CRNXCrinetics Pharmaceuticals, Inc.
- Market cap
- not reported
- Latest close
- not reported
- Sector
- Healthcare
- as of 2026-10-24
- Industry
- Biotechnology
- as of 2026-10-24
Values marked — are missing or out of date.
Cluster
No cluster in the last 90 days under the default rule (14d · ≥2 insiders · all roles).
Form 4 historysince 2023-10-19
| Insider | Traded | Filed | Type | Shares | Price | Value | Owned after | 10b5-1 plan | Filing |
|---|---|---|---|---|---|---|---|---|---|
| Struthers Richard ScottPresident & CEO | Sep 1 | Sep 1 | D | 248,043 | $85.00 | $21,083,655 | 176,663 | No | Form 4 |
| Struthers Richard ScottPresident & CEO | Sep 1 | Sep 1 | D | 1,000 | $85.00 | $85,000 | not reported | No | Form 4 |
| Struthers Richard ScottPresident & CEO | Sep 1 | Sep 1 | D | 136,805 | $85.00 | $11,628,425 | not reported | No | Form 4 |
| Struthers Richard ScottPresident & CEO | Sep 1 | Sep 1 | D | 106,000 | $85.00 | $9,010,000 | not reported | No | Form 4 |
| Struthers Richard ScottPresident & CEO | Sep 1 | Sep 1 | D | 110,000 | $85.00 | $9,350,000 | not reported | No | Form 4 |
| Struthers Richard ScottPresident & CEO | Sep 1 | Sep 1 | D | 100,000 | $85.00 | $8,500,000 | not reported | No | Form 4 |
| Struthers Richard ScottPresident & CEO | Sep 1 | Sep 1 | D | 111,100 | $85.00 | $9,443,500 | not reported | No | Form 4 |
| Struthers Richard ScottPresident & CEO | Sep 1 | Sep 1 | D | 111,100 | $85.00 | $9,443,500 | not reported | No | Form 4 |
| Struthers Richard ScottPresident & CEO | Sep 1 | Sep 1 | D | 111,100 | $85.00 | $9,443,500 | not reported | No | Form 4 |
| Struthers Richard ScottPresident & CEO | Sep 1 | Sep 1 | D | 111,100 | $85.00 | $9,443,500 | not reported | No | Form 4 |
| Struthers Richard ScottPresident & CEO | Sep 1 | Sep 1 | D | 80,000 | $85.00 | $6,800,000 | not reported | No | Form 4 |
| Struthers Richard ScottPresident & CEO | Sep 1 | Sep 1 | D | 176,663 | $85.00 | $15,016,355 | not reported | No | Form 4 |
| Struthers Richard ScottPresident & CEO | Sep 1 | Sep 1 | D · derivative | 172,281 | $59.81 | $10,304,127 | not reported | No | Form 4 |
| Struthers Richard ScottPresident & CEO | Sep 1 | Sep 1 | D · derivative | 195,578 | $62.39 | $12,202,111 | not reported | No | Form 4 |
| Struthers Richard ScottPresident & CEO | Sep 1 | Sep 1 | D · derivative | 259,058 | $69.71 | $18,058,933 | not reported | No | Form 4 |
| Struthers Richard ScottPresident & CEO | Sep 1 | Sep 1 | D · derivative | 244,205 | $64.98 | $15,868,441 | not reported | No | Form 4 |
| Struthers Richard ScottPresident & CEO | Sep 1 | Sep 1 | D · derivative | 287,700 | $65.36 | $18,804,072 | not reported | No | Form 4 |
| Struthers Richard ScottPresident & CEO | Sep 1 | Sep 1 | D · derivative | 240,000 | $41.49 | $9,957,600 | not reported | No | Form 4 |
| Struthers Richard ScottPresident & CEO | Sep 1 | Sep 1 | D · derivative | 313,000 | $48.14 | $15,067,820 | not reported | No | Form 4 |
| Struthers Richard ScottPresident & CEO | Sep 1 | Sep 1 | D · derivative | 228,000 | $41.21 | $9,395,880 | not reported | No | Form 4 |
| Schilke TobinChief Financial & Infra. Ofcr. | Sep 1 | Sep 1 | D | 7,956 | $85.00 | $676,260 | 71,471 | No | Form 4 |
| Schilke TobinChief Financial & Infra. Ofcr. | Sep 1 | Sep 1 | D | 71,471 | $85.00 | $6,075,035 | not reported | No | Form 4 |
| Schilke TobinChief Financial & Infra. Ofcr. | Sep 1 | Sep 1 | D · derivative | 80,000 | $51.25 | $4,100,000 | not reported | No | Form 4 |
| Schilke TobinChief Financial & Infra. Ofcr. | Sep 1 | Sep 1 | D · derivative | 50,000 | $41.21 | $2,060,500 | not reported | No | Form 4 |
| Betz Stephen F.Chief Scientific Officer | Sep 1 | Sep 1 | D | 58,286 | $85.00 | $4,954,310 | 79,650 | No | Form 4 |
| Betz Stephen F.Chief Scientific Officer | Sep 1 | Sep 1 | D | 79,650 | $85.00 | $6,770,250 | not reported | No | Form 4 |
| Betz Stephen F.Chief Scientific Officer | Sep 1 | Sep 1 | D · derivative | 90,514 | $83.09 | $7,520,808 | not reported | No | Form 4 |
| Betz Stephen F.Chief Scientific Officer | Sep 1 | Sep 1 | D · derivative | 74,540 | $75.72 | $5,644,169 | not reported | No | Form 4 |
| Betz Stephen F.Chief Scientific Officer | Sep 1 | Sep 1 | D · derivative | 56,250 | $59.81 | $3,364,313 | not reported | No | Form 4 |
| Betz Stephen F.Chief Scientific Officer | Sep 1 | Sep 1 | D · derivative | 60,000 | $62.39 | $3,743,400 | not reported | No | Form 4 |
| Betz Stephen F.Chief Scientific Officer | Sep 1 | Sep 1 | D · derivative | 85,000 | $69.71 | $5,925,350 | not reported | No | Form 4 |
| Betz Stephen F.Chief Scientific Officer | Sep 1 | Sep 1 | D · derivative | 15,000 | $61.81 | $927,150 | not reported | No | Form 4 |
| Betz Stephen F.Chief Scientific Officer | Sep 1 | Sep 1 | D · derivative | 77,000 | $64.98 | $5,003,460 | not reported | No | Form 4 |
| Betz Stephen F.Chief Scientific Officer | Sep 1 | Sep 1 | D · derivative | 110,000 | $65.36 | $7,189,600 | not reported | No | Form 4 |
| Betz Stephen F.Chief Scientific Officer | Sep 1 | Sep 1 | D · derivative | 87,000 | $41.49 | $3,609,630 | not reported | No | Form 4 |
| Betz Stephen F.Chief Scientific Officer | Sep 1 | Sep 1 | D · derivative | 65,000 | $48.14 | $3,129,100 | not reported | No | Form 4 |
| Betz Stephen F.Chief Scientific Officer | Sep 1 | Sep 1 | D · derivative | 47,000 | $41.21 | $1,936,870 | not reported | No | Form 4 |
| Kalofonos IsabelChief Commercial Officer | Sep 1 | Sep 1 | D | 1,669 | $85.00 | $141,865 | 34,000 | No | Form 4 |
| Kalofonos IsabelChief Commercial Officer | Sep 1 | Sep 1 | D | 34,000 | $85.00 | $2,890,000 | not reported | No | Form 4 |
| Kalofonos IsabelChief Commercial Officer | Sep 1 | Sep 1 | D · derivative | 97,500 | $44.41 | $4,329,975 | not reported | No | Form 4 |
| Kalofonos IsabelChief Commercial Officer | Sep 1 | Sep 1 | D · derivative | 55,000 | $41.21 | $2,266,550 | not reported | No | Form 4 |
| Bedrosian Camille L | Sep 1 | Sep 1 | D | 16,300 | $85.00 | $1,385,500 | 5,925 | No | Form 4 |
| Bedrosian Camille L | Sep 1 | Sep 1 | D | 5,925 | $85.00 | $503,625 | not reported | No | Form 4 |
| Bedrosian Camille L | Sep 1 | Sep 1 | D · derivative | 25,000 | $68.92 | $1,723,000 | not reported | No | Form 4 |
