APGEApogee Therapeutics, Inc.
- Market cap
- not reported
- Latest close
- not reported
- Sector
- Healthcare
- as of 2026-10-24
- Industry
- Biotechnology
- as of 2026-10-24
Values marked — are missing or out of date.
Cluster
No cluster in the last 90 days under the default rule (14d · ≥2 insiders · all roles).
Form 4 historysince 2023-12-20
| Insider | Traded | Filed | Type | Shares | Price | Value | Owned after | 10b5-1 plan | Filing |
|---|---|---|---|---|---|---|---|---|---|
| Fairmount Funds Management LLC | Sep 3 | Sep 3 | D | 340,855 | not reported | not reported | not reported | No | Form 4 |
| Fairmount Funds Management LLC | Sep 3 | Sep 3 | D | 51,166 | not reported | not reported | not reported | No | Form 4 |
| Fairmount Funds Management LLC | Sep 3 | Sep 3 | D | 51,166 | not reported | not reported | not reported | No | Form 4 |
| Fairmount Funds Management LLC | Sep 3 | Sep 3 | D · derivative | 6,743,321 | not reported | not reported | not reported | No | Form 4 |
| Fairmount Funds Management LLC | Sep 3 | Sep 3 | D · derivative | 47,758 | $17.00 | $811,886 | not reported | No | Form 4 |
| Fairmount Funds Management LLC | Sep 3 | Sep 3 | D · derivative | 10,370 | $43.85 | $454,725 | not reported | No | Form 4 |
| Fairmount Funds Management LLC | Sep 3 | Sep 3 | D · derivative | 14,461 | $41.66 | $602,445 | not reported | No | Form 4 |
| Fairmount Funds Management LLC | Sep 3 | Sep 3 | D · derivative | 7,657 | $85.00 | $650,845 | not reported | No | Form 4 |
| Shah Nimish P | Sep 3 | Sep 3 | D | 1,750,000 | $135.11 | $236,442,500 | not reported | No | Form 4 |
| Shah Nimish P | Sep 3 | Sep 3 | D · derivative | 6,743,321 | $135.11 | $911,090,100 | not reported | No | Form 4 |
| Shah Nimish P | Sep 3 | Sep 3 | D · derivative | 47,758 | $17.00 | $811,886 | not reported | No | Form 4 |
| Shah Nimish P | Sep 3 | Sep 3 | D · derivative | 10,370 | $43.85 | $454,725 | not reported | No | Form 4 |
| Shah Nimish P | Sep 3 | Sep 3 | D · derivative | 14,461 | $41.66 | $602,445 | not reported | No | Form 4 |
| Shah Nimish P | Sep 3 | Sep 3 | D · derivative | 7,657 | $85.00 | $650,845 | not reported | No | Form 4 |
| Shah Nimish P | Sep 3 | Sep 3 | D · derivative | 365,853 | not reported | not reported | not reported | No | Form 4 |
| Henderson Michael ThomasChief Executive Officer | Sep 3 | Sep 3 | D | 920,941 | not reported | not reported | not reported | No | Form 4 |
| Henderson Michael ThomasChief Executive Officer | Sep 3 | Sep 3 | D · derivative | 387,012 | $22.86 | $8,847,094 | not reported | No | Form 4 |
| Henderson Michael ThomasChief Executive Officer | Sep 3 | Sep 3 | D · derivative | 357,036 | $49.07 | $17,519,757 | not reported | No | Form 4 |
| Henderson Michael ThomasChief Executive Officer | Sep 3 | Sep 3 | D · derivative | 253,016 | $75.78 | $19,173,552 | not reported | No | Form 4 |
| Bollinger Lisa | Sep 3 | Sep 3 | D · derivative | 18,550 | $47.86 | $887,803 | not reported | No | Form 4 |
| Bollinger Lisa | Sep 3 | Sep 3 | D · derivative | 8,112 | $43.85 | $355,711 | not reported | No | Form 4 |
| Bollinger Lisa | Sep 3 | Sep 3 | D · derivative | 14,461 | $41.66 | $602,445 | not reported | No | Form 4 |
| Bollinger Lisa | Sep 3 | Sep 3 | D · derivative | 7,657 | $85.00 | $650,845 | not reported | No | Form 4 |
| Henderson JaneChief Financial Officer | Sep 3 | Sep 3 | D | 158,371 | not reported | not reported | not reported | No | Form 4 |
| Henderson JaneChief Financial Officer | Sep 3 | Sep 3 | D · derivative | 175,345 | $22.86 | $4,008,387 | not reported | No | Form 4 |
| Henderson JaneChief Financial Officer | Sep 3 | Sep 3 | D · derivative | 124,962 | $49.07 | $6,131,885 | not reported | No | Form 4 |
| Henderson JaneChief Financial Officer | Sep 3 | Sep 3 | D · derivative | 83,690 | $75.78 | $6,342,028 | not reported | No | Form 4 |
| Fox Jennifer A. | Sep 3 | Sep 3 | D | 34,824 | not reported | not reported | not reported | No | Form 4 |
| Fox Jennifer A. | Sep 3 | Sep 3 | D · derivative | 10,370 | $43.85 | $454,725 | not reported | No | Form 4 |
| Fox Jennifer A. | Sep 3 | Sep 3 | D · derivative | 14,461 | $41.66 | $602,445 | not reported | No | Form 4 |
