DFTXDefinium Therapeutics, Inc.
- Market cap
- $4.79B
- as of 2026-10-23
- Latest close
- $35.67
- as of 2026-10-23
- Sector
- Healthcare
- as of 2026-10-24
- Industry
- Biotechnology
- as of 2026-10-24
Cluster
No cluster in the last 90 days under the default rule (14d · ≥2 insiders · all roles).
Form 4 historysince 2023-12-26
| Insider | Traded | Filed | Type | Shares | Price | Value | Owned after | 10b5-1 plan | Filing |
|---|---|---|---|---|---|---|---|---|---|
| Roberts BrandiChief Financial Officer | Sep 25 | Sep 29 | S | 3,377 | $36.57 | Sale −$123,497 | 394,528 | Yes | Form 4 |
| Sullivan MarkChief Legal Officer | Sep 25 | Sep 29 | S | 14,051 | $36.57 | Sale −$513,845 | 494,228 | Yes | Form 4 |
| Wiley Matthew T.Chief Commercial Officer | Sep 25 | Sep 29 | S | 3,097 | $36.57 | Sale −$113,257 | 359,036 | Yes | Form 4 |
| Barrow RobertChief Executive Officer | Sep 25 | Sep 29 | S | 31,550 | $36.57 | Sale −$1,153,784 | 2,213,090 | Yes | Form 4 |
| Karlin DanielChief Medical Officer | Sep 25 | Sep 29 | S | 10,853 | $36.57 | Sale −$396,894 | 792,846 | Yes | Form 4 |
| Vallone Carol A | Sep 18 | Sep 18 | M | 1,086 | $35.52 | $38,575 | 22,296 | No | Form 4 |
| Vallone Carol A | Sep 18 | Sep 18 | M · derivative | 1,086 | $35.52 | $38,575 | not reported | No | Form 4 |
| Krebs Andreas | Sep 18 | Sep 18 | M | 1,629 | $35.52 | $57,862 | 21,402 | No | Form 4 |
| Krebs Andreas | Sep 18 | Sep 18 | M · derivative | 1,629 | $35.52 | $57,862 | not reported | No | Form 4 |
| Barrow RobertChief Executive Officer | Sep 14 | Sep 14 | A | 750,000 | $0.00 | $0 | 2,244,640 | No | Form 4 |
| Roberts BrandiChief Financial Officer | Sep 14 | Sep 14 | A | 125,000 | $0.00 | $0 | 397,905 | No | Form 4 |
| Sullivan MarkChief Legal Officer | Sep 14 | Sep 14 | A | 125,000 | $0.00 | $0 | 508,279 | No | Form 4 |
| Wiley Matthew T.Chief Commercial Officer | Sep 14 | Sep 14 | A | 125,000 | $0.00 | $0 | 362,133 | No | Form 4 |
| Karlin DanielChief Medical Officer | Sep 14 | Sep 14 | A | 200,000 | $0.00 | $0 | 803,699 | No | Form 4 |
| Barrow RobertChief Executive Officer | Sep 3 | Sep 4 | S | 19,023 | $37.94 | Sale −$721,733 | 1,494,640 | Yes | Form 4 |
| Barrow RobertChief Executive Officer | Sep 2 | Sep 4 | A | 40,000 | $0.00 | $0 | 1,513,663 | Yes | Form 4 |
| Roberts BrandiChief Financial Officer | Aug 12 | Aug 12 | A | 62,500 | $0.00 | $0 | 271,987 | No | Form 4 |
| Wiley Matthew T.Chief Commercial Officer | Aug 12 | Aug 12 | A | 62,500 | $0.00 | $0 | 237,133 | No | Form 4 |
| Sullivan MarkChief Legal Officer | Aug 12 | Aug 12 | A | 62,500 | $0.00 | $0 | 383,071 | No | Form 4 |
| Karlin DanielChief Medical Officer | Aug 12 | Aug 12 | A | 100,000 | $0.00 | $0 | 603,282 | No | Form 4 |
