EYPTEyePoint, Inc.
- Market cap
- $34.87M
- as of 2026-10-23
- Latest close
- $0.40
- as of 2026-10-23
- Sector
- Healthcare
- as of 2026-10-24
- Industry
- Biotechnology
- as of 2026-10-24
Cluster
No cluster in the last 90 days under the default rule (14d · ≥2 insiders · all roles).
Form 4 historysince 2023-10-17
Dashed line = amended filing (Form 4/A)
| Insider | Traded | Filed | Type | Shares | Price | Value | Owned after | 10b5-1 plan | Filing |
|---|---|---|---|---|---|---|---|---|---|
| Elston GeorgeChief Financial Officer | Aug 20 | Aug 24 | J | 5,000 | $0.00 | $0 | 25,000 | No | Form 4 |
| Elston GeorgeChief Financial Officer | Aug 20 | Aug 24 | J | 5,000 | $0.00 | $0 | 96,691 | No | Form 4 |
| Elston GeorgeChief Financial Officer | Aug 20 | Aug 24 | G | 64,953 | $0.00 | $0 | 32,517 | No | Form 4 |
| Elston GeorgeChief Financial Officer | Aug 20 | Aug 24 | G | 64,953 | $0.00 | $0 | 64,953 | No | Form 4 |
| Zaderej Karen L. | Aug 18 | Aug 18 | P | 10,600 | $4.93 | Purchase +$52,258 | 49,100 | No | Form 4 |
| Duker Jay S.President and CEO | Jul 10 | Jul 14 | M | 16,667 | $0.00 | $0 | 17,653 | No | Form 4 |
| Duker Jay S.President and CEO | Jul 10 | Jul 14 | F | 8,059 | $14.72 | $118,628 | 9,594 | No | Form 4 |
| Duker Jay S.President and CEO | Jul 10 | Jul 14 | M · derivative | 16,667 | $0.00 | $0 | not reported | No | Form 4 |
| Ribeiro RamiroChief Medical Officer | Jun 30 | Jul 2 | M | 2,437 | $8.26 | $20,130 | 2,437 | Yes | Form 4 |
| Ribeiro RamiroChief Medical Officer | Jun 30 | Jul 2 | M | 2,438 | $8.26 | $20,138 | 4,875 | Yes | Form 4 |
| Ribeiro RamiroChief Medical Officer | Jun 30 | Jul 2 | S | 2,437 | $15.00 | Sale −$36,555 | 2,438 | Yes | Form 4 |
| Ribeiro RamiroChief Medical Officer | Jun 30 | Jul 2 | S | 2,438 | $15.02 | Sale −$36,619 | not reported | Yes | Form 4 |
| Ribeiro RamiroChief Medical Officer | Jun 30 | Jul 2 | M · derivative | 2,437 | $8.26 | $20,130 | 78,001 | Yes | Form 4 |
| Ribeiro RamiroChief Medical Officer | Jun 30 | Jul 2 | M · derivative | 2,438 | $8.26 | $20,138 | 75,563 | Yes | Form 4 |
| Elston GeorgeChief Financial Officer | May 25 | May 27 | M | 7,500 | $0.00 | $0 | 95,318 | No | Form 4 |
| Elston GeorgeChief Financial Officer | May 25 | May 27 | F | 3,627 | $12.93 | $46,897 | 91,691 | No | Form 4 |
| Elston GeorgeChief Financial Officer | May 25 | May 27 | M · derivative | 7,500 | $0.00 | $0 | not reported | No | Form 4 |
| Ribeiro RamiroChief Medical Officer | Apr 17 | Apr 20 | M | 2,437 | $8.26 | $20,130 | 2,437 | Yes | Form 4 |
| Ribeiro RamiroChief Medical Officer | Apr 17 | Apr 20 | S | 2,437 | $15.00 | Sale −$36,555 | not reported | Yes | Form 4 |
| Ribeiro RamiroChief Medical Officer | Apr 17 | Apr 20 | M · derivative | 2,437 | $8.26 | $20,130 | 80,438 | Yes | Form 4 |
| Duker Jay S.President and CEO | Mar 23 | Mar 24 | J | 76,766 | $13.11 | $1,006,402 | 986 | No | Form 4 |
| Duker Jay S.President and CEO | Mar 23 | Mar 24 | J | 76,766 | $13.11 | $1,006,402 | 177,431 | No | Form 4 |
| Duker Jay S.President and CEO | Mar 23 | Mar 24 | J · derivative | 52,500 | $8.75 | $459,375 | 7,800 | No | Form 4 |
| Duker Jay S.President and CEO | Mar 23 | Mar 24 | J · derivative | 52,500 | $8.75 | $459,375 | 52,500 | No | Form 4 |
| Duker Jay S.President and CEO | Mar 23 | Mar 24 | J · derivative | 97,500 | $9.57 | $933,075 | 82,500 | No | Form 4 |
| Duker Jay S.President and CEO | Mar 23 | Mar 24 | J · derivative | 97,500 | $9.57 | $933,075 | 97,500 | No | Form 4 |
| Duker Jay S.President and CEO | Mar 16 | Mar 16 | P | 1,500 | $13.15 | Purchase +$19,725 | 100,665 | No | Form 4 |
| Elston GeorgeChief Financial Officer | Mar 2 | Mar 6 | G | 5,000 | $0.00 | $0 | 87,818 | No | Form 4 |
| Elston GeorgeChief Financial Officer | Mar 2 | Mar 6 | G | 5,000 | $0.00 | $0 | 30,000 | No | Form 4 |
| Ribeiro RamiroChief Medical Officer | Mar 4 | Mar 5 | M | 2,438 | $8.26 | $20,138 | 2,438 | Yes | Form 4 |
| Ribeiro RamiroChief Medical Officer | Mar 4 | Mar 5 | S | 2,438 | $17.87 | Sale −$43,567 | not reported | Yes | Form 4 |
| Ribeiro RamiroChief Medical Officer | Mar 4 | Mar 5 | M · derivative | 2,438 | $8.26 | $20,138 | 82,875 | Yes | Form 4 |
| Ribeiro RamiroChief Medical Officer | Feb 17 | Feb 18 | M | 2,437 | $8.26 | $20,130 | 2,437 | Yes | Form 4 |
| Ribeiro RamiroChief Medical Officer | Feb 17 | Feb 18 | S | 2,437 | $15.00 | Sale −$36,555 | not reported | Yes | Form 4 |
| Ribeiro RamiroChief Medical Officer | Feb 17 | Feb 18 | M · derivative | 2,437 | $8.26 | $20,130 | 85,313 | Yes | Form 4 |
| Elston GeorgeChief Financial Officer | Jan 6 | Jan 7 | M | 15,285 | $0.00 | $0 | 96,339 | No | Form 4 |
| Elston GeorgeChief Financial Officer | Jan 6 | Jan 7 | F | 4,487 | $16.86 | $75,651 | 91,852 | No | Form 4 |
| Elston GeorgeChief Financial Officer | Jan 6 | Jan 7 | M · derivative | 15,285 | $0.00 | $0 | not reported | No | Form 4 |
| Lurker Nancy | Jan 6 | Jan 7 | M | 75,133 | $0.00 | $0 | 294,346 | No | Form 4 |
| Lurker Nancy | Jan 6 | Jan 7 | M · derivative | 75,133 | $0.00 | $0 | not reported | No | Form 4 |
| Duker Jay S.President and CEO | Jan 6 | Jan 7 | M | 20,793 | $0.00 | $0 | 87,806 | No | Form 4 |
| Duker Jay S.President and CEO | Jan 6 | Jan 7 | F | 10,054 | $16.86 | $169,510 | 77,752 | No | Form 4 |
| Duker Jay S.President and CEO | Jan 6 | Jan 7 | M · derivative | 20,793 | $0.00 | $0 | not reported | No | Form 4 |
| Ribeiro RamiroChief Medical Officer | Jan 5 | Jan 7 | M | 29,250 | $8.26 | $241,605 | 42,544 | Yes | Form 4 |
| Ribeiro RamiroChief Medical Officer | Jan 5 | Jan 7 | S | 42,544 | $17.10 | Sale −$727,502 | not reported | Yes | Form 4 |
| Ribeiro RamiroChief Medical Officer | Jan 5 | Jan 7 | M · derivative | 29,250 | $8.26 | $241,605 | 87,750 | Yes | Form 4 |
| Elston GeorgeChief Financial Officer | Jan 5 | Jan 6 | M | 15,000 | $0.00 | $0 | 85,457 | No | Form 4 |
| Elston GeorgeChief Financial Officer | Jan 5 | Jan 6 | F | 4,403 | $17.43 | $76,744 | 81,054 | No | Form 4 |
| Elston GeorgeChief Financial Officer | Jan 5 | Jan 6 | M · derivative | 15,000 | $0.00 | $0 | 15,000 | No | Form 4 |
| Lurker Nancy | Jan 5 | Jan 6 | M | 12,666 | $0.00 | $0 | 219,213 | No | Form 4 |
| Lurker Nancy | Jan 5 | Jan 6 | M · derivative | 12,666 | $0.00 | $0 | 12,667 | No | Form 4 |
| Duker Jay S.President and CEO | Jan 5 | Jan 6 | M | 30,000 | $0.00 | $0 | 81,518 | No | Form 4 |
