BMRNBIOMARIN PHARMACEUTICAL INC
- Market cap
- $10.83B
- as of 2026-10-23
- Latest close
- $55.95
- as of 2026-10-23
- Sector
- Healthcare
- as of 2026-10-24
- Industry
- Biotechnology
- as of 2026-10-24
Cluster
No cluster in the last 90 days under the default rule (14d · ≥2 insiders · all roles).
Form 4 historysince 2023-12-05
| Insider | Traded | Filed | Type | Shares | Price | Value | Owned after | 10b5-1 plan | Filing |
|---|---|---|---|---|---|---|---|---|---|
| Friberg Gregory REVP, Chief R&D Officer | Sep 30 | Oct 1 | F | 4,086 | $60.00 | $245,160 | 47,732 | No | Form 4 |
| Plenge Robert M | Sep 10 | Sep 14 | A | 6,140 | $0.00 | $0 | 6,140 | No | Form 4 |
| Davis George EricEVP, Chief Legal Officer | Sep 2 | Sep 3 | S | 17,557 | $66.28 | Sale −$1,163,678 | 61,003 | No | Form 4 |
| Anderson Elizabeth M | Jun 2 | Jun 4 | A | 7,490 | $0.00 | $0 | 41,940 | No | Form 4 |
| Bodem Barbara W. | Jun 2 | Jun 4 | A | 7,490 | $0.00 | $0 | 21,045 | No | Form 4 |
| Clark Ian T | Jun 2 | Jun 4 | A | 7,490 | $0.00 | $0 | 14,490 | No | Form 4 |
| Dere Willard H | Jun 2 | Jun 4 | A | 7,490 | $0.00 | $0 | 46,440 | No | Form 4 |
| Enyedy Mark J | Jun 2 | Jun 4 | A | 7,490 | $0.00 | $0 | 21,040 | No | Form 4 |
| Hombach Robert J. | Jun 2 | Jun 4 | A | 7,490 | $0.00 | $0 | 49,360 | No | Form 4 |
| Ho Maykin | Jun 2 | Jun 4 | A | 7,490 | $0.00 | $0 | 35,500 | No | Form 4 |
| Walbert Timothy P | Jun 2 | Jun 4 | A | 7,490 | $0.00 | $0 | 17,270 | No | Form 4 |
| Countouriotis Athena | Jun 2 | Jun 4 | A | 7,490 | $0.00 | $0 | 21,040 | No | Form 4 |
| Hubbard CristinEVP, Chief Commercial Officer | May 20 | May 21 | F | 2,318 | $50.20 | $116,364 | 42,472 | No | Form 4 |
| Friberg Gregory REVP, Chief R&D Officer | May 7 | May 11 | S | 3,281 | $53.85 | Sale −$176,682 | 51,818 | No | Form 4 |
| Davis George EricEVP, Chief Legal Officer | Mar 18 | Mar 19 | F | 1,273 | $56.05 | $71,352 | 78,560 | No | Form 4 |
| Hardy AlexanderChief Executive Officer | Mar 17 | Mar 19 | F | 4,252 | $56.05 | $238,325 | 214,635 | No | Form 4 |
| Mueller BrianEVP, Chief Financial Officer | Mar 17 | Mar 19 | F | 2,117 | $56.05 | $118,658 | 123,314 | No | Form 4 |
| Guyer Charles GregEVP, Chief Technical Officer | Mar 17 | Mar 19 | F | 1,693 | $56.05 | $94,893 | 84,140 | No | Form 4 |
| Friberg Gregory REVP, Chief R&D Officer | Mar 17 | Mar 18 | F | 1,629 | $56.05 | $91,305 | 55,099 | No | Form 4 |
| Hubbard CristinEVP, Chief Commercial Officer | Mar 17 | Mar 18 | F | 1,245 | $56.05 | $69,782 | 44,790 | No | Form 4 |
| Friberg Gregory REVP, Chief R&D Officer | Mar 16 | Mar 18 | A | 19,150 | $0.00 | $0 | 56,728 | No | Form 4 |
| Friberg Gregory REVP, Chief R&D Officer | Mar 16 | Mar 18 | A · derivative | 45,600 | $57.43 | $2,618,808 | 45,600 | No | Form 4 |
| Hubbard CristinEVP, Chief Commercial Officer | Mar 16 | Mar 18 | A | 15,410 | $0.00 | $0 | 46,035 | No | Form 4 |
| Hubbard CristinEVP, Chief Commercial Officer | Mar 16 | Mar 18 | A · derivative | 36,680 | $57.43 | $2,106,532 | 36,680 | No | Form 4 |
| Hardy AlexanderChief Executive Officer | Mar 16 | Mar 17 | A | 62,440 | $0.00 | $0 | 218,887 | No | Form 4 |
| Hardy AlexanderChief Executive Officer | Mar 16 | Mar 17 | A · derivative | 89,200 | $57.43 | $5,122,756 | 89,200 | No | Form 4 |
| Mueller BrianEVP, Chief Financial Officer | Mar 16 | Mar 17 | A | 18,740 | $0.00 | $0 | 125,431 | No | Form 4 |
| Mueller BrianEVP, Chief Financial Officer | Mar 16 | Mar 17 | A · derivative | 44,600 | $57.43 | $2,561,378 | 44,600 | No | Form 4 |
| Davis George EricEVP, Chief Legal Officer | Mar 16 | Mar 17 | F | 7,177 | $58.51 | $419,926 | 65,263 | No | Form 4 |
| Davis George EricEVP, Chief Legal Officer | Mar 16 | Mar 17 | A | 14,570 | $0.00 | $0 | 79,833 | No | Form 4 |
