INSMINSMED Inc
- Market cap
- $20.39B
- as of 2026-10-23
- Latest close
- $93.39
- as of 2026-10-23
- Sector
- Healthcare
- as of 2026-10-24
- Industry
- Biotechnology
- as of 2026-10-24
Cluster
No cluster in the last 90 days under the default rule (14d · ≥2 insiders · all roles).
Form 4 historysince 2023-10-31
Showing the latest 500 of 895 transactions.
| Insider | Traded | Filed | Type | Shares | Price | Value | Owned after | 10b5-1 plan | Filing |
|---|---|---|---|---|---|---|---|---|---|
| Koppikar Utpal | Oct 19 | Oct 20 | A | 6,139 | not reported | not reported | 6,139 | No | Form 4 |
| Hudson Paul | Oct 19 | Oct 20 | A | 6,139 | not reported | not reported | 6,139 | No | Form 4 |
| Brennan David R | Sep 9 | Sep 11 | S | 25,000 | $124.00 | Sale −$3,100,000 | 39,238 | No | Form 4 |
| Sharoky Melvin Md | Aug 17 | Aug 19 | S | 5,000 | $127.53 | Sale −$637,650 | not reported | No | Form 4 |
| Adsett RogerChief Operating Officer | Aug 10 | Aug 12 | M | 82,280 | $13.67 | $1,124,768 | 181,024 | No | Form 4 |
| Adsett RogerChief Operating Officer | Aug 10 | Aug 12 | M | 76,600 | $17.16 | $1,314,456 | 257,624 | No | Form 4 |
| Adsett RogerChief Operating Officer | Aug 10 | Aug 12 | M | 80,970 | $30.46 | $2,466,346 | 338,594 | No | Form 4 |
| Adsett RogerChief Operating Officer | Aug 10 | Aug 12 | S | 239,850 | $133.27 | Sale −$31,964,810 | 98,744 | No | Form 4 |
| Adsett RogerChief Operating Officer | Aug 10 | Aug 12 | M · derivative | 82,280 | $13.67 | $1,124,768 | not reported | No | Form 4 |
| Adsett RogerChief Operating Officer | Aug 10 | Aug 12 | M · derivative | 76,600 | $17.16 | $1,314,456 | not reported | No | Form 4 |
| Adsett RogerChief Operating Officer | Aug 10 | Aug 12 | M · derivative | 80,970 | $30.46 | $2,466,346 | not reported | No | Form 4 |
| Flammer Martina M.D.Chief Medical Officer | Aug 6 | Aug 7 | M | 18,278 | $18.95 | $346,368 | 78,764 | Yes | Form 4 |
| Flammer Martina M.D.Chief Medical Officer | Aug 6 | Aug 7 | M | 8,895 | $25.83 | $229,758 | 87,659 | Yes | Form 4 |
| Flammer Martina M.D.Chief Medical Officer | Aug 6 | Aug 7 | S | 8,895 | $127.00 | Sale −$1,129,665 | 78,764 | Yes | Form 4 |
| Flammer Martina M.D.Chief Medical Officer | Aug 6 | Aug 7 | S | 18,278 | $129.40 | Sale −$2,365,173 | 60,486 | Yes | Form 4 |
| Flammer Martina M.D.Chief Medical Officer | Aug 6 | Aug 7 | M · derivative | 18,278 | $18.95 | $346,368 | 36,555 | Yes | Form 4 |
| Flammer Martina M.D.Chief Medical Officer | Aug 6 | Aug 7 | M · derivative | 8,895 | $25.83 | $229,758 | 35,580 | Yes | Form 4 |
| Lewis WilliamChair and CEO | Jul 23 | Jul 24 | M | 6,260 | $30.46 | $190,680 | 265,318 | Yes | Form 4 |
| Lewis WilliamChair and CEO | Jul 23 | Jul 24 | M | 4,440 | $17.16 | $76,190 | 269,758 | Yes | Form 4 |
| Lewis WilliamChair and CEO | Jul 23 | Jul 24 | S | 4,828 | $105.62 | Sale −$509,933 | 264,930 | Yes | Form 4 |
| Lewis WilliamChair and CEO | Jul 23 | Jul 24 | S | 5,872 | $106.43 | Sale −$624,957 | 259,058 | Yes | Form 4 |
| Lewis WilliamChair and CEO | Jul 23 | Jul 24 | M · derivative | 6,260 | $30.46 | $190,680 | not reported | Yes | Form 4 |
| Lewis WilliamChair and CEO | Jul 23 | Jul 24 | M · derivative | 4,440 | $17.16 | $76,190 | not reported | Yes | Form 4 |
| Lewis WilliamChair and CEO | Jul 9 | Jul 10 | M | 6,259 | $30.46 | $190,649 | 265,317 | Yes | Form 4 |
| Lewis WilliamChair and CEO | Jul 9 | Jul 10 | M | 4,440 | $17.16 | $76,190 | 269,757 | Yes | Form 4 |
| Lewis WilliamChair and CEO | Jul 9 | Jul 10 | S | 5,005 | $116.55 | Sale −$583,333 | 264,752 | Yes | Form 4 |
| Lewis WilliamChair and CEO | Jul 9 | Jul 10 | S | 2,335 | $117.62 | Sale −$274,643 | 262,417 | Yes | Form 4 |
| Lewis WilliamChair and CEO | Jul 9 | Jul 10 | S | 3,359 | $118.52 | Sale −$398,109 | 259,058 | Yes | Form 4 |
| Lewis WilliamChair and CEO | Jul 9 | Jul 10 | M · derivative | 6,259 | $30.46 | $190,649 | 6,260 | Yes | Form 4 |
| Lewis WilliamChair and CEO | Jul 9 | Jul 10 | M · derivative | 4,440 | $17.16 | $76,190 | 4,440 | Yes | Form 4 |
| Flammer Martina M.D.Chief Medical Officer | Jul 6 | Jul 8 | M | 7,945 | $29.13 | $231,438 | 68,431 | Yes | Form 4 |
| Flammer Martina M.D.Chief Medical Officer | Jul 6 | Jul 8 | M | 4,357 | $19.74 | $86,007 | 72,788 | Yes | Form 4 |
| Flammer Martina M.D.Chief Medical Officer | Jul 6 | Jul 8 | S | 4,854 | $109.02 | Sale −$529,183 | 67,934 | Yes | Form 4 |
| Flammer Martina M.D.Chief Medical Officer | Jul 6 | Jul 8 | S | 7,448 | $110.60 | Sale −$823,749 | 60,486 | Yes | Form 4 |
| Flammer Martina M.D.Chief Medical Officer | Jul 6 | Jul 8 | M · derivative | 7,945 | $29.13 | $231,438 | 23,835 | Yes | Form 4 |
| Flammer Martina M.D.Chief Medical Officer | Jul 6 | Jul 8 | M · derivative | 4,357 | $19.74 | $86,007 | 4,358 | Yes | Form 4 |
| Lewis WilliamChair and CEO | Jun 25 | Jun 26 | M | 12,518 | $30.46 | $381,298 | 271,435 | Yes | Form 4 |
| Lewis WilliamChair and CEO | Jun 25 | Jun 26 | M | 8,880 | $17.16 | $152,381 | 280,315 | Yes | Form 4 |
| Lewis WilliamChair and CEO | Jun 25 | Jun 26 | S | 12,091 | $102.34 | Sale −$1,237,393 | 268,224 | Yes | Form 4 |
| Lewis WilliamChair and CEO | Jun 25 | Jun 26 | S | 1,836 | $103.10 | Sale −$189,292 | 266,388 | Yes | Form 4 |
| Lewis WilliamChair and CEO | Jun 25 | Jun 26 | S | 3,723 | $104.28 | Sale −$388,234 | 262,665 | Yes | Form 4 |
| Lewis WilliamChair and CEO | Jun 25 | Jun 26 | S | 2,456 | $105.27 | Sale −$258,543 | 260,209 | Yes | Form 4 |
| Lewis WilliamChair and CEO | Jun 25 | Jun 26 | S | 1,292 | $106.27 | Sale −$137,301 | 258,917 | Yes | Form 4 |
| Lewis WilliamChair and CEO | Jun 25 | Jun 26 | M · derivative | 12,518 | $30.46 | $381,298 | 12,519 | Yes | Form 4 |
| Lewis WilliamChair and CEO | Jun 25 | Jun 26 | M · derivative | 8,880 | $17.16 | $152,381 | 8,880 | Yes | Form 4 |
| Butera SamueleSVP, GM, Global Respiratory | Jun 23 | Jun 24 | A | 7,342 | not reported | not reported | 7,342 | No | Form 4 |
| Butera SamueleSVP, GM, Global Respiratory | Jun 23 | Jun 24 | A · derivative | 12,570 | $102.15 | $1,284,026 | 12,570 | No | Form 4 |
| Smith Michael AlexanderChief Legal Officer | Jun 22 | Jun 24 | S | 1,806 | $95.82 | Sale −$173,051 | 37,648 | Yes | Form 4 |
| Lewis WilliamChair and CEO | Jun 8 | Jun 10 | S | 6,515 | $94.03 | Sale −$612,605 | 258,917 | Yes | Form 4 |
| Flammer Martina M.D.Chief Medical Officer | Jun 5 | Jun 5 | S | 1,858 | $103.78 | Sale −$192,823 | 60,486 | Yes | Form 4 |
| Lewis WilliamChair and CEO | Jun 3 | Jun 5 | S | 7,605 | $102.27 | Sale −$777,763 | 265,432 | No | Form 4 |
| Bonstein SaraChief Financial Officer | Jun 3 | Jun 5 | S | 2,404 | $102.27 | Sale −$245,857 | 69,082 | No | Form 4 |
| Adsett RogerChief Operating Officer | Jun 3 | Jun 5 | S | 2,370 | $102.27 | Sale −$242,380 | 98,603 | No | Form 4 |
| Flammer Martina M.D.Chief Medical Officer | Jun 3 | Jun 5 | S | 2,566 | $102.27 | Sale −$262,425 | 62,344 | Yes | Form 4 |
| Smith Michael AlexanderChief Legal Officer | Jun 3 | Jun 5 | S | 2,159 | $102.27 | Sale −$220,801 | 39,454 | No | Form 4 |
| Smith Michael AlexanderChief Legal Officer | May 22 | May 22 | S | 6,149 | $108.47 | Sale −$666,982 | 41,613 | Yes | Form 4 |
| Lewis WilliamChair and CEO | May 18 | May 20 | M | 6,259 | $30.46 | $190,649 | 294,161 | Yes | Form 4 |
| Lewis WilliamChair and CEO | May 18 | May 20 | M | 4,440 | $17.16 | $76,190 | 298,601 | Yes | Form 4 |
| Lewis WilliamChair and CEO | May 18 | May 20 | S | 5,753 | $105.32 | Sale −$605,906 | 292,848 | Yes | Form 4 |
| Lewis WilliamChair and CEO | May 18 | May 20 | S | 11,836 | $106.39 | Sale −$1,259,232 | 281,012 | Yes | Form 4 |
| Lewis WilliamChair and CEO | May 18 | May 20 | S | 7,975 | $106.97 | Sale −$853,086 | 273,037 | Yes | Form 4 |
| Lewis WilliamChair and CEO | May 18 | May 20 | M · derivative | 6,259 | $30.46 | $190,649 | 25,037 | Yes | Form 4 |
