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AMLXAmylyx Pharmaceuticals, Inc.

Market cap
$3.41B
as of 2026-10-23
Latest close
$27.20
as of 2026-10-23
Sector
Healthcare
as of 2026-10-24
Industry
Drug Manufacturers - Specialty & Generic
as of 2026-10-24

Cluster

No cluster in the last 90 days under the default rule (14d · ≥2 insiders · all roles).

Form 4 historysince 2023-11-02

Dashed line = amended filing (Form 4/A)

InsiderTradedFiledTypeSharesPriceValueOwned after10b5-1 planFiling
Milne George M JrOct 5Oct 7S30,000$27.70Sale −$830,904782,881YesForm 4
Klee Justin B.Co-Chief Executive OfficerSep 10Sep 14S29,025$32.13Sale −$932,5733,614,495NoForm 4
Klee Justin B.Co-Chief Executive OfficerSep 10Sep 14S1,439$33.16Sale −$47,7173,613,056NoForm 4
Cohen Joshua BCo-Chief Executive OfficerSep 10Sep 14S29,545$32.16Sale −$950,1673,614,042NoForm 4
Cohen Joshua BCo-Chief Executive OfficerSep 10Sep 14S919$33.15Sale −$30,4653,613,123NoForm 4
Mazzariello GinaChief Legal OfficerSep 10Sep 14S9,525$32.46Sale −$309,182190,849NoForm 4
Mazzariello GinaChief Legal OfficerSep 10Sep 14S11$33.34Sale −$367190,838NoForm 4
Frates James MChief Financial OfficerSep 10Sep 14S9,768$32.27Sale −$315,213234,667NoForm 4
Frates James MChief Financial OfficerSep 10Sep 14S1,042$33.23Sale −$34,626233,625NoForm 4
Bedrosian Camille LChief Medical OfficerSep 10Sep 14S7,947$32.21Sale −$255,973280,145NoForm 4
Bedrosian Camille LChief Medical OfficerSep 10Sep 14S2,081$33.09Sale −$68,860278,064NoForm 4
Firestone KarenAug 31Sep 2M25,000$1.76$44,00091,900NoForm 4
Firestone KarenAug 31Sep 2M25,000$5.05$126,250116,900NoForm 4
Firestone KarenAug 31Sep 2M · derivative25,000$1.76$44,000not reportedNoForm 4
Firestone KarenAug 31Sep 2M · derivative25,000$5.05$126,250not reportedNoForm 4
Cohen Joshua BCo-Chief Executive OfficerAug 18Aug 20A60,039$0.00$03,643,587NoForm 4
Bedrosian Camille LChief Medical OfficerAug 18Aug 20A22,807$0.00$0288,092NoForm 4
Mazzariello GinaChief Legal OfficerAug 18Aug 20A21,284$0.00$0200,374NoForm 4
Klee Justin B.Co-Chief Executive OfficerAug 18Aug 20A60,039$0.00$03,643,520NoForm 4
Frates James MChief Financial OfficerAug 18Aug 20A22,807$0.00$0244,435NoForm 4
Mazzariello GinaChief Legal OfficerJul 10Jul 13S15,000$17.61Sale −$264,150179,090YesForm 4
Mazzariello GinaChief Legal OfficerJul 9Jul 13S15,000$18.32Sale −$274,800194,090YesForm 4
Fonteyne Paul R.Jun 4Jun 8A · derivative24,372$14.31$348,76324,372NoForm 4
Milne George M JrJun 4Jun 8A · derivative24,372$14.31$348,76324,372NoForm 4
Quimi DaphneJun 4Jun 8A · derivative24,372$14.31$348,76324,372NoForm 4
Firestone KarenJun 4Jun 8A · derivative24,372$14.31$348,76324,372NoForm 4
Zeiher Bernhardt GJun 4Jun 8A · derivative24,372$14.31$348,76324,372NoForm 4
Firestone KarenMay 21May 26P3,800$13.51Purchase +$51,33866,900NoForm 4
