer | Jan 12 | Jan 14 | S | 980 | $360.22 | Sale −$353,016 | 84,307 | No | Form 4 |
| Greenstreet YvonneChief Executive Officer | Jan 12 | Jan 14 | S | 624 | $361.45 | Sale −$225,545 | 83,683 | No | Form 4 |
| Greenstreet YvonneChief Executive Officer | Jan 12 | Jan 14 | S | 464 | $362.38 | Sale −$168,144 | 83,219 | No | Form 4 |
| Greenstreet YvonneChief Executive Officer | Jan 12 | Jan 14 | S | 301 | $363.55 | Sale −$109,429 | 82,918 | No | Form 4 |
| Greenstreet YvonneChief Executive Officer | Jan 12 | Jan 14 | S | 1,259 | $364.83 | Sale −$459,321 | 81,659 | No | Form 4 |
| Greenstreet YvonneChief Executive Officer | Jan 12 | Jan 14 | S | 1,395 | $365.56 | Sale −$509,956 | 80,264 | No | Form 4 |
| Greenstreet YvonneChief Executive Officer | Jan 12 | Jan 14 | S | 316 | $366.41 | Sale −$115,786 | 79,948 | No | Form 4 |
| Greenstreet YvonneChief Executive Officer | Jan 12 | Jan 14 | S | 261 | $367.40 | Sale −$95,891 | 79,687 | No | Form 4 |
| Greenstreet YvonneChief Executive Officer | Jan 12 | Jan 14 | S | 584 | $368.62 | Sale −$215,274 | 79,103 | No | Form 4 |
| Greenstreet YvonneChief Executive Officer | Jan 12 | Jan 14 | S | 253 | $369.48 | Sale −$93,478 | 78,850 | No | Form 4 |
| Greenstreet YvonneChief Executive Officer | Jan 12 | Jan 14 | S | 118 | $370.87 | Sale −$43,763 | 78,732 | No | Form 4 |
| Greenstreet YvonneChief Executive Officer | Jan 12 | Jan 14 | S | 21 | $372.46 | Sale −$7,822 | 78,711 | No | Form 4 |
| Greenstreet YvonneChief Executive Officer | Jan 12 | Jan 14 | S | 88 | $374.44 | Sale −$32,951 | 78,623 | No | Form 4 |
| Greenstreet YvonneChief Executive Officer | Jan 12 | Jan 14 | S | 118 | $375.65 | Sale −$44,327 | 78,505 | No | Form 4 |
| Greenstreet YvonneChief Executive Officer | Jan 12 | Jan 14 | S | 94 | $377.82 | Sale −$35,515 | 78,411 | No | Form 4 |
| Garg PushkalEVP Chief R&D | Jan 12 | Jan 14 | S | 39 | $353.95 | Sale −$13,804 | 23,982 | No | Form 4 |
| Garg PushkalEVP Chief R&D | Jan 12 | Jan 14 | S | 42 | $355.16 | Sale −$14,917 | 23,940 | No | Form 4 |
| Garg PushkalEVP Chief R&D | Jan 12 | Jan 14 | S | 41 | $356.09 | Sale −$14,600 | 23,899 | No | Form 4 |
| Garg PushkalEVP Chief R&D | Jan 12 | Jan 14 | S | 96 | $357.17 | Sale −$34,288 | 23,803 | No | Form 4 |
| Garg PushkalEVP Chief R&D | Jan 12 | Jan 14 | S | 123 | $358.18 | Sale −$44,056 | 23,680 | No | Form 4 |
| Garg PushkalEVP Chief R&D | Jan 12 | Jan 14 | S | 85 | $359.14 | Sale −$30,527 | 23,595 | No | Form 4 |
| Garg PushkalEVP Chief R&D | Jan 12 | Jan 14 | S | 155 | $360.22 | Sale −$55,834 | 23,440 | No | Form 4 |
| Garg PushkalEVP Chief R&D | Jan 12 | Jan 14 | S | 98 | $361.45 | Sale −$35,422 | 23,342 | No | Form 4 |
| Garg PushkalEVP Chief R&D | Jan 12 | Jan 14 | S | 73 | $362.38 | Sale −$26,454 | 23,269 | No | Form 4 |
| Garg PushkalEVP Chief R&D | Jan 12 | Jan 14 | S | 47 | $363.55 | Sale −$17,087 | 23,222 | No | Form 4 |
| Garg PushkalEVP Chief R&D | Jan 12 | Jan 14 | S | 199 | $364.83 | Sale −$72,601 | 23,023 | No | Form 4 |
| Garg PushkalEVP Chief R&D | Jan 12 | Jan 14 | S | 220 | $365.56 | Sale −$80,423 | 22,803 | No | Form 4 |
| Garg PushkalEVP Chief R&D | Jan 12 | Jan 14 | S | 50 | $366.41 | Sale −$18,321 | 22,753 | No | Form 4 |
| Garg PushkalEVP Chief R&D | Jan 12 | Jan 14 | S | 41 | $367.40 | Sale −$15,063 | 22,712 | No | Form 4 |
| Garg PushkalEVP Chief R&D | Jan 12 | Jan 14 | S | 92 | $368.62 | Sale −$33,913 | 22,620 | No | Form 4 |
| Garg PushkalEVP Chief R&D | Jan 12 | Jan 14 | S | 40 | $369.48 | Sale −$14,779 | 22,580 | No | Form 4 |
| Garg PushkalEVP Chief R&D | Jan 12 | Jan 14 | S | 18 | $370.87 | Sale −$6,676 | 22,562 | No | Form 4 |
| Garg PushkalEVP Chief R&D | Jan 12 | Jan 14 | S | 3 | $372.46 | Sale −$1,117 | 22,559 | No | Form 4 |
| Garg PushkalEVP Chief R&D | Jan 12 | Jan 14 | S | 14 | $374.44 | Sale −$5,242 | 22,545 | No | Form 4 |
