EWTXEdgewise Therapeutics, Inc.
- Market cap
- $4.27B
- as of 2026-10-23
- Latest close
- $39.31
- as of 2026-10-23
- Sector
- Healthcare
- as of 2026-10-24
- Industry
- Biotechnology
- as of 2026-10-24
Cluster
No cluster in the last 90 days under the default rule (14d · ≥2 insiders · all roles).
Form 4 historysince 2023-12-28
Dashed line = amended filing (Form 4/A)
| Insider | Traded | Filed | Type | Shares | Price | Value | Owned after | 10b5-1 plan | Filing |
|---|---|---|---|---|---|---|---|---|---|
| Fox Jonathan C | Oct 1 | Oct 2 | A | 308 | $0.00 | $0 | 25,141 | No | Form 4 |
| Moore John RGeneral Counsel | Aug 12 | Aug 174/A | A · derivative | 65,000 | $43.56 | $2,831,400 | 65,000 | No | Form 4/A |
| Donovan Joanne M.CMO | Aug 12 | Aug 174/A | A · derivative | 65,000 | $43.56 | $2,831,400 | 65,000 | No | Form 4/A |
| Nofi MichaelChief Financial Officer | Aug 12 | Aug 174/A | A · derivative | 48,750 | $43.56 | $2,123,550 | 48,750 | No | Form 4/A |
| Derakhshan BehradChief Business Officer | Aug 12 | Aug 174/A | A · derivative | 100,000 | $43.56 | $4,356,000 | 100,000 | No | Form 4/A |
| Russell Alan JChief Scientific Officer | Aug 12 | Aug 174/A | A · derivative | 65,000 | $43.56 | $2,831,400 | 65,000 | No | Form 4/A |
| Koch KevinPresident and CEO | Aug 12 | Aug 14 | M | 17,969 | $0.00 | $0 | 48,584 | No | Form 4 |
| Koch KevinPresident and CEO | Aug 12 | Aug 14 | M | 21,875 | $0.00 | $0 | 70,459 | No | Form 4 |
| Koch KevinPresident and CEO | Aug 12 | Aug 14 | S | 8,782 | $43.64 | Sale −$383,246 | 61,677 | No | Form 4 |
| Koch KevinPresident and CEO | Aug 12 | Aug 14 | S | 8,276 | $43.66 | Sale −$361,330 | 53,401 | No | Form 4 |
| Koch KevinPresident and CEO | Aug 12 | Aug 14 | S | 913 | $44.33 | Sale −$40,473 | 52,488 | No | Form 4 |
| Koch KevinPresident and CEO | Aug 12 | Aug 14 | M · derivative | 17,969 | $0.00 | $0 | 35,938 | No | Form 4 |
| Koch KevinPresident and CEO | Aug 12 | Aug 14 | M · derivative | 21,875 | $0.00 | $0 | 65,625 | No | Form 4 |
| Koch KevinPresident and CEO | Aug 12 | Aug 14 | A · derivative | 100,000 | $0.00 | $0 | 100,000 | No | Form 4 |
| Koch KevinPresident and CEO | Aug 12 | Aug 14 | A · derivative | 200,000 | $43.56 | $8,712,000 | 200,000 | No | Form 4 |
| Root Jonathan D | Jun 5 | Jul 17 | A · derivative | 16,377 | $35.59 | $582,857 | 16,377 | No | Form 4 |
| Russell Alan JChief Scientific Officer | Jul 1 | Jul 2 | M | 130,352 | $0.45 | $58,658 | 154,907 | Yes | Form 4 |
| Russell Alan JChief Scientific Officer | Jul 1 | Jul 2 | M | 69,648 | $0.18 | $12,537 | 224,555 | Yes | Form 4 |
| Russell Alan JChief Scientific Officer | Jul 1 | Jul 2 | S | 130,352 | $39.41 | Sale −$5,137,172 | 94,203 | Yes | Form 4 |
| Russell Alan JChief Scientific Officer | Jul 1 | Jul 2 | S | 69,648 | $39.41 | Sale −$2,744,828 | 24,555 | Yes | Form 4 |
| Russell Alan JChief Scientific Officer | Jul 1 | Jul 2 | M · derivative | 130,352 | $0.45 | $58,658 | not reported | Yes | Form 4 |
| Russell Alan JChief Scientific Officer | Jul 1 | Jul 2 | M · derivative | 69,648 | $0.18 | $12,537 | 1,077,717 | Yes | Form 4 |
| Fox Jonathan C | Jul 1 | Jul 1 | A | 319 | $0.00 | $0 | 24,833 | No | Form 4 |
| Thompson Peter A. | Jun 5 | Jun 17 | A · derivative | 16,377 | $35.59 | $582,857 | 16,377 | No | Form 4 |
| Morris Arlene | Jun 5 | Jun 17 | A · derivative | 16,377 | $35.59 | $582,857 | 16,377 | No | Form 4 |
| Brege Laura | Jun 5 | Jun 17 | A · derivative | 16,377 | $35.59 | $582,857 | 16,377 | No | Form 4 |
| Fox Jonathan C | Jun 5 | Jun 16 | A · derivative | 16,377 | $35.59 | $582,857 | 16,377 | No | Form 4 |
| Edris Badreddin | Jun 5 | Jun 16 | A · derivative | 5,619 | $0.00 | $0 | 5,619 | No | Form 4 |
| Edris Badreddin | Jun 5 | Jun 16 | A · derivative | 8,188 | $35.59 | $291,411 | 8,188 | No | Form 4 |
| Martin Christopher Nathan | Jun 5 | Jun 16 | A · derivative | 16,377 | $35.59 | $582,857 | 16,377 | No | Form 4 |
