DNTHDianthus Therapeutics, Inc. /DE/
- Market cap
- $4.20B
- as of 2026-10-23
- Latest close
- $76.78
- as of 2026-10-23
- Sector
- Healthcare
- as of 2026-10-24
- Industry
- Biotechnology
- as of 2026-10-24
Cluster
No cluster in the last 90 days under the default rule (14d · ≥2 insiders · all roles).
Form 4 historysince 2023-10-03
| Insider | Traded | Filed | Type | Shares | Price | Value | Owned after | 10b5-1 plan | Filing |
|---|---|---|---|---|---|---|---|---|---|
| Carr EdwardCHIEF ACCOUNTING OFFICER | Sep 17 | Sep 18 | M | 20,000 | $17.88 | $357,600 | 20,000 | Yes | Form 4 |
| Carr EdwardCHIEF ACCOUNTING OFFICER | Sep 17 | Sep 18 | S | 7,928 | $100.43 | Sale −$796,209 | 12,072 | Yes | Form 4 |
| Carr EdwardCHIEF ACCOUNTING OFFICER | Sep 17 | Sep 18 | S | 6,771 | $101.37 | Sale −$686,376 | 5,301 | Yes | Form 4 |
| Carr EdwardCHIEF ACCOUNTING OFFICER | Sep 17 | Sep 18 | S | 3,501 | $102.39 | Sale −$358,467 | 1,800 | Yes | Form 4 |
| Carr EdwardCHIEF ACCOUNTING OFFICER | Sep 17 | Sep 18 | S | 1,100 | $103.20 | Sale −$113,520 | 700 | Yes | Form 4 |
| Carr EdwardCHIEF ACCOUNTING OFFICER | Sep 17 | Sep 18 | S | 700 | $104.39 | Sale −$73,073 | not reported | Yes | Form 4 |
| Carr EdwardCHIEF ACCOUNTING OFFICER | Sep 17 | Sep 18 | M · derivative | 20,000 | $17.88 | $357,600 | 43,818 | Yes | Form 4 |
| Randhawa SimratEVP, Head of R&D | Sep 1 | Sep 3 | M | 7,500 | $17.88 | $134,100 | 11,500 | Yes | Form 4 |
| Randhawa SimratEVP, Head of R&D | Sep 1 | Sep 3 | M | 6,249 | $21.77 | $136,041 | 17,749 | Yes | Form 4 |
| Randhawa SimratEVP, Head of R&D | Sep 1 | Sep 3 | M | 9,375 | $22.07 | $206,906 | 27,124 | Yes | Form 4 |
| Randhawa SimratEVP, Head of R&D | Sep 1 | Sep 3 | S | 2,600 | $105.19 | Sale −$273,494 | 24,524 | Yes | Form 4 |
| Randhawa SimratEVP, Head of R&D | Sep 1 | Sep 3 | S | 7,215 | $106.25 | Sale −$766,594 | 17,309 | Yes | Form 4 |
| Randhawa SimratEVP, Head of R&D | Sep 1 | Sep 3 | S | 13,309 | $106.74 | Sale −$1,420,603 | 4,000 | Yes | Form 4 |
| Randhawa SimratEVP, Head of R&D | Sep 1 | Sep 3 | M · derivative | 7,500 | $17.88 | $134,100 | 56,776 | Yes | Form 4 |
| Randhawa SimratEVP, Head of R&D | Sep 1 | Sep 3 | M · derivative | 6,249 | $21.77 | $136,041 | 41,676 | Yes | Form 4 |
| Randhawa SimratEVP, Head of R&D | Sep 1 | Sep 3 | M · derivative | 9,375 | $22.07 | $206,906 | 87,500 | Yes | Form 4 |
| Read Simon | Aug 19 | Aug 19 | M | 2,778 | $18.36 | $51,004 | 2,778 | Yes | Form 4 |
| Read Simon | Aug 19 | Aug 19 | S | 2,778 | $117.55 | Sale −$326,554 | not reported | Yes | Form 4 |
| Read Simon | Aug 19 | Aug 19 | M · derivative | 2,778 | $18.36 | $51,004 | 19,445 | Yes | Form 4 |
| Veness Adam MSVP, General Counsel and Sec. | Aug 13 | Aug 14 | M | 15,000 | $18.17 | $272,550 | 15,000 | No | Form 4 |
| Veness Adam MSVP, General Counsel and Sec. | Aug 13 | Aug 14 | M · derivative | 15,000 | $18.17 | $272,550 | 73,240 | No | Form 4 |
| Read Simon | Aug 10 | Aug 11 | M | 2,777 | $18.36 | $50,986 | 2,777 | Yes | Form 4 |
| Read Simon | Aug 10 | Aug 11 | S | 70 | $107.11 | Sale −$7,498 | 2,707 | Yes | Form 4 |