| Garg PushkalEVP Chief R&D | Jan 12 | Jan 14 | S | 19 | $375.65 | Sale −$7,137 | 22,526 | No | Form 4 |
| Garg PushkalEVP Chief R&D | Jan 12 | Jan 14 | S | 15 | $377.82 | Sale −$5,667 | 22,511 | No | Form 4 |
| Fitzgerald Kevin JosephCSO & EVP, Head of Research | Jan 11 | Jan 14 | A | 3,800 | $0.00 | $0 | 25,064 | Yes | Form 4 |
| Tanguler TolgaEVP, Chief Commercial Officer | Jan 11 | Jan 14 | A | 3,800 | $0.00 | $0 | 31,238 | No | Form 4 |
| Poulton Jeffrey V.EVP, Chief Financial Officer | Jan 11 | Jan 14 | A | 6,193 | $0.00 | $0 | 60,245 | No | Form 4 |
| Greenstreet YvonneChief Executive Officer | Jan 11 | Jan 14 | A | 19,003 | $0.00 | $0 | 87,988 | No | Form 4 |
| Garg PushkalEVP Chief R&D | Jan 11 | Jan 14 | A | 3,800 | $0.00 | $0 | 24,021 | No | Form 4 |
| Arbuckle Stuart A | Jan 5 | Jan 7 | A · derivative | 3,279 | $397.83 | $1,304,485 | 3,279 | No | Form 4 |
| Greenstreet YvonneChief Executive Officer | Nov 26, 2025 | Dec 1, 2025 | M | 839 | $119.13 | $99,950 | 66,248 | No | Form 4 |
| Greenstreet YvonneChief Executive Officer | Nov 26, 2025 | Dec 1, 2025 | M | 2,352 | $85.00 | $199,920 | 68,600 | No | Form 4 |
| Greenstreet YvonneChief Executive Officer | Nov 26, 2025 | Dec 1, 2025 | M | 847 | $118.05 | $99,988 | 69,447 | No | Form 4 |
| Greenstreet YvonneChief Executive Officer | Nov 26, 2025 | Dec 1, 2025 | M | 659 | $151.59 | $99,898 | 70,106 | No | Form 4 |
| Greenstreet YvonneChief Executive Officer | Nov 26, 2025 | Dec 1, 2025 | F | 1,121 | $445.12 | $498,980 | 68,985 | No | Form 4 |
| Greenstreet YvonneChief Executive Officer | Nov 26, 2025 | Dec 1, 2025 | M · derivative | 2,352 | $85.00 | $199,920 | not reported | No | Form 4 |
| Greenstreet YvonneChief Executive Officer | Nov 26, 2025 | Dec 1, 2025 | M · derivative | 847 | $118.05 | $99,988 | not reported | No | Form 4 |
| Greenstreet YvonneChief Executive Officer | Nov 26, 2025 | Dec 1, 2025 | M · derivative | 839 | $119.13 | $99,950 | not reported | No | Form 4 |
| Greenstreet YvonneChief Executive Officer | Nov 26, 2025 | Dec 1, 2025 | M · derivative | 659 | $151.59 | $99,898 | 28,141 | No | Form 4 |
| Fitzgerald Kevin JosephCSO & EVP, Head of Research | Nov 17, 2025 | Nov 19, 2025 | M | 8,161 | $119.13 | $972,220 | 33,392 | Yes | Form 4 |
| Fitzgerald Kevin JosephCSO & EVP, Head of Research | Nov 17, 2025 | Nov 19, 2025 | S | 8,168 | $449.00 | Sale −$3,667,432 | 25,224 | Yes | Form 4 |
| Fitzgerald Kevin JosephCSO & EVP, Head of Research | Nov 17, 2025 | Nov 19, 2025 | S | 96 | $450.09 | Sale −$43,209 | 25,128 | Yes | Form 4 |
| Fitzgerald Kevin JosephCSO & EVP, Head of Research | Nov 17, 2025 | Nov 19, 2025 | S | 129 | $451.51 | Sale −$58,245 | 24,999 | Yes | Form 4 |
| Fitzgerald Kevin JosephCSO & EVP, Head of Research | Nov 17, 2025 | Nov 19, 2025 | S | 368 | $455.24 | Sale −$167,528 | 24,631 | Yes | Form 4 |
| Fitzgerald Kevin JosephCSO & EVP, Head of Research | Nov 17, 2025 | Nov 19, 2025 | S | 364 | $456.25 | Sale −$166,075 | 24,267 | Yes | Form 4 |
| Fitzgerald Kevin JosephCSO & EVP, Head of Research | Nov 17, 2025 | Nov 19, 2025 | S | 262 | $457.39 | Sale −$119,836 | 24,005 | Yes | Form 4 |
| Fitzgerald Kevin JosephCSO & EVP, Head of Research | Nov 17, 2025 | Nov 19, 2025 | S | 794 | $458.41 | Sale −$363,978 | 23,211 | Yes | Form 4 |
| Fitzgerald Kevin JosephCSO & EVP, Head of Research | Nov 17, 2025 | Nov 19, 2025 | S | 622 | $459.89 | Sale −$286,052 | 22,589 | Yes | Form 4 |
| Fitzgerald Kevin JosephCSO & EVP, Head of Research | Nov 17, 2025 | Nov 19, 2025 | S | 707 | $460.84 | Sale −$325,814 | 21,882 | Yes | Form 4 |
| Fitzgerald Kevin JosephCSO & EVP, Head of Research | Nov 17, 2025 | Nov 19, 2025 | S | 323 | $461.96 | Sale −$149,213 | 21,559 | Yes | Form 4 |
| Fitzgerald Kevin JosephCSO & EVP, Head of Research | Nov 17, 2025 | Nov 19, 2025 | S | 295 | $463.08 | Sale −$136,609 | 21,264 | Yes | Form 4 |