Bedrosian Camille LChief Medical OfficerMar 5Mar 9A95,990$0.00$0265,285NoForm 4
Bedrosian Camille LChief Medical OfficerMar 5Mar 9A · derivative143,985$14.10$2,030,189143,985NoForm 4
Klee Justin B.Co-Chief Executive OfficerMar 5Mar 9A248,865$0.00$03,583,481NoForm 4
Klee Justin B.Co-Chief Executive OfficerMar 5Mar 9A · derivative373,295$14.10$5,263,460373,295NoForm 4
Frates James MChief Financial OfficerMar 5Mar 9A95,990$0.00$0261,628NoForm 4
Frates James MChief Financial OfficerMar 5Mar 9A · derivative143,985$14.10$2,030,189143,985NoForm 4
Mazzariello GinaChief Legal OfficerMar 5Mar 9A74,660$0.00$0209,090NoForm 4
Mazzariello GinaChief Legal OfficerMar 5Mar 9A · derivative111,990$14.10$1,579,059111,990NoForm 4
Cohen Joshua BCo-Chief Executive OfficerMar 5Mar 9A248,865$0.00$03,583,548NoForm 4
Cohen Joshua BCo-Chief Executive OfficerMar 5Mar 9A · derivative373,295$14.10$5,263,460373,295NoForm 4
Mazzariello GinaChief Legal OfficerMar 2Mar 4S6,844$14.52Sale −$99,375134,430NoForm 4
Frates James MChief Financial OfficerMar 2Mar 4S7,909$14.52Sale −$114,839165,638NoForm 4
Bedrosian Camille LChief Medical OfficerMar 2Mar 4S6,461$14.58Sale −$94,201169,295NoForm 4
Cohen Joshua BCo-Chief Executive OfficerMar 2Mar 4S29,282$14.48Sale −$424,0033,334,683NoForm 4
Klee Justin B.Co-Chief Executive OfficerMar 2Mar 4S29,282$14.47Sale −$423,7113,334,616NoForm 4
Mazzariello GinaChief Legal OfficerFeb 23Feb 25S3,419$14.14Sale −$48,345141,274NoForm 4
Klee Justin B.Co-Chief Executive OfficerFeb 2Feb 4S15,500$14.69Sale −$227,6953,363,898NoForm 4
Mazzariello GinaChief Legal OfficerFeb 2Feb 4S3,448$14.65Sale −$50,513144,693NoForm 4
Cohen Joshua BCo-Chief Executive OfficerFeb 2Feb 4S15,500$14.68Sale −$227,5403,363,965NoForm 4
Frates James MChief Financial OfficerFeb 2Feb 4S3,557$14.65Sale −$52,110173,547NoForm 4
Klee Justin B.Co-Chief Executive OfficerJan 16Jan 20M2,847$7.57$21,5523,381,393NoForm 4
Klee Justin B.Co-Chief Executive OfficerJan 16Jan 20S1,995$13.89Sale −$27,7113,379,398NoForm 4
Klee Justin B.Co-Chief Executive OfficerJan 16Jan 20M · derivative2,847$7.57$21,552not reportedNoForm 4
Cohen Joshua BCo-Chief Executive OfficerJan 16Jan 20M2,818$7.57$21,3323,381,439NoForm 4
Cohen Joshua BCo-Chief Executive OfficerJan 16Jan 20S1,974$13.83Sale −$27,3003,379,465NoForm 4
Cohen Joshua BCo-Chief Executive OfficerJan 16Jan 20M · derivative2,818$7.57$21,332not reportedNoForm 4
Klee Justin B.Co-Chief Executive OfficerJan 15Jan 20M197,153$7.57$1,492,4483,514,739NoForm 4
Klee Justin B.Co-Chief Executive OfficerJan 15Jan 20S136,193$13.58Sale −$1,849,5013,378,546NoForm 4
Klee Justin B.Co-Chief Executive OfficerJan 15Jan 20M · derivative197,153$7.57$1,492,4482,847NoForm 4
Cohen Joshua BCo-Chief Executive OfficerJan 15Jan 20M197,182$7.57$1,492,6683,514,814NoForm 4
