IONSIONIS PHARMACEUTICALS INC
- Market cap
- $7.13B
- as of 2026-10-23
- Latest close
- $42.93
- as of 2026-10-23
- Sector
- Healthcare
- as of 2026-10-24
- Industry
- Biotechnology
- as of 2026-10-24
Cluster
No cluster in the last 90 days under the default rule (14d · ≥2 insiders · all roles).
Form 4 historysince 2023-10-16
Dashed line = amended filing (Form 4/A)
Showing the latest 500 of 938 transactions.
| Insider | Traded | Filed | Type | Shares | Price | Value | Owned after | 10b5-1 plan | Filing |
|---|---|---|---|---|---|---|---|---|---|
| Devers Shannon L.EVP, Chief Human Resources Ofc | Oct 16 | Oct 19 | S | 1,357 | $43.54 | Sale −$59,082 | 17,811 | No | Form 4 |
| Swayze EricEVP Research | Oct 16 | Oct 19 | S | 53 | $43.54 | Sale −$2,308 | 390 | No | Form 4 |
| Devers Shannon L.EVP, Chief Human Resources Ofc | Oct 15 | Oct 19 | M | 2,820 | $0.00 | $0 | 19,168 | No | Form 4 |
| Devers Shannon L.EVP, Chief Human Resources Ofc | Oct 15 | Oct 19 | M · derivative | 2,820 | $0.00 | $0 | 49,884 | No | Form 4 |
| Swayze EricEVP Research | Oct 15 | Oct 19 | M | 125 | $0.00 | $0 | 443 | No | Form 4 |
| Swayze EricEVP Research | Oct 15 | Oct 19 | M · derivative | 125 | $0.00 | $0 | 486 | No | Form 4 |
| Birchler BrianEVP, Corp and Development Ops | Aug 31 | Sep 2 | J | 58 | $51.31 | $2,976 | 102,883 | No | Form 4 |
| Monia Brett PChief Executive Officer | Aug 31 | Sep 2 | J | 98 | $51.31 | $5,028 | 242,760 | No | Form 4 |
| O'Neil Patrick R.EVP CLO & General Counsel | Aug 31 | Sep 2 | J | 63 | $51.31 | $3,233 | 59,205 | No | Form 4 |
| Bennett C FrankEVP, Chief Scientific Officer | Aug 31 | Sep 2 | J | 110 | $51.31 | $5,644 | 60,128 | No | Form 4 |
| Hayden Michael R | Jul 31 | Jul 31 | P | 5,000 | $51.60 | Purchase +$258,000 | 24,000 | No | Form 4 |
| Hayden Michael R | Jul 30 | Jul 31 | P | 15,000 | $53.38 | Purchase +$800,700 | 19,000 | No | Form 4 |
| Berthelsen Spencer R | Jul 15 | Jul 17 | M | 5,220 | $0.00 | $0 | 161,233 | No | Form 4 |
| Berthelsen Spencer R | Jul 15 | Jul 17 | M · derivative | 5,220 | $0.00 | $0 | 2,301 | No | Form 4 |
| Herman Joan E | Jul 15 | Jul 17 | M | 5,220 | $0.00 | $0 | 51,306 | No | Form 4 |
| Herman Joan E | Jul 15 | Jul 17 | M · derivative | 5,220 | $0.00 | $0 | 2,301 | No | Form 4 |
| Hantson Ludwig | Jul 15 | Jul 17 | A · derivative | 3,399 | $0.00 | $0 | 3,399 | No | Form 4 |
| Reikes Peter N | Jul 15 | Jul 17 | A · derivative | 3,399 | $0.00 | $0 | 3,399 | No | Form 4 |
| Kordasiewicz Holly B.EVP, Chief Development Officer | Jul 7 | Jul 9 | S | 362 | $84.30 | Sale −$30,517 | 22,096 | Yes | Form 4 |
| Diaz Allene M. | Jul 7 | Jul 9 | M | 10,111 | $47.11 | $476,329 | 13,922 | Yes | Form 4 |
| Diaz Allene M. | Jul 7 | Jul 9 | S | 10,111 | $85.42 | Sale −$863,682 | 3,811 | Yes | Form 4 |
| Diaz Allene M. | Jul 7 | Jul 9 | M · derivative | 10,111 | $47.11 | $476,329 | not reported | Yes | Form 4 |
| Bennett C FrankEVP, Chief Scientific Officer | Jul 7 | Jul 9 | S | 5,536 | $83.58 | Sale −$462,699 | 75,018 | Yes | Form 4 |
| Bennett C FrankEVP, Chief Scientific Officer | Jul 7 | Jul 9 | J | 15,000 | $0.00 | $0 | 15,000 | Yes | Form 4 |
| Bennett C FrankEVP, Chief Scientific Officer | Jul 7 | Jul 9 | S | 15,000 | $85.46 | Sale −$1,281,900 | not reported | Yes | Form 4 |
| Bennett C FrankEVP, Chief Scientific Officer | Jul 7 | Jul 9 | J · derivative | 15,000 | $0.00 | $0 | 12,109 | Yes | Form 4 |