| Bedrosian Camille L | Sep 1 | Sep 1 | D · derivative | 17,500 | $64.77 | $1,133,475 | not reported | No | Form 4 |
| Bedrosian Camille L | Sep 1 | Sep 1 | D · derivative | 17,500 | $66.71 | $1,167,425 | not reported | No | Form 4 |
| Bedrosian Camille L | Sep 1 | Sep 1 | D · derivative | 17,500 | $64.68 | $1,131,900 | not reported | No | Form 4 |
| Bedrosian Camille L | Sep 1 | Sep 1 | D · derivative | 12,500 | $40.29 | $503,625 | not reported | No | Form 4 |
| Bedrosian Camille L | Sep 1 | Sep 1 | D · derivative | 10,350 | $52.67 | $545,135 | not reported | No | Form 4 |
| Bedrosian Camille L | Sep 1 | Sep 1 | D · derivative | 9,730 | $49.13 | $478,035 | not reported | No | Form 4 |
| Deardorf Caren | Sep 1 | Sep 1 | D | 16,300 | $85.00 | $1,385,500 | 5,925 | No | Form 4 |
| Deardorf Caren | Sep 1 | Sep 1 | D | 5,925 | $85.00 | $503,625 | not reported | No | Form 4 |
| Deardorf Caren | Sep 1 | Sep 1 | D · derivative | 35,000 | $65.70 | $2,299,500 | not reported | No | Form 4 |
| Deardorf Caren | Sep 1 | Sep 1 | D · derivative | 4,375 | $66.71 | $291,856 | not reported | No | Form 4 |
| Deardorf Caren | Sep 1 | Sep 1 | D · derivative | 17,500 | $64.68 | $1,131,900 | not reported | No | Form 4 |
| Deardorf Caren | Sep 1 | Sep 1 | D · derivative | 12,500 | $40.29 | $503,625 | not reported | No | Form 4 |
| Deardorf Caren | Sep 1 | Sep 1 | D · derivative | 10,350 | $52.67 | $545,135 | not reported | No | Form 4 |
| Deardorf Caren | Sep 1 | Sep 1 | D · derivative | 9,730 | $49.13 | $478,035 | not reported | No | Form 4 |
| Fust Matthew K | Sep 1 | Sep 1 | D | 22,836 | $85.00 | $1,941,060 | 5,925 | No | Form 4 |
| Fust Matthew K | Sep 1 | Sep 1 | D | 5,925 | $85.00 | $503,625 | not reported | No | Form 4 |
| Fust Matthew K | Sep 1 | Sep 1 | D · derivative | 2,092 | $83.09 | $173,824 | not reported | No | Form 4 |
| Fust Matthew K | Sep 1 | Sep 1 | D · derivative | 17,500 | $64.68 | $1,131,900 | not reported | No | Form 4 |
| Fust Matthew K | Sep 1 | Sep 1 | D · derivative | 12,500 | $40.29 | $503,625 | not reported | No | Form 4 |
| Fust Matthew K | Sep 1 | Sep 1 | D · derivative | 10,350 | $52.67 | $545,135 | not reported | No | Form 4 |
| Fust Matthew K | Sep 1 | Sep 1 | D · derivative | 9,730 | $49.13 | $478,035 | not reported | No | Form 4 |
| Nichols Weston | Sep 1 | Sep 1 | D | 16,300 | $85.00 | $1,385,500 | 5,925 | No | Form 4 |
| Nichols Weston | Sep 1 | Sep 1 | D | 5,925 | $85.00 | $503,625 | not reported | No | Form 4 |
| Nichols Weston | Sep 1 | Sep 1 | D · derivative | 12,500 | $61.76 | $772,000 | not reported | No | Form 4 |
| Nichols Weston | Sep 1 | Sep 1 | D · derivative | 12,500 | $61.77 | $772,125 | not reported | No | Form 4 |
| Nichols Weston | Sep 1 | Sep 1 | D · derivative | 17,500 | $64.77 | $1,133,475 | not reported | No | Form 4 |
| Nichols Weston | Sep 1 | Sep 1 | D · derivative | 17,500 | $66.71 | $1,167,425 | not reported | No | Form 4 |
| Nichols Weston | Sep 1 | Sep 1 | D · derivative | 17,500 | $64.68 | $1,131,900 | not reported | No | Form 4 |
| Nichols Weston | Sep 1 | Sep 1 | D · derivative | 12,500 | $40.29 | $503,625 | not reported | No | Form 4 |
| Nichols Weston | Sep 1 | Sep 1 | D · derivative | 10,350 | $52.67 | $545,135 | not reported | No | Form 4 |
| Nichols Weston | Sep 1 | Sep 1 | D · derivative | 9,730 | $49.13 | $478,035 | not reported | No | Form 4 |
| Okey Stephanie | Sep 1 | Sep 1 | D | 6,400 | $85.00 | $544,000 | 5,925 | No | Form 4 |
| Okey Stephanie | Sep 1 | Sep 1 | D | 5,925 | $85.00 | $503,625 | not reported | No | Form 4 |
| Okey Stephanie | Sep 1 | Sep 1 | D · derivative | 25,000 | $60.85 | $1,521,250 | not reported | No | Form 4 |
| Okey Stephanie | Sep 1 | Sep 1 | D · derivative | 12,500 | $61.77 | $772,125 | not reported | No | Form 4 |
| Okey Stephanie | Sep 1 | Sep 1 | D · derivative | 17,500 | $64.77 | $1,133,475 | not reported | No | Form 4 |
| Okey Stephanie | Sep 1 | Sep 1 | D · derivative | 17,500 | $64.68 | $1,131,900 | not reported | No | Form 4 |
| Okey Stephanie | Sep 1 | Sep 1 | D · derivative | 12,500 | $40.29 | $503,625 | not reported | No | Form 4 |
| Okey Stephanie | Sep 1 | Sep 1 | D · derivative | 10,350 | $52.67 | $545,135 | not reported | No | Form 4 |
| Okey Stephanie | Sep 1 | Sep 1 | D · derivative | 9,730 | $49.13 | $478,035 | not reported | No | Form 4 |
| Vivaldi Coelho Rogerio | Sep 1 | Sep 1 | D | 13,300 | $85.00 | $1,130,500 | 5,925 | No | Form 4 |
| Vivaldi Coelho Rogerio | Sep 1 | Sep 1 | D | 5,925 | $85.00 | $503,625 | not reported | No | Form 4 |
| Vivaldi Coelho Rogerio | Sep 1 | Sep 1 | D · derivative | 35,000 | $56.69 | $1,984,150 | not reported | No | Form 4 |
| Vivaldi Coelho Rogerio | Sep 1 | Sep 1 | D · derivative | 8,750 | $66.71 | $583,713 | not reported | No | Form 4 |
| Vivaldi Coelho Rogerio | Sep 1 | Sep 1 | D · derivative | 17,500 | $64.68 | $1,131,900 | not reported | No | Form 4 |
| Vivaldi Coelho Rogerio | Sep 1 | Sep 1 | D · derivative | 12,500 | $40.29 | $503,625 | not reported | No | Form 4 |
| Vivaldi Coelho Rogerio | Sep 1 | Sep 1 | D · derivative | 10,350 | $52.67 | $545,135 | not reported | No | Form 4 |
| Vivaldi Coelho Rogerio | Sep 1 | Sep 1 | D · derivative | 9,730 | $49.13 | $478,035 | not reported | No | Form 4 |
| Wierenga Wendell | Sep 1 | Sep 1 | D | 116,146 | $85.00 | $9,872,410 | 5,925 | No | Form 4 |
| Wierenga Wendell | Sep 1 | Sep 1 | D | 5,925 | $85.00 | $503,625 | not reported | No | Form 4 |
| Wierenga Wendell | Sep 1 | Sep 1 | D · derivative | 12,500 | $61.76 | $772,000 | not reported | No | Form 4 |
| Wierenga Wendell | Sep 1 | Sep 1 | D · derivative | 12,500 | $61.77 | $772,125 | not reported | No | Form 4 |
| Wierenga Wendell | Sep 1 | Sep 1 | D · derivative | 17,500 | $64.77 | $1,133,475 | not reported | No | Form 4 |
| Wierenga Wendell | Sep 1 | Sep 1 | D · derivative | 17,500 | $66.71 | $1,167,425 | not reported | No | Form 4 |
| Wierenga Wendell | Sep 1 | Sep 1 | D · derivative | 17,500 | $64.68 | $1,131,900 | not reported | No | Form 4 |
| Wierenga Wendell | Sep 1 | Sep 1 | D · derivative | 12,500 | $40.29 | $503,625 | not reported | No | Form 4 |