| Lewis WilliamChair and CEO | May 18 | May 20 | M · derivative | 4,440 | $17.16 | $76,190 | 17,760 | Yes | Form 4 |
| Flammer Martina M.D.Chief Medical Officer | May 14 | May 15 | S | 10,479 | $117.54 | Sale −$1,231,702 | 64,910 | Yes | Form 4 |
| Sharoky Melvin Md | May 13 | May 15 | A | 3,305 | not reported | not reported | 246,081 | No | Form 4 |
| Schafer Carol | May 13 | May 15 | A | 3,305 | not reported | not reported | 66,622 | No | Form 4 |
| Lewis WilliamChair and CEO | May 13 | May 15 | S | 13,283 | $116.18 | Sale −$1,543,219 | 287,902 | No | Form 4 |
| Bonstein SaraChief Financial Officer | May 13 | May 15 | S | 8,272 | $116.18 | Sale −$961,041 | 71,486 | No | Form 4 |
| Brennan David R | May 13 | May 15 | A | 3,305 | not reported | not reported | 64,238 | No | Form 4 |
| Adsett RogerChief Operating Officer | May 13 | May 15 | S | 5,837 | $116.18 | Sale −$678,143 | 100,973 | No | Form 4 |
| Lee Leo | May 13 | May 15 | A | 3,305 | not reported | not reported | 57,971 | No | Form 4 |
| Anderson Elizabeth M | May 13 | May 15 | A | 3,305 | not reported | not reported | 62,034 | No | Form 4 |
| Desjardins Clarissa | May 13 | May 15 | A | 3,305 | not reported | not reported | 70,312 | No | Form 4 |
| Flammer Martina M.D.Chief Medical Officer | May 13 | May 15 | S | 4,470 | $112.76 | Sale −$504,037 | 78,773 | Yes | Form 4 |
| Flammer Martina M.D.Chief Medical Officer | May 13 | May 15 | S | 3,384 | $116.18 | Sale −$393,153 | 75,389 | Yes | Form 4 |
| Smith Michael AlexanderChief Legal Officer | May 13 | May 15 | S | 4,109 | $116.18 | Sale −$477,384 | 47,762 | No | Form 4 |
| Flammer Martina M.D.Chief Medical Officer | May 11 | May 13 | M | 12,949 | $17.07 | $221,039 | 96,192 | Yes | Form 4 |
| Flammer Martina M.D.Chief Medical Officer | May 11 | May 13 | S | 12,119 | $100.35 | Sale −$1,216,142 | 84,073 | Yes | Form 4 |
| Flammer Martina M.D.Chief Medical Officer | May 11 | May 13 | S | 830 | $101.18 | Sale −$83,979 | 83,243 | Yes | Form 4 |
| Flammer Martina M.D.Chief Medical Officer | May 11 | May 13 | M · derivative | 12,949 | $17.07 | $221,039 | not reported | Yes | Form 4 |
| Lewis WilliamChair and CEO | May 4 | May 6 | M | 6,259 | $30.46 | $190,649 | 307,444 | Yes | Form 4 |
| Lewis WilliamChair and CEO | May 4 | May 6 | M | 4,440 | $17.16 | $76,190 | 311,884 | Yes | Form 4 |
| Lewis WilliamChair and CEO | May 4 | May 6 | S | 433 | $134.18 | Sale −$58,100 | 311,451 | Yes | Form 4 |
| Lewis WilliamChair and CEO | May 4 | May 6 | S | 599 | $135.18 | Sale −$80,973 | 310,852 | Yes | Form 4 |
| Lewis WilliamChair and CEO | May 4 | May 6 | S | 5,318 | $137.01 | Sale −$728,619 | 305,534 | Yes | Form 4 |
| Lewis WilliamChair and CEO | May 4 | May 6 | S | 2,721 | $137.86 | Sale −$375,117 | 302,813 | Yes | Form 4 |
| Lewis WilliamChair and CEO | May 4 | May 6 | S | 1,247 | $139.09 | Sale −$173,445 | 301,566 | Yes | Form 4 |
| Lewis WilliamChair and CEO | May 4 | May 6 | S | 381 | $139.60 | Sale −$53,188 | 301,185 | Yes | Form 4 |
| Lewis WilliamChair and CEO | May 4 | May 6 | M · derivative | 6,259 | $30.46 | $190,649 | 31,296 | Yes | Form 4 |
| Lewis WilliamChair and CEO | May 4 | May 6 | M · derivative | 4,440 | $17.16 | $76,190 | 22,200 | Yes | Form 4 |
| Lewis WilliamChair and CEO | Apr 16 | Apr 17 | M | 6,259 | $30.46 | $190,649 | 307,444 | Yes | Form 4 |
| Lewis WilliamChair and CEO | Apr 16 | Apr 17 | M | 4,440 | $17.16 | $76,190 | 311,884 | Yes | Form 4 |
| Lewis WilliamChair and CEO | Apr 16 | Apr 17 | S | 2,246 | $142.99 | Sale −$321,156 | 309,638 | Yes | Form 4 |
| Lewis WilliamChair and CEO | Apr 16 | Apr 17 | S | 5,373 | $143.81 | Sale −$772,691 | 304,265 | Yes | Form 4 |
| Lewis WilliamChair and CEO | Apr 16 | Apr 17 | S | 2,255 | $144.66 | Sale −$326,208 | 302,010 | Yes | Form 4 |
| Lewis WilliamChair and CEO | Apr 16 | Apr 17 | S | 825 | $145.79 | Sale −$120,277 | 301,185 | Yes | Form 4 |
| Lewis WilliamChair and CEO | Apr 16 | Apr 17 | M · derivative | 6,259 | $30.46 | $190,649 | 37,555 | Yes | Form 4 |
| Lewis WilliamChair and CEO | Apr 16 | Apr 17 | M · derivative | 4,440 | $17.16 | $76,190 | 26,640 | Yes | Form 4 |
| Lewis WilliamChair and CEO | Apr 6 | Apr 8 | M | 6,259 | $30.46 | $190,649 | 307,444 | Yes | Form 4 |
| Lewis WilliamChair and CEO | Apr 6 | Apr 8 | M | 4,440 | $17.16 | $76,190 | 311,884 | Yes | Form 4 |
| Lewis WilliamChair and CEO | Apr 6 | Apr 8 | S | 787 | $161.73 | Sale −$127,282 | 311,097 | Yes | Form 4 |
| Lewis WilliamChair and CEO | Apr 6 | Apr 8 | S | 8,478 | $163.23 | Sale −$1,383,864 | 302,619 | Yes | Form 4 |
| Lewis WilliamChair and CEO | Apr 6 | Apr 8 | S | 1,434 | $164.01 | Sale −$235,190 | 301,185 | Yes | Form 4 |
| Lewis WilliamChair and CEO | Apr 6 | Apr 8 | M · derivative | 6,259 | $30.46 | $190,649 | 43,814 | Yes | Form 4 |
| Lewis WilliamChair and CEO | Apr 6 | Apr 8 | M · derivative | 4,440 | $17.16 | $76,190 | 31,080 | Yes | Form 4 |
| Adsett RogerChief Operating Officer | Apr 1 | Apr 3 | M | 88,060 | $14.56 | $1,282,154 | 194,870 | Yes | Form 4 |
| Adsett RogerChief Operating Officer | Apr 1 | Apr 3 | S | 6,715 | $163.18 | Sale −$1,095,754 | 188,155 | Yes | Form 4 |
| Adsett RogerChief Operating Officer | Apr 1 | Apr 3 | S | 19,001 | $164.11 | Sale −$3,118,254 | 169,154 | Yes | Form 4 |
| Adsett RogerChief Operating Officer | Apr 1 | Apr 3 | S | 62,344 | $164.95 | Sale −$10,283,643 | 106,810 | Yes | Form 4 |
| Adsett RogerChief Operating Officer | Apr 1 | Apr 3 | M · derivative | 88,060 | $14.56 | $1,282,154 | not reported | Yes | Form 4 |
| Smith Michael AlexanderChief Legal Officer | Mar 30 | Mar 31 | M | 5,649 | $17.07 | $96,428 | 57,520 | Yes | Form 4 |
| Smith Michael AlexanderChief Legal Officer | Mar 30 | Mar 31 | M | 13,989 | $27.89 | $390,153 | 71,509 | Yes | Form 4 |
| Smith Michael AlexanderChief Legal Officer | Mar 30 | Mar 31 | S | 19,638 | $150.98 | Sale −$2,964,945 | 51,871 | Yes | Form 4 |
| Smith Michael AlexanderChief Legal Officer | Mar 30 | Mar 31 | M · derivative | 5,649 | $17.07 | $96,428 | 8,633 | Yes | Form 4 |
| Smith Michael AlexanderChief Legal Officer | Mar 30 | Mar 31 | M · derivative | 13,989 | $27.89 | $390,153 | 18,561 | Yes | Form 4 |
| Lewis WilliamChair and CEO | Mar 19 | Mar 20 | M | 6,259 | $30.46 | $190,649 | 307,444 | Yes | Form 4 |
| Lewis WilliamChair and CEO | Mar 19 | Mar 20 | M | 4,440 | $17.16 | $76,190 | 311,884 | Yes | Form 4 |
| Lewis WilliamChair and CEO | Mar 19 | Mar 20 | S | 1,629 | $142.17 | Sale −$231,595 | 310,255 | Yes | Form 4 |
| Lewis WilliamChair and CEO | Mar 19 | Mar 20 | S | 4,537 | $143.42 | Sale −$650,697 | 305,718 | Yes | Form 4 |
| Lewis WilliamChair and CEO | Mar 19 | Mar 20 | S | 4,533 | $144.11 | Sale −$653,251 | 301,185 | Yes | Form 4 |
| Lewis WilliamChair and CEO | Mar 19 | Mar 20 | M · derivative | 6,259 | $30.46 | $190,649 | 50,073 | Yes | Form 4 |
| Lewis WilliamChair and CEO | Mar 19 | Mar 20 | M · derivative | 4,440 | $17.16 | $76,190 | 35,520 | Yes | Form 4 |
| Lewis WilliamChair and CEO | Mar 5 | Mar 5 | M | 6,259 | $30.46 | $190,649 | 307,444 | Yes | Form 4 |
| Lewis WilliamChair and CEO | Mar 5 | Mar 5 | M | 4,440 | $17.16 | $76,190 | 311,884 | Yes | Form 4 |
| Lewis WilliamChair and CEO | Mar 5 | Mar 5 | S | 2,083 | $144.23 | Sale −$300,431 | 309,801 | Yes | Form 4 |
| Lewis WilliamChair and CEO | Mar 5 | Mar 5 | S | 2,589 | $145.27 | Sale −$376,104 | 307,212 | Yes | Form 4 |
| Lewis WilliamChair and CEO | Mar 5 | Mar 5 | S | 3,899 | $146.66 | Sale −$571,827 | 303,313 | Yes | Form 4 |
| Lewis WilliamChair and CEO | Mar 5 | Mar 5 | S | 2,128 | $147.54 | Sale −$313,965 | 301,185 | Yes | Form 4 |
| Lewis WilliamChair and CEO | Mar 5 | Mar 5 | M · derivative | 6,259 | $30.46 | $190,649 | 56,332 | Yes | Form 4 |
| Lewis WilliamChair and CEO | Mar 5 | Mar 5 | M · derivative | 4,440 | $17.16 | $76,190 | 39,960 | Yes | Form 4 |