| Berthelsen Spencer R | Jul 1 | Jul 6 | A · derivative | 5,369 | $79.19 | $425,171 | 5,369 | No | Form 4 |
| Berthelsen Spencer R | Jul 1 | Jul 6 | A · derivative | 2,301 | $0.00 | $0 | 7,521 | No | Form 4 |
| Diaz Allene M. | Jul 1 | Jul 6 | A · derivative | 5,369 | $79.19 | $425,171 | 5,369 | No | Form 4 |
| Diaz Allene M. | Jul 1 | Jul 6 | A · derivative | 2,301 | $0.00 | $0 | 7,521 | No | Form 4 |
| Hayden Michael R | Jul 1 | Jul 6 | A · derivative | 5,369 | $79.19 | $425,171 | 5,369 | No | Form 4 |
| Hayden Michael R | Jul 1 | Jul 6 | A · derivative | 2,301 | $0.00 | $0 | 12,198 | No | Form 4 |
| Klein Joseph III | Jul 1 | Jul 6 | M | 11,518 | $39.94 | $460,029 | 22,532 | Yes | Form 4 |
| Klein Joseph III | Jul 1 | Jul 6 | S | 99 | $79.45 | Sale −$7,866 | 22,433 | Yes | Form 4 |
| Klein Joseph III | Jul 1 | Jul 6 | S | 11,419 | $79.04 | Sale −$902,558 | 11,014 | Yes | Form 4 |
| Klein Joseph III | Jul 1 | Jul 6 | M · derivative | 11,518 | $39.94 | $460,029 | not reported | Yes | Form 4 |
| Klein Joseph III | Jul 1 | Jul 6 | A · derivative | 5,369 | $79.19 | $425,171 | 5,369 | Yes | Form 4 |
| Klein Joseph III | Jul 1 | Jul 6 | A · derivative | 2,301 | $0.00 | $0 | 16,277 | Yes | Form 4 |
| Herman Joan E | Jul 1 | Jul 6 | A · derivative | 5,369 | $79.19 | $425,171 | 5,369 | No | Form 4 |
| Herman Joan E | Jul 1 | Jul 6 | A · derivative | 2,301 | $0.00 | $0 | 7,521 | No | Form 4 |
| Loscalzo Joseph | Jul 1 | Jul 6 | A · derivative | 5,369 | $79.19 | $425,171 | 5,369 | No | Form 4 |
| Loscalzo Joseph | Jul 1 | Jul 6 | A · derivative | 2,301 | $0.00 | $0 | 7,521 | No | Form 4 |
| Yang Michael J. | Jul 1 | Jul 6 | A · derivative | 5,369 | $79.19 | $425,171 | 5,369 | No | Form 4 |
| Yang Michael J. | Jul 1 | Jul 6 | A · derivative | 2,301 | $0.00 | $0 | 9,451 | No | Form 4 |
| Schneider EugeneEVP, Chf Clinical Develop Ofcr | Jun 26 | Jun 30 | M | 26,000 | $60.89 | $1,583,140 | 103,114 | Yes | Form 4 |
| Schneider EugeneEVP, Chf Clinical Develop Ofcr | Jun 26 | Jun 30 | S | 26,000 | $81.05 | Sale −$2,107,300 | 77,114 | Yes | Form 4 |
| Schneider EugeneEVP, Chf Clinical Develop Ofcr | Jun 26 | Jun 30 | M · derivative | 26,000 | $60.89 | $1,583,140 | 26,000 | Yes | Form 4 |
| O'Neil Patrick R.EVP CLO & General Counsel | Jun 26 | Jun 30 | S | 3,069 | $80.00 | Sale −$245,520 | 61,470 | Yes | Form 4 |
| Baroldi JosephEVP, Chief Business Officer | Jun 26 | Jun 30 | M | 3,866 | $56.78 | $219,511 | 8,535 | Yes | Form 4 |
| Baroldi JosephEVP, Chief Business Officer | Jun 26 | Jun 30 | M | 1,769 | $32.60 | $57,669 | 10,304 | Yes | Form 4 |
| Baroldi JosephEVP, Chief Business Officer | Jun 26 | Jun 30 | S | 5,635 | $80.16 | Sale −$451,702 | 4,669 | Yes | Form 4 |
| Baroldi JosephEVP, Chief Business Officer | Jun 26 | Jun 30 | M · derivative | 1,769 | $32.60 | $57,669 | not reported | Yes | Form 4 |
| Baroldi JosephEVP, Chief Business Officer | Jun 26 | Jun 30 | M · derivative | 3,866 | $56.78 | $219,511 | not reported | Yes | Form 4 |
| Monia Brett PChief Executive Officer | Jun 26 | Jun 26 | M | 50,000 | $56.78 | $2,839,000 | 295,571 | Yes | Form 4 |
| Monia Brett PChief Executive Officer | Jun 26 | Jun 26 | S | 50,000 | $80.59 | Sale −$4,029,500 | 245,571 | Yes | Form 4 |
