ELVNEnliven Therapeutics, Inc.
- Market cap
- $3.04B
- as of 2026-10-23
- Latest close
- $41.52
- as of 2026-10-23
- Sector
- Healthcare
- as of 2026-10-24
- Industry
- Biotechnology
- as of 2026-10-24
Cluster
No cluster in the last 90 days under the default rule (14d · ≥2 insiders · all roles).
Form 4 historysince 2023-10-03
Dashed line = amended filing (Form 4/A)
Showing the latest 500 of 572 transactions.
| Insider | Traded | Filed | Type | Shares | Price | Value | Owned after | 10b5-1 plan | Filing |
|---|---|---|---|---|---|---|---|---|---|
| Hohl BenjaminCHIEF FINANCIAL OFFICER | Oct 19 | Oct 21 | M | 6,018 | $14.85 | $89,367 | 44,018 | Yes | Form 4 |
| Hohl BenjaminCHIEF FINANCIAL OFFICER | Oct 19 | Oct 21 | S | 6,018 | $38.48 | Sale −$231,546 | 38,000 | Yes | Form 4 |
| Hohl BenjaminCHIEF FINANCIAL OFFICER | Oct 19 | Oct 21 | M · derivative | 6,018 | $14.85 | $89,367 | 175,000 | Yes | Form 4 |
| Collins Helen LouiseCHIEF MEDICAL OFFICER | Oct 19 | Oct 21 | M | 5,000 | $2.48 | $12,400 | 30,000 | Yes | Form 4 |
| Collins Helen LouiseCHIEF MEDICAL OFFICER | Oct 19 | Oct 21 | S | 5,000 | $38.47 | Sale −$192,342 | 25,000 | Yes | Form 4 |
| Collins Helen LouiseCHIEF MEDICAL OFFICER | Oct 19 | Oct 21 | M · derivative | 5,000 | $2.48 | $12,400 | 101,268 | Yes | Form 4 |
| Ball Kristine M | Oct 14 | Oct 16 | A · derivative | 23,394 | $39.28 | $918,916 | 23,394 | No | Form 4 |
| Garland J. Scott | Oct 1 | Oct 5 | M | 13,000 | $15.47 | $201,110 | 13,000 | No | Form 4 |
| Garland J. Scott | Oct 1 | Oct 5 | S | 13,000 | $46.67 | Sale −$606,719 | not reported | No | Form 4 |
| Garland J. Scott | Oct 1 | Oct 5 | M · derivative | 13,000 | $15.47 | $201,110 | 46,372 | No | Form 4 |
| Collins Helen LouiseCHIEF MEDICAL OFFICER | Sep 17 | Sep 21 | M | 5,000 | $2.48 | $12,400 | 30,000 | Yes | Form 4 |
| Collins Helen LouiseCHIEF MEDICAL OFFICER | Sep 17 | Sep 21 | S | 2,916 | $50.03 | Sale −$145,887 | 27,084 | Yes | Form 4 |
| Collins Helen LouiseCHIEF MEDICAL OFFICER | Sep 17 | Sep 21 | S | 1,844 | $50.71 | Sale −$93,509 | 25,240 | Yes | Form 4 |
| Collins Helen LouiseCHIEF MEDICAL OFFICER | Sep 17 | Sep 21 | S | 240 | $51.48 | Sale −$12,355 | 25,000 | Yes | Form 4 |
| Collins Helen LouiseCHIEF MEDICAL OFFICER | Sep 17 | Sep 21 | M · derivative | 5,000 | $2.48 | $12,400 | 106,268 | Yes | Form 4 |
| Hohl BenjaminCHIEF FINANCIAL OFFICER | Sep 17 | Sep 21 | M | 3,982 | $14.85 | $59,133 | 44,018 | Yes | Form 4 |
| Hohl BenjaminCHIEF FINANCIAL OFFICER | Sep 17 | Sep 21 | S | 3,535 | $50.03 | Sale −$176,856 | 40,483 | Yes | Form 4 |
| Hohl BenjaminCHIEF FINANCIAL OFFICER | Sep 17 | Sep 21 | S | 2,194 | $50.72 | Sale −$111,280 | 38,289 | Yes | Form 4 |
| Hohl BenjaminCHIEF FINANCIAL OFFICER | Sep 17 | Sep 21 | S | 289 | $51.49 | Sale −$14,881 | 38,000 | Yes | Form 4 |
| Hohl BenjaminCHIEF FINANCIAL OFFICER | Sep 17 | Sep 21 | M · derivative | 3,982 | $14.85 | $59,133 | 181,018 | Yes | Form 4 |
| Collins Helen LouiseCHIEF MEDICAL OFFICER | Aug 17 | Aug 19 | M | 5,000 | $2.48 | $12,400 | 30,000 | Yes | Form 4 |
| Collins Helen LouiseCHIEF MEDICAL OFFICER | Aug 17 | Aug 19 | S | 3,900 | $58.37 | Sale −$227,643 | 26,100 | Yes | Form 4 |
| Collins Helen LouiseCHIEF MEDICAL OFFICER | Aug 17 | Aug 19 | S | 1,100 | $59.35 | Sale −$65,285 | 25,000 | Yes | Form 4 |
| Collins Helen LouiseCHIEF MEDICAL OFFICER | Aug 17 | Aug 19 | M · derivative | 5,000 | $2.48 | $12,400 | 111,268 | Yes | Form 4 |
| Hohl BenjaminCHIEF FINANCIAL OFFICER | Aug 17 | Aug 19 | S | 4,630 | $58.35 | Sale −$270,161 | 41,424 | Yes | Form 4 |
| Hohl BenjaminCHIEF FINANCIAL OFFICER | Aug 17 | Aug 19 | S | 1,388 | $59.35 | Sale −$82,378 | 40,036 | Yes | Form 4 |
| Derynck Mika K | Aug 4 | Aug 6 | M | 87,373 | $2.48 | $216,685 | 87,373 | Yes | Form 4 |
| Derynck Mika K | Aug 4 | Aug 6 | M | 27,567 | $25.28 | $696,894 | 114,940 | Yes | Form 4 |
| Derynck Mika K | Aug 4 | Aug 6 | M | 23,364 | $14.85 | $346,955 | 138,304 | Yes | Form 4 |
| Derynck Mika K | Aug 4 | Aug 6 | M | 20,491 | $22.47 | $460,433 | 158,795 | Yes | Form 4 |
| Derynck Mika K | Aug 4 | Aug 6 | S | 158,795 | $60.21 | Sale −$9,561,047 | not reported | Yes | Form 4 |
| Derynck Mika K | Aug 4 | Aug 6 | M · derivative | 87,373 | $2.48 | $216,685 | not reported | Yes | Form 4 |
| Derynck Mika K | Aug 4 | Aug 6 | M · derivative | 27,567 | $25.28 | $696,894 | not reported | Yes | Form 4 |
| Derynck Mika K | Aug 4 | Aug 6 | M · derivative | 23,364 | $14.85 | $346,955 | not reported | Yes | Form 4 |
| Derynck Mika K | Aug 4 | Aug 6 | M · derivative | 20,491 | $22.47 | $460,433 | not reported | Yes | Form 4 |
| Collins Helen LouiseCHIEF MEDICAL OFFICER | Jul 17 | Jul 21 | M | 5,000 | $2.48 | $12,400 | 30,000 | Yes | Form 4 |
| Collins Helen LouiseCHIEF MEDICAL OFFICER | Jul 17 | Jul 21 | S | 231 | $50.05 | Sale −$11,562 | 29,769 | Yes | Form 4 |
| Collins Helen LouiseCHIEF MEDICAL OFFICER | Jul 17 | Jul 21 | S | 459 | $51.55 | Sale −$23,661 | 29,310 | Yes | Form 4 |
| Collins Helen LouiseCHIEF MEDICAL OFFICER | Jul 17 | Jul 21 | S | 2,063 | $52.39 | Sale −$108,081 | 27,247 | Yes | Form 4 |
| Collins Helen LouiseCHIEF MEDICAL OFFICER | Jul 17 | Jul 21 | S | 2,184 | $53.42 | Sale −$116,669 | 25,063 | Yes | Form 4 |
| Collins Helen LouiseCHIEF MEDICAL OFFICER | Jul 17 | Jul 21 | S | 63 | $53.92 | Sale −$3,397 | 25,000 | Yes | Form 4 |
| Collins Helen LouiseCHIEF MEDICAL OFFICER | Jul 17 | Jul 21 | M · derivative | 5,000 | $2.48 | $12,400 | 116,268 | Yes | Form 4 |
| Hohl BenjaminCHIEF FINANCIAL OFFICER | Jul 17 | Jul 21 | M | 1,072 | $2.48 | $2,659 | 52,072 | Yes | Form 4 |
| Hohl BenjaminCHIEF FINANCIAL OFFICER | Jul 17 | Jul 21 | S | 324 | $49.97 | Sale −$16,190 | 51,748 | Yes | Form 4 |
| Hohl BenjaminCHIEF FINANCIAL OFFICER | Jul 17 | Jul 21 | S | 369 | $51.48 | Sale −$18,996 | 51,379 | Yes | Form 4 |
| Hohl BenjaminCHIEF FINANCIAL OFFICER | Jul 17 | Jul 21 | S | 2,564 | $52.32 | Sale −$134,148 | 48,815 | Yes | Form 4 |
| Hohl BenjaminCHIEF FINANCIAL OFFICER | Jul 17 | Jul 21 | S | 2,638 | $53.38 | Sale −$140,816 | 46,177 | Yes | Form 4 |
| Hohl BenjaminCHIEF FINANCIAL OFFICER | Jul 17 | Jul 21 | S | 123 | $53.87 | Sale −$6,626 | 46,054 | Yes | Form 4 |
| Hohl BenjaminCHIEF FINANCIAL OFFICER | Jul 17 | Jul 21 | M · derivative | 1,072 | $2.48 | $2,659 | 84,966 | Yes | Form 4 |
| Kunkel Lori Anne | Jul 6 | Jul 8 | S | 4,111 | $49.98 | Sale −$205,468 | 47,773 | Yes | Form 4 |
| Kunkel Lori Anne | Jul 6 | Jul 8 | S | 5,889 | $50.84 | Sale −$299,397 | 41,884 | Yes | Form 4 |
| Orbimed Advisors LLC | Jun 22 | Jun 24 | S | 24,846 | $45.38 | Sale −$1,127,511 | 220,882 | No | Form 4 |
| Orbimed Advisors LLC | Jun 22 | Jun 24 | S | 1,477 | $45.00 | Sale −$66,465 | 219,405 | No | Form 4 |
| Orbimed Advisors LLC | Jun 22 | Jun 24 | S | 787,024 | $45.38 | Sale −$35,715,149 | 6,601,878 | No | Form 4 |
| Orbimed Advisors LLC | Jun 22 | Jun 24 | S | 46,776 | $45.00 | Sale −$2,104,920 | 6,555,102 | No | Form 4 |
| Collins Helen LouiseCHIEF MEDICAL OFFICER | Jun 17 | Jun 22 | M | 5,000 | $2.48 | $12,400 | 30,000 | Yes | Form 4 |
| Collins Helen LouiseCHIEF MEDICAL OFFICER | Jun 17 | Jun 22 | S | 1,268 | $42.83 | Sale −$54,308 | 28,732 | Yes | Form 4 |
| Collins Helen LouiseCHIEF MEDICAL OFFICER | Jun 17 | Jun 22 | S | 2,599 | $43.87 | Sale −$114,018 | 26,133 | Yes | Form 4 |
| Collins Helen LouiseCHIEF MEDICAL OFFICER | Jun 17 | Jun 22 | S | 1,133 | $44.74 | Sale −$50,690 | 25,000 | Yes | Form 4 |
| Collins Helen LouiseCHIEF MEDICAL OFFICER | Jun 17 | Jun 22 | M · derivative | 5,000 | $2.48 | $12,400 | 121,268 | Yes | Form 4 |
| Hohl BenjaminCHIEF FINANCIAL OFFICER | Jun 17 | Jun 22 | M | 6,018 | $2.48 | $14,925 | 57,018 | Yes | Form 4 |
| Hohl BenjaminCHIEF FINANCIAL OFFICER | Jun 17 | Jun 22 | S | 1,379 | $42.79 | Sale −$59,007 | 55,639 | Yes | Form 4 |
| Hohl BenjaminCHIEF FINANCIAL OFFICER | Jun 17 | Jun 22 | S | 3,401 | $43.86 | Sale −$149,168 | 52,238 | Yes | Form 4 |