| Wierenga Wendell | Sep 1 | Sep 1 | D · derivative | 10,350 | $52.67 | $545,135 | not reported | No | Form 4 |
| Wierenga Wendell | Sep 1 | Sep 1 | D · derivative | 9,730 | $49.13 | $478,035 | not reported | No | Form 4 |
| Schilke TobinChief Financial & Infra. Ofcr. | Aug 20 | Aug 24 | A | 471 | $0.00 | $0 | 79,427 | No | Form 4 |
| Struthers Richard ScottPresident & CEO | Aug 7 | Aug 11 | M | 3,969 | $25.19 | $99,979 | 408,747 | No | Form 4 |
| Struthers Richard ScottPresident & CEO | Aug 7 | Aug 11 | M | 4,422 | $22.61 | $99,981 | 413,169 | No | Form 4 |
| Struthers Richard ScottPresident & CEO | Aug 7 | Aug 11 | M | 6,542 | $15.29 | $100,027 | 419,711 | No | Form 4 |
| Struthers Richard ScottPresident & CEO | Aug 7 | Aug 11 | M | 4,995 | $20.02 | $100,000 | 424,706 | No | Form 4 |
| Struthers Richard ScottPresident & CEO | Aug 7 | Aug 11 | M · derivative | 3,969 | $25.19 | $99,979 | 172,281 | No | Form 4 |
| Struthers Richard ScottPresident & CEO | Aug 7 | Aug 11 | M · derivative | 4,422 | $22.61 | $99,981 | 195,578 | No | Form 4 |
| Struthers Richard ScottPresident & CEO | Aug 7 | Aug 11 | M · derivative | 6,542 | $15.29 | $100,027 | 259,058 | No | Form 4 |
| Struthers Richard ScottPresident & CEO | Aug 7 | Aug 11 | M · derivative | 4,995 | $20.02 | $100,000 | 244,205 | No | Form 4 |
| Vivaldi Coelho Rogerio | Jul 2 | Jul 7 | S | 3,000 | $40.00 | Sale −$120,000 | 19,225 | Yes | Form 4 |
| Okey Stephanie | Jun 18 | Jun 22 | A | 5,925 | $0.00 | $0 | 12,325 | No | Form 4 |
| Okey Stephanie | Jun 18 | Jun 22 | A · derivative | 9,730 | $35.87 | $349,015 | 9,730 | No | Form 4 |
| Wierenga Wendell | Jun 18 | Jun 22 | A | 5,925 | $0.00 | $0 | 122,071 | No | Form 4 |
| Wierenga Wendell | Jun 18 | Jun 22 | A · derivative | 9,730 | $35.87 | $349,015 | 9,730 | No | Form 4 |
| Bedrosian Camille L | Jun 18 | Jun 22 | A | 5,925 | $0.00 | $0 | 22,225 | No | Form 4 |
| Bedrosian Camille L | Jun 18 | Jun 22 | A · derivative | 9,730 | $35.87 | $349,015 | 9,730 | No | Form 4 |
| Vivaldi Coelho Rogerio | Jun 18 | Jun 22 | A | 5,925 | $0.00 | $0 | 22,225 | No | Form 4 |
| Vivaldi Coelho Rogerio | Jun 18 | Jun 22 | A · derivative | 9,730 | $35.87 | $349,015 | 9,730 | No | Form 4 |
| Nichols Weston | Jun 18 | Jun 22 | A | 5,925 | $0.00 | $0 | 22,225 | No | Form 4 |
| Nichols Weston | Jun 18 | Jun 22 | A · derivative | 9,730 | $35.87 | $349,015 | 9,730 | No | Form 4 |
| Fust Matthew K | Jun 18 | Jun 22 | A | 5,925 | $0.00 | $0 | 28,761 | No | Form 4 |
| Fust Matthew K | Jun 18 | Jun 22 | A · derivative | 9,730 | $35.87 | $349,015 | 9,730 | No | Form 4 |
| Deardorf Caren | Jun 18 | Jun 22 | A | 5,925 | $0.00 | $0 | 22,225 | No | Form 4 |
| Deardorf Caren | Jun 18 | Jun 22 | A · derivative | 9,730 | $35.87 | $349,015 | 9,730 | No | Form 4 |
| Okey Stephanie | Jun 17 | Jun 18 | S | 6,292 | $35.62 | Sale −$224,121 | 7,008 | Yes | Form 4 |
| Okey Stephanie | Jun 17 | Jun 18 | S | 608 | $36.22 | Sale −$22,022 | 6,400 | Yes | Form 4 |
| Struthers Richard ScottPresident & CEO | May 29 | Jun 2 | G | 222,200 | $0.00 | $0 | 439,005 | No | Form 4 |
| Struthers Richard ScottPresident & CEO | May 29 | Jun 2 | G | 222,200 | $0.00 | $0 | 216,805 | No | Form 4 |
| Struthers Richard ScottPresident & CEO | May 29 | Jun 2 | G | 80,000 | $0.00 | $0 | 136,805 | No | Form 4 |
| Struthers Richard ScottPresident & CEO | May 29 | Jun 2 | G | 222,200 | $0.00 | $0 | 626,978 | No | Form 4 |
| Struthers Richard ScottPresident & CEO | May 29 | Jun 2 | G | 222,200 | $0.00 | $0 | 223,200 | No | Form 4 |
| Struthers Richard ScottPresident & CEO | May 29 | Jun 2 | G | 80,000 | $0.00 | $0 | 80,000 | No | Form 4 |
| Struthers Richard ScottPresident & CEO | May 29 | Jun 2 | G | 111,100 | $0.00 | $0 | 515,878 | No | Form 4 |
| Struthers Richard ScottPresident & CEO | May 29 | Jun 2 | G | 111,100 | $0.00 | $0 | 404,778 | No | Form 4 |
| Struthers Richard ScottPresident & CEO | May 29 | Jun 2 | G | 111,100 | $0.00 | $0 | 111,100 | No | Form 4 |
| Struthers Richard ScottPresident & CEO | May 29 | Jun 2 | G | 111,100 | $0.00 | $0 | 111,100 | No | Form 4 |
| Struthers Richard ScottPresident & CEO | May 29 | Jun 2 | G | 111,100 | $0.00 | $0 | 112,100 | No | Form 4 |
| Struthers Richard ScottPresident & CEO | May 29 | Jun 2 | G | 111,100 | $0.00 | $0 | 1,000 | No | Form 4 |
| Struthers Richard ScottPresident & CEO | May 29 | Jun 2 | G | 111,100 | $0.00 | $0 | 111,100 | No | Form 4 |
| Struthers Richard ScottPresident & CEO | May 29 | Jun 2 | G | 111,100 | $0.00 | $0 | 111,100 | No | Form 4 |
| Knight Jeff E.Chief Dev. & Operating Officer | Apr 8 | Apr 10 | M | 49,474 | $23.98 | $1,186,387 | 161,492 | Yes | Form 4 |
| Knight Jeff E.Chief Dev. & Operating Officer | Apr 8 | Apr 10 | M | 9,624 | $20.02 | $192,672 | 171,116 | Yes | Form 4 |
| Knight Jeff E.Chief Dev. & Operating Officer | Apr 8 | Apr 10 | M | 19,336 | $19.64 | $379,759 | 190,452 | Yes | Form 4 |
| Knight Jeff E.Chief Dev. & Operating Officer | Apr 8 | Apr 10 | S | 85,163 | $40.10 | Sale −$3,415,036 | 105,289 | Yes | Form 4 |
| Knight Jeff E.Chief Dev. & Operating Officer | Apr 8 | Apr 10 | M · derivative | 49,474 | $23.98 | $1,186,387 | 63,027 | Yes | Form 4 |
| Knight Jeff E.Chief Dev. & Operating Officer | Apr 8 | Apr 10 | M · derivative | 9,624 | $20.02 | $192,672 | 10,589 | Yes | Form 4 |
| Knight Jeff E.Chief Dev. & Operating Officer | Apr 8 | Apr 10 | M · derivative | 19,336 | $19.64 | $379,759 | 65,977 | Yes | Form 4 |
| Struthers Richard ScottPresident & CEO | Mar 16 | Mar 18 | S | 13,196 | $37.11 | Sale −$489,704 | 413,563 | Yes | Form 4 |
| Struthers Richard ScottPresident & CEO | Mar 16 | Mar 18 | S | 8,785 | $37.77 | Sale −$331,809 | 404,778 | Yes | Form 4 |
| Betz Stephen F.Chief Scientific Officer | Mar 16 | Mar 18 | S | 6,371 | $37.11 | Sale −$236,428 | 141,342 | Yes | Form 4 |
| Betz Stephen F.Chief Scientific Officer | Mar 16 | Mar 18 | S | 4,241 | $37.77 | Sale −$160,183 | 137,101 | Yes | Form 4 |
| Knight Jeff E.Chief Operating Officer | Mar 16 | Mar 18 | S | 5,950 | $37.11 | Sale −$220,805 | 115,979 | Yes | Form 4 |
| Knight Jeff E.Chief Operating Officer | Mar 16 | Mar 18 | S | 3,961 | $37.77 | Sale −$149,607 | 112,018 | Yes | Form 4 |