| Monia Brett PChief Executive Officer | Jun 26 | Jun 26 | M · derivative | 50,000 | $56.78 | $2,839,000 | 99,872 | Yes | Form 4 |
| Swayze EricEVP Research | Jun 25 | Jun 26 | S | 10,602 | $79.18 | Sale −$839,466 | 21,759 | Yes | Form 4 |
| Monia Brett PChief Executive Officer | Jun 25 | Jun 26 | M | 21,072 | $32.60 | $686,947 | 266,643 | Yes | Form 4 |
| Monia Brett PChief Executive Officer | Jun 25 | Jun 26 | S | 21,072 | $78.49 | Sale −$1,653,941 | 245,571 | Yes | Form 4 |
| Monia Brett PChief Executive Officer | Jun 25 | Jun 26 | M · derivative | 21,072 | $32.60 | $686,947 | not reported | Yes | Form 4 |
| Monia Brett PChief Executive Officer | Jun 24 | Jun 26 | M | 14,565 | $32.60 | $474,819 | 260,136 | Yes | Form 4 |
| Monia Brett PChief Executive Officer | Jun 24 | Jun 26 | S | 14,565 | $78.41 | Sale −$1,142,042 | 245,571 | Yes | Form 4 |
| Monia Brett PChief Executive Officer | Jun 24 | Jun 26 | M · derivative | 14,565 | $32.60 | $474,819 | 21,072 | Yes | Form 4 |
| Berthelsen Spencer R | Jun 15 | Jun 16 | M | 8,000 | $24.42 | $195,360 | 164,013 | Yes | Form 4 |
| Berthelsen Spencer R | Jun 15 | Jun 16 | S | 8,000 | $73.49 | Sale −$587,920 | 156,013 | Yes | Form 4 |
| Berthelsen Spencer R | Jun 15 | Jun 16 | M · derivative | 8,000 | $24.42 | $195,360 | not reported | Yes | Form 4 |
| Kordasiewicz Holly B.EVP, Chief Development Officer | Jun 12 | Jun 16 | M | 7,951 | $60.89 | $484,136 | 30,409 | Yes | Form 4 |
| Kordasiewicz Holly B.EVP, Chief Development Officer | Jun 12 | Jun 16 | M | 21,000 | $60.89 | $1,278,690 | 51,409 | Yes | Form 4 |
| Kordasiewicz Holly B.EVP, Chief Development Officer | Jun 12 | Jun 16 | M | 12,000 | $32.60 | $391,200 | 63,409 | Yes | Form 4 |
| Kordasiewicz Holly B.EVP, Chief Development Officer | Jun 12 | Jun 16 | M | 19,895 | $56.78 | $1,129,638 | 83,304 | Yes | Form 4 |
| Kordasiewicz Holly B.EVP, Chief Development Officer | Jun 12 | Jun 16 | S | 41,004 | $73.09 | Sale −$2,996,982 | 42,300 | Yes | Form 4 |
| Kordasiewicz Holly B.EVP, Chief Development Officer | Jun 12 | Jun 16 | S | 19,842 | $74.05 | Sale −$1,469,300 | 22,458 | Yes | Form 4 |
| Kordasiewicz Holly B.EVP, Chief Development Officer | Jun 12 | Jun 16 | M · derivative | 12,000 | $32.60 | $391,200 | not reported | Yes | Form 4 |
| Kordasiewicz Holly B.EVP, Chief Development Officer | Jun 12 | Jun 16 | M · derivative | 19,895 | $56.78 | $1,129,638 | not reported | Yes | Form 4 |
| Kordasiewicz Holly B.EVP, Chief Development Officer | Jun 12 | Jun 16 | M · derivative | 7,951 | $60.89 | $484,136 | 21,000 | Yes | Form 4 |
| Kordasiewicz Holly B.EVP, Chief Development Officer | Jun 12 | Jun 16 | M · derivative | 21,000 | $60.89 | $1,278,690 | not reported | Yes | Form 4 |
| Hantson Ludwig | Jun 4 | Jun 8 | A · derivative | 10,753 | $75.13 | $807,873 | 10,753 | No | Form 4 |
| Reikes Peter N | Jun 4 | Jun 8 | A · derivative | 10,753 | $75.13 | $807,873 | 10,753 | No | Form 4 |
| Berthelsen Spencer R | Jun 1 | Jun 3 | M | 8,000 | $24.42 | $195,360 | 164,013 | Yes | Form 4 |
| Berthelsen Spencer R | Jun 1 | Jun 3 | S | 8,000 | $75.67 | Sale −$605,360 | 156,013 | Yes | Form 4 |
| Berthelsen Spencer R | Jun 1 | Jun 3 | M · derivative | 8,000 | $24.42 | $195,360 | 8,000 | Yes | Form 4 |
| Monia Brett PChief Executive Officer | May 14 | May 15 | M | 3,220 | $32.60 | $104,972 | 245,882 | Yes | Form 4 |