| Read Simon | Aug 10 | Aug 11 | S | 737 | $108.17 | Sale −$79,721 | 1,970 | Yes | Form 4 |
| Read Simon | Aug 10 | Aug 11 | S | 831 | $108.95 | Sale −$90,537 | 1,139 | Yes | Form 4 |
| Read Simon | Aug 10 | Aug 11 | S | 272 | $109.96 | Sale −$29,909 | 867 | Yes | Form 4 |
| Read Simon | Aug 10 | Aug 11 | S | 470 | $111.05 | Sale −$52,194 | 397 | Yes | Form 4 |
| Read Simon | Aug 10 | Aug 11 | S | 397 | $111.77 | Sale −$44,373 | not reported | Yes | Form 4 |
| Read Simon | Aug 10 | Aug 11 | M · derivative | 2,777 | $18.36 | $50,986 | 22,223 | Yes | Form 4 |
| Veness Adam MSVP, General Counsel and Sec. | Aug 10 | Aug 11 | M | 16,167 | $17.88 | $289,066 | 16,167 | Yes | Form 4 |
| Veness Adam MSVP, General Counsel and Sec. | Aug 10 | Aug 11 | S | 16,167 | $110.38 | Sale −$1,784,513 | not reported | Yes | Form 4 |
| Veness Adam MSVP, General Counsel and Sec. | Aug 10 | Aug 11 | M · derivative | 16,167 | $17.88 | $289,066 | 60,000 | Yes | Form 4 |
| McGeorge Anne | Aug 10 | Aug 11 | M | 1,250 | $19.36 | $24,200 | 1,250 | Yes | Form 4 |
| McGeorge Anne | Aug 10 | Aug 11 | M | 6,500 | $11.20 | $72,800 | 7,750 | Yes | Form 4 |
| McGeorge Anne | Aug 10 | Aug 11 | S | 1,450 | $107.58 | Sale −$155,991 | 6,300 | Yes | Form 4 |
| McGeorge Anne | Aug 10 | Aug 11 | S | 2,800 | $108.38 | Sale −$303,464 | 3,500 | Yes | Form 4 |
| McGeorge Anne | Aug 10 | Aug 11 | S | 1,800 | $109.30 | Sale −$196,740 | 1,700 | Yes | Form 4 |
| McGeorge Anne | Aug 10 | Aug 11 | S | 1,000 | $110.64 | Sale −$110,640 | 700 | Yes | Form 4 |
| McGeorge Anne | Aug 10 | Aug 11 | S | 700 | $111.41 | Sale −$77,987 | not reported | Yes | Form 4 |
| McGeorge Anne | Aug 10 | Aug 11 | M · derivative | 1,250 | $19.36 | $24,200 | not reported | Yes | Form 4 |
| McGeorge Anne | Aug 10 | Aug 11 | M · derivative | 6,500 | $11.20 | $72,800 | not reported | Yes | Form 4 |
| Veness Adam MSVP, General Counsel and Sec. | Aug 7 | Aug 11 | M | 3,833 | $17.88 | $68,534 | 3,833 | Yes | Form 4 |
| Veness Adam MSVP, General Counsel and Sec. | Aug 7 | Aug 11 | S | 3,217 | $110.61 | Sale −$355,832 | 616 | Yes | Form 4 |
| Veness Adam MSVP, General Counsel and Sec. | Aug 7 | Aug 11 | S | 616 | $111.18 | Sale −$68,487 | not reported | Yes | Form 4 |
| Veness Adam MSVP, General Counsel and Sec. | Aug 7 | Aug 11 | M · derivative | 3,833 | $17.88 | $68,534 | 76,167 | Yes | Form 4 |
| Garcia MarinoCEO AND PRESIDENT | Aug 7 | Aug 7 | M | 40,000 | $8.44 | $337,600 | 105,292 | Yes | Form 4 |
| Garcia MarinoCEO AND PRESIDENT | Aug 7 | Aug 7 | M | 126,000 | $8.44 | $1,063,440 | 231,292 | Yes | Form 4 |
| Garcia MarinoCEO AND PRESIDENT | Aug 7 | Aug 7 | S | 10,384 | $107.49 | Sale −$1,116,176 | 220,908 | Yes | Form 4 |
| Garcia MarinoCEO AND PRESIDENT | Aug 7 | Aug 7 | S | 23,907 | $108.05 | Sale −$2,583,151 | 197,001 | Yes | Form 4 |
| Garcia MarinoCEO AND PRESIDENT | Aug 7 | Aug 7 | S | 2,373 | $109.10 | Sale −$258,894 | 194,628 | Yes | Form 4 |
| Garcia MarinoCEO AND PRESIDENT | Aug 7 | Aug 7 | S | 2,536 | $110.02 | Sale −$279,011 | 192,092 | Yes | Form 4 |