| Duker Jay S.President and CEO | Jan 5 | Jan 6 | F | 14,505 | $17.43 | $252,822 | 67,013 | No | Form 4 |
| Duker Jay S.President and CEO | Jan 5 | Jan 6 | M · derivative | 30,000 | $0.00 | $0 | 30,000 | No | Form 4 |
| Elston GeorgeChief Financial Officer | Jan 3 | Jan 6 | M | 19,667 | $0.00 | $0 | 76,781 | No | Form 4 |
| Elston GeorgeChief Financial Officer | Jan 3 | Jan 6 | F | 6,324 | $17.48 | $110,544 | 70,457 | No | Form 4 |
| Elston GeorgeChief Financial Officer | Jan 3 | Jan 6 | M · derivative | 19,667 | $0.00 | $0 | 39,333 | No | Form 4 |
| Duker Jay S.President and CEO | Jan 3 | Jan 6 | M | 65,000 | $0.00 | $0 | 74,965 | No | Form 4 |
| Duker Jay S.President and CEO | Jan 3 | Jan 6 | F | 23,447 | $17.48 | $409,854 | 51,518 | No | Form 4 |
| Duker Jay S.President and CEO | Jan 3 | Jan 6 | M · derivative | 65,000 | $0.00 | $0 | 130,000 | No | Form 4 |
| Ribeiro RamiroChief Medical Officer | Jan 3 | Jan 6 | M | 19,667 | $0.00 | $0 | 19,667 | No | Form 4 |
| Ribeiro RamiroChief Medical Officer | Jan 3 | Jan 6 | F | 6,373 | $17.48 | $111,400 | 13,294 | No | Form 4 |
| Ribeiro RamiroChief Medical Officer | Jan 3 | Jan 6 | M · derivative | 19,667 | $0.00 | $0 | 39,333 | No | Form 4 |
| Hassan Fred | Jan 2 | Jan 6 | A · derivative | 40,000 | $17.48 | $699,200 | 40,000 | No | Form 4 |
| Ando Goran | Jan 2 | Jan 6 | A · derivative | 41,500 | $17.48 | $725,420 | 41,500 | No | Form 4 |
| Dicicco Wendy F | Jan 2 | Jan 6 | A · derivative | 40,000 | $17.48 | $699,200 | 40,000 | No | Form 4 |
| Elston GeorgeChief Financial Officer | Jan 2 | Jan 6 | A · derivative | 63,000 | $0.00 | $0 | 63,000 | No | Form 4 |
| Elston GeorgeChief Financial Officer | Jan 2 | Jan 6 | A · derivative | 126,000 | $17.48 | $2,202,480 | 126,000 | No | Form 4 |
| Lurker Nancy | Jan 2 | Jan 6 | A · derivative | 40,000 | $17.48 | $699,200 | 40,000 | No | Form 4 |
| Landis John B. | Jan 2 | Jan 6 | A · derivative | 40,000 | $17.48 | $699,200 | 40,000 | No | Form 4 |
| Zaderej Karen L. | Jan 2 | Jan 6 | A · derivative | 40,000 | $17.48 | $699,200 | 40,000 | No | Form 4 |
| Duker Jay S.President and CEO | Jan 2 | Jan 6 | A · derivative | 165,000 | $0.00 | $0 | 165,000 | No | Form 4 |
| Duker Jay S.President and CEO | Jan 2 | Jan 6 | A · derivative | 331,000 | $17.48 | $5,785,880 | 331,000 | No | Form 4 |
| Duty Stuart | Jan 2 | Jan 6 | A · derivative | 40,000 | $17.48 | $699,200 | 40,000 | No | Form 4 |
| Ribeiro RamiroChief Medical Officer | Jan 2 | Jan 6 | A · derivative | 85,700 | $0.00 | $0 | 85,700 | No | Form 4 |
| Ribeiro RamiroChief Medical Officer | Jan 2 | Jan 6 | A · derivative | 171,400 | $17.48 | $2,996,072 | 171,400 | No | Form 4 |
| Sanders Reginald J. | Jan 2 | Jan 6 | A · derivative | 40,000 | $17.48 | $699,200 | 40,000 | No | Form 4 |
| Elston GeorgeChief Financial Officer | Dec 19, 2025 | Dec 23, 2025 | G | 5,000 | $0.00 | $0 | 57,114 | No | Form 4 |
| Elston GeorgeChief Financial Officer | Dec 19, 2025 | Dec 23, 2025 | G | 5,000 | $0.00 | $0 | 25,000 | No | Form 4 |
| Cormorant Asset Management, LP | Dec 4, 2025 | Dec 8, 2025 | S | 60,000 | $15.70 | Sale −$942,000 | 8,265,000 | No | Form 4 |
| Lurker Nancy | Dec 4, 2025 | Dec 5, 2025 | S | 9,300 | $15.11 | Sale −$140,523 | 206,547 | Yes | Form 4 |
| Lurker Nancy | Nov 28, 2025 | Dec 1, 2025 | S | 500 | $14.95 | Sale −$7,475 | 215,847 | Yes | Form 4 |
| Lurker Nancy | Nov 26, 2025 | Dec 1, 2025 | S | 200 | $14.95 | Sale −$2,990 | 216,347 | Yes | Form 4 |
| Ribeiro RamiroChief Medical Officer | Nov 11, 2025 | Nov 12, 2025 | S | 2,722 | $11.61 | Sale −$31,602 | not reported | Yes | Form 4 |
| Elston GeorgeChief Financial Officer | Sep 19, 2025 | Sep 22, 2025 | G | 20,000 | $0.00 | $0 | 62,114 | No | Form 4 |
| Elston GeorgeChief Financial Officer | Sep 19, 2025 | Sep 22, 2025 | G | 20,000 | $0.00 | $0 | 20,000 | No | Form 4 |
| Zaderej Karen L. | Jul 11, 2025 | Jul 11, 2025 | M | 2,000 | $0.00 | $0 | 38,500 | No | Form 4 |
| Zaderej Karen L. | Jul 11, 2025 | Jul 11, 2025 | M · derivative | 2,000 | $0.00 | $0 | not reported | No | Form 4 |
| Duker Jay S.President and CEO | Jul 10, 2025 | Jul 11, 2025 | M | 16,667 | $0.00 | $0 | 17,653 | No | Form 4 |
| Duker Jay S.President and CEO | Jul 10, 2025 | Jul 11, 2025 | F | 7,688 | $11.06 | $85,029 | 9,965 | No | Form 4 |
| Duker Jay S.President and CEO | Jul 10, 2025 | Jul 11, 2025 | M · derivative | 16,667 | $0.00 | $0 | 16,667 | No | Form 4 |
| Lurker Nancy | Jul 10, 2025 | Jul 11, 2025 | M | 11,111 | $0.00 | $0 | 216,547 | No | Form 4 |
| Lurker Nancy | Jul 10, 2025 | Jul 11, 2025 | M · derivative | 11,111 | $0.00 | $0 | 11,112 | No | Form 4 |
| Lurker Nancy | Jul 2, 2025 | Jul 2, 2025 | G · derivative | 31,165 | $13.13 | $409,196 | not reported | No | Form 4 |
| Lurker Nancy | Jul 2, 2025 | Jul 2, 2025 | G · derivative | 31,165 | $13.13 | $409,196 | 213,700 | No | Form 4 |
| Lurker Nancy | Jul 2, 2025 | Jul 2, 2025 | G · derivative | 55,000 | $10.13 | $557,150 | 40,000 | No | Form 4 |
| Lurker Nancy | Jul 2, 2025 | Jul 2, 2025 | G · derivative | 55,000 | $10.13 | $557,150 | 200,000 | No | Form 4 |
| Lurker Nancy | Jul 2, 2025 | Jul 2, 2025 | G · derivative | 103,308 | $3.26 | $336,784 | 178,442 | No | Form 4 |
| Lurker Nancy | Jul 2, 2025 | Jul 2, 2025 | G · derivative | 103,308 | $3.26 | $336,784 | 272,358 | No | Form 4 |
| Lurker Nancy | Jul 2, 2025 | Jul 2, 2025 | G · derivative | 15,278 | $9.11 | $139,183 | 34,722 | No | Form 4 |
| Lurker Nancy | Jul 2, 2025 | Jul 2, 2025 | G · derivative | 15,278 | $9.11 | $139,183 | 31,944 | No | Form 4 |
| Lurker Nancy | Jul 2, 2025 | Jul 2, 2025 | G · derivative | 27,270 | $20.40 | $556,308 | 49,730 | No | Form 4 |
| Lurker Nancy | Jul 2, 2025 | Jul 2, 2025 | G · derivative | 27,270 | $20.40 | $556,308 | 27,270 | No | Form 4 |
| Duker Jay S.President and CEO | Jun 23, 2025 | Jun 25, 2025 | J | 56,665 | $8.21 | $465,220 | 986 | No | Form 4 |
| Elston GeorgeChief Financial Officer | May 25, 2025 | May 27, 2025 | M | 7,500 | $0.00 | $0 | 83,050 | No | Form 4 |
| Elston GeorgeChief Financial Officer | May 25, 2025 | May 27, 2025 | F | 2,202 | $5.68 | $12,507 | 80,848 | No | Form 4 |
| Elston GeorgeChief Financial Officer | May 25, 2025 | May 27, 2025 | M · derivative | 7,500 | $0.00 | $0 | 7,500 | No | Form 4 |