| Monia Brett PChief Executive Officer | May 14 | May 15 | S | 3,220 | $78.68 | Sale −$253,350 | 242,662 | Yes | Form 4 |
| Monia Brett PChief Executive Officer | May 14 | May 15 | M · derivative | 3,220 | $32.60 | $104,972 | 35,637 | Yes | Form 4 |
| Monia Brett PChief Executive Officer | May 13 | May 15 | M | 1,316 | $32.60 | $42,902 | 243,978 | Yes | Form 4 |
| Monia Brett PChief Executive Officer | May 13 | May 15 | S | 1,316 | $78.01 | Sale −$102,661 | 242,662 | Yes | Form 4 |
| Monia Brett PChief Executive Officer | May 13 | May 15 | M · derivative | 1,316 | $32.60 | $42,902 | 38,857 | Yes | Form 4 |
| Loscalzo Joseph | May 4 | May 6 | M | 10,968 | $38.06 | $417,442 | 47,298 | Yes | Form 4 |
| Loscalzo Joseph | May 4 | May 6 | M | 12,000 | $40.05 | $480,600 | 59,298 | Yes | Form 4 |
| Loscalzo Joseph | May 4 | May 6 | M | 10,321 | $41.08 | $423,987 | 69,619 | Yes | Form 4 |
| Loscalzo Joseph | May 4 | May 6 | M | 16,000 | $42.88 | $686,080 | 85,619 | Yes | Form 4 |
| Loscalzo Joseph | May 4 | May 6 | M | 12,000 | $60.20 | $722,400 | 97,619 | Yes | Form 4 |
| Loscalzo Joseph | May 4 | May 6 | M | 16,000 | $64.80 | $1,036,800 | 113,619 | Yes | Form 4 |
| Loscalzo Joseph | May 4 | May 6 | S | 59,508 | $74.90 | Sale −$4,457,149 | 54,111 | Yes | Form 4 |
| Loscalzo Joseph | May 4 | May 6 | S | 17,781 | $75.58 | Sale −$1,343,888 | 36,330 | Yes | Form 4 |
| Loscalzo Joseph | May 4 | May 6 | M · derivative | 10,968 | $38.06 | $417,442 | not reported | Yes | Form 4 |
| Loscalzo Joseph | May 4 | May 6 | M · derivative | 12,000 | $40.05 | $480,600 | not reported | Yes | Form 4 |
| Loscalzo Joseph | May 4 | May 6 | M · derivative | 10,321 | $41.08 | $423,987 | not reported | Yes | Form 4 |
| Loscalzo Joseph | May 4 | May 6 | M · derivative | 16,000 | $42.88 | $686,080 | not reported | Yes | Form 4 |
| Loscalzo Joseph | May 4 | May 6 | M · derivative | 12,000 | $60.20 | $722,400 | not reported | Yes | Form 4 |
| Loscalzo Joseph | May 4 | May 6 | M · derivative | 16,000 | $64.80 | $1,036,800 | not reported | Yes | Form 4 |
| Klein Joseph III | May 1 | May 5 | M | 10,111 | $47.11 | $476,329 | 21,125 | Yes | Form 4 |
| Klein Joseph III | May 1 | May 5 | S | 8,680 | $73.35 | Sale −$636,678 | 12,445 | Yes | Form 4 |
| Klein Joseph III | May 1 | May 5 | S | 1,431 | $74.45 | Sale −$106,538 | 11,014 | Yes | Form 4 |
| Klein Joseph III | May 1 | May 5 | M · derivative | 10,111 | $47.11 | $476,329 | not reported | Yes | Form 4 |
| Baroldi JosephEVP, Chief Business Officer | Apr 28 | Apr 30 | S | 1,626 | $71.79 | Sale −$116,731 | 44,909 | Yes | Form 4 |
| Baroldi JosephEVP, Chief Business Officer | Apr 16 | Apr 17 | S | 5,619 | $74.56 | Sale −$418,953 | 46,535 | No | Form 4 |
| Birchler BrianEVP, Corp and Development Ops | Apr 16 | Apr 17 | S | 973 | $75.04 | Sale −$73,014 | 67,500 | No | Form 4 |
| Jenne KyleEVP, Chf GL Pdt Str Ofcr | Apr 16 | Apr 17 | S | 4,902 | $75.17 | Sale −$368,483 | 23,713 | No | Form 4 |
| Baroldi JosephEVP, Chief Business Officer | Apr 15 | Apr 17 | M | 10,837 | $0.00 | $0 | 52,154 | No | Form 4 |
| Baroldi JosephEVP, Chief Business Officer | Apr 15 | Apr 17 | M · derivative | 10,837 | $0.00 | $0 | 48,312 | No | Form 4 |
| Birchler BrianEVP, Corp and Development Ops | Apr 15 | Apr 17 | M | 1,875 | $0.00 | $0 | 68,473 | No | Form 4 |
| Birchler BrianEVP, Corp and Development Ops | Apr 15 | Apr 17 | M · derivative | 1,875 | $0.00 | $0 | 48,926 | No | Form 4 |