| Donovan Joanne M.CMO | May 5 | May 5 | M | 50,000 | $7.08 | $354,000 | 54,367 | No | Form 4 |
| Donovan Joanne M.CMO | May 5 | May 5 | S | 50,000 | $38.57 | Sale −$1,928,500 | 4,367 | No | Form 4 |
| Donovan Joanne M.CMO | May 5 | May 5 | M · derivative | 50,000 | $7.08 | $354,000 | 75,000 | No | Form 4 |
| Donovan Joanne M.CMO | May 4 | May 5 | S | 5,230 | $31.29 | Sale −$163,647 | 4,367 | No | Form 4 |
| Fox Jonathan C | Apr 1 | Apr 3 | A | 339 | $0.00 | $0 | 24,514 | No | Form 4 |
| Donovan Joanne M.CMO | Apr 1 | Apr 2 | M | 28,662 | $7.08 | $202,927 | 38,259 | Yes | Form 4 |
| Donovan Joanne M.CMO | Apr 1 | Apr 2 | S | 28,662 | $32.31 | Sale −$926,069 | 9,597 | Yes | Form 4 |
| Donovan Joanne M.CMO | Apr 1 | Apr 2 | M · derivative | 28,662 | $7.08 | $202,927 | 125,000 | Yes | Form 4 |
| Donovan Joanne M.CMO | Mar 31 | Mar 31 | M | 21,338 | $7.08 | $151,073 | 30,935 | Yes | Form 4 |
| Donovan Joanne M.CMO | Mar 31 | Mar 31 | S | 21,338 | $32.12 | Sale −$685,377 | 9,597 | Yes | Form 4 |
| Donovan Joanne M.CMO | Mar 31 | Mar 31 | M · derivative | 21,338 | $7.08 | $151,073 | 153,662 | Yes | Form 4 |
| Donovan Joanne M.CMO | Mar 27 | Mar 30 | S | 9,623 | $30.98 | Sale −$298,121 | 16,332 | Yes | Form 4 |
| Donovan Joanne M.CMO | Mar 27 | Mar 30 | S | 6,735 | $30.98 | Sale −$208,650 | 9,597 | Yes | Form 4 |
| Edris Badreddin | Jan 21 | Jan 23 | M | 13,690 | $0.39 | $5,339 | 33,510 | Yes | Form 4 |
| Edris Badreddin | Jan 21 | Jan 23 | M | 17,236 | $0.64 | $11,031 | 50,746 | Yes | Form 4 |
| Edris Badreddin | Jan 21 | Jan 23 | M | 10,463 | $1.93 | $20,194 | 61,209 | Yes | Form 4 |
| Edris Badreddin | Jan 21 | Jan 23 | M | 66,477 | $1.93 | $128,301 | 127,686 | Yes | Form 4 |
| Edris Badreddin | Jan 21 | Jan 23 | M | 7,605 | $0.71 | $5,400 | 135,291 | Yes | Form 4 |
| Edris Badreddin | Jan 21 | Jan 23 | S | 13,690 | $29.44 | Sale −$403,034 | 121,601 | Yes | Form 4 |
| Edris Badreddin | Jan 21 | Jan 23 | S | 17,236 | $29.44 | Sale −$507,428 | 104,365 | Yes | Form 4 |
| Edris Badreddin | Jan 21 | Jan 23 | S | 7,605 | $29.44 | Sale −$223,891 | 96,760 | Yes | Form 4 |
| Edris Badreddin | Jan 21 | Jan 23 | S | 10,463 | $29.44 | Sale −$308,031 | 86,297 | Yes | Form 4 |
| Edris Badreddin | Jan 21 | Jan 23 | S | 66,477 | $29.44 | Sale −$1,957,083 | 19,820 | Yes | Form 4 |
| Edris Badreddin | Jan 21 | Jan 23 | M · derivative | 10,463 | $1.93 | $20,194 | not reported | Yes | Form 4 |
| Edris Badreddin | Jan 21 | Jan 23 | M · derivative | 66,477 | $1.93 | $128,301 | not reported | Yes | Form 4 |
| Edris Badreddin | Jan 21 | Jan 23 | M · derivative | 7,605 | $0.71 | $5,400 | not reported | Yes | Form 4 |
| Edris Badreddin | Jan 21 | Jan 23 | M · derivative | 17,236 | $0.64 | $11,031 | not reported | Yes | Form 4 |
| Edris Badreddin | Jan 21 | Jan 23 | M · derivative | 13,690 | $0.39 | $5,339 | not reported | Yes | Form 4 |
| Fox Jonathan C | Jan 2 | Jan 5 | A | 473 | $0.00 | $0 | 24,175 | No | Form 4 |
| Martin Christopher Nathan | Nov 19, 2025 | Nov 24, 2025 | A · derivative | 45,150 | $22.34 | $1,008,651 | 45,150 | No | Form 4 |
| Russell Alan JChief Scientific Officer | Nov 12, 2025 | Nov 13, 2025 | M | 100,000 | $0.18 | $18,000 | 123,400 | No | Form 4 |
| Russell Alan JChief Scientific Officer | Nov 12, 2025 | Nov 13, 2025 | S | 100,000 | $21.12 | Sale −$2,112,000 | 23,400 | No | Form 4 |
| Russell Alan JChief Scientific Officer | Nov 12, 2025 | Nov 13, 2025 | M · derivative | 100,000 | $0.18 | $18,000 | 1,147,365 | No | Form 4 |
| Fox Jonathan C | Nov 11, 2025 | Nov 13, 2025 | P | 10,700 | $18.64 | Purchase +$199,448 | 23,702 | No | Form 4 |
| Nofi MichaelChief Financial Officer | Nov 10, 2025 | Nov 13, 2025 | A · derivative | 43,750 | $0.00 | $0 | 43,750 | No | Form 4 |
| Nofi MichaelChief Financial Officer | Nov 10, 2025 | Nov 13, 2025 | A · derivative | 262,500 | $18.28 | $4,798,500 | 262,500 | No | Form 4 |
| Fox Jonathan C | Oct 1, 2025 | Oct 2, 2025 | A | 728 | $0.00 | $0 | 13,002 | No | Form 4 |