| Fox Jennifer A. | Sep 3 | Sep 3 | D · derivative | 7,657 | $85.00 | $650,845 | not reported | No | Form 4 |
| Dambkowski CarlChief Medical Officer | Sep 3 | Sep 3 | D | 167,123 | not reported | not reported | not reported | No | Form 4 |
| Dambkowski CarlChief Medical Officer | Sep 3 | Sep 3 | D · derivative | 110,665 | $22.86 | $2,529,802 | not reported | No | Form 4 |
| Dambkowski CarlChief Medical Officer | Sep 3 | Sep 3 | D · derivative | 124,962 | $49.07 | $6,131,885 | not reported | No | Form 4 |
| Dambkowski CarlChief Medical Officer | Sep 3 | Sep 3 | D · derivative | 83,690 | $75.78 | $6,342,028 | not reported | No | Form 4 |
| Jones William A Jr | Sep 3 | Sep 3 | D | 34,824 | not reported | not reported | not reported | No | Form 4 |
| Jones William A Jr | Sep 3 | Sep 3 | D · derivative | 10,370 | $43.85 | $454,725 | not reported | No | Form 4 |
| Jones William A Jr | Sep 3 | Sep 3 | D · derivative | 14,461 | $41.66 | $602,445 | not reported | No | Form 4 |
| Jones William A Jr | Sep 3 | Sep 3 | D · derivative | 7,657 | $85.00 | $650,845 | not reported | No | Form 4 |
| McKenna Mark C. | Sep 3 | Sep 3 | D | 20,000 | not reported | not reported | not reported | No | Form 4 |
| McKenna Mark C. | Sep 3 | Sep 3 | D · derivative | 150,000 | $23.60 | $3,540,000 | not reported | No | Form 4 |
| McKenna Mark C. | Sep 3 | Sep 3 | D · derivative | 10,370 | $43.85 | $454,725 | not reported | No | Form 4 |
| McKenna Mark C. | Sep 3 | Sep 3 | D · derivative | 14,461 | $41.66 | $602,445 | not reported | No | Form 4 |
| McKenna Mark C. | Sep 3 | Sep 3 | D · derivative | 7,657 | $85.00 | $650,845 | not reported | No | Form 4 |
| Dambkowski CarlChief Medical Officer | Sep 2 | Sep 3 | D | 1,375 | $135.06 | $185,708 | 167,123 | No | Form 4 |
| Fairmount Healthcare Fund II L.P. | Aug 7 | Aug 11 | M | 31,838 | $17.00 | $541,246 | 330,485 | No | Form 4 |
| Fairmount Healthcare Fund II L.P. | Aug 7 | Aug 11 | M | 10,370 | $43.85 | $454,725 | 340,855 | No | Form 4 |
| Fairmount Healthcare Fund II L.P. | Aug 7 | Aug 11 | M · derivative | 31,838 | $17.00 | $541,246 | not reported | No | Form 4 |
| Fairmount Healthcare Fund II L.P. | Aug 7 | Aug 11 | M · derivative | 10,370 | $43.85 | $454,725 | not reported | No | Form 4 |
| Dambkowski CarlChief Medical Officer | Aug 5 | Aug 7 | M | 4,125 | $22.86 | $94,298 | 173,998 | Yes | Form 4 |
| Dambkowski CarlChief Medical Officer | Aug 5 | Aug 7 | S | 5,500 | $134.17 | Sale −$737,935 | 168,498 | Yes | Form 4 |
| Dambkowski CarlChief Medical Officer | Aug 5 | Aug 7 | M · derivative | 4,125 | $22.86 | $94,298 | 110,665 | Yes | Form 4 |
| Henderson JaneChief Financial Officer | Jul 24 | Jul 24 | G | 15,000 | $0.00 | $0 | 158,371 | No | Form 4 |
| Dambkowski CarlChief Medical Officer | Jul 14 | Jul 16 | G | 8,000 | $0.00 | $0 | 169,873 | No | Form 4 |
| Henderson Michael ThomasChief Executive Officer | Jul 10 | Jul 10 | G | 75,046 | $0.00 | $0 | 920,941 | Yes | Form 4 |
| Henderson Michael ThomasChief Executive Officer | Jul 8 | Jul 10 | S | 20,000 | $133.63 | Sale −$2,672,600 | 995,987 | Yes | Form 4 |
| Dambkowski CarlChief Medical Officer | Jul 1 | Jul 2 | M | 4,125 | $22.86 | $94,298 | 183,373 | Yes | Form 4 |
| Dambkowski CarlChief Medical Officer | Jul 1 | Jul 2 | S | 5,500 | $132.74 | Sale −$730,070 | 177,873 | Yes | Form 4 |
| Dambkowski CarlChief Medical Officer | Jul 1 | Jul 2 | M · derivative | 4,125 | $22.86 | $94,298 | 114,790 | Yes | Form 4 |
| Henderson Michael ThomasChief Executive Officer | Jun 22 | Jun 24 | S | 80,000 | $132.54 | Sale −$10,603,200 | 1,015,987 | Yes | Form 4 |
| Dambkowski CarlChief Medical Officer | Jun 22 | Jun 24 | S | 26,400 | $132.60 | Sale −$3,500,640 | 179,248 | Yes | Form 4 |
| Henderson Michael ThomasChief Executive Officer | Jun 10 | Jun 12 | S | 6,770 | $82.21 | Sale −$556,562 | 1,109,217 | Yes | Form 4 |
| Henderson Michael ThomasChief Executive Officer | Jun 10 | Jun 12 | S | 7,654 | $82.78 | Sale −$633,598 | 1,101,563 | Yes | Form 4 |
| Henderson Michael ThomasChief Executive Officer | Jun 10 | Jun 12 | S | 1,080 | $84.18 | Sale −$90,914 | 1,100,483 | Yes | Form 4 |
