CYTKCYTOKINETICS INC
- Market cap
- $8.51B
- as of 2026-10-23
- Latest close
- $61.23
- as of 2026-10-23
- Sector
- Healthcare
- as of 2026-10-24
- Industry
- Biotechnology
- as of 2026-10-24
Cluster
No cluster in the last 90 days under the default rule (14d · ≥2 insiders · all roles).
Form 4 historysince 2023-10-03
Showing the latest 500 of 740 transactions.
| Insider | Traded | Filed | Type | Shares | Price | Value | Owned after | 10b5-1 plan | Filing |
|---|---|---|---|---|---|---|---|---|---|
| Malik Fady IbrahamEVP Research & Development | Oct 20 | Oct 20 | M | 3,500 | $7.80 | $27,300 | 157,402 | Yes | Form 4 |
| Malik Fady IbrahamEVP Research & Development | Oct 20 | Oct 20 | S | 3,500 | $64.01 | Sale −$224,035 | 153,902 | Yes | Form 4 |
| Malik Fady IbrahamEVP Research & Development | Oct 20 | Oct 20 | M · derivative | 3,500 | $7.80 | $27,300 | 16,386 | Yes | Form 4 |
| Henderson John T | Oct 16 | Oct 20 | A | 352 | $63.92 | $22,500 | 78,712 | No | Form 4 |
| Wysenski Nancy | Oct 16 | Oct 20 | A | 97 | $63.92 | $6,200 | 34,089 | No | Form 4 |
| Kaye Edward M. MD | Oct 16 | Oct 20 | A | 195 | $63.92 | $12,464 | 10,629 | No | Form 4 |
| Harrington Robert Arthur | Oct 16 | Oct 20 | A | 195 | $63.92 | $12,464 | 22,127 | No | Form 4 |
| Daly James M | Oct 16 | Oct 20 | A | 195 | $63.92 | $12,464 | 3,585 | No | Form 4 |
| Wierenga Wendell | Oct 16 | Oct 20 | A | 97 | $63.92 | $6,200 | 35,660 | No | Form 4 |
| Blum Robert IPresident & CEO | Oct 12 | Oct 13 | M | 7,500 | $10.60 | $79,500 | 286,044 | Yes | Form 4 |
| Blum Robert IPresident & CEO | Oct 12 | Oct 13 | S | 7,500 | $62.88 | Sale −$471,600 | 278,544 | Yes | Form 4 |
| Blum Robert IPresident & CEO | Oct 12 | Oct 13 | M · derivative | 7,500 | $10.60 | $79,500 | 141,745 | Yes | Form 4 |
| Malik Fady IbrahamEVP Research & Development | Oct 6 | Oct 6 | M | 3,500 | $7.80 | $27,300 | 157,402 | Yes | Form 4 |
| Malik Fady IbrahamEVP Research & Development | Oct 6 | Oct 6 | S | 3,500 | $61.38 | Sale −$214,830 | 153,902 | Yes | Form 4 |
| Malik Fady IbrahamEVP Research & Development | Oct 6 | Oct 6 | M · derivative | 3,500 | $7.80 | $27,300 | 19,886 | Yes | Form 4 |
| Blum Robert IPresident & CEO | Sep 28 | Sep 28 | M | 7,500 | $10.60 | $79,500 | 286,044 | Yes | Form 4 |
| Blum Robert IPresident & CEO | Sep 28 | Sep 28 | S | 7,500 | $65.46 | Sale −$490,950 | 278,544 | Yes | Form 4 |
| Blum Robert IPresident & CEO | Sep 28 | Sep 28 | M · derivative | 7,500 | $10.60 | $79,500 | 149,245 | Yes | Form 4 |
| Malik Fady IbrahamEVP Research & Development | Sep 22 | Sep 22 | M | 3,500 | $7.80 | $27,300 | 157,402 | Yes | Form 4 |
| Malik Fady IbrahamEVP Research & Development | Sep 22 | Sep 22 | S | 3,500 | $68.29 | Sale −$239,015 | 153,902 | Yes | Form 4 |
| Malik Fady IbrahamEVP Research & Development | Sep 22 | Sep 22 | M · derivative | 3,500 | $7.80 | $27,300 | 23,386 | Yes | Form 4 |
| Blum Robert IPresident & CEO | Sep 15 | Sep 15 | S | 97,926 | $69.33 | Sale −$6,789,210 | not reported | Yes | Form 4 |
| Landry Robert E | Sep 15 | Sep 15 | S | 1,000 | $72.13 | Sale −$72,130 | 8,184 | Yes | Form 4 |
| Blum Robert IPresident & CEO | Sep 14 | Sep 15 | M | 7,500 | $10.60 | $79,500 | 385,320 | Yes | Form 4 |
| Blum Robert IPresident & CEO | Sep 14 | Sep 15 | S | 7,500 | $73.44 | Sale −$550,800 | 377,820 | Yes | Form 4 |
| Blum Robert IPresident & CEO | Sep 14 | Sep 15 | G | 1,350 | $0.00 | $0 | 376,470 | Yes | Form 4 |
| Blum Robert IPresident & CEO | Sep 14 | Sep 15 | G | 97,926 | $0.00 | $0 | 278,544 | Yes | Form 4 |
| Blum Robert IPresident & CEO | Sep 14 | Sep 15 | G | 97,926 | $0.00 | $0 | 97,926 | Yes | Form 4 |
| Blum Robert IPresident & CEO | Sep 14 | Sep 15 | M · derivative | 7,500 | $10.60 | $79,500 | 156,745 | Yes | Form 4 |
| Landry Robert E | Sep 11 | Sep 11 | S | 1,000 | $74.66 | Sale −$74,660 | 9,184 | Yes | Form 4 |
| Malik Fady IbrahamEVP Research & Development | Sep 8 | Sep 8 | M | 3,500 | $7.80 | $27,300 | 157,402 | Yes | Form 4 |
| Malik Fady IbrahamEVP Research & Development | Sep 8 | Sep 8 | S | 3,500 | $75.46 | Sale −$264,110 | 153,902 | Yes | Form 4 |
| Malik Fady IbrahamEVP Research & Development | Sep 8 | Sep 8 | M · derivative | 3,500 | $7.80 | $27,300 | 26,886 | Yes | Form 4 |
| Parshall B Lynne | Sep 1 | Sep 1 | S | 5,000 | $71.48 | Sale −$357,400 | 10,784 | Yes | Form 4 |
| Blum Robert IPresident & CEO | Aug 31 | Aug 31 | M | 7,500 | $10.60 | $79,500 | 385,320 | Yes | Form 4 |
| Blum Robert IPresident & CEO | Aug 31 | Aug 31 | S | 7,500 | $70.24 | Sale −$526,800 | 377,820 | Yes | Form 4 |
| Blum Robert IPresident & CEO | Aug 31 | Aug 31 | M · derivative | 7,500 | $10.60 | $79,500 | 164,245 | Yes | Form 4 |
| Callos AndrewEVP, Chief Commercial Officer | Aug 31 | Aug 31 | M | 10,000 | $23.26 | $232,600 | 68,555 | Yes | Form 4 |
| Callos AndrewEVP, Chief Commercial Officer | Aug 31 | Aug 31 | S | 10,000 | $70.24 | Sale −$702,400 | 58,555 | Yes | Form 4 |
| Callos AndrewEVP, Chief Commercial Officer | Aug 31 | Aug 31 | M · derivative | 10,000 | $23.26 | $232,600 | not reported | Yes | Form 4 |
| Malik Fady IbrahamEVP Research & Development | Aug 18 | Aug 18 | M | 3,500 | $7.80 | $27,300 | 157,402 | Yes | Form 4 |
| Malik Fady IbrahamEVP Research & Development | Aug 18 | Aug 18 | S | 3,500 | $75.82 | Sale −$265,370 | 153,902 | Yes | Form 4 |
| Malik Fady IbrahamEVP Research & Development | Aug 18 | Aug 18 | M · derivative | 3,500 | $7.80 | $27,300 | 30,386 | Yes | Form 4 |
| Blum Robert IPresident & CEO | Aug 10 | Aug 10 | M | 7,500 | $10.60 | $79,500 | 385,320 | Yes | Form 4 |
| Blum Robert IPresident & CEO | Aug 10 | Aug 10 | S | 7,500 | $76.76 | Sale −$575,700 | 377,820 | Yes | Form 4 |
| Blum Robert IPresident & CEO | Aug 10 | Aug 10 | M · derivative | 7,500 | $10.60 | $79,500 | 171,745 | Yes | Form 4 |
| Callos AndrewEVP, Chief Commercial Officer | Jul 30 | Jul 30 | M | 14,000 | $23.26 | $325,640 | 72,555 | Yes | Form 4 |
| Callos AndrewEVP, Chief Commercial Officer | Jul 30 | Jul 30 | S | 14,000 | $79.88 | Sale −$1,118,320 | 58,555 | Yes | Form 4 |
| Callos AndrewEVP, Chief Commercial Officer | Jul 30 | Jul 30 | M · derivative | 14,000 | $23.26 | $325,640 | 10,000 | Yes | Form 4 |
| Blum Robert IPresident & CEO | Jul 27 | Jul 27 | M | 7,500 | $10.60 | $79,500 | 385,320 | Yes | Form 4 |
| Blum Robert IPresident & CEO | Jul 27 | Jul 27 | S | 7,500 | $80.87 | Sale −$606,525 | 377,820 | Yes | Form 4 |
| Blum Robert IPresident & CEO | Jul 27 | Jul 27 | M · derivative | 7,500 | $10.60 | $79,500 | 179,245 | Yes | Form 4 |
| Malik Fady IbrahamEVP Research & Development | Jul 21 | Jul 23 | M | 3,500 | $7.80 | $27,300 | 157,402 | Yes | Form 4 |
| Malik Fady IbrahamEVP Research & Development | Jul 21 | Jul 23 | S | 3,500 | $80.59 | Sale −$282,065 | 153,902 | Yes | Form 4 |
| Malik Fady IbrahamEVP Research & Development | Jul 21 | Jul 23 | M · derivative | 3,500 | $7.80 | $27,300 | 33,886 | Yes | Form 4 |
| Daly James M | Jul 15 | Jul 16 | A | 151 | $82.62 | $12,476 | 3,390 | No | Form 4 |
| Harrington Robert Arthur | Jul 15 | Jul 16 | A | 151 | $82.62 | $12,476 | 21,932 | No | Form 4 |
| Henderson John T | Jul 15 | Jul 16 | A | 272 | $82.62 | $22,473 | 78,360 | No | Form 4 |
| Kaye Edward M. MD | Jul 15 | Jul 16 | A | 151 | $82.62 | $12,476 | 10,434 | No | Form 4 |
| Wierenga Wendell | Jul 15 | Jul 16 | A | 75 | $82.62 | $6,197 | 35,563 | No | Form 4 |
| Wysenski Nancy | Jul 15 | Jul 16 | A | 75 | $82.62 | $6,197 | 33,992 | No | Form 4 |
| Blum Robert IPresident & CEO | Jul 13 | Jul 14 | S | 10 | $82.02 | Sale −$820 | 377,820 | Yes | Form 4 |
| Blum Robert IPresident & CEO | Jul 13 | Jul 14 | M | 7,490 | $10.60 | $79,394 | 385,310 | Yes | Form 4 |