| Davis George EricEVP, Chief Legal Officer | Mar 16 | Mar 17 | A · derivative | 34,690 | $57.43 | $1,992,247 | 34,690 | No | Form 4 |
| Guyer Charles GregEVP, Chief Technical Officer | Mar 16 | Mar 17 | A | 14,990 | $0.00 | $0 | 85,833 | No | Form 4 |
| Guyer Charles GregEVP, Chief Technical Officer | Mar 16 | Mar 17 | A · derivative | 35,680 | $57.43 | $2,049,102 | 35,680 | No | Form 4 |
| Hardy AlexanderChief Executive Officer | Mar 13 | Mar 17 | F | 2,941 | $58.51 | $172,078 | 156,447 | No | Form 4 |
| Mueller BrianEVP, Chief Financial Officer | Mar 13 | Mar 17 | F | 9,945 | $58.51 | $581,882 | 106,691 | No | Form 4 |
| Guyer Charles GregEVP, Chief Technical Officer | Mar 13 | Mar 17 | F | 9,109 | $58.51 | $532,968 | 70,843 | No | Form 4 |
| Guyer Charles GregEVP, Chief Technical Officer | Mar 11 | Mar 12 | S | 16,486 | $60.46 | Sale −$996,744 | 79,953 | No | Form 4 |
| Davis George EricEVP, Chief Legal Officer | Feb 26 | Feb 26 | S | 26,061 | $61.36 | Sale −$1,599,103 | 72,453 | No | Form 4 |
| Friberg Gregory REVP, Chief R&D Officer | Feb 26 | Feb 26 | S | 6,326 | $60.38 | Sale −$381,964 | 37,578 | No | Form 4 |
| Mueller BrianEVP, Chief Financial Officer | Feb 25 | Feb 26 | A | 6,683 | $0.00 | $0 | 106,839 | No | Form 4 |
| Mueller BrianEVP, Chief Financial Officer | Feb 25 | Feb 26 | A | 7,230 | $0.00 | $0 | 114,069 | No | Form 4 |
| Mueller BrianEVP, Chief Financial Officer | Feb 25 | Feb 26 | A | 2,569 | $0.00 | $0 | 116,638 | No | Form 4 |
| Davis George EricEVP, Chief Legal Officer | Feb 25 | Feb 26 | A | 6,177 | $0.00 | $0 | 89,467 | No | Form 4 |
| Davis George EricEVP, Chief Legal Officer | Feb 25 | Feb 26 | A | 6,675 | $0.00 | $0 | 96,142 | No | Form 4 |
| Davis George EricEVP, Chief Legal Officer | Feb 25 | Feb 26 | A | 2,372 | $0.00 | $0 | 98,514 | No | Form 4 |
| Guyer Charles GregEVP, Chief Technical Officer | Feb 25 | Feb 26 | A | 6,176 | $0.00 | $0 | 87,393 | No | Form 4 |
| Guyer Charles GregEVP, Chief Technical Officer | Feb 25 | Feb 26 | A | 6,675 | $0.00 | $0 | 94,068 | No | Form 4 |
| Guyer Charles GregEVP, Chief Technical Officer | Feb 25 | Feb 26 | A | 2,371 | $0.00 | $0 | 96,439 | No | Form 4 |
| Ramchandani Rashmi VirendraVP, Chief Accounting Officer | Jan 20 | Jan 22 | A | 18,540 | $0.00 | $0 | 18,540 | No | Form 4 |
| Ramchandani Rashmi VirendraVP, Chief Accounting Officer | Jan 20 | Jan 22 | A | 7,070 | $0.00 | $0 | 25,610 | No | Form 4 |
| Ramchandani Rashmi VirendraVP, Chief Accounting Officer | Jan 20 | Jan 22 | A · derivative | 18,220 | $56.31 | $1,025,968 | 18,220 | No | Form 4 |
| Hardy AlexanderChief Executive Officer | Dec 1, 2025 | Dec 2, 2025 | F | 16,570 | $55.03 | $911,847 | 159,388 | No | Form 4 |
| Hardy AlexanderChief Executive Officer | Apr 30, 2025 | Dec 2, 2025 | A | 375 | $54.14 | $20,303 | 175,958 | No | Form 4 |
| Friberg Gregory REVP, Chief R&D Officer | Sep 30, 2025 | Oct 2, 2025 | F | 3,304 | $54.16 | $178,945 | 43,506 | No | Form 4 |
| Clark Ian T | Aug 1, 2025 | Aug 5, 2025 | A | 7,000 | $0.00 | $0 | 7,000 | No | Form 4 |
| Anderson Elizabeth M | May 20, 2025 | May 22, 2025 | A | 6,650 | $0.00 | $0 | 34,450 | No | Form 4 |
| Bodem Barbara W. | May 20, 2025 | May 22, 2025 | A | 6,650 | $0.00 | $0 | 13,555 | No | Form 4 |
| Countouriotis Athena | May 20, 2025 | May 22, 2025 | A | 6,650 | $0.00 | $0 | 13,550 | No | Form 4 |
| Dere Willard H | May 20, 2025 | May 22, 2025 | A | 6,650 | $0.00 | $0 | 38,950 | No | Form 4 |
| Enyedy Mark J | May 20, 2025 | May 22, 2025 | A | 6,650 | $0.00 | $0 | 13,550 | No | Form 4 |
| Ho Maykin | May 20, 2025 | May 22, 2025 | A | 6,650 | $0.00 | $0 | 28,010 | No | Form 4 |
| Hombach Robert J. | May 20, 2025 | May 22, 2025 | A | 6,650 | $0.00 | $0 | 41,870 | No | Form 4 |
