AXSMAxsome Therapeutics, Inc.
- Market cap
- $7.60B
- as of 2026-10-23
- Latest close
- $145.04
- as of 2026-10-23
- Sector
- Healthcare
- as of 2026-10-24
- Industry
- Biotechnology
- as of 2026-10-24
Cluster
No cluster in the last 90 days under the default rule (14d · ≥2 insiders · all roles).
Form 4 historysince 2023-10-12
| Insider | Traded | Filed | Type | Shares | Price | Value | Owned after | 10b5-1 plan | Filing |
|---|---|---|---|---|---|---|---|---|---|
| Jacobson Mark L.Chief Operating Officer | Sep 3 | Sep 3 | M | 10,000 | $12.95 | $129,500 | 10,000 | Yes | Form 4 |
| Jacobson Mark L.Chief Operating Officer | Sep 3 | Sep 3 | S | 10,000 | $208.65 | Sale −$2,086,500 | not reported | Yes | Form 4 |
| Jacobson Mark L.Chief Operating Officer | Sep 3 | Sep 3 | M · derivative | 10,000 | $12.95 | $129,500 | 104,954 | Yes | Form 4 |
| Tabuteau HerriotChief Executive Officer | Aug 6 | Aug 7 | M | 4,660 | $4.95 | $23,067 | 11,889 | Yes | Form 4 |
| Tabuteau HerriotChief Executive Officer | Aug 6 | Aug 7 | S | 4,660 | $213.95 | Sale −$997,007 | 7,229 | Yes | Form 4 |
| Tabuteau HerriotChief Executive Officer | Aug 6 | Aug 7 | M · derivative | 4,660 | $213.95 | $997,007 | not reported | Yes | Form 4 |
| Tabuteau HerriotChief Executive Officer | Aug 5 | Aug 7 | M | 45,004 | $4.95 | $222,770 | 52,233 | Yes | Form 4 |
| Tabuteau HerriotChief Executive Officer | Aug 5 | Aug 7 | S | 45,004 | $212.01 | Sale −$9,541,298 | 7,229 | Yes | Form 4 |
| Tabuteau HerriotChief Executive Officer | Aug 5 | Aug 7 | M · derivative | 45,004 | $212.01 | $9,541,298 | 4,660 | Yes | Form 4 |
| Tabuteau HerriotChief Executive Officer | Jul 1 | Jul 1 | M | 49,666 | $4.95 | $245,847 | 56,895 | Yes | Form 4 |
| Tabuteau HerriotChief Executive Officer | Jul 1 | Jul 1 | S | 49,666 | $240.25 | Sale −$11,932,257 | 7,229 | Yes | Form 4 |
| Tabuteau HerriotChief Executive Officer | Jul 1 | Jul 1 | M · derivative | 49,666 | $240.25 | $11,932,257 | 49,664 | Yes | Form 4 |
| Jeffs Roger | Jun 11 | Jun 11 | S | 286 | $249.12 | Sale −$71,248 | 58,367 | Yes | Form 4 |
| Jeffs Roger | Jun 10 | Jun 11 | S | 286 | $246.18 | Sale −$70,407 | 58,653 | Yes | Form 4 |
| Coleman Mark | Jun 10 | Jun 10 | S | 643 | $249.00 | Sale −$160,107 | 30,389 | Yes | Form 4 |
| Mahony Susan | Jun 10 | Jun 10 | S | 300 | $246.18 | Sale −$73,854 | 829 | Yes | Form 4 |
| Mahony Susan | Jun 9 | Jun 10 | S | 300 | $237.21 | Sale −$71,163 | 1,129 | Yes | Form 4 |
| Coleman Mark | Jun 8 | Jun 10 | M | 1,429 | not reported | not reported | 31,032 | Yes | Form 4 |
| Coleman Mark | Jun 8 | Jun 10 | M · derivative | 1,429 | $0.00 | $0 | not reported | Yes | Form 4 |
| Mahony Susan | Jun 8 | Jun 10 | M | 1,429 | not reported | not reported | 1,429 | Yes | Form 4 |
| Mahony Susan | Jun 8 | Jun 10 | M · derivative | 1,429 | $0.00 | $0 | not reported | Yes | Form 4 |
| Saad Mark E | Jun 8 | Jun 10 | M | 1,429 | not reported | not reported | 11,431 | No | Form 4 |
| Saad Mark E | Jun 8 | Jun 10 | M · derivative | 1,429 | $0.00 | $0 | not reported | No | Form 4 |
| Jeffs Roger | Jun 8 | Jun 10 | M | 1,429 | not reported | not reported | 58,939 | No | Form 4 |
| Jeffs Roger | Jun 8 | Jun 10 | M · derivative | 1,429 | $0.00 | $0 | not reported | No | Form 4 |
| Pizzie NickChief Financial Officer | Jun 9 | Jun 9 | M | 33,000 | $3.50 | $115,500 | 75,867 | Yes | Form 4 |
| Pizzie NickChief Financial Officer | Jun 9 | Jun 9 | S | 33,000 | $240.09 | Sale −$7,922,970 | 42,867 | Yes | Form 4 |
| Pizzie NickChief Financial Officer | Jun 9 | Jun 9 | M · derivative | 33,000 | $3.50 | $115,500 | 72,000 | Yes | Form 4 |
| Tabuteau HerriotChief Executive Officer | Jun 9 | Jun 9 | M | 49,670 | $4.95 | $245,867 | 56,899 | Yes | Form 4 |
| Tabuteau HerriotChief Executive Officer | Jun 9 | Jun 9 | S | 49,670 | $241.01 | Sale −$11,970,967 | 7,229 | Yes | Form 4 |
| Tabuteau HerriotChief Executive Officer | Jun 9 | Jun 9 | M · derivative | 49,670 | $241.01 | $11,970,967 | 99,330 | Yes | Form 4 |