| Blum Robert IPresident & CEO | Jul 13 | Jul 14 | S | 7,490 | $82.02 | Sale −$614,330 | 377,820 | Yes | Form 4 |
| Blum Robert IPresident & CEO | Jul 13 | Jul 14 | M · derivative | 7,490 | $10.60 | $79,394 | 186,745 | Yes | Form 4 |
| Malik Fady IbrahamEVP Research & Development | Jul 7 | Jul 7 | M | 3,500 | $7.80 | $27,300 | 157,402 | Yes | Form 4 |
| Malik Fady IbrahamEVP Research & Development | Jul 7 | Jul 7 | S | 3,500 | $86.62 | Sale −$303,170 | 153,902 | Yes | Form 4 |
| Malik Fady IbrahamEVP Research & Development | Jul 7 | Jul 7 | M · derivative | 3,500 | $7.80 | $27,300 | 37,386 | Yes | Form 4 |
| Lee SungEVP, Chief Financial Officer | Jul 1 | Jul 2 | M | 1,112 | $48.51 | $53,943 | 64,333 | Yes | Form 4 |
| Lee SungEVP, Chief Financial Officer | Jul 1 | Jul 2 | S | 1,112 | $87.79 | Sale −$97,622 | 63,221 | Yes | Form 4 |
| Lee SungEVP, Chief Financial Officer | Jul 1 | Jul 2 | M · derivative | 1,112 | $48.51 | $53,943 | 26,709 | Yes | Form 4 |
| Callos AndrewEVP, Chief Commercial Officer | Jul 1 | Jul 2 | M | 15,000 | $23.26 | $348,900 | 73,555 | Yes | Form 4 |
| Callos AndrewEVP, Chief Commercial Officer | Jul 1 | Jul 2 | S | 15,000 | $85.80 | Sale −$1,287,000 | 58,555 | Yes | Form 4 |
| Callos AndrewEVP, Chief Commercial Officer | Jul 1 | Jul 2 | M · derivative | 15,000 | $23.26 | $348,900 | 24,000 | Yes | Form 4 |
| Blum Robert IPresident & CEO | Jul 1 | Jul 2 | S | 7,500 | $84.92 | Sale −$636,900 | 377,830 | Yes | Form 4 |
| Lee SungEVP, Chief Financial Officer | Jun 29 | Jun 29 | M | 188 | $44.36 | $8,340 | 63,409 | Yes | Form 4 |
| Lee SungEVP, Chief Financial Officer | Jun 29 | Jun 29 | M | 822 | $44.36 | $36,464 | 64,231 | Yes | Form 4 |
| Lee SungEVP, Chief Financial Officer | Jun 29 | Jun 29 | M | 1,113 | $48.51 | $53,992 | 65,344 | Yes | Form 4 |
| Lee SungEVP, Chief Financial Officer | Jun 29 | Jun 29 | M | 188 | $44.36 | $8,340 | 65,532 | Yes | Form 4 |
| Lee SungEVP, Chief Financial Officer | Jun 29 | Jun 29 | M | 823 | $44.36 | $36,508 | 66,355 | Yes | Form 4 |
| Lee SungEVP, Chief Financial Officer | Jun 29 | Jun 29 | S | 3,134 | $85.00 | Sale −$266,390 | 63,221 | Yes | Form 4 |
| Lee SungEVP, Chief Financial Officer | Jun 29 | Jun 29 | M · derivative | 188 | $44.36 | $8,340 | 8,828 | Yes | Form 4 |
| Lee SungEVP, Chief Financial Officer | Jun 29 | Jun 29 | M · derivative | 822 | $44.36 | $36,464 | 40,504 | Yes | Form 4 |
| Lee SungEVP, Chief Financial Officer | Jun 29 | Jun 29 | M · derivative | 1,113 | $48.51 | $53,992 | 52,304 | Yes | Form 4 |
| Lee SungEVP, Chief Financial Officer | Jun 29 | Jun 29 | M · derivative | 188 | $44.36 | $8,340 | 8,640 | Yes | Form 4 |
| Lee SungEVP, Chief Financial Officer | Jun 29 | Jun 29 | M · derivative | 823 | $44.36 | $36,508 | 39,681 | Yes | Form 4 |
| Lee SungEVP, Chief Financial Officer | Jun 24 | Jun 29 | M | 23,370 | $48.51 | $1,133,679 | 86,591 | Yes | Form 4 |
| Lee SungEVP, Chief Financial Officer | Jun 24 | Jun 29 | M | 9,307 | $44.36 | $412,859 | 95,898 | Yes | Form 4 |
| Lee SungEVP, Chief Financial Officer | Jun 24 | Jun 29 | M | 2,817 | $44.36 | $124,962 | 98,715 | Yes | Form 4 |
| Lee SungEVP, Chief Financial Officer | Jun 24 | Jun 29 | M | 1,113 | $48.51 | $53,992 | 99,828 | Yes | Form 4 |
| Lee SungEVP, Chief Financial Officer | Jun 24 | Jun 29 | M | 188 | $44.36 | $8,340 | 100,016 | Yes | Form 4 |
| Lee SungEVP, Chief Financial Officer | Jun 24 | Jun 29 | M | 822 | $44.36 | $36,464 | 100,838 | Yes | Form 4 |
| Lee SungEVP, Chief Financial Officer | Jun 24 | Jun 29 | M | 1,113 | $48.51 | $53,992 | 101,951 | Yes | Form 4 |
| Lee SungEVP, Chief Financial Officer | Jun 24 | Jun 29 | S | 38,730 | $82.30 | Sale −$3,187,479 | 63,221 | Yes | Form 4 |
| Lee SungEVP, Chief Financial Officer | Jun 24 | Jun 29 | M · derivative | 23,370 | $48.51 | $1,133,679 | 30,047 | Yes | Form 4 |
| Lee SungEVP, Chief Financial Officer | Jun 24 | Jun 29 | M · derivative | 9,307 | $44.36 | $412,859 | 32,019 | Yes | Form 4 |
| Lee SungEVP, Chief Financial Officer | Jun 24 | Jun 29 | M · derivative | 2,817 | $44.36 | $124,962 | 6,199 | Yes | Form 4 |
| Lee SungEVP, Chief Financial Officer | Jun 24 | Jun 29 | M · derivative | 1,113 | $48.51 | $53,992 | 28,934 | Yes | Form 4 |
| Lee SungEVP, Chief Financial Officer | Jun 24 | Jun 29 | M · derivative | 188 | $44.36 | $8,340 | 6,011 | Yes | Form 4 |
| Lee SungEVP, Chief Financial Officer | Jun 24 | Jun 29 | M · derivative | 822 | $44.36 | $36,464 | 31,197 | Yes | Form 4 |
| Lee SungEVP, Chief Financial Officer | Jun 24 | Jun 29 | M · derivative | 1,113 | $48.51 | $53,992 | 27,821 | Yes | Form 4 |
| Malik Fady IbrahamEVP Research & Development | Jun 23 | Jun 23 | M | 3,500 | $7.80 | $27,300 | 157,402 | Yes | Form 4 |
| Malik Fady IbrahamEVP Research & Development | Jun 23 | Jun 23 | S | 3,500 | $79.51 | Sale −$278,285 | 153,902 | Yes | Form 4 |
| Malik Fady IbrahamEVP Research & Development | Jun 23 | Jun 23 | M · derivative | 3,500 | $7.80 | $27,300 | 40,886 | Yes | Form 4 |
| Blum Robert IPresident & CEO | Jun 15 | Jun 15 | S | 7,500 | $70.46 | Sale −$528,450 | 385,330 | Yes | Form 4 |
| Malik Fady IbrahamEVP Research & Development | Jun 9 | Jun 9 | M | 3,500 | $7.80 | $27,300 | 157,402 | Yes | Form 4 |
| Malik Fady IbrahamEVP Research & Development | Jun 9 | Jun 9 | S | 3,500 | $67.98 | Sale −$237,930 | 153,902 | Yes | Form 4 |
| Malik Fady IbrahamEVP Research & Development | Jun 9 | Jun 9 | M · derivative | 3,500 | $7.80 | $27,300 | 44,386 | Yes | Form 4 |
| Parshall B Lynne | Jun 1 | Jun 1 | S | 5,000 | $74.08 | Sale −$370,400 | 15,784 | Yes | Form 4 |
| Callos AndrewEVP, Chief Commercial Officer | Jun 1 | Jun 1 | M | 15,000 | $23.26 | $348,900 | 73,555 | Yes | Form 4 |
| Callos AndrewEVP, Chief Commercial Officer | Jun 1 | Jun 1 | S | 15,000 | $74.08 | Sale −$1,111,200 | 58,555 | Yes | Form 4 |
| Callos AndrewEVP, Chief Commercial Officer | Jun 1 | Jun 1 | M · derivative | 15,000 | $23.26 | $348,900 | 39,000 | Yes | Form 4 |
| Kaye Edward M. MD | Jun 1 | Jun 1 | S | 2,933 | $76.09 | Sale −$223,172 | 10,283 | Yes | Form 4 |
| Blum Robert IPresident & CEO | May 27 | May 28 | S | 7,500 | $77.21 | Sale −$579,075 | 392,830 | Yes | Form 4 |
| Wysenski Nancy | May 27 | May 27 | A | 2,851 | $0.00 | $0 | 33,917 | No | Form 4 |
| Wysenski Nancy | May 27 | May 27 | A · derivative | 4,301 | $77.15 | $331,822 | 4,301 | No | Form 4 |
| Wierenga Wendell | May 27 | May 27 | A | 2,851 | $0.00 | $0 | 35,488 | No | Form 4 |
| Wierenga Wendell | May 27 | May 27 | A · derivative | 4,301 | $77.15 | $331,822 | 4,301 | No | Form 4 |
| Landry Robert E | May 27 | May 27 | A | 2,851 | $0.00 | $0 | 10,184 | No | Form 4 |
| Landry Robert E | May 27 | May 27 | A · derivative | 4,301 | $77.15 | $331,822 | 4,301 | No | Form 4 |
| Parshall B Lynne | May 27 | May 27 | A | 2,851 | $0.00 | $0 | 20,784 | No | Form 4 |
| Parshall B Lynne | May 27 | May 27 | A · derivative | 4,301 | $77.15 | $331,822 | 4,301 | No | Form 4 |
| Kaye Edward M. MD | May 27 | May 27 | A | 2,851 | $0.00 | $0 | 13,216 | No | Form 4 |
| Kaye Edward M. MD | May 27 | May 27 | A · derivative | 4,301 | $77.15 | $331,822 | 4,301 | No | Form 4 |
| Henderson John T | May 27 | May 27 | A | 2,851 | $0.00 | $0 | 78,088 | No | Form 4 |
| Henderson John T | May 27 | May 27 | A · derivative | 4,301 | $77.15 | $331,822 | 4,301 | No | Form 4 |
| Harrington Robert Arthur | May 27 | May 27 | A | 2,851 | $0.00 | $0 | 21,781 | No | Form 4 |
| Harrington Robert Arthur | May 27 | May 27 | A · derivative | 4,301 | $77.15 | $331,822 | 4,301 | No | Form 4 |
| Daly James M | May 27 | May 27 | A | 2,851 | $0.00 | $0 | 3,239 | No | Form 4 |
| Daly James M | May 27 | May 27 | A · derivative | 4,301 | $77.15 | $331,822 | 4,301 | No | Form 4 |