| Meier Richard A | May 20, 2025 | May 22, 2025 | A | 6,650 | $0.00 | $0 | 127,426 | No | Form 4 |
| Walbert Timothy P | May 20, 2025 | May 22, 2025 | A | 6,650 | $0.00 | $0 | 9,780 | No | Form 4 |
| Hubbard CristinEVP, Chief Commercial Officer | May 20, 2025 | May 22, 2025 | F | 2,155 | $59.93 | $129,149 | 30,545 | No | Form 4 |
| Burkhart ErinGVP, Chief Accounting Officer | May 20, 2025 | May 20, 2025 | S | 1,786 | $59.31 | Sale −$105,928 | 14,173 | Yes | Form 4 |
| Burkhart ErinGVP, Chief Accounting Officer | May 19, 2025 | May 20, 2025 | F | 996 | $59.27 | $59,033 | 15,959 | Yes | Form 4 |
| Hubbard CristinEVP, Chief Commercial Officer | May 2, 2025 | May 6, 2025 | S | 273 | $64.92 | Sale −$17,723 | 32,700 | Yes | Form 4 |
| Hubbard CristinEVP, Chief Commercial Officer | Apr 30, 2025 | May 6, 2025 | A | 273 | $54.14 | $14,780 | 32,973 | Yes | Form 4 |
| Burkhart ErinGVP, Chief Accounting Officer | Mar 19, 2025 | Mar 20, 2025 | S | 1,295 | $71.52 | Sale −$92,618 | 16,955 | Yes | Form 4 |
| Hardy AlexanderChief Executive Officer | Mar 17, 2025 | Mar 18, 2025 | A | 44,360 | $0.00 | $0 | 175,583 | No | Form 4 |
| Hardy AlexanderChief Executive Officer | Mar 17, 2025 | Mar 18, 2025 | A · derivative | 61,750 | $71.55 | $4,418,213 | 61,750 | No | Form 4 |
| Mueller BrianEVP, Chief Financial Officer | Mar 17, 2025 | Mar 18, 2025 | A | 16,640 | $0.00 | $0 | 99,781 | No | Form 4 |
| Mueller BrianEVP, Chief Financial Officer | Mar 17, 2025 | Mar 18, 2025 | A · derivative | 38,590 | $71.55 | $2,761,115 | 38,590 | No | Form 4 |
| Guyer Charles GregEVP, Chief Technical Officer | Mar 17, 2025 | Mar 18, 2025 | A | 13,310 | $0.00 | $0 | 80,838 | No | Form 4 |
| Guyer Charles GregEVP, Chief Technical Officer | Mar 17, 2025 | Mar 18, 2025 | A · derivative | 30,880 | $71.55 | $2,209,464 | 30,880 | No | Form 4 |
| Friberg Gregory REVP, Chief R&D Officer | Mar 17, 2025 | Mar 18, 2025 | A | 17,750 | $0.00 | $0 | 46,810 | No | Form 4 |
| Friberg Gregory REVP, Chief R&D Officer | Mar 17, 2025 | Mar 18, 2025 | A · derivative | 41,170 | $71.55 | $2,945,714 | 41,170 | No | Form 4 |
| Hubbard CristinEVP, Chief Commercial Officer | Mar 17, 2025 | Mar 18, 2025 | A | 13,310 | $0.00 | $0 | 32,700 | No | Form 4 |
| Hubbard CristinEVP, Chief Commercial Officer | Mar 17, 2025 | Mar 18, 2025 | A · derivative | 30,880 | $71.55 | $2,209,464 | 30,880 | No | Form 4 |
| Davis George EricEVP, Chief Legal Officer | Mar 17, 2025 | Mar 18, 2025 | A | 12,940 | $0.00 | $0 | 82,915 | No | Form 4 |
| Davis George EricEVP, Chief Legal Officer | Mar 17, 2025 | Mar 18, 2025 | A · derivative | 30,020 | $71.55 | $2,147,931 | 30,020 | No | Form 4 |
| Burkhart ErinGVP, Chief Accounting Officer | Mar 17, 2025 | Mar 18, 2025 | A | 5,970 | $0.00 | $0 | 18,252 | No | Form 4 |
| Burkhart ErinGVP, Chief Accounting Officer | Mar 17, 2025 | Mar 18, 2025 | A · derivative | 9,230 | $71.55 | $660,407 | 9,230 | No | Form 4 |
| Hardy AlexanderChief Executive Officer | Mar 14, 2025 | Mar 18, 2025 | F | 2,933 | $69.44 | $203,668 | 131,223 | No | Form 4 |
| Mueller BrianEVP, Chief Financial Officer | Mar 14, 2025 | Mar 18, 2025 | F | 18,497 | $69.44 | $1,284,432 | 83,141 | No | Form 4 |
| Guyer Charles GregEVP, Chief Technical Officer | Mar 14, 2025 | Mar 18, 2025 | F | 20,127 | $69.44 | $1,397,619 | 67,528 | No | Form 4 |
| Davis George EricEVP, Chief Legal Officer | Mar 14, 2025 | Mar 18, 2025 | F | 16,249 | $69.44 | $1,128,331 | 69,975 | No | Form 4 |
| Burkhart ErinGVP, Chief Accounting Officer | Mar 14, 2025 | Mar 18, 2025 | F | 823 | $69.44 | $57,149 | 12,282 | No | Form 4 |
| Guyer Charles GregEVP, Chief Technical Officer | Mar 6, 2025 | Mar 7, 2025 | S | 7,034 | $71.28 | Sale −$501,384 | 87,655 | No | Form 4 |