| Fitzgerald Kevin JosephCSO & EVP, Head of Research | Nov 17, 2025 | Nov 19, 2025 | M · derivative | 8,161 | $119.13 | $972,220 | 839 | Yes | Form 4 |
| Greenstreet YvonneChief Executive Officer | Nov 13, 2025 | Nov 14, 2025 | M | 10,000 | $119.13 | $1,191,300 | 75,409 | Yes | Form 4 |
| Greenstreet YvonneChief Executive Officer | Nov 13, 2025 | Nov 14, 2025 | S | 654 | $447.73 | Sale −$292,815 | 74,755 | Yes | Form 4 |
| Greenstreet YvonneChief Executive Officer | Nov 13, 2025 | Nov 14, 2025 | S | 1,013 | $448.76 | Sale −$454,594 | 73,742 | Yes | Form 4 |
| Greenstreet YvonneChief Executive Officer | Nov 13, 2025 | Nov 14, 2025 | S | 1,477 | $450.02 | Sale −$664,680 | 72,265 | Yes | Form 4 |
| Greenstreet YvonneChief Executive Officer | Nov 13, 2025 | Nov 14, 2025 | S | 2,218 | $450.69 | Sale −$999,630 | 70,047 | Yes | Form 4 |
| Greenstreet YvonneChief Executive Officer | Nov 13, 2025 | Nov 14, 2025 | S | 1,702 | $451.94 | Sale −$769,202 | 68,345 | Yes | Form 4 |
| Greenstreet YvonneChief Executive Officer | Nov 13, 2025 | Nov 14, 2025 | S | 1,599 | $452.85 | Sale −$724,107 | 66,746 | Yes | Form 4 |
| Greenstreet YvonneChief Executive Officer | Nov 13, 2025 | Nov 14, 2025 | S | 881 | $453.99 | Sale −$399,965 | 65,865 | Yes | Form 4 |
| Greenstreet YvonneChief Executive Officer | Nov 13, 2025 | Nov 14, 2025 | S | 195 | $454.69 | Sale −$88,665 | 65,670 | Yes | Form 4 |
| Greenstreet YvonneChief Executive Officer | Nov 13, 2025 | Nov 14, 2025 | S | 261 | $456.03 | Sale −$119,024 | 65,409 | Yes | Form 4 |
| Greenstreet YvonneChief Executive Officer | Nov 13, 2025 | Nov 14, 2025 | M · derivative | 10,000 | $119.13 | $1,191,300 | not reported | Yes | Form 4 |
| Greenstreet YvonneChief Executive Officer | Nov 12, 2025 | Nov 14, 2025 | M | 650 | $42.22 | $27,443 | 66,059 | Yes | Form 4 |
| Greenstreet YvonneChief Executive Officer | Nov 12, 2025 | Nov 14, 2025 | M | 15,000 | $119.13 | $1,786,950 | 81,059 | Yes | Form 4 |
| Greenstreet YvonneChief Executive Officer | Nov 12, 2025 | Nov 14, 2025 | S | 711 | $448.07 | Sale −$318,578 | 80,348 | Yes | Form 4 |
| Greenstreet YvonneChief Executive Officer | Nov 12, 2025 | Nov 14, 2025 | S | 2,132 | $449.15 | Sale −$957,588 | 78,216 | Yes | Form 4 |
| Greenstreet YvonneChief Executive Officer | Nov 12, 2025 | Nov 14, 2025 | S | 453 | $450.17 | Sale −$203,927 | 77,763 | Yes | Form 4 |
| Greenstreet YvonneChief Executive Officer | Nov 12, 2025 | Nov 14, 2025 | S | 1,255 | $451.16 | Sale −$566,206 | 76,508 | Yes | Form 4 |
| Greenstreet YvonneChief Executive Officer | Nov 12, 2025 | Nov 14, 2025 | S | 1,210 | $452.43 | Sale −$547,440 | 75,298 | Yes | Form 4 |
| Greenstreet YvonneChief Executive Officer | Nov 12, 2025 | Nov 14, 2025 | S | 1,069 | $453.52 | Sale −$484,813 | 74,229 | Yes | Form 4 |
| Greenstreet YvonneChief Executive Officer | Nov 12, 2025 | Nov 14, 2025 | S | 1,960 | $454.84 | Sale −$891,486 | 72,269 | Yes | Form 4 |
| Greenstreet YvonneChief Executive Officer | Nov 12, 2025 | Nov 14, 2025 | S | 3,406 | $455.56 | Sale −$1,551,637 | 68,863 | Yes | Form 4 |
| Greenstreet YvonneChief Executive Officer | Nov 12, 2025 | Nov 14, 2025 | S | 2,420 | $456.64 | Sale −$1,105,069 | 66,443 | Yes | Form 4 |
| Greenstreet YvonneChief Executive Officer | Nov 12, 2025 | Nov 14, 2025 | S | 604 | $457.71 | Sale −$276,457 | 65,839 | Yes | Form 4 |
| Greenstreet YvonneChief Executive Officer | Nov 12, 2025 | Nov 14, 2025 | S | 430 | $458.42 | Sale −$197,121 | 65,409 | Yes | Form 4 |
| Greenstreet YvonneChief Executive Officer | Nov 12, 2025 | Nov 14, 2025 | M · derivative | 650 | $42.22 | $27,443 | not reported | Yes | Form 4 |
| Greenstreet YvonneChief Executive Officer | Nov 12, 2025 | Nov 14, 2025 | M · derivative | 15,000 | $119.13 | $1,786,950 | 10,000 | Yes | Form 4 |