Cohen Joshua BCo-Chief Executive OfficerJan 15Jan 20S136,193$13.59Sale −$1,850,8633,378,621NoForm 4
Cohen Joshua BCo-Chief Executive OfficerJan 15Jan 20M · derivative197,182$7.57$1,492,6682,818NoForm 4
Milne George M JrJan 12Jan 14G17,780$0.00$0812,881NoForm 4
Klee Justin B.Co-Chief Executive OfficerJan 6Jan 8S7,715$11.09Sale −$85,5593,317,586NoForm 4
Cohen Joshua BCo-Chief Executive OfficerJan 6Jan 8S7,715$11.09Sale −$85,5593,317,632NoForm 4
Frates James MChief Financial OfficerJan 6Jan 8S3,326$11.11Sale −$36,952177,104NoForm 4
Firestone KarenDec 23, 2025Dec 23, 2025P8,100$12.45Purchase +$100,84563,100NoForm 4
Bedrosian Camille LChief Medical OfficerDec 1, 2025Dec 3, 2025S6,580$14.35Sale −$94,423175,756NoForm 4
Bedrosian Camille LChief Medical OfficerSep 30, 2025Oct 2, 2025S12,039$14.58Sale −$175,529182,336NoForm 4
Cohen Joshua BCo-Chief Executive OfficerSep 30, 2025Oct 2, 2025S29,733$14.34Sale −$426,3713,325,547NoForm 4
Cohen Joshua BCo-Chief Executive OfficerSep 30, 2025Oct 2, 2025S200$15.00Sale −$3,0003,325,347NoForm 4
Frates James MChief Financial OfficerSep 30, 2025Oct 2, 2025S10,558$14.65Sale −$154,675280,430NoForm 4
Mazzariello GinaChief Legal OfficerSep 30, 2025Oct 2, 2025S8,828$14.58Sale −$128,712148,141NoForm 4
Klee Justin B.Co-Chief Executive OfficerSep 30, 2025Oct 2, 2025S29,775$14.37Sale −$427,8673,325,501NoForm 4
Klee Justin B.Co-Chief Executive OfficerSep 30, 2025Oct 2, 2025S200$15.01Sale −$3,0023,325,301NoForm 4
Mazzariello GinaChief Legal OfficerAug 13, 2025Aug 14, 2025S15,000$8.34Sale −$125,100156,969YesForm 4
Mazzariello GinaChief Legal OfficerAug 12, 2025Aug 14, 2025S15,000$8.07Sale −$121,050171,969YesForm 4
Zeiher Bernhardt GJun 5, 2025Jun 9, 2025A · derivative25,000$5.05$126,25025,000NoForm 4
Milne George M JrJun 5, 2025Jun 9, 2025A · derivative25,000$5.05$126,25025,000NoForm 4
Quimi DaphneJun 5, 2025Jun 9, 2025A · derivative25,000$5.05$126,25025,000NoForm 4
Firestone KarenJun 5, 2025Jun 9, 2025A · derivative25,000$5.05$126,25025,000NoForm 4
Fonteyne Paul R.Jun 5, 2025Jun 9, 2025A · derivative25,000$5.05$126,25025,000NoForm 4
Mazzariello GinaChief Legal OfficerMay 22, 2025May 27, 2025G1,000$0.00$0186,969NoForm 4
Klee Justin B.Co-Chief Executive OfficerMar 31, 2025Apr 2, 2025S21,490$3.46Sale −$74,3553,355,276NoForm 4
Cohen Joshua BCo-Chief Executive OfficerMar 31, 2025Apr 2, 2025S21,490$3.47Sale −$74,5703,355,280NoForm 4
Mazzariello GinaChief Legal OfficerMar 31, 2025Apr 2, 2025S9,192$3.48Sale −$31,988187,969NoForm 4
Bedrosian Camille LChief Medical OfficerMar 31, 2025Apr 2, 2025S12,425$3.47Sale −$43,115194,375NoForm 4
Frates James MChief Financial OfficerMar 31, 2025Apr 2, 2025S10,896$3.47Sale −$37,809290,988NoForm 4
Zeiher Bernhardt GMar 20, 2025Mar 24, 2025P10,000$3.70Purchase +$37,00010,000NoForm 4