| Barrow RobertChief Executive Officer | Aug 12 | Aug 12 | A | 375,000 | $0.00 | $0 | 1,473,246 | No | Form 4 |
| Wiley Matthew T.Chief Commercial Officer | Jun 25 | Jun 26 | S | 2,867 | $45.03 | Sale −$129,101 | 174,633 | Yes | Form 4 |
| Barrow RobertChief Executive Officer | Jun 25 | Jun 26 | S | 29,208 | $45.03 | Sale −$1,315,236 | 1,098,246 | Yes | Form 4 |
| Roberts BrandiChief Financial Officer | Jun 25 | Jun 26 | S | 3,013 | $45.03 | Sale −$135,675 | 209,487 | Yes | Form 4 |
| Karlin DanielChief Medical Officer | Jun 25 | Jun 26 | S | 10,035 | $45.03 | Sale −$451,876 | 503,282 | Yes | Form 4 |
| Sullivan MarkChief Legal Officer | Jun 25 | Jun 26 | S | 13,008 | $45.03 | Sale −$585,750 | 320,571 | Yes | Form 4 |
| Karlin DanielChief Medical Officer | Jun 22 | Jun 22 | A | 100,000 | $0.00 | $0 | 513,317 | No | Form 4 |
| Sullivan MarkChief Legal Officer | Jun 22 | Jun 22 | A | 62,500 | $0.00 | $0 | 333,579 | No | Form 4 |
| Roberts BrandiChief Financial Officer | Jun 22 | Jun 22 | A | 62,500 | $0.00 | $0 | 212,500 | No | Form 4 |
| Wiley Matthew T.Chief Commercial Officer | Jun 22 | Jun 22 | A | 62,500 | $0.00 | $0 | 177,500 | No | Form 4 |
| Barrow RobertChief Executive Officer | Jun 22 | Jun 22 | A | 375,000 | $0.00 | $0 | 1,127,454 | No | Form 4 |
| Bruhn Suzanne Louise | Jun 11 | Jun 15 | A | 4,666 | $0.00 | $0 | 24,289 | No | Form 4 |
| Bruhn Suzanne Louise | Jun 11 | Jun 15 | A · derivative | 19,188 | $24.11 | $462,623 | 19,188 | No | Form 4 |
| Adsett Roger | Jun 11 | Jun 15 | A | 3,555 | $0.00 | $0 | 3,555 | No | Form 4 |
| Adsett Roger | Jun 11 | Jun 15 | A · derivative | 14,620 | $24.11 | $352,488 | 14,620 | No | Form 4 |
| Krebs Andreas | Jun 11 | Jun 15 | A | 4,666 | $0.00 | $0 | 19,773 | No | Form 4 |
| Krebs Andreas | Jun 11 | Jun 15 | A · derivative | 19,188 | $24.11 | $462,623 | 19,188 | No | Form 4 |
| Vallone Carol A | Jun 11 | Jun 15 | A | 4,666 | $0.00 | $0 | 21,210 | No | Form 4 |
| Vallone Carol A | Jun 11 | Jun 15 | A · derivative | 19,188 | $24.11 | $462,623 | 19,188 | No | Form 4 |
| Gryska David W | Jun 11 | Jun 15 | A | 4,666 | $0.00 | $0 | 19,900 | No | Form 4 |
| Gryska David W | Jun 11 | Jun 15 | A · derivative | 19,188 | $24.11 | $462,623 | 19,188 | No | Form 4 |
| Crystal Roger | Jun 11 | Jun 15 | A | 4,666 | $0.00 | $0 | 24,289 | No | Form 4 |
| Crystal Roger | Jun 11 | Jun 15 | A · derivative | 19,188 | $24.11 | $462,623 | 19,188 | No | Form 4 |
| Barrow RobertChief Executive Officer | Mar 25 | Mar 26 | S | 24,431 | $18.47 | Sale −$451,241 | 752,454 | Yes | Form 4 |
| Sullivan MarkChief Legal Officer | Mar 25 | Mar 26 | S | 10,702 | $18.47 | Sale −$197,666 | 271,079 | Yes | Form 4 |
| Karlin DanielChief Medical Officer | Mar 25 | Mar 26 | S | 8,018 | $18.47 | Sale −$148,092 | 413,317 | Yes | Form 4 |