| Guyer Charles GregEVP, Chief Technical Officer | Feb 28, 2025 | Mar 4, 2025 | F | 4,287 | $71.16 | $305,063 | 94,689 | No | Form 4 |
| Davis George EricEVP, Chief Legal Officer | Feb 25, 2025 | Feb 27, 2025 | A | 11,040 | $0.00 | $0 | 67,197 | No | Form 4 |
| Davis George EricEVP, Chief Legal Officer | Feb 25, 2025 | Feb 27, 2025 | A | 9,660 | $0.00 | $0 | 76,857 | No | Form 4 |
| Davis George EricEVP, Chief Legal Officer | Feb 25, 2025 | Feb 27, 2025 | A | 9,367 | $0.00 | $0 | 86,224 | No | Form 4 |
| Guyer Charles GregEVP, Chief Technical Officer | Feb 25, 2025 | Feb 27, 2025 | A | 11,040 | $0.00 | $0 | 79,949 | No | Form 4 |
| Guyer Charles GregEVP, Chief Technical Officer | Feb 25, 2025 | Feb 27, 2025 | A | 9,660 | $0.00 | $0 | 89,609 | No | Form 4 |
| Guyer Charles GregEVP, Chief Technical Officer | Feb 25, 2025 | Feb 27, 2025 | A | 9,367 | $0.00 | $0 | 98,976 | No | Form 4 |
| Mueller BrianEVP, Chief Financial Officer | Feb 25, 2025 | Feb 27, 2025 | A | 11,040 | $0.00 | $0 | 82,611 | No | Form 4 |
| Mueller BrianEVP, Chief Financial Officer | Feb 25, 2025 | Feb 27, 2025 | A | 9,660 | $0.00 | $0 | 92,271 | No | Form 4 |
| Mueller BrianEVP, Chief Financial Officer | Feb 25, 2025 | Feb 27, 2025 | A | 9,367 | $0.00 | $0 | 101,638 | No | Form 4 |
| Walbert Timothy P | Feb 24, 2025 | Feb 26, 2025 | A | 3,130 | $0.00 | $0 | 3,130 | No | Form 4 |
| Burkhart ErinGVP, Chief Accounting Officer | Feb 24, 2025 | Feb 25, 2025 | S | 1,344 | $68.38 | Sale −$91,903 | 13,105 | Yes | Form 4 |
| Hardy AlexanderChief Executive Officer | Nov 29, 2024 | Dec 3, 2024 | F | 14,295 | $66.03 | $943,899 | 134,156 | No | Form 4 |
| Hardy AlexanderChief Executive Officer | Oct 31, 2024 | Dec 3, 2024 | A | 300 | $56.01 | $16,803 | 148,451 | No | Form 4 |
| Guyer Charles GregEVP, Chief Technical Officer | Nov 12, 2024 | Nov 14, 2024 | S | 5,278 | $66.37 | Sale −$350,301 | 68,909 | No | Form 4 |
| Guyer Charles GregEVP, Chief Technical Officer | Oct 31, 2024 | Nov 14, 2024 | A | 55 | $56.01 | $3,081 | 74,187 | No | Form 4 |
| Friberg Gregory REVP, Chief R&D Officer | Sep 30, 2024 | Oct 1, 2024 | A | 21,190 | $0.00 | $0 | 21,190 | No | Form 4 |
| Friberg Gregory REVP, Chief R&D Officer | Sep 30, 2024 | Oct 1, 2024 | A | 7,870 | $0.00 | $0 | 29,060 | No | Form 4 |
| Friberg Gregory REVP, Chief R&D Officer | Sep 30, 2024 | Oct 1, 2024 | A · derivative | 49,850 | $70.29 | $3,503,957 | 49,850 | No | Form 4 |
| Fuchs Henry JPresident, Worldwide R&D | Sep 13, 2024 | Sep 17, 2024 | F | 12,098 | $84.90 | $1,027,120 | 185,074 | No | Form 4 |
| Fuchs Henry JPresident, Worldwide R&D | Apr 30, 2024 | Sep 17, 2024 | A | 300 | $68.65 | $20,595 | 197,172 | No | Form 4 |
| Burkhart ErinGVP, Chief Accounting Officer | Aug 13, 2024 | Aug 15, 2024 | S | 714 | $90.00 | Sale −$64,260 | 14,449 | Yes | Form 4 |
| Mueller BrianEVP, Chief Financial Officer | Jun 28, 2024 | Jul 1, 2024 | F | 588 | $82.33 | $48,410 | 71,571 | No | Form 4 |
| Meier Richard A | Jun 3, 2024 | Jun 4, 2024 | M | 6,600 | $63.10 | $416,460 | 126,227 | No | Form 4 |
| Meier Richard A | Jun 3, 2024 | Jun 4, 2024 | F | 5,451 | $76.41 | $416,511 | 120,776 | No | Form 4 |
| Meier Richard A | Jun 3, 2024 | Jun 4, 2024 | M · derivative | 6,600 | $63.10 | $416,460 | not reported | No | Form 4 |
| Heron Elaine J | Jun 3, 2024 | Jun 4, 2024 | M | 5,047 | $63.10 | $318,466 | 101,888 | No | Form 4 |
| Heron Elaine J | Jun 3, 2024 | Jun 4, 2024 | F | 4,168 | $76.41 | $318,477 | 97,720 | No | Form 4 |
| Heron Elaine J | Jun 3, 2024 | Jun 4, 2024 | M · derivative | 5,047 | $63.10 | $318,466 | not reported | No | Form 4 |
| Mueller BrianEVP, Chief Financial Officer | May 30, 2024 | May 31, 2024 | M | 5,000 | $63.10 | $315,500 | 77,159 | Yes | Form 4 |