| Henderson Michael ThomasChief Executive Officer | Jun 10 | Jun 12 | S | 1,577 | $85.19 | Sale −$134,345 | 1,098,906 | Yes | Form 4 |
| Henderson Michael ThomasChief Executive Officer | Jun 10 | Jun 12 | S | 2,305 | $86.27 | Sale −$198,852 | 1,096,601 | Yes | Form 4 |
| Henderson Michael ThomasChief Executive Officer | Jun 10 | Jun 12 | S | 614 | $86.89 | Sale −$53,350 | 1,095,987 | Yes | Form 4 |
| Bollinger Lisa | Jun 9 | Jun 11 | A · derivative | 7,657 | $85.00 | $650,845 | 7,657 | No | Form 4 |
| Fox Jennifer A. | Jun 9 | Jun 11 | A · derivative | 7,657 | $85.00 | $650,845 | 7,657 | No | Form 4 |
| Jones William A Jr | Jun 9 | Jun 11 | A · derivative | 7,657 | $85.00 | $650,845 | 7,657 | No | Form 4 |
| McKenna Mark C. | Jun 9 | Jun 11 | A · derivative | 7,657 | $85.00 | $650,845 | 7,657 | No | Form 4 |
| Shah Nimish P | Jun 9 | Jun 11 | A · derivative | 7,657 | $85.00 | $650,845 | 7,657 | No | Form 4 |
| Kiselak Tomas | Jun 9 | Jun 11 | A · derivative | 7,657 | $85.00 | $650,845 | 7,657 | No | Form 4 |
| Dambkowski CarlChief Medical Officer | Jun 3 | Jun 5 | M | 4,125 | $22.86 | $94,298 | 211,148 | Yes | Form 4 |
| Dambkowski CarlChief Medical Officer | Jun 3 | Jun 5 | S | 5,500 | $78.71 | Sale −$432,905 | 205,648 | Yes | Form 4 |
| Dambkowski CarlChief Medical Officer | Jun 3 | Jun 5 | M · derivative | 4,125 | $22.86 | $94,298 | 118,915 | Yes | Form 4 |
| Henderson Michael ThomasChief Executive Officer | May 13 | May 15 | S | 18,659 | $82.05 | Sale −$1,530,971 | 1,117,328 | Yes | Form 4 |
| Henderson Michael ThomasChief Executive Officer | May 13 | May 15 | S | 1,341 | $82.58 | Sale −$110,740 | 1,115,987 | Yes | Form 4 |
| Dambkowski CarlChief Medical Officer | May 6 | May 8 | M | 4,125 | $22.86 | $94,298 | 212,523 | Yes | Form 4 |
| Dambkowski CarlChief Medical Officer | May 6 | May 8 | S | 3,700 | $83.92 | Sale −$310,504 | 208,823 | Yes | Form 4 |
| Dambkowski CarlChief Medical Officer | May 6 | May 8 | S | 1,800 | $84.60 | Sale −$152,280 | 207,023 | Yes | Form 4 |
| Dambkowski CarlChief Medical Officer | May 6 | May 8 | M · derivative | 4,125 | $22.86 | $94,298 | 123,040 | Yes | Form 4 |
| Henderson JaneChief Financial Officer | May 1 | May 4 | S | 811 | $81.02 | Sale −$65,707 | 174,560 | Yes | Form 4 |
| Henderson JaneChief Financial Officer | May 1 | May 4 | S | 900 | $82.60 | Sale −$74,340 | 173,660 | Yes | Form 4 |
| Henderson JaneChief Financial Officer | May 1 | May 4 | S | 289 | $83.16 | Sale −$24,033 | 173,371 | Yes | Form 4 |
| Henderson Michael ThomasChief Executive Officer | Apr 16 | Apr 20 | M | 3,000 | $22.86 | $68,580 | 1,135,987 | No | Form 4 |
| Henderson Michael ThomasChief Executive Officer | Apr 16 | Apr 20 | M · derivative | 3,000 | $22.86 | $68,580 | 387,012 | No | Form 4 |
| Henderson JaneChief Financial Officer | Apr 16 | Apr 17 | S | 2,000 | $90.00 | Sale −$180,000 | 175,371 | Yes | Form 4 |
| Henderson Michael ThomasChief Executive Officer | Apr 8 | Apr 10 | S | 17,800 | $82.48 | Sale −$1,468,144 | 1,135,187 | Yes | Form 4 |
| Henderson Michael ThomasChief Executive Officer | Apr 8 | Apr 10 | S | 2,000 | $83.26 | Sale −$166,520 | 1,133,187 | Yes | Form 4 |
| Henderson Michael ThomasChief Executive Officer | Apr 8 | Apr 10 | S | 200 | $85.00 | Sale −$17,000 | 1,132,987 | Yes | Form 4 |
| Henderson JaneChief Financial Officer | Apr 1 | Apr 3 | S | 900 | $84.46 | Sale −$76,014 | 178,471 | Yes | Form 4 |
| Henderson JaneChief Financial Officer | Apr 1 | Apr 3 | S | 1,100 | $85.46 | Sale −$94,006 | 177,371 | Yes | Form 4 |
| Dambkowski CarlChief Medical Officer | Apr 1 | Apr 3 | M | 4,125 | $22.86 | $94,298 | 213,898 | Yes | Form 4 |
| Dambkowski CarlChief Medical Officer | Apr 1 | Apr 3 | S | 2,698 | $84.31 | Sale −$227,468 | 211,200 | Yes | Form 4 |
| Dambkowski CarlChief Medical Officer | Apr 1 | Apr 3 | S | 2,702 | $85.33 | Sale −$230,562 | 208,498 | Yes | Form 4 |
| Dambkowski CarlChief Medical Officer | Apr 1 | Apr 3 | S | 100 | $85.89 | Sale −$8,589 | 208,398 | Yes | Form 4 |
| Dambkowski CarlChief Medical Officer | Apr 1 | Apr 3 | M · derivative | 4,125 | $22.86 | $94,298 | 127,165 | Yes | Form 4 |