| Jeffs Roger | Jun 5 | Jun 9 | A · derivative | 1,721 | $0.00 | $0 | 1,721 | No | Form 4 |
| Saad Mark E | Jun 5 | Jun 9 | A · derivative | 1,721 | $0.00 | $0 | 1,721 | No | Form 4 |
| Mahony Susan | Jun 5 | Jun 9 | A · derivative | 1,721 | $0.00 | $0 | 1,721 | No | Form 4 |
| Coleman Mark | Jun 5 | Jun 9 | A · derivative | 1,721 | $0.00 | $0 | 1,721 | No | Form 4 |
| Coleman Mark | Jun 2 | Jun 2 | S | 5,537 | $223.39 | Sale −$1,236,910 | 29,603 | Yes | Form 4 |
| Coleman Mark | Jun 1 | Jun 2 | S | 6,000 | $230.30 | Sale −$1,381,800 | 35,140 | Yes | Form 4 |
| Coleman Mark | May 29 | Jun 2 | S | 6,000 | $233.46 | Sale −$1,400,760 | 41,140 | Yes | Form 4 |
| Jacobson Mark L.Chief Operating Officer | May 5 | May 5 | M | 233 | $12.95 | $3,017 | 233 | Yes | Form 4 |
| Jacobson Mark L.Chief Operating Officer | May 5 | May 5 | S | 233 | $228.18 | Sale −$53,166 | not reported | Yes | Form 4 |
| Jacobson Mark L.Chief Operating Officer | May 5 | May 5 | M · derivative | 233 | $12.95 | $3,017 | 114,954 | Yes | Form 4 |
| Jacobson Mark L.Chief Operating Officer | May 4 | May 5 | M | 4,517 | $12.95 | $58,495 | 4,517 | Yes | Form 4 |
| Jacobson Mark L.Chief Operating Officer | May 4 | May 5 | S | 4,517 | $227.94 | Sale −$1,029,605 | not reported | Yes | Form 4 |
| Jacobson Mark L.Chief Operating Officer | May 4 | May 5 | M · derivative | 4,517 | $12.95 | $58,495 | 115,187 | Yes | Form 4 |
| Maizel AriChief Commercial Officer | Apr 22 | Apr 23 | M | 7,500 | $70.73 | $530,475 | 7,500 | Yes | Form 4 |
| Maizel AriChief Commercial Officer | Apr 22 | Apr 23 | S | 7,500 | $182.42 | Sale −$1,368,150 | not reported | Yes | Form 4 |
| Maizel AriChief Commercial Officer | Apr 22 | Apr 23 | M · derivative | 7,500 | $70.73 | $530,475 | 23,710 | Yes | Form 4 |
| Murdock Hunter R.General Counsel | Apr 21 | Apr 23 | A · derivative | 7,224 | $0.00 | $0 | 7,224 | No | Form 4 |
| Pizzie NickChief Financial Officer | Apr 21 | Apr 23 | A · derivative | 8,188 | $0.00 | $0 | 8,188 | No | Form 4 |
| Maizel AriChief Commercial Officer | Apr 21 | Apr 23 | A · derivative | 7,224 | $0.00 | $0 | 7,224 | No | Form 4 |
| Tabuteau HerriotChief Executive Officer | Apr 21 | Apr 23 | A · derivative | 24,081 | $0.00 | $0 | 24,081 | No | Form 4 |
| Jacobson Mark L.Chief Operating Officer | Apr 21 | Apr 23 | A · derivative | 8,669 | $0.00 | $0 | 8,669 | No | Form 4 |
| Jacobson Mark L.Chief Operating Officer | Feb 26 | Feb 27 | M | 35,378 | $2.85 | $100,827 | 35,378 | Yes | Form 4 |
| Jacobson Mark L.Chief Operating Officer | Feb 26 | Feb 27 | S | 35,378 | $161.88 | Sale −$5,726,991 | not reported | Yes | Form 4 |
| Jacobson Mark L.Chief Operating Officer | Feb 26 | Feb 27 | M · derivative | 35,378 | $2.85 | $100,827 | not reported | Yes | Form 4 |
| Coleman Mark | Feb 26 | Feb 27 | S | 25,000 | $161.11 | Sale −$4,027,750 | 47,140 | Yes | Form 4 |
| Jacobson Mark L.Chief Operating Officer | Feb 26 | Feb 27 | A · derivative | 19,663 | $0.00 | $0 | 19,663 | No | Form 4 |
| Maizel AriChief Commercial Officer | Feb 26 | Feb 27 | A · derivative | 16,385 | $0.00 | $0 | 16,385 | No | Form 4 |
| Murdock Hunter R.General Counsel | Feb 26 | Feb 27 | A · derivative | 16,385 | $0.00 | $0 | 16,385 | No | Form 4 |
| Pizzie NickChief Financial Officer | Feb 26 | Feb 27 | A · derivative | 18,570 | $0.00 | $0 | 18,570 | No | Form 4 |
| Tabuteau HerriotChief Executive Officer | Feb 26 | Feb 27 | A · derivative | 54,623 | $0.00 | $0 | 54,623 | No | Form 4 |
| Coleman Mark | Feb 23 | Feb 25 | M | 6,250 | $4.95 | $30,938 | 72,140 | No | Form 4 |
| Coleman Mark | Feb 23 | Feb 25 | M · derivative | 6,250 | $4.95 | $30,938 | 7,721 | No | Form 4 |
| Coleman Mark | Feb 20 | Feb 23 | M | 12,485 | $4.95 | $61,801 | 65,890 | No | Form 4 |
| Coleman Mark | Feb 20 | Feb 23 | M · derivative | 12,485 | $4.95 | $61,801 | 13,971 | No | Form 4 |