| Garg PushkalEVP Chief R&D | Oct 3, 2025 | Oct 3, 2025 | S | 682 | $449.99 | Sale −$306,893 | 22,561 | Yes | Form 4 |
| Garg PushkalEVP Chief R&D | Oct 3, 2025 | Oct 3, 2025 | S | 810 | $450.63 | Sale −$365,010 | 21,751 | Yes | Form 4 |
| Garg PushkalEVP Chief R&D | Oct 3, 2025 | Oct 3, 2025 | S | 898 | $451.76 | Sale −$405,680 | 20,853 | Yes | Form 4 |
| Garg PushkalEVP Chief R&D | Oct 3, 2025 | Oct 3, 2025 | S | 417 | $453.51 | Sale −$189,114 | 20,436 | Yes | Form 4 |
| Garg PushkalEVP Chief R&D | Oct 3, 2025 | Oct 3, 2025 | S | 215 | $454.37 | Sale −$97,690 | 20,221 | Yes | Form 4 |
| Garg PushkalEVP Chief R&D | Oct 2, 2025 | Oct 3, 2025 | S | 115 | $446.53 | Sale −$51,351 | 26,065 | Yes | Form 4 |
| Garg PushkalEVP Chief R&D | Oct 2, 2025 | Oct 3, 2025 | S | 56 | $447.92 | Sale −$25,084 | 26,009 | Yes | Form 4 |
| Garg PushkalEVP Chief R&D | Oct 2, 2025 | Oct 3, 2025 | S | 180 | $448.77 | Sale −$80,779 | 25,829 | Yes | Form 4 |
| Garg PushkalEVP Chief R&D | Oct 2, 2025 | Oct 3, 2025 | S | 249 | $449.79 | Sale −$111,998 | 25,580 | Yes | Form 4 |
| Garg PushkalEVP Chief R&D | Oct 2, 2025 | Oct 3, 2025 | S | 541 | $450.81 | Sale −$243,888 | 25,039 | Yes | Form 4 |
| Garg PushkalEVP Chief R&D | Oct 2, 2025 | Oct 3, 2025 | S | 332 | $451.86 | Sale −$150,018 | 24,707 | Yes | Form 4 |
| Garg PushkalEVP Chief R&D | Oct 2, 2025 | Oct 3, 2025 | S | 668 | $452.69 | Sale −$302,397 | 24,039 | Yes | Form 4 |
| Garg PushkalEVP Chief R&D | Oct 2, 2025 | Oct 3, 2025 | S | 329 | $453.77 | Sale −$149,290 | 23,710 | Yes | Form 4 |
| Garg PushkalEVP Chief R&D | Oct 2, 2025 | Oct 3, 2025 | S | 244 | $454.84 | Sale −$110,981 | 23,466 | Yes | Form 4 |
| Garg PushkalEVP Chief R&D | Oct 2, 2025 | Oct 3, 2025 | S | 73 | $455.82 | Sale −$33,275 | 23,393 | Yes | Form 4 |
| Garg PushkalEVP Chief R&D | Oct 2, 2025 | Oct 3, 2025 | S | 147 | $457.43 | Sale −$67,242 | 23,246 | Yes | Form 4 |
| Garg PushkalEVP Chief R&D | Oct 2, 2025 | Oct 3, 2025 | S | 3 | $457.64 | Sale −$1,373 | 23,243 | Yes | Form 4 |
| Fitzgerald Kevin JosephCSO & EVP, Head of Research | Oct 2, 2025 | Oct 3, 2025 | S | 96 | $446.53 | Sale −$42,867 | 27,576 | No | Form 4 |
| Fitzgerald Kevin JosephCSO & EVP, Head of Research | Oct 2, 2025 | Oct 3, 2025 | S | 47 | $447.92 | Sale −$21,052 | 27,529 | No | Form 4 |
| Fitzgerald Kevin JosephCSO & EVP, Head of Research | Oct 2, 2025 | Oct 3, 2025 | S | 150 | $448.77 | Sale −$67,316 | 27,379 | No | Form 4 |
| Fitzgerald Kevin JosephCSO & EVP, Head of Research | Oct 2, 2025 | Oct 3, 2025 | S | 207 | $449.79 | Sale −$93,107 | 27,172 | No | Form 4 |
| Fitzgerald Kevin JosephCSO & EVP, Head of Research | Oct 2, 2025 | Oct 3, 2025 | S | 449 | $450.81 | Sale −$202,414 | 26,723 | No | Form 4 |
| Fitzgerald Kevin JosephCSO & EVP, Head of Research | Oct 2, 2025 | Oct 3, 2025 | S | 276 | $451.86 | Sale −$124,713 | 26,447 | No | Form 4 |
| Fitzgerald Kevin JosephCSO & EVP, Head of Research | Oct 2, 2025 | Oct 3, 2025 | S | 555 | $452.69 | Sale −$251,243 | 25,892 | No | Form 4 |
| Fitzgerald Kevin JosephCSO & EVP, Head of Research | Oct 2, 2025 | Oct 3, 2025 | S | 273 | $453.77 | Sale −$123,879 | 25,619 | No | Form 4 |
| Fitzgerald Kevin JosephCSO & EVP, Head of Research | Oct 2, 2025 | Oct 3, 2025 | S | 203 | $454.84 | Sale −$92,333 | 25,416 | No | Form 4 |
| Fitzgerald Kevin JosephCSO & EVP, Head of Research | Oct 2, 2025 | Oct 3, 2025 | S | 60 | $455.82 | Sale −$27,349 | 25,356 | No | Form 4 |
| Fitzgerald Kevin JosephCSO & EVP, Head of Research | Oct 2, 2025 | Oct 3, 2025 | S | 122 | $457.43 | Sale −$55,806 | 25,234 | No | Form 4 |
| Fitzgerald Kevin JosephCSO & EVP, Head of Research | Oct 2, 2025 | Oct 3, 2025 | S | 3 | $457.64 | Sale −$1,373 | 25,231 | No | Form 4 |
| Tanguler TolgaEVP, Chief Commercial Officer | Oct 2, 2025 | Oct 3, 2025 | S | 55 | $446.53 | Sale −$24,559 | 28,788 | No | Form 4 |