| Russell Alan JChief Scientific Officer | Aug 26, 2025 | Aug 28, 2025 | M | 100,000 | $0.18 | $18,000 | 123,400 | No | Form 4 |
| Russell Alan JChief Scientific Officer | Aug 26, 2025 | Aug 28, 2025 | S | 100,000 | $14.60 | Sale −$1,460,000 | 23,400 | No | Form 4 |
| Russell Alan JChief Scientific Officer | Aug 26, 2025 | Aug 28, 2025 | M · derivative | 100,000 | $0.18 | $18,000 | 1,247,365 | No | Form 4 |
| Donovan Joanne M.CMO | Aug 12, 2025 | Aug 14, 2025 | M | 5,781 | $0.00 | $0 | 28,223 | No | Form 4 |
| Donovan Joanne M.CMO | Aug 12, 2025 | Aug 14, 2025 | S | 2,862 | $13.39 | Sale −$38,322 | 25,361 | No | Form 4 |
| Donovan Joanne M.CMO | Aug 12, 2025 | Aug 14, 2025 | M · derivative | 5,781 | $0.00 | $0 | 17,344 | No | Form 4 |
| Donovan Joanne M.CMO | Aug 12, 2025 | Aug 14, 2025 | A · derivative | 28,125 | $0.00 | $0 | 28,125 | No | Form 4 |
| Donovan Joanne M.CMO | Aug 12, 2025 | Aug 14, 2025 | A · derivative | 168,750 | $13.39 | $2,259,563 | 168,750 | No | Form 4 |
| Koch KevinPresident and CEO | Aug 12, 2025 | Aug 14, 2025 | M | 17,968 | $0.00 | $0 | 38,587 | No | Form 4 |
| Koch KevinPresident and CEO | Aug 12, 2025 | Aug 14, 2025 | S | 7,972 | $13.39 | Sale −$106,745 | 30,615 | No | Form 4 |
| Koch KevinPresident and CEO | Aug 12, 2025 | Aug 14, 2025 | M · derivative | 17,968 | $0.00 | $0 | 53,907 | No | Form 4 |
| Koch KevinPresident and CEO | Aug 12, 2025 | Aug 14, 2025 | A · derivative | 87,500 | $0.00 | $0 | 87,500 | No | Form 4 |
| Koch KevinPresident and CEO | Aug 12, 2025 | Aug 14, 2025 | A · derivative | 525,000 | $13.39 | $7,029,750 | 525,000 | No | Form 4 |
| Russell Alan JChief Scientific Officer | Aug 12, 2025 | Aug 14, 2025 | M | 5,781 | $0.00 | $0 | 25,307 | No | Form 4 |
| Russell Alan JChief Scientific Officer | Aug 12, 2025 | Aug 14, 2025 | S | 1,907 | $13.39 | Sale −$25,535 | 23,400 | No | Form 4 |
| Russell Alan JChief Scientific Officer | Aug 12, 2025 | Aug 14, 2025 | M · derivative | 5,781 | $0.00 | $0 | 17,344 | No | Form 4 |
| Russell Alan JChief Scientific Officer | Aug 12, 2025 | Aug 14, 2025 | A · derivative | 28,125 | $0.00 | $0 | 28,125 | No | Form 4 |
| Russell Alan JChief Scientific Officer | Aug 12, 2025 | Aug 14, 2025 | A · derivative | 168,750 | $13.39 | $2,259,563 | 168,750 | No | Form 4 |
| Carruthers R MichaelChief Financial Officer | Aug 12, 2025 | Aug 14, 2025 | M | 5,781 | $0.00 | $0 | 87,590 | No | Form 4 |
| Carruthers R MichaelChief Financial Officer | Aug 12, 2025 | Aug 14, 2025 | S | 1,428 | $13.39 | Sale −$19,121 | 86,162 | No | Form 4 |
| Carruthers R MichaelChief Financial Officer | Aug 12, 2025 | Aug 14, 2025 | M · derivative | 5,781 | $0.00 | $0 | 17,344 | No | Form 4 |
| Carruthers R MichaelChief Financial Officer | Aug 12, 2025 | Aug 14, 2025 | A · derivative | 26,875 | $0.00 | $0 | 26,875 | No | Form 4 |
| Carruthers R MichaelChief Financial Officer | Aug 12, 2025 | Aug 14, 2025 | A · derivative | 161,250 | $13.39 | $2,159,138 | 161,250 | No | Form 4 |
| Derakhshan BehradChief Business Officer | Aug 12, 2025 | Aug 14, 2025 | M | 5,781 | $0.00 | $0 | 26,136 | No | Form 4 |
| Derakhshan BehradChief Business Officer | Aug 12, 2025 | Aug 14, 2025 | S | 2,491 | $13.39 | Sale −$33,354 | 23,645 | No | Form 4 |
| Derakhshan BehradChief Business Officer | Aug 12, 2025 | Aug 14, 2025 | M · derivative | 5,781 | $0.00 | $0 | 17,344 | No | Form 4 |
| Derakhshan BehradChief Business Officer | Aug 12, 2025 | Aug 14, 2025 | A · derivative | 30,000 | $0.00 | $0 | 30,000 | No | Form 4 |
| Derakhshan BehradChief Business Officer | Aug 12, 2025 | Aug 14, 2025 | A · derivative | 180,000 | $13.39 | $2,410,200 | 180,000 | No | Form 4 |
| Moore John RGeneral Counsel | Aug 12, 2025 | Aug 14, 2025 | M | 5,781 | $0.00 | $0 | 12,312 | No | Form 4 |
| Moore John RGeneral Counsel | Aug 12, 2025 | Aug 14, 2025 | S | 2,098 | $13.39 | Sale −$28,092 | 10,214 | No | Form 4 |
| Moore John RGeneral Counsel | Aug 12, 2025 | Aug 14, 2025 | M · derivative | 5,781 | $0.00 | $0 | 17,344 | No | Form 4 |