| Barrow RobertChief Executive Officer | Feb 3 | Feb 5 | A | 320,000 | $0.00 | $0 | 1,098,477 | No | Form 4 |
| Karlin DanielChief Medical Officer | Feb 3 | Feb 5 | A | 150,000 | $0.00 | $0 | 575,025 | No | Form 4 |
| Sullivan MarkChief Legal Officer | Feb 3 | Feb 5 | A | 125,000 | $0.00 | $0 | 407,576 | No | Form 4 |
| Roberts BrandiChief Financial Officer | Feb 3 | Feb 5 | A | 150,000 | $0.00 | $0 | 150,000 | No | Form 4 |
| Wiley Matthew T.Chief Commercial Officer | Feb 3 | Feb 5 | A | 115,000 | $0.00 | $0 | 115,000 | No | Form 4 |
| Adsett Roger | Jan 29 | Jan 29 | A · derivative | 50,000 | $17.24 | $862,000 | 50,000 | No | Form 4 |
| Sullivan MarkChief Legal Officer | Dec 26, 2025 | Dec 29, 2025 | S | 11,276 | $13.15 | Sale −$148,279 | 282,576 | Yes | Form 4 |
| Barrow RobertChief Executive Officer | Dec 26, 2025 | Dec 29, 2025 | S | 25,791 | $13.15 | Sale −$339,152 | 778,477 | Yes | Form 4 |
| Karlin DanielChief Medical Officer | Dec 26, 2025 | Dec 29, 2025 | S | 5,600 | $13.15 | Sale −$73,640 | 425,025 | Yes | Form 4 |
| Karlin DanielChief Medical Officer | Sep 25, 2025 | Sep 26, 2025 | S | 7,704 | $9.77 | Sale −$75,268 | 430,625 | Yes | Form 4 |
| Barrow RobertChief Executive Officer | Sep 25, 2025 | Sep 26, 2025 | S | 25,797 | $9.77 | Sale −$252,037 | 804,268 | Yes | Form 4 |
| Sullivan MarkChief Legal Officer | Sep 25, 2025 | Sep 26, 2025 | S | 11,278 | $9.77 | Sale −$110,186 | 293,852 | Yes | Form 4 |
| Barrow RobertChief Executive Officer | Jun 25, 2025 | Jun 26, 2025 | S | 26,491 | $6.80 | Sale −$180,139 | 830,065 | Yes | Form 4 |
| Karlin DanielChief Medical Officer | Jun 25, 2025 | Jun 26, 2025 | S | 7,848 | $6.80 | Sale −$53,366 | 438,329 | Yes | Form 4 |
| Sullivan MarkChief Legal Officer | Jun 25, 2025 | Jun 26, 2025 | S | 11,491 | $6.80 | Sale −$78,139 | 305,130 | Yes | Form 4 |
| Gryska David W | Jun 12, 2025 | Jun 16, 2025 | A · derivative | 75,187 | $7.30 | $548,865 | 75,187 | No | Form 4 |
| Crystal Roger | Jun 12, 2025 | Jun 16, 2025 | A · derivative | 75,187 | $7.30 | $548,865 | 75,187 | No | Form 4 |
| Bruhn Suzanne Louise | Jun 12, 2025 | Jun 16, 2025 | A · derivative | 75,187 | $7.30 | $548,865 | 75,187 | No | Form 4 |
| Vallone Carol A | Jun 12, 2025 | Jun 16, 2025 | A · derivative | 75,187 | $7.30 | $548,865 | 75,187 | No | Form 4 |
| Krebs Andreas | Jun 12, 2025 | Jun 16, 2025 | A · derivative | 75,187 | $7.30 | $548,865 | 75,187 | No | Form 4 |
| Roberts BrandiChief Financial Officer | Jun 2, 2025 | Jun 2, 2025 | A · derivative | 500,000 | $7.26 | $3,630,000 | 500,000 | No | Form 4 |
| Liao CarrieChief Accounting Officer | Mar 25, 2025 | Mar 26, 2025 | S | 2,347 | $6.74 | Sale −$15,819 | 144,923 | Yes | Form 4 |