| Mueller BrianEVP, Chief Financial Officer | May 30, 2024 | May 31, 2024 | S | 5,000 | $75.19 | Sale −$375,950 | 72,159 | Yes | Form 4 |
| Mueller BrianEVP, Chief Financial Officer | May 30, 2024 | May 31, 2024 | M · derivative | 5,000 | $63.10 | $315,500 | not reported | Yes | Form 4 |
| Mueller BrianEVP, Chief Financial Officer | Apr 30, 2024 | May 31, 2024 | A | 300 | $68.65 | $20,595 | 72,159 | Yes | Form 4 |
| Davis George EricEVP, Chief Legal Officer | May 28, 2024 | May 30, 2024 | M | 40,850 | $63.10 | $2,577,635 | 97,007 | Yes | Form 4 |
| Davis George EricEVP, Chief Legal Officer | May 28, 2024 | May 30, 2024 | S | 38,071 | $74.46 | Sale −$2,834,767 | 58,936 | Yes | Form 4 |
| Davis George EricEVP, Chief Legal Officer | May 28, 2024 | May 30, 2024 | S | 2,779 | $75.29 | Sale −$209,231 | 56,157 | Yes | Form 4 |
| Davis George EricEVP, Chief Legal Officer | May 28, 2024 | May 30, 2024 | M · derivative | 40,850 | $63.10 | $2,577,635 | not reported | Yes | Form 4 |
| Anderson Elizabeth M | May 21, 2024 | May 23, 2024 | A | 4,720 | $0.00 | $0 | 27,800 | No | Form 4 |
| Bodem Barbara W. | May 21, 2024 | May 23, 2024 | A | 4,720 | $0.00 | $0 | 6,900 | No | Form 4 |
| Countouriotis Athena | May 21, 2024 | May 23, 2024 | A | 4,720 | $0.00 | $0 | 6,900 | No | Form 4 |
| Dere Willard H | May 21, 2024 | May 23, 2024 | A | 4,720 | $0.00 | $0 | 32,300 | No | Form 4 |
| Enyedy Mark J | May 21, 2024 | May 23, 2024 | A | 4,720 | $0.00 | $0 | 6,900 | No | Form 4 |
| Heron Elaine J | May 21, 2024 | May 23, 2024 | A | 4,720 | $0.00 | $0 | 96,841 | No | Form 4 |
| Ho Maykin | May 21, 2024 | May 23, 2024 | A | 4,720 | $0.00 | $0 | 21,360 | No | Form 4 |
| Hombach Robert J. | May 21, 2024 | May 23, 2024 | A | 4,720 | $0.00 | $0 | 35,220 | No | Form 4 |
| Meier Richard A | May 21, 2024 | May 23, 2024 | A | 7,080 | $0.00 | $0 | 119,627 | No | Form 4 |
| Pyott David E I | May 21, 2024 | May 23, 2024 | A | 4,720 | $0.00 | $0 | 49,750 | No | Form 4 |
| Hubbard CristinEVP, Chief Commercial Officer | May 20, 2024 | May 22, 2024 | A | 14,690 | $0.00 | $0 | 14,690 | No | Form 4 |
| Hubbard CristinEVP, Chief Commercial Officer | May 20, 2024 | May 22, 2024 | A | 4,700 | $0.00 | $0 | 19,390 | No | Form 4 |
| Hubbard CristinEVP, Chief Commercial Officer | May 20, 2024 | May 22, 2024 | A · derivative | 33,520 | $77.05 | $2,582,716 | 33,520 | No | Form 4 |
| Bienaime Jean Jacques | May 20, 2024 | May 21, 2024 | F | 1,202 | $77.05 | $92,614 | 473,792 | No | Form 4 |
| Burkhart ErinGVP, Chief Accounting Officer | May 17, 2024 | May 20, 2024 | F | 993 | $76.97 | $76,431 | 15,163 | No | Form 4 |
| Bienaime Jean Jacques | May 10, 2024 | May 13, 2024 | M | 20,000 | $63.10 | $1,262,000 | 494,994 | Yes | Form 4 |
| Bienaime Jean Jacques | May 10, 2024 | May 13, 2024 | S | 20,000 | $81.14 | Sale −$1,622,800 | 474,994 | Yes | Form 4 |
| Bienaime Jean Jacques | May 10, 2024 | May 13, 2024 | M · derivative | 20,000 | $63.10 | $1,262,000 | 51,000 | Yes | Form 4 |
| Bienaime Jean Jacques | May 9, 2024 | May 13, 2024 | M | 20,000 | $63.10 | $1,262,000 | 494,994 | Yes | Form 4 |
| Bienaime Jean Jacques | May 9, 2024 | May 13, 2024 | S | 20,000 | $81.62 | Sale −$1,632,400 | 474,994 | Yes | Form 4 |
| Bienaime Jean Jacques | May 9, 2024 | May 13, 2024 | M · derivative | 20,000 | $63.10 | $1,262,000 | 71,000 | Yes | Form 4 |
| Guyer Charles GregEVP, Chief Technical Officer | May 3, 2024 | May 7, 2024 | F | 4,440 | $82.44 | $366,034 | 74,132 | No | Form 4 |
| Guyer Charles GregEVP, Chief Technical Officer | Apr 30, 2024 | May 7, 2024 | A | 245 | $68.65 | $16,819 | 78,572 | No | Form 4 |