| Hohl BenjaminCHIEF FINANCIAL OFFICER | Jun 17 | Jun 22 | S | 1,238 | $44.75 | Sale −$55,401 | 51,000 | Yes | Form 4 |
| Hohl BenjaminCHIEF FINANCIAL OFFICER | Jun 17 | Jun 22 | M · derivative | 6,018 | $2.48 | $14,925 | 86,038 | Yes | Form 4 |
| Orbimed Advisors LLC | Jun 15 | Jun 17 | S | 9,086 | $45.02 | Sale −$409,052 | 245,728 | No | Form 4 |
| Orbimed Advisors LLC | Jun 15 | Jun 17 | S | 272,322 | $45.02 | Sale −$12,259,936 | 7,388,902 | No | Form 4 |
| Kunkel Lori Anne | Jun 5 | Jun 9 | S | 7,779 | $34.28 | Sale −$266,664 | 54,105 | Yes | Form 4 |
| Kunkel Lori Anne | Jun 5 | Jun 9 | S | 1,867 | $35.36 | Sale −$66,017 | 52,238 | Yes | Form 4 |
| Kunkel Lori Anne | Jun 5 | Jun 9 | S | 354 | $35.82 | Sale −$12,680 | 51,884 | Yes | Form 4 |
| Collins Helen LouiseCHIEF MEDICAL OFFICER | May 18 | May 20 | M | 5,000 | $2.48 | $12,400 | 30,000 | Yes | Form 4 |
| Collins Helen LouiseCHIEF MEDICAL OFFICER | May 18 | May 20 | S | 3,475 | $39.53 | Sale −$137,367 | 26,525 | Yes | Form 4 |
| Collins Helen LouiseCHIEF MEDICAL OFFICER | May 18 | May 20 | S | 1,302 | $40.25 | Sale −$52,406 | 25,223 | Yes | Form 4 |
| Collins Helen LouiseCHIEF MEDICAL OFFICER | May 18 | May 20 | S | 223 | $41.21 | Sale −$9,190 | 25,000 | Yes | Form 4 |
| Collins Helen LouiseCHIEF MEDICAL OFFICER | May 18 | May 20 | M · derivative | 5,000 | $2.48 | $12,400 | 126,268 | Yes | Form 4 |
| Collins Helen LouiseCHIEF MEDICAL OFFICER | Apr 17 | Apr 21 | M | 5,000 | $2.48 | $12,400 | 30,000 | Yes | Form 4 |
| Collins Helen LouiseCHIEF MEDICAL OFFICER | Apr 17 | Apr 21 | S | 140 | $45.81 | Sale −$6,413 | 29,860 | Yes | Form 4 |
| Collins Helen LouiseCHIEF MEDICAL OFFICER | Apr 17 | Apr 21 | S | 2,419 | $47.39 | Sale −$114,636 | 27,441 | Yes | Form 4 |
| Collins Helen LouiseCHIEF MEDICAL OFFICER | Apr 17 | Apr 21 | S | 2,441 | $48.06 | Sale −$117,314 | 25,000 | Yes | Form 4 |
| Collins Helen LouiseCHIEF MEDICAL OFFICER | Apr 17 | Apr 21 | M · derivative | 5,000 | $2.48 | $12,400 | 131,268 | Yes | Form 4 |
| Collins Helen LouiseCHIEF MEDICAL OFFICER | Mar 25 | Mar 27 | M | 40,000 | $2.48 | $99,200 | 65,000 | Yes | Form 4 |
| Collins Helen LouiseCHIEF MEDICAL OFFICER | Mar 25 | Mar 27 | S | 40,000 | $35.10 | Sale −$1,404,000 | 25,000 | Yes | Form 4 |
| Collins Helen LouiseCHIEF MEDICAL OFFICER | Mar 25 | Mar 27 | M · derivative | 40,000 | $2.48 | $99,200 | 136,268 | Yes | Form 4 |
| Collins Helen LouiseCHIEF MEDICAL OFFICER | Mar 17 | Mar 19 | M | 5,000 | $2.48 | $12,400 | 30,000 | Yes | Form 4 |
| Collins Helen LouiseCHIEF MEDICAL OFFICER | Mar 17 | Mar 19 | S | 5,000 | $27.76 | Sale −$138,800 | 25,000 | Yes | Form 4 |
| Collins Helen LouiseCHIEF MEDICAL OFFICER | Mar 17 | Mar 19 | M · derivative | 5,000 | $2.48 | $12,400 | 176,268 | Yes | Form 4 |
| Collins Helen LouiseCHIEF MEDICAL OFFICER | Mar 10 | Mar 11 | M | 10,129 | $2.48 | $25,120 | 35,129 | Yes | Form 4 |
| Collins Helen LouiseCHIEF MEDICAL OFFICER | Mar 10 | Mar 11 | S | 10,129 | $30.19 | Sale −$305,795 | 25,000 | Yes | Form 4 |
| Collins Helen LouiseCHIEF MEDICAL OFFICER | Mar 10 | Mar 11 | M · derivative | 10,129 | $2.48 | $25,120 | 181,268 | Yes | Form 4 |
| Collins Helen LouiseCHIEF MEDICAL OFFICER | Mar 9 | Mar 11 | M | 29,871 | $2.48 | $74,080 | 54,871 | Yes | Form 4 |
| Collins Helen LouiseCHIEF MEDICAL OFFICER | Mar 9 | Mar 11 | S | 29,871 | $30.02 | Sale −$896,727 | 25,000 | Yes | Form 4 |
| Collins Helen LouiseCHIEF MEDICAL OFFICER | Mar 9 | Mar 11 | M · derivative | 29,871 | $2.48 | $74,080 | 191,397 | Yes | Form 4 |
| Hohl BenjaminCHIEF FINANCIAL OFFICER | Mar 6 | Mar 10 | S | 10,000 | $29.58 | Sale −$295,800 | 51,000 | No | Form 4 |
| Heyman Richard A. | Feb 17 | Feb 19 | S | 1,230 | $26.18 | Sale −$32,201 | 22,647 | Yes | Form 4 |
| Collins Helen LouiseCHIEF MEDICAL OFFICER | Feb 17 | Feb 19 | M | 45,000 | $2.48 | $111,600 | 70,000 | Yes | Form 4 |
| Collins Helen LouiseCHIEF MEDICAL OFFICER | Feb 17 | Feb 19 | S | 45,000 | $26.17 | Sale −$1,177,650 | 25,000 | Yes | Form 4 |
| Collins Helen LouiseCHIEF MEDICAL OFFICER | Feb 17 | Feb 19 | M · derivative | 45,000 | $2.48 | $111,600 | 221,268 | Yes | Form 4 |
| Garland J. Scott | Feb 12 | Feb 17 | A · derivative | 1,427 | $27.16 | $38,757 | 1,427 | No | Form 4 |
| Kunkel Lori Anne | Feb 12 | Feb 17 | A · derivative | 17,126 | $27.16 | $465,142 | 17,126 | No | Form 4 |
| Gupta Rishi | Feb 12 | Feb 17 | A · derivative | 33,989 | $27.16 | $923,141 | 33,989 | No | Form 4 |
| Gupta Rishi | Feb 12 | Feb 17 | A · derivative | 1,580 | $27.16 | $42,913 | 1,580 | No | Form 4 |
| Heyman Richard A. | Feb 12 | Feb 17 | A · derivative | 19,234 | $27.16 | $522,395 | 19,234 | No | Form 4 |
| Bauer Jake | Feb 12 | Feb 17 | A · derivative | 17,126 | $27.16 | $465,142 | 17,126 | No | Form 4 |
| Collins Helen LouiseCHIEF MEDICAL OFFICER | Feb 12 | Feb 17 | A | 25,000 | $0.00 | $0 | 25,000 | No | Form 4 |
| Collins Helen LouiseCHIEF MEDICAL OFFICER | Feb 12 | Feb 17 | A · derivative | 150,000 | $27.16 | $4,074,000 | 150,000 | No | Form 4 |
| Ballal Rahul D. | Feb 12 | Feb 17 | A · derivative | 17,126 | $27.16 | $465,142 | 17,126 | No | Form 4 |
| Derynck Mika K | Feb 12 | Feb 17 | A · derivative | 17,126 | $27.16 | $465,142 | 17,126 | No | Form 4 |
| Hohl BenjaminCHIEF FINANCIAL OFFICER | Feb 12 | Feb 17 | A | 25,000 | $0.00 | $0 | 61,000 | No | Form 4 |
| Hohl BenjaminCHIEF FINANCIAL OFFICER | Feb 12 | Feb 17 | A · derivative | 150,000 | $27.16 | $4,074,000 | 150,000 | No | Form 4 |
| Lyssikatos Joseph PCHIEF SCIENTIFIC OFFICER | Feb 12 | Feb 17 | A | 18,750 | $0.00 | $0 | 18,750 | No | Form 4 |
| Lyssikatos Joseph PCHIEF SCIENTIFIC OFFICER | Feb 12 | Feb 17 | A · derivative | 112,500 | $27.16 | $3,055,500 | 112,500 | No | Form 4 |
| Patel AnishCHIEF OPERATING OFFICER | Feb 12 | Feb 17 | A | 20,000 | $0.00 | $0 | 20,000 | No | Form 4 |
| Patel AnishCHIEF OPERATING OFFICER | Feb 12 | Feb 17 | A · derivative | 120,000 | $27.16 | $3,259,200 | 120,000 | No | Form 4 |
| Lyssikatos Joseph PCHIEF SCIENTIFIC OFFICER | Feb 6 | Feb 10 | S | 5,000 | $29.04 | Sale −$145,200 | 740,188 | Yes | Form 4 |
| Heyman Richard A. | Jan 20 | Jan 22 | S | 512 | $26.46 | Sale −$13,548 | 24,595 | Yes | Form 4 |
| Heyman Richard A. | Jan 20 | Jan 22 | S | 718 | $26.96 | Sale −$19,357 | 23,877 | Yes | Form 4 |
| Lyssikatos Joseph PCHIEF SCIENTIFIC OFFICER | Jan 20 | Jan 22 | S | 5,491 | $26.37 | Sale −$144,798 | 759,697 | Yes | Form 4 |
| Lyssikatos Joseph PCHIEF SCIENTIFIC OFFICER | Jan 20 | Jan 22 | S | 14,509 | $26.90 | Sale −$390,292 | 745,188 | Yes | Form 4 |
| Patel AnishCHIEF OPERATING OFFICER | Jan 9 | Jan 13 | S | 48,057 | $27.98 | Sale −$1,344,635 | 215,254 | Yes | Form 4 |
| Patel AnishCHIEF OPERATING OFFICER | Jan 9 | Jan 13 | S | 243 | $28.50 | Sale −$6,926 | 215,011 | Yes | Form 4 |
| Heyman Richard A. | Jan 9 | Jan 12 | S | 4,285 | $25.00 | Sale −$107,125 | 25,107 | Yes | Form 4 |
| Lyssikatos Joseph PCHIEF SCIENTIFIC OFFICER | Jan 9 | Jan 12 | S | 41,198 | $24.90 | Sale −$1,025,830 | 815,188 | Yes | Form 4 |
| Lyssikatos Joseph PCHIEF SCIENTIFIC OFFICER | Jan 9 | Jan 12 | S | 50,000 | $29.13 | Sale −$1,456,500 | 765,188 | Yes | Form 4 |
| Heyman Richard A. | Jan 8 | Jan 12 | S | 1,620 | $25.00 | Sale −$40,500 | 25,545 | Yes | Form 4 |
| Heyman Richard A. | Jan 8 | Jan 12 | S | 8,015 | $25.04 | Sale −$200,696 | 29,392 | Yes | Form 4 |
| Lyssikatos Joseph PCHIEF SCIENTIFIC OFFICER | Jan 8 | Jan 12 | S | 7,500 | $20.13 | Sale −$150,975 | 890,188 | Yes | Form 4 |
| Lyssikatos Joseph PCHIEF SCIENTIFIC OFFICER | Jan 8 | Jan 12 | S | 33,802 | $24.92 | Sale −$842,346 | 856,386 | Yes | Form 4 |
| Garland J. Scott | Jan 7 | Jan 9 | A · derivative | 59,372 | $15.47 | $918,485 | 59,372 | No | Form 4 |
| Hohl BenjaminCHIEF FINANCIAL OFFICER | Dec 22, 2025 | Dec 23, 2025 | M | 13,000 | $2.48 | $32,240 | 36,000 | No | Form 4 |
| Hohl BenjaminCHIEF FINANCIAL OFFICER | Dec 22, 2025 | Dec 23, 2025 | M · derivative | 13,000 | $2.48 | $32,240 | 92,056 | No | Form 4 |