| Sullivan MarkChief Legal Officer | Mar 25, 2025 | Mar 26, 2025 | S | 6,576 | $6.74 | Sale −$44,322 | 316,621 | Yes | Form 4 |
| Karlin DanielChief Medical Officer | Mar 25, 2025 | Mar 26, 2025 | S | 6,836 | $6.74 | Sale −$46,075 | 446,177 | Yes | Form 4 |
| Barrow RobertChief Executive Officer | Mar 25, 2025 | Mar 26, 2025 | S | 21,208 | $6.74 | Sale −$142,942 | 856,556 | Yes | Form 4 |
| Wiley Matthew T.Chief Commercial Officer | Mar 17, 2025 | Mar 18, 2025 | A · derivative | 350,000 | $6.35 | $2,222,500 | 350,000 | No | Form 4 |
| Liao CarrieChief Accounting Officer | Mar 12, 2025 | Mar 13, 2025 | A | 50,000 | $0.00 | $0 | 142,270 | No | Form 4 |
| Sullivan MarkChief Legal Officer | Mar 12, 2025 | Mar 13, 2025 | A | 150,000 | $0.00 | $0 | 323,197 | No | Form 4 |
| Karlin DanielChief Medical Officer | Mar 12, 2025 | Mar 13, 2025 | A | 115,000 | $0.00 | $0 | 453,013 | No | Form 4 |
| Barrow RobertChief Executive Officer | Mar 12, 2025 | Mar 13, 2025 | A | 350,000 | $0.00 | $0 | 877,764 | No | Form 4 |
| Sullivan MarkChief Legal Officer | Dec 26, 2024 | Dec 27, 2024 | S | 4,519 | $7.43 | Sale −$33,576 | 173,197 | Yes | Form 4 |
| Karlin DanChief Medical Officer | Dec 26, 2024 | Dec 27, 2024 | S | 6,643 | $7.43 | Sale −$49,357 | 338,013 | Yes | Form 4 |
| Liao CarrieChief Accounting Officer | Dec 26, 2024 | Dec 27, 2024 | S | 2,273 | $7.43 | Sale −$16,888 | 97,270 | Yes | Form 4 |
| Barrow RobertChief Executive Officer | Dec 26, 2024 | Dec 27, 2024 | S | 19,106 | $7.43 | Sale −$141,958 | 526,666 | Yes | Form 4 |
| Gryska David W | Dec 5, 2024 | Dec 5, 2024 | P | 2,500 | $7.17 | Purchase +$17,925 | 19,851 | No | Form 4 |
| Sullivan MarkChief Legal Officer | Sep 25, 2024 | Sep 25, 2024 | S | 4,430 | $5.98 | Sale −$26,491 | 177,716 | Yes | Form 4 |
| Karlin DanChief Medical Officer | Sep 25, 2024 | Sep 25, 2024 | S | 6,871 | $5.98 | Sale −$41,089 | 344,656 | Yes | Form 4 |
| Barrow RobertChief Executive Officer | Sep 25, 2024 | Sep 25, 2024 | S | 19,771 | $5.98 | Sale −$118,231 | 545,772 | Yes | Form 4 |
| Liao CarrieChief Accounting Officer | Sep 25, 2024 | Sep 25, 2024 | S | 2,352 | $5.98 | Sale −$14,065 | 99,543 | Yes | Form 4 |
| Gryska David W | Aug 23, 2024 | Aug 26, 2024 | P | 3,500 | $5.98 | Purchase +$20,930 | 17,351 | No | Form 4 |
| Halperin Wernli MiriExecutive President | Aug 21, 2024 | Aug 22, 2024 | M | 50,000 | $3.70 | $185,000 | 235,000 | No | Form 4 |
| Halperin Wernli MiriExecutive President | Aug 21, 2024 | Aug 22, 2024 | F | 32,595 | $6.17 | $201,111 | 202,405 | No | Form 4 |
| Halperin Wernli MiriExecutive President | Aug 21, 2024 | Aug 22, 2024 | M · derivative | 50,000 | $3.70 | $185,000 | not reported | No | Form 4 |
| Barrow RobertChief Executive Officer | Aug 20, 2024 | Aug 20, 2024 | P | 500 | $6.12 | Purchase +$3,060 | 565,543 | No | Form 4 |