| Sharoky Melvin Md | Mar 3 | Mar 5 | G | 100 | $0.00 | $0 | 242,776 | No | Form 4 |
| Sharoky Melvin Md | Feb 25 | Feb 27 | G | 1,072 | $0.00 | $0 | 242,876 | No | Form 4 |
| Sharoky Melvin Md | Feb 25 | Feb 27 | G | 243 | $0.00 | $0 | 5,423 | No | Form 4 |
| Sharoky Melvin Md | Feb 25 | Feb 27 | G | 243 | $0.00 | $0 | 3,724 | No | Form 4 |
| Sharoky Melvin Md | Feb 25 | Feb 27 | G | 243 | $0.00 | $0 | 5,007 | No | Form 4 |
| Sharoky Melvin Md | Feb 25 | Feb 27 | G | 243 | $0.00 | $0 | 819 | No | Form 4 |
| Smith Michael AlexanderChief Legal Officer | Feb 24 | Feb 25 | M | 20,248 | $17.07 | $345,633 | 76,645 | Yes | Form 4 |
| Smith Michael AlexanderChief Legal Officer | Feb 24 | Feb 25 | S | 4,852 | $153.93 | Sale −$746,868 | 71,793 | Yes | Form 4 |
| Smith Michael AlexanderChief Legal Officer | Feb 24 | Feb 25 | S | 4,151 | $155.06 | Sale −$643,654 | 67,642 | Yes | Form 4 |
| Smith Michael AlexanderChief Legal Officer | Feb 24 | Feb 25 | S | 15,771 | $156.53 | Sale −$2,468,635 | 51,871 | Yes | Form 4 |
| Smith Michael AlexanderChief Legal Officer | Feb 24 | Feb 25 | M · derivative | 20,248 | $17.07 | $345,633 | 14,282 | Yes | Form 4 |
| Brennan David R | Feb 23 | Feb 25 | G | 6,000 | $0.00 | $0 | 60,933 | No | Form 4 |
| Lewis WilliamChair and CEO | Feb 19 | Feb 23 | M | 6,259 | $30.46 | $190,649 | 307,444 | Yes | Form 4 |
| Lewis WilliamChair and CEO | Feb 19 | Feb 23 | M | 4,440 | $17.16 | $76,190 | 311,884 | Yes | Form 4 |
| Lewis WilliamChair and CEO | Feb 19 | Feb 23 | S | 1,988 | $149.17 | Sale −$296,550 | 309,896 | Yes | Form 4 |
| Lewis WilliamChair and CEO | Feb 19 | Feb 23 | S | 1,891 | $150.10 | Sale −$283,839 | 308,005 | Yes | Form 4 |
| Lewis WilliamChair and CEO | Feb 19 | Feb 23 | S | 3,413 | $151.12 | Sale −$515,773 | 304,592 | Yes | Form 4 |
| Lewis WilliamChair and CEO | Feb 19 | Feb 23 | S | 2,377 | $151.92 | Sale −$361,114 | 302,215 | Yes | Form 4 |
| Lewis WilliamChair and CEO | Feb 19 | Feb 23 | S | 1,030 | $153.38 | Sale −$157,981 | 301,185 | Yes | Form 4 |
| Lewis WilliamChair and CEO | Feb 19 | Feb 23 | M · derivative | 6,259 | $30.46 | $190,649 | 62,591 | Yes | Form 4 |
| Lewis WilliamChair and CEO | Feb 19 | Feb 23 | M · derivative | 4,440 | $17.16 | $76,190 | 44,400 | Yes | Form 4 |
| Mcgirr David W J | Feb 9 | Feb 11 | G | 53,400 | $0.00 | $0 | 44,323 | No | Form 4 |
| Mcgirr David W J | Feb 9 | Feb 11 | G | 53,400 | $0.00 | $0 | 53,400 | No | Form 4 |
| Lewis WilliamChair and CEO | Feb 9 | Feb 11 | M | 4,440 | $17.16 | $76,190 | 308,322 | Yes | Form 4 |
| Lewis WilliamChair and CEO | Feb 9 | Feb 11 | M | 6,259 | $30.46 | $190,649 | 314,581 | Yes | Form 4 |
| Lewis WilliamChair and CEO | Feb 9 | Feb 11 | S | 4,888 | $147.17 | Sale −$719,367 | 309,693 | Yes | Form 4 |
| Lewis WilliamChair and CEO | Feb 9 | Feb 11 | S | 7,221 | $148.02 | Sale −$1,068,852 | 302,472 | Yes | Form 4 |
| Lewis WilliamChair and CEO | Feb 9 | Feb 11 | S | 1,287 | $148.83 | Sale −$191,544 | 301,185 | Yes | Form 4 |
| Lewis WilliamChair and CEO | Feb 9 | Feb 11 | M · derivative | 4,440 | $17.16 | $76,190 | 48,840 | Yes | Form 4 |
| Lewis WilliamChair and CEO | Feb 9 | Feb 11 | M · derivative | 6,259 | $30.46 | $190,649 | 68,850 | Yes | Form 4 |
| Flammer Martina M.D.Chief Medical Officer | Feb 5 | Feb 6 | S | 869 | $152.44 | Sale −$132,470 | 83,243 | Yes | Form 4 |
| Lewis WilliamChair and CEO | Feb 3 | Feb 4 | S | 3,009 | $156.34 | Sale −$470,427 | 303,882 | No | Form 4 |
| Bonstein SaraChief Financial Officer | Feb 3 | Feb 4 | S | 748 | $156.34 | Sale −$116,942 | 79,758 | No | Form 4 |
| Adsett RogerChief Operating Officer | Feb 3 | Feb 4 | S | 791 | $156.17 | Sale −$123,530 | 106,810 | No | Form 4 |
| Flammer Martina M.D.Chief Medical Officer | Feb 3 | Feb 4 | S | 795 | $155.77 | Sale −$123,837 | 84,112 | Yes | Form 4 |
| Smith Michael AlexanderChief Legal Officer | Feb 3 | Feb 4 | S | 640 | $156.27 | Sale −$100,013 | 56,397 | No | Form 4 |
| Flammer Martina M.D.Chief Medical Officer | Feb 2 | Feb 4 | M | 7,982 | $65.72 | $524,577 | 92,889 | Yes | Form 4 |
| Flammer Martina M.D.Chief Medical Officer | Feb 2 | Feb 4 | S | 563 | $152.06 | Sale −$85,610 | 92,326 | Yes | Form 4 |
| Flammer Martina M.D.Chief Medical Officer | Feb 2 | Feb 4 | S | 928 | $153.16 | Sale −$142,132 | 91,398 | Yes | Form 4 |
| Flammer Martina M.D.Chief Medical Officer | Feb 2 | Feb 4 | S | 3,349 | $154.56 | Sale −$517,621 | 88,049 | Yes | Form 4 |
| Flammer Martina M.D.Chief Medical Officer | Feb 2 | Feb 4 | S | 3,042 | $155.46 | Sale −$472,909 | 85,007 | Yes | Form 4 |
| Flammer Martina M.D.Chief Medical Officer | Feb 2 | Feb 4 | S | 100 | $156.86 | Sale −$15,686 | 84,907 | Yes | Form 4 |
| Flammer Martina M.D.Chief Medical Officer | Feb 2 | Feb 4 | M · derivative | 7,982 | $65.72 | $524,577 | 23,948 | Yes | Form 4 |
| Lewis WilliamChair and CEO | Jan 20 | Jan 22 | M | 6,259 | $30.46 | $190,649 | 313,150 | Yes | Form 4 |
| Lewis WilliamChair and CEO | Jan 20 | Jan 22 | M | 4,440 | $17.16 | $76,190 | 317,590 | Yes | Form 4 |
| Lewis WilliamChair and CEO | Jan 20 | Jan 22 | S | 1,006 | $156.80 | Sale −$157,741 | 316,584 | Yes | Form 4 |
| Lewis WilliamChair and CEO | Jan 20 | Jan 22 | S | 1,243 | $158.37 | Sale −$196,854 | 315,341 | Yes | Form 4 |
| Lewis WilliamChair and CEO | Jan 20 | Jan 22 | S | 5,967 | $158.99 | Sale −$948,693 | 309,374 | Yes | Form 4 |
| Lewis WilliamChair and CEO | Jan 20 | Jan 22 | S | 2,229 | $159.85 | Sale −$356,306 | 307,145 | Yes | Form 4 |
| Lewis WilliamChair and CEO | Jan 20 | Jan 22 | S | 254 | $160.70 | Sale −$40,818 | 306,891 | Yes | Form 4 |
| Lewis WilliamChair and CEO | Jan 20 | Jan 22 | M · derivative | 6,259 | $30.46 | $190,649 | 75,109 | Yes | Form 4 |
| Lewis WilliamChair and CEO | Jan 20 | Jan 22 | M · derivative | 4,440 | $17.16 | $76,190 | 53,280 | Yes | Form 4 |
| Lewis WilliamChair and CEO | Jan 12 | Jan 13 | M | 6,259 | $30.46 | $190,649 | 321,666 | Yes | Form 4 |
| Lewis WilliamChair and CEO | Jan 12 | Jan 13 | M | 4,440 | $17.16 | $76,190 | 326,106 | Yes | Form 4 |
| Lewis WilliamChair and CEO | Jan 12 | Jan 13 | S | 3,974 | $167.73 | Sale −$666,559 | 322,132 | Yes | Form 4 |
| Lewis WilliamChair and CEO | Jan 12 | Jan 13 | S | 7,176 | $168.63 | Sale −$1,210,089 | 314,956 | Yes | Form 4 |
| Lewis WilliamChair and CEO | Jan 12 | Jan 13 | S | 6,996 | $169.57 | Sale −$1,186,312 | 307,960 | Yes | Form 4 |
| Lewis WilliamChair and CEO | Jan 12 | Jan 13 | S | 160 | $170.24 | Sale −$27,238 | 307,800 | Yes | Form 4 |
| Lewis WilliamChair and CEO | Jan 12 | Jan 13 | S | 297 | $171.31 | Sale −$50,879 | 307,503 | Yes | Form 4 |
| Lewis WilliamChair and CEO | Jan 12 | Jan 13 | S | 297 | $172.36 | Sale −$51,191 | 307,206 | Yes | Form 4 |
| Lewis WilliamChair and CEO | Jan 12 | Jan 13 | S | 315 | $174.86 | Sale −$55,081 | 306,891 | Yes | Form 4 |
| Lewis WilliamChair and CEO | Jan 12 | Jan 13 | M · derivative | 6,259 | $30.46 | $190,649 | 81,368 | Yes | Form 4 |
| Lewis WilliamChair and CEO | Jan 12 | Jan 13 | M · derivative | 4,440 | $17.16 | $76,190 | 57,720 | Yes | Form 4 |
| Flammer Martina M.D.Chief Medical Officer | Jan 9 | Jan 13 | S | 1,887 | $186.19 | Sale −$351,341 | 84,907 | Yes | Form 4 |
| Lewis WilliamChair and CEO | Jan 8 | Jan 8 | S | 3,223 | $174.17 | Sale −$561,350 | 315,407 | No | Form 4 |
| Bonstein SaraChief Financial Officer | Jan 8 | Jan 8 | S | 1,447 | $174.17 | Sale −$252,024 | 80,506 | No | Form 4 |
| Adsett RogerChief Operating Officer | Jan 8 | Jan 8 | S | 2,059 | $174.17 | Sale −$358,616 | 107,601 | No | Form 4 |
| Flammer Martina M.D.Chief Medical Officer | Jan 8 | Jan 8 | S | 1,660 | $173.87 | Sale −$288,624 | 90,045 | Yes | Form 4 |
| Flammer Martina M.D.Chief Medical Officer | Jan 8 | Jan 8 | S | 3,251 | $174.17 | Sale −$566,227 | 86,794 | Yes | Form 4 |
| Smith Michael AlexanderChief Legal Officer | Jan 8 | Jan 8 | S | 1,053 | $174.17 | Sale −$183,401 | 57,037 | No | Form 4 |