| Bhanji Muna | May 27 | May 27 | A | 2,851 | $0.00 | $0 | 26,361 | No | Form 4 |
| Bhanji Muna | May 27 | May 27 | A · derivative | 4,301 | $77.15 | $331,822 | 4,301 | No | Form 4 |
| Malik Fady IbrahamEVP Research & Development | May 19 | May 20 | M | 3,500 | $7.80 | $27,300 | 157,402 | Yes | Form 4 |
| Malik Fady IbrahamEVP Research & Development | May 19 | May 20 | S | 3,500 | $75.69 | Sale −$264,915 | 153,902 | Yes | Form 4 |
| Malik Fady IbrahamEVP Research & Development | May 19 | May 20 | M · derivative | 3,500 | $7.80 | $27,300 | 47,886 | Yes | Form 4 |
| Blum Robert IPresident & CEO | May 14 | May 14 | S | 7,500 | $77.92 | Sale −$584,400 | 400,330 | Yes | Form 4 |
| Callos AndrewEVP, Chief Commercial Officer | May 5 | May 5 | M | 11,333 | $39.13 | $443,460 | 69,888 | Yes | Form 4 |
| Callos AndrewEVP, Chief Commercial Officer | May 5 | May 5 | S | 11,333 | $77.25 | Sale −$875,474 | 58,555 | Yes | Form 4 |
| Callos AndrewEVP, Chief Commercial Officer | May 5 | May 5 | M · derivative | 11,333 | $39.13 | $443,460 | 13,070 | Yes | Form 4 |
| Henderson John T | May 5 | May 5 | M | 20,000 | $7.61 | $152,200 | 95,237 | Yes | Form 4 |
| Henderson John T | May 5 | May 5 | S | 20,000 | $75.97 | Sale −$1,519,400 | 75,237 | Yes | Form 4 |
| Henderson John T | May 5 | May 5 | M · derivative | 20,000 | $7.61 | $152,200 | not reported | Yes | Form 4 |
| Lee SungEVP, Chief Financial Officer | May 5 | May 5 | S | 23,906 | $76.87 | Sale −$1,837,654 | 63,221 | Yes | Form 4 |
| Wierenga Wendell | May 5 | May 5 | M | 4,032 | $12.40 | $49,997 | 36,669 | Yes | Form 4 |
| Wierenga Wendell | May 5 | May 5 | S | 4,032 | $75.00 | Sale −$302,400 | 32,637 | Yes | Form 4 |
| Wierenga Wendell | May 5 | May 5 | M · derivative | 4,032 | $12.40 | $49,997 | not reported | Yes | Form 4 |
| Malik Fady IbrahamEVP Research & Development | May 5 | May 5 | M | 3,500 | $7.80 | $27,300 | 157,402 | Yes | Form 4 |
| Malik Fady IbrahamEVP Research & Development | May 5 | May 5 | S | 3,500 | $77.37 | Sale −$270,795 | 153,902 | Yes | Form 4 |
| Malik Fady IbrahamEVP Research & Development | May 5 | May 5 | M · derivative | 3,500 | $7.80 | $27,300 | 51,386 | Yes | Form 4 |
| Callos AndrewEVP, Chief Commercial Officer | May 1 | May 4 | M | 15,857 | $37.63 | $596,699 | 74,412 | Yes | Form 4 |
| Callos AndrewEVP, Chief Commercial Officer | May 1 | May 4 | S | 15,857 | $65.00 | Sale −$1,030,705 | 58,555 | Yes | Form 4 |
| Callos AndrewEVP, Chief Commercial Officer | May 1 | May 4 | M · derivative | 15,857 | $37.63 | $596,699 | not reported | Yes | Form 4 |
| Callos AndrewEVP, Chief Commercial Officer | Apr 30 | Apr 30 | M | 15,000 | $23.26 | $348,900 | 73,555 | Yes | Form 4 |
| Callos AndrewEVP, Chief Commercial Officer | Apr 30 | Apr 30 | S | 15,000 | $63.26 | Sale −$948,900 | 58,555 | Yes | Form 4 |
| Callos AndrewEVP, Chief Commercial Officer | Apr 30 | Apr 30 | M · derivative | 15,000 | $23.26 | $348,900 | 54,000 | Yes | Form 4 |
| Blum Robert IPresident & CEO | Apr 29 | Apr 29 | S | 7,500 | $59.62 | Sale −$447,150 | 407,830 | Yes | Form 4 |
| Malik Fady IbrahamEVP Research & Development | Apr 21 | Apr 21 | M | 3,500 | $7.80 | $27,300 | 157,402 | Yes | Form 4 |
| Malik Fady IbrahamEVP Research & Development | Apr 21 | Apr 21 | S | 3,500 | $65.69 | Sale −$229,915 | 153,902 | Yes | Form 4 |
| Malik Fady IbrahamEVP Research & Development | Apr 21 | Apr 21 | M · derivative | 3,500 | $7.80 | $27,300 | 54,886 | Yes | Form 4 |
| Blum Robert IPresident & CEO | Apr 15 | Apr 15 | S | 7,500 | $65.38 | Sale −$490,350 | 415,330 | Yes | Form 4 |
| Callos AndrewEVP, Chief Commercial Officer | Apr 15 | Apr 15 | S | 7,449 | $66.02 | Sale −$491,783 | 58,555 | Yes | Form 4 |
| Daly James M | Apr 15 | Apr 15 | A | 191 | $65.37 | $12,486 | 388 | No | Form 4 |
| Harrington Robert Arthur | Apr 15 | Apr 15 | A | 191 | $65.37 | $12,486 | 18,930 | No | Form 4 |
| Henderson John T | Apr 15 | Apr 15 | A | 325 | $65.37 | $21,245 | 75,237 | No | Form 4 |
| Kaye Edward M. MD | Apr 15 | Apr 15 | A | 191 | $65.37 | $12,486 | 10,365 | No | Form 4 |
| Wierenga Wendell | Apr 15 | Apr 15 | A | 95 | $65.37 | $6,210 | 32,637 | No | Form 4 |
| Wysenski Nancy | Apr 15 | Apr 15 | A | 95 | $65.37 | $6,210 | 31,066 | No | Form 4 |
| Malik Fady IbrahamEVP Research & Development | Apr 7 | Apr 8 | M | 3,500 | $7.80 | $27,300 | 157,402 | Yes | Form 4 |
| Malik Fady IbrahamEVP Research & Development | Apr 7 | Apr 8 | S | 3,500 | $65.21 | Sale −$228,235 | 153,902 | Yes | Form 4 |
| Malik Fady IbrahamEVP Research & Development | Apr 7 | Apr 8 | M | 1,000 | $10.60 | $10,600 | 154,902 | Yes | Form 4 |
| Malik Fady IbrahamEVP Research & Development | Apr 7 | Apr 8 | S | 1,000 | $64.75 | Sale −$64,750 | 153,902 | Yes | Form 4 |
| Malik Fady IbrahamEVP Research & Development | Apr 7 | Apr 8 | M · derivative | 3,500 | $7.80 | $27,300 | 58,386 | Yes | Form 4 |
| Malik Fady IbrahamEVP Research & Development | Apr 7 | Apr 8 | M · derivative | 1,000 | $10.60 | $10,600 | not reported | Yes | Form 4 |
| Blum Robert IPresident & CEO | Apr 1 | Apr 1 | S | 7,500 | $66.63 | Sale −$499,725 | 422,830 | Yes | Form 4 |
| Callos AndrewEVP, Chief Commercial Officer | Mar 31 | Mar 31 | S | 3,639 | $65.00 | Sale −$236,535 | 66,004 | Yes | Form 4 |
| Callos AndrewEVP, Chief Commercial Officer | Mar 18 | Mar 18 | S | 1,930 | $62.07 | Sale −$119,795 | 78,185 | Yes | Form 4 |
| Blum Robert IPresident & CEO | Mar 17 | Mar 18 | S | 12,673 | $62.15 | Sale −$787,627 | 454,258 | No | Form 4 |
| Blum Robert IPresident & CEO | Mar 17 | Mar 18 | S | 23,928 | $62.15 | Sale −$1,487,125 | 430,330 | No | Form 4 |
| Malik Fady IbrahamEVP Research & Development | Mar 17 | Mar 18 | S | 7,636 | $62.15 | Sale −$474,577 | 158,299 | No | Form 4 |
| Malik Fady IbrahamEVP Research & Development | Mar 17 | Mar 18 | S | 4,397 | $62.15 | Sale −$273,274 | 153,902 | No | Form 4 |
| Callos AndrewEVP, Chief Commercial Officer | Mar 17 | Mar 18 | S | 5,626 | $62.15 | Sale −$349,656 | 74,489 | No | Form 4 |
| Callos AndrewEVP, Chief Commercial Officer | Mar 17 | Mar 18 | S | 2,916 | $62.15 | Sale −$181,229 | 71,573 | No | Form 4 |
| Lee SungEVP, Chief Financial Officer | Mar 17 | Mar 18 | S | 4,935 | $62.15 | Sale −$306,710 | 87,127 | No | Form 4 |
| Malik Fady IbrahamEVP Research & Development | Mar 15 | Mar 17 | A | 27,306 | $0.00 | $0 | 165,935 | No | Form 4 |
| Malik Fady IbrahamEVP Research & Development | Mar 15 | Mar 17 | A · derivative | 1,665 | $60.06 | $100,000 | 1,665 | No | Form 4 |
| Malik Fady IbrahamEVP Research & Development | Mar 15 | Mar 17 | A · derivative | 39,527 | $60.06 | $2,373,992 | 39,527 | No | Form 4 |
| Lee SungEVP, Chief Financial Officer | Mar 15 | Mar 17 | A | 20,646 | $0.00 | $0 | 92,062 | No | Form 4 |
| Lee SungEVP, Chief Financial Officer | Mar 15 | Mar 17 | A · derivative | 1,665 | $60.06 | $100,000 | 1,665 | No | Form 4 |
| Lee SungEVP, Chief Financial Officer | Mar 15 | Mar 17 | A · derivative | 29,480 | $60.06 | $1,770,569 | 29,480 | No | Form 4 |
| Hessekiel JeffreyChief Legal & Admin Officer | Mar 15 | Mar 17 | A | 20,646 | $0.00 | $0 | 107,943 | No | Form 4 |
| Hessekiel JeffreyChief Legal & Admin Officer | Mar 15 | Mar 17 | A · derivative | 8,325 | $60.06 | $500,000 | 8,325 | No | Form 4 |
| Hessekiel JeffreyChief Legal & Admin Officer | Mar 15 | Mar 17 | A · derivative | 22,820 | $60.06 | $1,370,569 | 22,820 | No | Form 4 |
| Callos AndrewEVP, Chief Commercial Officer | Mar 15 | Mar 17 | A | 20,646 | $0.00 | $0 | 68,504 | No | Form 4 |
| Callos AndrewEVP, Chief Commercial Officer | Mar 15 | Mar 17 | A | 13,320 | $0.00 | $0 | 81,824 | No | Form 4 |
| Callos AndrewEVP, Chief Commercial Officer | Mar 15 | Mar 17 | A · derivative | 1,665 | $60.06 | $100,000 | 1,665 | No | Form 4 |