| Moore John RGeneral Counsel | Aug 12, 2025 | Aug 14, 2025 | A · derivative | 26,875 | $0.00 | $0 | 26,875 | No | Form 4 |
| Moore John RGeneral Counsel | Aug 12, 2025 | Aug 14, 2025 | A · derivative | 161,250 | $13.39 | $2,159,138 | 161,250 | No | Form 4 |
| Blaustein RobertChief Development Officer | Aug 12, 2025 | Aug 14, 2025 | A · derivative | 17,500 | $0.00 | $0 | 17,500 | No | Form 4 |
| Blaustein RobertChief Development Officer | Aug 12, 2025 | Aug 14, 2025 | A · derivative | 105,000 | $13.39 | $1,405,950 | 105,000 | No | Form 4 |
| Fox Jonathan C | Jul 1, 2025 | Jul 2, 2025 | A | 858 | $0.00 | $0 | 12,274 | No | Form 4 |
| Thompson Peter A. | Jun 16, 2025 | Jun 18, 2025 | A · derivative | 30,000 | $14.68 | $440,400 | 30,000 | No | Form 4 |
| Root Jonathan D | Jun 16, 2025 | Jun 18, 2025 | A · derivative | 30,000 | $14.68 | $440,400 | 30,000 | No | Form 4 |
| Morris Arlene | Jun 16, 2025 | Jun 18, 2025 | A · derivative | 30,000 | $14.68 | $440,400 | 30,000 | No | Form 4 |
| Fox Jonathan C | Jun 16, 2025 | Jun 18, 2025 | A · derivative | 30,000 | $14.68 | $440,400 | 30,000 | No | Form 4 |
| Edris Badreddin | Jun 16, 2025 | Jun 18, 2025 | A · derivative | 30,000 | $14.68 | $440,400 | 30,000 | No | Form 4 |
| Brege Laura | Jun 16, 2025 | Jun 18, 2025 | A · derivative | 30,000 | $14.68 | $440,400 | 30,000 | No | Form 4 |
| Carruthers R MichaelChief Financial Officer | May 2, 2025 | May 7, 2025 | S | 1,314 | $16.45 | Sale −$21,615 | 81,014 | No | Form 4 |
| Derakhshan BehradChief Business Officer | May 2, 2025 | May 7, 2025 | S | 1,691 | $16.45 | Sale −$27,817 | 20,355 | No | Form 4 |
| Donovan Joanne M.CMO | May 2, 2025 | May 7, 2025 | S | 5,187 | $16.45 | Sale −$85,326 | 21,588 | No | Form 4 |
| Koch KevinPresident and CEO | May 2, 2025 | May 7, 2025 | S | 4,276 | $16.45 | Sale −$70,340 | 20,619 | No | Form 4 |
| Moore John RGeneral Counsel | May 2, 2025 | May 7, 2025 | S | 1,930 | $16.45 | Sale −$31,749 | 6,531 | No | Form 4 |
| Russell Alan JChief Scientific Officer | May 2, 2025 | May 7, 2025 | S | 1,551 | $16.45 | Sale −$25,514 | 18,521 | No | Form 4 |
| Carruthers R MichaelChief Financial Officer | May 1, 2025 | May 7, 2025 | M | 5,209 | $0.00 | $0 | 82,328 | No | Form 4 |
| Carruthers R MichaelChief Financial Officer | May 1, 2025 | May 7, 2025 | M · derivative | 5,209 | $0.00 | $0 | not reported | No | Form 4 |
| Derakhshan BehradChief Business Officer | May 1, 2025 | May 7, 2025 | M | 5,209 | $0.00 | $0 | 22,046 | No | Form 4 |
| Derakhshan BehradChief Business Officer | May 1, 2025 | May 7, 2025 | M · derivative | 5,209 | $0.00 | $0 | not reported | No | Form 4 |
| Donovan Joanne M.CMO | May 1, 2025 | May 7, 2025 | M | 10,417 | $0.00 | $0 | 26,775 | No | Form 4 |
| Donovan Joanne M.CMO | May 1, 2025 | May 7, 2025 | M · derivative | 10,417 | $0.00 | $0 | not reported | No | Form 4 |
| Koch KevinPresident and CEO | May 1, 2025 | May 7, 2025 | M | 10,417 | $0.00 | $0 | 24,895 | No | Form 4 |
| Koch KevinPresident and CEO | May 1, 2025 | May 7, 2025 | M · derivative | 10,417 | $0.00 | $0 | not reported | No | Form 4 |
| Moore John RGeneral Counsel | May 1, 2025 | May 7, 2025 | M | 5,209 | $0.00 | $0 | 8,461 | No | Form 4 |
| Moore John RGeneral Counsel | May 1, 2025 | May 7, 2025 | M · derivative | 5,209 | $0.00 | $0 | not reported | No | Form 4 |
| Russell Alan JChief Scientific Officer | May 1, 2025 | May 7, 2025 | M | 5,209 | $0.00 | $0 | 20,072 | No | Form 4 |
| Russell Alan JChief Scientific Officer | May 1, 2025 | May 7, 2025 | M · derivative | 5,209 | $0.00 | $0 | not reported | No | Form 4 |
| OrbiMed Genesis GP LLC | Apr 3, 2025 | Apr 4, 2025 | P | 372,578 | $20.13 | Purchase +$7,499,995 | 14,809,075 | No | Form 4 |
| OrbiMed Genesis GP LLC | Apr 3, 2025 | Apr 4, 2025 | P | 124,193 | $20.13 | Purchase +$2,500,005 | 443,792 | No | Form 4 |
| Thompson Peter A. | Apr 3, 2025 | Apr 4, 2025 | P | 372,578 | $20.13 | Purchase +$7,499,995 | 14,809,075 | No | Form 4 |