| Henderson JaneChief Financial Officer | Mar 25 | Mar 27 | S | 2,000 | $85.00 | Sale −$170,000 | 179,371 | Yes | Form 4 |
| Henderson Michael ThomasChief Executive Officer | Mar 11 | Mar 13 | S | 8,363 | $74.29 | Sale −$621,287 | 1,164,624 | Yes | Form 4 |
| Henderson Michael ThomasChief Executive Officer | Mar 11 | Mar 13 | S | 8,219 | $74.83 | Sale −$615,028 | 1,156,405 | Yes | Form 4 |
| Henderson Michael ThomasChief Executive Officer | Mar 11 | Mar 13 | S | 3,418 | $75.86 | Sale −$259,289 | 1,152,987 | Yes | Form 4 |
| Dambkowski CarlChief Medical Officer | Mar 4 | Mar 6 | M | 4,125 | $22.86 | $94,298 | 215,273 | Yes | Form 4 |
| Dambkowski CarlChief Medical Officer | Mar 4 | Mar 6 | S | 3,225 | $70.33 | Sale −$226,814 | 212,048 | Yes | Form 4 |
| Dambkowski CarlChief Medical Officer | Mar 4 | Mar 6 | S | 2,075 | $71.98 | Sale −$149,359 | 209,973 | Yes | Form 4 |
| Dambkowski CarlChief Medical Officer | Mar 4 | Mar 6 | S | 200 | $73.26 | Sale −$14,652 | 209,773 | Yes | Form 4 |
| Dambkowski CarlChief Medical Officer | Mar 4 | Mar 6 | M · derivative | 4,125 | $22.86 | $94,298 | 131,290 | Yes | Form 4 |
| Henderson JaneChief Financial Officer | Mar 2 | Mar 4 | S | 300 | $68.27 | Sale −$20,481 | 183,071 | Yes | Form 4 |
| Henderson JaneChief Financial Officer | Mar 2 | Mar 4 | S | 300 | $69.43 | Sale −$20,829 | 182,771 | Yes | Form 4 |
| Henderson JaneChief Financial Officer | Mar 2 | Mar 4 | S | 994 | $70.45 | Sale −$70,027 | 181,777 | Yes | Form 4 |
| Henderson JaneChief Financial Officer | Mar 2 | Mar 4 | S | 406 | $71.66 | Sale −$29,094 | 181,371 | Yes | Form 4 |
| Henderson Michael ThomasChief Executive Officer | Feb 11 | Feb 13 | S | 11,494 | $62.96 | Sale −$723,662 | 1,181,493 | Yes | Form 4 |
| Henderson Michael ThomasChief Executive Officer | Feb 11 | Feb 13 | S | 7,551 | $63.73 | Sale −$481,225 | 1,173,942 | Yes | Form 4 |
| Henderson Michael ThomasChief Executive Officer | Feb 11 | Feb 13 | S | 955 | $64.99 | Sale −$62,065 | 1,172,987 | Yes | Form 4 |
| Dambkowski CarlChief Medical Officer | Feb 4 | Feb 4 | M | 4,125 | $22.86 | $94,298 | 216,648 | Yes | Form 4 |
| Dambkowski CarlChief Medical Officer | Feb 4 | Feb 4 | S | 2,481 | $64.88 | Sale −$160,967 | 214,167 | Yes | Form 4 |
| Dambkowski CarlChief Medical Officer | Feb 4 | Feb 4 | S | 1,420 | $65.83 | Sale −$93,479 | 212,747 | Yes | Form 4 |
| Dambkowski CarlChief Medical Officer | Feb 4 | Feb 4 | S | 1,299 | $66.85 | Sale −$86,838 | 211,448 | Yes | Form 4 |
| Dambkowski CarlChief Medical Officer | Feb 4 | Feb 4 | S | 100 | $67.88 | Sale −$6,788 | 211,348 | Yes | Form 4 |
| Dambkowski CarlChief Medical Officer | Feb 4 | Feb 4 | S | 200 | $68.94 | Sale −$13,788 | 211,148 | Yes | Form 4 |
| Dambkowski CarlChief Medical Officer | Feb 4 | Feb 4 | M · derivative | 4,125 | $22.86 | $94,298 | 135,415 | Yes | Form 4 |
| Henderson JaneChief Financial Officer | Feb 2 | Feb 4 | S | 792 | $65.21 | Sale −$51,646 | 184,579 | Yes | Form 4 |
| Henderson JaneChief Financial Officer | Feb 2 | Feb 4 | S | 1,108 | $66.15 | Sale −$73,294 | 183,471 | Yes | Form 4 |
| Henderson JaneChief Financial Officer | Feb 2 | Feb 4 | S | 100 | $66.89 | Sale −$6,689 | 183,371 | Yes | Form 4 |
| Harwin Peter Evan | Jan 22 | Jan 22 | S | 1,750,000 | $76.30 | Sale −$133,525,000 | 298,647 | No | Form 4 |
| Henderson Michael ThomasChief Executive Officer | Jan 14 | Jan 16 | S | 1,440 | $78.64 | Sale −$113,242 | 1,211,547 | Yes | Form 4 |
| Henderson Michael ThomasChief Executive Officer | Jan 14 | Jan 16 | S | 8,476 | $79.82 | Sale −$676,554 | 1,203,071 | Yes | Form 4 |
| Henderson Michael ThomasChief Executive Officer | Jan 14 | Jan 16 | S | 2,374 | $81.00 | Sale −$192,294 | 1,200,697 | Yes | Form 4 |
| Henderson Michael ThomasChief Executive Officer | Jan 14 | Jan 16 | S | 1,854 | $82.41 | Sale −$152,788 | 1,198,843 | Yes | Form 4 |
| Henderson Michael ThomasChief Executive Officer | Jan 14 | Jan 16 | S | 5,386 | $83.16 | Sale −$447,900 | 1,193,457 | Yes | Form 4 |
| Henderson Michael ThomasChief Executive Officer | Jan 14 | Jan 16 | S | 470 | $83.79 | Sale −$39,381 | 1,192,987 | Yes | Form 4 |
| Dambkowski CarlChief Medical Officer | Jan 7 | Jan 9 | M | 14,025 | $22.86 | $320,612 | 231,223 | Yes | Form 4 |