| Jenne KyleEVP, Chf GL Pdt Str Ofcr | Apr 15 | Apr 17 | M | 12,226 | $0.00 | $0 | 28,615 | No | Form 4 |
| Jenne KyleEVP, Chf GL Pdt Str Ofcr | Apr 15 | Apr 17 | M · derivative | 12,226 | $0.00 | $0 | 74,402 | No | Form 4 |
| Parshall B Lynne | Apr 15 | Apr 17 | S | 4,466 | $76.19 | Sale −$340,265 | 51,878 | Yes | Form 4 |
| Parshall B Lynne | Apr 15 | Apr 17 | S | 534 | $76.97 | Sale −$41,102 | 51,344 | Yes | Form 4 |
| Devers Shannon L.EVP, Chief Human Resources Ofc | Apr 2 | Apr 2 | S | 6,193 | $74.05 | Sale −$458,592 | 16,348 | Yes | Form 4 |
| Klein Joseph III | Apr 1 | Apr 2 | M | 12,000 | $38.06 | $456,720 | 23,014 | Yes | Form 4 |
| Klein Joseph III | Apr 1 | Apr 2 | M | 10,321 | $41.08 | $423,987 | 33,335 | Yes | Form 4 |
| Klein Joseph III | Apr 1 | Apr 2 | S | 20,105 | $75.50 | Sale −$1,517,928 | 13,230 | Yes | Form 4 |
| Klein Joseph III | Apr 1 | Apr 2 | S | 2,216 | $75.95 | Sale −$168,305 | 11,014 | Yes | Form 4 |
| Klein Joseph III | Apr 1 | Apr 2 | M · derivative | 12,000 | $38.06 | $456,720 | not reported | Yes | Form 4 |
| Klein Joseph III | Apr 1 | Apr 2 | M · derivative | 10,321 | $41.08 | $423,987 | not reported | Yes | Form 4 |
| Schneider EugeneEVP, Chf Clinical Develop Ofcr | Mar 19 | Mar 23 | S | 5,812 | $70.97 | Sale −$412,478 | 63,890 | Yes | Form 4 |
| Hougen Elizabeth LEVP, Finance & CFO | Mar 17 | Mar 18 | S | 10,172 | $73.21 | Sale −$744,692 | 82,660 | Yes | Form 4 |
| Hougen Elizabeth LEVP, Finance & CFO | Mar 16 | Mar 18 | M | 60,299 | $60.89 | $3,671,606 | 193,180 | Yes | Form 4 |
| Hougen Elizabeth LEVP, Finance & CFO | Mar 16 | Mar 18 | M | 61,041 | $56.78 | $3,465,908 | 254,221 | Yes | Form 4 |
| Hougen Elizabeth LEVP, Finance & CFO | Mar 16 | Mar 18 | M | 33,118 | $32.60 | $1,079,647 | 287,339 | Yes | Form 4 |
| Hougen Elizabeth LEVP, Finance & CFO | Mar 16 | Mar 18 | M | 20,541 | $37.58 | $771,931 | 307,880 | Yes | Form 4 |
| Hougen Elizabeth LEVP, Finance & CFO | Mar 16 | Mar 18 | S | 205,608 | $72.38 | Sale −$14,881,907 | 102,272 | Yes | Form 4 |
| Hougen Elizabeth LEVP, Finance & CFO | Mar 16 | Mar 18 | S | 9,440 | $72.77 | Sale −$686,949 | 92,832 | Yes | Form 4 |
| Hougen Elizabeth LEVP, Finance & CFO | Mar 16 | Mar 18 | M · derivative | 33,118 | $32.60 | $1,079,647 | not reported | Yes | Form 4 |
| Hougen Elizabeth LEVP, Finance & CFO | Mar 16 | Mar 18 | M · derivative | 20,541 | $37.58 | $771,931 | 5,405 | Yes | Form 4 |
| Hougen Elizabeth LEVP, Finance & CFO | Mar 16 | Mar 18 | M · derivative | 61,041 | $56.78 | $3,465,908 | not reported | Yes | Form 4 |
| Hougen Elizabeth LEVP, Finance & CFO | Mar 16 | Mar 18 | M · derivative | 60,299 | $60.89 | $3,671,606 | not reported | Yes | Form 4 |
| Jenne KyleEVP, Chf GL Pdt Str Ofcr | Mar 10 | Mar 11 | M | 32,602 | $46.10 | $1,502,952 | 48,991 | Yes | Form 4 |
| Jenne KyleEVP, Chf GL Pdt Str Ofcr | Mar 10 | Mar 11 | S | 21,191 | $75.50 | Sale −$1,599,921 | 27,800 | Yes | Form 4 |
| Jenne KyleEVP, Chf GL Pdt Str Ofcr | Mar 10 | Mar 11 | S | 16,086 | $76.30 | Sale −$1,227,362 | 11,714 | Yes | Form 4 |
| Jenne KyleEVP, Chf GL Pdt Str Ofcr | Mar 10 | Mar 11 | M | 4,675 | $34.69 | $162,176 | 16,389 | Yes | Form 4 |
| Jenne KyleEVP, Chf GL Pdt Str Ofcr | Mar 10 | Mar 11 | M · derivative | 4,675 | $34.69 | $162,176 | 14,025 | Yes | Form 4 |