| Lewis WilliamChair and CEO | Jan 7 | Jan 8 | S | 2,357 | $175.07 | Sale −$412,640 | 318,630 | No | Form 4 |
| Bonstein SaraChief Financial Officer | Jan 7 | Jan 8 | S | 1,678 | $175.07 | Sale −$293,767 | 81,953 | No | Form 4 |
| Adsett RogerChief Operating Officer | Jan 7 | Jan 8 | S | 802 | $175.07 | Sale −$140,406 | 109,660 | No | Form 4 |
| Flammer Martina M.D.Chief Medical Officer | Jan 7 | Jan 8 | S | 1,434 | $175.84 | Sale −$252,155 | 91,705 | Yes | Form 4 |
| Smith Michael AlexanderChief Legal Officer | Jan 7 | Jan 8 | S | 709 | $175.07 | Sale −$124,125 | 58,090 | No | Form 4 |
| Lewis WilliamChair and CEO | Jan 6 | Jan 8 | S | 4,096 | $173.33 | Sale −$709,960 | 320,987 | No | Form 4 |
| Bonstein SaraChief Financial Officer | Jan 6 | Jan 8 | S | 1,517 | $173.33 | Sale −$262,942 | 83,631 | No | Form 4 |
| Adsett RogerChief Operating Officer | Jan 6 | Jan 8 | S | 1,429 | $173.33 | Sale −$247,689 | 110,462 | No | Form 4 |
| Flammer Martina M.D.Chief Medical Officer | Jan 6 | Jan 8 | M | 8,570 | $26.43 | $226,505 | 103,324 | Yes | Form 4 |
| Flammer Martina M.D.Chief Medical Officer | Jan 6 | Jan 8 | S | 4,783 | $173.47 | Sale −$829,707 | 98,541 | Yes | Form 4 |
| Flammer Martina M.D.Chief Medical Officer | Jan 6 | Jan 8 | S | 2,830 | $174.21 | Sale −$493,014 | 95,711 | Yes | Form 4 |
| Flammer Martina M.D.Chief Medical Officer | Jan 6 | Jan 8 | S | 957 | $175.01 | Sale −$167,485 | 94,754 | Yes | Form 4 |
| Flammer Martina M.D.Chief Medical Officer | Jan 6 | Jan 8 | S | 1,615 | $173.33 | Sale −$279,928 | 93,139 | Yes | Form 4 |
| Flammer Martina M.D.Chief Medical Officer | Jan 6 | Jan 8 | M · derivative | 8,570 | $26.43 | $226,505 | not reported | Yes | Form 4 |
| Smith Michael AlexanderChief Legal Officer | Jan 6 | Jan 8 | S | 1,396 | $173.33 | Sale −$241,969 | 58,799 | No | Form 4 |
| Flammer Martina M.D.Chief Medical Officer | Jan 5 | Jan 6 | M | 4,358 | $19.74 | $86,027 | 99,112 | Yes | Form 4 |
| Flammer Martina M.D.Chief Medical Officer | Jan 5 | Jan 6 | M | 7,945 | $29.13 | $231,438 | 107,057 | Yes | Form 4 |
| Flammer Martina M.D.Chief Medical Officer | Jan 5 | Jan 6 | S | 2,799 | $169.29 | Sale −$473,843 | 104,258 | Yes | Form 4 |
| Flammer Martina M.D.Chief Medical Officer | Jan 5 | Jan 6 | S | 3,205 | $170.61 | Sale −$546,805 | 101,053 | Yes | Form 4 |
| Flammer Martina M.D.Chief Medical Officer | Jan 5 | Jan 6 | S | 2,836 | $171.19 | Sale −$485,495 | 98,217 | Yes | Form 4 |
| Flammer Martina M.D.Chief Medical Officer | Jan 5 | Jan 6 | S | 286 | $171.92 | Sale −$49,169 | 97,931 | Yes | Form 4 |
| Flammer Martina M.D.Chief Medical Officer | Jan 5 | Jan 6 | S | 1,820 | $173.45 | Sale −$315,679 | 96,111 | Yes | Form 4 |
| Flammer Martina M.D.Chief Medical Officer | Jan 5 | Jan 6 | S | 655 | $174.28 | Sale −$114,153 | 95,456 | Yes | Form 4 |
| Flammer Martina M.D.Chief Medical Officer | Jan 5 | Jan 6 | S | 702 | $175.73 | Sale −$123,362 | 94,754 | Yes | Form 4 |
| Flammer Martina M.D.Chief Medical Officer | Jan 5 | Jan 6 | M · derivative | 4,358 | $19.74 | $86,027 | 8,715 | Yes | Form 4 |
| Flammer Martina M.D.Chief Medical Officer | Jan 5 | Jan 6 | M · derivative | 7,945 | $29.13 | $231,438 | 31,780 | Yes | Form 4 |
| Schaeffer Orlov S NicoleChief People Strategy Officer | Jan 2 | Jan 6 | A | 5,293 | not reported | not reported | 41,754 | Yes | Form 4 |
| Schaeffer Orlov S NicoleChief People Strategy Officer | Jan 2 | Jan 6 | M | 87,290 | $13.91 | $1,214,204 | 129,044 | Yes | Form 4 |
| Schaeffer Orlov S NicoleChief People Strategy Officer | Jan 2 | Jan 6 | S | 31,030 | $174.28 | Sale −$5,407,908 | 98,014 | Yes | Form 4 |
| Schaeffer Orlov S NicoleChief People Strategy Officer | Jan 2 | Jan 6 | S | 34,103 | $175.17 | Sale −$5,973,823 | 63,911 | Yes | Form 4 |
| Schaeffer Orlov S NicoleChief People Strategy Officer | Jan 2 | Jan 6 | S | 12,832 | $176.08 | Sale −$2,259,459 | 51,079 | Yes | Form 4 |
| Schaeffer Orlov S NicoleChief People Strategy Officer | Jan 2 | Jan 6 | S | 9,125 | $177.17 | Sale −$1,616,676 | 41,954 | Yes | Form 4 |
| Schaeffer Orlov S NicoleChief People Strategy Officer | Jan 2 | Jan 6 | S | 200 | $177.78 | Sale −$35,556 | 41,754 | Yes | Form 4 |
| Schaeffer Orlov S NicoleChief People Strategy Officer | Jan 2 | Jan 6 | A · derivative | 27,600 | $177.12 | $4,888,512 | 27,600 | Yes | Form 4 |
| Schaeffer Orlov S NicoleChief People Strategy Officer | Jan 2 | Jan 6 | M · derivative | 87,290 | $13.91 | $1,214,204 | not reported | Yes | Form 4 |
| Lewis WilliamChair and CEO | Jan 2 | Jan 6 | A | 21,172 | not reported | not reported | 325,083 | No | Form 4 |
| Lewis WilliamChair and CEO | Jan 2 | Jan 6 | A · derivative | 110,400 | $177.12 | $19,554,048 | 110,400 | No | Form 4 |
| Bonstein SaraChief Financial Officer | Jan 2 | Jan 6 | A | 5,998 | not reported | not reported | 79,503 | No | Form 4 |
| Bonstein SaraChief Financial Officer | Jan 2 | Jan 6 | A | 5,645 | not reported | not reported | 85,148 | No | Form 4 |
| Bonstein SaraChief Financial Officer | Jan 2 | Jan 6 | A · derivative | 31,280 | $177.12 | $5,540,314 | 31,280 | No | Form 4 |
| Adsett RogerChief Operating Officer | Jan 2 | Jan 6 | A | 5,998 | not reported | not reported | 111,891 | No | Form 4 |
| Adsett RogerChief Operating Officer | Jan 2 | Jan 6 | A · derivative | 31,280 | $177.12 | $5,540,314 | 31,280 | No | Form 4 |
| Flammer Martina M.D.Chief Medical Officer | Jan 2 | Jan 6 | A | 5,998 | not reported | not reported | 89,109 | Yes | Form 4 |
| Flammer Martina M.D.Chief Medical Officer | Jan 2 | Jan 6 | A | 5,645 | not reported | not reported | 94,754 | Yes | Form 4 |
| Flammer Martina M.D.Chief Medical Officer | Jan 2 | Jan 6 | A · derivative | 31,280 | $177.12 | $5,540,314 | 31,280 | Yes | Form 4 |
| Smith Michael AlexanderChief Legal Officer | Jan 2 | Jan 6 | A | 5,293 | not reported | not reported | 60,195 | No | Form 4 |
| Smith Michael AlexanderChief Legal Officer | Jan 2 | Jan 6 | A · derivative | 27,600 | $177.12 | $4,888,512 | 27,600 | No | Form 4 |
| Lewis WilliamChair and CEO | Dec 18, 2025 | Dec 19, 2025 | M | 4,440 | $17.16 | $76,190 | 308,351 | Yes | Form 4 |
| Lewis WilliamChair and CEO | Dec 18, 2025 | Dec 19, 2025 | M | 6,259 | $30.46 | $190,649 | 314,610 | Yes | Form 4 |
| Lewis WilliamChair and CEO | Dec 18, 2025 | Dec 19, 2025 | S | 350 | $162.26 | Sale −$56,791 | 314,260 | Yes | Form 4 |
| Lewis WilliamChair and CEO | Dec 18, 2025 | Dec 19, 2025 | S | 1,465 | $163.19 | Sale −$239,073 | 312,795 | Yes | Form 4 |
| Lewis WilliamChair and CEO | Dec 18, 2025 | Dec 19, 2025 | S | 447 | $164.24 | Sale −$73,415 | 312,348 | Yes | Form 4 |
| Lewis WilliamChair and CEO | Dec 18, 2025 | Dec 19, 2025 | S | 697 | $165.21 | Sale −$115,151 | 311,651 | Yes | Form 4 |
| Lewis WilliamChair and CEO | Dec 18, 2025 | Dec 19, 2025 | S | 1,783 | $166.60 | Sale −$297,048 | 309,868 | Yes | Form 4 |
| Lewis WilliamChair and CEO | Dec 18, 2025 | Dec 19, 2025 | S | 1,431 | $167.29 | Sale −$239,392 | 308,437 | Yes | Form 4 |
| Lewis WilliamChair and CEO | Dec 18, 2025 | Dec 19, 2025 | S | 2,175 | $168.54 | Sale −$366,575 | 306,262 | Yes | Form 4 |
| Lewis WilliamChair and CEO | Dec 18, 2025 | Dec 19, 2025 | S | 1,938 | $169.58 | Sale −$328,646 | 304,324 | Yes | Form 4 |
| Lewis WilliamChair and CEO | Dec 18, 2025 | Dec 19, 2025 | S | 362 | $170.26 | Sale −$61,634 | 303,962 | Yes | Form 4 |
| Lewis WilliamChair and CEO | Dec 18, 2025 | Dec 19, 2025 | S | 51 | $171.20 | Sale −$8,731 | 303,911 | Yes | Form 4 |
| Lewis WilliamChair and CEO | Dec 18, 2025 | Dec 19, 2025 | M · derivative | 4,440 | $17.16 | $76,190 | 62,160 | Yes | Form 4 |
| Lewis WilliamChair and CEO | Dec 18, 2025 | Dec 19, 2025 | M · derivative | 6,259 | $30.46 | $190,649 | 87,627 | Yes | Form 4 |
| Sharoky Melvin Md | Dec 5, 2025 | Dec 9, 2025 | S | 20,000 | $205.01 | Sale −$4,100,200 | 243,948 | No | Form 4 |