| Lyssikatos Joseph PCHIEF SCIENTIFIC OFFICER | Dec 19, 2025 | Dec 23, 2025 | S | 5,000 | $16.84 | Sale −$84,200 | 897,688 | Yes | Form 4 |
| Kunkel Lori Anne | Dec 17, 2025 | Dec 19, 2025 | M | 15,958 | $1.12 | $17,873 | 30,712 | No | Form 4 |
| Kunkel Lori Anne | Dec 17, 2025 | Dec 19, 2025 | M · derivative | 15,958 | $1.12 | $17,873 | 3,741 | No | Form 4 |
| Fair Richard A.PRESIDENT AND CEO | Dec 11, 2025 | Dec 12, 2025 | A · derivative | 875,000 | $18.77 | $16,423,750 | 875,000 | No | Form 4 |
| Patel AnishCHIEF OPERATING OFFICER | Dec 8, 2025 | Dec 10, 2025 | S | 4,958 | $20.76 | Sale −$102,928 | 265,016 | Yes | Form 4 |
| Patel AnishCHIEF OPERATING OFFICER | Dec 8, 2025 | Dec 10, 2025 | S | 1,705 | $21.78 | Sale −$37,135 | 263,311 | Yes | Form 4 |
| Lyssikatos Joseph PCHIEF SCIENTIFIC OFFICER | Nov 19, 2025 | Nov 21, 2025 | S | 12,008 | $22.30 | Sale −$267,778 | 903,180 | Yes | Form 4 |
| Lyssikatos Joseph PCHIEF SCIENTIFIC OFFICER | Nov 19, 2025 | Nov 21, 2025 | S | 492 | $23.09 | Sale −$11,360 | 902,688 | Yes | Form 4 |
| Kintz SamuelPRESIDENT AND CEO | Nov 17, 2025 | Nov 19, 2025 | S | 12,500 | $21.82 | Sale −$272,750 | 890,392 | Yes | Form 4 |
| Patel AnishCHIEF OPERATING OFFICER | Nov 7, 2025 | Nov 12, 2025 | S | 6,054 | $17.35 | Sale −$105,037 | 270,587 | Yes | Form 4 |
| Patel AnishCHIEF OPERATING OFFICER | Nov 7, 2025 | Nov 12, 2025 | S | 613 | $17.94 | Sale −$10,997 | 269,974 | Yes | Form 4 |
| Lyssikatos Joseph PCHIEF SCIENTIFIC OFFICER | Oct 20, 2025 | Oct 22, 2025 | S | 12,500 | $22.08 | Sale −$276,000 | 915,188 | Yes | Form 4 |
| Kintz SamuelPRESIDENT AND CEO | Oct 17, 2025 | Oct 21, 2025 | S | 12,500 | $21.33 | Sale −$266,625 | 902,892 | Yes | Form 4 |
| Patel AnishCHIEF OPERATING OFFICER | Oct 7, 2025 | Oct 9, 2025 | S | 6,667 | $20.10 | Sale −$134,007 | 276,641 | Yes | Form 4 |
| Hohl BenjaminCHIEF FINANCIAL OFFICER | Sep 29, 2025 | Oct 1, 2025 | M | 3,250 | $2.48 | $8,060 | 26,250 | Yes | Form 4 |
| Hohl BenjaminCHIEF FINANCIAL OFFICER | Sep 29, 2025 | Oct 1, 2025 | S | 3,250 | $20.40 | Sale −$66,300 | 23,000 | Yes | Form 4 |
| Hohl BenjaminCHIEF FINANCIAL OFFICER | Sep 29, 2025 | Oct 1, 2025 | M · derivative | 3,250 | $2.48 | $8,060 | 105,056 | Yes | Form 4 |
| Lyssikatos Joseph PCHIEF SCIENTIFIC OFFICER | Sep 26, 2025 | Sep 30, 2025 | S | 4,000 | $20.25 | Sale −$81,000 | 927,688 | Yes | Form 4 |
| Kintz SamuelPRESIDENT AND CEO | Sep 26, 2025 | Sep 30, 2025 | S | 3,700 | $20.06 | Sale −$74,222 | 915,392 | Yes | Form 4 |
| Lyssikatos Joseph PCHIEF SCIENTIFIC OFFICER | Sep 23, 2025 | Sep 25, 2025 | S | 1,500 | $20.03 | Sale −$30,045 | 931,688 | Yes | Form 4 |
| Kintz SamuelPRESIDENT AND CEO | Sep 23, 2025 | Sep 25, 2025 | S | 2,800 | $20.03 | Sale −$56,084 | 919,092 | Yes | Form 4 |
| Lyssikatos Joseph PCHIEF SCIENTIFIC OFFICER | Sep 19, 2025 | Sep 23, 2025 | S | 4,870 | $19.11 | Sale −$93,066 | 935,318 | Yes | Form 4 |
| Lyssikatos Joseph PCHIEF SCIENTIFIC OFFICER | Sep 19, 2025 | Sep 23, 2025 | S | 2,130 | $20.02 | Sale −$42,643 | 933,188 | Yes | Form 4 |
| Kintz SamuelPRESIDENT AND CEO | Sep 19, 2025 | Sep 19, 2025 | S | 1,000 | $20.25 | Sale −$20,250 | 921,892 | Yes | Form 4 |
| Kintz SamuelPRESIDENT AND CEO | Sep 17, 2025 | Sep 19, 2025 | S | 5,000 | $19.09 | Sale −$95,450 | 922,892 | Yes | Form 4 |
| Patel AnishCHIEF OPERATING OFFICER | Sep 8, 2025 | Sep 10, 2025 | S | 6,667 | $20.24 | Sale −$134,940 | 283,308 | Yes | Form 4 |
| Hohl BenjaminCHIEF FINANCIAL OFFICER | Aug 27, 2025 | Aug 29, 2025 | M | 3,250 | $2.48 | $8,060 | 26,250 | Yes | Form 4 |
| Hohl BenjaminCHIEF FINANCIAL OFFICER | Aug 27, 2025 | Aug 29, 2025 | S | 3,250 | $20.63 | Sale −$67,048 | 23,000 | Yes | Form 4 |
| Hohl BenjaminCHIEF FINANCIAL OFFICER | Aug 27, 2025 | Aug 29, 2025 | M · derivative | 3,250 | $2.48 | $8,060 | 108,306 | Yes | Form 4 |
| Lyssikatos Joseph PCHIEF SCIENTIFIC OFFICER | Aug 21, 2025 | Aug 21, 2025 | S | 7,500 | $20.01 | Sale −$150,075 | 940,188 | Yes | Form 4 |
| Kintz SamuelPRESIDENT AND CEO | Aug 20, 2025 | Aug 21, 20254/A | S | 1,517 | $20.00 | Sale −$30,340 | 927,892 | Yes | Form 4/A |
| Lyssikatos Joseph PCHIEF SCIENTIFIC OFFICER | Aug 19, 2025 | Aug 21, 2025 | S | 5,000 | $19.62 | Sale −$98,100 | 947,688 | Yes | Form 4 |
| Patel AnishCHIEF OPERATING OFFICER | Aug 7, 2025 | Aug 11, 2025 | S | 6,262 | $18.20 | Sale −$113,968 | 290,380 | Yes | Form 4 |
| Patel AnishCHIEF OPERATING OFFICER | Aug 7, 2025 | Aug 11, 2025 | S | 405 | $18.93 | Sale −$7,667 | 289,975 | Yes | Form 4 |
| Hohl BenjaminCHIEF FINANCIAL OFFICER | Jul 28, 2025 | Jul 30, 2025 | M | 3,250 | $2.48 | $8,060 | 26,250 | Yes | Form 4 |
| Hohl BenjaminCHIEF FINANCIAL OFFICER | Jul 28, 2025 | Jul 30, 2025 | S | 3,185 | $20.45 | Sale −$65,133 | 23,065 | Yes | Form 4 |
| Hohl BenjaminCHIEF FINANCIAL OFFICER | Jul 28, 2025 | Jul 30, 2025 | S | 65 | $21.30 | Sale −$1,385 | 23,000 | Yes | Form 4 |
| Hohl BenjaminCHIEF FINANCIAL OFFICER | Jul 28, 2025 | Jul 30, 2025 | M · derivative | 3,250 | $2.48 | $8,060 | 111,556 | Yes | Form 4 |
| Lyssikatos Joseph PCHIEF SCIENTIFIC OFFICER | Jul 21, 2025 | Jul 23, 2025 | S | 11,924 | $22.26 | Sale −$265,428 | 953,264 | Yes | Form 4 |
| Lyssikatos Joseph PCHIEF SCIENTIFIC OFFICER | Jul 21, 2025 | Jul 23, 2025 | S | 576 | $22.90 | Sale −$13,190 | 952,688 | Yes | Form 4 |
| Kintz SamuelPRESIDENT AND CEO | Jul 17, 2025 | Jul 21, 2025 | S | 4,150 | $21.58 | Sale −$89,557 | 948,742 | Yes | Form 4 |
| Kintz SamuelPRESIDENT AND CEO | Jul 17, 2025 | Jul 21, 2025 | S | 4,687 | $22.69 | Sale −$106,348 | 944,055 | Yes | Form 4 |
| Kintz SamuelPRESIDENT AND CEO | Jul 17, 2025 | Jul 21, 2025 | S | 3,663 | $23.37 | Sale −$85,604 | 940,392 | Yes | Form 4 |
| Hohl BenjaminCHIEF FINANCIAL OFFICER | Jul 10, 2025 | Jul 14, 2025 | M | 1,000 | $2.48 | $2,480 | 24,000 | Yes | Form 4 |
| Hohl BenjaminCHIEF FINANCIAL OFFICER | Jul 10, 2025 | Jul 14, 2025 | S | 1,000 | $22.66 | Sale −$22,660 | 23,000 | Yes | Form 4 |
| Hohl BenjaminCHIEF FINANCIAL OFFICER | Jul 10, 2025 | Jul 14, 2025 | M · derivative | 1,000 | $2.48 | $2,480 | 114,806 | Yes | Form 4 |
| Patel AnishCHIEF OPERATING OFFICER | Jul 7, 2025 | Jul 9, 2025 | S | 6,362 | $19.75 | Sale −$125,650 | 296,947 | Yes | Form 4 |
| Patel AnishCHIEF OPERATING OFFICER | Jul 7, 2025 | Jul 9, 2025 | S | 305 | $20.69 | Sale −$6,310 | 296,642 | Yes | Form 4 |
| Hohl BenjaminCHIEF FINANCIAL OFFICER | Jun 27, 2025 | Jul 1, 2025 | M | 3,250 | $2.48 | $8,060 | 26,250 | Yes | Form 4 |
| Hohl BenjaminCHIEF FINANCIAL OFFICER | Jun 27, 2025 | Jul 1, 2025 | S | 3,052 | $20.86 | Sale −$63,665 | 23,198 | Yes | Form 4 |
| Hohl BenjaminCHIEF FINANCIAL OFFICER | Jun 27, 2025 | Jul 1, 2025 | S | 198 | $21.66 | Sale −$4,289 | 23,000 | Yes | Form 4 |
| Hohl BenjaminCHIEF FINANCIAL OFFICER | Jun 27, 2025 | Jul 1, 2025 | M · derivative | 3,250 | $2.48 | $8,060 | 115,806 | Yes | Form 4 |
| Lyssikatos Joseph PCHIEF SCIENTIFIC OFFICER | Jun 20, 2025 | Jun 24, 2025 | S | 12,500 | $21.40 | Sale −$267,500 | 965,188 | Yes | Form 4 |
| Kintz SamuelPRESIDENT AND CEO | Jun 17, 2025 | Jun 18, 2025 | S | 10,502 | $22.08 | Sale −$231,884 | 954,890 | Yes | Form 4 |
| Kintz SamuelPRESIDENT AND CEO | Jun 17, 2025 | Jun 18, 2025 | S | 1,998 | $22.75 | Sale −$45,455 | 952,892 | Yes | Form 4 |
| Hohl BenjaminCHIEF FINANCIAL OFFICER | Jun 13, 2025 | Jun 17, 2025 | M | 3,000 | $2.48 | $7,440 | 26,000 | Yes | Form 4 |
| Hohl BenjaminCHIEF FINANCIAL OFFICER | Jun 13, 2025 | Jun 17, 2025 | S | 3,000 | $22.55 | Sale −$67,650 | 23,000 | Yes | Form 4 |
| Hohl BenjaminCHIEF FINANCIAL OFFICER | Jun 13, 2025 | Jun 17, 2025 | M · derivative | 3,000 | $2.48 | $7,440 | 119,056 | Yes | Form 4 |
| Patel AnishCHIEF OPERATING OFFICER | Jun 9, 2025 | Jun 11, 2025 | S | 6,607 | $20.33 | Sale −$134,320 | 303,369 | Yes | Form 4 |
| Patel AnishCHIEF OPERATING OFFICER | Jun 9, 2025 | Jun 11, 2025 | S | 60 | $21.16 | Sale −$1,270 | 303,309 | Yes | Form 4 |
| Kintz SamuelPRESIDENT AND CEO | Jun 3, 2025 | Jun 5, 2025 | S | 7,500 | $20.05 | Sale −$150,375 | 965,392 | Yes | Form 4 |