| Jenne KyleEVP, Chf GL Pdt Str Ofcr | Mar 10 | Mar 11 | M · derivative | 32,602 | $46.10 | $1,502,952 | 32,601 | Yes | Form 4 |
| Monia Brett PChief Executive Officer | Mar 10 | Mar 11 | M | 34,103 | $60.89 | $2,076,532 | 276,765 | Yes | Form 4 |
| Monia Brett PChief Executive Officer | Mar 10 | Mar 11 | S | 16,512 | $75.47 | Sale −$1,246,161 | 260,253 | Yes | Form 4 |
| Monia Brett PChief Executive Officer | Mar 10 | Mar 11 | S | 17,591 | $76.34 | Sale −$1,342,897 | 242,662 | Yes | Form 4 |
| Monia Brett PChief Executive Officer | Mar 10 | Mar 11 | M · derivative | 34,103 | $60.89 | $2,076,532 | not reported | Yes | Form 4 |
| Monia Brett PChief Executive Officer | Mar 9 | Mar 11 | M | 40,822 | $60.89 | $2,485,652 | 295,803 | Yes | Form 4 |
| Monia Brett PChief Executive Officer | Mar 9 | Mar 11 | M | 73,529 | $60.89 | $4,477,181 | 369,332 | Yes | Form 4 |
| Monia Brett PChief Executive Officer | Mar 9 | Mar 11 | S | 7,382 | $74.11 | Sale −$547,080 | 361,950 | Yes | Form 4 |
| Monia Brett PChief Executive Officer | Mar 9 | Mar 11 | S | 117,604 | $75.26 | Sale −$8,850,877 | 244,346 | Yes | Form 4 |
| Monia Brett PChief Executive Officer | Mar 9 | Mar 11 | S | 1,684 | $75.58 | Sale −$127,277 | 242,662 | Yes | Form 4 |
| Monia Brett PChief Executive Officer | Mar 9 | Mar 11 | M · derivative | 40,822 | $60.89 | $2,485,652 | 107,632 | Yes | Form 4 |
| Monia Brett PChief Executive Officer | Mar 9 | Mar 11 | M · derivative | 73,529 | $60.89 | $4,477,181 | 34,103 | Yes | Form 4 |
| O'Neil Patrick R.EVP CLO & General Counsel | Mar 9 | Mar 11 | S | 10,148 | $75.25 | Sale −$763,637 | 62,211 | Yes | Form 4 |
| Baroldi JosephEVP, Chief Business Officer | Mar 4 | Mar 5 | M | 238 | $56.78 | $13,514 | 4,585 | Yes | Form 4 |
| Baroldi JosephEVP, Chief Business Officer | Mar 4 | Mar 5 | S | 238 | $80.00 | Sale −$19,040 | 4,347 | Yes | Form 4 |
| Baroldi JosephEVP, Chief Business Officer | Mar 4 | Mar 5 | M | 201 | $32.60 | $6,553 | 4,548 | Yes | Form 4 |
| Baroldi JosephEVP, Chief Business Officer | Mar 4 | Mar 5 | S | 201 | $80.00 | Sale −$16,080 | 4,347 | Yes | Form 4 |
| Baroldi JosephEVP, Chief Business Officer | Mar 4 | Mar 5 | M · derivative | 201 | $32.60 | $6,553 | 1,769 | Yes | Form 4 |
| Baroldi JosephEVP, Chief Business Officer | Mar 4 | Mar 5 | M · derivative | 238 | $56.78 | $13,514 | 3,866 | Yes | Form 4 |
| Loscalzo Joseph | Mar 4 | Mar 5 | M | 200 | $38.06 | $7,612 | 36,530 | Yes | Form 4 |
| Loscalzo Joseph | Mar 4 | Mar 5 | S | 200 | $80.00 | Sale −$16,000 | 36,330 | Yes | Form 4 |
| Loscalzo Joseph | Mar 4 | Mar 5 | M · derivative | 200 | $38.06 | $7,612 | 10,968 | Yes | Form 4 |
| Baroldi JosephEVP, Chief Business Officer | Mar 3 | Mar 5 | S | 4,096 | $79.36 | Sale −$325,059 | 41,317 | Yes | Form 4 |
| Baroldi JosephEVP, Chief Business Officer | Mar 3 | Mar 5 | M | 820 | $56.78 | $46,560 | 5,592 | Yes | Form 4 |
| Baroldi JosephEVP, Chief Business Officer | Mar 3 | Mar 5 | M | 879 | $32.60 | $28,655 | 6,471 | Yes | Form 4 |
| Baroldi JosephEVP, Chief Business Officer | Mar 3 | Mar 5 | S | 2,088 | $80.41 | Sale −$167,896 | 4,383 | Yes | Form 4 |
| Baroldi JosephEVP, Chief Business Officer | Mar 3 | Mar 5 | S | 36 | $81.01 | Sale −$2,916 | 4,347 | Yes | Form 4 |
| Baroldi JosephEVP, Chief Business Officer | Mar 3 | Mar 5 | M · derivative | 879 | $32.60 | $28,655 | 1,970 | Yes | Form 4 |