| Zaderej Karen L. | May 19, 2025 | May 19, 2025 | P | 5,000 | $5.99 | Purchase +$29,950 | 36,500 | No | Form 4 |
| Zaderej Karen L. | May 16, 2025 | May 19, 2025 | P | 5,000 | $5.81 | Purchase +$29,050 | 31,500 | No | Form 4 |
| Zaderej Karen L. | May 15, 2025 | May 15, 2025 | P | 5,000 | $5.47 | Purchase +$27,350 | 26,500 | No | Form 4 |
| Zaderej Karen L. | May 14, 2025 | May 15, 2025 | P | 5,000 | $5.42 | Purchase +$27,100 | 21,500 | No | Form 4 |
| Duker Jay S.President and CEO | Mar 19, 2025 | Mar 20, 2025 | J | 20,000 | $6.16 | $123,200 | 57,651 | No | Form 4 |
| Duker Jay S.President and CEO | Feb 9, 2025 | Feb 11, 2025 | M | 7,000 | $0.00 | $0 | 79,706 | No | Form 4 |
| Duker Jay S.President and CEO | Feb 9, 2025 | Feb 11, 2025 | F | 2,055 | $6.50 | $13,358 | 77,651 | No | Form 4 |
| Duker Jay S.President and CEO | Feb 9, 2025 | Feb 11, 2025 | M · derivative | 7,000 | $0.00 | $0 | not reported | No | Form 4 |
| Lurker Nancy | Feb 9, 2025 | Feb 11, 2025 | M | 20,000 | $0.00 | $0 | 205,436 | No | Form 4 |
| Lurker Nancy | Feb 9, 2025 | Feb 11, 2025 | M · derivative | 20,000 | $0.00 | $0 | not reported | No | Form 4 |
| Elston GeorgeChief Financial Officer | Feb 9, 2025 | Feb 11, 2025 | M | 5,834 | $0.00 | $0 | 75,550 | No | Form 4 |
| Elston GeorgeChief Financial Officer | Feb 9, 2025 | Feb 11, 2025 | M · derivative | 5,834 | $0.00 | $0 | not reported | No | Form 4 |
| Sanders Reginald J. | Jan 8, 2025 | Jan 8, 2025 | A · derivative | 80,000 | $9.11 | $728,800 | 80,000 | No | Form 4 |
| Duker Jay S.President and CEO | Jan 6, 2025 | Jan 7, 2025 | M | 20,794 | $0.00 | $0 | 78,814 | No | Form 4 |
| Duker Jay S.President and CEO | Jan 6, 2025 | Jan 7, 2025 | F | 6,108 | $8.68 | $53,017 | 72,706 | No | Form 4 |
| Duker Jay S.President and CEO | Jan 6, 2025 | Jan 7, 2025 | M · derivative | 20,794 | $0.00 | $0 | 39,206 | No | Form 4 |
| Lurker Nancy | Jan 6, 2025 | Jan 7, 2025 | M | 75,134 | $0.00 | $0 | 185,436 | No | Form 4 |
| Lurker Nancy | Jan 6, 2025 | Jan 7, 2025 | M · derivative | 75,134 | $0.00 | $0 | 75,133 | No | Form 4 |
| Elston GeorgeChief Financial Officer | Jan 6, 2025 | Jan 7, 2025 | M | 15,285 | $0.00 | $0 | 73,374 | No | Form 4 |
| Elston GeorgeChief Financial Officer | Jan 6, 2025 | Jan 7, 2025 | F | 4,808 | $8.68 | $41,733 | 68,566 | No | Form 4 |
| Elston GeorgeChief Financial Officer | Jan 6, 2025 | Jan 7, 2025 | M · derivative | 15,285 | $0.00 | $0 | 14,715 | No | Form 4 |
| Duker Jay S.President and CEO | Jan 5, 2025 | Jan 7, 2025 | M | 30,000 | $0.00 | $0 | 68,027 | No | Form 4 |
| Duker Jay S.President and CEO | Jan 5, 2025 | Jan 7, 2025 | F | 10,007 | $8.26 | $82,658 | 58,020 | No | Form 4 |
| Duker Jay S.President and CEO | Jan 5, 2025 | Jan 7, 2025 | M · derivative | 30,000 | $0.00 | $0 | 60,000 | No | Form 4 |
| Landis John B. | Jan 5, 2025 | Jan 7, 2025 | M | 10,000 | $0.00 | $0 | 21,400 | No | Form 4 |
| Landis John B. | Jan 5, 2025 | Jan 7, 2025 | M · derivative | 10,000 | $0.00 | $0 | not reported | No | Form 4 |
| Lurker Nancy | Jan 5, 2025 | Jan 7, 2025 | M | 12,667 | $0.00 | $0 | 110,302 | No | Form 4 |
| Lurker Nancy | Jan 5, 2025 | Jan 7, 2025 | M · derivative | 12,667 | $0.00 | $0 | 25,333 | No | Form 4 |
| Elston GeorgeChief Financial Officer | Jan 5, 2025 | Jan 7, 2025 | M | 15,000 | $0.00 | $0 | 63,356 | No | Form 4 |
| Elston GeorgeChief Financial Officer | Jan 5, 2025 | Jan 7, 2025 | F | 5,267 | $8.26 | $43,505 | 58,089 | No | Form 4 |
| Elston GeorgeChief Financial Officer | Jan 5, 2025 | Jan 7, 2025 | M · derivative | 15,000 | $0.00 | $0 | 30,000 | No | Form 4 |
| Duker Jay S.President and CEO | Jan 3, 2025 | Jan 7, 2025 | A · derivative | 195,000 | $0.00 | $0 | 228,334 | No | Form 4 |
| Duker Jay S.President and CEO | Jan 3, 2025 | Jan 7, 2025 | A · derivative | 390,000 | $8.26 | $3,221,400 | 390,000 | No | Form 4 |
| Landis John B. | Jan 3, 2025 | Jan 7, 2025 | A · derivative | 40,000 | $8.26 | $330,400 | 40,000 | No | Form 4 |
| Lurker Nancy | Jan 3, 2025 | Jan 7, 2025 | A · derivative | 40,000 | $8.26 | $330,400 | 40,000 | No | Form 4 |
| Elston GeorgeChief Financial Officer | Jan 3, 2025 | Jan 7, 2025 | A · derivative | 59,000 | $0.00 | $0 | 74,000 | No | Form 4 |
| Elston GeorgeChief Financial Officer | Jan 3, 2025 | Jan 7, 2025 | A · derivative | 117,000 | $8.26 | $966,420 | 117,000 | No | Form 4 |
| Ribeiro RamiroChief Medical Officer | Jan 3, 2025 | Jan 7, 2025 | A · derivative | 59,000 | $0.00 | $0 | 59,000 | No | Form 4 |
| Ribeiro RamiroChief Medical Officer | Jan 3, 2025 | Jan 7, 2025 | A · derivative | 117,000 | $8.26 | $966,420 | 117,000 | No | Form 4 |
| Dicicco Wendy F | Jan 3, 2025 | Jan 7, 2025 | A · derivative | 40,000 | $8.26 | $330,400 | 40,000 | No | Form 4 |
| Duty Stuart | Jan 3, 2025 | Jan 7, 2025 | A · derivative | 40,000 | $8.26 | $330,400 | 40,000 | No | Form 4 |
| Ando Goran | Jan 3, 2025 | Jan 7, 2025 | A · derivative | 41,500 | $8.26 | $342,790 | 41,500 | No | Form 4 |
| Zaderej Karen L. | Jan 3, 2025 | Jan 7, 2025 | A · derivative | 40,000 | $8.26 | $330,400 | 40,000 | No | Form 4 |
| Hassan Fred | Jan 3, 2025 | Jan 7, 2025 | A · derivative | 40,000 | $8.26 | $330,400 | 40,000 | No | Form 4 |
| Hassan Fred | Sep 3, 2024 | Sep 5, 2024 | A · derivative | 60,000 | $8.16 | $489,600 | 60,000 | No | Form 4 |
| Ando Goran | Aug 21, 2024 | Aug 21, 2024 | P | 5,000 | $7.95 | Purchase +$39,750 | 13,150 | No | Form 4 |
| Dicicco Wendy F | Aug 20, 2024 | Aug 21, 2024 | P | 2,567 | $7.79 | Purchase +$19,997 | 9,967 | No | Form 4 |
| Zaderej Karen L. | Aug 19, 2024 | Aug 21, 2024 | P | 12,500 | $7.98 | Purchase +$99,750 | 16,500 | No | Form 4 |
| Lurker Nancy | Aug 16, 2024 | Aug 20, 2024 | P | 3,173 | $7.88 | Purchase +$25,003 | 97,635 | No | Form 4 |
| Lurker Nancy | Jul 26, 2024 | Jul 26, 2024 | G · derivative | 1,558 | $12.90 | $20,098 | not reported | No | Form 4 |
| Lurker Nancy | Jul 26, 2024 | Jul 26, 2024 | G · derivative | 1,558 | $12.90 | $20,098 | 74,800 | No | Form 4 |
| Lurker Nancy | Jul 26, 2024 | Jul 26, 2024 | G · derivative | 26,713 | $13.13 | $350,742 | 31,165 | No | Form 4 |
| Lurker Nancy | Jul 26, 2024 | Jul 26, 2024 | G · derivative | 26,713 | $13.13 | $350,742 | 182,535 | No | Form 4 |
| Lurker Nancy | Jul 26, 2024 | Jul 26, 2024 | G · derivative | 30,000 | $10.13 | $303,900 | 95,000 | No | Form 4 |