| Thompson Peter A. | Apr 3, 2025 | Apr 4, 2025 | P | 124,193 | $20.13 | Purchase +$2,500,005 | 443,792 | No | Form 4 |
| Fox Jonathan C | Apr 1, 2025 | Apr 3, 2025 | A | 559 | $0.00 | $0 | 11,416 | No | Form 4 |
| Koch KevinPresident and CEO | Mar 7, 2025 | Mar 11, 2025 | M | 100 | $0.18 | $18 | 14,578 | Yes | Form 4 |
| Koch KevinPresident and CEO | Mar 7, 2025 | Mar 11, 2025 | S | 100 | $30.00 | Sale −$3,000 | 14,478 | Yes | Form 4 |
| Koch KevinPresident and CEO | Mar 7, 2025 | Mar 11, 2025 | M · derivative | 100 | $0.18 | $18 | 41,545 | Yes | Form 4 |
| Russell Alan JChief Scientific Officer | Mar 7, 2025 | Mar 11, 2025 | M | 200 | $0.18 | $36 | 15,063 | Yes | Form 4 |
| Russell Alan JChief Scientific Officer | Mar 7, 2025 | Mar 11, 2025 | S | 200 | $30.02 | Sale −$6,004 | 14,863 | Yes | Form 4 |
| Russell Alan JChief Scientific Officer | Mar 7, 2025 | Mar 11, 2025 | M · derivative | 200 | $0.18 | $36 | 1,456,580 | Yes | Form 4 |
| Koch KevinPresident and CEO | Feb 6, 2025 | Feb 7, 2025 | M | 900 | $13.11 | $11,799 | 15,378 | Yes | Form 4 |
| Koch KevinPresident and CEO | Feb 6, 2025 | Feb 7, 2025 | S | 900 | $31.13 | Sale −$28,017 | 14,478 | Yes | Form 4 |
| Koch KevinPresident and CEO | Feb 6, 2025 | Feb 7, 2025 | M · derivative | 900 | $0.18 | $162 | 41,645 | Yes | Form 4 |
| Russell Alan JChief Scientific Officer | Feb 6, 2025 | Feb 7, 2025 | M | 1,200 | $0.18 | $216 | 16,063 | Yes | Form 4 |
| Russell Alan JChief Scientific Officer | Feb 6, 2025 | Feb 7, 2025 | S | 1,200 | $30.13 | Sale −$36,156 | 14,863 | Yes | Form 4 |
| Russell Alan JChief Scientific Officer | Feb 6, 2025 | Feb 7, 2025 | M · derivative | 1,200 | $0.18 | $216 | 1,347,565 | Yes | Form 4 |
| Derakhshan BehradChief Business Officer | Feb 5, 2025 | Feb 7, 2025 | M | 10,000 | $1.93 | $19,300 | 26,837 | No | Form 4 |
| Derakhshan BehradChief Business Officer | Feb 5, 2025 | Feb 7, 2025 | S | 10,000 | $30.03 | Sale −$300,300 | 16,837 | No | Form 4 |
| Derakhshan BehradChief Business Officer | Feb 5, 2025 | Feb 7, 2025 | M · derivative | 10,000 | $1.93 | $19,300 | 92,929 | No | Form 4 |
| Koch KevinPresident and CEO | Feb 5, 2025 | Feb 7, 2025 | M | 8,636 | $0.18 | $1,554 | 23,114 | Yes | Form 4 |
| Koch KevinPresident and CEO | Feb 5, 2025 | Feb 7, 2025 | S | 8,636 | $30.03 | Sale −$259,339 | 14,478 | Yes | Form 4 |
| Koch KevinPresident and CEO | Feb 5, 2025 | Feb 7, 2025 | M · derivative | 8,636 | $0.18 | $1,554 | 42,545 | Yes | Form 4 |
| Russell Alan JChief Scientific Officer | Feb 5, 2025 | Feb 7, 2025 | M | 8,015 | $0.18 | $1,443 | 22,878 | Yes | Form 4 |
| Russell Alan JChief Scientific Officer | Feb 5, 2025 | Feb 7, 2025 | S | 8,015 | $30.02 | Sale −$240,610 | 14,863 | Yes | Form 4 |
| Russell Alan JChief Scientific Officer | Feb 5, 2025 | Feb 7, 2025 | M · derivative | 8,015 | $0.18 | $1,443 | 1,348,765 | Yes | Form 4 |
| Donovan Joanne M.CMO | Jan 28, 2025 | Jan 30, 2025 | M | 25,000 | $7.08 | $177,000 | 41,358 | Yes | Form 4 |
| Donovan Joanne M.CMO | Jan 28, 2025 | Jan 30, 2025 | S | 25,000 | $27.63 | Sale −$690,750 | 16,358 | Yes | Form 4 |
| Donovan Joanne M.CMO | Jan 28, 2025 | Jan 30, 2025 | M · derivative | 25,000 | $7.08 | $177,000 | 175,000 | Yes | Form 4 |
| Blaustein RobertChief Development Officer | Jan 21, 2025 | Jan 23, 2025 | A · derivative | 30,000 | $0.00 | $0 | 30,000 | No | Form 4 |
| Blaustein RobertChief Development Officer | Jan 21, 2025 | Jan 23, 2025 | A · derivative | 160,000 | $27.39 | $4,382,400 | 160,000 | No | Form 4 |
| Russell Alan JChief Scientific Officer | Dec 30, 2024 | Dec 31, 2024 | M | 100,000 | $0.18 | $18,000 | 114,863 | Yes | Form 4 |
| Russell Alan JChief Scientific Officer | Dec 30, 2024 | Dec 31, 2024 | S | 100,000 | $27.37 | Sale −$2,737,000 | 14,863 | Yes | Form 4 |
| Russell Alan JChief Scientific Officer | Dec 30, 2024 | Dec 31, 2024 | M · derivative | 100,000 | $0.18 | $18,000 | 1,356,780 | Yes | Form 4 |