| Vivaldi Coelho Rogerio | Mar 12 | Mar 13 | S | 4,477 | $36.08 | Sale −$161,530 | 16,823 | Yes | Form 4 |
| Vivaldi Coelho Rogerio | Mar 12 | Mar 13 | S | 523 | $36.77 | Sale −$19,231 | 16,300 | Yes | Form 4 |
| Schilke TobinChief Financial Officer | Mar 3 | Mar 4 | S | 6,713 | $39.67 | Sale −$266,305 | 78,121 | Yes | Form 4 |
| Okey Stephanie | Mar 3 | Mar 4 | S | 3,000 | $39.67 | Sale −$119,010 | 13,300 | Yes | Form 4 |
| Kalofonos IsabelChief Commercial Officer | Feb 23 | Feb 25 | A | 34,000 | $0.00 | $0 | 34,834 | No | Form 4 |
| Kalofonos IsabelChief Commercial Officer | Feb 23 | Feb 25 | A · derivative | 55,000 | $43.79 | $2,408,450 | 55,000 | No | Form 4 |
| Betz Stephen F.Chief Scientific Officer | Feb 23 | Feb 25 | A | 30,000 | $0.00 | $0 | 147,713 | No | Form 4 |
| Betz Stephen F.Chief Scientific Officer | Feb 23 | Feb 25 | A · derivative | 47,000 | $43.79 | $2,058,130 | 47,000 | No | Form 4 |
| Knight Jeff E.Chief Operating Officer | Feb 23 | Feb 25 | A | 34,000 | $0.00 | $0 | 121,929 | No | Form 4 |
| Knight Jeff E.Chief Operating Officer | Feb 23 | Feb 25 | A · derivative | 55,000 | $43.79 | $2,408,450 | 55,000 | No | Form 4 |
| Schilke TobinChief Financial Officer | Feb 23 | Feb 25 | A | 32,000 | $0.00 | $0 | 84,834 | No | Form 4 |
| Schilke TobinChief Financial Officer | Feb 23 | Feb 25 | A · derivative | 50,000 | $43.79 | $2,189,500 | 50,000 | No | Form 4 |
| Struthers Richard ScottPresident & CEO | Feb 23 | Feb 25 | A | 62,000 | $0.00 | $0 | 426,759 | No | Form 4 |
| Struthers Richard ScottPresident & CEO | Feb 23 | Feb 25 | A · derivative | 228,000 | $43.79 | $9,984,120 | 228,000 | No | Form 4 |
| Kalofonos IsabelChief Commercial Officer | Jan 5 | Jan 7 | M | 2,500 | $40.59 | $101,475 | 3,334 | Yes | Form 4 |
| Kalofonos IsabelChief Commercial Officer | Jan 5 | Jan 7 | S | 2,500 | $55.00 | Sale −$137,500 | 834 | Yes | Form 4 |
| Kalofonos IsabelChief Commercial Officer | Jan 5 | Jan 7 | M · derivative | 2,500 | $40.59 | $101,475 | 97,500 | Yes | Form 4 |
| Betz Stephen F.Chief Scientific Officer | Dec 26, 2025 | Dec 29, 2025 | M | 18,000 | $1.91 | $34,380 | 117,713 | No | Form 4 |
| Betz Stephen F.Chief Scientific Officer | Dec 26, 2025 | Dec 29, 2025 | M · derivative | 18,000 | $1.91 | $34,380 | 90,514 | No | Form 4 |
| Struthers Richard ScottPresident & CEO | Dec 18, 2025 | Dec 18, 2025 | M | 16,342 | $9.28 | $151,654 | 336,359 | No | Form 4 |
| Struthers Richard ScottPresident & CEO | Dec 18, 2025 | Dec 18, 2025 | M | 28,400 | $15.29 | $434,236 | 364,759 | No | Form 4 |
| Struthers Richard ScottPresident & CEO | Dec 18, 2025 | Dec 18, 2025 | M · derivative | 16,342 | $9.28 | $151,654 | not reported | No | Form 4 |
| Struthers Richard ScottPresident & CEO | Dec 18, 2025 | Dec 18, 2025 | M · derivative | 28,400 | $15.29 | $434,236 | 259,058 | No | Form 4 |
| Pizzuti DanaChief Med and Dev Officer | Dec 1, 2025 | Dec 3, 2025 | M | 5,000 | $16.89 | $84,450 | 71,837 | Yes | Form 4 |
| Pizzuti DanaChief Med and Dev Officer | Dec 1, 2025 | Dec 3, 2025 | S | 5,000 | $45.02 | Sale −$225,100 | 66,837 | Yes | Form 4 |
| Pizzuti DanaChief Med and Dev Officer | Dec 1, 2025 | Dec 3, 2025 | M · derivative | 5,000 | $16.89 | $84,450 | 69,042 | Yes | Form 4 |
| Pizzuti DanaChief Med and Dev Officer | Nov 3, 2025 | Nov 5, 2025 | M | 5,000 | $16.89 | $84,450 | 71,270 | Yes | Form 4 |
| Pizzuti DanaChief Med and Dev Officer | Nov 3, 2025 | Nov 5, 2025 | S | 4,900 | $42.65 | Sale −$208,985 | 66,370 | Yes | Form 4 |
| Pizzuti DanaChief Med and Dev Officer | Nov 3, 2025 | Nov 5, 2025 | S | 100 | $43.27 | Sale −$4,327 | 66,270 | Yes | Form 4 |
| Pizzuti DanaChief Med and Dev Officer | Nov 3, 2025 | Nov 5, 2025 | M · derivative | 5,000 | $16.89 | $84,450 | 74,042 | Yes | Form 4 |
| Pizzuti DanaChief Med and Dev Officer | Oct 1, 2025 | Oct 3, 2025 | M | 5,000 | $16.89 | $84,450 | 71,270 | Yes | Form 4 |
| Pizzuti DanaChief Med and Dev Officer | Oct 1, 2025 | Oct 3, 2025 | S | 5,000 | $41.81 | Sale −$209,050 | 66,270 | Yes | Form 4 |
| Pizzuti DanaChief Med and Dev Officer | Oct 1, 2025 | Oct 3, 2025 | M · derivative | 5,000 | $16.89 | $84,450 | 79,042 | Yes | Form 4 |
| Fust Matthew K | Sep 26, 2025 | Sep 30, 2025 | M | 10,000 | $1.91 | $19,100 | 38,836 | Yes | Form 4 |
| Fust Matthew K | Sep 26, 2025 | Sep 30, 2025 | S | 16,000 | $44.75 | Sale −$716,000 | 22,836 | Yes | Form 4 |
| Fust Matthew K | Sep 26, 2025 | Sep 30, 2025 | M · derivative | 10,000 | $1.91 | $19,100 | 2,092 | Yes | Form 4 |
| Struthers Richard ScottPresident & CEO | Sep 26, 2025 | Sep 30, 2025 | S | 4,000 | $45.00 | Sale −$180,000 | 106,000 | Yes | Form 4 |
| Pizzuti DanaChief Med and Dev Officer | Sep 2, 2025 | Sep 4, 2025 | M | 5,000 | $16.89 | $84,450 | 101,270 | Yes | Form 4 |
| Pizzuti DanaChief Med and Dev Officer | Sep 2, 2025 | Sep 4, 2025 | S | 5,000 | $32.10 | Sale −$160,500 | 96,270 | Yes | Form 4 |
| Pizzuti DanaChief Med and Dev Officer | Sep 2, 2025 | Sep 4, 2025 | M · derivative | 5,000 | $16.89 | $84,450 | 84,042 | Yes | Form 4 |
| Pizzuti DanaChief Med and Dev Officer | Aug 22, 2025 | Aug 26, 2025 | M | 30,000 | $16.89 | $506,700 | 96,270 | Yes | Form 4 |
| Pizzuti DanaChief Med and Dev Officer | Aug 22, 2025 | Aug 26, 2025 | S | 30,000 | $30.43 | Sale −$912,900 | 66,270 | Yes | Form 4 |
| Pizzuti DanaChief Med and Dev Officer | Aug 22, 2025 | Aug 26, 2025 | M · derivative | 30,000 | $16.89 | $506,700 | 89,042 | Yes | Form 4 |
| Pizzuti DanaChief Med and Dev Officer | Aug 20, 2025 | Aug 21, 2025 | S | 6,492 | $29.18 | Sale −$189,437 | 66,270 | Yes | Form 4 |
| Betz Stephen F.Chief Scientific Officer | Jun 12, 2025 | Jun 16, 2025 | M | 71,525 | $1.91 | $136,613 | 180,551 | Yes | Form 4 |
| Betz Stephen F.Chief Scientific Officer | Jun 12, 2025 | Jun 16, 2025 | M | 16,645 | $9.28 | $154,466 | 197,196 | Yes | Form 4 |
| Betz Stephen F.Chief Scientific Officer | Jun 12, 2025 | Jun 16, 2025 | S | 97,483 | $32.23 | Sale −$3,141,877 | 99,713 | Yes | Form 4 |
| Betz Stephen F.Chief Scientific Officer | Jun 12, 2025 | Jun 16, 2025 | M · derivative | 71,525 | $1.91 | $136,613 | 108,514 | Yes | Form 4 |
| Betz Stephen F.Chief Scientific Officer | Jun 12, 2025 | Jun 16, 2025 | M · derivative | 16,645 | $9.28 | $154,466 | 58,198 | Yes | Form 4 |