| Callos AndrewEVP, Chief Commercial Officer | Mar 15 | Mar 17 | A · derivative | 29,480 | $60.06 | $1,770,569 | 29,480 | No | Form 4 |
| Blum Robert IPresident & CEO | Mar 15 | Mar 17 | A | 75,258 | $0.00 | $0 | 466,931 | No | Form 4 |
| Blum Robert IPresident & CEO | Mar 15 | Mar 17 | A · derivative | 1,665 | $60.06 | $100,000 | 1,665 | No | Form 4 |
| Blum Robert IPresident & CEO | Mar 15 | Mar 17 | A · derivative | 111,864 | $60.06 | $6,718,552 | 111,864 | No | Form 4 |
| Callos AndrewEVP, Chief Commercial Officer | Mar 16 | Mar 16 | S | 1,709 | $61.03 | Sale −$104,300 | 46,149 | Yes | Form 4 |
| Blum Robert IPresident & CEO | Mar 9 | Mar 10 | S | 7,931 | $60.72 | Sale −$481,570 | 391,673 | No | Form 4 |
| Malik Fady IbrahamEVP Research & Development | Mar 9 | Mar 10 | S | 2,907 | $60.72 | Sale −$176,513 | 138,629 | No | Form 4 |
| Callos AndrewEVP, Chief Commercial Officer | Mar 9 | Mar 10 | S | 2,582 | $60.72 | Sale −$156,779 | 47,858 | No | Form 4 |
| Callos AndrewEVP, Chief Commercial Officer | Mar 5 | Mar 5 | M | 11,000 | $39.13 | $430,430 | 76,440 | Yes | Form 4 |
| Callos AndrewEVP, Chief Commercial Officer | Mar 5 | Mar 5 | S | 15,000 | $61.87 | Sale −$928,050 | 61,440 | Yes | Form 4 |
| Callos AndrewEVP, Chief Commercial Officer | Mar 5 | Mar 5 | S | 11,000 | $61.88 | Sale −$680,680 | 50,440 | Yes | Form 4 |
| Callos AndrewEVP, Chief Commercial Officer | Mar 5 | Mar 5 | M | 15,000 | $23.26 | $348,900 | 65,440 | Yes | Form 4 |
| Callos AndrewEVP, Chief Commercial Officer | Mar 5 | Mar 5 | M · derivative | 11,000 | $39.13 | $430,430 | 24,403 | Yes | Form 4 |
| Callos AndrewEVP, Chief Commercial Officer | Mar 5 | Mar 5 | M · derivative | 15,000 | $23.26 | $348,900 | 69,000 | Yes | Form 4 |
| Callos AndrewEVP, Chief Commercial Officer | Mar 2 | Mar 2 | M | 886 | $37.63 | $33,340 | 51,326 | Yes | Form 4 |
| Callos AndrewEVP, Chief Commercial Officer | Mar 2 | Mar 2 | S | 886 | $61.62 | Sale −$54,595 | 50,440 | Yes | Form 4 |
| Callos AndrewEVP, Chief Commercial Officer | Mar 2 | Mar 2 | M · derivative | 886 | $37.63 | $33,340 | not reported | Yes | Form 4 |
| Parshall B Lynne | Mar 2 | Mar 2 | S | 5,000 | $61.21 | Sale −$306,050 | 17,933 | Yes | Form 4 |
| Callos AndrewEVP, Chief Commercial Officer | Feb 5 | Feb 5 | M | 15,000 | $23.26 | $348,900 | 65,440 | Yes | Form 4 |
| Callos AndrewEVP, Chief Commercial Officer | Feb 5 | Feb 5 | S | 15,000 | $61.93 | Sale −$928,950 | 50,440 | Yes | Form 4 |
| Callos AndrewEVP, Chief Commercial Officer | Feb 5 | Feb 5 | M · derivative | 15,000 | $23.26 | $348,900 | 84,000 | Yes | Form 4 |
| Callos AndrewEVP, Chief Commercial Officer | Feb 2 | Feb 2 | M | 886 | $37.63 | $33,340 | 51,326 | Yes | Form 4 |
| Callos AndrewEVP, Chief Commercial Officer | Feb 2 | Feb 2 | S | 886 | $62.10 | Sale −$55,021 | 50,440 | Yes | Form 4 |
| Callos AndrewEVP, Chief Commercial Officer | Feb 2 | Feb 2 | M · derivative | 886 | $37.63 | $33,340 | 886 | Yes | Form 4 |
| Daly James M | Jan 15 | Jan 20 | A | 197 | $63.44 | $12,498 | 197 | No | Form 4 |
| Harrington Robert Arthur | Jan 15 | Jan 16 | A | 197 | $63.44 | $12,498 | 18,739 | No | Form 4 |
| Henderson John T | Jan 15 | Jan 16 | A | 334 | $63.44 | $21,189 | 74,912 | No | Form 4 |
| Kaye Edward M. MD | Jan 15 | Jan 16 | A | 197 | $63.44 | $12,498 | 10,174 | No | Form 4 |
| Wierenga Wendell | Jan 15 | Jan 16 | A | 98 | $63.44 | $6,217 | 32,542 | No | Form 4 |
| Wysenski Nancy | Jan 15 | Jan 16 | A | 98 | $63.44 | $6,217 | 30,971 | No | Form 4 |
| Callos AndrewEVP, Chief Commercial Officer | Jan 5 | Jan 5 | M | 15,000 | $23.26 | $348,900 | 65,440 | Yes | Form 4 |
| Callos AndrewEVP, Chief Commercial Officer | Jan 5 | Jan 5 | S | 15,000 | $60.28 | Sale −$904,200 | 50,440 | Yes | Form 4 |
| Callos AndrewEVP, Chief Commercial Officer | Jan 5 | Jan 5 | M · derivative | 15,000 | $23.26 | $348,900 | 99,000 | Yes | Form 4 |
| Callos AndrewEVP, Chief Commercial Officer | Jan 2 | Jan 2 | S | 913 | $62.09 | Sale −$56,688 | 50,440 | Yes | Form 4 |
| Callos AndrewEVP, Chief Commercial Officer | Jan 2 | Jan 2 | M | 885 | $37.63 | $33,303 | 51,325 | Yes | Form 4 |
| Callos AndrewEVP, Chief Commercial Officer | Jan 2 | Jan 2 | S | 885 | $63.16 | Sale −$55,897 | 50,440 | Yes | Form 4 |
| Callos AndrewEVP, Chief Commercial Officer | Jan 2 | Jan 2 | M · derivative | 885 | $37.63 | $33,303 | 1,772 | Yes | Form 4 |
| Callos AndrewEVP, Chief Commercial Officer | Dec 29, 2025 | Dec 30, 2025 | S | 1,809 | $62.44 | Sale −$112,954 | 51,353 | Yes | Form 4 |
| Lee SungEVP, Chief Financial Officer | Dec 22, 2025 | Dec 29, 2025 | A | 2,152 | $0.00 | $0 | 70,069 | No | Form 4 |
| Lee SungEVP, Chief Financial Officer | Dec 22, 2025 | Dec 29, 2025 | A | 2,152 | $0.00 | $0 | 72,221 | No | Form 4 |
| Lee SungEVP, Chief Financial Officer | Dec 22, 2025 | Dec 29, 2025 | F | 805 | $62.72 | $50,490 | 71,416 | No | Form 4 |
| Callos AndrewEVP, Chief Commercial Officer | Dec 22, 2025 | Dec 29, 2025 | A | 1,589 | $0.00 | $0 | 52,249 | No | Form 4 |
| Callos AndrewEVP, Chief Commercial Officer | Dec 22, 2025 | Dec 29, 2025 | A | 1,588 | $0.00 | $0 | 53,837 | No | Form 4 |
| Callos AndrewEVP, Chief Commercial Officer | Dec 22, 2025 | Dec 29, 2025 | F | 675 | $62.72 | $42,336 | 53,162 | No | Form 4 |
| Malik Fady IbrahamEVP Research & Development | Dec 22, 2025 | Dec 29, 2025 | A | 2,000 | $0.00 | $0 | 140,552 | No | Form 4 |
| Malik Fady IbrahamEVP Research & Development | Dec 22, 2025 | Dec 29, 2025 | A | 2,000 | $0.00 | $0 | 142,552 | No | Form 4 |
| Malik Fady IbrahamEVP Research & Development | Dec 22, 2025 | Dec 29, 2025 | F | 1,016 | $62.72 | $63,724 | 141,536 | No | Form 4 |
| Blum Robert IPresident & CEO | Dec 22, 2025 | Dec 29, 2025 | A | 5,765 | $0.00 | $0 | 396,774 | No | Form 4 |
| Blum Robert IPresident & CEO | Dec 22, 2025 | Dec 29, 2025 | A | 5,765 | $0.00 | $0 | 402,539 | No | Form 4 |
| Blum Robert IPresident & CEO | Dec 22, 2025 | Dec 29, 2025 | F | 2,935 | $62.72 | $184,083 | 399,604 | No | Form 4 |
| Wierenga Wendell | Dec 22, 2025 | Dec 23, 2025 | M | 20,000 | $7.61 | $152,200 | 52,444 | Yes | Form 4 |
| Wierenga Wendell | Dec 22, 2025 | Dec 23, 2025 | S | 20,000 | $66.14 | Sale −$1,322,800 | 32,444 | Yes | Form 4 |
| Wierenga Wendell | Dec 22, 2025 | Dec 23, 2025 | M · derivative | 20,000 | $7.61 | $152,200 | not reported | Yes | Form 4 |
| Blum Robert IPresident & CEO | Dec 22, 2025 | Dec 23, 2025 | M | 54,727 | $6.67 | $365,029 | 404,929 | No | Form 4 |
| Blum Robert IPresident & CEO | Dec 22, 2025 | Dec 23, 2025 | F | 30,426 | $68.18 | $2,074,445 | 374,503 | No | Form 4 |
| Blum Robert IPresident & CEO | Dec 22, 2025 | Dec 23, 2025 | M | 16,506 | $6.67 | $110,095 | 391,009 | No | Form 4 |
| Blum Robert IPresident & CEO | Dec 22, 2025 | Dec 23, 2025 | M · derivative | 54,727 | $6.67 | $365,029 | not reported | No | Form 4 |
| Blum Robert IPresident & CEO | Dec 22, 2025 | Dec 23, 2025 | M · derivative | 16,506 | $6.67 | $110,095 | not reported | No | Form 4 |
| Malik Fady IbrahamEVP Research & Development | Dec 16, 2025 | Dec 16, 2025 | M | 2,200 | $10.60 | $23,320 | 140,752 | Yes | Form 4 |
| Malik Fady IbrahamEVP Research & Development | Dec 16, 2025 | Dec 16, 2025 | S | 2,200 | $61.24 | Sale −$134,728 | 138,552 | Yes | Form 4 |
| Malik Fady IbrahamEVP Research & Development | Dec 16, 2025 | Dec 16, 2025 | M · derivative | 2,200 | $10.60 | $23,320 | not reported | Yes | Form 4 |
| Callos AndrewEVP, Chief Commercial Officer | Dec 8, 2025 | Dec 8, 2025 | M | 1,042 | $39.13 | $40,773 | 51,702 | Yes | Form 4 |
| Callos AndrewEVP, Chief Commercial Officer | Dec 8, 2025 | Dec 8, 2025 | S | 1,042 | $65.96 | Sale −$68,730 | 50,660 | Yes | Form 4 |