Frates James MChief Financial OfficerMar 6, 2025Mar 10, 2025A68,420$0.00$0301,884NoForm 4
Frates James MChief Financial OfficerMar 6, 2025Mar 10, 2025A · derivative102,630$3.61$370,494102,630NoForm 4
Cohen Joshua BCo-Chief Executive OfficerMar 6, 2025Mar 10, 2025A180,118$0.00$03,376,770NoForm 4
Cohen Joshua BCo-Chief Executive OfficerMar 6, 2025Mar 10, 2025A · derivative270,177$3.61$975,339270,177NoForm 4
Klee Justin B.Co-Chief Executive OfficerMar 6, 2025Mar 10, 2025A180,118$0.00$03,376,766NoForm 4
Klee Justin B.Co-Chief Executive OfficerMar 6, 2025Mar 10, 2025A · derivative270,177$3.61$975,339270,177NoForm 4
Bedrosian Camille LChief Medical OfficerMar 6, 2025Mar 10, 2025A68,420$0.00$0206,800NoForm 4
Bedrosian Camille LChief Medical OfficerMar 6, 2025Mar 10, 2025A · derivative102,630$3.61$370,494102,630NoForm 4
Mazzariello GinaChief Legal OfficerMar 6, 2025Mar 10, 2025A63,851$0.00$0197,161NoForm 4
Mazzariello GinaChief Legal OfficerMar 6, 2025Mar 10, 2025A · derivative95,777$3.61$345,75595,777NoForm 4
Mazzariello GinaChief Legal OfficerMar 3, 2025Mar 5, 2025S1,611$3.12Sale −$5,026133,310NoForm 4
Cohen Joshua BCo-Chief Executive OfficerMar 3, 2025Mar 5, 2025S4,595$3.17Sale −$14,5663,196,652NoForm 4
Klee Justin B.Co-Chief Executive OfficerMar 3, 2025Mar 5, 2025S4,595$3.15Sale −$14,4743,196,648NoForm 4
Mazzariello GinaChief Legal OfficerFeb 24, 2025Feb 26, 2025S4,169$3.15Sale −$13,132134,921NoForm 4
Klee Justin B.Co-Chief Executive OfficerFeb 5, 2025Feb 6, 2025M36,310$1.57$57,0073,201,243NoForm 4
Klee Justin B.Co-Chief Executive OfficerFeb 5, 2025Feb 6, 2025M · derivative36,310$1.57$57,007not reportedNoForm 4
Klee Justin B.Co-Chief Executive OfficerFeb 3, 2025Feb 5, 2025S11,855$3.47Sale −$41,1373,164,933NoForm 4
Cohen Joshua BCo-Chief Executive OfficerFeb 3, 2025Feb 5, 2025S11,851$3.47Sale −$41,1233,201,247NoForm 4
Mazzariello GinaChief Legal OfficerFeb 3, 2025Feb 5, 2025S3,678$3.49Sale −$12,836139,090NoForm 4
Milne George M JrJan 24, 2025Jan 28, 2025G27,910$0.00$0830,661NoForm 4
Cohen Joshua BCo-Chief Executive OfficerJan 6, 2025Jan 8, 2025S7,471$4.05Sale −$30,2583,213,098NoForm 4
Klee Justin B.Co-Chief Executive OfficerJan 6, 2025Jan 8, 2025S7,471$4.04Sale −$30,1833,176,788NoForm 4
Bedrosian Camille LChief Medical OfficerDec 2, 2024Dec 3, 2024S5,421$5.54Sale −$30,032138,380NoForm 4
Klee Justin B.Co-Chief Executive OfficerNov 4, 2024Nov 6, 2024M63,690$1.57$99,9933,184,259NoForm 4
Klee Justin B.Co-Chief Executive OfficerNov 4, 2024Nov 6, 2024M · derivative63,690$1.57$99,99336,310NoForm 4
Mazzariello GinaChief Legal OfficerSep 30, 2024Oct 2, 2024S8,709$3.20Sale −$27,869142,768NoForm 4
Bedrosian Camille LChief Medical OfficerSep 30, 2024Oct 2, 2024S11,442$3.20Sale −$36,614143,801NoForm 4