| Ajer Jeffrey RobertEVP, Chief Commercial Officer | May 2, 2024 | May 6, 2024 | S | 5,000 | $82.91 | Sale −$414,550 | 66,767 | Yes | Form 4 |
| Davis George EricEVP, Chief Legal Officer | May 2, 2024 | May 6, 2024 | M | 1,850 | $63.10 | $116,735 | 58,007 | Yes | Form 4 |
| Davis George EricEVP, Chief Legal Officer | May 2, 2024 | May 6, 2024 | S | 1,850 | $85.01 | Sale −$157,269 | 56,157 | Yes | Form 4 |
| Davis George EricEVP, Chief Legal Officer | May 2, 2024 | May 6, 2024 | M · derivative | 1,850 | $63.10 | $116,735 | 40,850 | Yes | Form 4 |
| Ajer Jeffrey RobertEVP, Chief Commercial Officer | Apr 30, 2024 | May 6, 2024 | A | 300 | $68.65 | $20,595 | 71,767 | Yes | Form 4 |
| Davis George EricEVP, Chief Legal Officer | Apr 30, 2024 | May 6, 2024 | A | 301 | $68.65 | $20,664 | 56,157 | Yes | Form 4 |
| Bienaime Jean Jacques | Apr 12, 2024 | Apr 15, 2024 | M | 20,000 | $63.10 | $1,262,000 | 494,994 | Yes | Form 4 |
| Bienaime Jean Jacques | Apr 12, 2024 | Apr 15, 2024 | S | 20,000 | $91.26 | Sale −$1,825,200 | 474,994 | Yes | Form 4 |
| Bienaime Jean Jacques | Apr 12, 2024 | Apr 15, 2024 | M · derivative | 20,000 | $63.10 | $1,262,000 | 91,000 | Yes | Form 4 |
| Bienaime Jean Jacques | Apr 11, 2024 | Apr 15, 2024 | M | 20,000 | $63.10 | $1,262,000 | 494,994 | Yes | Form 4 |
| Bienaime Jean Jacques | Apr 11, 2024 | Apr 15, 2024 | S | 20,000 | $90.99 | Sale −$1,819,800 | 474,994 | Yes | Form 4 |
| Bienaime Jean Jacques | Apr 11, 2024 | Apr 15, 2024 | M · derivative | 20,000 | $63.10 | $1,262,000 | 111,000 | Yes | Form 4 |
| Burkhart ErinGVP, Chief Accounting Officer | Apr 10, 2024 | Apr 12, 2024 | S | 2,286 | $90.00 | Sale −$205,740 | 16,156 | Yes | Form 4 |
| Davis George EricEVP, Chief Legal Officer | Mar 28, 2024 | Apr 1, 2024 | S | 24,602 | $88.34 | Sale −$2,173,341 | 55,856 | Yes | Form 4 |
| Slamon Dennis | Mar 18, 2024 | Mar 20, 2024 | M | 10,000 | $79.70 | $797,000 | 40,809 | No | Form 4 |
| Slamon Dennis | Mar 18, 2024 | Mar 20, 2024 | F | 9,510 | $83.81 | $797,033 | 31,299 | No | Form 4 |
| Slamon Dennis | Mar 18, 2024 | Mar 20, 2024 | M · derivative | 10,000 | $79.70 | $797,000 | not reported | No | Form 4 |
| Burkhart ErinGVP, Chief Accounting Officer | Mar 18, 2024 | Mar 19, 2024 | F | 372 | $83.87 | $31,200 | 18,442 | No | Form 4 |
| Ajer Jeffrey RobertEVP, Chief Commercial Officer | Mar 15, 2024 | Mar 19, 2024 | F | 22,580 | $83.87 | $1,893,785 | 71,467 | No | Form 4 |
| Bienaime Jean Jacques | Mar 15, 2024 | Mar 19, 2024 | F | 85,209 | $83.87 | $7,146,479 | 474,994 | No | Form 4 |
| Hardy AlexanderChief Executive Officer | Mar 15, 2024 | Mar 19, 2024 | A | 32,780 | $0.00 | $0 | 148,151 | No | Form 4 |
| Hardy AlexanderChief Executive Officer | Mar 15, 2024 | Mar 19, 2024 | A · derivative | 44,050 | $83.87 | $3,694,474 | 44,050 | No | Form 4 |
| Fuchs Henry JPresident, Worldwide R&D | Mar 15, 2024 | Mar 19, 2024 | A | 18,240 | $0.00 | $0 | 230,357 | No | Form 4 |
| Fuchs Henry JPresident, Worldwide R&D | Mar 15, 2024 | Mar 19, 2024 | F | 33,485 | $83.87 | $2,808,387 | 196,872 | No | Form 4 |
| Fuchs Henry JPresident, Worldwide R&D | Mar 15, 2024 | Mar 19, 2024 | A · derivative | 40,860 | $83.87 | $3,426,928 | 40,860 | No | Form 4 |
| Mueller BrianEVP, Chief Financial Officer | Mar 15, 2024 | Mar 19, 2024 | A | 11,400 | $0.00 | $0 | 92,648 | No | Form 4 |
| Mueller BrianEVP, Chief Financial Officer | Mar 15, 2024 | Mar 19, 2024 | F | 20,789 | $83.87 | $1,743,573 | 71,859 | No | Form 4 |
| Mueller BrianEVP, Chief Financial Officer | Mar 15, 2024 | Mar 19, 2024 | A · derivative | 25,540 | $83.87 | $2,142,040 | 25,540 | No | Form 4 |
| Guyer Charles GregEVP, Chief Technical Officer | Mar 15, 2024 | Mar 19, 2024 | A | 10,550 | $0.00 | $0 | 98,751 | No | Form 4 |