| Callos AndrewEVP, Chief Commercial Officer | Dec 8, 2025 | Dec 8, 2025 | M · derivative | 1,042 | $39.13 | $40,773 | 35,403 | Yes | Form 4 |
| Callos AndrewEVP, Chief Commercial Officer | Dec 5, 2025 | Dec 5, 2025 | M | 15,000 | $23.26 | $348,900 | 65,660 | Yes | Form 4 |
| Callos AndrewEVP, Chief Commercial Officer | Dec 5, 2025 | Dec 5, 2025 | M | 11,000 | $39.13 | $430,430 | 76,660 | Yes | Form 4 |
| Callos AndrewEVP, Chief Commercial Officer | Dec 5, 2025 | Dec 5, 2025 | M | 15,858 | $37.63 | $596,737 | 92,518 | Yes | Form 4 |
| Callos AndrewEVP, Chief Commercial Officer | Dec 5, 2025 | Dec 5, 2025 | M | 10,628 | $37.63 | $399,932 | 103,146 | Yes | Form 4 |
| Callos AndrewEVP, Chief Commercial Officer | Dec 5, 2025 | Dec 5, 2025 | S | 52,486 | $65.95 | Sale −$3,461,452 | 50,660 | Yes | Form 4 |
| Callos AndrewEVP, Chief Commercial Officer | Dec 5, 2025 | Dec 5, 2025 | M · derivative | 15,000 | $23.26 | $348,900 | 114,000 | Yes | Form 4 |
| Callos AndrewEVP, Chief Commercial Officer | Dec 5, 2025 | Dec 5, 2025 | M · derivative | 11,000 | $39.13 | $430,430 | 36,445 | Yes | Form 4 |
| Callos AndrewEVP, Chief Commercial Officer | Dec 5, 2025 | Dec 5, 2025 | M · derivative | 15,858 | $37.63 | $596,737 | 15,857 | Yes | Form 4 |
| Callos AndrewEVP, Chief Commercial Officer | Dec 5, 2025 | Dec 5, 2025 | M · derivative | 10,628 | $37.63 | $399,932 | 2,657 | Yes | Form 4 |
| Blum Robert IPresident & CEO | Dec 3, 2025 | Dec 5, 2025 | F | 5,930 | $65.02 | $385,569 | 350,202 | No | Form 4 |
| Malik Fady IbrahamEVP Research & Development | Dec 3, 2025 | Dec 5, 2025 | F | 2,058 | $65.02 | $133,811 | 138,552 | No | Form 4 |
| Callos AndrewEVP, Chief Commercial Officer | Dec 3, 2025 | Dec 5, 2025 | F | 1,368 | $65.02 | $88,947 | 50,660 | No | Form 4 |
| Lee SungEVP, Chief Financial Officer | Dec 3, 2025 | Dec 5, 2025 | F | 1,560 | $65.02 | $101,431 | 67,917 | No | Form 4 |
| Malik Fady IbrahamEVP Research & Development | Dec 2, 2025 | Dec 2, 2025 | M | 2,200 | $10.60 | $23,320 | 142,810 | Yes | Form 4 |
| Malik Fady IbrahamEVP Research & Development | Dec 2, 2025 | Dec 2, 2025 | S | 2,200 | $63.89 | Sale −$140,558 | 140,610 | Yes | Form 4 |
| Malik Fady IbrahamEVP Research & Development | Dec 2, 2025 | Dec 2, 2025 | M · derivative | 2,200 | $10.60 | $23,320 | 2,200 | Yes | Form 4 |
| Henderson John T | Dec 2, 2025 | Dec 2, 2025 | M | 8,750 | $10.00 | $87,500 | 83,328 | Yes | Form 4 |
| Henderson John T | Dec 2, 2025 | Dec 2, 2025 | S | 8,750 | $63.90 | Sale −$559,125 | 74,578 | Yes | Form 4 |
| Henderson John T | Dec 2, 2025 | Dec 2, 2025 | M · derivative | 8,750 | $10.00 | $87,500 | not reported | Yes | Form 4 |
| Harrington Robert Arthur | Dec 1, 2025 | Dec 2, 2025 | S | 2,150 | $66.80 | Sale −$143,620 | 18,542 | Yes | Form 4 |
| Kaye Edward M. MD | Dec 1, 2025 | Dec 2, 2025 | M | 8,064 | $12.40 | $99,994 | 18,041 | Yes | Form 4 |
| Kaye Edward M. MD | Dec 1, 2025 | Dec 2, 2025 | M | 20,000 | $14.25 | $285,000 | 38,041 | Yes | Form 4 |
| Kaye Edward M. MD | Dec 1, 2025 | Dec 2, 2025 | S | 28,064 | $66.72 | Sale −$1,872,430 | 9,977 | Yes | Form 4 |
| Kaye Edward M. MD | Dec 1, 2025 | Dec 2, 2025 | M · derivative | 8,064 | $12.40 | $99,994 | not reported | Yes | Form 4 |
| Kaye Edward M. MD | Dec 1, 2025 | Dec 2, 2025 | M · derivative | 20,000 | $14.25 | $285,000 | not reported | Yes | Form 4 |
| Parshall B Lynne | Nov 19, 2025 | Nov 19, 2025 | S | 5,000 | $64.73 | Sale −$323,650 | 22,933 | Yes | Form 4 |
| Malik Fady IbrahamEVP Research & Development | Nov 18, 2025 | Nov 18, 2025 | M | 2,200 | $10.60 | $23,320 | 142,810 | Yes | Form 4 |
| Malik Fady IbrahamEVP Research & Development | Nov 18, 2025 | Nov 18, 2025 | S | 2,200 | $66.45 | Sale −$146,190 | 140,610 | Yes | Form 4 |
| Malik Fady IbrahamEVP Research & Development | Nov 18, 2025 | Nov 18, 2025 | M · derivative | 2,200 | $10.60 | $23,320 | 4,400 | Yes | Form 4 |
| Hessekiel JeffreyChief Legal & Admin Officer | Nov 14, 2025 | Nov 17, 2025 | A | 87,297 | $0.00 | $0 | 87,297 | No | Form 4 |
| Kaye Edward M. MD | Nov 11, 2025 | Nov 12, 2025 | M | 5,175 | $9.66 | $49,991 | 15,152 | Yes | Form 4 |
| Kaye Edward M. MD | Nov 11, 2025 | Nov 12, 2025 | S | 5,175 | $65.08 | Sale −$336,789 | 9,977 | Yes | Form 4 |
| Kaye Edward M. MD | Nov 11, 2025 | Nov 12, 2025 | M · derivative | 5,175 | $9.66 | $49,991 | not reported | Yes | Form 4 |
| Blum Robert IPresident & CEO | Nov 5, 2025 | Nov 5, 2025 | G | 2,000 | $0.00 | $0 | 356,108 | No | Form 4 |
| Malik Fady IbrahamEVP Research & Development | Nov 4, 2025 | Nov 4, 2025 | M | 2,295 | $10.60 | $24,327 | 142,905 | Yes | Form 4 |
| Malik Fady IbrahamEVP Research & Development | Nov 4, 2025 | Nov 4, 2025 | S | 2,295 | $59.55 | Sale −$136,667 | 140,610 | Yes | Form 4 |
| Malik Fady IbrahamEVP Research & Development | Nov 4, 2025 | Nov 4, 2025 | M · derivative | 2,295 | $10.60 | $24,327 | 6,600 | Yes | Form 4 |
| Blum Robert IPresident & CEO | Oct 30, 2025 | Oct 30, 2025 | S | 5,000 | $62.86 | Sale −$314,300 | 358,108 | Yes | Form 4 |
| Wierenga Wendell | Oct 27, 2025 | Oct 27, 2025 | M | 4,375 | $10.00 | $43,750 | 36,819 | Yes | Form 4 |
| Wierenga Wendell | Oct 27, 2025 | Oct 27, 2025 | S | 4,375 | $58.68 | Sale −$256,725 | 32,444 | Yes | Form 4 |
| Wierenga Wendell | Oct 27, 2025 | Oct 27, 2025 | M · derivative | 4,375 | $10.00 | $43,750 | not reported | Yes | Form 4 |
| Malik Fady IbrahamEVP Research & Development | Oct 21, 2025 | Oct 21, 2025 | M | 2,105 | $10.60 | $22,313 | 142,715 | Yes | Form 4 |
| Malik Fady IbrahamEVP Research & Development | Oct 21, 2025 | Oct 21, 2025 | S | 2,105 | $58.22 | Sale −$122,553 | 140,610 | Yes | Form 4 |
| Malik Fady IbrahamEVP Research & Development | Oct 21, 2025 | Oct 21, 2025 | M · derivative | 2,105 | $10.60 | $22,313 | 1,000 | Yes | Form 4 |
| Wierenga Wendell | Oct 15, 2025 | Oct 21, 2025 | A | 99 | $62.80 | $6,217 | 32,444 | No | Form 4 |
| Blum Robert IPresident & CEO | Oct 16, 2025 | Oct 16, 2025 | S | 5,000 | $60.03 | Sale −$300,150 | 363,108 | Yes | Form 4 |
| Wysenski Nancy | Oct 15, 2025 | Oct 16, 2025 | A | 99 | $62.80 | $6,217 | 30,873 | No | Form 4 |
| Kaye Edward M. MD | Oct 15, 2025 | Oct 16, 2025 | A | 199 | $62.80 | $12,497 | 9,977 | No | Form 4 |
| Henderson John T | Oct 15, 2025 | Oct 16, 2025 | A | 338 | $62.80 | $21,226 | 74,578 | No | Form 4 |
| Harrington Robert Arthur | Oct 15, 2025 | Oct 16, 2025 | A | 199 | $62.80 | $12,497 | 20,692 | No | Form 4 |
| Malik Fady IbrahamEVP Research & Development | Oct 7, 2025 | Oct 7, 2025 | M | 2,000 | $10.60 | $21,200 | 142,610 | Yes | Form 4 |
| Malik Fady IbrahamEVP Research & Development | Oct 7, 2025 | Oct 7, 2025 | S | 2,000 | $60.56 | Sale −$121,120 | 140,610 | Yes | Form 4 |
| Malik Fady IbrahamEVP Research & Development | Oct 7, 2025 | Oct 7, 2025 | M · derivative | 2,000 | $10.60 | $21,200 | 3,105 | Yes | Form 4 |
| Kaye Edward M. MD | Oct 6, 2025 | Oct 6, 2025 | S | 6,757 | $60.00 | Sale −$405,420 | 9,778 | Yes | Form 4 |
| Blum Robert IPresident & CEO | Oct 1, 2025 | Oct 1, 2025 | S | 5,000 | $55.05 | Sale −$275,250 | 368,108 | Yes | Form 4 |
| Kaye Edward M. MD | Sep 30, 2025 | Sep 30, 2025 | S | 6,695 | $55.08 | Sale −$368,761 | 16,535 | Yes | Form 4 |
| Malik Fady IbrahamEVP Research & Development | Sep 23, 2025 | Sep 23, 2025 | M | 2,000 | $10.60 | $21,200 | 142,610 | Yes | Form 4 |
| Malik Fady IbrahamEVP Research & Development | Sep 23, 2025 | Sep 23, 2025 | S | 2,000 | $49.28 | Sale −$98,560 | 140,610 | Yes | Form 4 |
| Malik Fady IbrahamEVP Research & Development | Sep 23, 2025 | Sep 23, 2025 | M · derivative | 2,000 | $10.60 | $21,200 | 5,105 | Yes | Form 4 |