| Wierenga Wendall | Jun 11, 2025 | Jun 13, 2025 | A | 6,900 | $0.00 | $0 | 116,146 | No | Form 4 |
| Wierenga Wendall | Jun 11, 2025 | Jun 13, 2025 | A · derivative | 10,350 | $32.33 | $334,616 | 10,350 | No | Form 4 |
| Nichols Weston | Jun 11, 2025 | Jun 13, 2025 | A | 6,900 | $0.00 | $0 | 16,300 | No | Form 4 |
| Nichols Weston | Jun 11, 2025 | Jun 13, 2025 | A · derivative | 10,350 | $32.33 | $334,616 | 10,350 | No | Form 4 |
| Bedrosian Camille L | Jun 11, 2025 | Jun 13, 2025 | A | 6,900 | $0.00 | $0 | 16,300 | No | Form 4 |
| Bedrosian Camille L | Jun 11, 2025 | Jun 13, 2025 | A · derivative | 10,350 | $32.33 | $334,616 | 10,350 | No | Form 4 |
| Fust Matthew K | Jun 11, 2025 | Jun 13, 2025 | A | 6,900 | $0.00 | $0 | 28,836 | No | Form 4 |
| Fust Matthew K | Jun 11, 2025 | Jun 13, 2025 | A · derivative | 10,350 | $32.33 | $334,616 | 10,350 | No | Form 4 |
| Okey Stephanie | Jun 11, 2025 | Jun 13, 2025 | A | 6,900 | $0.00 | $0 | 16,300 | No | Form 4 |
| Okey Stephanie | Jun 11, 2025 | Jun 13, 2025 | A · derivative | 10,350 | $32.33 | $334,616 | 10,350 | No | Form 4 |
| Vivaldi Coelho Rogerio | Jun 11, 2025 | Jun 13, 2025 | A | 6,900 | $0.00 | $0 | 21,300 | No | Form 4 |
| Vivaldi Coelho Rogerio | Jun 11, 2025 | Jun 13, 2025 | A · derivative | 10,350 | $32.33 | $334,616 | 10,350 | No | Form 4 |
| Deardorf Caren | Jun 11, 2025 | Jun 13, 2025 | A | 6,900 | $0.00 | $0 | 16,300 | No | Form 4 |
| Deardorf Caren | Jun 11, 2025 | Jun 13, 2025 | A · derivative | 10,350 | $32.33 | $334,616 | 10,350 | No | Form 4 |
| Struthers Richard ScottPresident & CEO | May 14, 2025 | May 16, 2025 | G | 90,400 | $0.00 | $0 | 320,017 | No | Form 4 |
| Struthers Richard ScottPresident & CEO | May 14, 2025 | May 16, 2025 | G | 90,400 | $0.00 | $0 | 661,205 | No | Form 4 |
| Struthers Richard ScottPresident & CEO | Apr 2, 2025 | Apr 4, 2025 | M | 81,270 | $1.91 | $155,226 | 410,417 | No | Form 4 |
| Struthers Richard ScottPresident & CEO | Apr 2, 2025 | Apr 4, 2025 | M · derivative | 81,270 | $1.91 | $155,226 | not reported | No | Form 4 |
| Struthers Richard ScottPresident & CEO | Mar 19, 2025 | Mar 21, 2025 | S | 16,463 | $34.17 | Sale −$562,541 | 330,022 | Yes | Form 4 |
| Struthers Richard ScottPresident & CEO | Mar 19, 2025 | Mar 21, 2025 | S | 875 | $34.83 | Sale −$30,476 | 329,147 | Yes | Form 4 |
| Betz Stephen F.Chief Scientific Officer | Mar 19, 2025 | Mar 21, 2025 | S | 5,479 | $34.17 | Sale −$187,217 | 108,879 | Yes | Form 4 |
| Betz Stephen F.Chief Scientific Officer | Mar 19, 2025 | Mar 21, 2025 | S | 291 | $34.83 | Sale −$10,136 | 108,588 | Yes | Form 4 |
| Knight Jeff E.Chief Operating Officer | Mar 19, 2025 | Mar 21, 2025 | S | 6,801 | $34.17 | Sale −$232,390 | 87,852 | Yes | Form 4 |
| Knight Jeff E.Chief Operating Officer | Mar 19, 2025 | Mar 21, 2025 | S | 361 | $34.83 | Sale −$12,574 | 87,491 | Yes | Form 4 |
| Pizzuti DanaChief Med and Dev Officer | Mar 19, 2025 | Mar 21, 2025 | S | 2,388 | $34.17 | Sale −$81,598 | 72,360 | Yes | Form 4 |
| Pizzuti DanaChief Med and Dev Officer | Mar 19, 2025 | Mar 21, 2025 | S | 127 | $34.83 | Sale −$4,423 | 72,233 | Yes | Form 4 |
| Schilke TobinChief Financial Officer | Mar 10, 2025 | Mar 11, 2025 | A | 52,000 | $0.00 | $0 | 52,000 | No | Form 4 |
| Schilke TobinChief Financial Officer | Mar 10, 2025 | Mar 11, 2025 | A · derivative | 80,000 | $33.75 | $2,700,000 | 80,000 | No | Form 4 |
| Betz Stephen F.Chief Scientific Officer | Feb 20, 2025 | Feb 24, 2025 | A | 43,000 | $0.00 | $0 | 114,358 | No | Form 4 |
| Betz Stephen F.Chief Scientific Officer | Feb 20, 2025 | Feb 24, 2025 | A · derivative | 65,000 | $36.86 | $2,395,900 | 65,000 | No | Form 4 |
| Pizzuti DanaChief Med and Dev Officer | Feb 20, 2025 | Feb 24, 2025 | A | 43,000 | $0.00 | $0 | 74,748 | No | Form 4 |
| Pizzuti DanaChief Med and Dev Officer | Feb 20, 2025 | Feb 24, 2025 | A · derivative | 65,000 | $36.86 | $2,395,900 | 65,000 | No | Form 4 |
| Knight Jeff E.Chief Operating Officer | Feb 20, 2025 | Feb 24, 2025 | A | 43,000 | $0.00 | $0 | 94,653 | No | Form 4 |
| Knight Jeff E.Chief Operating Officer | Feb 20, 2025 | Feb 24, 2025 | A · derivative | 65,000 | $36.86 | $2,395,900 | 65,000 | No | Form 4 |
| Struthers Richard ScottPresident & CEO | Feb 20, 2025 | Feb 24, 2025 | A | 89,000 | $0.00 | $0 | 346,485 | No | Form 4 |
| Struthers Richard ScottPresident & CEO | Feb 20, 2025 | Feb 24, 2025 | A · derivative | 313,000 | $36.86 | $11,537,180 | 313,000 | No | Form 4 |
| Pizzuti DanaChief Med and Dev Officer | Feb 3, 2025 | Feb 5, 2025 | M | 5,000 | $16.89 | $84,450 | 36,748 | Yes | Form 4 |
| Pizzuti DanaChief Med and Dev Officer | Feb 3, 2025 | Feb 5, 2025 | S | 5,000 | $39.07 | Sale −$195,350 | 31,748 | Yes | Form 4 |
| Pizzuti DanaChief Med and Dev Officer | Feb 3, 2025 | Feb 5, 2025 | M · derivative | 5,000 | $16.89 | $84,450 | 119,042 | Yes | Form 4 |
| Kalofonos IsabelChief Commercial Officer | Jan 10, 2025 | Jan 13, 2025 | A · derivative | 100,000 | $40.59 | $4,059,000 | 100,000 | No | Form 4 |
| Pizzuti DanaChief Med and Dev Officer | Jan 7, 2025 | Jan 7, 2025 | M | 2,500 | $19.64 | $49,100 | 31,748 | Yes | Form 4 |
| Pizzuti DanaChief Med and Dev Officer | Jan 7, 2025 | Jan 7, 2025 | M · derivative | 2,500 | $19.64 | $49,100 | 18,500 | Yes | Form 4 |
| Pizzuti DanaChief Med and Dev Officer | Jan 3, 2025 | Jan 7, 2025 | M | 15,000 | $16.89 | $253,350 | 44,248 | Yes | Form 4 |
| Pizzuti DanaChief Med and Dev Officer | Jan 3, 2025 | Jan 7, 2025 | S | 15,000 | $52.09 | Sale −$781,350 | 29,248 | Yes | Form 4 |
| Pizzuti DanaChief Med and Dev Officer | Jan 3, 2025 | Jan 7, 2025 | M · derivative | 15,000 | $16.89 | $253,350 | 124,042 | Yes | Form 4 |
| Betz Stephen F.Chief Scientific Officer | Dec 16, 2024 | Dec 18, 2024 | M | 2,331 | $1.91 | $4,452 | 71,358 | No | Form 4 |
| Betz Stephen F.Chief Scientific Officer | Dec 16, 2024 | Dec 18, 2024 | M · derivative | 2,331 | $1.91 | $4,452 | 180,039 | No | Form 4 |
| Struthers Richard ScottPresident & CEO | Dec 2, 2024 | Dec 4, 2024 | S | 10,000 | $57.57 | Sale −$575,700 | 100,000 | Yes | Form 4 |
| Knight Jeff E.Chief Operating Officer | Nov 22, 2024 | Nov 26, 2024 | S | 501 | $56.52 | Sale −$28,317 | 51,653 | Yes | Form 4 |