| Guyer Charles GregEVP, Chief Technical Officer | Mar 15, 2024 | Mar 19, 2024 | F | 20,424 | $83.87 | $1,712,961 | 78,327 | No | Form 4 |
| Guyer Charles GregEVP, Chief Technical Officer | Mar 15, 2024 | Mar 19, 2024 | A · derivative | 23,630 | $83.87 | $1,981,848 | 23,630 | No | Form 4 |
| Davis George EricEVP, Chief Legal Officer | Mar 15, 2024 | Mar 19, 2024 | A | 10,260 | $0.00 | $0 | 102,157 | No | Form 4 |
| Davis George EricEVP, Chief Legal Officer | Mar 15, 2024 | Mar 19, 2024 | F | 21,699 | $83.87 | $1,819,895 | 80,458 | No | Form 4 |
| Davis George EricEVP, Chief Legal Officer | Mar 15, 2024 | Mar 19, 2024 | A · derivative | 22,990 | $83.87 | $1,928,171 | 22,990 | No | Form 4 |
| Burkhart ErinGVP, Chief Accounting Officer | Mar 15, 2024 | Mar 19, 2024 | A | 4,720 | $0.00 | $0 | 18,814 | No | Form 4 |
| Burkhart ErinGVP, Chief Accounting Officer | Mar 15, 2024 | Mar 19, 2024 | A · derivative | 7,050 | $83.87 | $591,284 | 7,050 | No | Form 4 |
| Bienaime Jean Jacques | Mar 6, 2024 | Mar 7, 2024 | S | 1,000 | $86.71 | Sale −$86,710 | 560,203 | No | Form 4 |
| Ajer Jeffrey RobertEVP, Chief Commercial Officer | Mar 5, 2024 | Mar 7, 2024 | S | 4,000 | $87.07 | Sale −$348,280 | 94,047 | Yes | Form 4 |
| Bienaime Jean Jacques | Mar 5, 2024 | Mar 7, 2024 | S | 1,000 | $85.51 | Sale −$85,510 | 561,203 | No | Form 4 |
| Fuchs Henry JPresident, Worldwide R&D | Mar 5, 2024 | Mar 7, 2024 | S | 35,341 | $85.18 | Sale −$3,010,346 | 212,117 | No | Form 4 |
| Bienaime Jean Jacques | Feb 27, 2024 | Feb 29, 2024 | A | 82,700 | $0.00 | $0 | 502,302 | No | Form 4 |
| Bienaime Jean Jacques | Feb 27, 2024 | Feb 29, 2024 | A | 35,975 | $0.00 | $0 | 538,277 | No | Form 4 |
| Bienaime Jean Jacques | Feb 27, 2024 | Feb 29, 2024 | A | 24,926 | $0.00 | $0 | 563,203 | No | Form 4 |
| Bienaime Jean Jacques | Feb 27, 2024 | Feb 29, 2024 | S | 1,000 | $90.35 | Sale −$90,350 | 562,203 | No | Form 4 |
| Fuchs Henry JPresident, Worldwide R&D | Feb 27, 2024 | Feb 29, 2024 | A | 30,640 | $0.00 | $0 | 224,894 | No | Form 4 |
| Fuchs Henry JPresident, Worldwide R&D | Feb 27, 2024 | Feb 29, 2024 | A | 13,326 | $0.00 | $0 | 238,220 | No | Form 4 |
| Fuchs Henry JPresident, Worldwide R&D | Feb 27, 2024 | Feb 29, 2024 | A | 9,238 | $0.00 | $0 | 247,458 | No | Form 4 |
| Ajer Jeffrey RobertEVP, Chief Commercial Officer | Feb 27, 2024 | Feb 29, 2024 | A | 21,440 | $0.00 | $0 | 82,244 | No | Form 4 |
| Ajer Jeffrey RobertEVP, Chief Commercial Officer | Feb 27, 2024 | Feb 29, 2024 | A | 9,338 | $0.00 | $0 | 91,582 | No | Form 4 |
| Ajer Jeffrey RobertEVP, Chief Commercial Officer | Feb 27, 2024 | Feb 29, 2024 | A | 6,465 | $0.00 | $0 | 98,047 | No | Form 4 |
| Guyer Charles GregEVP, Chief Technical Officer | Feb 27, 2024 | Feb 29, 2024 | A | 20,840 | $0.00 | $0 | 72,854 | No | Form 4 |
| Guyer Charles GregEVP, Chief Technical Officer | Feb 27, 2024 | Feb 29, 2024 | A | 9,063 | $0.00 | $0 | 81,917 | No | Form 4 |
| Guyer Charles GregEVP, Chief Technical Officer | Feb 27, 2024 | Feb 29, 2024 | A | 6,284 | $0.00 | $0 | 88,201 | No | Form 4 |
| Davis George EricEVP, Chief Legal Officer | Feb 27, 2024 | Feb 29, 2024 | A | 20,840 | $0.00 | $0 | 76,550 | No | Form 4 |
| Davis George EricEVP, Chief Legal Officer | Feb 27, 2024 | Feb 29, 2024 | A | 9,063 | $0.00 | $0 | 85,613 | No | Form 4 |
| Davis George EricEVP, Chief Legal Officer | Feb 27, 2024 | Feb 29, 2024 | A | 6,284 | $0.00 | $0 | 91,897 | No | Form 4 |
| Mueller BrianEVP, Chief Financial Officer | Feb 27, 2024 | Feb 29, 2024 | A | 20,220 | $0.00 | $0 | 66,343 | No | Form 4 |
| Mueller BrianEVP, Chief Financial Officer | Feb 27, 2024 | Feb 29, 2024 | A | 8,802 | $0.00 | $0 | 75,145 | No | Form 4 |