| Coleman Mark | Feb 10 | Feb 10 | M | 5,193 | $8.02 | $41,648 | 53,405 | No | Form 4 |
| Coleman Mark | Feb 10 | Feb 10 | M · derivative | 5,193 | $8.02 | $41,648 | not reported | No | Form 4 |
| Tabuteau HerriotChief Executive Officer | Feb 2 | Feb 2 | M | 32,410 | $8.02 | $259,928 | 39,639 | Yes | Form 4 |
| Tabuteau HerriotChief Executive Officer | Feb 2 | Feb 2 | S | 32,410 | $185.60 | Sale −$6,015,296 | 7,229 | Yes | Form 4 |
| Tabuteau HerriotChief Executive Officer | Feb 2 | Feb 2 | M · derivative | 32,410 | $185.60 | $6,015,296 | not reported | Yes | Form 4 |
| Pizzie NickChief Financial Officer | Jan 22 | Jan 23 | M | 12,000 | $3.50 | $42,000 | 54,588 | Yes | Form 4 |
| Pizzie NickChief Financial Officer | Jan 22 | Jan 23 | S | 12,000 | $187.92 | Sale −$2,255,040 | 42,588 | Yes | Form 4 |
| Pizzie NickChief Financial Officer | Jan 22 | Jan 23 | M · derivative | 12,000 | $3.50 | $42,000 | 105,000 | Yes | Form 4 |
| Maizel AriChief Commercial Officer | Jan 21 | Jan 23 | M | 7,500 | $70.73 | $530,475 | 7,500 | Yes | Form 4 |
| Maizel AriChief Commercial Officer | Jan 21 | Jan 23 | S | 7,500 | $184.44 | Sale −$1,383,300 | not reported | Yes | Form 4 |
| Maizel AriChief Commercial Officer | Jan 21 | Jan 23 | M · derivative | 7,500 | $70.73 | $530,475 | 31,210 | Yes | Form 4 |
| Tabuteau HerriotChief Executive Officer | Jan 7 | Jan 7 | M | 31,261 | $8.02 | $250,713 | 38,490 | Yes | Form 4 |
| Tabuteau HerriotChief Executive Officer | Jan 7 | Jan 7 | S | 31,261 | $170.38 | Sale −$5,326,249 | 7,229 | Yes | Form 4 |
| Tabuteau HerriotChief Executive Officer | Jan 7 | Jan 7 | M · derivative | 31,261 | $170.38 | $5,326,249 | 32,410 | Yes | Form 4 |
| Tabuteau HerriotChief Executive Officer | Jan 6 | Jan 7 | M | 29,450 | $8.02 | $236,189 | 36,679 | Yes | Form 4 |
| Tabuteau HerriotChief Executive Officer | Jan 6 | Jan 7 | S | 29,450 | $172.33 | Sale −$5,075,119 | 7,229 | Yes | Form 4 |
| Tabuteau HerriotChief Executive Officer | Jan 6 | Jan 7 | M · derivative | 29,450 | $172.33 | $5,075,119 | 63,671 | Yes | Form 4 |
| Tabuteau HerriotChief Executive Officer | Jan 5 | Jan 7 | M | 78,703 | $8.02 | $631,198 | 85,932 | Yes | Form 4 |
| Tabuteau HerriotChief Executive Officer | Jan 5 | Jan 7 | S | 78,703 | $171.28 | Sale −$13,480,250 | 7,229 | Yes | Form 4 |
| Tabuteau HerriotChief Executive Officer | Jan 5 | Jan 7 | M · derivative | 78,703 | $171.28 | $13,480,250 | 93,121 | Yes | Form 4 |
| Saad Mark E | Dec 31, 2025 | Jan 2 | M | 6,231 | $8.02 | $49,973 | 16,233 | Yes | Form 4 |
| Saad Mark E | Dec 31, 2025 | Jan 2 | S | 6,231 | $165.18 | Sale −$1,029,237 | 10,002 | Yes | Form 4 |
| Saad Mark E | Dec 31, 2025 | Jan 2 | M | 31,346 | $4.95 | $155,163 | 41,348 | Yes | Form 4 |
| Saad Mark E | Dec 31, 2025 | Jan 2 | S | 31,346 | $165.18 | Sale −$5,177,732 | 10,002 | Yes | Form 4 |
| Saad Mark E | Dec 31, 2025 | Jan 2 | M · derivative | 6,231 | $8.02 | $49,973 | not reported | Yes | Form 4 |
| Saad Mark E | Dec 31, 2025 | Jan 2 | M · derivative | 31,346 | $4.95 | $155,163 | not reported | Yes | Form 4 |
| Tabuteau HerriotChief Executive Officer | Dec 4, 2025 | Dec 4, 2025 | M | 10,558 | $8.02 | $84,675 | 17,787 | Yes | Form 4 |
| Tabuteau HerriotChief Executive Officer | Dec 4, 2025 | Dec 4, 2025 | S | 10,558 | $148.18 | Sale −$1,564,484 | 7,229 | Yes | Form 4 |
| Tabuteau HerriotChief Executive Officer | Dec 4, 2025 | Dec 4, 2025 | M · derivative | 10,558 | $148.18 | $1,564,484 | 171,824 | Yes | Form 4 |
| Tabuteau HerriotChief Executive Officer | Dec 3, 2025 | Dec 4, 2025 | M | 20,163 | $8.02 | $161,707 | 27,392 | Yes | Form 4 |
| Tabuteau HerriotChief Executive Officer | Dec 3, 2025 | Dec 4, 2025 | S | 20,163 | $146.94 | Sale −$2,962,751 | 7,229 | Yes | Form 4 |
| Tabuteau HerriotChief Executive Officer | Dec 3, 2025 | Dec 4, 2025 | M · derivative | 20,163 | $146.94 | $2,962,751 | 182,382 | Yes | Form 4 |
| Tabuteau HerriotChief Executive Officer | Dec 2, 2025 | Dec 4, 2025 | M | 49,252 | $8.02 | $395,001 | 56,481 | Yes | Form 4 |