| Lurker Nancy | Jul 26, 2024 | Jul 26, 2024 | G · derivative | 30,000 | $10.13 | $303,900 | 145,000 | No | Form 4 |
| Lurker Nancy | Jul 26, 2024 | Jul 26, 2024 | G · derivative | 56,350 | $3.26 | $183,701 | 281,750 | No | Form 4 |
| Lurker Nancy | Jul 26, 2024 | Jul 26, 2024 | G · derivative | 56,350 | $3.26 | $183,701 | 169,050 | No | Form 4 |
| Lurker Nancy | Jul 26, 2024 | Jul 26, 2024 | G · derivative | 16,666 | $9.11 | $151,827 | 50,000 | No | Form 4 |
| Lurker Nancy | Jul 26, 2024 | Jul 26, 2024 | G · derivative | 16,666 | $9.11 | $151,827 | 16,666 | No | Form 4 |
| Guyer David R | Jul 12, 2024 | Jul 16, 2024 | M | 3,250 | $3.50 | $11,375 | 6,950 | Yes | Form 4 |
| Guyer David R | Jul 12, 2024 | Jul 16, 2024 | M | 6,525 | $3.26 | $21,272 | 13,475 | Yes | Form 4 |
| Guyer David R | Jul 12, 2024 | Jul 16, 2024 | S | 11,625 | $10.06 | Sale −$116,948 | 1,850 | Yes | Form 4 |
| Guyer David R | Jul 12, 2024 | Jul 16, 2024 | M · derivative | 3,250 | $3.50 | $11,375 | 3,250 | Yes | Form 4 |
| Guyer David R | Jul 12, 2024 | Jul 16, 2024 | M · derivative | 6,525 | $3.26 | $21,272 | 6,525 | Yes | Form 4 |
| Zaderej Karen L. | Jul 11, 2024 | Jul 12, 2024 | M | 2,000 | $0.00 | $0 | 4,000 | No | Form 4 |
| Zaderej Karen L. | Jul 11, 2024 | Jul 12, 2024 | M · derivative | 2,000 | $0.00 | $0 | 2,000 | No | Form 4 |
| Lurker NancyExecutive Vice Chair | Jul 10, 2024 | Jul 12, 2024 | M | 11,111 | $0.00 | $0 | 94,462 | No | Form 4 |
| Lurker NancyExecutive Vice Chair | Jul 10, 2024 | Jul 12, 2024 | M · derivative | 11,111 | $0.00 | $0 | 22,223 | No | Form 4 |
| Duker Jay S.President and CEO | Jul 10, 2024 | Jul 12, 2024 | M | 16,666 | $0.00 | $0 | 46,086 | No | Form 4 |
| Duker Jay S.President and CEO | Jul 10, 2024 | Jul 12, 2024 | F | 8,059 | $8.69 | $70,033 | 38,027 | No | Form 4 |
| Duker Jay S.President and CEO | Jul 10, 2024 | Jul 12, 2024 | M · derivative | 16,666 | $0.00 | $0 | 33,334 | No | Form 4 |
| Adamis Anthony P | Jun 23, 2024 | Jun 25, 2024 | M | 2,000 | $0.00 | $0 | 4,000 | No | Form 4 |
| Adamis Anthony P | Jun 23, 2024 | Jun 25, 2024 | M · derivative | 2,000 | $0.00 | $0 | 2,000 | No | Form 4 |
| Guyer David R | Jun 3, 2024 | Jun 4, 2024 | M | 6,525 | $3.26 | $21,272 | 12,075 | Yes | Form 4 |
| Guyer David R | Jun 3, 2024 | Jun 4, 2024 | M | 3,250 | $3.50 | $11,375 | 15,325 | Yes | Form 4 |
| Guyer David R | Jun 3, 2024 | Jun 4, 2024 | S | 11,625 | $10.30 | Sale −$119,738 | 3,700 | Yes | Form 4 |
| Guyer David R | Jun 3, 2024 | Jun 4, 2024 | M · derivative | 3,250 | $3.50 | $11,375 | 6,500 | Yes | Form 4 |
| Guyer David R | Jun 3, 2024 | Jun 4, 2024 | M · derivative | 6,525 | $3.26 | $21,272 | 13,050 | Yes | Form 4 |
| Elston GeorgeChief Financial Officer | May 25, 2024 | May 28, 2024 | M | 7,500 | $0.00 | $0 | 51,107 | No | Form 4 |
| Elston GeorgeChief Financial Officer | May 25, 2024 | May 28, 2024 | F | 3,627 | $11.16 | $40,477 | 47,480 | No | Form 4 |
| Elston GeorgeChief Financial Officer | May 25, 2024 | May 28, 2024 | M · derivative | 7,500 | $0.00 | $0 | 15,000 | No | Form 4 |
| Guyer David R | May 14, 2024 | May 16, 2024 | M | 6,525 | $3.26 | $21,272 | 13,925 | Yes | Form 4 |
| Guyer David R | May 14, 2024 | May 16, 2024 | M | 3,250 | $3.50 | $11,375 | 17,175 | Yes | Form 4 |
| Guyer David R | May 14, 2024 | May 16, 2024 | S | 11,625 | $12.65 | Sale −$147,056 | 5,550 | Yes | Form 4 |
| Guyer David R | May 14, 2024 | May 16, 2024 | M · derivative | 3,250 | $3.50 | $11,375 | 9,750 | Yes | Form 4 |
| Guyer David R | May 14, 2024 | May 16, 2024 | M · derivative | 6,525 | $3.26 | $21,272 | 19,575 | Yes | Form 4 |
| Cormorant Asset Management, LP | May 6, 2024 | May 8, 2024 | P | 642,847 | $11.70 | Purchase +$7,521,310 | 8,117,847 | No | Form 4 |
| Cormorant Asset Management, LP | May 6, 2024 | May 8, 2024 | P | 207,153 | $12.36 | Purchase +$2,560,411 | 8,325,000 | No | Form 4 |
| Cormorant Global Healthcare Master Fund, LP | Apr 18, 2024 | Apr 22, 2024 | P | 395,244 | $17.62 | Purchase +$6,964,199 | 7,288,479 | No | Form 4 |
| Cormorant Global Healthcare Master Fund, LP | Apr 18, 2024 | Apr 22, 2024 | P | 186,521 | $18.90 | Purchase +$3,525,247 | 7,475,000 | No | Form 4 |
| Paggiarino Dario A.Chief Medical Officer | Mar 30, 2024 | Apr 2, 2024 | M | 5,834 | $0.00 | $0 | 48,056 | No | Form 4 |
| Paggiarino Dario A.Chief Medical Officer | Mar 30, 2024 | Apr 2, 2024 | M | 30,570 | $0.00 | $0 | 78,626 | No | Form 4 |
| Paggiarino Dario A.Chief Medical Officer | Mar 30, 2024 | Apr 2, 2024 | M | 14,000 | $0.00 | $0 | 92,626 | No | Form 4 |
| Paggiarino Dario A.Chief Medical Officer | Mar 30, 2024 | Apr 2, 2024 | F | 15,493 | $20.67 | $320,240 | 77,133 | No | Form 4 |
| Paggiarino Dario A.Chief Medical Officer | Mar 30, 2024 | Apr 2, 2024 | F | 2,957 | $20.67 | $61,121 | 74,176 | No | Form 4 |
| Paggiarino Dario A.Chief Medical Officer | Mar 30, 2024 | Apr 2, 2024 | F | 7,096 | $20.67 | $146,674 | 67,080 | No | Form 4 |
| Paggiarino Dario A.Chief Medical Officer | Mar 30, 2024 | Apr 2, 2024 | M · derivative | 30,570 | $0.00 | $0 | not reported | No | Form 4 |
| Paggiarino Dario A.Chief Medical Officer | Mar 30, 2024 | Apr 2, 2024 | M · derivative | 5,834 | $0.00 | $0 | not reported | No | Form 4 |
| Paggiarino Dario A.Chief Medical Officer | Mar 30, 2024 | Apr 2, 2024 | M · derivative | 14,000 | $0.00 | $0 | not reported | No | Form 4 |
| Ribeiro RamiroChief Medical Officer | Mar 1, 2024 | Mar 4, 2024 | A · derivative | 125,000 | $28.00 | $3,500,000 | 125,000 | No | Form 4 |
| Duker Jay S.President and CEO | Feb 27, 2024 | Feb 28, 2024 | G | 2,500 | $0.00 | $0 | 29,420 | No | Form 4 |
| Duker Jay S.President and CEO | Feb 27, 2024 | Feb 28, 2024 | G | 2,500 | $0.00 | $0 | 22,500 | No | Form 4 |
| Duker Jay S.President and CEO | Feb 20, 2024 | Feb 22, 2024 | G | 20,000 | $0.00 | $0 | 31,920 | No | Form 4 |
| Duker Jay S.President and CEO | Feb 20, 2024 | Feb 22, 2024 | G | 20,000 | $0.00 | $0 | 20,000 | No | Form 4 |
| Lurker NancyExecutive Vice Chair | Feb 13, 2024 | Feb 13, 2024 | G | 74,681 | $0.00 | $0 | 83,351 | No | Form 4 |
| Lurker NancyExecutive Vice Chair | Feb 13, 2024 | Feb 13, 2024 | G | 74,681 | $0.00 | $0 | 126,889 | No | Form 4 |
| Lurker NancyExecutive Vice Chair | Feb 13, 2024 | Feb 13, 2024 | G · derivative | 3,116 | $12.90 | $40,196 | 1,558 | No | Form 4 |