| Semigran MarcChief Development Officer | Dec 24, 2024 | Dec 27, 2024 | M | 29,709 | $8.94 | $265,598 | 36,425 | Yes | Form 4 |
| Semigran MarcChief Development Officer | Dec 24, 2024 | Dec 27, 2024 | S | 27,980 | $29.66 | Sale −$829,887 | 8,445 | Yes | Form 4 |
| Semigran MarcChief Development Officer | Dec 24, 2024 | Dec 27, 2024 | S | 1,729 | $30.08 | Sale −$52,008 | 6,716 | Yes | Form 4 |
| Semigran MarcChief Development Officer | Dec 24, 2024 | Dec 27, 2024 | M · derivative | 29,709 | $8.94 | $265,598 | 270,291 | Yes | Form 4 |
| Carruthers R MichaelChief Financial Officer | Oct 11, 2024 | Oct 16, 2024 | M | 70,000 | $0.71 | $49,700 | 76,904 | No | Form 4 |
| Carruthers R MichaelChief Financial Officer | Oct 11, 2024 | Oct 16, 2024 | M · derivative | 70,000 | $0.71 | $49,700 | 127,122 | No | Form 4 |
| Moore John RGeneral Counsel | Sep 23, 2024 | Sep 24, 2024 | M | 20,922 | $0.71 | $14,855 | 24,174 | No | Form 4 |
| Moore John RGeneral Counsel | Sep 23, 2024 | Sep 24, 2024 | S | 20,922 | $27.63 | Sale −$578,075 | 3,252 | No | Form 4 |
| Moore John RGeneral Counsel | Sep 23, 2024 | Sep 24, 2024 | M · derivative | 20,922 | $0.71 | $14,855 | 41,636 | No | Form 4 |
| Carruthers R MichaelChief Financial Officer | Sep 20, 2024 | Sep 24, 2024 | M | 46,068 | $1.93 | $88,911 | 81,996 | No | Form 4 |
| Carruthers R MichaelChief Financial Officer | Sep 20, 2024 | Sep 24, 2024 | S | 46,068 | $28.59 | Sale −$1,317,084 | 35,928 | No | Form 4 |
| Carruthers R MichaelChief Financial Officer | Sep 20, 2024 | Sep 24, 2024 | S | 4,064 | $28.59 | Sale −$116,190 | 31,864 | No | Form 4 |
| Carruthers R MichaelChief Financial Officer | Sep 20, 2024 | Sep 24, 2024 | S | 24,960 | $28.59 | Sale −$713,606 | 6,904 | No | Form 4 |
| Carruthers R MichaelChief Financial Officer | Sep 20, 2024 | Sep 24, 2024 | M | 50,000 | $1.93 | $96,500 | 56,904 | No | Form 4 |
| Carruthers R MichaelChief Financial Officer | Sep 20, 2024 | Sep 24, 2024 | S | 50,000 | $28.55 | Sale −$1,427,500 | 6,904 | No | Form 4 |
| Carruthers R MichaelChief Financial Officer | Sep 20, 2024 | Sep 24, 2024 | M · derivative | 96,068 | $1.93 | $185,411 | 40,990 | No | Form 4 |
| Derakhshan BehradChief Business Officer | Sep 20, 2024 | Sep 24, 2024 | M | 42,068 | $1.93 | $81,191 | 57,189 | No | Form 4 |
| Derakhshan BehradChief Business Officer | Sep 20, 2024 | Sep 24, 2024 | S | 42,068 | $29.03 | Sale −$1,221,234 | 15,121 | No | Form 4 |
| Derakhshan BehradChief Business Officer | Sep 20, 2024 | Sep 24, 2024 | M · derivative | 42,068 | $1.93 | $81,191 | 102,949 | No | Form 4 |
| Donovan Joanne M.CMO | Sep 20, 2024 | Sep 24, 2024 | S | 7,162 | $28.29 | Sale −$202,613 | 14,538 | No | Form 4 |
| Moore John RGeneral Counsel | Sep 20, 2024 | Sep 24, 2024 | M | 50,000 | $0.71 | $35,500 | 53,252 | No | Form 4 |
| Moore John RGeneral Counsel | Sep 20, 2024 | Sep 24, 2024 | S | 50,000 | $28.37 | Sale −$1,418,500 | 3,252 | No | Form 4 |
| Moore John RGeneral Counsel | Sep 20, 2024 | Sep 24, 2024 | M · derivative | 50,000 | $0.71 | $35,500 | 62,558 | No | Form 4 |
| Russell Alan JChief Scientific Officer | Sep 20, 2024 | Sep 24, 2024 | M | 75,000 | $0.18 | $13,500 | 87,719 | No | Form 4 |
| Russell Alan JChief Scientific Officer | Sep 20, 2024 | Sep 24, 2024 | S | 74,185 | $28.25 | Sale −$2,095,726 | 13,534 | No | Form 4 |
| Russell Alan JChief Scientific Officer | Sep 20, 2024 | Sep 24, 2024 | S | 815 | $29.51 | Sale −$24,051 | 12,719 | No | Form 4 |
| Russell Alan JChief Scientific Officer | Sep 20, 2024 | Sep 24, 2024 | M · derivative | 75,000 | $0.18 | $13,500 | 1,456,780 | No | Form 4 |
| Carruthers R MichaelChief Financial Officer | Aug 12, 2024 | Aug 14, 2024 | A · derivative | 138,750 | $17.05 | $2,365,688 | 138,750 | No | Form 4 |
| Carruthers R MichaelChief Financial Officer | Aug 12, 2024 | Aug 14, 2024 | A · derivative | 23,125 | $0.00 | $0 | 23,125 | No | Form 4 |
| Donovan Joanne M.CMO | Aug 12, 2024 | Aug 14, 2024 | A · derivative | 138,750 | $17.05 | $2,365,688 | 138,750 | No | Form 4 |