| Lyssikatos Joseph PCHIEF SCIENTIFIC OFFICER | Jun 3, 2025 | Jun 5, 2025 | S | 7,500 | $20.03 | Sale −$150,225 | 977,688 | Yes | Form 4 |
| Hohl BenjaminCHIEF FINANCIAL OFFICER | May 27, 2025 | May 29, 2025 | M | 3,250 | $2.48 | $8,060 | 26,250 | Yes | Form 4 |
| Hohl BenjaminCHIEF FINANCIAL OFFICER | May 27, 2025 | May 29, 2025 | S | 3,250 | $16.18 | Sale −$52,585 | 23,000 | Yes | Form 4 |
| Hohl BenjaminCHIEF FINANCIAL OFFICER | May 27, 2025 | May 29, 2025 | M · derivative | 3,250 | $2.48 | $8,060 | 122,056 | Yes | Form 4 |
| Kintz SamuelPRESIDENT AND CEO | May 19, 2025 | May 21, 2025 | S | 5,000 | $16.49 | Sale −$82,450 | 972,892 | Yes | Form 4 |
| Lyssikatos Joseph PCHIEF SCIENTIFIC OFFICER | May 19, 2025 | May 21, 2025 | S | 5,000 | $16.31 | Sale −$81,550 | 985,188 | Yes | Form 4 |
| Patel AnishCHIEF OPERATING OFFICER | May 7, 2025 | May 9, 2025 | S | 6,173 | $18.30 | Sale −$112,966 | 310,470 | Yes | Form 4 |
| Patel AnishCHIEF OPERATING OFFICER | May 7, 2025 | May 9, 2025 | S | 390 | $19.40 | Sale −$7,566 | 310,080 | Yes | Form 4 |
| Patel AnishCHIEF OPERATING OFFICER | May 7, 2025 | May 9, 2025 | S | 104 | $19.87 | Sale −$2,066 | 309,976 | Yes | Form 4 |
| Kintz SamuelPRESIDENT AND CEO | May 2, 2025 | May 5, 2025 | S | 2,170 | $20.00 | Sale −$43,400 | 977,892 | Yes | Form 4 |
| Lyssikatos Joseph PCHIEF SCIENTIFIC OFFICER | May 2, 2025 | May 5, 2025 | S | 2,470 | $20.01 | Sale −$49,425 | 990,188 | Yes | Form 4 |
| Kintz SamuelPRESIDENT AND CEO | May 1, 2025 | May 5, 2025 | S | 5,330 | $20.08 | Sale −$107,026 | 980,062 | Yes | Form 4 |
| Lyssikatos Joseph PCHIEF SCIENTIFIC OFFICER | May 1, 2025 | May 5, 2025 | S | 5,030 | $20.07 | Sale −$100,952 | 992,658 | Yes | Form 4 |
| Hohl BenjaminCHIEF FINANCIAL OFFICER | Apr 28, 2025 | Apr 30, 2025 | M | 3,250 | $2.48 | $8,060 | 26,250 | Yes | Form 4 |
| Hohl BenjaminCHIEF FINANCIAL OFFICER | Apr 28, 2025 | Apr 30, 2025 | S | 3,181 | $18.68 | Sale −$59,421 | 23,069 | Yes | Form 4 |
| Hohl BenjaminCHIEF FINANCIAL OFFICER | Apr 28, 2025 | Apr 30, 2025 | S | 69 | $19.12 | Sale −$1,319 | 23,000 | Yes | Form 4 |
| Hohl BenjaminCHIEF FINANCIAL OFFICER | Apr 28, 2025 | Apr 30, 2025 | M · derivative | 3,250 | $2.48 | $8,060 | 125,306 | Yes | Form 4 |
| Lyssikatos Joseph PCHIEF SCIENTIFIC OFFICER | Apr 21, 2025 | Apr 23, 2025 | S | 4,670 | $16.03 | Sale −$74,860 | 998,018 | Yes | Form 4 |
| Lyssikatos Joseph PCHIEF SCIENTIFIC OFFICER | Apr 21, 2025 | Apr 23, 2025 | S | 330 | $16.72 | Sale −$5,518 | 997,688 | Yes | Form 4 |
| Kintz SamuelPRESIDENT AND CEO | Apr 17, 2025 | Apr 21, 2025 | S | 5,000 | $16.42 | Sale −$82,100 | 985,392 | Yes | Form 4 |
| Patel AnishCHIEF OPERATING OFFICER | Apr 7, 2025 | Apr 9, 2025 | S | 3,756 | $17.81 | Sale −$66,894 | 319,554 | Yes | Form 4 |
| Patel AnishCHIEF OPERATING OFFICER | Apr 7, 2025 | Apr 9, 2025 | S | 2,763 | $18.29 | Sale −$50,535 | 316,791 | Yes | Form 4 |
| Patel AnishCHIEF OPERATING OFFICER | Apr 7, 2025 | Apr 9, 2025 | S | 148 | $19.27 | Sale −$2,852 | 316,643 | Yes | Form 4 |
| Hohl BenjaminCHIEF FINANCIAL OFFICER | Mar 27, 2025 | Mar 31, 2025 | M | 3,250 | $2.48 | $8,060 | 26,250 | Yes | Form 4 |
| Hohl BenjaminCHIEF FINANCIAL OFFICER | Mar 27, 2025 | Mar 31, 2025 | S | 3,250 | $21.33 | Sale −$69,323 | 23,000 | Yes | Form 4 |
| Hohl BenjaminCHIEF FINANCIAL OFFICER | Mar 27, 2025 | Mar 31, 2025 | M · derivative | 3,250 | $2.48 | $8,060 | 128,556 | Yes | Form 4 |
| Hohl BenjaminCHIEF FINANCIAL OFFICER | Mar 24, 2025 | Mar 26, 2025 | M | 1,000 | $2.48 | $2,480 | 24,000 | Yes | Form 4 |
| Hohl BenjaminCHIEF FINANCIAL OFFICER | Mar 24, 2025 | Mar 26, 2025 | S | 1,000 | $22.50 | Sale −$22,500 | 23,000 | Yes | Form 4 |
| Hohl BenjaminCHIEF FINANCIAL OFFICER | Mar 24, 2025 | Mar 26, 2025 | M · derivative | 1,000 | $2.48 | $2,480 | 131,806 | Yes | Form 4 |
| Lyssikatos Joseph PCHIEF SCIENTIFIC OFFICER | Mar 19, 2025 | Mar 21, 2025 | S | 12,500 | $20.61 | Sale −$257,625 | 1,002,688 | Yes | Form 4 |
| Kintz SamuelPRESIDENT AND CEO | Mar 17, 2025 | Mar 19, 2025 | S | 12,500 | $20.83 | Sale −$260,375 | 990,392 | Yes | Form 4 |
| Patel AnishCHIEF OPERATING OFFICER | Mar 7, 2025 | Mar 11, 2025 | S | 6,667 | $21.44 | Sale −$142,940 | 323,310 | Yes | Form 4 |
| Hohl BenjaminCHIEF FINANCIAL OFFICER | Mar 4, 2025 | Mar 6, 2025 | M | 10,000 | $2.48 | $24,800 | 23,000 | No | Form 4 |
| Hohl BenjaminCHIEF FINANCIAL OFFICER | Mar 4, 2025 | Mar 6, 2025 | M · derivative | 10,000 | $2.48 | $24,800 | 132,806 | No | Form 4 |
| Hohl BenjaminCHIEF FINANCIAL OFFICER | Feb 27, 2025 | Mar 3, 2025 | M | 3,250 | $2.48 | $8,060 | 16,250 | Yes | Form 4 |
| Hohl BenjaminCHIEF FINANCIAL OFFICER | Feb 27, 2025 | Mar 3, 2025 | S | 3,250 | $20.41 | Sale −$66,333 | 13,000 | Yes | Form 4 |
| Hohl BenjaminCHIEF FINANCIAL OFFICER | Feb 27, 2025 | Mar 3, 2025 | M · derivative | 3,250 | $2.48 | $8,060 | 142,806 | Yes | Form 4 |
| Patel AnishCHIEF OPERATING OFFICER | Feb 7, 2025 | Feb 10, 2025 | S | 6,667 | $21.93 | Sale −$146,207 | 329,977 | No | Form 4 |
| Collins Helen LouiseCHIEF MEDICAL OFFICER | Feb 6, 2025 | Feb 10, 2025 | A · derivative | 171,000 | $22.47 | $3,842,370 | 171,000 | No | Form 4 |
| Hohl BenjaminCHIEF FINANCIAL OFFICER | Feb 6, 2025 | Feb 10, 2025 | A · derivative | 171,000 | $22.47 | $3,842,370 | 171,000 | No | Form 4 |
| Kintz SamuelPRESIDENT AND CEO | Feb 6, 2025 | Feb 10, 2025 | A · derivative | 490,000 | $22.47 | $11,010,300 | 490,000 | No | Form 4 |
| Lyssikatos Joseph PCHIEF SCIENTIFIC OFFICER | Feb 6, 2025 | Feb 10, 2025 | A · derivative | 171,000 | $22.47 | $3,842,370 | 171,000 | No | Form 4 |
| Patel AnishCHIEF OPERATING OFFICER | Feb 6, 2025 | Feb 10, 2025 | A · derivative | 171,000 | $22.47 | $3,842,370 | 171,000 | No | Form 4 |
| Ballal Rahul D. | Feb 6, 2025 | Feb 10, 2025 | A · derivative | 20,491 | $22.47 | $460,433 | 20,491 | No | Form 4 |
| Bauer Jake | Feb 6, 2025 | Feb 10, 2025 | A · derivative | 20,491 | $22.47 | $460,433 | 20,491 | No | Form 4 |
| Derynck Mika K | Feb 6, 2025 | Feb 10, 2025 | A · derivative | 20,491 | $22.47 | $460,433 | 20,491 | No | Form 4 |
| Gupta Rishi | Feb 6, 2025 | Feb 10, 2025 | A · derivative | 20,491 | $22.47 | $460,433 | 20,491 | No | Form 4 |
| Heyman Richard A. | Feb 6, 2025 | Feb 10, 2025 | A · derivative | 23,014 | $22.47 | $517,125 | 23,014 | No | Form 4 |
| Kunkel Lori Anne | Feb 6, 2025 | Feb 10, 2025 | A · derivative | 15,368 | $22.47 | $345,319 | 15,368 | No | Form 4 |
| Phillips Andrew John | Feb 6, 2025 | Feb 10, 2025 | A · derivative | 20,491 | $22.47 | $460,433 | 20,491 | No | Form 4 |
| Hohl BenjaminCHIEF FINANCIAL OFFICER | Feb 5, 2025 | Feb 7, 2025 | M | 1,000 | $2.48 | $2,480 | 14,000 | Yes | Form 4 |
| Hohl BenjaminCHIEF FINANCIAL OFFICER | Feb 5, 2025 | Feb 7, 2025 | S | 1,000 | $22.52 | Sale −$22,520 | 13,000 | Yes | Form 4 |
| Hohl BenjaminCHIEF FINANCIAL OFFICER | Feb 5, 2025 | Feb 7, 2025 | M · derivative | 1,000 | $2.48 | $2,480 | 146,056 | Yes | Form 4 |
| Hohl BenjaminCHIEF FINANCIAL OFFICER | Jan 27, 2025 | Jan 29, 2025 | M | 3,250 | $2.48 | $8,060 | 16,250 | Yes | Form 4 |
| Hohl BenjaminCHIEF FINANCIAL OFFICER | Jan 27, 2025 | Jan 29, 2025 | S | 3,250 | $21.59 | Sale −$70,168 | 13,000 | Yes | Form 4 |
| Hohl BenjaminCHIEF FINANCIAL OFFICER | Jan 27, 2025 | Jan 29, 2025 | M · derivative | 3,250 | $2.48 | $8,060 | 147,056 | Yes | Form 4 |
| Patel AnishCHIEF OPERATING OFFICER | Jan 7, 2025 | Jan 10, 2025 | M | 10,700 | $1.12 | $11,984 | 10,700 | Yes | Form 4 |
| Patel AnishCHIEF OPERATING OFFICER | Jan 7, 2025 | Jan 10, 2025 | M | 2,000 | $2.48 | $4,960 | 12,700 | Yes | Form 4 |
| Patel AnishCHIEF OPERATING OFFICER | Jan 7, 2025 | Jan 10, 2025 | M | 9,000 | $2.48 | $22,320 | 21,700 | Yes | Form 4 |
| Patel AnishCHIEF OPERATING OFFICER | Jan 7, 2025 | Jan 10, 2025 | S | 20,260 | $24.15 | Sale −$489,279 | 1,440 | Yes | Form 4 |
| Patel AnishCHIEF OPERATING OFFICER | Jan 7, 2025 | Jan 10, 2025 | S | 1,440 | $24.56 | Sale −$35,366 | not reported | Yes | Form 4 |