| Baroldi JosephEVP, Chief Business Officer | Mar 3 | Mar 5 | M · derivative | 820 | $56.78 | $46,560 | 4,104 | Yes | Form 4 |
| Bennett C FrankEVP, Chief Scientific Officer | Mar 3 | Mar 5 | M | 16,463 | $32.60 | $536,694 | 117,017 | Yes | Form 4 |
| Bennett C FrankEVP, Chief Scientific Officer | Mar 3 | Mar 5 | M | 48,626 | $60.89 | $2,960,837 | 165,643 | Yes | Form 4 |
| Bennett C FrankEVP, Chief Scientific Officer | Mar 3 | Mar 5 | S | 71,600 | $79.10 | Sale −$5,663,560 | 94,043 | Yes | Form 4 |
| Bennett C FrankEVP, Chief Scientific Officer | Mar 3 | Mar 5 | S | 12,687 | $79.88 | Sale −$1,013,438 | 81,356 | Yes | Form 4 |
| Bennett C FrankEVP, Chief Scientific Officer | Mar 3 | Mar 5 | S | 802 | $80.76 | Sale −$64,770 | 80,554 | Yes | Form 4 |
| Bennett C FrankEVP, Chief Scientific Officer | Mar 3 | Mar 5 | M · derivative | 16,463 | $32.60 | $536,694 | 2,406 | Yes | Form 4 |
| Bennett C FrankEVP, Chief Scientific Officer | Mar 3 | Mar 5 | M · derivative | 48,626 | $60.89 | $2,960,837 | not reported | Yes | Form 4 |
| Devers Shannon L.EVP, Chief Human Resources Ofc | Mar 3 | Mar 5 | M | 3,510 | $37.58 | $131,906 | 26,051 | Yes | Form 4 |
| Devers Shannon L.EVP, Chief Human Resources Ofc | Mar 3 | Mar 5 | M | 3,760 | $40.85 | $153,596 | 29,811 | Yes | Form 4 |
| Devers Shannon L.EVP, Chief Human Resources Ofc | Mar 3 | Mar 5 | M | 5,500 | $34.69 | $190,795 | 35,311 | Yes | Form 4 |
| Devers Shannon L.EVP, Chief Human Resources Ofc | Mar 3 | Mar 5 | M | 6,951 | $32.60 | $226,603 | 42,262 | Yes | Form 4 |
| Devers Shannon L.EVP, Chief Human Resources Ofc | Mar 3 | Mar 5 | M | 385 | $52.87 | $20,355 | 42,647 | Yes | Form 4 |
| Devers Shannon L.EVP, Chief Human Resources Ofc | Mar 3 | Mar 5 | S | 14,321 | $79.12 | Sale −$1,133,078 | 28,326 | Yes | Form 4 |
| Devers Shannon L.EVP, Chief Human Resources Ofc | Mar 3 | Mar 5 | S | 5,030 | $80.00 | Sale −$402,400 | 23,296 | Yes | Form 4 |
| Devers Shannon L.EVP, Chief Human Resources Ofc | Mar 3 | Mar 5 | S | 755 | $80.84 | Sale −$61,034 | 22,541 | Yes | Form 4 |
| Devers Shannon L.EVP, Chief Human Resources Ofc | Mar 3 | Mar 5 | M · derivative | 6,951 | $32.60 | $226,603 | 928 | Yes | Form 4 |
| Devers Shannon L.EVP, Chief Human Resources Ofc | Mar 3 | Mar 5 | M · derivative | 5,500 | $34.69 | $190,795 | 16,500 | Yes | Form 4 |
| Devers Shannon L.EVP, Chief Human Resources Ofc | Mar 3 | Mar 5 | M · derivative | 3,510 | $37.58 | $131,906 | 5,744 | Yes | Form 4 |
| Devers Shannon L.EVP, Chief Human Resources Ofc | Mar 3 | Mar 5 | M · derivative | 3,760 | $40.85 | $153,596 | 11,280 | Yes | Form 4 |
| Devers Shannon L.EVP, Chief Human Resources Ofc | Mar 3 | Mar 5 | M · derivative | 385 | $52.87 | $20,355 | 8,877 | Yes | Form 4 |
| Diaz Allene M. | Mar 3 | Mar 5 | M | 10,321 | $41.08 | $423,987 | 28,689 | Yes | Form 4 |
| Diaz Allene M. | Mar 3 | Mar 5 | M | 12,000 | $38.06 | $456,720 | 40,689 | Yes | Form 4 |
| Diaz Allene M. | Mar 3 | Mar 5 | M | 18,000 | $40.05 | $720,900 | 58,689 | Yes | Form 4 |
| Diaz Allene M. | Mar 3 | Mar 5 | S | 39,265 | $79.11 | Sale −$3,106,254 | 19,424 | Yes | Form 4 |
| Diaz Allene M. | Mar 3 | Mar 5 | S | 14,608 | $79.88 | Sale −$1,166,887 | 4,816 | Yes | Form 4 |
| Diaz Allene M. | Mar 3 | Mar 5 | S | 1,005 | $80.80 | Sale −$81,204 | 3,811 | Yes | Form 4 |