| Dambkowski CarlChief Medical Officer | Jan 7 | Jan 9 | S | 2,954 | $77.13 | Sale −$227,842 | 228,269 | Yes | Form 4 |
| Dambkowski CarlChief Medical Officer | Jan 7 | Jan 9 | S | 14,820 | $77.90 | Sale −$1,154,478 | 213,449 | Yes | Form 4 |
| Dambkowski CarlChief Medical Officer | Jan 7 | Jan 9 | S | 826 | $79.04 | Sale −$65,287 | 212,623 | Yes | Form 4 |
| Dambkowski CarlChief Medical Officer | Jan 7 | Jan 9 | S | 100 | $80.06 | Sale −$8,006 | 212,523 | Yes | Form 4 |
| Dambkowski CarlChief Medical Officer | Jan 7 | Jan 9 | M · derivative | 14,025 | $22.86 | $320,612 | 139,540 | Yes | Form 4 |
| Henderson JaneChief Financial Officer | Jan 6 | Jan 6 | S | 2,000 | $80.00 | Sale −$160,000 | 185,371 | Yes | Form 4 |
| Henderson JaneChief Financial Officer | Jan 2 | Jan 6 | S | 1,920 | $74.13 | Sale −$142,330 | 191,451 | Yes | Form 4 |
| Henderson JaneChief Financial Officer | Jan 2 | Jan 6 | S | 4,080 | $75.20 | Sale −$306,816 | 187,371 | Yes | Form 4 |
| Henderson JaneChief Financial Officer | Jan 2 | Jan 6 | A · derivative | 83,690 | $75.78 | $6,342,028 | 83,690 | Yes | Form 4 |
| Henderson Michael ThomasChief Executive Officer | Jan 2 | Jan 6 | A · derivative | 253,016 | $75.78 | $19,173,552 | 253,016 | No | Form 4 |
| Dambkowski CarlChief Medical Officer | Jan 2 | Jan 6 | A · derivative | 83,690 | $75.78 | $6,342,028 | 83,690 | No | Form 4 |
| Henderson JaneChief Financial Officer | Dec 19, 2025 | Dec 23, 2025 | S | 1,500 | $80.00 | Sale −$120,000 | 193,371 | Yes | Form 4 |
| Henderson Michael ThomasChief Executive Officer | Dec 10, 2025 | Dec 12, 2025 | S | 9,435 | $74.88 | Sale −$706,493 | 1,223,552 | Yes | Form 4 |
| Henderson Michael ThomasChief Executive Officer | Dec 10, 2025 | Dec 12, 2025 | S | 10,005 | $75.79 | Sale −$758,279 | 1,213,547 | Yes | Form 4 |
| Henderson Michael ThomasChief Executive Officer | Dec 10, 2025 | Dec 12, 2025 | S | 560 | $76.58 | Sale −$42,885 | 1,212,987 | Yes | Form 4 |
| Henderson Michael ThomasChief Executive Officer | Dec 4, 2025 | Dec 5, 2025 | S | 40,000 | $75.01 | Sale −$3,000,400 | 1,232,987 | Yes | Form 4 |
| Henderson JaneChief Financial Officer | Dec 4, 2025 | Dec 5, 2025 | S | 1,500 | $75.00 | Sale −$112,500 | 194,871 | Yes | Form 4 |
| Dambkowski CarlChief Medical Officer | Dec 4, 2025 | Dec 5, 2025 | S | 10,900 | $75.00 | Sale −$817,500 | 271,108 | Yes | Form 4 |
| Henderson JaneChief Financial Officer | Nov 25, 2025 | Nov 28, 2025 | S | 1,500 | $70.00 | Sale −$105,000 | 196,371 | Yes | Form 4 |
| Henderson JaneChief Financial Officer | Nov 14, 2025 | Nov 14, 2025 | S | 2,000 | $65.00 | Sale −$130,000 | 197,871 | Yes | Form 4 |
| Henderson Michael ThomasChief Executive Officer | Nov 13, 2025 | Nov 13, 2025 | S | 3,340 | $61.93 | Sale −$206,846 | 1,289,647 | Yes | Form 4 |
| Henderson Michael ThomasChief Executive Officer | Nov 13, 2025 | Nov 13, 2025 | S | 14,774 | $63.14 | Sale −$932,830 | 1,274,873 | Yes | Form 4 |
| Henderson Michael ThomasChief Executive Officer | Nov 13, 2025 | Nov 13, 2025 | S | 1,786 | $63.89 | Sale −$114,108 | 1,273,087 | Yes | Form 4 |
| Henderson Michael ThomasChief Executive Officer | Nov 13, 2025 | Nov 13, 2025 | S | 100 | $64.52 | Sale −$6,452 | 1,272,987 | Yes | Form 4 |
| Henderson JaneChief Financial Officer | Nov 11, 2025 | Nov 13, 2025 | S | 1,000 | $60.00 | Sale −$60,000 | 199,871 | Yes | Form 4 |
| Dambkowski CarlChief Medical Officer | Nov 5, 2025 | Nov 7, 2025 | M | 8,060 | $22.86 | $184,252 | 292,793 | Yes | Form 4 |
| Dambkowski CarlChief Medical Officer | Nov 5, 2025 | Nov 7, 2025 | S | 2,300 | $53.62 | Sale −$123,326 | 290,493 | Yes | Form 4 |
| Dambkowski CarlChief Medical Officer | Nov 5, 2025 | Nov 7, 2025 | S | 2,200 | $54.83 | Sale −$120,626 | 288,293 | Yes | Form 4 |
| Dambkowski CarlChief Medical Officer | Nov 5, 2025 | Nov 7, 2025 | S | 5,607 | $55.58 | Sale −$311,637 | 282,686 | Yes | Form 4 |
| Dambkowski CarlChief Medical Officer | Nov 5, 2025 | Nov 7, 2025 | S | 678 | $56.51 | Sale −$38,314 | 282,008 | Yes | Form 4 |
| Dambkowski CarlChief Medical Officer | Nov 5, 2025 | Nov 7, 2025 | M · derivative | 8,060 | $22.86 | $184,252 | 153,565 | Yes | Form 4 |