| Tabuteau HerriotChief Executive Officer | Dec 2, 2025 | Dec 4, 2025 | S | 49,252 | $144.59 | Sale −$7,121,347 | 7,229 | Yes | Form 4 |
| Tabuteau HerriotChief Executive Officer | Dec 2, 2025 | Dec 4, 2025 | M · derivative | 49,252 | $144.59 | $7,121,347 | 202,545 | Yes | Form 4 |
| Tabuteau HerriotChief Executive Officer | Nov 5, 2025 | Nov 5, 2025 | M | 21,775 | $8.02 | $174,636 | 29,004 | Yes | Form 4 |
| Tabuteau HerriotChief Executive Officer | Nov 5, 2025 | Nov 5, 2025 | S | 21,775 | $134.49 | Sale −$2,928,520 | 7,229 | Yes | Form 4 |
| Tabuteau HerriotChief Executive Officer | Nov 5, 2025 | Nov 5, 2025 | M · derivative | 21,775 | $134.49 | $2,928,520 | 251,797 | Yes | Form 4 |
| Tabuteau HerriotChief Executive Officer | Nov 4, 2025 | Nov 5, 2025 | M | 50,459 | $8.02 | $404,681 | 57,688 | Yes | Form 4 |
| Tabuteau HerriotChief Executive Officer | Nov 4, 2025 | Nov 5, 2025 | S | 50,459 | $133.79 | Sale −$6,750,910 | 7,229 | Yes | Form 4 |
| Tabuteau HerriotChief Executive Officer | Nov 4, 2025 | Nov 5, 2025 | M · derivative | 50,459 | $133.79 | $6,750,910 | 273,572 | Yes | Form 4 |
| Tabuteau HerriotChief Executive Officer | Nov 3, 2025 | Nov 5, 2025 | M | 91,705 | $8.02 | $735,474 | 98,934 | Yes | Form 4 |
| Tabuteau HerriotChief Executive Officer | Nov 3, 2025 | Nov 5, 2025 | S | 91,705 | $132.34 | Sale −$12,136,240 | 7,229 | Yes | Form 4 |
| Tabuteau HerriotChief Executive Officer | Nov 3, 2025 | Nov 5, 2025 | M · derivative | 91,705 | $132.34 | $12,136,240 | 324,031 | Yes | Form 4 |
| Tabuteau HerriotChief Executive Officer | Oct 8, 2025 | Oct 8, 2025 | M | 12,774 | $8.02 | $102,447 | 20,003 | Yes | Form 4 |
| Tabuteau HerriotChief Executive Officer | Oct 8, 2025 | Oct 8, 2025 | S | 12,774 | $118.84 | Sale −$1,518,062 | 7,229 | Yes | Form 4 |
| Tabuteau HerriotChief Executive Officer | Oct 8, 2025 | Oct 8, 2025 | M · derivative | 12,774 | $118.84 | $1,518,062 | 415,736 | Yes | Form 4 |
| Tabuteau HerriotChief Executive Officer | Oct 7, 2025 | Oct 8, 2025 | M | 13,390 | $8.02 | $107,388 | 20,619 | Yes | Form 4 |
| Tabuteau HerriotChief Executive Officer | Oct 7, 2025 | Oct 8, 2025 | S | 13,390 | $118.77 | Sale −$1,590,330 | 7,229 | Yes | Form 4 |
| Tabuteau HerriotChief Executive Officer | Oct 7, 2025 | Oct 8, 2025 | M · derivative | 13,390 | $118.77 | $1,590,330 | 428,510 | Yes | Form 4 |
| Tabuteau HerriotChief Executive Officer | Oct 6, 2025 | Oct 8, 2025 | M | 19,220 | $8.02 | $154,144 | 26,449 | Yes | Form 4 |
| Tabuteau HerriotChief Executive Officer | Oct 6, 2025 | Oct 8, 2025 | S | 19,220 | $120.17 | Sale −$2,309,667 | 7,229 | Yes | Form 4 |
| Tabuteau HerriotChief Executive Officer | Oct 6, 2025 | Oct 8, 2025 | M · derivative | 19,220 | $120.17 | $2,309,667 | 441,900 | Yes | Form 4 |
| Jacobson Mark L.Chief Operating Officer | Sep 22, 2025 | Sep 22, 2025 | M | 10,000 | $2.85 | $28,500 | 10,000 | Yes | Form 4 |
| Jacobson Mark L.Chief Operating Officer | Sep 22, 2025 | Sep 22, 2025 | S | 10,000 | $115.96 | Sale −$1,159,600 | not reported | Yes | Form 4 |
| Jacobson Mark L.Chief Operating Officer | Sep 22, 2025 | Sep 22, 2025 | M · derivative | 10,000 | $2.85 | $28,500 | 35,378 | Yes | Form 4 |
| Jacobson Mark L.Chief Operating Officer | Sep 16, 2025 | Sep 17, 2025 | S | 5,783 | $116.19 | Sale −$671,927 | not reported | Yes | Form 4 |
| Jacobson Mark L.Chief Operating Officer | Sep 16, 2025 | Sep 17, 2025 | M | 25,000 | $4.95 | $123,750 | 25,000 | Yes | Form 4 |
| Jacobson Mark L.Chief Operating Officer | Sep 16, 2025 | Sep 17, 2025 | M | 15,000 | $4.85 | $72,750 | 40,000 | Yes | Form 4 |
| Jacobson Mark L.Chief Operating Officer | Sep 16, 2025 | Sep 17, 2025 | S | 40,000 | $114.23 | Sale −$4,569,200 | not reported | Yes | Form 4 |
| Jacobson Mark L.Chief Operating Officer | Sep 16, 2025 | Sep 17, 2025 | M · derivative | 25,000 | $4.95 | $123,750 | not reported | Yes | Form 4 |