| Tanguler TolgaEVP, Chief Commercial Officer | Oct 2, 2025 | Oct 3, 2025 | S | 27 | $447.92 | Sale −$12,094 | 28,761 | No | Form 4 |
| Tanguler TolgaEVP, Chief Commercial Officer | Oct 2, 2025 | Oct 3, 2025 | S | 86 | $448.77 | Sale −$38,594 | 28,675 | No | Form 4 |
| Tanguler TolgaEVP, Chief Commercial Officer | Oct 2, 2025 | Oct 3, 2025 | S | 119 | $449.79 | Sale −$53,525 | 28,556 | No | Form 4 |
| Tanguler TolgaEVP, Chief Commercial Officer | Oct 2, 2025 | Oct 3, 2025 | S | 260 | $450.81 | Sale −$117,211 | 28,296 | No | Form 4 |
| Tanguler TolgaEVP, Chief Commercial Officer | Oct 2, 2025 | Oct 3, 2025 | S | 159 | $451.86 | Sale −$71,846 | 28,137 | No | Form 4 |
| Tanguler TolgaEVP, Chief Commercial Officer | Oct 2, 2025 | Oct 3, 2025 | S | 319 | $452.69 | Sale −$144,408 | 27,818 | No | Form 4 |
| Tanguler TolgaEVP, Chief Commercial Officer | Oct 2, 2025 | Oct 3, 2025 | S | 157 | $453.77 | Sale −$71,242 | 27,661 | No | Form 4 |
| Tanguler TolgaEVP, Chief Commercial Officer | Oct 2, 2025 | Oct 3, 2025 | S | 117 | $454.84 | Sale −$53,216 | 27,544 | No | Form 4 |
| Tanguler TolgaEVP, Chief Commercial Officer | Oct 2, 2025 | Oct 3, 2025 | S | 35 | $455.82 | Sale −$15,954 | 27,509 | No | Form 4 |
| Tanguler TolgaEVP, Chief Commercial Officer | Oct 2, 2025 | Oct 3, 2025 | S | 70 | $457.43 | Sale −$32,020 | 27,439 | No | Form 4 |
| Tanguler TolgaEVP, Chief Commercial Officer | Oct 2, 2025 | Oct 3, 2025 | S | 1 | $457.64 | Sale −$458 | 27,438 | No | Form 4 |
| Greenstreet YvonneChief Executive Officer | Oct 2, 2025 | Oct 3, 2025 | S | 350 | $446.53 | Sale −$156,286 | 73,983 | No | Form 4 |
| Greenstreet YvonneChief Executive Officer | Oct 2, 2025 | Oct 3, 2025 | S | 171 | $447.92 | Sale −$76,594 | 73,812 | No | Form 4 |
| Greenstreet YvonneChief Executive Officer | Oct 2, 2025 | Oct 3, 2025 | S | 548 | $448.77 | Sale −$245,926 | 73,264 | No | Form 4 |
| Greenstreet YvonneChief Executive Officer | Oct 2, 2025 | Oct 3, 2025 | S | 758 | $449.79 | Sale −$340,941 | 72,506 | No | Form 4 |
| Greenstreet YvonneChief Executive Officer | Oct 2, 2025 | Oct 3, 2025 | S | 1,642 | $450.81 | Sale −$740,230 | 70,864 | No | Form 4 |
| Greenstreet YvonneChief Executive Officer | Oct 2, 2025 | Oct 3, 2025 | S | 1,010 | $451.86 | Sale −$456,379 | 69,854 | No | Form 4 |
| Greenstreet YvonneChief Executive Officer | Oct 2, 2025 | Oct 3, 2025 | S | 2,029 | $452.69 | Sale −$918,508 | 67,825 | No | Form 4 |
| Greenstreet YvonneChief Executive Officer | Oct 2, 2025 | Oct 3, 2025 | S | 999 | $453.77 | Sale −$453,316 | 66,826 | No | Form 4 |
| Greenstreet YvonneChief Executive Officer | Oct 2, 2025 | Oct 3, 2025 | S | 741 | $454.84 | Sale −$337,036 | 66,085 | No | Form 4 |
| Greenstreet YvonneChief Executive Officer | Oct 2, 2025 | Oct 3, 2025 | S | 221 | $455.82 | Sale −$100,736 | 65,864 | No | Form 4 |
| Greenstreet YvonneChief Executive Officer | Oct 2, 2025 | Oct 3, 2025 | S | 446 | $457.43 | Sale −$204,014 | 65,418 | No | Form 4 |
| Greenstreet YvonneChief Executive Officer | Oct 2, 2025 | Oct 3, 2025 | S | 9 | $457.64 | Sale −$4,119 | 65,409 | No | Form 4 |
| Poulton Jeffrey V.EVP, Chief Financial Officer | Oct 2, 2025 | Oct 3, 2025 | S | 150 | $446.53 | Sale −$66,980 | 57,723 | No | Form 4 |
| Poulton Jeffrey V.EVP, Chief Financial Officer | Oct 2, 2025 | Oct 3, 2025 | S | 73 | $447.92 | Sale −$32,698 | 57,650 | No | Form 4 |
| Poulton Jeffrey V.EVP, Chief Financial Officer | Oct 2, 2025 | Oct 3, 2025 | S | 234 | $448.77 | Sale −$105,012 | 57,416 | No | Form 4 |
| Poulton Jeffrey V.EVP, Chief Financial Officer | Oct 2, 2025 | Oct 3, 2025 | S | 324 | $449.79 | Sale −$145,732 | 57,092 | No | Form 4 |
| Poulton Jeffrey V.EVP, Chief Financial Officer | Oct 2, 2025 | Oct 3, 2025 | S | 704 | $450.81 | Sale −$317,370 | 56,388 | No | Form 4 |