| Blum Robert IPresident & CEO | Sep 15, 2025 | Sep 15, 2025 | S | 5,000 | $49.77 | Sale −$248,850 | 373,108 | Yes | Form 4 |
| Malik Fady IbrahamEVP Research & Development | Sep 9, 2025 | Sep 10, 2025 | M | 2,000 | $10.60 | $21,200 | 142,610 | Yes | Form 4 |
| Malik Fady IbrahamEVP Research & Development | Sep 9, 2025 | Sep 10, 2025 | S | 2,000 | $51.29 | Sale −$102,580 | 140,610 | Yes | Form 4 |
| Malik Fady IbrahamEVP Research & Development | Sep 9, 2025 | Sep 10, 2025 | M · derivative | 2,000 | $10.60 | $21,200 | 7,105 | Yes | Form 4 |
| Blum Robert IPresident & CEO | Sep 2, 2025 | Sep 2, 2025 | S | 5,000 | $48.76 | Sale −$243,800 | 378,108 | Yes | Form 4 |
| Harrington Robert Arthur | Sep 2, 2025 | Sep 2, 2025 | S | 2,150 | $48.67 | Sale −$104,641 | 20,493 | Yes | Form 4 |
| Kaye Edward M. MD | Sep 2, 2025 | Sep 2, 2025 | S | 6,756 | $50.00 | Sale −$337,800 | 23,230 | Yes | Form 4 |
| Daly James M | Aug 19, 2025 | Aug 20, 2025 | A · derivative | 27,450 | $37.84 | $1,038,708 | 27,450 | No | Form 4 |
| Malik Fady IbrahamEVP Research & Development | Aug 19, 2025 | Aug 19, 2025 | M | 2,000 | $10.60 | $21,200 | 142,610 | Yes | Form 4 |
| Malik Fady IbrahamEVP Research & Development | Aug 19, 2025 | Aug 19, 2025 | S | 2,000 | $38.31 | Sale −$76,620 | 140,610 | Yes | Form 4 |
| Malik Fady IbrahamEVP Research & Development | Aug 19, 2025 | Aug 19, 2025 | M · derivative | 2,000 | $10.60 | $21,200 | 9,105 | Yes | Form 4 |
| Blum Robert IPresident & CEO | Aug 15, 2025 | Aug 15, 2025 | S | 5,000 | $38.42 | Sale −$192,100 | 383,108 | Yes | Form 4 |
| Malik Fady IbrahamEVP Research & Development | Aug 5, 2025 | Aug 5, 2025 | M | 2,000 | $10.60 | $21,200 | 142,610 | Yes | Form 4 |
| Malik Fady IbrahamEVP Research & Development | Aug 5, 2025 | Aug 5, 2025 | S | 2,000 | $36.34 | Sale −$72,680 | 140,610 | Yes | Form 4 |
| Malik Fady IbrahamEVP Research & Development | Aug 5, 2025 | Aug 5, 2025 | M · derivative | 2,000 | $10.60 | $21,200 | 11,105 | Yes | Form 4 |
| Blum Robert IPresident & CEO | Jul 29, 2025 | Jul 31, 2025 | S | 5,000 | $36.45 | Sale −$182,250 | 388,108 | Yes | Form 4 |
| Malik Fady IbrahamEVP Research & Development | Jul 22, 2025 | Jul 23, 2025 | M | 2,000 | $10.60 | $21,200 | 142,610 | Yes | Form 4 |
| Malik Fady IbrahamEVP Research & Development | Jul 22, 2025 | Jul 23, 2025 | S | 2,000 | $37.47 | Sale −$74,940 | 140,610 | Yes | Form 4 |
| Malik Fady IbrahamEVP Research & Development | Jul 22, 2025 | Jul 23, 2025 | M · derivative | 2,000 | $10.60 | $21,200 | 13,105 | Yes | Form 4 |
| Harrington Robert Arthur | Jul 15, 2025 | Jul 16, 2025 | A | 328 | $38.01 | $12,467 | 22,643 | No | Form 4 |
| Kaye Edward M. MD | Jul 15, 2025 | Jul 16, 2025 | A | 328 | $38.01 | $12,467 | 29,986 | No | Form 4 |
| Wierenga Wendall | Jul 15, 2025 | Jul 16, 2025 | A | 164 | $38.01 | $6,234 | 32,345 | No | Form 4 |
| Wysenski Nancy | Jul 15, 2025 | Jul 16, 2025 | A | 164 | $38.01 | $6,234 | 30,774 | No | Form 4 |
| Henderson John T | Jul 15, 2025 | Jul 16, 2025 | A | 559 | $38.01 | $21,248 | 74,240 | No | Form 4 |
| Blum Robert IPresident & CEO | Jul 14, 2025 | Jul 15, 2025 | S | 5,000 | $38.15 | Sale −$190,750 | 393,108 | Yes | Form 4 |
| Malik Fady IbrahamEVP Research & Development | Jul 8, 2025 | Jul 8, 2025 | M | 2,000 | $10.60 | $21,200 | 142,610 | Yes | Form 4 |
| Malik Fady IbrahamEVP Research & Development | Jul 8, 2025 | Jul 8, 2025 | S | 2,000 | $33.76 | Sale −$67,520 | 140,610 | Yes | Form 4 |
| Malik Fady IbrahamEVP Research & Development | Jul 8, 2025 | Jul 8, 2025 | M · derivative | 2,000 | $10.60 | $21,200 | 15,105 | Yes | Form 4 |
| Blum Robert IPresident & CEO | Jul 1, 2025 | Jul 2, 2025 | S | 5,000 | $33.55 | Sale −$167,750 | 398,108 | Yes | Form 4 |
| Malik Fady IbrahamEVP Research & Development | Jun 17, 2025 | Jun 17, 2025 | M | 2,000 | $10.60 | $21,200 | 142,610 | Yes | Form 4 |
| Malik Fady IbrahamEVP Research & Development | Jun 17, 2025 | Jun 17, 2025 | S | 2,000 | $32.91 | Sale −$65,820 | 140,610 | Yes | Form 4 |
| Malik Fady IbrahamEVP Research & Development | Jun 17, 2025 | Jun 17, 2025 | M · derivative | 2,000 | $10.60 | $21,200 | 17,105 | Yes | Form 4 |
| Blum Robert IPresident & CEO | Jun 16, 2025 | Jun 16, 2025 | S | 5,000 | $33.80 | Sale −$169,000 | 403,108 | Yes | Form 4 |
| Callos AndrewEVP, Chief Commercial Officer | Jun 5, 2025 | Jun 5, 2025 | S | 8,659 | $32.04 | Sale −$277,434 | 52,028 | Yes | Form 4 |
| Kaye Edward M. MD | Jun 5, 2025 | Jun 5, 2025 | S | 3,636 | $32.10 | Sale −$116,716 | 29,658 | Yes | Form 4 |
| Malik Fady IbrahamEVP Research & Development | Jun 3, 2025 | Jun 3, 2025 | M | 2,000 | $10.60 | $21,200 | 142,610 | Yes | Form 4 |
| Malik Fady IbrahamEVP Research & Development | Jun 3, 2025 | Jun 3, 2025 | S | 2,000 | $31.88 | Sale −$63,760 | 140,610 | Yes | Form 4 |
| Malik Fady IbrahamEVP Research & Development | Jun 3, 2025 | Jun 3, 2025 | M · derivative | 2,000 | $10.60 | $21,200 | 19,105 | Yes | Form 4 |
| Lee SungEVP, Chief Financial Officer | Jun 2, 2025 | Jun 3, 2025 | F | 4,965 | $31.21 | $154,958 | 69,477 | No | Form 4 |
| Blum Robert IPresident & CEO | Jun 2, 2025 | Jun 2, 2025 | S | 5,000 | $31.22 | Sale −$156,100 | 408,108 | Yes | Form 4 |
| Malik Fady IbrahamEVP Research & Development | May 20, 2025 | May 20, 2025 | M | 2,000 | $10.60 | $21,200 | 142,255 | Yes | Form 4 |
| Malik Fady IbrahamEVP Research & Development | May 20, 2025 | May 20, 2025 | S | 2,000 | $31.98 | Sale −$63,960 | 140,255 | Yes | Form 4 |
| Malik Fady IbrahamEVP Research & Development | May 20, 2025 | May 20, 2025 | M · derivative | 2,000 | $10.60 | $21,200 | 21,105 | Yes | Form 4 |
| Harrington Robert Arthur | May 14, 2025 | May 19, 2025 | A | 7,333 | $0.00 | $0 | 22,315 | No | Form 4 |
| Harrington Robert Arthur | May 14, 2025 | May 19, 2025 | A · derivative | 10,880 | $30.00 | $326,400 | 10,880 | No | Form 4 |
| Blum Robert IPresident & CEO | May 16, 2025 | May 16, 2025 | S | 5,000 | $30.93 | Sale −$154,650 | 412,629 | Yes | Form 4 |
| Bhanji Muna | May 15, 2025 | May 15, 2025 | S | 1,454 | $29.73 | Sale −$43,227 | 23,510 | Yes | Form 4 |
| Parshall B Lynne | May 14, 2025 | May 15, 2025 | A | 7,333 | $0.00 | $0 | 27,933 | No | Form 4 |
| Parshall B Lynne | May 14, 2025 | May 15, 2025 | A · derivative | 10,880 | $30.00 | $326,400 | 10,880 | No | Form 4 |
| Wysenski Nancy | May 14, 2025 | May 14, 2025 | A | 7,333 | $0.00 | $0 | 30,610 | No | Form 4 |
| Wysenski Nancy | May 14, 2025 | May 14, 2025 | A · derivative | 10,880 | $30.00 | $326,400 | 10,880 | No | Form 4 |
| Wierenga Wendall | May 14, 2025 | May 14, 2025 | A | 7,333 | $0.00 | $0 | 32,181 | No | Form 4 |
| Wierenga Wendall | May 14, 2025 | May 14, 2025 | A · derivative | 10,880 | $30.00 | $326,400 | 10,880 | No | Form 4 |
| Landry Robert E | May 14, 2025 | May 14, 2025 | A | 7,333 | $0.00 | $0 | 7,333 | No | Form 4 |
| Landry Robert E | May 14, 2025 | May 14, 2025 | A · derivative | 10,880 | $30.00 | $326,400 | 10,880 | No | Form 4 |
| Kaye Edward M. MD | May 14, 2025 | May 14, 2025 | A | 7,333 | $0.00 | $0 | 33,294 | No | Form 4 |
| Kaye Edward M. MD | May 14, 2025 | May 14, 2025 | A · derivative | 10,880 | $30.00 | $326,400 | 10,880 | No | Form 4 |
| Henderson John T | May 14, 2025 | May 14, 2025 | A | 7,333 | $0.00 | $0 | 73,681 | No | Form 4 |
| Henderson John T | May 14, 2025 | May 14, 2025 | A · derivative | 10,880 | $30.00 | $326,400 | 10,880 | No | Form 4 |
| Bhanji Muna | May 14, 2025 | May 14, 2025 | A | 7,333 | $0.00 | $0 | 24,964 | No | Form 4 |
| Bhanji Muna | May 14, 2025 | May 14, 2025 | A · derivative | 10,880 | $30.00 | $326,400 | 10,880 | No | Form 4 |
| Malik Fady IbrahamEVP Research & Development | May 6, 2025 | May 6, 2025 | M | 2,000 | $10.60 | $21,200 | 142,255 | Yes | Form 4 |