| Garcia MarinoCEO AND PRESIDENT | Aug 7 | Aug 7 | S | 800 | $110.76 | Sale −$88,608 | 191,292 | Yes | Form 4 |
| Garcia MarinoCEO AND PRESIDENT | Aug 7 | Aug 7 | S | 104,091 | $107.96 | Sale −$11,237,664 | 87,102 | Yes | Form 4 |
| Garcia MarinoCEO AND PRESIDENT | Aug 7 | Aug 7 | S | 21,909 | $108.72 | Sale −$2,381,946 | 65,292 | Yes | Form 4 |
| Garcia MarinoCEO AND PRESIDENT | Aug 7 | Aug 7 | M · derivative | 40,000 | $8.44 | $337,600 | 286,004 | Yes | Form 4 |
| Garcia MarinoCEO AND PRESIDENT | Aug 7 | Aug 7 | M · derivative | 126,000 | $8.44 | $1,063,440 | 160,004 | Yes | Form 4 |
| Savitz RyanEVP, CFO & CBO | Jul 9 | Jul 13 | M | 31,249 | $21.77 | $680,291 | 31,249 | Yes | Form 4 |
| Savitz RyanEVP, CFO & CBO | Jul 9 | Jul 13 | S | 10,354 | $100.22 | Sale −$1,037,678 | 20,895 | Yes | Form 4 |
| Savitz RyanEVP, CFO & CBO | Jul 9 | Jul 13 | S | 15,329 | $101.24 | Sale −$1,551,908 | 5,566 | Yes | Form 4 |
| Savitz RyanEVP, CFO & CBO | Jul 9 | Jul 13 | S | 5,566 | $101.97 | Sale −$567,565 | not reported | Yes | Form 4 |
| Savitz RyanEVP, CFO & CBO | Jul 9 | Jul 13 | M · derivative | 31,249 | $21.77 | $680,291 | 68,751 | Yes | Form 4 |
| Veness Adam MSVP, General Counsel and Sec. | Jun 17 | Jun 18 | M | 30,000 | $17.88 | $536,400 | 30,000 | Yes | Form 4 |
| Veness Adam MSVP, General Counsel and Sec. | Jun 17 | Jun 18 | S | 16,771 | $80.34 | Sale −$1,347,382 | 13,229 | Yes | Form 4 |
| Veness Adam MSVP, General Counsel and Sec. | Jun 17 | Jun 18 | S | 13,229 | $81.38 | Sale −$1,076,576 | not reported | Yes | Form 4 |
| Veness Adam MSVP, General Counsel and Sec. | Jun 17 | Jun 18 | M · derivative | 30,000 | $17.88 | $536,400 | 80,000 | Yes | Form 4 |
| Randhawa SimratEVP, Head of R&D | Jun 1 | Jun 2 | M | 3,998 | $8.44 | $33,743 | 7,998 | Yes | Form 4 |
| Randhawa SimratEVP, Head of R&D | Jun 1 | Jun 2 | M | 6,908 | $17.88 | $123,515 | 14,906 | Yes | Form 4 |
| Randhawa SimratEVP, Head of R&D | Jun 1 | Jun 2 | M | 6,249 | $21.77 | $136,041 | 21,155 | Yes | Form 4 |
| Randhawa SimratEVP, Head of R&D | Jun 1 | Jun 2 | M | 9,375 | $22.07 | $206,906 | 30,530 | Yes | Form 4 |
| Randhawa SimratEVP, Head of R&D | Jun 1 | Jun 2 | S | 5,428 | $89.72 | Sale −$487,000 | 25,102 | Yes | Form 4 |
| Randhawa SimratEVP, Head of R&D | Jun 1 | Jun 2 | S | 16,943 | $90.72 | Sale −$1,537,069 | 8,159 | Yes | Form 4 |
| Randhawa SimratEVP, Head of R&D | Jun 1 | Jun 2 | S | 4,159 | $91.37 | Sale −$380,008 | 4,000 | Yes | Form 4 |
| Randhawa SimratEVP, Head of R&D | Jun 1 | Jun 2 | M · derivative | 3,998 | $8.44 | $33,743 | not reported | Yes | Form 4 |
| Randhawa SimratEVP, Head of R&D | Jun 1 | Jun 2 | M · derivative | 6,908 | $17.88 | $123,515 | 64,276 | Yes | Form 4 |
| Randhawa SimratEVP, Head of R&D | Jun 1 | Jun 2 | M · derivative | 6,249 | $21.77 | $136,041 | 47,925 | Yes | Form 4 |
| Randhawa SimratEVP, Head of R&D | Jun 1 | Jun 2 | M · derivative | 9,375 | $22.07 | $206,906 | 96,875 | Yes | Form 4 |
| Kango Sujay | May 21 | May 22 | A · derivative | 6,090 | $89.63 | $545,847 | 6,090 | No | Form 4 |