| Jacobson Mark L.Chief Operating Officer | Sep 16, 2025 | Sep 17, 2025 | M · derivative | 15,000 | $4.85 | $72,750 | not reported | Yes | Form 4 |
| Tabuteau HerriotChief Executive Officer | Sep 16, 2025 | Sep 16, 2025 | M | 19,719 | $8.02 | $158,146 | 26,948 | Yes | Form 4 |
| Tabuteau HerriotChief Executive Officer | Sep 16, 2025 | Sep 16, 2025 | S | 19,719 | $114.19 | Sale −$2,251,713 | 7,229 | Yes | Form 4 |
| Tabuteau HerriotChief Executive Officer | Sep 16, 2025 | Sep 16, 2025 | M · derivative | 19,719 | $114.19 | $2,251,713 | 461,120 | Yes | Form 4 |
| Tabuteau HerriotChief Executive Officer | Sep 15, 2025 | Sep 16, 2025 | M | 15,254 | $8.02 | $122,337 | 22,483 | Yes | Form 4 |
| Tabuteau HerriotChief Executive Officer | Sep 15, 2025 | Sep 16, 2025 | S | 15,254 | $117.37 | Sale −$1,790,362 | 7,229 | Yes | Form 4 |
| Tabuteau HerriotChief Executive Officer | Sep 15, 2025 | Sep 16, 2025 | M · derivative | 15,254 | $117.37 | $1,790,362 | 480,839 | Yes | Form 4 |
| Tabuteau HerriotChief Executive Officer | Sep 12, 2025 | Sep 16, 2025 | M | 27,907 | $8.02 | $223,814 | 35,136 | Yes | Form 4 |
| Tabuteau HerriotChief Executive Officer | Sep 12, 2025 | Sep 16, 2025 | S | 27,907 | $118.96 | Sale −$3,319,817 | 7,229 | Yes | Form 4 |
| Tabuteau HerriotChief Executive Officer | Sep 12, 2025 | Sep 16, 2025 | M · derivative | 27,907 | $118.96 | $3,319,817 | 496,093 | Yes | Form 4 |
| Coleman Mark | Sep 8, 2025 | Sep 9, 2025 | P | 800 | $127.20 | Purchase +$101,760 | 47,437 | No | Form 4 |
| Coleman Mark | Sep 8, 2025 | Sep 9, 2025 | P | 287 | $127.30 | Purchase +$36,535 | 47,724 | No | Form 4 |
| Coleman Mark | Sep 8, 2025 | Sep 9, 2025 | P | 488 | $127.40 | Purchase +$62,171 | 48,212 | No | Form 4 |
| Saad Mark E | Sep 5, 2025 | Sep 5, 2025 | M | 9,127 | $9.00 | $82,143 | 19,129 | Yes | Form 4 |
| Saad Mark E | Sep 5, 2025 | Sep 5, 2025 | S | 9,127 | $125.07 | Sale −$1,141,514 | 10,002 | Yes | Form 4 |
| Saad Mark E | Sep 5, 2025 | Sep 5, 2025 | M · derivative | 9,127 | $9.00 | $82,143 | not reported | Yes | Form 4 |
| Jeffs Roger | Sep 2, 2025 | Sep 2, 2025 | S | 13,464 | $123.68 | Sale −$1,665,228 | 57,510 | Yes | Form 4 |
| Jeffs Roger | Aug 29, 2025 | Aug 29, 2025 | S | 20,000 | $121.27 | Sale −$2,425,400 | 70,974 | Yes | Form 4 |
| Jeffs Roger | Aug 28, 2025 | Aug 29, 2025 | S | 20,000 | $121.60 | Sale −$2,432,000 | 90,974 | Yes | Form 4 |
| Jeffs Roger | Aug 27, 2025 | Aug 29, 2025 | S | 20,000 | $122.30 | Sale −$2,446,000 | 110,974 | Yes | Form 4 |
| Jeffs Roger | Aug 26, 2025 | Aug 26, 2025 | S | 20,000 | $120.03 | Sale −$2,400,600 | 130,974 | Yes | Form 4 |
| Jeffs Roger | Aug 22, 2025 | Aug 26, 2025 | S | 16,694 | $120.08 | Sale −$2,004,616 | 150,974 | Yes | Form 4 |
| Murdock Hunter R.General Counsel | Jun 23, 2025 | Jun 23, 2025 | M | 6,014 | $29.91 | $179,879 | 6,014 | Yes | Form 4 |
| Murdock Hunter R.General Counsel | Jun 23, 2025 | Jun 23, 2025 | S | 6,014 | $100.12 | Sale −$602,122 | not reported | Yes | Form 4 |
| Murdock Hunter R.General Counsel | Jun 23, 2025 | Jun 23, 2025 | M · derivative | 6,014 | $29.91 | $179,879 | 16,369 | Yes | Form 4 |
| Murdock Hunter R.General Counsel | Jun 20, 2025 | Jun 23, 2025 | M | 7,500 | $29.91 | $224,325 | 7,500 | Yes | Form 4 |
| Murdock Hunter R.General Counsel | Jun 20, 2025 | Jun 23, 2025 | S | 7,500 | $102.47 | Sale −$768,525 | not reported | Yes | Form 4 |
| Murdock Hunter R.General Counsel | Jun 20, 2025 | Jun 23, 2025 | M · derivative | 7,500 | $29.91 | $224,325 | 22,383 | Yes | Form 4 |
| Murdock Hunter R.General Counsel | Jun 18, 2025 | Jun 18, 2025 | M | 7,500 | $29.91 | $224,325 | 7,500 | Yes | Form 4 |
| Murdock Hunter R.General Counsel | Jun 18, 2025 | Jun 18, 2025 | S | 7,500 | $100.90 | Sale −$756,750 | not reported | Yes | Form 4 |
| Murdock Hunter R.General Counsel | Jun 18, 2025 | Jun 18, 2025 | M · derivative | 7,500 | $29.91 | $224,325 | 29,883 | Yes | Form 4 |