| Shah Nimish P | Oct 10, 2025 | Oct 15, 2025 | P · derivative | 365,853 | $41.00 | Purchase +$14,999,973 | 365,853 | No | Form 4 |
| Dambkowski CarlChief Medical Officer | Oct 1, 2025 | Oct 3, 2025 | M | 2,385 | $22.86 | $54,521 | 289,843 | Yes | Form 4 |
| Dambkowski CarlChief Medical Officer | Oct 1, 2025 | Oct 3, 2025 | S | 5,110 | $39.80 | Sale −$203,378 | 284,733 | Yes | Form 4 |
| Dambkowski CarlChief Medical Officer | Oct 1, 2025 | Oct 3, 2025 | M · derivative | 2,385 | $22.86 | $54,521 | 161,625 | Yes | Form 4 |
| Dambkowski CarlChief Medical Officer | Sep 3, 2025 | Sep 5, 2025 | S | 2,535 | $37.82 | Sale −$95,874 | 233,738 | Yes | Form 4 |
| Dambkowski CarlChief Medical Officer | Sep 3, 2025 | Sep 5, 2025 | S | 190 | $38.55 | Sale −$7,325 | 233,548 | Yes | Form 4 |
| Dambkowski CarlChief Medical Officer | Aug 6, 2025 | Aug 8, 2025 | S | 2,725 | $37.78 | Sale −$102,951 | 236,273 | Yes | Form 4 |
| Dambkowski CarlChief Medical Officer | Jul 2, 2025 | Jul 3, 2025 | M | 7,365 | $22.86 | $168,364 | 249,088 | Yes | Form 4 |
| Dambkowski CarlChief Medical Officer | Jul 2, 2025 | Jul 3, 2025 | S | 6,409 | $44.77 | Sale −$286,931 | 242,679 | Yes | Form 4 |
| Dambkowski CarlChief Medical Officer | Jul 2, 2025 | Jul 3, 2025 | S | 2,935 | $45.49 | Sale −$133,513 | 239,744 | Yes | Form 4 |
| Dambkowski CarlChief Medical Officer | Jul 2, 2025 | Jul 3, 2025 | S | 746 | $46.26 | Sale −$34,510 | 238,998 | Yes | Form 4 |
| Dambkowski CarlChief Medical Officer | Jul 2, 2025 | Jul 3, 2025 | M · derivative | 7,365 | $22.86 | $168,364 | 164,010 | Yes | Form 4 |
| Bollinger Lisa | Jun 17, 2025 | Jun 20, 2025 | A · derivative | 14,461 | $41.66 | $602,445 | 14,461 | No | Form 4 |
| Fox Jennifer A. | Jun 17, 2025 | Jun 20, 2025 | A · derivative | 14,461 | $41.66 | $602,445 | 14,461 | No | Form 4 |
| Gottesdiener Andrew | Jun 17, 2025 | Jun 20, 2025 | A · derivative | 14,461 | $41.66 | $602,445 | 14,461 | No | Form 4 |
| Jones William A Jr | Jun 17, 2025 | Jun 20, 2025 | A · derivative | 14,461 | $41.66 | $602,445 | 14,461 | No | Form 4 |
| McKenna Mark C. | Jun 17, 2025 | Jun 20, 2025 | A · derivative | 14,461 | $41.66 | $602,445 | 14,461 | No | Form 4 |
| Shah Nimish P | Jun 17, 2025 | Jun 20, 2025 | A · derivative | 14,461 | $41.66 | $602,445 | 14,461 | No | Form 4 |
| Fairmount Funds Management LLC | Jun 17, 2025 | Jun 20, 2025 | A · derivative | 14,461 | $41.66 | $602,445 | 14,461 | No | Form 4 |
| Fairmount Funds Management LLC | Jun 17, 2025 | Jun 20, 2025 | A · derivative | 14,461 | $41.66 | $602,445 | 14,461 | No | Form 4 |
| Dambkowski CarlChief Medical Officer | Jun 4, 2025 | Jun 6, 2025 | S | 2,725 | $36.96 | Sale −$100,716 | 241,723 | Yes | Form 4 |
| Dambkowski CarlChief Medical Officer | May 7, 2025 | May 9, 2025 | S | 2,725 | $35.75 | Sale −$97,419 | 244,448 | Yes | Form 4 |
| Dambkowski CarlChief Medical Officer | Apr 2, 2025 | Apr 4, 2025 | S | 2,471 | $35.56 | Sale −$87,869 | 248,562 | Yes | Form 4 |
| Dambkowski CarlChief Medical Officer | Apr 2, 2025 | Apr 4, 2025 | S | 500 | $37.03 | Sale −$18,515 | 248,062 | Yes | Form 4 |
| Dambkowski CarlChief Medical Officer | Apr 2, 2025 | Apr 4, 2025 | S | 889 | $37.59 | Sale −$33,418 | 247,173 | Yes | Form 4 |
| Henderson Michael ThomasChief Executive Officer | Mar 5, 2025 | Mar 7, 2025 | S | 7,326 | $29.98 | Sale −$219,633 | 1,295,661 | Yes | Form 4 |
| Henderson Michael ThomasChief Executive Officer | Mar 5, 2025 | Mar 7, 2025 | S | 2,674 | $30.62 | Sale −$81,878 | 1,292,987 | Yes | Form 4 |
| Dambkowski CarlChief Medical Officer | Mar 5, 2025 | Mar 7, 2025 | S | 1,590 | $30.48 | Sale −$48,463 | 251,033 | Yes | Form 4 |
| Henderson Michael ThomasChief Executive Officer | Feb 5, 2025 | Feb 7, 2025 | S | 15,000 | $40.58 | Sale −$608,700 | 1,302,987 | Yes | Form 4 |
| Dambkowski CarlChief Medical Officer | Feb 5, 2025 | Feb 7, 2025 | M | 795 | $22.86 | $18,174 | 256,143 | Yes | Form 4 |
| Dambkowski CarlChief Medical Officer | Feb 5, 2025 | Feb 7, 2025 | S | 3,520 | $40.69 | Sale −$143,229 | 252,623 | Yes | Form 4 |