| Pizzuti DanaChief Med and Dev Officer | Oct 3, 2024 | Oct 7, 2024 | M | 14,375 | $16.89 | $242,794 | 42,882 | Yes | Form 4 |
| Pizzuti DanaChief Med and Dev Officer | Oct 3, 2024 | Oct 7, 2024 | S | 14,375 | $54.63 | Sale −$785,306 | 28,507 | Yes | Form 4 |
| Pizzuti DanaChief Med and Dev Officer | Oct 3, 2024 | Oct 7, 2024 | M · derivative | 14,375 | $16.89 | $242,794 | 139,042 | Yes | Form 4 |
| Wilson MarcCFO | Sep 26, 2024 | Sep 30, 2024 | M | 25,000 | $15.29 | $382,250 | 136,092 | Yes | Form 4 |
| Wilson MarcCFO | Sep 26, 2024 | Sep 30, 2024 | S | 25,000 | $51.11 | Sale −$1,277,750 | 111,092 | Yes | Form 4 |
| Wilson MarcCFO | Sep 26, 2024 | Sep 30, 2024 | M · derivative | 25,000 | $15.29 | $382,250 | 89,000 | Yes | Form 4 |
| Betz Stephen F.Chief Scientific Officer | Sep 10, 2024 | Sep 12, 2024 | S | 1,035 | $51.50 | Sale −$53,303 | 68,576 | Yes | Form 4 |
| Betz Stephen F.Chief Scientific Officer | Aug 26, 2024 | Aug 28, 2024 | S | 3,000 | $53.19 | Sale −$159,570 | 69,611 | Yes | Form 4 |
| Betz Stephen F.Chief Scientific Officer | Aug 12, 2024 | Aug 14, 2024 | S | 3,000 | $47.68 | Sale −$143,040 | 72,611 | Yes | Form 4 |
| Wilson MarcCFO | Jul 25, 2024 | Jul 26, 2024 | M | 19,056 | $9.28 | $176,840 | 130,148 | Yes | Form 4 |
| Wilson MarcCFO | Jul 25, 2024 | Jul 26, 2024 | S | 19,056 | $53.88 | Sale −$1,026,737 | 111,092 | Yes | Form 4 |
| Wilson MarcCFO | Jul 25, 2024 | Jul 26, 2024 | M · derivative | 19,056 | $9.28 | $176,840 | not reported | Yes | Form 4 |
| Betz Stephen F.Chief Scientific Officer | Jul 25, 2024 | Jul 26, 2024 | S | 3,000 | $53.43 | Sale −$160,290 | 75,611 | Yes | Form 4 |
| Wilson MarcCFO | Jul 15, 2024 | Jul 17, 2024 | M | 25,000 | $20.02 | $500,500 | 136,092 | Yes | Form 4 |
| Wilson MarcCFO | Jul 15, 2024 | Jul 17, 2024 | S | 25,000 | $55.00 | Sale −$1,375,000 | 111,092 | Yes | Form 4 |
| Wilson MarcCFO | Jul 15, 2024 | Jul 17, 2024 | M · derivative | 25,000 | $20.02 | $500,500 | 66,000 | Yes | Form 4 |
| Knight Jeff E.Chief Operating Officer | Jul 15, 2024 | Jul 17, 2024 | M | 17,499 | $23.98 | $419,626 | 70,079 | Yes | Form 4 |
| Knight Jeff E.Chief Operating Officer | Jul 15, 2024 | Jul 17, 2024 | M | 2,887 | $20.02 | $57,798 | 72,966 | Yes | Form 4 |
| Knight Jeff E.Chief Operating Officer | Jul 15, 2024 | Jul 17, 2024 | M | 5,687 | $19.64 | $111,693 | 78,653 | Yes | Form 4 |
| Knight Jeff E.Chief Operating Officer | Jul 15, 2024 | Jul 17, 2024 | S | 27,000 | $55.00 | Sale −$1,485,000 | 51,653 | Yes | Form 4 |
| Knight Jeff E.Chief Operating Officer | Jul 15, 2024 | Jul 17, 2024 | M · derivative | 17,499 | $23.98 | $419,626 | 112,501 | Yes | Form 4 |
| Knight Jeff E.Chief Operating Officer | Jul 15, 2024 | Jul 17, 2024 | M · derivative | 2,887 | $20.02 | $57,798 | 20,213 | Yes | Form 4 |
| Knight Jeff E.Chief Operating Officer | Jul 15, 2024 | Jul 17, 2024 | M · derivative | 5,687 | $19.64 | $111,693 | 85,313 | Yes | Form 4 |
| Betz Stephen F.Chief Scientific Officer | Jul 10, 2024 | Jul 12, 2024 | S | 3,000 | $48.55 | Sale −$145,650 | 78,611 | Yes | Form 4 |
| Hassard JamesChief Commercial Officer | Jul 5, 2024 | Jul 9, 2024 | M | 15,000 | $19.73 | $295,950 | 44,259 | Yes | Form 4 |
| Hassard JamesChief Commercial Officer | Jul 5, 2024 | Jul 9, 2024 | S | 15,000 | $44.08 | Sale −$661,200 | 29,259 | Yes | Form 4 |
| Hassard JamesChief Commercial Officer | Jul 5, 2024 | Jul 9, 2024 | M · derivative | 15,000 | $19.73 | $295,950 | 130,000 | Yes | Form 4 |
| Pizzuti DanaChief Med and Dev Officer | Jul 3, 2024 | Jul 5, 2024 | M | 14,375 | $16.89 | $242,794 | 42,882 | Yes | Form 4 |
| Pizzuti DanaChief Med and Dev Officer | Jul 3, 2024 | Jul 5, 2024 | S | 14,375 | $44.87 | Sale −$645,006 | 28,507 | Yes | Form 4 |
| Pizzuti DanaChief Med and Dev Officer | Jul 3, 2024 | Jul 5, 2024 | M · derivative | 14,375 | $16.89 | $242,794 | 153,417 | Yes | Form 4 |
| Wilson MarcCFO | Jun 28, 2024 | Jul 2, 2024 | M | 32,129 | $9.28 | $298,157 | 143,221 | Yes | Form 4 |
| Wilson MarcCFO | Jun 28, 2024 | Jul 2, 2024 | S | 32,129 | $43.61 | Sale −$1,401,146 | 111,092 | Yes | Form 4 |
| Wilson MarcCFO | Jun 28, 2024 | Jul 2, 2024 | M · derivative | 32,129 | $9.28 | $298,157 | 19,056 | Yes | Form 4 |
| Knight Jeff E.Chief Operating Officer | Jun 26, 2024 | Jun 28, 2024 | S | 956 | $44.38 | Sale −$42,427 | 52,580 | Yes | Form 4 |
| Betz Stephen F.Chief Scientific Officer | Jun 25, 2024 | Jun 26, 2024 | S | 3,000 | $45.37 | Sale −$136,110 | 80,643 | Yes | Form 4 |
| Pizzuti DanaChief Med and Dev Officer | Jun 24, 2024 | Jun 25, 2024 | M | 9,500 | $16.89 | $160,455 | 37,286 | No | Form 4 |
| Pizzuti DanaChief Med and Dev Officer | Jun 24, 2024 | Jun 25, 2024 | S | 9,500 | $45.73 | Sale −$434,435 | 27,786 | No | Form 4 |
| Pizzuti DanaChief Med and Dev Officer | Jun 24, 2024 | Jun 25, 2024 | M · derivative | 9,500 | $19.73 | $187,435 | 167,792 | No | Form 4 |
| Hassard JamesChief Commercial Officer | Jun 21, 2024 | Jun 24, 2024 | M | 15,000 | $19.73 | $295,950 | 44,259 | Yes | Form 4 |
| Hassard JamesChief Commercial Officer | Jun 21, 2024 | Jun 24, 2024 | S | 15,000 | $44.66 | Sale −$669,900 | 29,259 | Yes | Form 4 |
| Hassard JamesChief Commercial Officer | Jun 21, 2024 | Jun 24, 2024 | M · derivative | 15,000 | $19.73 | $295,950 | 145,000 | Yes | Form 4 |
| Betz Stephen F.Chief Scientific Officer | Jun 10, 2024 | Jun 11, 2024 | S | 3,000 | $43.86 | Sale −$131,580 | 83,643 | Yes | Form 4 |
| Wierenga Wendall | Jun 7, 2024 | Jun 11, 2024 | A | 3,400 | $0.00 | $0 | 109,246 | No | Form 4 |
| Wierenga Wendall | Jun 7, 2024 | Jun 11, 2024 | A · derivative | 12,500 | $44.71 | $558,875 | 12,500 | No | Form 4 |
| Bedrosian Camille L | Jun 7, 2024 | Jun 11, 2024 | A | 3,400 | $0.00 | $0 | 9,400 | No | Form 4 |
| Bedrosian Camille L | Jun 7, 2024 | Jun 11, 2024 | A · derivative | 12,500 | $44.71 | $558,875 | 12,500 | No | Form 4 |
| Fust Matthew K | Jun 7, 2024 | Jun 11, 2024 | A | 3,400 | $0.00 | $0 | 21,936 | No | Form 4 |
| Fust Matthew K | Jun 7, 2024 | Jun 11, 2024 | A · derivative | 12,500 | $44.71 | $558,875 | 12,500 | No | Form 4 |
| Nichols Weston | Jun 7, 2024 | Jun 11, 2024 | A | 3,400 | $0.00 | $0 | 9,400 | No | Form 4 |