| Murdock Hunter R.General Counsel | Jun 17, 2025 | Jun 18, 2025 | M | 7,500 | $29.91 | $224,325 | 7,500 | Yes | Form 4 |
| Murdock Hunter R.General Counsel | Jun 17, 2025 | Jun 18, 2025 | S | 7,500 | $100.26 | Sale −$751,950 | not reported | Yes | Form 4 |
| Murdock Hunter R.General Counsel | Jun 17, 2025 | Jun 18, 2025 | M · derivative | 7,500 | $29.91 | $224,325 | 37,383 | Yes | Form 4 |
| Murdock Hunter R.General Counsel | Jun 16, 2025 | Jun 18, 2025 | M | 7,500 | $29.91 | $224,325 | 7,500 | Yes | Form 4 |
| Murdock Hunter R.General Counsel | Jun 16, 2025 | Jun 18, 2025 | S | 7,500 | $102.42 | Sale −$768,150 | not reported | Yes | Form 4 |
| Murdock Hunter R.General Counsel | Jun 16, 2025 | Jun 18, 2025 | M · derivative | 7,500 | $29.91 | $224,325 | 44,883 | Yes | Form 4 |
| Jacobson Mark L.Chief Operating Officer | Jun 9, 2025 | Jun 10, 2025 | M | 25,000 | $8.02 | $200,500 | 30,783 | Yes | Form 4 |
| Jacobson Mark L.Chief Operating Officer | Jun 9, 2025 | Jun 10, 2025 | S | 25,000 | $110.44 | Sale −$2,761,000 | 5,783 | Yes | Form 4 |
| Jacobson Mark L.Chief Operating Officer | Jun 9, 2025 | Jun 10, 2025 | M · derivative | 25,000 | $8.02 | $200,500 | not reported | Yes | Form 4 |
| Mahony Susan | Jun 6, 2025 | Jun 10, 2025 | A · derivative | 3,166 | $111.91 | $354,307 | 3,166 | No | Form 4 |
| Mahony Susan | Jun 6, 2025 | Jun 10, 2025 | A · derivative | 1,429 | $0.00 | $0 | 1,429 | No | Form 4 |
| Saad Mark E | Jun 6, 2025 | Jun 10, 2025 | A · derivative | 3,166 | $111.91 | $354,307 | 3,166 | No | Form 4 |
| Saad Mark E | Jun 6, 2025 | Jun 10, 2025 | A · derivative | 1,429 | $0.00 | $0 | 1,429 | No | Form 4 |
| Jeffs Roger | Jun 6, 2025 | Jun 10, 2025 | A · derivative | 3,166 | $111.91 | $354,307 | 3,166 | No | Form 4 |
| Jeffs Roger | Jun 6, 2025 | Jun 10, 2025 | A · derivative | 1,429 | $0.00 | $0 | 1,429 | No | Form 4 |
| Coleman Mark | Jun 6, 2025 | Jun 10, 2025 | A · derivative | 3,166 | $111.91 | $354,307 | 3,166 | No | Form 4 |
| Coleman Mark | Jun 6, 2025 | Jun 10, 2025 | A · derivative | 1,429 | $0.00 | $0 | 1,429 | No | Form 4 |
| Coleman Mark | May 28, 2025 | May 29, 2025 | S | 3,750 | $103.43 | Sale −$387,863 | 46,637 | Yes | Form 4 |
| Coleman Mark | May 27, 2025 | May 29, 2025 | S | 3,750 | $105.47 | Sale −$395,513 | 50,387 | Yes | Form 4 |
| Jacobson Mark L.Chief Operating Officer | May 28, 2025 | May 28, 2025 | M | 20,000 | $6.47 | $129,400 | 25,783 | Yes | Form 4 |
| Jacobson Mark L.Chief Operating Officer | May 28, 2025 | May 28, 2025 | S | 20,000 | $103.45 | Sale −$2,069,000 | 5,783 | Yes | Form 4 |
| Jacobson Mark L.Chief Operating Officer | May 28, 2025 | May 28, 2025 | M · derivative | 20,000 | $6.47 | $129,400 | not reported | Yes | Form 4 |
| Jacobson Mark L.Chief Operating Officer | May 27, 2025 | May 28, 2025 | M | 20,673 | $6.47 | $133,754 | 26,456 | Yes | Form 4 |
| Jacobson Mark L.Chief Operating Officer | May 27, 2025 | May 28, 2025 | S | 20,673 | $104.66 | Sale −$2,163,636 | 5,783 | Yes | Form 4 |
| Jacobson Mark L.Chief Operating Officer | May 27, 2025 | May 28, 2025 | M · derivative | 20,673 | $6.47 | $133,754 | not reported | Yes | Form 4 |
| Coleman Mark | May 20, 2025 | May 20, 2025 | S | 3,000 | $107.49 | Sale −$322,470 | 54,137 | No | Form 4 |
| Tabuteau HerriotChief Executive Officer | Feb 24, 2025 | Feb 25, 2025 | A · derivative | 28,609 | $0.00 | $0 | 28,609 | No | Form 4 |
| Jacobson Mark L.Chief Operating Officer | Feb 24, 2025 | Feb 25, 2025 | A · derivative | 10,769 | $0.00 | $0 | 10,769 | No | Form 4 |
| Pizzie NickChief Financial Officer | Feb 24, 2025 | Feb 25, 2025 | A · derivative | 9,423 | $0.00 | $0 | 9,423 | No | Form 4 |
| Murdock Hunter R.General Counsel | Feb 24, 2025 | Feb 25, 2025 | A · derivative | 7,740 | $0.00 | $0 | 7,740 | No | Form 4 |
| Maizel AriChief Commercial Officer | Feb 24, 2025 | Feb 25, 2025 | A · derivative | 7,740 | $0.00 | $0 | 7,740 | No | Form 4 |