| Barrow RobertChief Executive Officer | Aug 19, 2024 | Aug 20, 2024 | P | 500 | $6.31 | Purchase +$3,155 | 565,043 | No | Form 4 |
| Barrow RobertChief Executive Officer | Jun 25, 2024 | Jun 25, 2024 | S | 15,659 | $7.22 | Sale −$113,058 | 564,543 | Yes | Form 4 |
| Karlin DanChief Medical Officer | Jun 25, 2024 | Jun 25, 2024 | S | 6,925 | $7.22 | Sale −$49,999 | 351,527 | Yes | Form 4 |
| Sullivan MarkChief Legal Officer | Jun 25, 2024 | Jun 25, 2024 | S | 17,854 | $7.22 | Sale −$128,906 | 182,146 | Yes | Form 4 |
| Krebs Andreas | Jun 10, 2024 | Jun 12, 2024 | A · derivative | 16,506 | $7.25 | $119,669 | 16,506 | No | Form 4 |
| Bruhn Suzanne Louise | Jun 10, 2024 | Jun 12, 2024 | A · derivative | 16,506 | $7.25 | $119,669 | 16,506 | No | Form 4 |
| Crystal Roger | Jun 10, 2024 | Jun 12, 2024 | A · derivative | 16,506 | $7.25 | $119,669 | 16,506 | No | Form 4 |
| Gryska David W | Jun 10, 2024 | Jun 12, 2024 | A · derivative | 16,506 | $7.25 | $119,669 | 16,506 | No | Form 4 |
| Vallone Carol A | Jun 10, 2024 | Jun 12, 2024 | A · derivative | 16,506 | $7.25 | $119,669 | 16,506 | No | Form 4 |
| Barrow RobertChief Executive Officer | Mar 25, 2024 | Mar 26, 2024 | S | 16,519 | $9.50 | Sale −$156,931 | 580,202 | Yes | Form 4 |
| Karlin DanChief Medical Officer | Mar 25, 2024 | Mar 26, 2024 | S | 6,578 | $9.50 | Sale −$62,491 | 358,452 | Yes | Form 4 |
| Greenway Schond L.Chief Financial Officer | Mar 25, 2024 | Mar 26, 2024 | F | 5,560 | $9.78 | $54,377 | 211,057 | No | Form 4 |
| Karlin DanChief Medical Officer | Feb 27, 2024 | Feb 29, 2024 | A · derivative | 150,000 | $4.98 | $747,000 | 150,000 | No | Form 4 |
| Sullivan MarkChief Legal Officer | Feb 27, 2024 | Feb 29, 2024 | A · derivative | 125,000 | $4.98 | $622,500 | 125,000 | No | Form 4 |
| Barrow RobertChief Executive Officer | Feb 27, 2024 | Feb 29, 2024 | A · derivative | 400,000 | $4.98 | $1,992,000 | 400,000 | No | Form 4 |
| Liao CarrieChief Accounting Officer | Feb 27, 2024 | Feb 29, 2024 | A · derivative | 100,000 | $4.98 | $498,000 | 100,000 | No | Form 4 |
| Greenway Schond L.Chief Financial Officer | Feb 27, 2024 | Feb 29, 2024 | A · derivative | 150,000 | $4.98 | $747,000 | 150,000 | No | Form 4 |
| Wernli Miri HalperinExecutive President | Feb 27, 2024 | Feb 29, 2024 | A · derivative | 125,000 | $4.98 | $622,500 | 125,000 | No | Form 4 |
| Greenway Schond L.Chief Financial Officer | Dec 26, 2023 | Dec 26, 2023 | S | 5,652 | $3.63 | Sale −$20,517 | 216,617 | No | Form 4 |
| Barrow RobertChief Executive Officer | Dec 26, 2023 | Dec 26, 2023 | S | 13,237 | $3.63 | Sale −$48,050 | 596,721 | No | Form 4 |
| Karlin DanChief Medical Officer | Dec 26, 2023 | Dec 26, 2023 | S | 6,774 | $3.63 | Sale −$24,590 | 365,030 | No | Form 4 |