| Malik Fady IbrahamEVP Research & Development | May 6, 2025 | May 6, 2025 | S | 2,000 | $35.01 | Sale −$70,020 | 140,255 | Yes | Form 4 |
| Malik Fady IbrahamEVP Research & Development | May 6, 2025 | May 6, 2025 | M · derivative | 2,000 | $10.60 | $21,200 | 23,105 | Yes | Form 4 |
| Callos AndrewEVP, Chief Commercial Officer | May 5, 2025 | May 5, 2025 | S | 4,002 | $36.68 | Sale −$146,793 | 60,687 | Yes | Form 4 |
| Blum Robert IPresident & CEO | Apr 29, 2025 | Apr 29, 2025 | S | 5,000 | $40.96 | Sale −$204,800 | 417,629 | Yes | Form 4 |
| Malik Fady IbrahamEVP Research & Development | Apr 22, 2025 | Apr 22, 2025 | M | 2,000 | $10.60 | $21,200 | 142,255 | Yes | Form 4 |
| Malik Fady IbrahamEVP Research & Development | Apr 22, 2025 | Apr 22, 2025 | S | 2,000 | $38.11 | Sale −$76,220 | 140,255 | Yes | Form 4 |
| Malik Fady IbrahamEVP Research & Development | Apr 22, 2025 | Apr 22, 2025 | M · derivative | 2,000 | $10.60 | $21,200 | 25,105 | Yes | Form 4 |
| Wierenga Wendall | Apr 21, 2025 | Apr 21, 2025 | M | 20,000 | $6.21 | $124,200 | 44,848 | Yes | Form 4 |
| Wierenga Wendall | Apr 21, 2025 | Apr 21, 2025 | S | 20,000 | $38.46 | Sale −$769,200 | 24,848 | Yes | Form 4 |
| Wierenga Wendall | Apr 21, 2025 | Apr 21, 2025 | M · derivative | 20,000 | $6.21 | $124,200 | not reported | Yes | Form 4 |
| Wysenski Nancy | Apr 15, 2025 | Apr 16, 2025 | A | 162 | $38.56 | $6,247 | 23,277 | No | Form 4 |
| Wierenga Wendall | Apr 15, 2025 | Apr 16, 2025 | A | 162 | $38.56 | $6,247 | 24,848 | No | Form 4 |
| Kaye Edward M. MD | Apr 15, 2025 | Apr 16, 2025 | A | 324 | $38.56 | $12,493 | 25,961 | No | Form 4 |
| Harrington Robert Arthur | Apr 15, 2025 | Apr 16, 2025 | A | 324 | $38.56 | $12,493 | 14,982 | No | Form 4 |
| Henderson John T | Apr 15, 2025 | Apr 16, 2025 | A | 551 | $38.56 | $21,247 | 66,348 | No | Form 4 |
| Henderson John T | Apr 15, 2025 | Apr 16, 2025 | M | 20,000 | $6.21 | $124,200 | 69,538 | Yes | Form 4 |
| Henderson John T | Apr 15, 2025 | Apr 16, 2025 | S | 3,190 | $38.66 | Sale −$123,325 | 66,348 | Yes | Form 4 |
| Henderson John T | Apr 15, 2025 | Apr 16, 2025 | M · derivative | 20,000 | $6.21 | $124,200 | not reported | Yes | Form 4 |
| Blum Robert IPresident & CEO | Apr 10, 2025 | Apr 10, 2025 | S | 5,000 | $36.77 | Sale −$183,850 | 422,629 | Yes | Form 4 |
| Malik Fady IbrahamEVP Research & Development | Apr 8, 2025 | Apr 8, 2025 | M | 2,000 | $10.60 | $21,200 | 142,255 | Yes | Form 4 |
| Malik Fady IbrahamEVP Research & Development | Apr 8, 2025 | Apr 8, 2025 | S | 2,000 | $36.18 | Sale −$72,360 | 140,255 | Yes | Form 4 |
| Malik Fady IbrahamEVP Research & Development | Apr 8, 2025 | Apr 8, 2025 | M · derivative | 2,000 | $10.60 | $21,200 | 27,105 | Yes | Form 4 |
| Callos AndrewEVP, Chief Commercial Officer | Apr 7, 2025 | Apr 7, 2025 | S | 2,886 | $35.78 | Sale −$103,261 | 64,689 | Yes | Form 4 |
| Harrington Robert Arthur | Apr 3, 2025 | Apr 4, 2025 | S | 450 | $39.43 | Sale −$17,744 | 14,658 | Yes | Form 4 |
| Blum Robert IPresident & CEO | Mar 31, 2025 | Mar 31, 2025 | S | 15,000 | $40.75 | Sale −$611,250 | 427,629 | Yes | Form 4 |
| Malik Fady IbrahamEVP Research & Development | Mar 19, 2025 | Mar 19, 2025 | G | 200 | $0.00 | $0 | 140,255 | No | Form 4 |
| Malik Fady IbrahamEVP Research & Development | Mar 18, 2025 | Mar 18, 2025 | M | 2,000 | $10.60 | $21,200 | 142,455 | Yes | Form 4 |
| Malik Fady IbrahamEVP Research & Development | Mar 18, 2025 | Mar 18, 2025 | S | 2,000 | $43.58 | Sale −$87,160 | 140,455 | Yes | Form 4 |
| Malik Fady IbrahamEVP Research & Development | Mar 18, 2025 | Mar 18, 2025 | M · derivative | 2,000 | $10.60 | $21,200 | 29,105 | Yes | Form 4 |
| Blum Robert IPresident & CEO | Mar 14, 2025 | Mar 18, 2025 | A | 116,096 | $0.00 | $0 | 480,277 | No | Form 4 |
| Blum Robert IPresident & CEO | Mar 14, 2025 | Mar 18, 2025 | A · derivative | 2,254 | $44.36 | $99,987 | 2,254 | No | Form 4 |
| Blum Robert IPresident & CEO | Mar 14, 2025 | Mar 18, 2025 | A · derivative | 176,547 | $44.36 | $7,831,625 | 176,547 | No | Form 4 |
| Malik Fady IbrahamEVP Research & Development | Mar 14, 2025 | Mar 18, 2025 | A | 39,450 | $0.00 | $0 | 144,844 | No | Form 4 |
| Malik Fady IbrahamEVP Research & Development | Mar 14, 2025 | Mar 18, 2025 | A · derivative | 2,293 | $44.36 | $101,717 | 2,293 | No | Form 4 |
| Malik Fady IbrahamEVP Research & Development | Mar 14, 2025 | Mar 18, 2025 | A · derivative | 58,465 | $44.36 | $2,593,507 | 58,465 | No | Form 4 |
| Callos AndrewEVP, Chief Commercial Officer | Mar 14, 2025 | Mar 18, 2025 | A | 32,687 | $0.00 | $0 | 70,350 | No | Form 4 |
| Callos AndrewEVP, Chief Commercial Officer | Mar 14, 2025 | Mar 18, 2025 | A · derivative | 2,749 | $44.36 | $121,946 | 2,749 | No | Form 4 |
| Callos AndrewEVP, Chief Commercial Officer | Mar 14, 2025 | Mar 18, 2025 | A · derivative | 47,593 | $44.36 | $2,111,225 | 47,593 | No | Form 4 |
| Lee SungEVP, Chief Financial Officer | Mar 14, 2025 | Mar 18, 2025 | A | 32,687 | $0.00 | $0 | 74,442 | No | Form 4 |
| Lee SungEVP, Chief Financial Officer | Mar 14, 2025 | Mar 18, 2025 | A · derivative | 9,016 | $44.36 | $399,950 | 9,016 | No | Form 4 |
| Lee SungEVP, Chief Financial Officer | Mar 14, 2025 | Mar 18, 2025 | A · derivative | 41,326 | $44.36 | $1,833,221 | 41,326 | No | Form 4 |
| Callos AndrewEVP, Chief Commercial Officer | Mar 17, 2025 | Mar 17, 2025 | M | 20,900 | $23.26 | $486,134 | 58,563 | Yes | Form 4 |
| Callos AndrewEVP, Chief Commercial Officer | Mar 17, 2025 | Mar 17, 2025 | S | 20,900 | $45.14 | Sale −$943,426 | 37,663 | Yes | Form 4 |
| Callos AndrewEVP, Chief Commercial Officer | Mar 17, 2025 | Mar 17, 2025 | M · derivative | 20,900 | $23.26 | $486,134 | 129,000 | Yes | Form 4 |
| Blum Robert IPresident & CEO | Mar 17, 2025 | Mar 17, 2025 | S | 25,000 | $44.65 | Sale −$1,116,250 | 339,181 | Yes | Form 4 |
| Blum Robert IPresident & CEO | Mar 17, 2025 | Mar 17, 2025 | S | 12,648 | $44.38 | Sale −$561,318 | 326,533 | No | Form 4 |
| Malik Fady IbrahamEVP Research & Development | Mar 17, 2025 | Mar 17, 2025 | S | 4,389 | $44.38 | Sale −$194,784 | 101,005 | No | Form 4 |
| Callos AndrewEVP, Chief Commercial Officer | Mar 17, 2025 | Mar 17, 2025 | S | 2,775 | $44.38 | Sale −$123,155 | 34,888 | No | Form 4 |
| Callos AndrewEVP, Chief Commercial Officer | Mar 14, 2025 | Mar 14, 2025 | M | 100 | $23.26 | $2,326 | 37,763 | Yes | Form 4 |
| Callos AndrewEVP, Chief Commercial Officer | Mar 14, 2025 | Mar 14, 2025 | S | 100 | $45.00 | Sale −$4,500 | 37,663 | Yes | Form 4 |
| Callos AndrewEVP, Chief Commercial Officer | Mar 14, 2025 | Mar 14, 2025 | M · derivative | 100 | $23.26 | $2,326 | 149,900 | Yes | Form 4 |
| Callos AndrewEVP, Chief Commercial Officer | Mar 13, 2025 | Mar 13, 2025 | S | 26,771 | $43.62 | Sale −$1,167,751 | 37,663 | Yes | Form 4 |
| Blum Robert IPresident & CEO | Mar 6, 2025 | Mar 7, 2025 | S | 16,970 | $43.44 | Sale −$737,177 | 364,181 | No | Form 4 |
| Malik Fady IbrahamEVP Research & Development | Mar 6, 2025 | Mar 7, 2025 | S | 8,228 | $43.27 | Sale −$356,026 | 105,394 | No | Form 4 |
| Callos AndrewEVP, Chief Commercial Officer | Mar 6, 2025 | Mar 7, 2025 | S | 3,341 | $43.27 | Sale −$144,565 | 64,434 | No | Form 4 |
| Blum Robert IPresident & CEO | Mar 5, 2025 | Mar 5, 2025 | S | 25,000 | $43.23 | Sale −$1,080,750 | 381,151 | Yes | Form 4 |
| Blum Robert IPresident & CEO | Mar 3, 2025 | Mar 5, 2025 | S | 8,743 | $42.88 | Sale −$374,900 | 406,151 | No | Form 4 |
| Callos AndrewEVP, Chief Commercial Officer | Mar 3, 2025 | Mar 5, 2025 | S | 1,114 | $42.88 | Sale −$47,768 | 67,775 | No | Form 4 |
| Malik Fady IbrahamEVP Research & Development | Mar 3, 2025 | Mar 5, 2025 | S | 2,449 | $42.88 | Sale −$105,013 | 113,622 | No | Form 4 |