| Lawton Alison Frances | May 21 | May 22 | A · derivative | 6,090 | $89.63 | $545,847 | 6,090 | No | Form 4 |
| Romano Steven J. | May 21 | May 22 | A · derivative | 6,090 | $89.63 | $545,847 | 6,090 | No | Form 4 |
| Read Simon | May 21 | May 22 | A · derivative | 6,090 | $89.63 | $545,847 | 6,090 | No | Form 4 |
| Soteropoulos Paula | May 21 | May 22 | A · derivative | 6,090 | $89.63 | $545,847 | 6,090 | No | Form 4 |
| Violin Jonathan | May 21 | May 22 | A · derivative | 6,090 | $89.63 | $545,847 | 6,090 | No | Form 4 |
| McGeorge Anne | May 21 | May 22 | A · derivative | 6,090 | $89.63 | $545,847 | 6,090 | No | Form 4 |
| Soteropoulos Paula | May 8 | May 11 | M | 599 | $8.44 | $5,056 | 599 | Yes | Form 4 |
| Soteropoulos Paula | May 8 | May 11 | S | 599 | $85.47 | Sale −$51,197 | not reported | Yes | Form 4 |
| Soteropoulos Paula | May 8 | May 11 | M · derivative | 599 | $8.44 | $5,056 | not reported | Yes | Form 4 |
| Savitz RyanEVP, CFO & CBO | Apr 9 | Apr 10 | M | 8,224 | $17.88 | $147,045 | 8,224 | Yes | Form 4 |
| Savitz RyanEVP, CFO & CBO | Apr 9 | Apr 10 | S | 8,224 | $89.84 | Sale −$738,844 | not reported | Yes | Form 4 |
| Savitz RyanEVP, CFO & CBO | Apr 9 | Apr 10 | M · derivative | 8,224 | $17.88 | $147,045 | 71,776 | Yes | Form 4 |
| Soteropoulos Paula | Mar 31 | Apr 1 | M | 599 | $8.44 | $5,056 | 599 | Yes | Form 4 |
| Soteropoulos Paula | Mar 31 | Apr 1 | S | 599 | $80.11 | Sale −$47,986 | not reported | Yes | Form 4 |
| Soteropoulos Paula | Mar 31 | Apr 1 | M · derivative | 599 | $8.44 | $5,056 | 599 | Yes | Form 4 |
| Savitz RyanEVP, CFO & CBO | Mar 31 | Apr 1 | M | 74,367 | $8.44 | $627,657 | 74,367 | Yes | Form 4 |
| Savitz RyanEVP, CFO & CBO | Mar 31 | Apr 1 | M | 40,000 | $17.88 | $715,200 | 114,367 | Yes | Form 4 |
| Savitz RyanEVP, CFO & CBO | Mar 31 | Apr 1 | S | 1,390 | $78.33 | Sale −$108,879 | 112,977 | Yes | Form 4 |
| Savitz RyanEVP, CFO & CBO | Mar 31 | Apr 1 | S | 21,825 | $78.86 | Sale −$1,721,120 | 91,152 | Yes | Form 4 |
| Savitz RyanEVP, CFO & CBO | Mar 31 | Apr 1 | S | 1,485 | $80.25 | Sale −$119,171 | 89,667 | Yes | Form 4 |
| Savitz RyanEVP, CFO & CBO | Mar 31 | Apr 1 | S | 800 | $81.36 | Sale −$65,088 | 88,867 | Yes | Form 4 |
| Savitz RyanEVP, CFO & CBO | Mar 31 | Apr 1 | S | 2,366 | $82.84 | Sale −$195,999 | 86,501 | Yes | Form 4 |
| Savitz RyanEVP, CFO & CBO | Mar 31 | Apr 1 | S | 59,800 | $83.90 | Sale −$5,017,220 | 26,701 | Yes | Form 4 |
| Savitz RyanEVP, CFO & CBO | Mar 31 | Apr 1 | S | 19,469 | $84.57 | Sale −$1,646,493 | 7,232 | Yes | Form 4 |
| Savitz RyanEVP, CFO & CBO | Mar 31 | Apr 1 | S | 7,232 | $85.54 | Sale −$618,625 | not reported | Yes | Form 4 |
| Savitz RyanEVP, CFO & CBO | Mar 31 | Apr 1 | M · derivative | 74,367 | $8.44 | $627,657 | 10,399 | Yes | Form 4 |
| Savitz RyanEVP, CFO & CBO | Mar 31 | Apr 1 | M · derivative | 40,000 | $17.88 | $715,200 | 80,000 | Yes | Form 4 |
| Soteropoulos Paula | Mar 24 | Mar 26 | M | 27,594 | $8.44 | $232,893 | 27,594 | Yes | Form 4 |
| Soteropoulos Paula | Mar 24 | Mar 26 | S | 27,594 | $78.05 | Sale −$2,153,712 | not reported | Yes | Form 4 |