| Lewis WilliamChair and CEO | Dec 4, 2025 | Dec 5, 2025 | M | 6,259 | $30.46 | $190,649 | 310,170 | Yes | Form 4 |
| Lewis WilliamChair and CEO | Dec 4, 2025 | Dec 5, 2025 | M | 4,440 | $17.16 | $76,190 | 314,610 | Yes | Form 4 |
| Lewis WilliamChair and CEO | Dec 4, 2025 | Dec 5, 2025 | S | 4,516 | $204.62 | Sale −$924,064 | 310,094 | Yes | Form 4 |
| Lewis WilliamChair and CEO | Dec 4, 2025 | Dec 5, 2025 | S | 2,222 | $205.66 | Sale −$456,977 | 307,872 | Yes | Form 4 |
| Lewis WilliamChair and CEO | Dec 4, 2025 | Dec 5, 2025 | S | 2,921 | $206.49 | Sale −$603,157 | 304,951 | Yes | Form 4 |
| Lewis WilliamChair and CEO | Dec 4, 2025 | Dec 5, 2025 | S | 1,040 | $207.42 | Sale −$215,717 | 303,911 | Yes | Form 4 |
| Lewis WilliamChair and CEO | Dec 4, 2025 | Dec 5, 2025 | M · derivative | 6,259 | $30.46 | $190,649 | 93,886 | Yes | Form 4 |
| Lewis WilliamChair and CEO | Dec 4, 2025 | Dec 5, 2025 | M · derivative | 4,440 | $17.16 | $76,190 | 66,600 | Yes | Form 4 |
| Flammer Martina M.D.Chief Medical Officer | Dec 1, 2025 | Dec 3, 2025 | M | 8,895 | $25.83 | $229,758 | 92,006 | Yes | Form 4 |
| Flammer Martina M.D.Chief Medical Officer | Dec 1, 2025 | Dec 3, 2025 | S | 1,450 | $205.98 | Sale −$298,671 | 90,556 | Yes | Form 4 |
| Flammer Martina M.D.Chief Medical Officer | Dec 1, 2025 | Dec 3, 2025 | S | 5,886 | $207.03 | Sale −$1,218,579 | 84,670 | Yes | Form 4 |
| Flammer Martina M.D.Chief Medical Officer | Dec 1, 2025 | Dec 3, 2025 | S | 1,559 | $207.73 | Sale −$323,851 | 83,111 | Yes | Form 4 |
| Flammer Martina M.D.Chief Medical Officer | Dec 1, 2025 | Dec 3, 2025 | M · derivative | 8,895 | $25.83 | $229,758 | 44,475 | Yes | Form 4 |
| Anderson Elizabeth M | Nov 24, 2025 | Nov 26, 2025 | S | 5,000 | $204.58 | Sale −$1,022,900 | 58,729 | No | Form 4 |
| Lee Leo | Nov 17, 2025 | Nov 18, 2025 | S | 3,212 | $193.51 | Sale −$621,554 | 126,465 | No | Form 4 |
| Lee Leo | Nov 17, 2025 | Nov 18, 2025 | S | 17,594 | $194.49 | Sale −$3,421,857 | 108,871 | No | Form 4 |
| Lee Leo | Nov 17, 2025 | Nov 18, 2025 | S | 14,944 | $195.39 | Sale −$2,919,908 | 93,927 | No | Form 4 |
| Lee Leo | Nov 17, 2025 | Nov 18, 2025 | S | 24,076 | $196.61 | Sale −$4,733,582 | 69,851 | No | Form 4 |
| Lee Leo | Nov 17, 2025 | Nov 18, 2025 | S | 15,174 | $197.40 | Sale −$2,995,348 | 54,677 | No | Form 4 |
| Anderson Elizabeth M | Nov 14, 2025 | Nov 18, 2025 | S | 10,000 | $195.87 | Sale −$1,958,700 | 63,729 | No | Form 4 |
| Schaeffer Orlov S NicoleChief People Strategy Officer | Nov 12, 2025 | Nov 14, 2025 | M | 30,000 | $26.46 | $793,800 | 66,461 | No | Form 4 |
| Schaeffer Orlov S NicoleChief People Strategy Officer | Nov 12, 2025 | Nov 14, 2025 | S | 4,078 | $192.45 | Sale −$784,811 | 62,383 | No | Form 4 |
| Schaeffer Orlov S NicoleChief People Strategy Officer | Nov 12, 2025 | Nov 14, 2025 | S | 6,575 | $193.64 | Sale −$1,273,183 | 55,808 | No | Form 4 |
| Schaeffer Orlov S NicoleChief People Strategy Officer | Nov 12, 2025 | Nov 14, 2025 | S | 19,183 | $194.44 | Sale −$3,729,943 | 36,625 | No | Form 4 |
| Schaeffer Orlov S NicoleChief People Strategy Officer | Nov 12, 2025 | Nov 14, 2025 | S | 164 | $195.88 | Sale −$32,124 | 36,461 | No | Form 4 |
| Schaeffer Orlov S NicoleChief People Strategy Officer | Nov 12, 2025 | Nov 14, 2025 | M · derivative | 30,000 | $26.46 | $793,800 | 15,760 | No | Form 4 |
| Flammer Martina M.D.Chief Medical Officer | Nov 11, 2025 | Nov 13, 2025 | M | 12,949 | $17.07 | $221,039 | 96,060 | Yes | Form 4 |
| Flammer Martina M.D.Chief Medical Officer | Nov 11, 2025 | Nov 13, 2025 | M | 18,277 | $18.95 | $346,349 | 114,337 | Yes | Form 4 |
| Flammer Martina M.D.Chief Medical Officer | Nov 11, 2025 | Nov 13, 2025 | S | 5,467 | $188.38 | Sale −$1,029,873 | 108,870 | Yes | Form 4 |
| Flammer Martina M.D.Chief Medical Officer | Nov 11, 2025 | Nov 13, 2025 | S | 12,224 | $189.36 | Sale −$2,314,737 | 96,646 | Yes | Form 4 |
| Flammer Martina M.D.Chief Medical Officer | Nov 11, 2025 | Nov 13, 2025 | S | 10,622 | $190.33 | Sale −$2,021,685 | 86,024 | Yes | Form 4 |
| Flammer Martina M.D.Chief Medical Officer | Nov 11, 2025 | Nov 13, 2025 | S | 2,913 | $191.04 | Sale −$556,500 | 83,111 | Yes | Form 4 |
| Flammer Martina M.D.Chief Medical Officer | Nov 11, 2025 | Nov 13, 2025 | M · derivative | 12,949 | $17.07 | $221,039 | 12,949 | Yes | Form 4 |
| Flammer Martina M.D.Chief Medical Officer | Nov 11, 2025 | Nov 13, 2025 | M · derivative | 18,277 | $18.95 | $346,349 | 54,833 | Yes | Form 4 |
| Brennan David R | Nov 6, 2025 | Nov 10, 2025 | G | 60,000 | $0.00 | $0 | 66,933 | No | Form 4 |
| Brennan David R | Nov 6, 2025 | Nov 10, 2025 | G | 60,000 | $0.00 | $0 | 60,000 | No | Form 4 |
| Smith Michael AlexanderChief Legal Officer | Nov 3, 2025 | Nov 5, 2025 | M | 27,130 | $23.75 | $644,338 | 82,032 | Yes | Form 4 |
| Smith Michael AlexanderChief Legal Officer | Nov 3, 2025 | Nov 5, 2025 | S | 1,342 | $181.01 | Sale −$242,915 | 80,690 | Yes | Form 4 |
| Smith Michael AlexanderChief Legal Officer | Nov 3, 2025 | Nov 5, 2025 | S | 7,619 | $181.88 | Sale −$1,385,744 | 73,071 | Yes | Form 4 |
| Smith Michael AlexanderChief Legal Officer | Nov 3, 2025 | Nov 5, 2025 | S | 4,286 | $182.60 | Sale −$782,624 | 68,785 | Yes | Form 4 |
| Smith Michael AlexanderChief Legal Officer | Nov 3, 2025 | Nov 5, 2025 | S | 4,032 | $183.92 | Sale −$741,565 | 64,753 | Yes | Form 4 |
| Smith Michael AlexanderChief Legal Officer | Nov 3, 2025 | Nov 5, 2025 | S | 3,243 | $184.91 | Sale −$599,663 | 61,510 | Yes | Form 4 |
| Smith Michael AlexanderChief Legal Officer | Nov 3, 2025 | Nov 5, 2025 | S | 3,636 | $185.93 | Sale −$676,041 | 57,874 | Yes | Form 4 |
| Smith Michael AlexanderChief Legal Officer | Nov 3, 2025 | Nov 5, 2025 | S | 1,572 | $187.15 | Sale −$294,200 | 56,302 | Yes | Form 4 |
| Smith Michael AlexanderChief Legal Officer | Nov 3, 2025 | Nov 5, 2025 | S | 1,400 | $187.97 | Sale −$263,158 | 54,902 | Yes | Form 4 |
| Smith Michael AlexanderChief Legal Officer | Nov 3, 2025 | Nov 5, 2025 | M · derivative | 27,130 | $23.75 | $644,338 | not reported | Yes | Form 4 |
| Sharoky Melvin Md | Sep 12, 2025 | Sep 15, 2025 | S | 10,000 | $145.39 | Sale −$1,453,900 | 262,675 | No | Form 4 |
| Schaeffer Orlov S NicoleChief People Strategy Officer | Sep 12, 2025 | Sep 15, 2025 | M | 56,520 | $23.75 | $1,342,350 | 112,981 | Yes | Form 4 |
| Schaeffer Orlov S NicoleChief People Strategy Officer | Sep 12, 2025 | Sep 15, 2025 | S | 32,091 | $144.60 | Sale −$4,640,359 | 80,890 | Yes | Form 4 |
| Schaeffer Orlov S NicoleChief People Strategy Officer | Sep 12, 2025 | Sep 15, 2025 | S | 30,967 | $145.67 | Sale −$4,510,963 | 49,923 | Yes | Form 4 |
| Schaeffer Orlov S NicoleChief People Strategy Officer | Sep 12, 2025 | Sep 15, 2025 | S | 7,304 | $146.57 | Sale −$1,070,547 | 42,619 | Yes | Form 4 |
| Schaeffer Orlov S NicoleChief People Strategy Officer | Sep 12, 2025 | Sep 15, 2025 | S | 6,158 | $147.46 | Sale −$908,059 | 36,461 | Yes | Form 4 |
| Schaeffer Orlov S NicoleChief People Strategy Officer | Sep 12, 2025 | Sep 15, 2025 | M · derivative | 56,520 | $23.75 | $1,342,350 | not reported | Yes | Form 4 |
| Sharoky Melvin Md | Sep 11, 2025 | Sep 15, 2025 | G | 2,000 | $0.00 | $0 | 272,516 | No | Form 4 |
| Sharoky Melvin Md | Sep 11, 2025 | Sep 15, 2025 | G | 159 | $0.00 | $0 | 741 | No | Form 4 |
| Sharoky Melvin Md | Sep 11, 2025 | Sep 15, 2025 | G | 159 | $0.00 | $0 | 272,675 | No | Form 4 |
| Schaeffer Orlov S NicoleChief People Strategy Officer | Sep 4, 2025 | Sep 5, 2025 | G | 23,303 | $0.00 | $0 | 56,461 | No | Form 4 |
| Flammer Martina M.D.Chief Medical Officer | Sep 2, 2025 | Sep 4, 2025 | M | 13,680 | $34.03 | $465,530 | 96,791 | Yes | Form 4 |
| Flammer Martina M.D.Chief Medical Officer | Sep 2, 2025 | Sep 4, 2025 | M | 17,160 | $26.46 | $454,054 | 113,951 | Yes | Form 4 |