| Lurker NancyExecutive Vice Chair | Feb 13, 2024 | Feb 13, 2024 | G · derivative | 3,116 | $12.90 | $40,196 | 73,242 | No | Form 4 |
| Lurker NancyExecutive Vice Chair | Feb 13, 2024 | Feb 13, 2024 | G · derivative | 4,452 | $13.13 | $58,455 | 57,878 | No | Form 4 |
| Lurker NancyExecutive Vice Chair | Feb 13, 2024 | Feb 13, 2024 | G · derivative | 4,452 | $13.13 | $58,455 | 155,822 | No | Form 4 |
| Lurker NancyExecutive Vice Chair | Feb 13, 2024 | Feb 13, 2024 | G · derivative | 5,000 | $10.13 | $50,650 | 125,000 | No | Form 4 |
| Lurker NancyExecutive Vice Chair | Feb 13, 2024 | Feb 13, 2024 | G · derivative | 5,000 | $10.13 | $50,650 | 115,000 | No | Form 4 |
| Duker Jay S.President and CEO | Feb 9, 2024 | Feb 13, 2024 | M | 7,000 | $0.00 | $0 | 50,486 | No | Form 4 |
| Duker Jay S.President and CEO | Feb 9, 2024 | Feb 13, 2024 | M | 4,967 | $0.00 | $0 | 55,453 | No | Form 4 |
| Duker Jay S.President and CEO | Feb 9, 2024 | Feb 13, 2024 | F | 2,075 | $28.80 | $59,760 | 53,378 | No | Form 4 |
| Duker Jay S.President and CEO | Feb 9, 2024 | Feb 13, 2024 | F | 1,458 | $28.80 | $41,990 | 51,920 | No | Form 4 |
| Duker Jay S.President and CEO | Feb 9, 2024 | Feb 13, 2024 | M · derivative | 4,967 | $0.00 | $0 | not reported | No | Form 4 |
| Duker Jay S.President and CEO | Feb 9, 2024 | Feb 13, 2024 | M · derivative | 7,000 | $0.00 | $0 | 7,000 | No | Form 4 |
| Elston GeorgeChief Financial Officer | Feb 9, 2024 | Feb 13, 2024 | M | 4,967 | $0.00 | $0 | 40,966 | No | Form 4 |
| Elston GeorgeChief Financial Officer | Feb 9, 2024 | Feb 13, 2024 | M | 5,833 | $0.00 | $0 | 46,799 | No | Form 4 |
| Elston GeorgeChief Financial Officer | Feb 9, 2024 | Feb 13, 2024 | F | 1,734 | $28.80 | $49,939 | 45,065 | No | Form 4 |
| Elston GeorgeChief Financial Officer | Feb 9, 2024 | Feb 13, 2024 | F | 1,458 | $28.80 | $41,990 | 43,607 | No | Form 4 |
| Elston GeorgeChief Financial Officer | Feb 9, 2024 | Feb 13, 2024 | M · derivative | 4,967 | $0.00 | $0 | not reported | No | Form 4 |
| Elston GeorgeChief Financial Officer | Feb 9, 2024 | Feb 13, 2024 | M · derivative | 5,833 | $0.00 | $0 | 5,834 | No | Form 4 |
| Jones David ScottSVP & Chief Commercial Officer | Feb 9, 2024 | Feb 13, 2024 | M | 4,967 | $0.00 | $0 | 43,572 | No | Form 4 |
| Jones David ScottSVP & Chief Commercial Officer | Feb 9, 2024 | Feb 13, 2024 | M | 5,000 | $0.00 | $0 | 48,572 | No | Form 4 |
| Jones David ScottSVP & Chief Commercial Officer | Feb 9, 2024 | Feb 13, 2024 | F | 1,955 | $28.80 | $56,304 | 46,617 | No | Form 4 |
| Jones David ScottSVP & Chief Commercial Officer | Feb 9, 2024 | Feb 13, 2024 | F | 1,701 | $28.80 | $48,989 | 44,916 | No | Form 4 |
| Jones David ScottSVP & Chief Commercial Officer | Feb 9, 2024 | Feb 13, 2024 | M · derivative | 4,967 | $0.00 | $0 | not reported | No | Form 4 |
| Jones David ScottSVP & Chief Commercial Officer | Feb 9, 2024 | Feb 13, 2024 | M · derivative | 5,000 | $0.00 | $0 | 5,000 | No | Form 4 |
| Paggiarino Dario A.Chief Medical Officer | Feb 9, 2024 | Feb 13, 2024 | M | 4,967 | $0.00 | $0 | 41,472 | No | Form 4 |
| Paggiarino Dario A.Chief Medical Officer | Feb 9, 2024 | Feb 13, 2024 | M | 5,833 | $0.00 | $0 | 47,305 | No | Form 4 |
| Paggiarino Dario A.Chief Medical Officer | Feb 9, 2024 | Feb 13, 2024 | F | 2,518 | $28.80 | $72,518 | 44,787 | No | Form 4 |
| Paggiarino Dario A.Chief Medical Officer | Feb 9, 2024 | Feb 13, 2024 | F | 2,565 | $28.80 | $73,872 | 42,222 | No | Form 4 |
| Paggiarino Dario A.Chief Medical Officer | Feb 9, 2024 | Feb 13, 2024 | M · derivative | 4,967 | $0.00 | $0 | not reported | No | Form 4 |
| Paggiarino Dario A.Chief Medical Officer | Feb 9, 2024 | Feb 13, 2024 | M · derivative | 5,833 | $0.00 | $0 | 5,834 | No | Form 4 |
| Lurker NancyExecutive Vice Chair | Feb 9, 2024 | Feb 13, 2024 | M | 20,000 | $0.00 | $0 | 155,441 | No | Form 4 |
| Lurker NancyExecutive Vice Chair | Feb 9, 2024 | Feb 13, 2024 | M | 17,534 | $0.00 | $0 | 172,975 | No | Form 4 |
| Lurker NancyExecutive Vice Chair | Feb 9, 2024 | Feb 13, 2024 | F | 7,962 | $28.80 | $229,306 | 165,013 | No | Form 4 |
| Lurker NancyExecutive Vice Chair | Feb 9, 2024 | Feb 13, 2024 | F | 6,981 | $28.80 | $201,053 | 158,032 | No | Form 4 |
| Lurker NancyExecutive Vice Chair | Feb 9, 2024 | Feb 13, 2024 | M · derivative | 17,534 | $0.00 | $0 | not reported | No | Form 4 |
| Lurker NancyExecutive Vice Chair | Feb 9, 2024 | Feb 13, 2024 | M · derivative | 20,000 | $0.00 | $0 | 20,000 | No | Form 4 |
| Jones David ScottSVP & Chief Commercial Officer | Feb 2, 2024 | Feb 5, 2024 | M | 209 | $11.47 | $2,397 | 38,171 | Yes | Form 4 |
| Jones David ScottSVP & Chief Commercial Officer | Feb 2, 2024 | Feb 5, 2024 | S | 209 | $28.49 | Sale −$5,954 | 37,962 | Yes | Form 4 |
| Jones David ScottSVP & Chief Commercial Officer | Feb 2, 2024 | Feb 5, 2024 | M · derivative | 209 | $11.47 | $2,397 | 4,375 | Yes | Form 4 |
| Paggiarino Dario A.Chief Medical Officer | Jan 26, 2024 | Jan 30, 2024 | M | 15,609 | $12.90 | $201,356 | 52,114 | Yes | Form 4 |
| Paggiarino Dario A.Chief Medical Officer | Jan 26, 2024 | Jan 30, 2024 | M | 51 | $13.13 | $670 | 52,165 | Yes | Form 4 |
| Paggiarino Dario A.Chief Medical Officer | Jan 26, 2024 | Jan 30, 2024 | M | 33,665 | $13.13 | $442,021 | 85,830 | Yes | Form 4 |
| Paggiarino Dario A.Chief Medical Officer | Jan 26, 2024 | Jan 30, 2024 | S | 51 | $25.41 | Sale −$1,296 | 85,779 | Yes | Form 4 |
| Paggiarino Dario A.Chief Medical Officer | Jan 26, 2024 | Jan 30, 2024 | S | 15,609 | $25.41 | Sale −$396,625 | 70,170 | Yes | Form 4 |
| Paggiarino Dario A.Chief Medical Officer | Jan 26, 2024 | Jan 30, 2024 | S | 33,665 | $25.77 | Sale −$867,547 | 36,505 | Yes | Form 4 |
| Paggiarino Dario A.Chief Medical Officer | Jan 26, 2024 | Jan 30, 2024 | M · derivative | 51 | $13.13 | $670 | 51,253 | Yes | Form 4 |
| Paggiarino Dario A.Chief Medical Officer | Jan 26, 2024 | Jan 30, 2024 | M · derivative | 33,665 | $13.13 | $442,021 | 17,588 | Yes | Form 4 |
| Paggiarino Dario A.Chief Medical Officer | Jan 26, 2024 | Jan 30, 2024 | M · derivative | 15,609 | $12.90 | $201,356 | 1,026 | Yes | Form 4 |
| Jones David ScottSVP & Chief Commercial Officer | Jan 26, 2024 | Jan 29, 2024 | M | 9,604 | $12.90 | $123,892 | 47,566 | Yes | Form 4 |