| Soteropoulos Paula | Mar 24 | Mar 26 | M · derivative | 27,594 | $8.44 | $232,893 | 1,198 | Yes | Form 4 |
| Garcia MarinoCEO AND PRESIDENT | Mar 16 | Mar 17 | M | 59,700 | $6.70 | $399,990 | 59,700 | No | Form 4 |
| Garcia MarinoCEO AND PRESIDENT | Mar 16 | Mar 17 | M | 5,592 | $17.88 | $99,985 | 65,292 | No | Form 4 |
| Garcia MarinoCEO AND PRESIDENT | Mar 16 | Mar 17 | M · derivative | 59,700 | $6.70 | $399,990 | 41 | No | Form 4 |
| Garcia MarinoCEO AND PRESIDENT | Mar 16 | Mar 17 | M · derivative | 5,592 | $17.88 | $99,985 | 269,408 | No | Form 4 |
| Carr EdwardCHIEF ACCOUNTING OFFICER | Mar 12 | Mar 13 | M | 16,182 | $17.88 | $289,334 | 16,182 | Yes | Form 4 |
| Carr EdwardCHIEF ACCOUNTING OFFICER | Mar 12 | Mar 13 | M | 17,500 | $22.07 | $386,225 | 33,682 | Yes | Form 4 |
| Carr EdwardCHIEF ACCOUNTING OFFICER | Mar 12 | Mar 13 | M | 10,000 | $21.77 | $217,700 | 43,682 | Yes | Form 4 |
| Carr EdwardCHIEF ACCOUNTING OFFICER | Mar 12 | Mar 13 | S | 15,852 | $80.71 | Sale −$1,279,415 | 27,830 | Yes | Form 4 |
| Carr EdwardCHIEF ACCOUNTING OFFICER | Mar 12 | Mar 13 | S | 23,465 | $81.75 | Sale −$1,918,264 | 4,365 | Yes | Form 4 |
| Carr EdwardCHIEF ACCOUNTING OFFICER | Mar 12 | Mar 13 | S | 3,865 | $82.66 | Sale −$319,481 | 500 | Yes | Form 4 |
| Carr EdwardCHIEF ACCOUNTING OFFICER | Mar 12 | Mar 13 | S | 200 | $83.38 | Sale −$16,676 | 300 | Yes | Form 4 |
| Carr EdwardCHIEF ACCOUNTING OFFICER | Mar 12 | Mar 13 | S | 300 | $85.53 | Sale −$25,659 | not reported | Yes | Form 4 |
| Carr EdwardCHIEF ACCOUNTING OFFICER | Mar 12 | Mar 13 | M · derivative | 16,182 | $17.88 | $289,334 | 63,818 | Yes | Form 4 |
| Carr EdwardCHIEF ACCOUNTING OFFICER | Mar 12 | Mar 13 | M · derivative | 17,500 | $22.07 | $386,225 | 42,500 | Yes | Form 4 |
| Carr EdwardCHIEF ACCOUNTING OFFICER | Mar 12 | Mar 13 | M · derivative | 10,000 | $21.77 | $217,700 | 50,000 | Yes | Form 4 |
| Garcia MarinoCEO AND PRESIDENT | Mar 12 | Mar 13 | M | 122,918 | $6.70 | $823,551 | 122,918 | Yes | Form 4 |
| Garcia MarinoCEO AND PRESIDENT | Mar 12 | Mar 13 | S | 43,505 | $80.69 | Sale −$3,510,418 | 79,413 | Yes | Form 4 |
| Garcia MarinoCEO AND PRESIDENT | Mar 12 | Mar 13 | S | 65,517 | $81.74 | Sale −$5,355,360 | 13,896 | Yes | Form 4 |
| Garcia MarinoCEO AND PRESIDENT | Mar 12 | Mar 13 | S | 12,796 | $82.60 | Sale −$1,056,950 | 1,100 | Yes | Form 4 |
| Garcia MarinoCEO AND PRESIDENT | Mar 12 | Mar 13 | S | 200 | $83.38 | Sale −$16,676 | 900 | Yes | Form 4 |
| Garcia MarinoCEO AND PRESIDENT | Mar 12 | Mar 13 | S | 900 | $85.53 | Sale −$76,977 | not reported | Yes | Form 4 |
| Garcia MarinoCEO AND PRESIDENT | Mar 12 | Mar 13 | M · derivative | 122,918 | $6.70 | $823,551 | 59,741 | Yes | Form 4 |
| Randhawa SimratEVP, Head of R&D | Mar 12 | Mar 13 | M | 7,998 | $8.44 | $67,503 | 7,998 | Yes | Form 4 |
| Randhawa SimratEVP, Head of R&D | Mar 12 | Mar 13 | M | 5,000 | $17.88 | $89,400 | 12,998 | Yes | Form 4 |
| Randhawa SimratEVP, Head of R&D | Mar 12 | Mar 13 | M | 8,332 | $21.77 | $181,388 | 21,330 | Yes | Form 4 |