| Patel AnishCHIEF OPERATING OFFICER | Jan 7, 2025 | Jan 10, 2025 | S | 6,577 | $24.17 | Sale −$158,966 | 336,734 | Yes | Form 4 |
| Patel AnishCHIEF OPERATING OFFICER | Jan 7, 2025 | Jan 10, 2025 | S | 90 | $24.60 | Sale −$2,214 | 336,644 | Yes | Form 4 |
| Patel AnishCHIEF OPERATING OFFICER | Jan 7, 2025 | Jan 10, 2025 | M · derivative | 10,700 | $1.12 | $11,984 | 67 | Yes | Form 4 |
| Patel AnishCHIEF OPERATING OFFICER | Jan 7, 2025 | Jan 10, 2025 | M · derivative | 2,000 | $2.48 | $4,960 | 827 | Yes | Form 4 |
| Patel AnishCHIEF OPERATING OFFICER | Jan 7, 2025 | Jan 10, 2025 | M · derivative | 9,000 | $2.48 | $22,320 | 44,342 | Yes | Form 4 |
| Hohl BenjaminCHIEF FINANCIAL OFFICER | Jan 3, 2025 | Jan 7, 2025 | M | 1,000 | $2.48 | $2,480 | 14,000 | Yes | Form 4 |
| Hohl BenjaminCHIEF FINANCIAL OFFICER | Jan 3, 2025 | Jan 7, 2025 | S | 1,000 | $25.04 | Sale −$25,040 | 13,000 | Yes | Form 4 |
| Hohl BenjaminCHIEF FINANCIAL OFFICER | Jan 3, 2025 | Jan 7, 2025 | M · derivative | 1,000 | $2.48 | $2,480 | 150,306 | Yes | Form 4 |
| Hohl BenjaminCHIEF FINANCIAL OFFICER | Dec 13, 2024 | Jan 7, 2025 | M | 13,000 | $2.48 | $32,240 | 13,000 | Yes | Form 4 |
| Hohl BenjaminCHIEF FINANCIAL OFFICER | Dec 13, 2024 | Jan 7, 2025 | M · derivative | 13,000 | $2.48 | $32,240 | 155,556 | Yes | Form 4 |
| Hohl BenjaminCHIEF FINANCIAL OFFICER | Dec 30, 2024 | Dec 31, 2024 | M | 900 | $2.48 | $2,232 | 900 | Yes | Form 4 |
| Hohl BenjaminCHIEF FINANCIAL OFFICER | Dec 30, 2024 | Dec 31, 2024 | S | 900 | $22.51 | Sale −$20,259 | not reported | Yes | Form 4 |
| Hohl BenjaminCHIEF FINANCIAL OFFICER | Dec 30, 2024 | Dec 31, 2024 | M · derivative | 900 | $2.48 | $2,232 | 164,306 | Yes | Form 4 |
| Hohl BenjaminCHIEF FINANCIAL OFFICER | Dec 27, 2024 | Dec 31, 2024 | M | 3,350 | $2.48 | $8,308 | 3,350 | Yes | Form 4 |
| Hohl BenjaminCHIEF FINANCIAL OFFICER | Dec 27, 2024 | Dec 31, 2024 | S | 3,350 | $22.15 | Sale −$74,203 | not reported | Yes | Form 4 |
| Hohl BenjaminCHIEF FINANCIAL OFFICER | Dec 27, 2024 | Dec 31, 2024 | M · derivative | 3,350 | $2.48 | $8,308 | 165,206 | Yes | Form 4 |
| Hohl BenjaminCHIEF FINANCIAL OFFICER | Nov 27, 2024 | Dec 2, 2024 | M | 5,250 | $2.48 | $13,020 | 5,250 | Yes | Form 4 |
| Hohl BenjaminCHIEF FINANCIAL OFFICER | Nov 27, 2024 | Dec 2, 2024 | S | 4,250 | $24.78 | Sale −$105,315 | 1,000 | Yes | Form 4 |
| Hohl BenjaminCHIEF FINANCIAL OFFICER | Nov 27, 2024 | Dec 2, 2024 | S | 1,000 | $25.38 | Sale −$25,380 | not reported | Yes | Form 4 |
| Hohl BenjaminCHIEF FINANCIAL OFFICER | Nov 27, 2024 | Dec 2, 2024 | M · derivative | 5,250 | $2.48 | $13,020 | 168,556 | Yes | Form 4 |
| Hohl BenjaminCHIEF FINANCIAL OFFICER | Oct 28, 2024 | Oct 30, 2024 | M | 6,250 | $2.48 | $15,500 | 6,250 | Yes | Form 4 |
| Hohl BenjaminCHIEF FINANCIAL OFFICER | Oct 28, 2024 | Oct 30, 2024 | S | 5,600 | $28.49 | Sale −$159,544 | 650 | Yes | Form 4 |
| Hohl BenjaminCHIEF FINANCIAL OFFICER | Oct 28, 2024 | Oct 30, 2024 | S | 650 | $29.11 | Sale −$18,922 | not reported | Yes | Form 4 |
| Hohl BenjaminCHIEF FINANCIAL OFFICER | Oct 28, 2024 | Oct 30, 2024 | M · derivative | 6,250 | $2.48 | $15,500 | 173,806 | Yes | Form 4 |
| Collins Helen LouiseCHIEF MEDICAL OFFICER | Oct 18, 2024 | Oct 22, 2024 | M | 816 | $2.48 | $2,024 | 816 | Yes | Form 4 |
| Collins Helen LouiseCHIEF MEDICAL OFFICER | Oct 18, 2024 | Oct 22, 2024 | S | 816 | $30.00 | Sale −$24,480 | not reported | Yes | Form 4 |
| Collins Helen LouiseCHIEF MEDICAL OFFICER | Oct 18, 2024 | Oct 22, 2024 | M · derivative | 816 | $2.48 | $2,024 | 266,268 | Yes | Form 4 |
| Heyman Richard A. | Oct 18, 2024 | Oct 22, 2024 | S | 817 | $30.00 | Sale −$24,510 | 123,673 | Yes | Form 4 |
| Heyman Richard A. | Oct 18, 2024 | Oct 22, 2024 | S | 753 | $30.00 | Sale −$22,590 | 27,165 | Yes | Form 4 |
| Hohl BenjaminCHIEF FINANCIAL OFFICER | Oct 18, 2024 | Oct 22, 2024 | M | 814 | $2.48 | $2,019 | 814 | Yes | Form 4 |
| Hohl BenjaminCHIEF FINANCIAL OFFICER | Oct 18, 2024 | Oct 22, 2024 | S | 814 | $30.00 | Sale −$24,420 | not reported | Yes | Form 4 |
| Hohl BenjaminCHIEF FINANCIAL OFFICER | Oct 18, 2024 | Oct 22, 2024 | M · derivative | 814 | $2.48 | $2,019 | 180,056 | Yes | Form 4 |
| Kintz SamuelPRESIDENT AND CEO | Oct 18, 2024 | Oct 22, 2024 | S | 924 | $30.00 | Sale −$27,720 | 1,002,892 | Yes | Form 4 |
| Lyssikatos Joseph PCHIEF SCIENTIFIC OFFICER | Oct 18, 2024 | Oct 22, 2024 | S | 847 | $30.00 | Sale −$25,410 | 1,015,188 | Yes | Form 4 |
| Patel AnishCHIEF OPERATING OFFICER | Oct 18, 2024 | Oct 22, 2024 | S | 716 | $30.00 | Sale −$21,480 | 343,311 | Yes | Form 4 |
| Heyman Richard A. | Oct 15, 2024 | Oct 17, 2024 | S | 1,270 | $27.67 | Sale −$35,141 | 124,490 | Yes | Form 4 |
| Kintz SamuelPRESIDENT AND CEO | Oct 9, 2024 | Oct 10, 2024 | S | 13,880 | $28.07 | Sale −$389,612 | 1,006,646 | Yes | Form 4 |
| Kintz SamuelPRESIDENT AND CEO | Oct 9, 2024 | Oct 10, 2024 | S | 2,830 | $28.53 | Sale −$80,740 | 1,003,816 | Yes | Form 4 |
| Lyssikatos Joseph PCHIEF SCIENTIFIC OFFICER | Oct 9, 2024 | Oct 10, 2024 | S | 34,289 | $28.12 | Sale −$964,207 | 1,019,624 | Yes | Form 4 |
| Lyssikatos Joseph PCHIEF SCIENTIFIC OFFICER | Oct 9, 2024 | Oct 10, 2024 | S | 3,589 | $28.52 | Sale −$102,358 | 1,016,035 | Yes | Form 4 |
| Ballal Rahul D. | Oct 8, 2024 | Oct 10, 2024 | M | 6,314 | $19.68 | $124,260 | 28,655 | Yes | Form 4 |
| Ballal Rahul D. | Oct 8, 2024 | Oct 10, 2024 | M | 4,106 | $5.52 | $22,665 | 32,761 | Yes | Form 4 |
| Ballal Rahul D. | Oct 8, 2024 | Oct 10, 2024 | S | 10,420 | $28.17 | Sale −$293,531 | 22,341 | Yes | Form 4 |
| Ballal Rahul D. | Oct 8, 2024 | Oct 10, 2024 | M · derivative | 6,314 | $19.68 | $124,260 | 69,428 | Yes | Form 4 |
| Ballal Rahul D. | Oct 8, 2024 | Oct 10, 2024 | M · derivative | 4,106 | $5.52 | $22,665 | 12,322 | Yes | Form 4 |
| Kintz SamuelPRESIDENT AND CEO | Oct 8, 2024 | Oct 10, 2024 | S | 13,167 | $27.95 | Sale −$368,018 | 1,020,626 | Yes | Form 4 |
| Kintz SamuelPRESIDENT AND CEO | Oct 8, 2024 | Oct 10, 2024 | S | 100 | $28.51 | Sale −$2,851 | 1,020,526 | Yes | Form 4 |
| Lyssikatos Joseph PCHIEF SCIENTIFIC OFFICER | Oct 8, 2024 | Oct 10, 2024 | S | 13,167 | $27.96 | Sale −$368,149 | 1,054,013 | Yes | Form 4 |
| Lyssikatos Joseph PCHIEF SCIENTIFIC OFFICER | Oct 8, 2024 | Oct 10, 2024 | S | 100 | $28.51 | Sale −$2,851 | 1,053,913 | Yes | Form 4 |
| Hohl BenjaminCHIEF FINANCIAL OFFICER | Oct 7, 2024 | Oct 8, 2024 | M | 1,270 | $2.48 | $3,150 | 2,000 | Yes | Form 4 |
| Hohl BenjaminCHIEF FINANCIAL OFFICER | Oct 7, 2024 | Oct 8, 2024 | S | 1,270 | $27.51 | Sale −$34,938 | not reported | Yes | Form 4 |
| Hohl BenjaminCHIEF FINANCIAL OFFICER | Oct 7, 2024 | Oct 8, 2024 | M · derivative | 1,270 | $2.48 | $3,150 | 180,870 | Yes | Form 4 |
| Kintz SamuelPRESIDENT AND CEO | Oct 7, 2024 | Oct 8, 2024 | S | 2,730 | $27.50 | Sale −$75,075 | 1,033,793 | Yes | Form 4 |
| Lyssikatos Joseph PCHIEF SCIENTIFIC OFFICER | Oct 7, 2024 | Oct 8, 2024 | S | 2,707 | $27.61 | Sale −$74,740 | 1,067,180 | Yes | Form 4 |
| Heyman Richard A. | Oct 4, 2024 | Oct 8, 2024 | S | 2,825 | $27.51 | Sale −$77,716 | 125,760 | Yes | Form 4 |
| Hohl BenjaminCHIEF FINANCIAL OFFICER | Oct 4, 2024 | Oct 8, 2024 | M | 10,218 | $2.48 | $25,341 | 10,218 | Yes | Form 4 |
| Hohl BenjaminCHIEF FINANCIAL OFFICER | Oct 4, 2024 | Oct 8, 2024 | S | 10,218 | $27.51 | Sale −$281,097 | not reported | Yes | Form 4 |
| Hohl BenjaminCHIEF FINANCIAL OFFICER | Oct 4, 2024 | Oct 8, 2024 | M · derivative | 10,218 | $2.48 | $25,341 | 182,140 | Yes | Form 4 |
| Kintz SamuelPRESIDENT AND CEO | Oct 4, 2024 | Oct 8, 2024 | S | 12,206 | $27.51 | Sale −$335,787 | 1,036,523 | Yes | Form 4 |
| Lyssikatos Joseph PCHIEF SCIENTIFIC OFFICER | Oct 4, 2024 | Oct 8, 2024 | S | 7,522 | $27.51 | Sale −$206,930 | 1,069,887 | Yes | Form 4 |
| Heyman Richard A. | Oct 1, 2024 | Oct 3, 2024 | S | 518 | $27.54 | Sale −$14,266 | 128,585 | Yes | Form 4 |
| Hohl BenjaminCHIEF FINANCIAL OFFICER | Oct 1, 2024 | Oct 3, 2024 | M | 521 | $2.48 | $1,292 | 521 | Yes | Form 4 |