| Nichols Weston | Jun 7, 2024 | Jun 11, 2024 | A · derivative | 12,500 | $44.71 | $558,875 | 12,500 | No | Form 4 |
| Okey Stephanie | Jun 7, 2024 | Jun 11, 2024 | A | 3,400 | $0.00 | $0 | 9,400 | No | Form 4 |
| Okey Stephanie | Jun 7, 2024 | Jun 11, 2024 | A · derivative | 12,500 | $44.71 | $558,875 | 12,500 | No | Form 4 |
| Vivaldi Coelho Rogerio | Jun 7, 2024 | Jun 11, 2024 | A | 3,400 | $0.00 | $0 | 14,400 | No | Form 4 |
| Vivaldi Coelho Rogerio | Jun 7, 2024 | Jun 11, 2024 | A · derivative | 12,500 | $44.71 | $558,875 | 12,500 | No | Form 4 |
| Deardorf Caren | Jun 7, 2024 | Jun 11, 2024 | A | 3,400 | $0.00 | $0 | 9,400 | No | Form 4 |
| Deardorf Caren | Jun 7, 2024 | Jun 11, 2024 | A · derivative | 12,500 | $44.71 | $558,875 | 12,500 | No | Form 4 |
| Betz Stephen F.Chief Scientific Officer | May 28, 2024 | May 30, 2024 | S | 3,000 | $47.49 | Sale −$142,470 | 86,643 | Yes | Form 4 |
| Betz Stephen F.Chief Scientific Officer | May 10, 2024 | May 14, 2024 | S | 3,000 | $49.43 | Sale −$148,290 | 89,643 | Yes | Form 4 |
| Struthers Richard ScottPresident & CEO | May 8, 2024 | May 10, 2024 | M | 107,448 | $9.28 | $997,117 | 364,933 | Yes | Form 4 |
| Struthers Richard ScottPresident & CEO | May 8, 2024 | May 10, 2024 | S | 107,448 | $49.40 | Sale −$5,307,931 | 257,485 | Yes | Form 4 |
| Struthers Richard ScottPresident & CEO | May 8, 2024 | May 10, 2024 | M · derivative | 107,448 | $9.28 | $997,117 | 16,342 | Yes | Form 4 |
| Struthers Richard ScottPresident & CEO | Apr 18, 2024 | Apr 22, 2024 | G | 350 | $0.00 | $0 | 257,485 | No | Form 4 |
| Struthers Richard ScottPresident & CEO | Apr 15, 2024 | Apr 17, 2024 | M | 20,000 | $1.91 | $38,200 | 257,835 | No | Form 4 |
| Struthers Richard ScottPresident & CEO | Apr 15, 2024 | Apr 17, 2024 | M · derivative | 20,000 | $1.91 | $38,200 | 81,270 | No | Form 4 |
| Pizzuti DanaChief Med and Dev Officer | Apr 15, 2024 | Apr 17, 2024 | M | 14,375 | $16.89 | $242,794 | 42,161 | Yes | Form 4 |
| Pizzuti DanaChief Med and Dev Officer | Apr 15, 2024 | Apr 17, 2024 | S | 14,375 | $44.47 | Sale −$639,256 | 27,786 | Yes | Form 4 |
| Pizzuti DanaChief Med and Dev Officer | Apr 15, 2024 | Apr 17, 2024 | M · derivative | 14,375 | $16.89 | $242,794 | 177,292 | Yes | Form 4 |
| Struthers Richard ScottPresident & CEO | Apr 4, 2024 | Apr 8, 2024 | M | 40,951 | $9.28 | $380,025 | 278,786 | Yes | Form 4 |
| Struthers Richard ScottPresident & CEO | Apr 4, 2024 | Apr 8, 2024 | S | 40,951 | $49.17 | Sale −$2,013,561 | 237,835 | Yes | Form 4 |
| Struthers Richard ScottPresident & CEO | Apr 4, 2024 | Apr 8, 2024 | M · derivative | 40,951 | $9.28 | $380,025 | 123,790 | Yes | Form 4 |
| Okey Stephanie | Mar 28, 2024 | Apr 2, 2024 | M | 17,500 | $18.29 | $320,075 | 23,500 | No | Form 4 |
| Okey Stephanie | Mar 28, 2024 | Apr 2, 2024 | S | 17,500 | $46.38 | Sale −$811,650 | 6,000 | No | Form 4 |
| Okey Stephanie | Mar 28, 2024 | Apr 2, 2024 | M · derivative | 17,500 | $18.29 | $320,075 | not reported | No | Form 4 |
| Knight Jeff E.Chief Operating Officer | Mar 22, 2024 | Mar 26, 2024 | M | 30,000 | $23.98 | $719,400 | 84,939 | No | Form 4 |
| Knight Jeff E.Chief Operating Officer | Mar 22, 2024 | Mar 26, 2024 | S | 30,000 | $44.22 | Sale −$1,326,600 | 54,939 | No | Form 4 |
| Knight Jeff E.Chief Operating Officer | Mar 22, 2024 | Mar 26, 2024 | S | 2,359 | $45.39 | Sale −$107,075 | 52,580 | No | Form 4 |
| Knight Jeff E.Chief Operating Officer | Mar 22, 2024 | Mar 26, 2024 | M · derivative | 30,000 | $23.98 | $719,400 | 130,000 | No | Form 4 |
| Fust Matthew K | Mar 20, 2024 | Mar 22, 2024 | M | 12,500 | $23.24 | $290,500 | 31,036 | Yes | Form 4 |
| Fust Matthew K | Mar 20, 2024 | Mar 22, 2024 | S | 12,500 | $43.57 | Sale −$544,625 | 18,536 | Yes | Form 4 |
| Fust Matthew K | Mar 20, 2024 | Mar 22, 2024 | M | 12,500 | $23.23 | $290,375 | 31,036 | Yes | Form 4 |
| Fust Matthew K | Mar 20, 2024 | Mar 22, 2024 | S | 12,500 | $43.57 | Sale −$544,625 | 18,536 | Yes | Form 4 |
| Fust Matthew K | Mar 20, 2024 | Mar 22, 2024 | M | 17,500 | $20.23 | $354,025 | 36,036 | Yes | Form 4 |
| Fust Matthew K | Mar 20, 2024 | Mar 22, 2024 | S | 17,500 | $43.58 | Sale −$762,650 | 18,536 | Yes | Form 4 |
| Fust Matthew K | Mar 20, 2024 | Mar 22, 2024 | M | 17,500 | $18.29 | $320,075 | 36,036 | Yes | Form 4 |
| Fust Matthew K | Mar 20, 2024 | Mar 22, 2024 | S | 17,500 | $45.50 | Sale −$796,250 | 18,536 | Yes | Form 4 |
| Fust Matthew K | Mar 20, 2024 | Mar 22, 2024 | M · derivative | 12,500 | $23.24 | $290,500 | not reported | Yes | Form 4 |
| Fust Matthew K | Mar 20, 2024 | Mar 22, 2024 | M · derivative | 12,500 | $23.23 | $290,375 | not reported | Yes | Form 4 |
| Fust Matthew K | Mar 20, 2024 | Mar 22, 2024 | M · derivative | 17,500 | $20.23 | $354,025 | not reported | Yes | Form 4 |
| Fust Matthew K | Mar 20, 2024 | Mar 22, 2024 | M · derivative | 17,500 | $18.29 | $320,075 | not reported | Yes | Form 4 |
| Pizzuti DanaChief Med and Dev Officer | Mar 20, 2024 | Mar 22, 2024 | M | 4,375 | $16.89 | $73,894 | 32,875 | No | Form 4 |
| Pizzuti DanaChief Med and Dev Officer | Mar 20, 2024 | Mar 22, 2024 | S | 4,375 | $45.89 | Sale −$200,769 | 28,500 | No | Form 4 |
| Pizzuti DanaChief Med and Dev Officer | Mar 20, 2024 | Mar 22, 2024 | M | 10,000 | $16.89 | $168,900 | 38,500 | No | Form 4 |
| Pizzuti DanaChief Med and Dev Officer | Mar 20, 2024 | Mar 22, 2024 | S | 10,000 | $43.28 | Sale −$432,800 | 28,500 | No | Form 4 |
| Pizzuti DanaChief Med and Dev Officer | Mar 20, 2024 | Mar 22, 2024 | S | 714 | $43.69 | Sale −$31,195 | 27,786 | No | Form 4 |
| Pizzuti DanaChief Med and Dev Officer | Mar 20, 2024 | Mar 22, 2024 | M · derivative | 4,375 | $16.89 | $73,894 | 201,667 | No | Form 4 |
| Pizzuti DanaChief Med and Dev Officer | Mar 20, 2024 | Mar 22, 2024 | M · derivative | 10,000 | $16.89 | $168,900 | 191,667 | No | Form 4 |
| Wilson MarcCFO | Mar 19, 2024 | Mar 20, 2024 | S | 6,942 | $42.91 | Sale −$297,881 | 110,630 | Yes | Form 4 |
| Struthers Richard ScottPresident & CEO | Mar 18, 2024 | Mar 20, 2024 | F | 12,687 | $38.14 | $483,882 | 237,835 | Yes | Form 4 |
| Wilson MarcCFO | Mar 18, 2024 | Mar 20, 2024 | F | 3,983 | $38.14 | $151,912 | 117,572 | Yes | Form 4 |