| Randhawa SimratEVP, Head of R&D | Mar 12 | Mar 13 | M | 12,500 | $22.07 | $275,875 | 33,830 | Yes | Form 4 |
| Randhawa SimratEVP, Head of R&D | Mar 12 | Mar 13 | S | 33,830 | $81.48 | Sale −$2,756,468 | not reported | Yes | Form 4 |
| Randhawa SimratEVP, Head of R&D | Mar 12 | Mar 13 | M · derivative | 7,998 | $8.44 | $67,503 | 3,998 | Yes | Form 4 |
| Randhawa SimratEVP, Head of R&D | Mar 12 | Mar 13 | M · derivative | 5,000 | $17.88 | $89,400 | 71,184 | Yes | Form 4 |
| Randhawa SimratEVP, Head of R&D | Mar 12 | Mar 13 | M · derivative | 8,332 | $21.77 | $181,388 | 54,174 | Yes | Form 4 |
| Randhawa SimratEVP, Head of R&D | Mar 12 | Mar 13 | M · derivative | 12,500 | $22.07 | $275,875 | 106,250 | Yes | Form 4 |
| Carr EdwardCHIEF ACCOUNTING OFFICER | Feb 3 | Feb 4 | A · derivative | 55,000 | $52.46 | $2,885,300 | 55,000 | No | Form 4 |
| Garcia MarinoCEO AND PRESIDENT | Feb 3 | Feb 4 | A · derivative | 355,000 | $52.46 | $18,623,300 | 355,000 | No | Form 4 |
| Veness Adam MSVP, General Counsel and Sec. | Feb 3 | Feb 4 | A · derivative | 100,000 | $52.46 | $5,246,000 | 100,000 | No | Form 4 |
| Randhawa SimratEVP, Head of R&D | Feb 3 | Feb 4 | A · derivative | 150,000 | $52.46 | $7,869,000 | 150,000 | No | Form 4 |
| Savitz RyanEVP, CFO & CBO | Feb 3 | Feb 4 | A · derivative | 150,000 | $52.46 | $7,869,000 | 150,000 | No | Form 4 |
| Savitz RyanCFO & CBO | Dec 4, 2025 | Dec 5, 2025 | M | 20,000 | $8.44 | $168,800 | 20,000 | Yes | Form 4 |
| Savitz RyanCFO & CBO | Dec 4, 2025 | Dec 5, 2025 | S | 20,000 | $45.18 | Sale −$903,600 | not reported | Yes | Form 4 |
| Savitz RyanCFO & CBO | Dec 4, 2025 | Dec 5, 2025 | M · derivative | 20,000 | $8.44 | $168,800 | 84,766 | Yes | Form 4 |
| Randhawa SimratEVP, Head of R&D | Nov 14, 2025 | Nov 14, 2025 | M | 40,287 | $17.88 | $720,332 | 44,287 | Yes | Form 4 |
| Randhawa SimratEVP, Head of R&D | Nov 14, 2025 | Nov 14, 2025 | M | 37,494 | $21.77 | $816,244 | 81,781 | Yes | Form 4 |
| Randhawa SimratEVP, Head of R&D | Nov 14, 2025 | Nov 14, 2025 | M | 31,250 | $22.07 | $689,688 | 113,031 | Yes | Form 4 |
| Randhawa SimratEVP, Head of R&D | Nov 14, 2025 | Nov 14, 2025 | S | 109,031 | $38.14 | Sale −$4,158,442 | 4,000 | Yes | Form 4 |
| Randhawa SimratEVP, Head of R&D | Nov 14, 2025 | Nov 14, 2025 | M · derivative | 40,287 | $17.88 | $720,332 | 76,184 | Yes | Form 4 |
| Randhawa SimratEVP, Head of R&D | Nov 14, 2025 | Nov 14, 2025 | M · derivative | 37,494 | $21.77 | $816,244 | 62,506 | Yes | Form 4 |
| Randhawa SimratEVP, Head of R&D | Nov 14, 2025 | Nov 14, 2025 | M · derivative | 31,250 | $22.07 | $689,688 | 118,750 | Yes | Form 4 |
| Randhawa SimratEVP, Head of R&D | Nov 13, 2025 | Nov 14, 2025 | M | 83,978 | $8.44 | $708,774 | 87,978 | Yes | Form 4 |
| Randhawa SimratEVP, Head of R&D | Nov 13, 2025 | Nov 14, 2025 | M | 3,529 | $17.88 | $63,099 | 91,507 | Yes | Form 4 |
| Randhawa SimratEVP, Head of R&D | Nov 13, 2025 | Nov 14, 2025 | S | 26,166 | $35.80 | Sale −$936,743 | 65,341 | Yes | Form 4 |
| Randhawa SimratEVP, Head of R&D | Nov 13, 2025 | Nov 14, 2025 | S | 42,765 | $37.04 | Sale −$1,584,016 | 22,576 | Yes | Form 4 |