| Poulton Jeffrey V.EVP, Chief Financial Officer | Oct 2, 2025 | Oct 3, 2025 | S | 432 | $451.86 | Sale −$195,204 | 55,956 | No | Form 4 |
| Poulton Jeffrey V.EVP, Chief Financial Officer | Oct 2, 2025 | Oct 3, 2025 | S | 869 | $452.69 | Sale −$393,388 | 55,087 | No | Form 4 |
| Poulton Jeffrey V.EVP, Chief Financial Officer | Oct 2, 2025 | Oct 3, 2025 | S | 428 | $453.77 | Sale −$194,214 | 54,659 | No | Form 4 |
| Poulton Jeffrey V.EVP, Chief Financial Officer | Oct 2, 2025 | Oct 3, 2025 | S | 317 | $454.84 | Sale −$144,184 | 54,342 | No | Form 4 |
| Poulton Jeffrey V.EVP, Chief Financial Officer | Oct 2, 2025 | Oct 3, 2025 | S | 95 | $455.82 | Sale −$43,303 | 54,247 | No | Form 4 |
| Poulton Jeffrey V.EVP, Chief Financial Officer | Oct 2, 2025 | Oct 3, 2025 | S | 191 | $457.43 | Sale −$87,369 | 54,056 | No | Form 4 |
| Poulton Jeffrey V.EVP, Chief Financial Officer | Oct 2, 2025 | Oct 3, 2025 | S | 4 | $457.64 | Sale −$1,831 | 54,052 | No | Form 4 |
| Garg PushkalEVP Chief R&D | Oct 1, 2025 | Oct 3, 2025 | A | 3,108 | $0.00 | $0 | 23,329 | Yes | Form 4 |
| Garg PushkalEVP Chief R&D | Oct 1, 2025 | Oct 3, 2025 | A | 2,851 | $0.00 | $0 | 26,180 | Yes | Form 4 |
| Fitzgerald Kevin JosephCSO & EVP, Head of Research | Oct 1, 2025 | Oct 3, 2025 | A | 2,102 | $0.00 | $0 | 24,821 | No | Form 4 |
| Fitzgerald Kevin JosephCSO & EVP, Head of Research | Oct 1, 2025 | Oct 3, 2025 | A | 2,851 | $0.00 | $0 | 27,672 | No | Form 4 |
| Tanguler TolgaEVP, Chief Commercial Officer | Oct 1, 2025 | Oct 3, 2025 | A | 2,851 | $0.00 | $0 | 28,843 | No | Form 4 |
| Greenstreet YvonneChief Executive Officer | Oct 1, 2025 | Oct 3, 2025 | A | 3,860 | $0.00 | $0 | 60,081 | No | Form 4 |
| Greenstreet YvonneChief Executive Officer | Oct 1, 2025 | Oct 3, 2025 | A | 14,252 | $0.00 | $0 | 74,333 | No | Form 4 |
| Poulton Jeffrey V.EVP, Chief Financial Officer | Oct 1, 2025 | Oct 3, 2025 | A | 3,108 | $0.00 | $0 | 53,229 | No | Form 4 |
| Poulton Jeffrey V.EVP, Chief Financial Officer | Oct 1, 2025 | Oct 3, 2025 | A | 4,644 | $0.00 | $0 | 57,873 | No | Form 4 |
| Supran BryanEVP, CLO and Secretary | Oct 1, 2025 | Oct 3, 2025 | A | 13,026 | $0.00 | $0 | 13,026 | No | Form 4 |
| Reitan Colleen F | Sep 9, 2025 | Sep 11, 2025 | M | 18,000 | $100.65 | $1,811,700 | 18,775 | Yes | Form 4 |
| Reitan Colleen F | Sep 9, 2025 | Sep 11, 2025 | S | 1,645 | $457.44 | Sale −$752,489 | 17,130 | Yes | Form 4 |
| Reitan Colleen F | Sep 9, 2025 | Sep 11, 2025 | S | 1,888 | $458.86 | Sale −$866,328 | 15,242 | Yes | Form 4 |
| Reitan Colleen F | Sep 9, 2025 | Sep 11, 2025 | S | 1,403 | $459.73 | Sale −$645,001 | 13,839 | Yes | Form 4 |
| Reitan Colleen F | Sep 9, 2025 | Sep 11, 2025 | S | 473 | $460.71 | Sale −$217,916 | 13,366 | Yes | Form 4 |
| Reitan Colleen F | Sep 9, 2025 | Sep 11, 2025 | S | 2,290 | $461.92 | Sale −$1,057,797 | 11,076 | Yes | Form 4 |
| Reitan Colleen F | Sep 9, 2025 | Sep 11, 2025 | S | 1,652 | $463.00 | Sale −$764,876 | 9,424 | Yes | Form 4 |
| Reitan Colleen F | Sep 9, 2025 | Sep 11, 2025 | S | 799 | $464.36 | Sale −$371,024 | 8,625 | Yes | Form 4 |
| Reitan Colleen F | Sep 9, 2025 | Sep 11, 2025 | S | 222 | $471.25 | Sale −$104,618 | 8,403 | Yes | Form 4 |
| Reitan Colleen F | Sep 9, 2025 | Sep 11, 2025 | S | 823 | $472.82 | Sale −$389,131 | 7,580 | Yes | Form 4 |
| Reitan Colleen F | Sep 9, 2025 | Sep 11, 2025 | S | 838 | $474.22 | Sale −$397,396 | 6,742 | Yes | Form 4 |
| Reitan Colleen F | Sep 9, 2025 | Sep 11, 2025 | S | 951 | $474.85 | Sale −$451,582 | 5,791 | Yes | Form 4 |
| Reitan Colleen F | Sep 9, 2025 | Sep 11, 2025 | S | 972 | $476.31 | Sale −$462,973 | 4,819 | Yes | Form 4 |
| Reitan Colleen F | Sep 9, 2025 | Sep 11, 2025 | S | 1,183 | $477.47 | Sale −$564,847 | 3,636 | Yes | Form 4 |