| Dambkowski CarlChief Medical Officer | Feb 5, 2025 | Feb 7, 2025 | M · derivative | 795 | $22.86 | $18,174 | 171,375 | Yes | Form 4 |
| Henderson Michael ThomasChief Executive Officer | Jan 31, 2025 | Jan 31, 2025 | M | 8,500 | $22.86 | $194,310 | 1,317,987 | No | Form 4 |
| Henderson Michael ThomasChief Executive Officer | Jan 31, 2025 | Jan 31, 2025 | M · derivative | 8,500 | $22.86 | $194,310 | 390,012 | No | Form 4 |
| Henderson Michael ThomasChief Executive Officer | Jan 8, 2025 | Jan 10, 2025 | S | 12,132 | $48.72 | Sale −$591,071 | 1,312,355 | Yes | Form 4 |
| Henderson Michael ThomasChief Executive Officer | Jan 8, 2025 | Jan 10, 2025 | S | 2,868 | $49.38 | Sale −$141,622 | 1,309,487 | Yes | Form 4 |
| Dambkowski CarlChief Medical Officer | Jan 2, 2025 | Jan 3, 2025 | M | 1,360 | $22.86 | $31,090 | 259,433 | Yes | Form 4 |
| Dambkowski CarlChief Medical Officer | Jan 2, 2025 | Jan 3, 2025 | S | 1,499 | $46.42 | Sale −$69,584 | 257,934 | Yes | Form 4 |
| Dambkowski CarlChief Medical Officer | Jan 2, 2025 | Jan 3, 2025 | S | 2,486 | $47.21 | Sale −$117,364 | 255,448 | Yes | Form 4 |
| Dambkowski CarlChief Medical Officer | Jan 2, 2025 | Jan 3, 2025 | S | 100 | $47.92 | Sale −$4,792 | 255,348 | Yes | Form 4 |
| Dambkowski CarlChief Medical Officer | Jan 2, 2025 | Jan 3, 2025 | M · derivative | 1,360 | $22.86 | $31,090 | 172,170 | Yes | Form 4 |
| McKenna Mark C. | Dec 12, 2024 | Dec 16, 2024 | P | 7,500 | $49.02 | Purchase +$367,650 | 7,500 | No | Form 4 |
| McKenna Mark C. | Dec 12, 2024 | Dec 16, 2024 | P | 12,500 | $49.85 | Purchase +$623,125 | 20,000 | No | Form 4 |
| Dambkowski CarlChief Medical Officer | Dec 11, 2024 | Dec 13, 2024 | M | 1,815 | $22.86 | $41,491 | 262,613 | Yes | Form 4 |
| Dambkowski CarlChief Medical Officer | Dec 11, 2024 | Dec 13, 2024 | S | 4,085 | $48.62 | Sale −$198,613 | 258,528 | Yes | Form 4 |
| Dambkowski CarlChief Medical Officer | Dec 11, 2024 | Dec 13, 2024 | S | 455 | $50.00 | Sale −$22,750 | 258,073 | Yes | Form 4 |
| Dambkowski CarlChief Medical Officer | Dec 11, 2024 | Dec 13, 2024 | M · derivative | 1,815 | $22.86 | $41,491 | 173,530 | Yes | Form 4 |
| Dambkowski CarlChief Medical Officer | Dec 9, 2024 | Dec 11, 2024 | A · derivative | 124,962 | $49.07 | $6,131,885 | 124,962 | No | Form 4 |
| Henderson JaneChief Financial Officer | Dec 9, 2024 | Dec 11, 2024 | A · derivative | 124,962 | $49.07 | $6,131,885 | 124,962 | No | Form 4 |
| Henderson Michael ThomasChief Executive Officer | Dec 9, 2024 | Dec 11, 2024 | A · derivative | 357,036 | $49.07 | $17,519,757 | 357,036 | No | Form 4 |
| Henderson Michael ThomasChief Executive Officer | Dec 4, 2024 | Dec 6, 2024 | S | 13,328 | $46.50 | Sale −$619,752 | 1,326,159 | Yes | Form 4 |
| Henderson Michael ThomasChief Executive Officer | Dec 4, 2024 | Dec 6, 2024 | S | 1,672 | $47.19 | Sale −$78,902 | 1,324,487 | Yes | Form 4 |
| Dambkowski CarlChief Medical Officer | Dec 4, 2024 | Dec 6, 2024 | S | 6,665 | $46.07 | Sale −$307,057 | 260,798 | Yes | Form 4 |
| Henderson Michael ThomasChief Executive Officer | Nov 6, 2024 | Nov 8, 2024 | S | 14,000 | $59.17 | Sale −$828,380 | 1,340,487 | Yes | Form 4 |
| Henderson Michael ThomasChief Executive Officer | Nov 6, 2024 | Nov 8, 2024 | S | 1,000 | $59.94 | Sale −$59,940 | 1,339,487 | Yes | Form 4 |
| Dambkowski CarlChief Medical Officer | Nov 6, 2024 | Nov 8, 2024 | S | 5,326 | $58.91 | Sale −$313,755 | 268,802 | Yes | Form 4 |
| Dambkowski CarlChief Medical Officer | Nov 6, 2024 | Nov 8, 2024 | S | 1,339 | $59.96 | Sale −$80,286 | 267,463 | Yes | Form 4 |
| Henderson Michael ThomasChief Executive Officer | Oct 2, 2024 | Oct 4, 2024 | S | 30,288 | $56.07 | Sale −$1,698,248 | 1,364,199 | Yes | Form 4 |
| Henderson Michael ThomasChief Executive Officer | Oct 2, 2024 | Oct 4, 2024 | S | 9,712 | $56.74 | Sale −$551,059 | 1,354,487 | Yes | Form 4 |
| Dambkowski CarlChief Medical Officer | Oct 2, 2024 | Oct 4, 2024 | S | 5,740 | $56.16 | Sale −$322,358 | 275,053 | Yes | Form 4 |
| Dambkowski CarlChief Medical Officer | Oct 2, 2024 | Oct 4, 2024 | S | 925 | $56.86 | Sale −$52,596 | 274,128 | Yes | Form 4 |
| Henderson Michael ThomasChief Executive Officer | Sep 4, 2024 | Sep 6, 2024 | S | 25,641 | $47.28 | Sale −$1,212,306 | 1,408,846 | Yes | Form 4 |