| Mueller BrianEVP, Chief Financial Officer | Feb 27, 2024 | Feb 29, 2024 | A | 6,103 | $0.00 | $0 | 81,248 | No | Form 4 |
| Bienaime Jean Jacques | Feb 9, 2024 | Feb 12, 2024 | M | 15,000 | $63.10 | $946,500 | 434,602 | Yes | Form 4 |
| Bienaime Jean Jacques | Feb 9, 2024 | Feb 12, 2024 | S | 15,000 | $88.28 | Sale −$1,324,200 | 419,602 | Yes | Form 4 |
| Bienaime Jean Jacques | Feb 9, 2024 | Feb 12, 2024 | M · derivative | 15,000 | $63.10 | $946,500 | 131,000 | Yes | Form 4 |
| Bienaime Jean Jacques | Feb 8, 2024 | Feb 12, 2024 | M | 15,000 | $63.10 | $946,500 | 434,602 | Yes | Form 4 |
| Bienaime Jean Jacques | Feb 8, 2024 | Feb 12, 2024 | S | 15,000 | $89.77 | Sale −$1,346,550 | 419,602 | Yes | Form 4 |
| Bienaime Jean Jacques | Feb 8, 2024 | Feb 12, 2024 | M · derivative | 15,000 | $63.10 | $946,500 | 146,000 | Yes | Form 4 |
| Bienaime Jean Jacques | Jan 18, 2024 | Feb 12, 2024 | L | 40 | $92.60 | $3,704 | 419,602 | Yes | Form 4 |
| Meier Richard A | Jan 8, 2024 | Jan 23, 2024 | G | 3,000 | $0.00 | $0 | 112,547 | No | Form 4 |
| Bienaime Jean Jacques | Jan 10, 2024 | Jan 11, 2024 | M | 10,000 | $63.10 | $631,000 | 435,162 | Yes | Form 4 |
| Bienaime Jean Jacques | Jan 10, 2024 | Jan 11, 2024 | S | 10,000 | $96.38 | Sale −$963,800 | 425,162 | Yes | Form 4 |
| Bienaime Jean Jacques | Jan 10, 2024 | Jan 11, 2024 | M · derivative | 10,000 | $63.10 | $631,000 | 161,000 | Yes | Form 4 |
| Bienaime Jean Jacques | Jan 9, 2024 | Jan 11, 2024 | M | 10,000 | $63.10 | $631,000 | 435,162 | Yes | Form 4 |
| Bienaime Jean Jacques | Jan 9, 2024 | Jan 11, 2024 | S | 10,000 | $98.19 | Sale −$981,900 | 425,162 | Yes | Form 4 |
| Bienaime Jean Jacques | Jan 9, 2024 | Jan 11, 2024 | M · derivative | 10,000 | $63.10 | $631,000 | 171,000 | Yes | Form 4 |
| Bienaime Jean Jacques | Jan 8, 2024 | Jan 11, 2024 | L | 50 | $99.05 | $4,953 | 425,162 | Yes | Form 4 |
| Countouriotis Athena | Dec 27, 2023 | Dec 28, 2023 | A | 2,180 | $0.00 | $0 | 2,180 | No | Form 4 |
| Enyedy Mark J | Dec 27, 2023 | Dec 28, 2023 | A | 2,180 | $0.00 | $0 | 2,180 | No | Form 4 |
| Bodem Barbara W. | Dec 27, 2023 | Dec 28, 2023 | A | 2,180 | $0.00 | $0 | 2,180 | No | Form 4 |
| Bienaime Jean Jacques | Dec 21, 2023 | Dec 22, 2023 | M | 10,000 | $63.10 | $631,000 | 435,112 | Yes | Form 4 |
| Bienaime Jean Jacques | Dec 21, 2023 | Dec 22, 2023 | S | 10,000 | $93.99 | Sale −$939,900 | 425,112 | Yes | Form 4 |
| Bienaime Jean Jacques | Dec 21, 2023 | Dec 22, 2023 | M · derivative | 10,000 | $63.10 | $631,000 | 181,000 | Yes | Form 4 |
| Davis George EricEVP, Chief Legal Officer | Dec 13, 2023 | Dec 14, 2023 | S | 13,764 | $95.30 | Sale −$1,311,709 | 55,710 | Yes | Form 4 |
| Bienaime Jean Jacques | Dec 1, 2023 | Dec 12, 2023 | A | 2,370 | $0.00 | $0 | 425,112 | No | Form 4 |
| Bienaime Jean Jacques | Oct 4, 2023 | Dec 12, 2023 | L | 10 | $85.57 | $856 | 422,742 | No | Form 4 |
| Fuchs Henry JPresident, Worldwide R&D | Dec 1, 2023 | Dec 5, 2023 | A | 17,750 | $0.00 | $0 | 194,254 | No | Form 4 |
| Guyer Charles GregEVP, Chief Technical Officer | Dec 1, 2023 | Dec 5, 2023 | A | 11,840 | $0.00 | $0 | 52,014 | No | Form 4 |
| Hardy AlexanderChief Executive Officer | Dec 1, 2023 | Dec 5, 2023 | A | 68,039 | $0.00 | $0 | 68,039 | No | Form 4 |
| Hardy AlexanderChief Executive Officer | Dec 1, 2023 | Dec 5, 2023 | A | 47,332 | $0.00 | $0 | 115,371 | No | Form 4 |
| Hardy AlexanderChief Executive Officer | Dec 1, 2023 | Dec 5, 2023 | A · derivative | 150,529 | $92.42 | $13,911,890 | 150,529 | No | Form 4 |
| Guyer Charles GregEVP, Chief Technical Officer | Oct 31, 2023 | Dec 5, 2023 | A | 133 | $69.23 | $9,208 | 40,174 | No | Form 4 |
| Fuchs Henry JPresident, Worldwide R&D | Apr 28, 2023 | Dec 5, 2023 | A | 317 | $66.88 | $21,201 | 176,504 | No | Form 4 |