Cohen Joshua BCo-Chief Executive OfficerSep 30, 2024Oct 2, 2024S18,589$3.20Sale −$59,4853,220,569NoForm 4
Klee Justin B.Co-Chief Executive OfficerSep 30, 2024Oct 2, 2024S18,589$3.20Sale −$59,4853,120,569NoForm 4
Cohen Joshua BCo-Chief Executive OfficerSep 23, 2024Sep 25, 2024M1,857$1.57$2,9153,239,158NoForm 4
Cohen Joshua BCo-Chief Executive OfficerSep 23, 2024Sep 25, 2024M · derivative1,857$1.57$2,915not reportedNoForm 4
Frates James MChief Financial OfficerSep 12, 2024Sep 16, 2024P40,000$2.53Purchase +$101,200233,464NoForm 4
Cohen Joshua BCo-Chief Executive OfficerSep 12, 2024Sep 16, 2024M34,449$1.57$54,0853,237,301NoForm 4
Cohen Joshua BCo-Chief Executive OfficerSep 12, 2024Sep 16, 2024M · derivative34,449$1.57$54,0851,857NoForm 4
Firestone KarenSep 5, 2024Sep 9, 2024P50,000$2.13Purchase +$106,50055,000NoForm 4
Milne George M JrSep 3, 2024Sep 5, 2024P100,000$2.20Purchase +$220,000858,571NoForm 4
Frates James MChief Financial OfficerAug 23, 2023Sep 5, 20244/AM18,165$6.88$124,97573,841NoForm 4/A
Frates James MChief Financial OfficerAug 23, 2023Sep 5, 20244/AM · derivative18,165$6.88$124,975363,835NoForm 4/A
Quimi DaphneJun 6, 2024Jun 7, 2024A · derivative25,000$1.76$44,00025,000NoForm 4
Milne George M JrJun 6, 2024Jun 7, 2024A · derivative25,000$1.76$44,00025,000NoForm 4
Zeiher Bernhardt GJun 6, 2024Jun 7, 2024A · derivative5,753$1.76$10,1255,753NoForm 4
Firestone KarenJun 6, 2024Jun 7, 2024A · derivative25,000$1.76$44,00025,000NoForm 4
Fonteyne Paul R.Jun 6, 2024Jun 7, 2024A · derivative25,000$1.76$44,00025,000NoForm 4
Mazzariello GinaChief Legal OfficerMay 15, 2024May 16, 2024S10,455$1.88Sale −$19,655151,477YesForm 4
Quimi DaphneMay 15, 2024May 16, 2024P2,250$1.89Purchase +$4,2535,000NoForm 4
Quimi DaphneMay 14, 2024May 16, 2024P2,750$1.89Purchase +$5,1982,750NoForm 4
Bedrosian Camille LChief Medical OfficerApr 16, 2024Apr 18, 2024A96,910$0.00$0155,243NoForm 4
Bedrosian Camille LChief Medical OfficerApr 16, 2024Apr 18, 2024A · derivative120,000$2.01$241,200120,000NoForm 4
Klee Justin B.Co-Chief Executive OfficerApr 16, 2024Apr 18, 2024A179,850$0.00$03,139,158NoForm 4
Klee Justin B.Co-Chief Executive OfficerApr 16, 2024Apr 18, 2024A · derivative380,000$2.01$763,800380,000NoForm 4
Mazzariello GinaChief Legal OfficerApr 16, 2024Apr 18, 2024A80,560$0.00$0161,932NoForm 4
Mazzariello GinaChief Legal OfficerApr 16, 2024Apr 18, 2024A · derivative110,000$2.01$221,100110,000NoForm 4
Cohen Joshua BCo-Chief Executive OfficerApr 16, 2024Apr 18, 2024A179,850$0.00$03,202,852NoForm 4
Cohen Joshua BCo-Chief Executive OfficerApr 16, 2024Apr 18, 2024A · derivative380,000$2.01$763,800380,000NoForm 4
Frates James MChief Financial OfficerApr 16, 2024Apr 18, 2024A91,180$0.00$0225,964NoForm 4
Frates James MChief Financial OfficerApr 16, 2024Apr 18, 2024A · derivative120,000$2.01$241,200120,000NoForm 4