| Reitan Colleen F | Sep 9, 2025 | Sep 11, 2025 | S | 1,450 | $478.67 | Sale −$694,072 | 2,186 | Yes | Form 4 |
| Reitan Colleen F | Sep 9, 2025 | Sep 11, 2025 | S | 1,386 | $479.55 | Sale −$664,656 | 800 | Yes | Form 4 |
| Reitan Colleen F | Sep 9, 2025 | Sep 11, 2025 | S | 25 | $480.98 | Sale −$12,025 | 775 | Yes | Form 4 |
| Reitan Colleen F | Sep 9, 2025 | Sep 11, 2025 | M · derivative | 18,000 | $100.65 | $1,811,700 | not reported | Yes | Form 4 |
| Tanguler TolgaEVP, Chief Commercial Officer | Aug 29, 2025 | Sep 2, 2025 | S | 195 | $445.53 | Sale −$86,878 | 29,271 | Yes | Form 4 |
| Tanguler TolgaEVP, Chief Commercial Officer | Aug 29, 2025 | Sep 2, 2025 | S | 899 | $446.98 | Sale −$401,835 | 28,372 | Yes | Form 4 |
| Tanguler TolgaEVP, Chief Commercial Officer | Aug 29, 2025 | Sep 2, 2025 | S | 1,289 | $448.05 | Sale −$577,536 | 27,083 | Yes | Form 4 |
| Tanguler TolgaEVP, Chief Commercial Officer | Aug 29, 2025 | Sep 2, 2025 | S | 681 | $449.54 | Sale −$306,137 | 26,402 | Yes | Form 4 |
| Tanguler TolgaEVP, Chief Commercial Officer | Aug 29, 2025 | Sep 2, 2025 | S | 266 | $451.52 | Sale −$120,104 | 26,136 | Yes | Form 4 |
| Tanguler TolgaEVP, Chief Commercial Officer | Aug 29, 2025 | Sep 2, 2025 | S | 144 | $452.49 | Sale −$65,159 | 25,992 | Yes | Form 4 |
| Garg PushkalEVP Chief R&D | Aug 19, 2025 | Aug 19, 2025 | S | 276 | $455.41 | Sale −$125,693 | 21,400 | Yes | Form 4 |
| Garg PushkalEVP Chief R&D | Aug 19, 2025 | Aug 19, 2025 | S | 338 | $457.26 | Sale −$154,554 | 21,062 | Yes | Form 4 |
| Garg PushkalEVP Chief R&D | Aug 19, 2025 | Aug 19, 2025 | S | 231 | $458.27 | Sale −$105,860 | 20,831 | Yes | Form 4 |
| Garg PushkalEVP Chief R&D | Aug 19, 2025 | Aug 19, 2025 | S | 260 | $459.59 | Sale −$119,493 | 20,571 | Yes | Form 4 |
| Garg PushkalEVP Chief R&D | Aug 19, 2025 | Aug 19, 2025 | S | 305 | $461.01 | Sale −$140,608 | 20,266 | Yes | Form 4 |
| Garg PushkalEVP Chief R&D | Aug 19, 2025 | Aug 19, 2025 | S | 45 | $461.74 | Sale −$20,778 | 20,221 | Yes | Form 4 |
| Bonney Michael W | Aug 18, 2025 | Aug 19, 2025 | M | 11,250 | $70.20 | $789,750 | 28,054 | Yes | Form 4 |
| Bonney Michael W | Aug 18, 2025 | Aug 19, 2025 | S | 11,250 | $450.00 | Sale −$5,062,500 | 16,804 | Yes | Form 4 |
| Bonney Michael W | Aug 18, 2025 | Aug 19, 2025 | M · derivative | 11,250 | $70.20 | $789,750 | not reported | Yes | Form 4 |
| Fitzgerald Kevin JosephCSO & EVP, Head of Research | Aug 18, 2025 | Aug 19, 2025 | S | 39 | $447.98 | Sale −$17,471 | 24,076 | No | Form 4 |
| Fitzgerald Kevin JosephCSO & EVP, Head of Research | Aug 18, 2025 | Aug 19, 2025 | S | 90 | $449.92 | Sale −$40,493 | 23,986 | No | Form 4 |
| Fitzgerald Kevin JosephCSO & EVP, Head of Research | Aug 18, 2025 | Aug 19, 2025 | S | 39 | $450.92 | Sale −$17,586 | 23,947 | No | Form 4 |
| Fitzgerald Kevin JosephCSO & EVP, Head of Research | Aug 18, 2025 | Aug 19, 2025 | S | 103 | $451.99 | Sale −$46,555 | 23,844 | No | Form 4 |
| Fitzgerald Kevin JosephCSO & EVP, Head of Research | Aug 18, 2025 | Aug 19, 2025 | S | 329 | $452.96 | Sale −$149,024 | 23,515 | No | Form 4 |
| Fitzgerald Kevin JosephCSO & EVP, Head of Research | Aug 18, 2025 | Aug 19, 2025 | S | 543 | $454.04 | Sale −$246,544 | 22,972 | No | Form 4 |
| Fitzgerald Kevin JosephCSO & EVP, Head of Research | Aug 18, 2025 | Aug 19, 2025 | S | 241 | $454.84 | Sale −$109,616 | 22,731 | No | Form 4 |
| Fitzgerald Kevin JosephCSO & EVP, Head of Research | Aug 18, 2025 | Aug 19, 2025 | S | 12 | $455.82 | Sale −$5,470 | 22,719 | No | Form 4 |
| Greenstreet YvonneChief Executive Officer | Aug 18, 2025 | Aug 19, 2025 | S | 194 | $447.98 | Sale −$86,908 | 63,006 | No | Form 4 |
| Greenstreet YvonneChief Executive Officer | Aug 18, 2025 | Aug 19, 2025 | S | 450 | $449.92 | Sale −$202,464 | 62,556 | No | Form 4 |