| Donovan Joanne M.CMO | Aug 12, 2024 | Aug 14, 2024 | A · derivative | 23,125 | $0.00 | $0 | 23,125 | No | Form 4 |
| Koch KevinPresident and CEO | Aug 12, 2024 | Aug 14, 2024 | A · derivative | 431,250 | $17.05 | $7,352,813 | 431,250 | No | Form 4 |
| Koch KevinPresident and CEO | Aug 12, 2024 | Aug 14, 2024 | A · derivative | 71,875 | $0.00 | $0 | 71,875 | No | Form 4 |
| Derakhshan BehradChief Business Officer | Aug 12, 2024 | Aug 14, 2024 | A · derivative | 138,750 | $17.05 | $2,365,688 | 138,750 | No | Form 4 |
| Derakhshan BehradChief Business Officer | Aug 12, 2024 | Aug 14, 2024 | A · derivative | 23,125 | $0.00 | $0 | 23,125 | No | Form 4 |
| Moore John RGeneral Counsel | Aug 12, 2024 | Aug 14, 2024 | A · derivative | 138,750 | $17.05 | $2,365,688 | 138,750 | No | Form 4 |
| Moore John RGeneral Counsel | Aug 12, 2024 | Aug 14, 2024 | A · derivative | 23,125 | $0.00 | $0 | 23,125 | No | Form 4 |
| Russell Alan JChief Scientific Officer | Aug 12, 2024 | Aug 14, 2024 | A · derivative | 138,750 | $17.05 | $2,365,688 | 138,750 | No | Form 4 |
| Russell Alan JChief Scientific Officer | Aug 12, 2024 | Aug 14, 2024 | A · derivative | 23,125 | $0.00 | $0 | 23,125 | No | Form 4 |
| Semigran MarcChief Development Officer | Aug 12, 2024 | Aug 14, 2024 | A · derivative | 138,750 | $17.05 | $2,365,688 | 138,750 | No | Form 4 |
| Semigran MarcChief Development Officer | Aug 12, 2024 | Aug 14, 2024 | A · derivative | 23,125 | $0.00 | $0 | 23,125 | No | Form 4 |
| Root Jonathan D | Jun 10, 2024 | Jun 12, 2024 | A · derivative | 20,594 | $17.13 | $352,775 | 20,594 | No | Form 4 |
| Edris Badreddin | Jun 10, 2024 | Jun 12, 2024 | A · derivative | 20,594 | $17.13 | $352,775 | 20,594 | No | Form 4 |
| Brege Laura | Jun 10, 2024 | Jun 12, 2024 | A · derivative | 20,594 | $17.13 | $352,775 | 20,594 | No | Form 4 |
| Morris Arlene | Jun 10, 2024 | Jun 12, 2024 | A · derivative | 20,594 | $17.13 | $352,775 | 20,594 | No | Form 4 |
| Fox Jonathan C | Jun 10, 2024 | Jun 12, 2024 | A · derivative | 20,594 | $17.13 | $352,775 | 20,594 | No | Form 4 |
| Thompson Peter A. | Jun 10, 2024 | Jun 12, 2024 | A · derivative | 20,594 | $17.13 | $352,775 | 20,594 | No | Form 4 |
| Morris Arlene | May 6, 2024 | May 7, 2024 | A · derivative | 34,311 | $20.34 | $697,886 | 34,311 | No | Form 4 |
| Koch KevinPresident and CEO | May 2, 2024 | May 3, 2024 | S | 3,152 | $18.91 | Sale −$59,604 | 14,478 | No | Form 4 |
| Donovan Joanne M.CMO | May 2, 2024 | May 3, 2024 | S | 3,682 | $18.91 | Sale −$69,627 | 19,897 | No | Form 4 |
| Russell Alan JChief Scientific Officer | May 2, 2024 | May 3, 2024 | S | 1,576 | $18.91 | Sale −$29,802 | 7,238 | No | Form 4 |
| Derakhshan BehradChief Business Officer | May 2, 2024 | May 3, 2024 | S | 1,718 | $18.91 | Sale −$32,487 | 13,422 | No | Form 4 |
| Carruthers R MichaelChief Financial Officer | May 2, 2024 | May 3, 2024 | S | 2,157 | $18.91 | Sale −$40,789 | 35,230 | No | Form 4 |
| Moore John RGeneral Counsel | May 2, 2024 | May 3, 2024 | S | 1,956 | $18.91 | Sale −$36,988 | 3,252 | No | Form 4 |
| Koch KevinPresident and CEO | May 1, 2024 | May 3, 2024 | M | 10,417 | $0.00 | $0 | 17,630 | No | Form 4 |
| Koch KevinPresident and CEO | May 1, 2024 | May 3, 2024 | M · derivative | 10,417 | $0.00 | $0 | 10,417 | No | Form 4 |
| Donovan Joanne M.CMO | May 1, 2024 | May 3, 2024 | M | 10,417 | $0.00 | $0 | 23,579 | No | Form 4 |
| Donovan Joanne M.CMO | May 1, 2024 | May 3, 2024 | M · derivative | 10,417 | $0.00 | $0 | 10,417 | No | Form 4 |
| Russell Alan JChief Scientific Officer | May 1, 2024 | May 3, 2024 | M | 5,208 | $0.00 | $0 | 8,814 | No | Form 4 |
| Russell Alan JChief Scientific Officer | May 1, 2024 | May 3, 2024 | M · derivative | 5,208 | $0.00 | $0 | 5,209 | No | Form 4 |
| Derakhshan BehradChief Business Officer | May 1, 2024 | May 3, 2024 | M | 5,208 | $0.00 | $0 | 15,140 | No | Form 4 |