| Hohl BenjaminCHIEF FINANCIAL OFFICER | Oct 1, 2024 | Oct 3, 2024 | S | 521 | $27.54 | Sale −$14,348 | not reported | Yes | Form 4 |
| Hohl BenjaminCHIEF FINANCIAL OFFICER | Oct 1, 2024 | Oct 3, 2024 | M · derivative | 521 | $2.48 | $1,292 | 192,358 | Yes | Form 4 |
| Kintz SamuelPRESIDENT AND CEO | Oct 1, 2024 | Oct 3, 2024 | S | 526 | $27.54 | Sale −$14,486 | 1,048,729 | Yes | Form 4 |
| Lyssikatos Joseph PCHIEF SCIENTIFIC OFFICER | Oct 1, 2024 | Oct 3, 2024 | S | 527 | $27.54 | Sale −$14,514 | 1,077,409 | Yes | Form 4 |
| Hohl BenjaminCHIEF FINANCIAL OFFICER | Sep 30, 2024 | Oct 1, 2024 | M | 2,000 | $2.48 | $4,960 | 2,000 | Yes | Form 4 |
| Hohl BenjaminCHIEF FINANCIAL OFFICER | Sep 30, 2024 | Oct 1, 2024 | S | 2,000 | $25.33 | Sale −$50,660 | not reported | Yes | Form 4 |
| Hohl BenjaminCHIEF FINANCIAL OFFICER | Sep 30, 2024 | Oct 1, 2024 | M · derivative | 2,000 | $2.48 | $4,960 | 192,879 | Yes | Form 4 |
| Hohl BenjaminCHIEF FINANCIAL OFFICER | Sep 27, 2024 | Oct 1, 2024 | M | 4,250 | $2.48 | $10,540 | 4,250 | Yes | Form 4 |
| Hohl BenjaminCHIEF FINANCIAL OFFICER | Sep 27, 2024 | Oct 1, 2024 | S | 4,250 | $24.27 | Sale −$103,148 | not reported | Yes | Form 4 |
| Hohl BenjaminCHIEF FINANCIAL OFFICER | Sep 27, 2024 | Oct 1, 2024 | M · derivative | 4,250 | $2.48 | $10,540 | 194,879 | Yes | Form 4 |
| Heyman Richard A. | Sep 16, 2024 | Sep 18, 2024 | S | 1,270 | $22.41 | Sale −$28,461 | 129,103 | Yes | Form 4 |
| Lyssikatos Joseph PCHIEF SCIENTIFIC OFFICER | Aug 29, 2024 | Sep 3, 2024 | S | 11,950 | $22.48 | Sale −$268,636 | 1,077,986 | Yes | Form 4 |
| Lyssikatos Joseph PCHIEF SCIENTIFIC OFFICER | Aug 29, 2024 | Sep 3, 2024 | S | 50 | $23.08 | Sale −$1,154 | 1,077,936 | Yes | Form 4 |
| Hohl BenjaminCHIEF FINANCIAL OFFICER | Aug 27, 2024 | Aug 29, 2024 | M | 4,250 | $2.48 | $10,540 | 4,250 | Yes | Form 4 |
| Hohl BenjaminCHIEF FINANCIAL OFFICER | Aug 27, 2024 | Aug 29, 2024 | S | 4,250 | $22.54 | Sale −$95,795 | not reported | Yes | Form 4 |
| Hohl BenjaminCHIEF FINANCIAL OFFICER | Aug 27, 2024 | Aug 29, 2024 | M · derivative | 4,250 | $2.48 | $10,540 | 199,129 | Yes | Form 4 |
| Kintz SamuelPRESIDENT AND CEO | Aug 26, 2024 | Aug 28, 2024 | S | 12,000 | $22.89 | Sale −$274,680 | 1,049,255 | Yes | Form 4 |
| Heyman Richard A. | Aug 15, 2024 | Aug 19, 2024 | S | 650 | $22.82 | Sale −$14,833 | 130,993 | Yes | Form 4 |
| Heyman Richard A. | Aug 15, 2024 | Aug 19, 2024 | S | 620 | $23.70 | Sale −$14,694 | 130,373 | Yes | Form 4 |
| Heyman Richard A. | Jul 31, 2024 | Aug 2, 2024 | S | 1,702 | $27.51 | Sale −$46,822 | 131,643 | Yes | Form 4 |
| Heyman Richard A. | Jul 31, 2024 | Aug 2, 2024 | S | 649 | $27.50 | Sale −$17,848 | 27,918 | Yes | Form 4 |
| Hohl BenjaminCHIEF FINANCIAL OFFICER | Jul 31, 2024 | Aug 2, 2024 | M | 991 | $2.48 | $2,458 | 991 | Yes | Form 4 |
| Hohl BenjaminCHIEF FINANCIAL OFFICER | Jul 31, 2024 | Aug 2, 2024 | S | 991 | $27.53 | Sale −$27,282 | not reported | Yes | Form 4 |
| Hohl BenjaminCHIEF FINANCIAL OFFICER | Jul 31, 2024 | Aug 2, 2024 | M · derivative | 991 | $2.48 | $2,458 | 203,379 | Yes | Form 4 |
| Kintz SamuelPRESIDENT AND CEO | Jul 31, 2024 | Aug 2, 2024 | S | 2,270 | $27.56 | Sale −$62,561 | 1,061,255 | Yes | Form 4 |
| Lyssikatos Joseph PCHIEF SCIENTIFIC OFFICER | Jul 31, 2024 | Aug 2, 2024 | S | 3,099 | $27.56 | Sale −$85,408 | 1,089,936 | Yes | Form 4 |
| Hohl BenjaminCHIEF FINANCIAL OFFICER | Jul 29, 2024 | Jul 31, 2024 | M | 5,250 | $2.48 | $13,020 | 5,250 | Yes | Form 4 |
| Hohl BenjaminCHIEF FINANCIAL OFFICER | Jul 29, 2024 | Jul 31, 2024 | S | 5,189 | $26.67 | Sale −$138,391 | 61 | Yes | Form 4 |
| Hohl BenjaminCHIEF FINANCIAL OFFICER | Jul 29, 2024 | Jul 31, 2024 | S | 61 | $27.44 | Sale −$1,674 | not reported | Yes | Form 4 |
| Hohl BenjaminCHIEF FINANCIAL OFFICER | Jul 29, 2024 | Jul 31, 2024 | M · derivative | 5,250 | $2.48 | $13,020 | 204,370 | Yes | Form 4 |
| Lyssikatos Joseph PCHIEF SCIENTIFIC OFFICER | Jul 29, 2024 | Jul 31, 2024 | S | 11,797 | $26.69 | Sale −$314,862 | 1,093,238 | Yes | Form 4 |
| Lyssikatos Joseph PCHIEF SCIENTIFIC OFFICER | Jul 29, 2024 | Jul 31, 2024 | S | 203 | $27.43 | Sale −$5,568 | 1,093,035 | Yes | Form 4 |
| Kintz SamuelPRESIDENT AND CEO | Jul 25, 2024 | Jul 29, 2024 | S | 3,793 | $24.53 | Sale −$93,042 | 1,071,732 | Yes | Form 4 |
| Kintz SamuelPRESIDENT AND CEO | Jul 25, 2024 | Jul 29, 2024 | S | 8,164 | $25.10 | Sale −$204,916 | 1,063,568 | Yes | Form 4 |
| Kintz SamuelPRESIDENT AND CEO | Jul 25, 2024 | Jul 29, 2024 | S | 43 | $25.83 | Sale −$1,111 | 1,063,525 | Yes | Form 4 |
| Heyman Richard A. | Jul 15, 2024 | Jul 17, 2024 | S | 1,270 | $24.80 | Sale −$31,496 | 133,345 | Yes | Form 4 |
| Patel AnishCHIEF OPERATING OFFICER | Jul 16, 2024 | Jul 16, 2024 | S | 1,547 | $25.01 | Sale −$38,690 | 344,027 | Yes | Form 4 |
| Patel AnishCHIEF OPERATING OFFICER | Jul 15, 2024 | Jul 16, 2024 | S | 30,978 | $25.05 | Sale −$775,999 | 345,574 | Yes | Form 4 |
| Hohl BenjaminCHIEF FINANCIAL OFFICER | Jul 12, 2024 | Jul 16, 2024 | M | 3,000 | $2.48 | $7,440 | 3,000 | Yes | Form 4 |
| Hohl BenjaminCHIEF FINANCIAL OFFICER | Jul 12, 2024 | Jul 16, 2024 | S | 3,000 | $25.07 | Sale −$75,210 | not reported | Yes | Form 4 |
| Hohl BenjaminCHIEF FINANCIAL OFFICER | Jul 12, 2024 | Jul 16, 2024 | M · derivative | 3,000 | $2.48 | $7,440 | 209,620 | Yes | Form 4 |
| Patel AnishCHIEF OPERATING OFFICER | Jul 12, 2024 | Jul 16, 2024 | S | 17,475 | $25.07 | Sale −$438,098 | 376,552 | Yes | Form 4 |
| Lyssikatos Joseph PCHIEF SCIENTIFIC OFFICER | Jul 1, 2024 | Jul 3, 2024 | S | 12,000 | $22.89 | Sale −$274,680 | 1,105,035 | Yes | Form 4 |
| Hohl BenjaminCHIEF FINANCIAL OFFICER | Jun 27, 2024 | Jul 1, 2024 | M | 4,250 | $2.48 | $10,540 | 4,250 | Yes | Form 4 |
| Hohl BenjaminCHIEF FINANCIAL OFFICER | Jun 27, 2024 | Jul 1, 2024 | S | 1,280 | $21.79 | Sale −$27,891 | 2,970 | Yes | Form 4 |
| Hohl BenjaminCHIEF FINANCIAL OFFICER | Jun 27, 2024 | Jul 1, 2024 | S | 1,830 | $22.58 | Sale −$41,321 | 1,140 | Yes | Form 4 |
| Hohl BenjaminCHIEF FINANCIAL OFFICER | Jun 27, 2024 | Jul 1, 2024 | S | 1,140 | $23.43 | Sale −$26,710 | not reported | Yes | Form 4 |
| Hohl BenjaminCHIEF FINANCIAL OFFICER | Jun 27, 2024 | Jul 1, 2024 | M · derivative | 4,250 | $2.48 | $10,540 | 212,620 | Yes | Form 4 |
| Kintz SamuelPRESIDENT AND CEO | Jun 25, 2024 | Jun 27, 2024 | S | 11,422 | $21.63 | Sale −$247,058 | 1,076,103 | Yes | Form 4 |
| Kintz SamuelPRESIDENT AND CEO | Jun 25, 2024 | Jun 27, 2024 | S | 578 | $22.30 | Sale −$12,889 | 1,075,525 | Yes | Form 4 |
| Heyman Richard A. | Jun 17, 2024 | Jun 20, 2024 | S | 1,270 | $21.48 | Sale −$27,280 | 134,615 | Yes | Form 4 |
| Patel AnishCHIEF OPERATING OFFICER | Jun 6, 2024 | Jun 10, 2024 | M | 1,133 | $2.48 | $2,810 | 1,133 | Yes | Form 4 |
| Patel AnishCHIEF OPERATING OFFICER | Jun 6, 2024 | Jun 10, 2024 | S | 1,133 | $20.06 | Sale −$22,728 | not reported | Yes | Form 4 |
| Patel AnishCHIEF OPERATING OFFICER | Jun 6, 2024 | Jun 10, 2024 | M · derivative | 1,133 | $2.48 | $2,810 | 53,342 | Yes | Form 4 |
| Lyssikatos Joseph PCHIEF SCIENTIFIC OFFICER | May 29, 2024 | May 31, 2024 | M | 12,000 | $1.12 | $13,440 | 12,000 | Yes | Form 4 |
| Lyssikatos Joseph PCHIEF SCIENTIFIC OFFICER | May 29, 2024 | May 31, 2024 | S | 9,877 | $21.56 | Sale −$212,948 | 2,123 | Yes | Form 4 |
| Lyssikatos Joseph PCHIEF SCIENTIFIC OFFICER | May 29, 2024 | May 31, 2024 | S | 2,123 | $22.52 | Sale −$47,810 | not reported | Yes | Form 4 |
| Lyssikatos Joseph PCHIEF SCIENTIFIC OFFICER | May 29, 2024 | May 31, 2024 | M · derivative | 12,000 | $1.12 | $13,440 | 206,550 | Yes | Form 4 |
| Hohl BenjaminCHIEF FINANCIAL OFFICER | May 28, 2024 | May 30, 2024 | M | 4,250 | $2.48 | $10,540 | 4,250 | Yes | Form 4 |
| Hohl BenjaminCHIEF FINANCIAL OFFICER | May 28, 2024 | May 30, 2024 | S | 1,906 | $22.89 | Sale −$43,628 | 2,344 | Yes | Form 4 |
| Hohl BenjaminCHIEF FINANCIAL OFFICER | May 28, 2024 | May 30, 2024 | S | 2,334 | $23.42 | Sale −$54,662 | 10 | Yes | Form 4 |