| Greenstreet YvonneChief Executive Officer | Aug 18, 2025 | Aug 19, 2025 | S | 195 | $450.92 | Sale −$87,929 | 62,361 | No | Form 4 |
| Greenstreet YvonneChief Executive Officer | Aug 18, 2025 | Aug 19, 2025 | S | 514 | $451.99 | Sale −$232,323 | 61,847 | No | Form 4 |
| Greenstreet YvonneChief Executive Officer | Aug 18, 2025 | Aug 19, 2025 | S | 1,646 | $452.96 | Sale −$745,572 | 60,201 | No | Form 4 |
| Greenstreet YvonneChief Executive Officer | Aug 18, 2025 | Aug 19, 2025 | S | 2,716 | $454.04 | Sale −$1,233,173 | 57,485 | No | Form 4 |
| Greenstreet YvonneChief Executive Officer | Aug 18, 2025 | Aug 19, 2025 | S | 1,204 | $454.84 | Sale −$547,627 | 56,281 | No | Form 4 |
| Greenstreet YvonneChief Executive Officer | Aug 18, 2025 | Aug 19, 2025 | S | 60 | $455.82 | Sale −$27,349 | 56,221 | No | Form 4 |
| Poulton Jeffrey V.EVP, Chief Financial Officer | Aug 18, 2025 | Aug 19, 2025 | S | 63 | $447.98 | Sale −$28,223 | 52,332 | No | Form 4 |
| Poulton Jeffrey V.EVP, Chief Financial Officer | Aug 18, 2025 | Aug 19, 2025 | S | 147 | $449.92 | Sale −$66,138 | 52,185 | No | Form 4 |
| Poulton Jeffrey V.EVP, Chief Financial Officer | Aug 18, 2025 | Aug 19, 2025 | S | 63 | $450.92 | Sale −$28,408 | 52,122 | No | Form 4 |
| Poulton Jeffrey V.EVP, Chief Financial Officer | Aug 18, 2025 | Aug 19, 2025 | S | 168 | $451.99 | Sale −$75,934 | 51,954 | No | Form 4 |
| Poulton Jeffrey V.EVP, Chief Financial Officer | Aug 18, 2025 | Aug 19, 2025 | S | 536 | $452.96 | Sale −$242,787 | 51,418 | No | Form 4 |
| Poulton Jeffrey V.EVP, Chief Financial Officer | Aug 18, 2025 | Aug 19, 2025 | S | 886 | $454.04 | Sale −$402,279 | 50,532 | No | Form 4 |
| Poulton Jeffrey V.EVP, Chief Financial Officer | Aug 18, 2025 | Aug 19, 2025 | S | 392 | $454.84 | Sale −$178,297 | 50,140 | No | Form 4 |
| Poulton Jeffrey V.EVP, Chief Financial Officer | Aug 18, 2025 | Aug 19, 2025 | S | 19 | $455.82 | Sale −$8,661 | 50,121 | No | Form 4 |
| Tanguler TolgaEVP, Chief Commercial Officer | Aug 18, 2025 | Aug 19, 2025 | S | 39 | $447.98 | Sale −$17,471 | 30,823 | No | Form 4 |
| Tanguler TolgaEVP, Chief Commercial Officer | Aug 18, 2025 | Aug 19, 2025 | S | 90 | $449.92 | Sale −$40,493 | 30,733 | No | Form 4 |
| Tanguler TolgaEVP, Chief Commercial Officer | Aug 18, 2025 | Aug 19, 2025 | S | 39 | $450.92 | Sale −$17,586 | 30,694 | No | Form 4 |
| Tanguler TolgaEVP, Chief Commercial Officer | Aug 18, 2025 | Aug 19, 2025 | S | 103 | $451.99 | Sale −$46,555 | 30,591 | No | Form 4 |
| Tanguler TolgaEVP, Chief Commercial Officer | Aug 18, 2025 | Aug 19, 2025 | S | 329 | $452.96 | Sale −$149,024 | 30,262 | No | Form 4 |
| Tanguler TolgaEVP, Chief Commercial Officer | Aug 18, 2025 | Aug 19, 2025 | S | 543 | $454.04 | Sale −$246,544 | 29,719 | No | Form 4 |
| Tanguler TolgaEVP, Chief Commercial Officer | Aug 18, 2025 | Aug 19, 2025 | S | 241 | $454.84 | Sale −$109,616 | 29,478 | No | Form 4 |
| Tanguler TolgaEVP, Chief Commercial Officer | Aug 18, 2025 | Aug 19, 2025 | S | 12 | $455.82 | Sale −$5,470 | 29,466 | No | Form 4 |
| Garg PushkalEVP Chief R&D | Aug 18, 2025 | Aug 19, 2025 | S | 39 | $447.98 | Sale −$17,471 | 23,033 | Yes | Form 4 |
| Garg PushkalEVP Chief R&D | Aug 18, 2025 | Aug 19, 2025 | S | 90 | $449.92 | Sale −$40,493 | 22,943 | Yes | Form 4 |
| Garg PushkalEVP Chief R&D | Aug 18, 2025 | Aug 19, 2025 | S | 39 | $450.92 | Sale −$17,586 | 22,904 | Yes | Form 4 |
| Garg PushkalEVP Chief R&D | Aug 18, 2025 | Aug 19, 2025 | S | 103 | $451.99 | Sale −$46,555 | 22,801 | Yes | Form 4 |
| Garg PushkalEVP Chief R&D | Aug 18, 2025 | Aug 19, 2025 | S | 329 | $452.96 | Sale −$149,024 | 22,472 | Yes | Form 4 |
| Garg PushkalEVP Chief R&D | Aug 18, 2025 | Aug 19, 2025 | S | 543 | $454.04 | Sale −$246,544 | 21,929 | Yes | Form 4 |
| Garg PushkalEVP Chief R&D | Aug 18, 2025 | Aug 19, 2025 | S | 241 | $454.84 | Sale −$109,616 | 21,688 | Yes | Form 4 |