| Derakhshan BehradChief Business Officer | May 1, 2024 | May 3, 2024 | M · derivative | 5,208 | $0.00 | $0 | 5,209 | No | Form 4 |
| Carruthers R MichaelChief Financial Officer | May 1, 2024 | May 3, 2024 | M | 5,208 | $0.00 | $0 | 37,387 | No | Form 4 |
| Carruthers R MichaelChief Financial Officer | May 1, 2024 | May 3, 2024 | M · derivative | 5,208 | $0.00 | $0 | 5,209 | No | Form 4 |
| Moore John RGeneral Counsel | May 1, 2024 | May 3, 2024 | M | 5,208 | $0.00 | $0 | 5,208 | No | Form 4 |
| Moore John RGeneral Counsel | May 1, 2024 | May 3, 2024 | M · derivative | 5,208 | $0.00 | $0 | 5,209 | No | Form 4 |
| Derakhshan BehradChief Business Officer | Feb 9, 2024 | Feb 9, 2024 | M | 4,800 | $1.93 | $9,264 | 11,820 | Yes | Form 4 |
| Derakhshan BehradChief Business Officer | Feb 9, 2024 | Feb 9, 2024 | S | 4,800 | $20.04 | Sale −$96,192 | 7,020 | Yes | Form 4 |
| Derakhshan BehradChief Business Officer | Feb 9, 2024 | Feb 9, 2024 | M · derivative | 4,800 | $1.93 | $9,264 | 145,017 | Yes | Form 4 |
| Moore John RGeneral Counsel | Feb 9, 2024 | Feb 9, 2024 | M | 8,029 | $1.93 | $15,496 | 8,029 | Yes | Form 4 |
| Moore John RGeneral Counsel | Feb 9, 2024 | Feb 9, 2024 | S | 8,029 | $20.01 | Sale −$160,660 | not reported | Yes | Form 4 |
| Moore John RGeneral Counsel | Feb 9, 2024 | Feb 9, 2024 | M · derivative | 8,029 | $1.93 | $15,496 | 93,162 | Yes | Form 4 |
| Derakhshan BehradChief Business Officer | Feb 8, 2024 | Feb 9, 2024 | M | 4,600 | $1.93 | $8,878 | 11,620 | Yes | Form 4 |
| Derakhshan BehradChief Business Officer | Feb 8, 2024 | Feb 9, 2024 | S | 4,600 | $20.01 | Sale −$92,046 | 7,020 | Yes | Form 4 |
| Derakhshan BehradChief Business Officer | Feb 8, 2024 | Feb 9, 2024 | M · derivative | 4,600 | $1.93 | $8,878 | 149,817 | Yes | Form 4 |
| Moore John RGeneral Counsel | Feb 8, 2024 | Feb 9, 2024 | M | 3,813 | $1.93 | $7,359 | 3,813 | Yes | Form 4 |
| Moore John RGeneral Counsel | Feb 8, 2024 | Feb 9, 2024 | S | 3,813 | $20.01 | Sale −$76,298 | not reported | Yes | Form 4 |
| Moore John RGeneral Counsel | Feb 8, 2024 | Feb 9, 2024 | M · derivative | 3,813 | $1.93 | $7,359 | 101,191 | Yes | Form 4 |
| Derakhshan BehradChief Business Officer | Feb 7, 2024 | Feb 9, 2024 | M | 600 | $1.93 | $1,158 | 7,620 | Yes | Form 4 |
| Derakhshan BehradChief Business Officer | Feb 7, 2024 | Feb 9, 2024 | S | 600 | $20.00 | Sale −$12,000 | 7,020 | Yes | Form 4 |
| Derakhshan BehradChief Business Officer | Feb 7, 2024 | Feb 9, 2024 | M · derivative | 600 | $1.93 | $1,158 | 154,417 | Yes | Form 4 |
| Moore John RGeneral Counsel | Feb 7, 2024 | Feb 9, 2024 | M | 17,993 | $1.93 | $34,726 | 17,993 | Yes | Form 4 |
| Moore John RGeneral Counsel | Feb 7, 2024 | Feb 9, 2024 | S | 17,993 | $20.00 | Sale −$359,860 | not reported | Yes | Form 4 |
| Moore John RGeneral Counsel | Feb 7, 2024 | Feb 9, 2024 | M · derivative | 17,993 | $1.93 | $34,726 | 105,004 | Yes | Form 4 |
| OrbiMed Capital GP VI LLC | Jan 23, 2024 | Jan 25, 2024 | P | 454,545 | $11.00 | Purchase +$4,999,995 | 14,436,497 | No | Form 4 |
| Thompson Peter A. | Jan 23, 2024 | Jan 25, 2024 | P | 454,545 | $11.00 | Purchase +$4,999,995 | 14,436,497 | No | Form 4 |
| Carruthers R MichaelChief Financial Officer | Jan 23, 2024 | Jan 25, 2024 | M | 90,000 | $1.93 | $173,700 | 119,024 | Yes | Form 4 |
| Carruthers R MichaelChief Financial Officer | Jan 23, 2024 | Jan 25, 2024 | S | 90,000 | $15.78 | Sale −$1,420,200 | 29,024 | Yes | Form 4 |
| Carruthers R MichaelChief Financial Officer | Jan 23, 2024 | Jan 25, 2024 | M · derivative | 90,000 | $1.93 | $173,700 | 137,058 | Yes | Form 4 |
| Moore John RGeneral Counsel | Dec 27, 2023 | Dec 28, 2023 | S | 8,497 | $10.50 | Sale −$89,219 | not reported | No | Form 4 |
| Russell Alan JChief Scientific Officer | Dec 26, 2023 | Dec 28, 2023 | S | 172,585 | $9.33 | Sale −$1,610,218 | 3,606 | No | Form 4 |
| Fox Jonathan C | Dec 26, 2023 | Dec 28, 2023 | P | 10,857 | $9.30 | Purchase +$100,970 | 10,857 | No | Form 4 |