| Flammer Martina M.D.Chief Medical Officer | Sep 2, 2025 | Sep 4, 2025 | M | 25,710 | $26.43 | $679,515 | 139,661 | Yes | Form 4 |
| Flammer Martina M.D.Chief Medical Officer | Sep 2, 2025 | Sep 4, 2025 | M | 38,846 | $17.07 | $663,101 | 178,507 | Yes | Form 4 |
| Flammer Martina M.D.Chief Medical Officer | Sep 2, 2025 | Sep 4, 2025 | M | 13,072 | $19.74 | $258,041 | 191,579 | Yes | Form 4 |
| Flammer Martina M.D.Chief Medical Officer | Sep 2, 2025 | Sep 4, 2025 | M | 36,555 | $18.95 | $692,717 | 228,134 | Yes | Form 4 |
| Flammer Martina M.D.Chief Medical Officer | Sep 2, 2025 | Sep 4, 2025 | M | 23,835 | $29.13 | $694,314 | 251,969 | Yes | Form 4 |
| Flammer Martina M.D.Chief Medical Officer | Sep 2, 2025 | Sep 4, 2025 | M | 17,790 | $25.83 | $459,516 | 269,759 | Yes | Form 4 |
| Flammer Martina M.D.Chief Medical Officer | Sep 2, 2025 | Sep 4, 2025 | S | 19,066 | $141.27 | Sale −$2,693,454 | 250,693 | Yes | Form 4 |
| Flammer Martina M.D.Chief Medical Officer | Sep 2, 2025 | Sep 4, 2025 | S | 5,877 | $142.03 | Sale −$834,710 | 244,816 | Yes | Form 4 |
| Flammer Martina M.D.Chief Medical Officer | Sep 2, 2025 | Sep 4, 2025 | S | 35,245 | $143.16 | Sale −$5,045,674 | 209,571 | Yes | Form 4 |
| Flammer Martina M.D.Chief Medical Officer | Sep 2, 2025 | Sep 4, 2025 | S | 28,063 | $144.05 | Sale −$4,042,475 | 181,508 | Yes | Form 4 |
| Flammer Martina M.D.Chief Medical Officer | Sep 2, 2025 | Sep 4, 2025 | S | 63,782 | $145.33 | Sale −$9,269,438 | 117,726 | Yes | Form 4 |
| Flammer Martina M.D.Chief Medical Officer | Sep 2, 2025 | Sep 4, 2025 | S | 34,615 | $146.05 | Sale −$5,055,521 | 83,111 | Yes | Form 4 |
| Flammer Martina M.D.Chief Medical Officer | Sep 2, 2025 | Sep 4, 2025 | M · derivative | 13,680 | $34.03 | $465,530 | not reported | Yes | Form 4 |
| Flammer Martina M.D.Chief Medical Officer | Sep 2, 2025 | Sep 4, 2025 | M · derivative | 17,160 | $26.46 | $454,054 | not reported | Yes | Form 4 |
| Flammer Martina M.D.Chief Medical Officer | Sep 2, 2025 | Sep 4, 2025 | M · derivative | 25,710 | $26.43 | $679,515 | 8,570 | Yes | Form 4 |
| Flammer Martina M.D.Chief Medical Officer | Sep 2, 2025 | Sep 4, 2025 | M · derivative | 38,846 | $17.07 | $663,101 | 25,898 | Yes | Form 4 |
| Flammer Martina M.D.Chief Medical Officer | Sep 2, 2025 | Sep 4, 2025 | M · derivative | 13,072 | $19.74 | $258,041 | 13,073 | Yes | Form 4 |
| Flammer Martina M.D.Chief Medical Officer | Sep 2, 2025 | Sep 4, 2025 | M · derivative | 36,555 | $18.95 | $692,717 | 73,110 | Yes | Form 4 |
| Flammer Martina M.D.Chief Medical Officer | Sep 2, 2025 | Sep 4, 2025 | M · derivative | 23,835 | $29.13 | $694,314 | 39,725 | Yes | Form 4 |
| Flammer Martina M.D.Chief Medical Officer | Sep 2, 2025 | Sep 4, 2025 | M · derivative | 17,790 | $25.83 | $459,516 | 53,370 | Yes | Form 4 |
| Smith Michael AlexanderChief Legal Officer | Sep 2, 2025 | Sep 4, 2025 | M | 12,780 | $30.46 | $389,279 | 79,174 | Yes | Form 4 |
| Smith Michael AlexanderChief Legal Officer | Sep 2, 2025 | Sep 4, 2025 | S | 1,354 | $141.16 | Sale −$191,131 | 77,820 | Yes | Form 4 |
| Smith Michael AlexanderChief Legal Officer | Sep 2, 2025 | Sep 4, 2025 | S | 1,100 | $142.06 | Sale −$156,266 | 76,720 | Yes | Form 4 |
| Smith Michael AlexanderChief Legal Officer | Sep 2, 2025 | Sep 4, 2025 | S | 7,391 | $143.16 | Sale −$1,058,096 | 69,329 | Yes | Form 4 |
| Smith Michael AlexanderChief Legal Officer | Sep 2, 2025 | Sep 4, 2025 | S | 8,300 | $144.16 | Sale −$1,196,528 | 61,029 | Yes | Form 4 |
| Smith Michael AlexanderChief Legal Officer | Sep 2, 2025 | Sep 4, 2025 | S | 4,944 | $145.18 | Sale −$717,770 | 56,085 | Yes | Form 4 |
| Smith Michael AlexanderChief Legal Officer | Sep 2, 2025 | Sep 4, 2025 | S | 1,183 | $145.89 | Sale −$172,588 | 54,902 | Yes | Form 4 |
| Smith Michael AlexanderChief Legal Officer | Sep 2, 2025 | Sep 4, 2025 | M · derivative | 12,780 | $30.46 | $389,279 | not reported | Yes | Form 4 |
| Sharoky Melvin Md | Aug 20, 2025 | Aug 21, 2025 | S | 10,000 | $129.50 | Sale −$1,295,000 | 274,516 | No | Form 4 |
| Adsett RogerChief Operating Officer | Aug 19, 2025 | Aug 21, 2025 | S | 20,193 | $127.42 | Sale −$2,572,992 | 110,444 | No | Form 4 |
| Adsett RogerChief Operating Officer | Aug 19, 2025 | Aug 21, 2025 | S | 4,807 | $128.27 | Sale −$616,594 | 105,637 | No | Form 4 |
| Lewis WilliamChair and CEO | Aug 18, 2025 | Aug 20, 2025 | M | 6,865 | $10.85 | $74,485 | 240,789 | Yes | Form 4 |
| Lewis WilliamChair and CEO | Aug 18, 2025 | Aug 20, 2025 | S | 2,968 | $127.59 | Sale −$378,687 | 237,821 | Yes | Form 4 |
| Lewis WilliamChair and CEO | Aug 18, 2025 | Aug 20, 2025 | S | 2,481 | $128.76 | Sale −$319,454 | 235,340 | Yes | Form 4 |
| Lewis WilliamChair and CEO | Aug 18, 2025 | Aug 20, 2025 | S | 1,416 | $129.47 | Sale −$183,330 | 233,924 | Yes | Form 4 |
| Lewis WilliamChair and CEO | Aug 18, 2025 | Aug 20, 2025 | M · derivative | 6,865 | $10.85 | $74,485 | not reported | Yes | Form 4 |
| Schaeffer Orlov S NicoleChief People Strategy Officer | Aug 14, 2025 | Aug 18, 2025 | S | 3,554 | $126.57 | Sale −$449,830 | 86,210 | No | Form 4 |
| Schaeffer Orlov S NicoleChief People Strategy Officer | Aug 14, 2025 | Aug 18, 2025 | S | 5,746 | $127.71 | Sale −$733,822 | 80,464 | No | Form 4 |
| Schaeffer Orlov S NicoleChief People Strategy Officer | Aug 14, 2025 | Aug 18, 2025 | S | 700 | $128.16 | Sale −$89,712 | 79,764 | No | Form 4 |
| Sharoky Melvin Md | Aug 13, 2025 | Aug 14, 2025 | G | 6,100 | $0.00 | $0 | 284,516 | No | Form 4 |
| Sharoky Melvin Md | Aug 13, 2025 | Aug 14, 2025 | G | 15,000 | $0.00 | $0 | 900 | No | Form 4 |
| Sharoky Melvin Md | Aug 13, 2025 | Aug 14, 2025 | G | 5,000 | $0.00 | $0 | 6,847 | No | Form 4 |
| Sharoky Melvin Md | Aug 12, 2025 | Aug 14, 2025 | S | 10,000 | $121.58 | Sale −$1,215,800 | 290,616 | No | Form 4 |
| Lewis WilliamChair and CEO | Aug 4, 2025 | Aug 6, 2025 | M | 6,830 | $10.85 | $74,106 | 240,754 | Yes | Form 4 |
| Lewis WilliamChair and CEO | Aug 4, 2025 | Aug 6, 2025 | S | 1,693 | $108.80 | Sale −$184,198 | 239,061 | Yes | Form 4 |
| Lewis WilliamChair and CEO | Aug 4, 2025 | Aug 6, 2025 | S | 3,199 | $109.68 | Sale −$350,866 | 235,862 | Yes | Form 4 |
| Lewis WilliamChair and CEO | Aug 4, 2025 | Aug 6, 2025 | S | 1,938 | $110.91 | Sale −$214,944 | 233,924 | Yes | Form 4 |
| Lewis WilliamChair and CEO | Aug 4, 2025 | Aug 6, 2025 | M · derivative | 6,830 | $10.85 | $74,106 | 6,865 | Yes | Form 4 |
| Flammer Martina M.D.Chief Medical Officer | Aug 4, 2025 | Aug 6, 2025 | M | 8,715 | $19.74 | $172,034 | 91,826 | Yes | Form 4 |
| Flammer Martina M.D.Chief Medical Officer | Aug 4, 2025 | Aug 6, 2025 | S | 8,715 | $109.50 | Sale −$954,293 | 83,111 | Yes | Form 4 |
| Flammer Martina M.D.Chief Medical Officer | Aug 4, 2025 | Aug 6, 2025 | M · derivative | 8,715 | $19.74 | $172,034 | 26,145 | Yes | Form 4 |
| Bonstein SaraChief Financial Officer | Jul 21, 2025 | Jul 23, 2025 | M | 3,443 | $26.46 | $91,102 | 87,460 | Yes | Form 4 |
| Bonstein SaraChief Financial Officer | Jul 21, 2025 | Jul 23, 2025 | M | 11,455 | $28.88 | $330,820 | 98,915 | Yes | Form 4 |
| Bonstein SaraChief Financial Officer | Jul 21, 2025 | Jul 23, 2025 | M | 15,890 | $29.13 | $462,876 | 114,805 | Yes | Form 4 |
| Bonstein SaraChief Financial Officer | Jul 21, 2025 | Jul 23, 2025 | M | 17,100 | $34.03 | $581,913 | 131,905 | Yes | Form 4 |
| Bonstein SaraChief Financial Officer | Jul 21, 2025 | Jul 23, 2025 | S | 32,090 | $102.38 | Sale −$3,285,374 | 99,815 | Yes | Form 4 |
| Bonstein SaraChief Financial Officer | Jul 21, 2025 | Jul 23, 2025 | S | 26,310 | $103.03 | Sale −$2,710,719 | 73,505 | Yes | Form 4 |
| Bonstein SaraChief Financial Officer | Jul 21, 2025 | Jul 23, 2025 | M · derivative | 3,443 | $26.46 | $91,102 | 8,580 | Yes | Form 4 |
| Bonstein SaraChief Financial Officer | Jul 21, 2025 | Jul 23, 2025 | M · derivative | 11,455 | $28.88 | $330,820 | not reported | Yes | Form 4 |