| Hohl BenjaminCHIEF FINANCIAL OFFICER | May 28, 2024 | May 30, 2024 | S | 10 | $24.34 | Sale −$243 | not reported | Yes | Form 4 |
| Hohl BenjaminCHIEF FINANCIAL OFFICER | May 28, 2024 | May 30, 2024 | M · derivative | 4,250 | $2.48 | $10,540 | 216,870 | Yes | Form 4 |
| Kintz SamuelPRESIDENT AND CEO | May 28, 2024 | May 30, 2024 | M | 12,000 | $1.12 | $13,440 | 12,000 | Yes | Form 4 |
| Kintz SamuelPRESIDENT AND CEO | May 28, 2024 | May 30, 2024 | S | 6,681 | $22.86 | Sale −$152,728 | 5,319 | Yes | Form 4 |
| Kintz SamuelPRESIDENT AND CEO | May 28, 2024 | May 30, 2024 | S | 5,219 | $23.57 | Sale −$123,012 | 100 | Yes | Form 4 |
| Kintz SamuelPRESIDENT AND CEO | May 28, 2024 | May 30, 2024 | S | 100 | $24.34 | Sale −$2,434 | not reported | Yes | Form 4 |
| Kintz SamuelPRESIDENT AND CEO | May 28, 2024 | May 30, 2024 | M · derivative | 12,000 | $1.12 | $13,440 | 188,841 | Yes | Form 4 |
| OrbiMed Capital GP VII LLC | May 16, 2024 | May 20, 2024 | S | 33,300 | $22.14 | Sale −$737,262 | 254,814 | No | Form 4 |
| OrbiMed Capital GP VII LLC | May 16, 2024 | May 20, 2024 | S | 1,000,000 | $22.14 | Sale −$22,140,000 | 7,663,349 | No | Form 4 |
| Gupta Rishi | May 16, 2024 | May 20, 2024 | S | 33,300 | $22.14 | Sale −$737,262 | 254,814 | No | Form 4 |
| Gupta Rishi | May 16, 2024 | May 20, 2024 | S | 1,000,000 | $22.14 | Sale −$22,140,000 | 7,663,349 | No | Form 4 |
| Heyman Richard A. | May 16, 2024 | May 20, 2024 | S | 1,270 | $23.74 | Sale −$30,150 | 135,885 | Yes | Form 4 |
| Patel AnishCHIEF OPERATING OFFICER | May 14, 2024 | May 16, 2024 | M | 1,107 | $2.48 | $2,745 | 1,107 | Yes | Form 4 |
| Patel AnishCHIEF OPERATING OFFICER | May 14, 2024 | May 16, 2024 | S | 1,107 | $25.00 | Sale −$27,675 | not reported | Yes | Form 4 |
| Patel AnishCHIEF OPERATING OFFICER | May 14, 2024 | May 16, 2024 | M · derivative | 1,107 | $2.48 | $2,745 | 54,475 | Yes | Form 4 |
| Patel AnishCHIEF OPERATING OFFICER | May 9, 2024 | May 13, 2024 | M | 260 | $2.48 | $645 | 260 | Yes | Form 4 |
| Patel AnishCHIEF OPERATING OFFICER | May 9, 2024 | May 13, 2024 | S | 260 | $25.06 | Sale −$6,516 | not reported | Yes | Form 4 |
| Patel AnishCHIEF OPERATING OFFICER | May 9, 2024 | May 13, 2024 | M · derivative | 260 | $2.48 | $645 | 55,582 | Yes | Form 4 |
| Patel AnishCHIEF OPERATING OFFICER | May 6, 2024 | May 8, 2024 | M | 4,875 | $2.48 | $12,090 | 4,875 | Yes | Form 4 |
| Patel AnishCHIEF OPERATING OFFICER | May 6, 2024 | May 8, 2024 | S | 4,875 | $22.72 | Sale −$110,760 | not reported | Yes | Form 4 |
| Patel AnishCHIEF OPERATING OFFICER | May 6, 2024 | May 8, 2024 | M · derivative | 4,875 | $2.48 | $12,090 | 55,842 | Yes | Form 4 |
| Hohl BenjaminCHIEF FINANCIAL OFFICER | May 3, 2024 | May 7, 2024 | M | 1,000 | $2.48 | $2,480 | 1,000 | Yes | Form 4 |
| Hohl BenjaminCHIEF FINANCIAL OFFICER | May 3, 2024 | May 7, 2024 | S | 1,000 | $22.50 | Sale −$22,500 | not reported | Yes | Form 4 |
| Hohl BenjaminCHIEF FINANCIAL OFFICER | May 3, 2024 | May 7, 2024 | M · derivative | 1,000 | $2.48 | $2,480 | 221,120 | Yes | Form 4 |
| Hohl BenjaminCHIEF FINANCIAL OFFICER | Apr 29, 2024 | May 1, 2024 | M | 3,250 | $2.48 | $8,060 | 3,250 | Yes | Form 4 |
| Hohl BenjaminCHIEF FINANCIAL OFFICER | Apr 29, 2024 | May 1, 2024 | S | 3,250 | $16.97 | Sale −$55,153 | not reported | Yes | Form 4 |
| Hohl BenjaminCHIEF FINANCIAL OFFICER | Apr 29, 2024 | May 1, 2024 | M · derivative | 3,250 | $2.48 | $8,060 | 222,120 | Yes | Form 4 |
| Lyssikatos Joseph PCHIEF SCIENTIFIC OFFICER | Apr 29, 2024 | May 1, 2024 | M | 12,000 | $1.12 | $13,440 | 12,000 | Yes | Form 4 |
| Lyssikatos Joseph PCHIEF SCIENTIFIC OFFICER | Apr 29, 2024 | May 1, 2024 | S | 10,987 | $17.86 | Sale −$196,228 | 1,013 | Yes | Form 4 |
| Lyssikatos Joseph PCHIEF SCIENTIFIC OFFICER | Apr 29, 2024 | May 1, 2024 | S | 1,013 | $18.48 | Sale −$18,720 | not reported | Yes | Form 4 |
| Lyssikatos Joseph PCHIEF SCIENTIFIC OFFICER | Apr 29, 2024 | May 1, 2024 | M · derivative | 12,000 | $1.12 | $13,440 | 218,550 | Yes | Form 4 |
| Kintz SamuelPRESIDENT AND CEO | Apr 25, 2024 | Apr 29, 2024 | M | 12,000 | $1.12 | $13,440 | 12,000 | Yes | Form 4 |
| Kintz SamuelPRESIDENT AND CEO | Apr 25, 2024 | Apr 29, 2024 | S | 12,000 | $16.89 | Sale −$202,680 | not reported | Yes | Form 4 |
| Kintz SamuelPRESIDENT AND CEO | Apr 25, 2024 | Apr 29, 2024 | M · derivative | 12,000 | $1.12 | $13,440 | 200,841 | Yes | Form 4 |
| Heyman Richard A. | Apr 15, 2024 | Apr 15, 2024 | S | 1,190 | $19.94 | Sale −$23,729 | 137,235 | Yes | Form 4 |
| Heyman Richard A. | Apr 15, 2024 | Apr 15, 2024 | S | 80 | $20.68 | Sale −$1,654 | 137,155 | Yes | Form 4 |
| Collins Helen LouiseCHIEF MEDICAL OFFICER | Apr 11, 2024 | Apr 15, 2024 | M | 20,000 | $2.48 | $49,600 | 20,000 | Yes | Form 4 |
| Collins Helen LouiseCHIEF MEDICAL OFFICER | Apr 11, 2024 | Apr 15, 2024 | S | 20,000 | $25.07 | Sale −$501,400 | not reported | Yes | Form 4 |
| Collins Helen LouiseCHIEF MEDICAL OFFICER | Apr 11, 2024 | Apr 15, 2024 | M · derivative | 20,000 | $2.48 | $49,600 | 267,084 | Yes | Form 4 |
| Heyman Richard A. | Apr 11, 2024 | Apr 15, 2024 | S | 5,045 | $25.03 | Sale −$126,276 | 138.43 | Yes | Form 4 |
| Heyman Richard A. | Apr 11, 2024 | Apr 15, 2024 | S | 649 | $25.00 | Sale −$16,225 | 28,567 | Yes | Form 4 |
| Hohl BenjaminCHIEF FINANCIAL OFFICER | Apr 11, 2024 | Apr 15, 2024 | M | 14,000 | $2.48 | $34,720 | 14,000 | Yes | Form 4 |
| Hohl BenjaminCHIEF FINANCIAL OFFICER | Apr 11, 2024 | Apr 15, 2024 | S | 3,777 | $23.88 | Sale −$90,195 | 10,223 | Yes | Form 4 |
| Hohl BenjaminCHIEF FINANCIAL OFFICER | Apr 11, 2024 | Apr 15, 2024 | S | 10,223 | $25.04 | Sale −$255,984 | not reported | Yes | Form 4 |
| Hohl BenjaminCHIEF FINANCIAL OFFICER | Apr 11, 2024 | Apr 15, 2024 | M · derivative | 14,000 | $2.48 | $34,720 | 225,370 | Yes | Form 4 |
| Kintz SamuelPRESIDENT AND CEO | Apr 11, 2024 | Apr 15, 2024 | M | 47,709 | $1.12 | $53,434 | 47,709 | Yes | Form 4 |
| Kintz SamuelPRESIDENT AND CEO | Apr 11, 2024 | Apr 15, 2024 | S | 47,709 | $25.04 | Sale −$1,194,633 | not reported | Yes | Form 4 |
| Kintz SamuelPRESIDENT AND CEO | Apr 11, 2024 | Apr 15, 2024 | M · derivative | 47,709 | $1.12 | $53,434 | 212,841 | Yes | Form 4 |
| Lyssikatos Joseph PCHIEF SCIENTIFIC OFFICER | Apr 11, 2024 | Apr 15, 2024 | M | 30,000 | $1.12 | $33,600 | 30,000 | Yes | Form 4 |
| Lyssikatos Joseph PCHIEF SCIENTIFIC OFFICER | Apr 11, 2024 | Apr 15, 2024 | S | 30,000 | $25.04 | Sale −$751,200 | not reported | Yes | Form 4 |
| Lyssikatos Joseph PCHIEF SCIENTIFIC OFFICER | Apr 11, 2024 | Apr 15, 2024 | M · derivative | 30,000 | $1.12 | $33,600 | 230,550 | Yes | Form 4 |
| Patel AnishCHIEF OPERATING OFFICER | Apr 11, 2024 | Apr 15, 2024 | M | 14,903 | $2.48 | $36,959 | 17,500 | Yes | Form 4 |
| Patel AnishCHIEF OPERATING OFFICER | Apr 11, 2024 | Apr 15, 2024 | S | 17,500 | $25.03 | Sale −$438,025 | not reported | Yes | Form 4 |
| Patel AnishCHIEF OPERATING OFFICER | Apr 11, 2024 | Apr 15, 2024 | M · derivative | 14,903 | $2.48 | $36,959 | 60,717 | Yes | Form 4 |
| Ballal Rahul D. | Apr 11, 2024 | Apr 12, 2024 | M | 48,820 | $12.60 | $615,132 | 71,161 | Yes | Form 4 |
| Ballal Rahul D. | Apr 11, 2024 | Apr 12, 2024 | M | 4,580 | $19.68 | $90,134 | 75,741 | Yes | Form 4 |
| Ballal Rahul D. | Apr 11, 2024 | Apr 12, 2024 | S | 30,300 | $23.14 | Sale −$701,142 | 45,441 | Yes | Form 4 |
| Ballal Rahul D. | Apr 11, 2024 | Apr 12, 2024 | S | 20,032 | $25.00 | Sale −$500,800 | 25,409 | Yes | Form 4 |
| Ballal Rahul D. | Apr 11, 2024 | Apr 12, 2024 | S | 3,068 | $25.21 | Sale −$77,344 | 22,341 | Yes | Form 4 |
| Ballal Rahul D. | Apr 11, 2024 | Apr 12, 2024 | M · derivative | 48,820 | $12.60 | $615,132 | not reported | Yes | Form 4 |
| Ballal Rahul D. | Apr 11, 2024 | Apr 12, 2024 | M · derivative | 4,580 | $19.68 | $90,134 | 75,742 | Yes | Form 4 |
| Ballal Rahul D. | Apr 10, 2024 | Apr 12, 2024 | M | 13,600 | $12.60 | $171,360 | 35,941 | Yes | Form 4 |