| Jones David ScottSVP & Chief Commercial Officer | Jan 26, 2024 | Jan 29, 2024 | M | 16,413 | $3.26 | $53,506 | 63,979 | Yes | Form 4 |
| Jones David ScottSVP & Chief Commercial Officer | Jan 26, 2024 | Jan 29, 2024 | S | 16,413 | $25.45 | Sale −$417,711 | 47,566 | Yes | Form 4 |
| Jones David ScottSVP & Chief Commercial Officer | Jan 26, 2024 | Jan 29, 2024 | S | 9,604 | $25.27 | Sale −$242,693 | 37,962 | Yes | Form 4 |
| Jones David ScottSVP & Chief Commercial Officer | Jan 26, 2024 | Jan 29, 2024 | M · derivative | 9,604 | $12.90 | $123,892 | 8,721 | Yes | Form 4 |
| Jones David ScottSVP & Chief Commercial Officer | Jan 26, 2024 | Jan 29, 2024 | M · derivative | 16,413 | $3.26 | $53,506 | 68,742 | Yes | Form 4 |
| Paggiarino Dario A.Chief Medical Officer | Jan 25, 2024 | Jan 29, 2024 | M | 300 | $13.13 | $3,939 | 36,805 | Yes | Form 4 |
| Paggiarino Dario A.Chief Medical Officer | Jan 25, 2024 | Jan 29, 2024 | M | 300 | $12.90 | $3,870 | 37,105 | Yes | Form 4 |
| Paggiarino Dario A.Chief Medical Officer | Jan 25, 2024 | Jan 29, 2024 | S | 300 | $25.00 | Sale −$7,500 | 36,805 | Yes | Form 4 |
| Paggiarino Dario A.Chief Medical Officer | Jan 25, 2024 | Jan 29, 2024 | S | 300 | $25.00 | Sale −$7,500 | 36,505 | Yes | Form 4 |
| Paggiarino Dario A.Chief Medical Officer | Jan 25, 2024 | Jan 29, 2024 | M · derivative | 300 | $13.13 | $3,939 | 51,304 | Yes | Form 4 |
| Paggiarino Dario A.Chief Medical Officer | Jan 25, 2024 | Jan 29, 2024 | M · derivative | 300 | $12.90 | $3,870 | 16,635 | Yes | Form 4 |
| Jones David ScottSVP & Chief Commercial Officer | Jan 25, 2024 | Jan 26, 2024 | M | 300 | $12.90 | $3,870 | 38,262 | Yes | Form 4 |
| Jones David ScottSVP & Chief Commercial Officer | Jan 25, 2024 | Jan 26, 2024 | M | 300 | $3.26 | $978 | 38,562 | Yes | Form 4 |
| Jones David ScottSVP & Chief Commercial Officer | Jan 25, 2024 | Jan 26, 2024 | S | 300 | $25.00 | Sale −$7,500 | 38,262 | Yes | Form 4 |
| Jones David ScottSVP & Chief Commercial Officer | Jan 25, 2024 | Jan 26, 2024 | S | 300 | $25.00 | Sale −$7,500 | 37,962 | Yes | Form 4 |
| Jones David ScottSVP & Chief Commercial Officer | Jan 25, 2024 | Jan 26, 2024 | M · derivative | 300 | $12.90 | $3,870 | 18,325 | Yes | Form 4 |
| Jones David ScottSVP & Chief Commercial Officer | Jan 25, 2024 | Jan 26, 2024 | M · derivative | 300 | $3.26 | $978 | 85,155 | Yes | Form 4 |
| Jones David ScottSVP & Chief Commercial Officer | Jan 24, 2024 | Jan 26, 2024 | M | 5,600 | $12.90 | $72,240 | 43,562 | Yes | Form 4 |
| Jones David ScottSVP & Chief Commercial Officer | Jan 24, 2024 | Jan 26, 2024 | M | 5,700 | $3.26 | $18,582 | 49,262 | Yes | Form 4 |
| Jones David ScottSVP & Chief Commercial Officer | Jan 24, 2024 | Jan 26, 2024 | S | 5,700 | $25.01 | Sale −$142,557 | 43,562 | Yes | Form 4 |
| Jones David ScottSVP & Chief Commercial Officer | Jan 24, 2024 | Jan 26, 2024 | S | 5,600 | $25.01 | Sale −$140,056 | 37,962 | Yes | Form 4 |
| Jones David ScottSVP & Chief Commercial Officer | Jan 24, 2024 | Jan 26, 2024 | M · derivative | 5,600 | $12.90 | $72,240 | 18,625 | Yes | Form 4 |
| Jones David ScottSVP & Chief Commercial Officer | Jan 24, 2024 | Jan 26, 2024 | M · derivative | 5,700 | $3.26 | $18,582 | 85,455 | Yes | Form 4 |
| Lurker NancyExecutive Vice Chair | Jan 24, 2024 | Jan 25, 2024 | S | 29,956 | $24.98 | Sale −$748,301 | 135,441 | Yes | Form 4 |
| Lurker NancyExecutive Vice Chair | Jan 24, 2024 | Jan 25, 2024 | G · derivative | 112,700 | $3.26 | $367,402 | 338,100 | Yes | Form 4 |
| Lurker NancyExecutive Vice Chair | Jan 24, 2024 | Jan 25, 2024 | G · derivative | 112,700 | $3.26 | $367,402 | 112,700 | Yes | Form 4 |
| Paggiarino Dario A.Chief Medical Officer | Jan 24, 2024 | Jan 25, 2024 | M | 5,651 | $12.90 | $72,898 | 42,156 | No | Form 4 |
| Paggiarino Dario A.Chief Medical Officer | Jan 24, 2024 | Jan 25, 2024 | M | 5,600 | $13.13 | $73,528 | 47,756 | No | Form 4 |
| Paggiarino Dario A.Chief Medical Officer | Jan 24, 2024 | Jan 25, 2024 | S | 5,600 | $25.01 | Sale −$140,056 | 42,156 | No | Form 4 |
| Paggiarino Dario A.Chief Medical Officer | Jan 24, 2024 | Jan 25, 2024 | S | 5,651 | $25.02 | Sale −$141,388 | 36,505 | No | Form 4 |
| Paggiarino Dario A.Chief Medical Officer | Jan 24, 2024 | Jan 25, 2024 | M · derivative | 5,600 | $13.13 | $73,528 | 51,604 | No | Form 4 |
| Paggiarino Dario A.Chief Medical Officer | Jan 24, 2024 | Jan 25, 2024 | M · derivative | 5,651 | $12.90 | $72,898 | 16,935 | No | Form 4 |
| Lurker NancyExecutive Vice Chair | Jan 23, 2024 | Jan 25, 2024 | S | 5,044 | $24.97 | Sale −$125,949 | 165,397 | Yes | Form 4 |
| Paggiarino Dario A.Chief Medical Officer | Jan 23, 2024 | Jan 25, 2024 | M | 3,096 | $13.13 | $40,650 | 39,601 | No | Form 4 |
| Paggiarino Dario A.Chief Medical Officer | Jan 23, 2024 | Jan 25, 2024 | M | 2,039 | $12.90 | $26,303 | 41,640 | No | Form 4 |
| Paggiarino Dario A.Chief Medical Officer | Jan 23, 2024 | Jan 25, 2024 | S | 2,039 | $25.00 | Sale −$50,975 | 39,601 | No | Form 4 |
| Paggiarino Dario A.Chief Medical Officer | Jan 23, 2024 | Jan 25, 2024 | S | 3,096 | $25.00 | Sale −$77,400 | 36,505 | No | Form 4 |
| Paggiarino Dario A.Chief Medical Officer | Jan 23, 2024 | Jan 25, 2024 | M · derivative | 3,096 | $13.13 | $40,650 | 57,204 | No | Form 4 |
| Paggiarino Dario A.Chief Medical Officer | Jan 23, 2024 | Jan 25, 2024 | M · derivative | 2,039 | $12.90 | $26,303 | 22,586 | No | Form 4 |
| Jones David ScottSVP & Chief Commercial Officer | Jan 23, 2024 | Jan 24, 2024 | M | 400 | $12.90 | $5,160 | 38,362 | No | Form 4 |
| Jones David ScottSVP & Chief Commercial Officer | Jan 23, 2024 | Jan 24, 2024 | M | 500 | $3.26 | $1,630 | 38,862 | No | Form 4 |
| Jones David ScottSVP & Chief Commercial Officer | Jan 23, 2024 | Jan 24, 2024 | S | 400 | $25.00 | Sale −$10,000 | 38,462 | No | Form 4 |
| Jones David ScottSVP & Chief Commercial Officer | Jan 23, 2024 | Jan 24, 2024 | S | 500 | $25.00 | Sale −$12,500 | 37,962 | No | Form 4 |
| Jones David ScottSVP & Chief Commercial Officer | Jan 23, 2024 | Jan 24, 2024 | M · derivative | 400 | $12.90 | $5,160 | 24,225 | No | Form 4 |
| Jones David ScottSVP & Chief Commercial Officer | Jan 23, 2024 | Jan 24, 2024 | M · derivative | 500 | $3.26 | $1,630 | 91,155 | No | Form 4 |
| Jones David ScottSVP & Chief Commercial Officer | Jan 22, 2024 | Jan 24, 2024 | M | 28,750 | $10.13 | $291,238 | 66,712 | No | Form 4 |