| Harrington Robert Arthur | Mar 4, 2025 | Mar 4, 2025 | S | 900 | $42.50 | Sale −$38,250 | 15,108 | Yes | Form 4 |
| Malik Fady IbrahamEVP Research & Development | Mar 4, 2025 | Mar 4, 2025 | M | 2,000 | $10.60 | $21,200 | 118,071 | Yes | Form 4 |
| Malik Fady IbrahamEVP Research & Development | Mar 4, 2025 | Mar 4, 2025 | S | 2,000 | $42.50 | Sale −$85,000 | 116,071 | Yes | Form 4 |
| Malik Fady IbrahamEVP Research & Development | Mar 4, 2025 | Mar 4, 2025 | M · derivative | 2,000 | $10.60 | $21,200 | 31,105 | Yes | Form 4 |
| Malik Fady IbrahamEVP Research & Development | Feb 18, 2025 | Feb 18, 2025 | M | 2,000 | $10.60 | $21,200 | 118,071 | Yes | Form 4 |
| Malik Fady IbrahamEVP Research & Development | Feb 18, 2025 | Feb 18, 2025 | S | 2,000 | $45.98 | Sale −$91,960 | 116,071 | Yes | Form 4 |
| Malik Fady IbrahamEVP Research & Development | Feb 18, 2025 | Feb 18, 2025 | M · derivative | 2,000 | $10.60 | $21,200 | 33,105 | Yes | Form 4 |
| Landry Robert E | Feb 10, 2025 | Feb 11, 2025 | A · derivative | 25,538 | $42.21 | $1,077,959 | 25,538 | No | Form 4 |
| Malik Fady IbrahamEVP Research & Development | Feb 4, 2025 | Feb 4, 2025 | M | 2,000 | $10.60 | $21,200 | 118,071 | Yes | Form 4 |
| Malik Fady IbrahamEVP Research & Development | Feb 4, 2025 | Feb 4, 2025 | S | 2,000 | $48.06 | Sale −$96,120 | 116,071 | Yes | Form 4 |
| Malik Fady IbrahamEVP Research & Development | Feb 4, 2025 | Feb 4, 2025 | M · derivative | 2,000 | $10.60 | $21,200 | 35,105 | Yes | Form 4 |
| Malik Fady IbrahamEVP Research & Development | Jan 21, 2025 | Jan 21, 2025 | M | 2,000 | $10.60 | $21,200 | 118,071 | Yes | Form 4 |
| Malik Fady IbrahamEVP Research & Development | Jan 21, 2025 | Jan 21, 2025 | S | 2,000 | $45.92 | Sale −$91,840 | 116,071 | Yes | Form 4 |
| Malik Fady IbrahamEVP Research & Development | Jan 21, 2025 | Jan 21, 2025 | M · derivative | 2,000 | $10.60 | $21,200 | 37,105 | Yes | Form 4 |
| Malik Fady IbrahamEVP Research & Development | Jan 7, 2025 | Jan 10, 2025 | M | 2,000 | $10.60 | $21,200 | 118,071 | Yes | Form 4 |
| Malik Fady IbrahamEVP Research & Development | Jan 7, 2025 | Jan 10, 2025 | S | 2,000 | $49.32 | Sale −$98,640 | 116,071 | Yes | Form 4 |
| Malik Fady IbrahamEVP Research & Development | Jan 7, 2025 | Jan 10, 2025 | M · derivative | 2,000 | $10.60 | $21,200 | 39,105 | Yes | Form 4 |
| Wierenga Wendall | Jan 2, 2025 | Jan 6, 2025 | A | 127 | $48.93 | $6,214 | 24,686 | No | Form 4 |
| Wysenski Nancy | Jan 2, 2025 | Jan 6, 2025 | A | 127 | $48.93 | $6,214 | 23,115 | No | Form 4 |
| Kaye Edward M. MD | Jan 2, 2025 | Jan 6, 2025 | A | 255 | $48.93 | $12,477 | 25,637 | No | Form 4 |
| Harrington Robert Arthur | Jan 2, 2025 | Jan 6, 2025 | A | 255 | $48.93 | $12,477 | 16,008 | No | Form 4 |
| Henderson John T | Jan 2, 2025 | Jan 6, 2025 | A | 434 | $48.93 | $21,236 | 48,987 | No | Form 4 |
| Wierenga Wendall | Dec 16, 2024 | Dec 16, 2024 | M | 742 | $7.37 | $5,469 | 25,301 | Yes | Form 4 |
| Wierenga Wendall | Dec 16, 2024 | Dec 16, 2024 | S | 742 | $48.61 | Sale −$36,069 | 24,559 | Yes | Form 4 |
| Wierenga Wendall | Dec 16, 2024 | Dec 16, 2024 | M · derivative | 742 | $7.37 | $5,469 | not reported | Yes | Form 4 |
| Henderson John T | Dec 11, 2024 | Dec 12, 2024 | M | 1,780 | $7.37 | $13,119 | 40,241 | Yes | Form 4 |
| Henderson John T | Dec 11, 2024 | Dec 12, 2024 | S | 1,780 | $50.42 | Sale −$89,748 | 38,461 | Yes | Form 4 |
| Henderson John T | Dec 11, 2024 | Dec 12, 2024 | M | 10,092 | $7.37 | $74,378 | 48,553 | Yes | Form 4 |
| Henderson John T | Dec 11, 2024 | Dec 12, 2024 | M · derivative | 1,780 | $7.37 | $13,119 | 10,092 | Yes | Form 4 |
| Henderson John T | Dec 11, 2024 | Dec 12, 2024 | M · derivative | 10,092 | $7.37 | $74,378 | not reported | Yes | Form 4 |
| Malik Fady IbrahamEVP Research & Development | Dec 10, 2024 | Dec 10, 2024 | M | 5,300 | $7.96 | $42,188 | 123,371 | Yes | Form 4 |
| Malik Fady IbrahamEVP Research & Development | Dec 10, 2024 | Dec 10, 2024 | S | 5,300 | $50.63 | Sale −$268,339 | 118,071 | Yes | Form 4 |
| Malik Fady IbrahamEVP Research & Development | Dec 10, 2024 | Dec 10, 2024 | S | 2,000 | $50.65 | Sale −$101,300 | 116,071 | Yes | Form 4 |
| Malik Fady IbrahamEVP Research & Development | Dec 10, 2024 | Dec 10, 2024 | M · derivative | 5,300 | $7.96 | $42,188 | not reported | Yes | Form 4 |
| Blum Robert IPresident & CEO | Dec 3, 2024 | Dec 5, 2024 | A | 11,529 | $0.00 | $0 | 409,207 | No | Form 4 |
| Blum Robert IPresident & CEO | Dec 3, 2024 | Dec 5, 2024 | F | 5,843 | $51.51 | $300,973 | 403,364 | No | Form 4 |
| Blum Robert IPresident & CEO | Dec 3, 2024 | Dec 5, 2024 | A | 11,530 | $0.00 | $0 | 414,894 | No | Form 4 |
| Callos AndrewEVP, Chief Commercial Officer | Dec 3, 2024 | Dec 5, 2024 | A | 3,176 | $0.00 | $0 | 67,063 | No | Form 4 |
| Callos AndrewEVP, Chief Commercial Officer | Dec 3, 2024 | Dec 5, 2024 | F | 1,351 | $51.51 | $69,590 | 65,712 | No | Form 4 |
| Callos AndrewEVP, Chief Commercial Officer | Dec 3, 2024 | Dec 5, 2024 | A | 3,177 | $0.00 | $0 | 68,889 | No | Form 4 |
| Malik Fady IbrahamEVP Research & Development | Dec 3, 2024 | Dec 5, 2024 | A | 4,000 | $0.00 | $0 | 116,099 | No | Form 4 |
| Malik Fady IbrahamEVP Research & Development | Dec 3, 2024 | Dec 5, 2024 | F | 2,028 | $51.51 | $104,462 | 114,071 | No | Form 4 |
| Malik Fady IbrahamEVP Research & Development | Dec 3, 2024 | Dec 5, 2024 | A | 4,000 | $0.00 | $0 | 118,071 | No | Form 4 |
| Lee SungEVP, Chief Financial Officer | Dec 3, 2024 | Dec 5, 2024 | A | 4,303 | $0.00 | $0 | 38,987 | No | Form 4 |
| Lee SungEVP, Chief Financial Officer | Dec 3, 2024 | Dec 5, 2024 | F | 1,536 | $51.51 | $79,119 | 37,451 | No | Form 4 |
| Lee SungEVP, Chief Financial Officer | Dec 3, 2024 | Dec 5, 2024 | A | 4,304 | $0.00 | $0 | 41,755 | No | Form 4 |
| Wong RobertVP, Chief Accounting Officer | Dec 3, 2024 | Dec 5, 2024 | A | 764 | $0.00 | $0 | 18,162 | No | Form 4 |
| Wong RobertVP, Chief Accounting Officer | Dec 3, 2024 | Dec 5, 2024 | F | 273 | $51.51 | $14,062 | 17,889 | No | Form 4 |
| Wong RobertVP, Chief Accounting Officer | Dec 3, 2024 | Dec 5, 2024 | A | 766 | $0.00 | $0 | 18,655 | No | Form 4 |
| Blum Robert IPresident & CEO | Dec 2, 2024 | Dec 2, 2024 | M | 5,000 | $6.67 | $33,350 | 402,678 | Yes | Form 4 |
| Blum Robert IPresident & CEO | Dec 2, 2024 | Dec 2, 2024 | S | 5,000 | $50.76 | Sale −$253,800 | 397,678 | Yes | Form 4 |
| Blum Robert IPresident & CEO | Dec 2, 2024 | Dec 2, 2024 | M · derivative | 5,000 | $6.67 | $33,350 | 54,727 | Yes | Form 4 |
| Malik Fady IbrahamEVP Research & Development | Nov 26, 2024 | Nov 26, 2024 | M | 5,300 | $7.96 | $42,188 | 119,178 | Yes | Form 4 |
| Malik Fady IbrahamEVP Research & Development | Nov 26, 2024 | Nov 26, 2024 | S | 5,300 | $50.17 | Sale −$265,901 | 113,878 | Yes | Form 4 |
| Malik Fady IbrahamEVP Research & Development | Nov 26, 2024 | Nov 26, 2024 | S | 2,000 | $50.14 | Sale −$100,280 | 111,878 | Yes | Form 4 |
| Malik Fady IbrahamEVP Research & Development | Nov 26, 2024 | Nov 26, 2024 | M · derivative | 5,300 | $7.96 | $42,188 | 5,300 | Yes | Form 4 |
| Wierenga Wendall | Nov 25, 2024 | Nov 26, 2024 | M | 742 | $7.37 | $5,469 | 25,301 | Yes | Form 4 |
| Wierenga Wendall | Nov 25, 2024 | Nov 26, 2024 | S | 742 | $50.00 | Sale −$37,100 | 24,559 | Yes | Form 4 |
| Wierenga Wendall | Nov 25, 2024 | Nov 26, 2024 | M · derivative | 742 | $7.37 | $5,469 | 742 | Yes | Form 4 |
| Blum Robert IPresident & CEO | Nov 18, 2024 | Nov 19, 2024 | M | 5,000 | $6.67 | $33,350 | 402,456 | Yes | Form 4 |
| Blum Robert IPresident & CEO | Nov 18, 2024 | Nov 19, 2024 | S | 5,000 | $50.55 | Sale −$252,750 | 397,456 | Yes | Form 4 |