| Ballal Rahul D. | Apr 10, 2024 | Apr 12, 2024 | S | 13,600 | $21.01 | Sale −$285,736 | 22,341 | Yes | Form 4 |
| Ballal Rahul D. | Apr 10, 2024 | Apr 12, 2024 | M · derivative | 13,600 | $12.60 | $171,360 | 48,820 | Yes | Form 4 |
| Patel AnishCHIEF OPERATING OFFICER | Apr 8, 2024 | Apr 10, 2024 | S | 4,331 | $18.50 | Sale −$80,124 | 3,141 | Yes | Form 4 |
| Patel AnishCHIEF OPERATING OFFICER | Apr 8, 2024 | Apr 10, 2024 | S | 544 | $19.40 | Sale −$10,554 | 2,597 | Yes | Form 4 |
| Kunkel Lori Anne | Apr 8, 2024 | Apr 10, 2024 | A · derivative | 37,882 | $18.30 | $693,241 | 37,882 | No | Form 4 |
| Ballal Rahul D. | Apr 4, 2024 | Apr 8, 2024 | M | 3,485 | $12.60 | $43,911 | 25,826 | Yes | Form 4 |
| Ballal Rahul D. | Apr 4, 2024 | Apr 8, 2024 | S | 3,485 | $19.15 | Sale −$66,738 | 22,341 | Yes | Form 4 |
| Ballal Rahul D. | Apr 4, 2024 | Apr 8, 2024 | M · derivative | 3,485 | $12.60 | $43,911 | 62,420 | Yes | Form 4 |
| Lyssikatos Joseph PCHIEF SCIENTIFIC OFFICER | Apr 1, 2024 | Apr 3, 2024 | M | 12,000 | $1.12 | $13,440 | 12,000 | Yes | Form 4 |
| Lyssikatos Joseph PCHIEF SCIENTIFIC OFFICER | Apr 1, 2024 | Apr 3, 2024 | S | 2,352 | $17.72 | Sale −$41,677 | 9,648 | Yes | Form 4 |
| Lyssikatos Joseph PCHIEF SCIENTIFIC OFFICER | Apr 1, 2024 | Apr 3, 2024 | S | 9,577 | $18.80 | Sale −$180,048 | 71 | Yes | Form 4 |
| Lyssikatos Joseph PCHIEF SCIENTIFIC OFFICER | Apr 1, 2024 | Apr 3, 2024 | S | 71 | $19.36 | Sale −$1,375 | not reported | Yes | Form 4 |
| Lyssikatos Joseph PCHIEF SCIENTIFIC OFFICER | Apr 1, 2024 | Apr 3, 2024 | M · derivative | 12,000 | $1.12 | $13,440 | 260,550 | Yes | Form 4 |
| Ballal Rahul D. | Apr 1, 2024 | Apr 3, 2024 | M | 94 | $12.60 | $1,184 | 22,435 | Yes | Form 4 |
| Ballal Rahul D. | Apr 1, 2024 | Apr 3, 2024 | M | 3,143 | $5.52 | $17,349 | 25,578 | Yes | Form 4 |
| Ballal Rahul D. | Apr 1, 2024 | Apr 3, 2024 | S | 3,237 | $19.08 | Sale −$61,762 | 22,341 | Yes | Form 4 |
| Ballal Rahul D. | Apr 1, 2024 | Apr 3, 2024 | M · derivative | 94 | $12.60 | $1,184 | 65,905 | Yes | Form 4 |
| Ballal Rahul D. | Apr 1, 2024 | Apr 3, 2024 | M · derivative | 3,143 | $5.52 | $17,349 | 16,428 | Yes | Form 4 |
| Hohl BenjaminCHIEF FINANCIAL OFFICER | Mar 27, 2024 | Mar 29, 2024 | M | 3,250 | $2.48 | $8,060 | 3,250 | Yes | Form 4 |
| Hohl BenjaminCHIEF FINANCIAL OFFICER | Mar 27, 2024 | Mar 29, 2024 | S | 3,068 | $18.22 | Sale −$55,899 | 182 | Yes | Form 4 |
| Hohl BenjaminCHIEF FINANCIAL OFFICER | Mar 27, 2024 | Mar 29, 2024 | S | 182 | $18.72 | Sale −$3,407 | not reported | Yes | Form 4 |
| Hohl BenjaminCHIEF FINANCIAL OFFICER | Mar 27, 2024 | Mar 29, 2024 | M · derivative | 3,250 | $2.48 | $8,060 | 239,370 | Yes | Form 4 |
| Kintz SamuelPRESIDENT AND CEO | Mar 25, 2024 | Mar 27, 2024 | M | 12,000 | $1.12 | $13,440 | 12,000 | Yes | Form 4 |
| Kintz SamuelPRESIDENT AND CEO | Mar 25, 2024 | Mar 27, 2024 | S | 7,329 | $17.17 | Sale −$125,839 | 4,671 | Yes | Form 4 |
| Kintz SamuelPRESIDENT AND CEO | Mar 25, 2024 | Mar 27, 2024 | S | 4,671 | $18.16 | Sale −$84,825 | not reported | Yes | Form 4 |
| Kintz SamuelPRESIDENT AND CEO | Mar 25, 2024 | Mar 27, 2024 | M · derivative | 12,000 | $1.12 | $13,440 | 260,550 | Yes | Form 4 |
| Ballal Rahul D. | Mar 20, 2024 | Mar 22, 2024 | M | 13,278 | $5.52 | $73,295 | 35,619 | Yes | Form 4 |
| Ballal Rahul D. | Mar 20, 2024 | Mar 22, 2024 | S | 13,278 | $19.16 | Sale −$254,406 | 22,341 | Yes | Form 4 |
| Ballal Rahul D. | Mar 20, 2024 | Mar 22, 2024 | M · derivative | 13,278 | $5.52 | $73,295 | 19,571 | Yes | Form 4 |
| Heyman Richard A. | Mar 19, 2024 | Mar 21, 2024 | S | 1,270 | $14.50 | Sale −$18,415 | 143,470 | Yes | Form 4 |
| Patel AnishCHIEF OPERATING OFFICER | Mar 6, 2024 | Mar 8, 2024 | S | 4,875 | $15.64 | Sale −$76,245 | 7,472 | Yes | Form 4 |
| Lyssikatos Joseph PCHIEF SCIENTIFIC OFFICER | Feb 29, 2024 | Mar 4, 2024 | M | 12,000 | $1.12 | $13,440 | 12,000 | Yes | Form 4 |
| Lyssikatos Joseph PCHIEF SCIENTIFIC OFFICER | Feb 29, 2024 | Mar 4, 2024 | S | 10,195 | $16.30 | Sale −$166,179 | 1,805 | Yes | Form 4 |
| Lyssikatos Joseph PCHIEF SCIENTIFIC OFFICER | Feb 29, 2024 | Mar 4, 2024 | S | 1,805 | $17.09 | Sale −$30,847 | not reported | Yes | Form 4 |
| Lyssikatos Joseph PCHIEF SCIENTIFIC OFFICER | Feb 29, 2024 | Mar 4, 2024 | M · derivative | 12,000 | $1.12 | $13,440 | 272,550 | Yes | Form 4 |
| Hohl BenjaminCHIEF FINANCIAL OFFICER | Feb 27, 2024 | Feb 29, 2024 | M | 3,250 | $2.48 | $8,060 | 3,250 | Yes | Form 4 |
| Hohl BenjaminCHIEF FINANCIAL OFFICER | Feb 27, 2024 | Feb 29, 2024 | S | 3,250 | $16.97 | Sale −$55,153 | not reported | Yes | Form 4 |
| Hohl BenjaminCHIEF FINANCIAL OFFICER | Feb 27, 2024 | Feb 29, 2024 | M · derivative | 3,250 | $2.48 | $8,060 | 242,620 | Yes | Form 4 |
| Kintz SamuelPRESIDENT AND CEO | Feb 26, 2024 | Feb 28, 2024 | M | 12,000 | $1.12 | $13,440 | 12,000 | Yes | Form 4 |
| Kintz SamuelPRESIDENT AND CEO | Feb 26, 2024 | Feb 28, 2024 | S | 7,624 | $16.69 | Sale −$127,245 | 4,376 | Yes | Form 4 |
| Kintz SamuelPRESIDENT AND CEO | Feb 26, 2024 | Feb 28, 2024 | S | 4,376 | $17.24 | Sale −$75,442 | not reported | Yes | Form 4 |
| Kintz SamuelPRESIDENT AND CEO | Feb 26, 2024 | Feb 28, 2024 | M · derivative | 12,000 | $1.12 | $13,440 | 272,550 | Yes | Form 4 |
| Heyman Richard A. | Feb 15, 2024 | Feb 20, 2024 | S | 1,270 | $17.42 | Sale −$22,123 | 144,740 | Yes | Form 4 |
| Ballal Rahul D. | Feb 13, 2024 | Feb 20, 20244/A | A · derivative | 23,364 | $14.85 | $346,955 | 23,364 | No | Form 4/A |
| Bauer Jake | Feb 13, 2024 | Feb 20, 20244/A | A · derivative | 23,364 | $14.85 | $346,955 | 23,364 | No | Form 4/A |
| Derynck Mika K | Feb 13, 2024 | Feb 20, 20244/A | A · derivative | 23,364 | $14.85 | $346,955 | 23,364 | No | Form 4/A |
| Gupta Rishi | Feb 13, 2024 | Feb 20, 20244/A | A · derivative | 23,364 | $14.85 | $346,955 | 23,364 | No | Form 4/A |
| Heyman Richard A. | Feb 13, 2024 | Feb 20, 20244/A | A · derivative | 29,205 | $14.85 | $433,694 | 29,205 | No | Form 4/A |
| Phillips Andrew John | Feb 13, 2024 | Feb 20, 20244/A | A · derivative | 23,364 | $14.85 | $346,955 | 23,364 | No | Form 4/A |
| 5AM Ventures VI, L.P. | Feb 14, 2024 | Feb 16, 2024 | S | 688,358 | $14.90 | Sale −$10,256,534 | 3,200,634 | No | Form 4 |
| 5AM Ventures VI, L.P. | Feb 14, 2024 | Feb 16, 2024 | S | 136,642 | $14.90 | Sale −$2,035,966 | 635,341 | No | Form 4 |
| Collins Helen LouiseCHIEF MEDICAL OFFICER | Feb 13, 2024 | Feb 15, 2024 | A · derivative | 185,000 | $14.85 | $2,747,250 | 185,000 | No | Form 4 |
| Hohl BenjaminCHIEF FINANCIAL OFFICER | Feb 13, 2024 | Feb 15, 2024 | A · derivative | 185,000 | $14.85 | $2,747,250 | 185,000 | No | Form 4 |
| Kintz SamuelPRESIDENT AND CEO | Feb 13, 2024 | Feb 15, 2024 | A · derivative | 410,000 | $14.85 | $6,088,500 | 410,000 | No | Form 4 |
| Lyssikatos Joseph PCHIEF SCIENTIFIC OFFICER | Feb 13, 2024 | Feb 15, 2024 | A · derivative | 185,000 | $14.85 | $2,747,250 | 185,000 | No | Form 4 |
| Patel AnishCHIEF OPERATING OFFICER | Feb 13, 2024 | Feb 15, 2024 | A · derivative | 185,000 | $14.85 | $2,747,250 | 185,000 | No | Form 4 |
| Patel AnishCHIEF OPERATING OFFICER | Feb 6, 2024 | Feb 8, 2024 | S | 4,875 | $15.11 | Sale −$73,661 | 12,347 | Yes | Form 4 |
| 5AM Opportunities I (GP), LLC | Jan 31, 2024 | Feb 2, 2024 | S | 417,187 | $15.00 | Sale −$6,257,805 | 3,888,992 | No | Form 4 |
| 5AM Opportunities I (GP), LLC | Jan 31, 2024 | Feb 2, 2024 | S | 82,813 | $15.00 | Sale −$1,242,195 | 771,983 | No | Form 4 |
| Heyman Richard A. | Jan 30, 2024 | Feb 1, 2024 | S | 1,270 | $16.41 | Sale −$20,841 | 146,010 | Yes | Form 4 |
| Hohl BenjaminCHIEF FINANCIAL OFFICER | Jan 29, 2024 | Jan 31, 2024 | M | 3,250 | $2.48 | $8,060 | 3,250 | Yes | Form 4 |
| Hohl BenjaminCHIEF FINANCIAL OFFICER | Jan 29, 2024 | Jan 31, 2024 | S | 3,250 | $15.81 | Sale −$51,383 | not reported | Yes | Form 4 |
| Hohl BenjaminCHIEF FINANCIAL OFFICER | Jan 29, 2024 | Jan 31, 2024 | M · derivative | 3,250 | $2.48 | $8,060 | 245,870 | Yes | Form 4 |