| Randhawa SimratEVP, Head of R&D | Nov 13, 2025 | Nov 14, 2025 | S | 18,576 | $37.72 | Sale −$700,687 | 4,000 | Yes | Form 4 |
| Randhawa SimratEVP, Head of R&D | Nov 13, 2025 | Nov 14, 2025 | M · derivative | 83,978 | $8.44 | $708,774 | 11,996 | Yes | Form 4 |
| Randhawa SimratEVP, Head of R&D | Nov 13, 2025 | Nov 14, 2025 | M · derivative | 3,529 | $17.88 | $63,099 | 116,471 | Yes | Form 4 |
| Garcia MarinoCEO AND PRESIDENT | Sep 30, 2025 | Oct 3, 2025 | A · derivative | 120,000 | $39.35 | $4,722,000 | 120,000 | No | Form 4 |
| Randhawa SimratCHIEF MEDICAL OFFICER | Sep 23, 2025 | Sep 25, 2025 | A · derivative | 60,000 | $37.87 | $2,272,200 | 60,000 | No | Form 4 |
| Savitz RyanCFO & CBO | Sep 23, 2025 | Sep 25, 2025 | A · derivative | 60,000 | $37.87 | $2,272,200 | 60,000 | No | Form 4 |
| Savitz RyanCFO & CBO | Sep 9, 2025 | Sep 11, 2025 | M | 20,000 | $8.44 | $168,800 | 20,000 | Yes | Form 4 |
| Savitz RyanCFO & CBO | Sep 9, 2025 | Sep 11, 2025 | S | 20,000 | $35.00 | Sale −$700,000 | not reported | Yes | Form 4 |
| Savitz RyanCFO & CBO | Sep 9, 2025 | Sep 11, 2025 | M · derivative | 20,000 | $8.44 | $168,800 | 104,766 | Yes | Form 4 |
| Read Simon | May 22, 2025 | May 22, 2025 | A · derivative | 25,000 | $18.36 | $459,000 | 25,000 | No | Form 4 |
| Lawton Alison Frances | May 22, 2025 | May 22, 2025 | A · derivative | 12,500 | $18.36 | $229,500 | 12,500 | No | Form 4 |
| McGeorge Anne | May 22, 2025 | May 22, 2025 | A · derivative | 12,500 | $18.36 | $229,500 | 12,500 | No | Form 4 |
| Romano Steven J. | May 22, 2025 | May 22, 2025 | A · derivative | 12,500 | $18.36 | $229,500 | 12,500 | No | Form 4 |
| Soteropoulos Paula | May 22, 2025 | May 22, 2025 | A · derivative | 12,500 | $18.36 | $229,500 | 12,500 | No | Form 4 |
| Violin Jonathan | May 22, 2025 | May 22, 2025 | A · derivative | 12,500 | $18.36 | $229,500 | 12,500 | No | Form 4 |
| Kango Sujay | Mar 4, 2025 | Mar 5, 2025 | A · derivative | 25,000 | $19.86 | $496,500 | 25,000 | No | Form 4 |
| Garcia MarinoCEO AND PRESIDENT | Feb 3, 2025 | Feb 4, 2025 | A · derivative | 340,000 | $22.07 | $7,503,800 | 340,000 | No | Form 4 |
| Savitz RyanCFO & CBO | Feb 3, 2025 | Feb 4, 2025 | A · derivative | 150,000 | $22.07 | $3,310,500 | 150,000 | No | Form 4 |
| Randhawa SimratCHIEF MEDICAL OFFICER | Feb 3, 2025 | Feb 4, 2025 | A · derivative | 150,000 | $22.07 | $3,310,500 | 150,000 | No | Form 4 |
| Veness Adam MSVP, General Counsel and Sec. | Feb 3, 2025 | Feb 4, 2025 | A · derivative | 100,000 | $22.07 | $2,207,000 | 100,000 | No | Form 4 |
| Carr EdwardCHIEF ACCOUNTING OFFICER | Feb 3, 2025 | Feb 4, 2025 | A · derivative | 60,000 | $22.07 | $1,324,200 | 60,000 | No | Form 4 |
| Kiselak Tomas | Sep 27, 2024 | Oct 1, 2024 | J | 62,146 | $0.00 | $0 | not reported | No | Form 4 |
| Romano Steven J. | Sep 16, 2024 | Sep 18, 2024 | A · derivative | 22,000 | $26.42 | $581,240 | 22,000 | No | Form 4 |
| Fairmount Funds Management LLC | May 23, 2024 | May 28, 2024 | A · derivative | 11,000 | $21.77 | $239,470 | 11,000 | No | Form 4 |