| Jones David ScottSVP & Chief Commercial Officer | Jan 22, 2024 | Jan 24, 2024 | M | 5,416 | $11.47 | $62,122 | 72,128 | No | Form 4 |
| Jones David ScottSVP & Chief Commercial Officer | Jan 22, 2024 | Jan 24, 2024 | S | 5,416 | $22.24 | Sale −$120,452 | 66,712 | No | Form 4 |
| Jones David ScottSVP & Chief Commercial Officer | Jan 22, 2024 | Jan 24, 2024 | S | 28,750 | $22.69 | Sale −$652,338 | 37,962 | No | Form 4 |
| Jones David ScottSVP & Chief Commercial Officer | Jan 22, 2024 | Jan 24, 2024 | M · derivative | 5,416 | $11.47 | $62,122 | 4,584 | No | Form 4 |
| Jones David ScottSVP & Chief Commercial Officer | Jan 22, 2024 | Jan 24, 2024 | M · derivative | 28,750 | $10.13 | $291,238 | 31,250 | No | Form 4 |
| Liu Ye | Jan 11, 2024 | Jan 16, 2024 | S | 1,910,500 | $19.45 | Sale −$37,159,225 | 100,221 | No | Form 4 |
| Ocumension Therapeutics | Jan 11, 2024 | Jan 16, 2024 | S | 1,910,500 | $19.45 | Sale −$37,159,225 | 100,221 | No | Form 4 |
| Cormorant Asset Management, LP | Jan 11, 2024 | Jan 11, 2024 | P | 750,000 | $19.75 | Purchase +$14,812,500 | 6,893,235 | No | Form 4 |
| Cormorant Asset Management, LP | Jan 9, 2024 | Jan 11, 2024 | P | 105,000 | $21.32 | Purchase +$2,238,600 | 6,143,235 | No | Form 4 |
| Paggiarino Dario A.Chief Medical Officer | Jan 8, 2024 | Jan 10, 2024 | M | 22,913 | $3.26 | $74,696 | 59,418 | Yes | Form 4 |
| Paggiarino Dario A.Chief Medical Officer | Jan 8, 2024 | Jan 10, 2024 | S | 22,913 | $21.13 | Sale −$484,152 | 36,505 | Yes | Form 4 |
| Paggiarino Dario A.Chief Medical Officer | Jan 8, 2024 | Jan 10, 2024 | M · derivative | 22,913 | $3.26 | $74,696 | 68,742 | Yes | Form 4 |
| Elston GeorgeChief Financial Officer | Jan 6, 2024 | Jan 9, 2024 | M | 15,285 | $0.00 | $0 | 40,219 | No | Form 4 |
| Elston GeorgeChief Financial Officer | Jan 6, 2024 | Jan 9, 2024 | F | 4,911 | $20.40 | $100,184 | 35,308 | No | Form 4 |
| Elston GeorgeChief Financial Officer | Jan 6, 2024 | Jan 9, 2024 | M · derivative | 15,285 | $0.00 | $0 | 30,570 | No | Form 4 |
| Duker Jay S.President and CEO | Jan 6, 2024 | Jan 9, 2024 | M | 20,793 | $0.00 | $0 | 50,014 | No | Form 4 |
| Duker Jay S.President and CEO | Jan 6, 2024 | Jan 9, 2024 | F | 6,528 | $20.40 | $133,171 | 43,486 | No | Form 4 |
| Duker Jay S.President and CEO | Jan 6, 2024 | Jan 9, 2024 | M · derivative | 20,793 | $0.00 | $0 | 41,587 | No | Form 4 |
| Jones David ScottSVP & Chief Commercial Officer | Jan 6, 2024 | Jan 9, 2024 | M | 15,285 | $0.00 | $0 | 42,109 | No | Form 4 |
| Jones David ScottSVP & Chief Commercial Officer | Jan 6, 2024 | Jan 9, 2024 | F | 4,147 | $20.40 | $84,599 | 37,962 | No | Form 4 |
| Jones David ScottSVP & Chief Commercial Officer | Jan 6, 2024 | Jan 9, 2024 | M · derivative | 15,285 | $0.00 | $0 | 30,570 | No | Form 4 |
| Pine Michael CraigChief Corp Dev.&Strat. Officer | Jan 6, 2024 | Jan 9, 2024 | M | 15,285 | $0.00 | $0 | 19,628 | No | Form 4 |
| Pine Michael CraigChief Corp Dev.&Strat. Officer | Jan 6, 2024 | Jan 9, 2024 | F | 5,966 | $20.40 | $121,706 | 13,662 | No | Form 4 |
| Pine Michael CraigChief Corp Dev.&Strat. Officer | Jan 6, 2024 | Jan 9, 2024 | M · derivative | 15,285 | $0.00 | $0 | 30,570 | No | Form 4 |
| Lurker NancyExecutive Vice Chair | Jan 6, 2024 | Jan 9, 2024 | M | 75,133 | $0.00 | $0 | 193,484 | No | Form 4 |
| Lurker NancyExecutive Vice Chair | Jan 6, 2024 | Jan 9, 2024 | F | 23,043 | $20.40 | $470,077 | 170,441 | No | Form 4 |
| Lurker NancyExecutive Vice Chair | Jan 6, 2024 | Jan 9, 2024 | M · derivative | 75,133 | $0.00 | $0 | 150,267 | No | Form 4 |
| Paggiarino Dario A.Chief Medical Officer | Jan 6, 2024 | Jan 9, 2024 | M | 15,285 | $0.00 | $0 | 40,992 | No | Form 4 |
| Paggiarino Dario A.Chief Medical Officer | Jan 6, 2024 | Jan 9, 2024 | F | 4,487 | $20.40 | $91,535 | 36,505 | No | Form 4 |
| Paggiarino Dario A.Chief Medical Officer | Jan 6, 2024 | Jan 9, 2024 | M · derivative | 15,285 | $0.00 | $0 | 30,570 | No | Form 4 |
| Adamis Anthony P | Jan 5, 2024 | Jan 9, 2024 | A · derivative | 25,014 | $20.40 | $510,286 | 25,014 | No | Form 4 |
| Ando Goran | Jan 5, 2024 | Jan 9, 2024 | A · derivative | 23,598 | $20.40 | $481,399 | 23,598 | No | Form 4 |
| Dicicco Wendy F | Jan 5, 2024 | Jan 9, 2024 | A · derivative | 25,014 | $20.40 | $510,286 | 25,014 | No | Form 4 |
| Duty Stuart | Jan 5, 2024 | Jan 9, 2024 | A · derivative | 25,014 | $20.40 | $510,286 | 25,014 | No | Form 4 |
| Landis John B. | Jan 5, 2024 | Jan 9, 2024 | A · derivative | 10,000 | $0.00 | $0 | 10,000 | No | Form 4 |
| Landis John B. | Jan 5, 2024 | Jan 9, 2024 | A · derivative | 20,000 | $20.40 | $408,000 | 20,000 | No | Form 4 |
| Landis John B. | Jan 5, 2024 | Jan 9, 2024 | A · derivative | 25,014 | $20.40 | $510,286 | 25,014 | No | Form 4 |
| Guyer David R | Jan 5, 2024 | Jan 9, 2024 | A · derivative | 25,014 | $20.40 | $510,286 | 25,014 | No | Form 4 |
| Elston GeorgeChief Financial Officer | Jan 5, 2024 | Jan 9, 2024 | A · derivative | 45,000 | $0.00 | $0 | 45,000 | No | Form 4 |
| Elston GeorgeChief Financial Officer | Jan 5, 2024 | Jan 9, 2024 | A · derivative | 90,000 | $20.40 | $1,836,000 | 90,000 | No | Form 4 |
| Duker Jay S.President and CEO | Jan 5, 2024 | Jan 9, 2024 | A · derivative | 90,000 | $0.00 | $0 | 90,000 | No | Form 4 |
| Duker Jay S.President and CEO | Jan 5, 2024 | Jan 9, 2024 | A · derivative | 180,000 | $20.40 | $3,672,000 | 180,000 | No | Form 4 |
| Jones David ScottSVP & Chief Commercial Officer | Jan 5, 2024 | Jan 9, 2024 | A · derivative | 21,000 | $0.00 | $0 | 21,000 | No | Form 4 |
| Jones David ScottSVP & Chief Commercial Officer | Jan 5, 2024 | Jan 9, 2024 | A · derivative | 42,000 | $20.40 | $856,800 | 42,000 | No | Form 4 |
| Pine Michael CraigChief Corp Dev.&Strat. Officer | Jan 5, 2024 | Jan 9, 2024 | A · derivative | 21,000 | $0.00 | $0 | 21,000 | No | Form 4 |
| Pine Michael CraigChief Corp Dev.&Strat. Officer | Jan 5, 2024 | Jan 9, 2024 | A · derivative | 42,000 | $20.40 | $856,800 | 42,000 | No | Form 4 |
| Zaderej Karen L. | Jan 5, 2024 | Jan 9, 2024 | A · derivative | 25,014 | $20.40 | $510,286 | 25,014 | No | Form 4 |
| Lurker NancyExecutive Vice Chair | Jan 5, 2024 | Jan 9, 2024 | A · derivative | 38,000 | $0.00 | $0 | 38,000 | No | Form 4 |
| Lurker NancyExecutive Vice Chair | Jan 5, 2024 | Jan 9, 2024 | A · derivative | 77,000 | $20.40 | $1,570,800 | 77,000 | No | Form 4 |