| Betz Stephen F.Chief Scientific Officer | Mar 18, 2024 | Mar 20, 2024 | F | 3,655 | $38.14 | $139,402 | 92,643 | Yes | Form 4 |
| Hassard JamesChief Commercial Officer | Mar 18, 2024 | Mar 20, 2024 | F | 1,741 | $38.14 | $66,402 | 29,259 | Yes | Form 4 |
| Knight Jeff E.Chief Operating Officer | Mar 18, 2024 | Mar 20, 2024 | F | 4,283 | $38.14 | $163,354 | 54,939 | Yes | Form 4 |
| Pizzuti DanaChief Med and Dev Officer | Mar 18, 2024 | Mar 20, 2024 | F | 411 | $38.14 | $15,676 | 28,500 | Yes | Form 4 |
| Betz Stephen F.Chief Scientific Officer | Mar 4, 2024 | Mar 6, 2024 | A | 23,000 | $0.00 | $0 | 96,298 | No | Form 4 |
| Betz Stephen F.Chief Scientific Officer | Mar 4, 2024 | Mar 6, 2024 | A · derivative | 87,000 | $43.51 | $3,785,370 | 87,000 | No | Form 4 |
| Knight Jeff E.Chief Operating Officer | Mar 4, 2024 | Mar 6, 2024 | A | 23,000 | $0.00 | $0 | 59,222 | No | Form 4 |
| Knight Jeff E.Chief Operating Officer | Mar 4, 2024 | Mar 6, 2024 | A · derivative | 87,000 | $43.51 | $3,785,370 | 87,000 | No | Form 4 |
| Pizzuti DanaChief Med and Dev Officer | Mar 4, 2024 | Mar 6, 2024 | A | 23,000 | $0.00 | $0 | 28,911 | No | Form 4 |
| Pizzuti DanaChief Med and Dev Officer | Mar 4, 2024 | Mar 6, 2024 | A · derivative | 87,000 | $43.51 | $3,785,370 | 87,000 | No | Form 4 |
| Struthers Richard ScottPresident & CEO | Mar 4, 2024 | Mar 6, 2024 | A | 65,000 | $0.00 | $0 | 250,522 | No | Form 4 |
| Struthers Richard ScottPresident & CEO | Mar 4, 2024 | Mar 6, 2024 | A · derivative | 240,000 | $43.51 | $10,442,400 | 240,000 | No | Form 4 |
| Wilson MarcCFO | Mar 4, 2024 | Mar 6, 2024 | A | 25,500 | $0.00 | $0 | 121,555 | No | Form 4 |
| Wilson MarcCFO | Mar 4, 2024 | Mar 6, 2024 | A · derivative | 95,500 | $43.51 | $4,155,205 | 95,500 | No | Form 4 |
| Hassard JamesChief Commercial Officer | Mar 4, 2024 | Mar 6, 2024 | A | 17,000 | $0.00 | $0 | 31,000 | No | Form 4 |
| Hassard JamesChief Commercial Officer | Mar 4, 2024 | Mar 6, 2024 | A · derivative | 63,000 | $43.51 | $2,741,130 | 63,000 | No | Form 4 |
| Struthers Richard ScottPresident & CEO | Feb 12, 2024 | Feb 14, 2024 | G | 60,000 | $0.00 | $0 | 570,805 | No | Form 4 |
| Struthers Richard ScottPresident & CEO | Feb 12, 2024 | Feb 14, 2024 | G | 20,000 | $0.00 | $0 | 110,000 | No | Form 4 |
| Struthers Richard ScottPresident & CEO | Feb 12, 2024 | Feb 14, 2024 | G | 20,000 | $0.00 | $0 | 110,000 | No | Form 4 |
| Struthers Richard ScottPresident & CEO | Feb 12, 2024 | Feb 14, 2024 | G | 20,000 | $0.00 | $0 | 110,000 | No | Form 4 |
| Betz Stephen F.Chief Scientific Officer | Jan 25, 2024 | Jan 26, 2024 | S | 3,000 | $37.26 | Sale −$111,780 | 73,298 | Yes | Form 4 |
| Betz Stephen F.Chief Scientific Officer | Jan 10, 2024 | Jan 12, 2024 | S | 3,000 | $37.65 | Sale −$112,950 | 76,298 | Yes | Form 4 |
| Pizzuti DanaChief Med and Dev Officer | Jan 3, 2024 | Jan 4, 2024 | M | 14,375 | $16.89 | $242,794 | 20,286 | Yes | Form 4 |
| Pizzuti DanaChief Med and Dev Officer | Jan 3, 2024 | Jan 4, 2024 | S | 14,375 | $35.00 | Sale −$503,125 | 5,911 | Yes | Form 4 |
| Pizzuti DanaChief Med and Dev Officer | Jan 3, 2024 | Jan 4, 2024 | M · derivative | 14,375 | $16.89 | $242,794 | 206,042 | Yes | Form 4 |
| Wilson MarcCFO | Jan 2, 2024 | Jan 4, 2024 | M | 10,000 | $9.28 | $92,800 | 106,055 | Yes | Form 4 |
| Wilson MarcCFO | Jan 2, 2024 | Jan 4, 2024 | S | 10,000 | $35.47 | Sale −$354,700 | 96,055 | Yes | Form 4 |
| Wilson MarcCFO | Jan 2, 2024 | Jan 4, 2024 | M · derivative | 10,000 | $9.28 | $92,800 | 51,185 | Yes | Form 4 |
| Betz Stephen F.Chief Scientific Officer | Dec 26, 2023 | Dec 27, 2023 | S | 3,000 | $35.89 | Sale −$107,670 | 79,298 | Yes | Form 4 |
| Pizzuti DanaChief Med and Dev Officer | Dec 21, 2023 | Dec 22, 2023 | M | 9,583 | $16.89 | $161,857 | 15,494 | No | Form 4 |
| Pizzuti DanaChief Med and Dev Officer | Dec 21, 2023 | Dec 22, 2023 | S | 9,583 | $34.57 | Sale −$331,284 | 5,911 | No | Form 4 |
| Pizzuti DanaChief Med and Dev Officer | Dec 21, 2023 | Dec 22, 2023 | M · derivative | 9,583 | $16.89 | $161,857 | 220,417 | No | Form 4 |
| Betz Stephen F.Chief Scientific Officer | Dec 11, 2023 | Dec 13, 2023 | S | 3,000 | $32.87 | Sale −$98,610 | 82,298 | Yes | Form 4 |
| Betz Stephen F.Chief Scientific Officer | Nov 27, 2023 | Nov 29, 2023 | S | 3,000 | $31.84 | Sale −$95,520 | 85,298 | Yes | Form 4 |
| Struthers Richard ScottPresident & CEO | Nov 9, 2023 | Nov 13, 2023 | M | 50,000 | $1.91 | $95,500 | 185,522 | No | Form 4 |
| Struthers Richard ScottPresident & CEO | Nov 9, 2023 | Nov 13, 2023 | M · derivative | 50,000 | $1.91 | $95,500 | 101,270 | No | Form 4 |
| Struthers Richard ScottPresident & CEO | Nov 3, 2023 | Nov 6, 2023 | M | 199,082 | $9.28 | $1,847,481 | 334,604 | Yes | Form 4 |
| Struthers Richard ScottPresident & CEO | Nov 3, 2023 | Nov 6, 2023 | S | 199,082 | $30.56 | Sale −$6,083,946 | 135,522 | Yes | Form 4 |
| Struthers Richard ScottPresident & CEO | Nov 3, 2023 | Nov 6, 2023 | M · derivative | 199,082 | $9.28 | $1,847,481 | 164,741 | Yes | Form 4 |
| Struthers Richard ScottPresident & CEO | Nov 2, 2023 | Nov 6, 2023 | M | 918 | $9.28 | $8,519 | 136,440 | Yes | Form 4 |
| Struthers Richard ScottPresident & CEO | Nov 2, 2023 | Nov 6, 2023 | S | 918 | $29.95 | Sale −$27,494 | 135,522 | Yes | Form 4 |
| Struthers Richard ScottPresident & CEO | Nov 2, 2023 | Nov 6, 2023 | M · derivative | 918 | $9.28 | $8,519 | 363,823 | Yes | Form 4 |
| Wilson MarcCFO | Nov 1, 2023 | Nov 3, 2023 | M | 10,000 | $9.28 | $92,800 | 105,601 | Yes | Form 4 |
| Wilson MarcCFO | Nov 1, 2023 | Nov 3, 2023 | S | 10,000 | $28.75 | Sale −$287,500 | 95,601 | Yes | Form 4 |
| Wilson MarcCFO | Nov 1, 2023 | Nov 3, 2023 | M · derivative | 10,000 | $9.28 | $92,800 | 61,185 | Yes | Form 4 |
| Krasner Alan SethChief Medical Officer | Oct 17, 2023 | Oct 19, 2023 | M | 7,000 | $12.01 | $84,070 | 50,210 | Yes | Form 4 |
| Krasner Alan SethChief Medical Officer | Oct 17, 2023 | Oct 19, 2023 | S | 7,000 | $30.00 | Sale −$210,000 | 43,210 | Yes | Form 4 |
| Krasner Alan SethChief Medical Officer | Oct 17, 2023 | Oct 19, 2023 | M · derivative | 7,000 | $12.01 | $84,070 | 153,473 | Yes | Form 4 |