| Bonstein SaraChief Financial Officer | Jul 21, 2025 | Jul 23, 2025 | M · derivative | 15,890 | $29.13 | $462,876 | 47,670 | Yes | Form 4 |
| Bonstein SaraChief Financial Officer | Jul 21, 2025 | Jul 23, 2025 | M · derivative | 17,100 | $34.03 | $581,913 | not reported | Yes | Form 4 |
| Smith Michael AlexanderChief Legal Officer | Jul 15, 2025 | Jul 15, 2025 | S | 933 | $102.51 | Sale −$95,642 | 66,394 | Yes | Form 4 |
| Lewis WilliamChair and CEO | Jul 15, 2025 | Jul 15, 2025 | M | 6,830 | $10.85 | $74,106 | 240,754 | Yes | Form 4 |
| Lewis WilliamChair and CEO | Jul 15, 2025 | Jul 15, 2025 | S | 2,168 | $101.71 | Sale −$220,507 | 238,586 | Yes | Form 4 |
| Lewis WilliamChair and CEO | Jul 15, 2025 | Jul 15, 2025 | S | 4,492 | $102.66 | Sale −$461,149 | 234,094 | Yes | Form 4 |
| Lewis WilliamChair and CEO | Jul 15, 2025 | Jul 15, 2025 | S | 170 | $103.32 | Sale −$17,564 | 233,924 | Yes | Form 4 |
| Lewis WilliamChair and CEO | Jul 15, 2025 | Jul 15, 2025 | M · derivative | 6,830 | $10.85 | $74,106 | 13,695 | Yes | Form 4 |
| Smith Michael AlexanderChief Legal Officer | Jul 11, 2025 | Jul 15, 2025 | S | 748 | $96.41 | Sale −$72,115 | 67,327 | Yes | Form 4 |
| Bonstein SaraChief Financial Officer | Jul 7, 2025 | Jul 9, 2025 | M | 6,244 | $19.74 | $123,257 | 100,137 | Yes | Form 4 |
| Bonstein SaraChief Financial Officer | Jul 7, 2025 | Jul 9, 2025 | M | 4,362 | $24.70 | $107,741 | 104,499 | Yes | Form 4 |
| Bonstein SaraChief Financial Officer | Jul 7, 2025 | Jul 9, 2025 | M | 23,565 | $26.43 | $622,823 | 128,064 | Yes | Form 4 |
| Bonstein SaraChief Financial Officer | Jul 7, 2025 | Jul 9, 2025 | M | 13,717 | $26.46 | $362,952 | 141,781 | Yes | Form 4 |
| Bonstein SaraChief Financial Officer | Jul 7, 2025 | Jul 9, 2025 | S | 35,583 | $95.66 | Sale −$3,403,870 | 106,198 | Yes | Form 4 |
| Bonstein SaraChief Financial Officer | Jul 7, 2025 | Jul 9, 2025 | S | 22,181 | $96.19 | Sale −$2,133,590 | 84,017 | Yes | Form 4 |
| Bonstein SaraChief Financial Officer | Jul 7, 2025 | Jul 9, 2025 | M · derivative | 6,244 | $19.74 | $123,257 | 18,880 | Yes | Form 4 |
| Bonstein SaraChief Financial Officer | Jul 7, 2025 | Jul 9, 2025 | M · derivative | 4,362 | $24.70 | $107,741 | not reported | Yes | Form 4 |
| Bonstein SaraChief Financial Officer | Jul 7, 2025 | Jul 9, 2025 | M · derivative | 23,565 | $26.43 | $622,823 | 15,710 | Yes | Form 4 |
| Bonstein SaraChief Financial Officer | Jul 7, 2025 | Jul 9, 2025 | M · derivative | 13,717 | $26.46 | $362,952 | 12,023 | Yes | Form 4 |
| Lewis WilliamChair and CEO | Jul 1, 2025 | Jul 2, 2025 | M | 6,830 | $10.85 | $74,106 | 240,754 | Yes | Form 4 |
| Lewis WilliamChair and CEO | Jul 1, 2025 | Jul 2, 2025 | S | 3,666 | $97.73 | Sale −$358,278 | 237,088 | Yes | Form 4 |
| Lewis WilliamChair and CEO | Jul 1, 2025 | Jul 2, 2025 | S | 2,349 | $98.83 | Sale −$232,152 | 234,739 | Yes | Form 4 |
| Lewis WilliamChair and CEO | Jul 1, 2025 | Jul 2, 2025 | S | 815 | $99.61 | Sale −$81,182 | 233,924 | Yes | Form 4 |
| Lewis WilliamChair and CEO | Jul 1, 2025 | Jul 2, 2025 | M · derivative | 6,830 | $10.85 | $74,106 | 20,525 | Yes | Form 4 |
| Bonstein SaraChief Financial Officer | Jun 23, 2025 | Jun 25, 2025 | M | 35,253 | $18.95 | $668,044 | 138,665 | Yes | Form 4 |
| Bonstein SaraChief Financial Officer | Jun 23, 2025 | Jun 25, 2025 | M | 12,636 | $19.74 | $249,435 | 151,301 | Yes | Form 4 |
| Bonstein SaraChief Financial Officer | Jun 23, 2025 | Jun 25, 2025 | S | 49,104 | $101.71 | Sale −$4,994,368 | 102,197 | Yes | Form 4 |
| Bonstein SaraChief Financial Officer | Jun 23, 2025 | Jun 25, 2025 | S | 8,661 | $102.15 | Sale −$884,721 | 93,536 | Yes | Form 4 |
| Bonstein SaraChief Financial Officer | Jun 23, 2025 | Jun 25, 2025 | M · derivative | 35,253 | $18.95 | $668,044 | 99,007 | Yes | Form 4 |
| Bonstein SaraChief Financial Officer | Jun 23, 2025 | Jun 25, 2025 | M · derivative | 12,636 | $19.74 | $249,435 | 25,124 | Yes | Form 4 |
| Adsett RogerChief Operating Officer | Jun 16, 2025 | Jun 18, 2025 | S | 6,500 | $98.50 | Sale −$640,250 | 134,823 | Yes | Form 4 |
| Adsett RogerChief Operating Officer | Jun 16, 2025 | Jun 18, 2025 | S | 4,186 | $99.32 | Sale −$415,754 | 130,637 | Yes | Form 4 |
| Lewis WilliamChair and CEO | Jun 16, 2025 | Jun 18, 2025 | S | 442 | $98.51 | Sale −$43,541 | 308,316 | Yes | Form 4 |
| Lewis WilliamChair and CEO | Jun 16, 2025 | Jun 18, 2025 | S | 1,558 | $99.65 | Sale −$155,255 | 306,758 | Yes | Form 4 |
| Lewis WilliamChair and CEO | Jun 16, 2025 | Jun 18, 2025 | S | 2,300 | $100.70 | Sale −$231,610 | 304,458 | Yes | Form 4 |
| Lewis WilliamChair and CEO | Jun 16, 2025 | Jun 18, 2025 | S | 904 | $101.39 | Sale −$91,657 | 303,554 | Yes | Form 4 |
| Lewis WilliamChair and CEO | Jun 16, 2025 | Jun 18, 2025 | M | 129,805 | $10.85 | $1,408,384 | 363,729 | Yes | Form 4 |
| Lewis WilliamChair and CEO | Jun 16, 2025 | Jun 18, 2025 | S | 7,000 | $98.50 | Sale −$689,500 | 356,729 | Yes | Form 4 |
| Lewis WilliamChair and CEO | Jun 16, 2025 | Jun 18, 2025 | S | 32,490 | $99.51 | Sale −$3,233,080 | 324,239 | Yes | Form 4 |
| Lewis WilliamChair and CEO | Jun 16, 2025 | Jun 18, 2025 | S | 48,531 | $100.54 | Sale −$4,879,307 | 275,708 | Yes | Form 4 |
| Lewis WilliamChair and CEO | Jun 16, 2025 | Jun 18, 2025 | S | 41,784 | $101.23 | Sale −$4,229,794 | 233,924 | Yes | Form 4 |
| Lewis WilliamChair and CEO | Jun 16, 2025 | Jun 18, 2025 | M · derivative | 129,805 | $10.85 | $1,408,384 | 27,355 | Yes | Form 4 |
| Schaeffer Orlov S NicoleChief People Strategy Officer | Jun 11, 2025 | Jun 12, 2025 | M | 70,000 | $13.91 | $973,700 | 188,579 | Yes | Form 4 |
| Schaeffer Orlov S NicoleChief People Strategy Officer | Jun 11, 2025 | Jun 12, 2025 | S | 35,072 | $91.68 | Sale −$3,215,401 | 153,507 | Yes | Form 4 |
| Schaeffer Orlov S NicoleChief People Strategy Officer | Jun 11, 2025 | Jun 12, 2025 | S | 18,319 | $92.73 | Sale −$1,698,721 | 135,188 | Yes | Form 4 |
| Schaeffer Orlov S NicoleChief People Strategy Officer | Jun 11, 2025 | Jun 12, 2025 | S | 10,781 | $93.48 | Sale −$1,007,808 | 124,407 | Yes | Form 4 |
| Schaeffer Orlov S NicoleChief People Strategy Officer | Jun 11, 2025 | Jun 12, 2025 | S | 34,500 | $95.49 | Sale −$3,294,405 | 89,907 | Yes | Form 4 |
| Schaeffer Orlov S NicoleChief People Strategy Officer | Jun 11, 2025 | Jun 12, 2025 | S | 500 | $96.02 | Sale −$48,010 | 89,407 | Yes | Form 4 |
| Schaeffer Orlov S NicoleChief People Strategy Officer | Jun 11, 2025 | Jun 12, 2025 | M · derivative | 70,000 | $13.91 | $973,700 | 87,290 | Yes | Form 4 |
| Flammer Martina M.D.Chief Medical Officer | Jun 11, 2025 | Jun 12, 2025 | M | 19,423 | $17.07 | $331,551 | 102,534 | Yes | Form 4 |
| Flammer Martina M.D.Chief Medical Officer | Jun 11, 2025 | Jun 12, 2025 | S | 19,423 | $94.50 | Sale −$1,835,474 | 83,111 | Yes | Form 4 |
| Flammer Martina M.D.Chief Medical Officer | Jun 11, 2025 | Jun 12, 2025 | M · derivative | 19,423 | $17.07 | $331,551 | 64,744 | Yes | Form 4 |
| Bonstein SaraChief Financial Officer | Jun 10, 2025 | Jun 12, 2025 | M | 24,150 | $18.95 | $457,643 | 137,438 | Yes | Form 4 |
| Bonstein SaraChief Financial Officer | Jun 10, 2025 | Jun 12, 2025 | M | 23,740 | $17.07 | $405,242 | 161,178 | Yes | Form 4 |
| Bonstein SaraChief Financial Officer | Jun 10, 2025 | Jun 12, 2025 | S | 7,277 | $87.12 | Sale −$633,972 | 153,901 | Yes | Form 4 |
| Bonstein SaraChief Financial Officer | Jun 10, 2025 | Jun 12, 2025 | S | 7,310 | $88.29 | Sale −$645,400 | 146,591 | Yes | Form 4 |
| Bonstein SaraChief Financial Officer | Jun 10, 2025 | Jun 12, 2025 | S | 20,926 | $88.99 | Sale −$1,862,205 | 125,665 | Yes | Form 4 |
| Bonstein SaraChief Financial Officer | Jun 10, 2025 | Jun 12, 2025 | S | 15,825 | $89.85 | Sale −$1,421,876 | 109,840 | Yes | Form 4 |