| Tabuteau HerriotChief Executive Officer | Feb 21, 2025 | Feb 25, 2025 | A · derivative | 28,887 | $137.75 | $3,979,184 | 28,887 | No | Form 4 |
| Tabuteau HerriotChief Executive Officer | Feb 21, 2025 | Feb 25, 2025 | A · derivative | 28,609 | $0.00 | $0 | 28,609 | No | Form 4 |
| Jacobson Mark L.Chief Operating Officer | Feb 21, 2025 | Feb 25, 2025 | A · derivative | 10,875 | $137.75 | $1,498,031 | 10,875 | No | Form 4 |
| Jacobson Mark L.Chief Operating Officer | Feb 21, 2025 | Feb 25, 2025 | A · derivative | 10,769 | $0.00 | $0 | 10,769 | No | Form 4 |
| Pizzie NickChief Financial Officer | Feb 21, 2025 | Feb 25, 2025 | A · derivative | 9,516 | $137.75 | $1,310,829 | 9,516 | No | Form 4 |
| Pizzie NickChief Financial Officer | Feb 21, 2025 | Feb 25, 2025 | A · derivative | 9,423 | $0.00 | $0 | 9,423 | No | Form 4 |
| Murdock Hunter R.General Counsel | Feb 21, 2025 | Feb 25, 2025 | A · derivative | 7,816 | $137.75 | $1,076,654 | 7,816 | No | Form 4 |
| Murdock Hunter R.General Counsel | Feb 21, 2025 | Feb 25, 2025 | A · derivative | 7,740 | $0.00 | $0 | 7,740 | No | Form 4 |
| Maizel AriChief Commercial Officer | Feb 21, 2025 | Feb 25, 2025 | A · derivative | 7,816 | $137.75 | $1,076,654 | 7,816 | No | Form 4 |
| Maizel AriChief Commercial Officer | Feb 21, 2025 | Feb 25, 2025 | A · derivative | 7,740 | $0.00 | $0 | 7,740 | No | Form 4 |
| Saad Mark E | Feb 21, 2025 | Feb 25, 2025 | A · derivative | 1,494 | $137.75 | $205,799 | 1,494 | No | Form 4 |
| Jeffs Roger | Feb 21, 2025 | Feb 25, 2025 | A · derivative | 1,408 | $137.75 | $193,952 | 1,408 | No | Form 4 |
| Mahony Susan | Feb 21, 2025 | Feb 25, 2025 | A · derivative | 1,312 | $137.75 | $180,728 | 1,312 | No | Form 4 |
| Pizzie NickChief Financial Officer | Feb 14, 2025 | Feb 14, 2025 | M | 3,000 | $3.50 | $10,500 | 45,187 | Yes | Form 4 |
| Pizzie NickChief Financial Officer | Feb 14, 2025 | Feb 14, 2025 | S | 3,000 | $131.07 | Sale −$393,210 | 42,187 | Yes | Form 4 |
| Pizzie NickChief Financial Officer | Feb 14, 2025 | Feb 14, 2025 | M · derivative | 3,000 | $3.50 | $10,500 | not reported | Yes | Form 4 |
| Pizzie NickChief Financial Officer | Feb 13, 2025 | Feb 14, 2025 | M | 12,000 | $3.50 | $42,000 | 54,187 | Yes | Form 4 |
| Pizzie NickChief Financial Officer | Feb 13, 2025 | Feb 14, 2025 | S | 12,000 | $129.86 | Sale −$1,558,320 | 42,187 | Yes | Form 4 |
| Pizzie NickChief Financial Officer | Feb 13, 2025 | Feb 14, 2025 | M · derivative | 12,000 | $3.50 | $42,000 | not reported | Yes | Form 4 |
| Coleman Mark | Jan 3, 2025 | Jan 6, 2025 | M | 9,127 | $9.00 | $82,143 | 57,137 | No | Form 4 |
| Coleman Mark | Jan 3, 2025 | Jan 6, 2025 | M · derivative | 9,127 | $9.00 | $82,143 | not reported | No | Form 4 |
| Coleman Mark | Nov 19, 2024 | Nov 20, 2024 | M | 33,410 | $5.94 | $198,455 | 48,010 | No | Form 4 |
| Coleman Mark | Nov 19, 2024 | Nov 20, 2024 | M · derivative | 33,410 | $5.94 | $198,455 | not reported | No | Form 4 |
| Saad Mark E | Sep 11, 2024 | Sep 11, 2024 | M | 11,016 | $3.67 | $40,429 | 21,018 | Yes | Form 4 |
| Saad Mark E | Sep 11, 2024 | Sep 11, 2024 | S | 11,016 | $91.31 | Sale −$1,005,871 | 10,002 | Yes | Form 4 |
| Saad Mark E | Sep 11, 2024 | Sep 11, 2024 | M · derivative | 11,016 | $3.67 | $40,429 | not reported | Yes | Form 4 |
| Jacobson Mark L.Chief Operating Officer | Aug 9, 2024 | Aug 9, 2024 | M | 47,739 | $4.04 | $192,866 | 53,522 | Yes | Form 4 |
| Jacobson Mark L.Chief Operating Officer | Aug 9, 2024 | Aug 9, 2024 | S | 47,739 | $84.26 | Sale −$4,022,488 | 5,783 | Yes | Form 4 |
| Jacobson Mark L.Chief Operating Officer | Aug 9, 2024 | Aug 9, 2024 | M · derivative | 47,739 | $4.04 | $192,866 | not reported | Yes | Form 4 |
| Saad Mark E | Jun 7, 2024 | Jun 11, 2024 | A · derivative | 5,799 | $73.90 | $428,546 | 5,799 | No | Form 4 |
| Jeffs Roger | Jun 7, 2024 | Jun 11, 2024 | A · derivative | 5,799 | $73.90 | $428,546 | 5,799 | No | Form 4 |