| Lawton Alison Frances | May 23, 2024 | May 28, 2024 | A · derivative | 11,000 | $21.77 | $239,470 | 11,000 | No | Form 4 |
| McGeorge Anne | May 23, 2024 | May 28, 2024 | A · derivative | 11,000 | $21.77 | $239,470 | 11,000 | No | Form 4 |
| Moulder Leon O Jr | May 23, 2024 | May 28, 2024 | A · derivative | 11,000 | $21.77 | $239,470 | 11,000 | No | Form 4 |
| Soteropoulos Paula | May 23, 2024 | May 28, 2024 | A · derivative | 11,000 | $21.77 | $239,470 | 11,000 | No | Form 4 |
| Violin Jonathan | May 23, 2024 | May 28, 2024 | A · derivative | 11,000 | $21.77 | $239,470 | 11,000 | No | Form 4 |
| Garcia MarinoCEO AND PRESIDENT | May 23, 2024 | May 28, 2024 | A · derivative | 243,000 | $21.77 | $5,290,110 | 243,000 | No | Form 4 |
| Savitz RyanCFO & CBO | May 23, 2024 | May 28, 2024 | A · derivative | 100,000 | $21.77 | $2,177,000 | 100,000 | No | Form 4 |
| Randhawa SimratCHIEF MEDICAL OFFICER | May 23, 2024 | May 28, 2024 | A · derivative | 100,000 | $21.77 | $2,177,000 | 100,000 | No | Form 4 |
| Veness Adam MSVP, General Counsel and Sec. | May 23, 2024 | May 28, 2024 | A · derivative | 75,000 | $21.77 | $1,632,750 | 75,000 | No | Form 4 |
| Carr EdwardCHIEF ACCOUNTING OFFICER | May 23, 2024 | May 28, 2024 | A · derivative | 60,000 | $21.77 | $1,306,200 | 60,000 | No | Form 4 |
| Kiselak Tomas | Apr 1, 2024 | Apr 1, 2024 | J | 58,857 | not reported | not reported | not reported | No | Form 4 |
| Kiselak Tomas | Apr 1, 2024 | Apr 1, 2024 | J | 58,857 | not reported | not reported | 2,700,691 | No | Form 4 |
| Garcia MarinoCEO AND PRESIDENT | Jan 24, 2024 | Jan 26, 2024 | A · derivative | 275,000 | $17.88 | $4,917,000 | 275,000 | No | Form 4 |
| Savitz RyanCHIEF FINANCIAL OFFICER | Jan 24, 2024 | Jan 26, 2024 | A · derivative | 120,000 | $17.88 | $2,145,600 | 120,000 | No | Form 4 |
| Randhawa SimratCHIEF MEDICAL OFFICER | Jan 24, 2024 | Jan 26, 2024 | A · derivative | 120,000 | $17.88 | $2,145,600 | 120,000 | No | Form 4 |
| Veness Adam MSVP, General Counsel and Sec. | Jan 24, 2024 | Jan 26, 2024 | A · derivative | 110,000 | $17.88 | $1,966,800 | 110,000 | No | Form 4 |
| Carr EdwardCHIEF ACCOUNTING OFFICER | Jan 24, 2024 | Jan 26, 2024 | A · derivative | 80,000 | $17.88 | $1,430,400 | 80,000 | No | Form 4 |
| Avidity Partners Management (GP) LLC | Jan 22, 2024 | Jan 24, 2024 | A | 1,500,000 | $12.00 | $18,000,000 | 2,717,554 | No | Form 4 |
| Avidity Partners Management (GP) LLC | Jan 22, 2024 | Jan 24, 2024 | A · derivative | 1,833,333 | $12.00 | $21,999,996 | 1,833,333 | No | Form 4 |
| Fairmount Funds Management LLC | Jan 22, 2024 | Jan 24, 2024 | A | 834,334 | $12.00 | $10,012,008 | 2,762,837 | No | Form 4 |
| Fairmount Funds Management LLC | Jan 22, 2024 | Jan 24, 2024 | A · derivative | 832,333 | $12.00 | $9,987,996 | 832,333 | No | Form 4 |
| Moulder Leon O Jr | Jan 22, 2024 | Jan 24, 2024 | A | 166,667 | $12.00 | $2,000,004 | 1,436,745 | No | Form 4 |
| Harwin Peter Evan | Sep 29, 2023 | Oct 3, 2023 | P | 24,670 | $13.63 | Purchase +$336,252 | 1,928,503 | No | Form 4 |