| Henderson Michael ThomasChief Executive Officer | Sep 4, 2024 | Sep 6, 2024 | S | 14,359 | $48.23 | Sale −$692,535 | 1,394,487 | Yes | Form 4 |
| Dambkowski CarlChief Medical Officer | Sep 4, 2024 | Sep 6, 2024 | S | 5,878 | $47.49 | Sale −$279,146 | 281,580 | Yes | Form 4 |
| Dambkowski CarlChief Medical Officer | Sep 4, 2024 | Sep 6, 2024 | S | 787 | $48.06 | Sale −$37,823 | 280,793 | Yes | Form 4 |
| Henderson JaneChief Financial Officer | Aug 23, 2024 | Aug 23, 2024 | S | 6,000 | $48.26 | Sale −$289,560 | 200,871 | No | Form 4 |
| Henderson Michael ThomasChief Executive Officer | Aug 7, 2024 | Aug 9, 2024 | S | 32,233 | $40.40 | Sale −$1,302,213 | 1,442,254 | Yes | Form 4 |
| Henderson Michael ThomasChief Executive Officer | Aug 7, 2024 | Aug 9, 2024 | S | 7,667 | $41.52 | Sale −$318,334 | 1,434,587 | Yes | Form 4 |
| Henderson Michael ThomasChief Executive Officer | Aug 7, 2024 | Aug 9, 2024 | S | 100 | $42.17 | Sale −$4,217 | 1,434,487 | Yes | Form 4 |
| Dambkowski CarlChief Medical Officer | Aug 7, 2024 | Aug 9, 2024 | S | 6,523 | $40.47 | Sale −$263,986 | 288,270 | Yes | Form 4 |
| Dambkowski CarlChief Medical Officer | Aug 7, 2024 | Aug 9, 2024 | S | 142 | $41.09 | Sale −$5,835 | 288,128 | Yes | Form 4 |
| Dambkowski CarlChief Medical Officer | Aug 7, 2024 | Aug 9, 2024 | S | 670 | $42.56 | Sale −$28,515 | 287,458 | Yes | Form 4 |
| Henderson Michael ThomasChief Executive Officer | Jul 5, 2024 | Jul 5, 2024 | S | 15,000 | $37.26 | Sale −$558,900 | 1,474,487 | Yes | Form 4 |
| Dambkowski CarlChief Medical Officer | Jul 3, 2024 | Jul 5, 2024 | S | 3,852 | $37.29 | Sale −$143,641 | 296,936 | Yes | Form 4 |
| Dambkowski CarlChief Medical Officer | Jul 3, 2024 | Jul 5, 2024 | S | 2,143 | $38.16 | Sale −$81,777 | 294,793 | Yes | Form 4 |
| Harwin Peter Evan | Jun 5, 2024 | Jun 7, 2024 | A · derivative | 10,370 | $43.85 | $454,725 | 10,370 | No | Form 4 |
| Harwin Peter Evan | Jun 5, 2024 | Jun 7, 2024 | A · derivative | 10,370 | $43.85 | $454,725 | 10,370 | No | Form 4 |
| Gottesdiener Andrew | Jun 5, 2024 | Jun 7, 2024 | A · derivative | 10,370 | $43.85 | $454,725 | 10,370 | No | Form 4 |
| Shah Nimish P | Jun 5, 2024 | Jun 7, 2024 | A · derivative | 10,370 | $43.85 | $454,725 | 10,370 | No | Form 4 |
| Fox Jennifer A. | Jun 5, 2024 | Jun 7, 2024 | A · derivative | 10,370 | $43.85 | $454,725 | 10,370 | No | Form 4 |
| Bollinger Lisa | Jun 5, 2024 | Jun 7, 2024 | A · derivative | 8,112 | $43.85 | $355,711 | 8,112 | No | Form 4 |
| McKenna Mark C. | Jun 5, 2024 | Jun 7, 2024 | A · derivative | 10,370 | $43.85 | $454,725 | 10,370 | No | Form 4 |
| Jones William A Jr | Jun 5, 2024 | Jun 7, 2024 | A · derivative | 10,370 | $43.85 | $454,725 | 10,370 | No | Form 4 |
| Bollinger Lisa | May 28, 2024 | May 30, 2024 | A · derivative | 18,550 | $47.86 | $887,803 | 18,550 | No | Form 4 |
| Harwin Peter Evan | Mar 28, 2024 | Apr 1, 2024 | J | 55,913 | not reported | not reported | not reported | No | Form 4 |
| Harwin Peter Evan | Mar 28, 2024 | Apr 1, 2024 | J | 55,913 | not reported | not reported | 2,048,647 | No | Form 4 |
| Harwin Peter Evan | Mar 28, 2024 | Apr 1, 2024 | J · derivative | 221,426 | $0.00 | $0 | not reported | No | Form 4 |
| Harwin Peter Evan | Mar 28, 2024 | Apr 1, 2024 | J · derivative | 221,426 | $0.00 | $0 | 6,743,321 | No | Form 4 |
| Harwin Peter Evan | Jan 29, 2024 | Jan 31, 2024 | J | 892,529 | $0.00 | $0 | not reported | Yes | Form 4 |
| Harwin Peter Evan | Jan 29, 2024 | Jan 31, 2024 | J | 51,166 | $0.00 | $0 | 51,166 | Yes | Form 4 |
| Harwin Peter Evan | Jan 29, 2024 | Jan 31, 2024 | J | 51,166 | $0.00 | $0 | 51,166 | Yes | Form 4 |
| Henderson Michael ThomasChief Executive Officer | Dec 18, 2023 | Dec 20, 2023 | A · derivative | 398,512 | $22.86 | $9,109,984 | 398,512 | No | Form 4 |
| Henderson JaneChief Financial Officer | Dec 18, 2023 | Dec 20, 2023 | A · derivative | 175,345 | $22.86 | $4,008,387 | 175,345 | No | Form 4 |
| Dambkowski CarlChief Medical Officer | Dec 18, 2023 | Dec 20, 2023 | A · derivative | 175,345 | $22.86 | $4,008,387 | 175,345 | No | Form 4 |