| Bonstein SaraChief Financial Officer | Jun 10, 2025 | Jun 12, 2025 | S | 6,328 | $90.93 | Sale −$575,405 | 103,512 | Yes | Form 4 |
| Bonstein SaraChief Financial Officer | Jun 10, 2025 | Jun 12, 2025 | S | 100 | $91.66 | Sale −$9,166 | 103,412 | Yes | Form 4 |
| Bonstein SaraChief Financial Officer | Jun 10, 2025 | Jun 12, 2025 | M · derivative | 24,150 | $18.95 | $457,643 | 134,260 | Yes | Form 4 |
| Bonstein SaraChief Financial Officer | Jun 10, 2025 | Jun 12, 2025 | M · derivative | 23,740 | $17.07 | $405,242 | 35,610 | Yes | Form 4 |
| Schaeffer Orlov S NicoleChief People Strategy Officer | Jun 10, 2025 | Jun 12, 2025 | M | 38,300 | $17.16 | $657,228 | 156,879 | Yes | Form 4 |
| Schaeffer Orlov S NicoleChief People Strategy Officer | Jun 10, 2025 | Jun 12, 2025 | S | 38,300 | $88.64 | Sale −$3,394,912 | 118,579 | Yes | Form 4 |
| Schaeffer Orlov S NicoleChief People Strategy Officer | Jun 10, 2025 | Jun 12, 2025 | M · derivative | 38,300 | $17.16 | $657,228 | not reported | Yes | Form 4 |
| Flammer Martina M.D.Chief Medical Officer | Jun 10, 2025 | Jun 12, 2025 | M | 25,740 | $26.46 | $681,080 | 108,851 | Yes | Form 4 |
| Flammer Martina M.D.Chief Medical Officer | Jun 10, 2025 | Jun 12, 2025 | S | 25,740 | $88.64 | Sale −$2,281,594 | 83,111 | Yes | Form 4 |
| Flammer Martina M.D.Chief Medical Officer | Jun 10, 2025 | Jun 12, 2025 | M · derivative | 25,740 | $26.46 | $681,080 | 17,160 | Yes | Form 4 |
| Smith Michael AlexanderChief Legal Officer | Jun 5, 2025 | Jun 6, 2025 | S | 1,879 | $73.50 | Sale −$138,107 | 67,718 | Yes | Form 4 |
| Mcgirr David W J | Jun 4, 2025 | Jun 4, 2025 | S | 3,000 | $73.27 | Sale −$219,810 | 97,723 | Yes | Form 4 |
| Lewis WilliamChair and CEO | Jun 3, 2025 | Jun 4, 2025 | S | 5,472 | $71.50 | Sale −$391,248 | 308,758 | Yes | Form 4 |
| Mcgirr David W J | Jun 3, 2025 | Jun 4, 2025 | S | 3,250 | $71.30 | Sale −$231,725 | 100,723 | Yes | Form 4 |
| Schaeffer Orlov S NicoleChief People Strategy Officer | Jun 3, 2025 | Jun 4, 2025 | S | 1,642 | $71.50 | Sale −$117,403 | 118,579 | No | Form 4 |
| Bonstein SaraChief Financial Officer | Jun 3, 2025 | Jun 4, 2025 | S | 1,579 | $71.50 | Sale −$112,899 | 113,288 | No | Form 4 |
| Adsett RogerChief Operating Officer | Jun 3, 2025 | Jun 4, 2025 | S | 1,860 | $71.50 | Sale −$132,990 | 141,323 | No | Form 4 |
| Flammer Martina M.D.Chief Medical Officer | Jun 3, 2025 | Jun 4, 2025 | S | 1,686 | $71.50 | Sale −$120,549 | 83,111 | No | Form 4 |
| Smith Michael AlexanderChief Legal Officer | Jun 3, 2025 | Jun 4, 2025 | S | 1,448 | $71.50 | Sale −$103,532 | 69,597 | No | Form 4 |
| Lewis WilliamChair and CEO | Jun 2, 2025 | Jun 4, 2025 | M | 6,830 | $10.85 | $74,106 | 240,754 | Yes | Form 4 |
| Lewis WilliamChair and CEO | Jun 2, 2025 | Jun 4, 2025 | S | 1,000 | $70.23 | Sale −$70,230 | 239,754 | Yes | Form 4 |
| Lewis WilliamChair and CEO | Jun 2, 2025 | Jun 4, 2025 | S | 4,400 | $71.35 | Sale −$313,940 | 235,354 | Yes | Form 4 |
| Lewis WilliamChair and CEO | Jun 2, 2025 | Jun 4, 2025 | S | 1,430 | $71.94 | Sale −$102,874 | 233,924 | Yes | Form 4 |
| Lewis WilliamChair and CEO | Jun 2, 2025 | Jun 4, 2025 | M · derivative | 6,830 | $10.85 | $74,106 | 157,160 | Yes | Form 4 |
| Smith Michael AlexanderChief Legal Officer | May 30, 2025 | Jun 3, 2025 | S | 6,327 | $68.56 | Sale −$433,779 | 91,045 | Yes | Form 4 |
| Smith Michael AlexanderChief Legal Officer | May 30, 2025 | Jun 3, 2025 | S | 20,000 | $70.00 | Sale −$1,400,000 | 71,045 | Yes | Form 4 |
| Sharoky Melvin Md | May 27, 2025 | May 29, 2025 | G | 200 | $0.00 | $0 | 300,616 | No | Form 4 |
| Desjardins Clarissa | May 21, 2025 | May 22, 2025 | P | 1,130 | $66.35 | Purchase +$74,976 | 3,025 | No | Form 4 |
| Lewis WilliamChair and CEO | May 20, 2025 | May 22, 2025 | S | 9,489 | $66.87 | Sale −$634,529 | 325,798 | Yes | Form 4 |
| Lewis WilliamChair and CEO | May 20, 2025 | May 22, 2025 | S | 4,480 | $67.96 | Sale −$304,461 | 321,318 | Yes | Form 4 |
| Lewis WilliamChair and CEO | May 20, 2025 | May 22, 2025 | S | 7,088 | $68.49 | Sale −$485,457 | 314,230 | Yes | Form 4 |
| Lewis WilliamChair and CEO | May 20, 2025 | May 22, 2025 | M | 6,830 | $10.85 | $74,106 | 240,754 | Yes | Form 4 |
| Lewis WilliamChair and CEO | May 20, 2025 | May 22, 2025 | S | 2,863 | $66.90 | Sale −$191,535 | 237,891 | Yes | Form 4 |
| Lewis WilliamChair and CEO | May 20, 2025 | May 22, 2025 | S | 2,251 | $68.13 | Sale −$153,361 | 235,640 | Yes | Form 4 |
| Lewis WilliamChair and CEO | May 20, 2025 | May 22, 2025 | S | 1,716 | $68.54 | Sale −$117,615 | 233,924 | Yes | Form 4 |
| Lewis WilliamChair and CEO | May 20, 2025 | May 22, 2025 | M · derivative | 6,830 | $10.85 | $74,106 | 163,990 | Yes | Form 4 |
| Desjardins Clarissa | May 20, 2025 | May 22, 2025 | P | 1,895 | $66.87 | Purchase +$126,719 | 1,895 | No | Form 4 |
| Sharoky Melvin Md | May 20, 2025 | May 22, 2025 | G | 400 | $0.00 | $0 | 300,816 | No | Form 4 |
| Sharoky Melvin Md | May 20, 2025 | May 22, 2025 | G | 100 | $0.00 | $0 | 100 | No | Form 4 |
| Sharoky Melvin Md | May 20, 2025 | May 22, 2025 | G | 100 | $0.00 | $0 | 100 | No | Form 4 |
| Sharoky Melvin Md | May 20, 2025 | May 22, 2025 | G | 100 | $0.00 | $0 | 100 | No | Form 4 |
| Sharoky Melvin Md | May 20, 2025 | May 22, 2025 | G | 100 | $0.00 | $0 | 100 | No | Form 4 |
| Flammer Martina M.D.Chief Medical Officer | May 16, 2025 | May 19, 2025 | S | 1,799 | $67.53 | Sale −$121,486 | 84,797 | Yes | Form 4 |
| Lee Leo | May 15, 2025 | May 19, 2025 | A | 5,058 | not reported | not reported | 129,677 | No | Form 4 |
| Mcgirr David W J | May 15, 2025 | May 19, 2025 | A | 5,058 | not reported | not reported | 103,973 | No | Form 4 |
| Anderson Elizabeth M | May 15, 2025 | May 19, 2025 | A | 5,058 | not reported | not reported | 73,729 | No | Form 4 |
| Sharoky Melvin Md | May 15, 2025 | May 19, 2025 | A | 5,058 | not reported | not reported | 301,216 | No | Form 4 |
| Desjardins Clarissa | May 15, 2025 | May 19, 2025 | A | 5,058 | not reported | not reported | 67,007 | No | Form 4 |
| Schafer Carol | May 15, 2025 | May 19, 2025 | A | 5,058 | not reported | not reported | 63,317 | No | Form 4 |
| Brennan David R | May 15, 2025 | May 19, 2025 | A | 5,058 | not reported | not reported | 126,933 | No | Form 4 |
| Smith Michael AlexanderChief Legal Officer | May 15, 2025 | May 19, 2025 | A | 5,578 | $0.00 | $0 | 97,372 | No | Form 4 |
| Smith Michael AlexanderChief Legal Officer | May 15, 2025 | May 19, 2025 | A · derivative | 27,100 | $67.22 | $1,821,662 | 27,100 | No | Form 4 |
| Flammer Martina M.D.Chief Medical Officer | May 15, 2025 | May 19, 2025 | A | 6,508 | $0.00 | $0 | 96,521 | Yes | Form 4 |
| Flammer Martina M.D.Chief Medical Officer | May 15, 2025 | May 19, 2025 | S | 9,925 | $65.47 | Sale −$649,790 | 86,596 | Yes | Form 4 |
| Flammer Martina M.D.Chief Medical Officer | May 15, 2025 | May 19, 2025 | A · derivative | 31,610 | $67.22 | $2,124,824 | 31,610 | Yes | Form 4 |
| Lewis WilliamChair and CEO | May 15, 2025 | May 19, 2025 | A | 22,314 | $0.00 | $0 | 335,287 | No | Form 4 |
| Lewis WilliamChair and CEO | May 15, 2025 | May 19, 2025 | A · derivative | 108,380 | $67.22 | $7,285,304 | 108,380 | No | Form 4 |
| Schaeffer Orlov S NicoleChief People Strategy Officer | May 15, 2025 | May 19, 2025 | A | 5,578 | $0.00 | $0 | 120,221 | No | Form 4 |
| Schaeffer Orlov S NicoleChief People Strategy Officer | May 15, 2025 | May 19, 2025 | A · derivative | 27,100 | $67.22 | $1,821,662 | 27,100 | No | Form 4 |
| Adsett RogerChief Operating Officer | May 15, 2025 | May 19, 2025 | A | 6,508 | $0.00 | $0 | 143,183 | No | Form 4 |
| Adsett RogerChief Operating Officer | May 15, 2025 | May 19, 2025 | A · derivative | 31,610 | $67.22 | $2,124,824 | 31,610 | No | Form 4 |
| Bonstein SaraChief Financial Officer | May 15, 2025 | May 19, 2025 | A | 6,508 | $0.00 | $0 | 114,867 | No | Form 4 |