| Coleman Mark | Jun 7, 2024 | Jun 11, 2024 | A · derivative | 5,799 | $73.90 | $428,546 | 5,799 | No | Form 4 |
| Mahony Susan | Jun 7, 2024 | Jun 11, 2024 | A · derivative | 5,799 | $73.90 | $428,546 | 5,799 | No | Form 4 |
| Coleman Mark | May 29, 2024 | May 29, 2024 | S | 5,248 | $75.14 | Sale −$394,335 | 14,600 | Yes | Form 4 |
| Jacobson Mark L.Chief Operating Officer | May 29, 2024 | May 29, 2024 | M | 13,693 | $1.30 | $17,801 | 13,693 | No | Form 4 |
| Jacobson Mark L.Chief Operating Officer | May 29, 2024 | May 29, 2024 | S | 7,910 | $74.31 | Sale −$587,792 | 5,783 | No | Form 4 |
| Jacobson Mark L.Chief Operating Officer | May 29, 2024 | May 29, 2024 | M · derivative | 13,693 | $1.30 | $17,801 | not reported | No | Form 4 |
| Coleman Mark | May 28, 2024 | May 29, 2024 | S | 5,249 | $75.21 | Sale −$394,777 | 19,848 | Yes | Form 4 |
| Jacobson Mark L.Chief Operating Officer | Apr 1, 2024 | Apr 1, 2024 | M | 24,662 | $1.30 | $32,061 | 24,662 | Yes | Form 4 |
| Jacobson Mark L.Chief Operating Officer | Apr 1, 2024 | Apr 1, 2024 | S | 24,662 | $77.24 | Sale −$1,904,893 | not reported | Yes | Form 4 |
| Jacobson Mark L.Chief Operating Officer | Apr 1, 2024 | Apr 1, 2024 | M · derivative | 24,662 | $1.30 | $32,061 | not reported | Yes | Form 4 |
| Jeffs Roger | Mar 15, 2024 | Mar 15, 2024 | M | 2,347 | $29.91 | $70,199 | 123,103 | Yes | Form 4 |
| Jeffs Roger | Mar 15, 2024 | Mar 15, 2024 | S | 2,347 | $71.61 | Sale −$168,069 | 120,756 | Yes | Form 4 |
| Jeffs Roger | Mar 15, 2024 | Mar 15, 2024 | M · derivative | 2,347 | $29.91 | $70,199 | not reported | Yes | Form 4 |
| Jeffs Roger | Mar 14, 2024 | Mar 15, 2024 | M | 13,000 | $22.03 | $286,390 | 133,756 | Yes | Form 4 |
| Jeffs Roger | Mar 14, 2024 | Mar 15, 2024 | S | 13,000 | $69.70 | Sale −$906,100 | 120,756 | Yes | Form 4 |
| Jeffs Roger | Mar 14, 2024 | Mar 15, 2024 | M | 16,976 | $25.53 | $433,397 | 137,732 | Yes | Form 4 |
| Jeffs Roger | Mar 14, 2024 | Mar 15, 2024 | S | 16,976 | $69.70 | Sale −$1,183,227 | 120,756 | Yes | Form 4 |
| Jeffs Roger | Mar 14, 2024 | Mar 15, 2024 | M · derivative | 13,000 | $22.03 | $286,390 | not reported | Yes | Form 4 |
| Jeffs Roger | Mar 14, 2024 | Mar 15, 2024 | M · derivative | 16,976 | $25.53 | $433,397 | not reported | Yes | Form 4 |
| Murdock Hunter R.General Counsel | Feb 27, 2024 | Feb 29, 2024 | A · derivative | 23,593 | $84.00 | $1,981,812 | 23,593 | No | Form 4 |
| Murdock Hunter R.General Counsel | Feb 27, 2024 | Feb 29, 2024 | A · derivative | 12,956 | $0.00 | $0 | 12,956 | No | Form 4 |
| Mahony Susan | Feb 27, 2024 | Feb 29, 2024 | A · derivative | 191 | $84.00 | $16,044 | 191 | No | Form 4 |
| Tabuteau HerriotCHIEF EXECUTIVE OFFICER | Feb 27, 2024 | Feb 29, 2024 | A · derivative | 87,192 | $84.00 | $7,324,128 | 87,192 | No | Form 4 |
| Tabuteau HerriotCHIEF EXECUTIVE OFFICER | Feb 27, 2024 | Feb 29, 2024 | A · derivative | 47,886 | $0.00 | $0 | 47,886 | No | Form 4 |
| Pizzie NickCHIEF FINANCIAL OFFICER | Feb 27, 2024 | Feb 29, 2024 | A · derivative | 28,722 | $84.00 | $2,412,648 | 28,722 | No | Form 4 |
| Pizzie NickCHIEF FINANCIAL OFFICER | Feb 27, 2024 | Feb 29, 2024 | A · derivative | 15,774 | $0.00 | $0 | 15,774 | No | Form 4 |
| Jacobson Mark L.CHIEF OPERATING OFFICER | Feb 27, 2024 | Feb 29, 2024 | A · derivative | 32,825 | $84.00 | $2,757,300 | 32,825 | No | Form 4 |
| Jacobson Mark L.CHIEF OPERATING OFFICER | Feb 27, 2024 | Feb 29, 2024 | A · derivative | 18,027 | $0.00 | $0 | 18,027 | No | Form 4 |
| Saad Mark E | Feb 27, 2024 | Feb 29, 2024 | A · derivative | 1,519 | $84.00 | $127,596 | 1,519 | No | Form 4 |
| Jeffs Roger | Feb 27, 2024 | Feb 29, 2024 | A · derivative | 1,425 | $84.00 | $119,700 | 1,425 | No | Form 4 |
| Mahony Susan | Oct 10, 2023 | Oct 12, 2023 | A · derivative | 1,502 | $70.56 | $105,981 | 1,502 | No | Form 4 |
| Mahony Susan | Oct 10, 2023 | Oct 12, 2023 | A · derivative | 5,873 | $70.56 | $414,399 | 5,873 | No | Form 4 |