Zeiher Bernhardt GMar 14, 2024Mar 15, 2024A · derivative50,000$3.17$158,50050,000NoForm 4
Frates James MChief Financial OfficerMar 5, 2024Mar 7, 2024S1,792$18.73Sale −$33,564134,784NoForm 4
Mazzariello GinaChief Legal OfficerMar 5, 2024Mar 7, 2024S1,540$18.73Sale −$28,84481,372NoForm 4
Klee Justin B.Co-Chief Executive OfficerMar 5, 2024Mar 7, 2024S4,135$18.73Sale −$77,4492,959,308NoForm 4
Cohen Joshua BCo-Chief Executive OfficerMar 5, 2024Mar 7, 2024S4,135$18.73Sale −$77,4493,023,002NoForm 4
Mazzariello GinaChief Legal OfficerFeb 26, 2024Feb 28, 2024A36,667$0.00$082,912NoForm 4
Mazzariello GinaChief Legal OfficerFeb 26, 2024Feb 28, 2024A · derivative55,000$17.56$965,80055,000NoForm 4
Klee Justin B.Co-Chief Executive OfficerFeb 26, 2024Feb 28, 2024A126,667$0.00$02,963,443NoForm 4
Klee Justin B.Co-Chief Executive OfficerFeb 26, 2024Feb 28, 2024A · derivative190,000$17.56$3,336,400190,000NoForm 4
Cohen Joshua BCo-Chief Executive OfficerFeb 26, 2024Feb 28, 2024A126,667$0.00$03,027,137NoForm 4
Cohen Joshua BCo-Chief Executive OfficerFeb 26, 2024Feb 28, 2024A · derivative190,000$17.56$3,336,400190,000NoForm 4
Frates James MChief Financial OfficerFeb 26, 2024Feb 28, 2024A40,000$0.00$0152,035NoForm 4
Frates James MChief Financial OfficerFeb 26, 2024Feb 28, 2024A · derivative60,000$17.56$1,053,60060,000NoForm 4
Mazzariello GinaChief Legal OfficerFeb 23, 2024Feb 27, 2024S2,838$18.76Sale −$53,24146,245NoForm 4
Milne George M JrJan 25, 2024Jan 29, 2024G9,100$0.00$0758,571NoForm 4
Milne George M JrJan 16, 2024Jan 18, 2024G94,350$0.00$0767,671NoForm 4
Yeramian Patrick DChief Medical OfficerJan 9, 2024Jan 11, 2024S2,812$16.33Sale −$45,920205,605NoForm 4
Cohen Joshua BCo-Chief Executive OfficerJan 9, 2024Jan 11, 2024S5,841$16.33Sale −$95,3842,900,470NoForm 4
Frates James MChief Financial OfficerJan 9, 2024Jan 11, 2024S2,716$16.33Sale −$44,352112,035NoForm 4
Klee Justin B.Co-Chief Executive OfficerJan 9, 2024Jan 11, 2024S5,841$16.33Sale −$95,3842,836,776NoForm 4
Olinger MargaretChief Commercial OfficerDec 27, 2023Dec 29, 2023M25,000$0.37$9,250276,108NoForm 4
Olinger MargaretChief Commercial OfficerDec 27, 2023Dec 29, 2023M · derivative25,000$0.37$9,25044,577NoForm 4
Firestone KarenDec 15, 2023Dec 19, 2023P4,000$14.97Purchase +$59,8805,000NoForm 4
Bedrosian Camille LChief Medical OfficerNov 27, 2023Nov 29, 2023A58,333$0.00$058,333NoForm 4
Bedrosian Camille LChief Medical OfficerNov 27, 2023Nov 29, 2023A · derivative162,500$12.93$2,101,125162,500NoForm 4
Cohen Joshua BCo-Chief Executive OfficerNov 16, 2023Nov 20, 2023M63,694$1.57$100,0002,906,311NoForm 4
Cohen Joshua BCo-Chief Executive OfficerNov 16, 2023Nov 20, 2023M · derivative63,694$1.57$100,00036,306NoForm 4
Frates James MChief Financial OfficerOct 31, 2023Nov 2, 2023G11,072$0.00$011,072NoForm 4