| Paggiarino Dario A.Chief Medical Officer | Jan 5, 2024 | Jan 9, 2024 | A · derivative | 21,000 | $0.00 | $0 | 21,000 | No | Form 4 |
| Paggiarino Dario A.Chief Medical Officer | Jan 5, 2024 | Jan 9, 2024 | A · derivative | 42,000 | $20.40 | $856,800 | 42,000 | No | Form 4 |
| Lurker NancyExecutive Vice Chair | Dec 28, 2023 | Jan 3, 20244/A | G | 52,208 | $0.00 | $0 | 118,351 | No | Form 4/A |
| Lurker NancyExecutive Vice Chair | Dec 28, 2023 | Jan 3, 20244/A | G | 52,208 | $0.00 | $0 | 52,208 | No | Form 4/A |
| Lurker NancyExecutive Vice Chair | Dec 28, 2023 | Jan 3, 20244/A | G · derivative | 31,164 | $13.13 | $409,183 | 62,330 | No | Form 4/A |
| Lurker NancyExecutive Vice Chair | Dec 28, 2023 | Jan 3, 20244/A | G · derivative | 31,164 | $13.13 | $409,183 | 151,370 | No | Form 4/A |
| Lurker NancyExecutive Vice Chair | Dec 28, 2023 | Jan 3, 20244/A | G · derivative | 10,906 | $12.90 | $140,687 | 4,674 | No | Form 4/A |
| Lurker NancyExecutive Vice Chair | Dec 28, 2023 | Jan 3, 20244/A | G · derivative | 10,906 | $12.90 | $140,687 | 70,126 | No | Form 4/A |
| Lurker NancyExecutive Vice Chair | Dec 28, 2023 | Jan 3, 20244/A | G · derivative | 35,000 | $10.13 | $354,550 | 130,000 | No | Form 4/A |
| Lurker NancyExecutive Vice Chair | Dec 28, 2023 | Jan 3, 20244/A | G · derivative | 35,000 | $10.13 | $354,550 | 110,000 | No | Form 4/A |
| Paggiarino Dario A.Chief Medical Officer | Dec 13, 2023 | Dec 15, 2023 | M | 1,458 | $10.13 | $14,770 | 27,165 | Yes | Form 4 |
| Paggiarino Dario A.Chief Medical Officer | Dec 13, 2023 | Dec 15, 2023 | S | 1,458 | $20.00 | Sale −$29,160 | 25,707 | Yes | Form 4 |
| Paggiarino Dario A.Chief Medical Officer | Dec 13, 2023 | Dec 15, 2023 | M · derivative | 1,458 | $10.13 | $14,770 | 37,917 | Yes | Form 4 |
| Cormorant Asset Management, LP | Dec 8, 2023 | Dec 12, 2023 | P | 588,235 | $17.00 | Purchase +$9,999,995 | 6,038,235 | No | Form 4 |
| Pine Michael CraigChief Corp Dev.&Strat. Officer | Dec 4, 2023 | Dec 11, 20234/A | M | 45,000 | $12.62 | $567,900 | 50,343 | Yes | Form 4/A |
| Pine Michael CraigChief Corp Dev.&Strat. Officer | Dec 4, 2023 | Dec 11, 20234/A | S | 45,000 | $22.00 | Sale −$990,000 | 5,343 | Yes | Form 4/A |
| Pine Michael CraigChief Corp Dev.&Strat. Officer | Dec 4, 2023 | Dec 11, 20234/A | S | 1,000 | $20.79 | Sale −$20,790 | 4,343 | Yes | Form 4/A |
| Pine Michael CraigChief Corp Dev.&Strat. Officer | Dec 4, 2023 | Dec 11, 20234/A | M · derivative | 45,000 | $12.62 | $567,900 | 55,000 | Yes | Form 4/A |
| Liu Ye | Dec 6, 2023 | Dec 7, 2023 | S | 266,242 | $18.41 | Sale −$4,901,515 | 2,010,721 | No | Form 4 |
| Ocumension Therapeutics | Dec 6, 2023 | Dec 7, 2023 | S | 266,242 | $18.41 | Sale −$4,901,515 | 2,010,721 | No | Form 4 |
| Liu Ye | Dec 5, 2023 | Dec 7, 2023 | S | 733,758 | $19.91 | Sale −$14,609,122 | 2,276,963 | No | Form 4 |
| Ocumension Therapeutics | Dec 5, 2023 | Dec 7, 2023 | S | 733,758 | $19.91 | Sale −$14,609,122 | 2,276,963 | No | Form 4 |
| Cormorant Global Healthcare Master Fund, LP | Dec 4, 2023 | Dec 6, 2023 | P | 321,259 | $18.80 | Purchase +$6,039,669 | 3,852,202 | No | Form 4 |
| Cormorant Global Healthcare Master Fund, LP | Dec 4, 2023 | Dec 6, 2023 | P | 945,664 | $19.88 | Purchase +$18,799,800 | 4,797,866 | No | Form 4 |
| Cormorant Global Healthcare Master Fund, LP | Dec 4, 2023 | Dec 6, 2023 | P | 122,625 | $20.62 | Purchase +$2,528,528 | 4,920,491 | No | Form 4 |
| Cormorant Global Healthcare Master Fund, LP | Dec 4, 2023 | Dec 6, 2023 | P | 79,805 | $21.87 | Purchase +$1,745,335 | 5,000,296 | No | Form 4 |
| Cormorant Global Healthcare Master Fund, LP | Dec 4, 2023 | Dec 6, 2023 | P | 28,090 | $22.80 | Purchase +$640,452 | 5,028,386 | No | Form 4 |
| Cormorant Global Healthcare Master Fund, LP | Dec 4, 2023 | Dec 6, 2023 | P | 37,081 | $24.01 | Purchase +$890,315 | 5,065,467 | No | Form 4 |
| Cormorant Global Healthcare Master Fund, LP | Dec 4, 2023 | Dec 6, 2023 | P | 39,899 | $24.87 | Purchase +$992,288 | 5,105,366 | No | Form 4 |
| Cormorant Global Healthcare Master Fund, LP | Dec 4, 2023 | Dec 6, 2023 | P | 65,086 | $25.88 | Purchase +$1,684,426 | 5,170,452 | No | Form 4 |
| Cormorant Global Healthcare Master Fund, LP | Dec 4, 2023 | Dec 6, 2023 | P | 53,109 | $26.73 | Purchase +$1,419,604 | 5,223,561 | No | Form 4 |
| Cormorant Global Healthcare Master Fund, LP | Dec 4, 2023 | Dec 6, 2023 | P | 27,425 | $27.87 | Purchase +$764,335 | 5,250,986 | No | Form 4 |
| Cormorant Global Healthcare Master Fund, LP | Dec 4, 2023 | Dec 6, 2023 | P | 8,168 | $28.78 | Purchase +$235,075 | 5,259,154 | No | Form 4 |
| Cormorant Global Healthcare Master Fund, LP | Dec 4, 2023 | Dec 6, 2023 | P | 18,601 | $29.91 | Purchase +$556,356 | 5,277,755 | No | Form 4 |
| Cormorant Global Healthcare Master Fund, LP | Dec 4, 2023 | Dec 6, 2023 | P | 15,582 | $30.74 | Purchase +$478,991 | 5,293,337 | No | Form 4 |
| Cormorant Global Healthcare Master Fund, LP | Dec 4, 2023 | Dec 6, 2023 | P | 86,713 | $31.83 | Purchase +$2,760,075 | 5,380,050 | No | Form 4 |
| Cormorant Global Healthcare Master Fund, LP | Dec 4, 2023 | Dec 6, 2023 | P | 41,824 | $33.08 | Purchase +$1,383,538 | 5,421,874 | No | Form 4 |
| Cormorant Global Healthcare Master Fund, LP | Dec 4, 2023 | Dec 6, 2023 | P | 19,866 | $33.75 | Purchase +$670,478 | 5,441,740 | No | Form 4 |
| Cormorant Global Healthcare Master Fund, LP | Dec 4, 2023 | Dec 6, 2023 | P | 8,260 | $34.49 | Purchase +$284,887 | 5,450,000 | No | Form 4 |
| Lurker NancyExecutive Vice Chair | Dec 4, 2023 | Dec 6, 2023 | S | 20,000 | $20.76 | Sale −$415,200 | 170,559 | Yes | Form 4 |
| Paggiarino Dario A.Chief Medical Officer | Dec 4, 2023 | Dec 6, 2023 | M | 30,625 | $10.13 | $310,231 | 56,332 | Yes | Form 4 |
| Paggiarino Dario A.Chief Medical Officer | Dec 4, 2023 | Dec 6, 2023 | S | 30,625 | $22.00 | Sale −$673,750 | 25,707 | Yes | Form 4 |
| Paggiarino Dario A.Chief Medical Officer | Dec 4, 2023 | Dec 6, 2023 | M · derivative | 30,625 | $10.13 | $310,231 | 39,375 | Yes | Form 4 |
| Elston GeorgeChief Financial Officer | Oct 16, 2023 | Oct 17, 2023 | A · derivative | 30,000 | $8.23 | $246,900 | 30,000 | No | Form 4 |
| Duty Stuart | Oct 16, 2023 | Oct 17, 2023 | A · derivative | 60,000 | $8.23 | $493,800 | 60,000 | No | Form 4 |