| Diaz Allene M. | Mar 3 | Mar 5 | M · derivative | 12,000 | $38.06 | $456,720 | not reported | Yes | Form 4 |
| Diaz Allene M. | Mar 3 | Mar 5 | M · derivative | 18,000 | $40.05 | $720,900 | not reported | Yes | Form 4 |
| Diaz Allene M. | Mar 3 | Mar 5 | M · derivative | 10,321 | $41.08 | $423,987 | not reported | Yes | Form 4 |
| Klein Joseph III | Mar 3 | Mar 5 | M | 12,000 | $40.05 | $480,600 | 28,346 | Yes | Form 4 |
| Klein Joseph III | Mar 3 | Mar 5 | M | 4,000 | $42.88 | $171,520 | 32,346 | Yes | Form 4 |
| Klein Joseph III | Mar 3 | Mar 5 | S | 13,526 | $79.17 | Sale −$1,070,853 | 18,820 | Yes | Form 4 |
| Klein Joseph III | Mar 3 | Mar 5 | S | 6,794 | $80.00 | Sale −$543,520 | 12,026 | Yes | Form 4 |
| Klein Joseph III | Mar 3 | Mar 5 | S | 1,012 | $80.82 | Sale −$81,790 | 11,014 | Yes | Form 4 |
| Klein Joseph III | Mar 3 | Mar 5 | M · derivative | 12,000 | $40.05 | $480,600 | not reported | Yes | Form 4 |
| Klein Joseph III | Mar 3 | Mar 5 | M · derivative | 4,000 | $42.88 | $171,520 | not reported | Yes | Form 4 |
| Loscalzo Joseph | Mar 3 | Mar 5 | M | 832 | $38.06 | $31,666 | 37,162 | Yes | Form 4 |
| Loscalzo Joseph | Mar 3 | Mar 5 | S | 832 | $80.33 | Sale −$66,835 | 36,330 | Yes | Form 4 |
| Loscalzo Joseph | Mar 3 | Mar 5 | M · derivative | 832 | $38.06 | $31,666 | 11,168 | Yes | Form 4 |
| Bennett C FrankEVP, Chief Scientific Officer | Feb 27 | Mar 3 | J | 261 | $48.87 | $12,755 | 100,554 | No | Form 4 |
| Birchler BrianEVP, Corp and Development Ops | Feb 27 | Mar 3 | J | 351 | $48.87 | $17,153 | 66,598 | No | Form 4 |
| Monia Brett PChief Executive Officer | Feb 27 | Mar 3 | J | 484 | $48.87 | $23,653 | 254,981 | No | Form 4 |
| O'Neil Patrick R.EVP CLO & General Counsel | Feb 27 | Mar 3 | J | 376 | $48.87 | $18,375 | 72,359 | No | Form 4 |
| Swayze EricEVP Research | Feb 27 | Mar 3 | J | 256 | $48.87 | $12,511 | 32,361 | No | Form 4 |
| Swayze EricEVP Research | Feb 13 | Feb 13 | S | 9,435 | $81.56 | Sale −$769,519 | 38,312 | Yes | Form 4 |
| Swayze EricEVP Research | Feb 13 | Feb 13 | S | 6,207 | $82.07 | Sale −$509,408 | 32,105 | Yes | Form 4 |
| Parshall B Lynne | Feb 11 | Feb 13 | S | 5,000 | $82.72 | Sale −$413,600 | 56,344 | Yes | Form 4 |
| Bennett C FrankEVP, Chief Scientific Officer | Feb 2 | Feb 134/A | J | 0 | $0.00 | $0 | 100,293 | No | Form 4/A |
| Monia Brett PChief Executive Officer | Feb 6 | Feb 10 | S | 29,430 | $85.79 | Sale −$2,524,800 | 254,497 | Yes | Form 4 |
| Baroldi JosephEVP, Chief Business Officer | Jan 30 | Feb 2 | S | 5,296 | $82.96 | Sale −$439,356 | 45,413 | No | Form 4 |
| Bennett C FrankEVP, Chief Scientific Officer | Jan 30 | Feb 2 | S | 5,885 | $82.95 | Sale −$488,161 | 100,293 | No | Form 4 |
| Birchler BrianEVP, Corp and Development Ops | Jan 30 | Feb 2 | S | 6,179 | $83.03 | Sale −$513,042 | 66,247 | No | Form 4 |
| Hougen Elizabeth LEVP, Finance & CFO | Jan 30 | Feb 2 | S | 6,988 | $83.24 | Sale −$581,681 | 132,881 | No | Form 4 |
| Monia Brett PChief Executive Officer | Jan 30 | Feb 2 | S | 62,970 | $82.72 | Sale −$5,208,878 | 283,927 | No | Form 4 |
| O'Neil Patrick R.EVP CLO & General Counsel | Jan 30 | Feb 2 | S | 6,179 | $83.53 | Sale −$516,132 | 71,983 | No | Form 4 |
| Schneider EugeneEVP, Chf Clinical Develop Ofcr | Jan 30 | Feb 2 | S | 6,179 | $83.45 | Sale −$515,638 | 69,702 | No | Form 4 |
| Swayze EricEVP Research | Jan 30 | Feb 2 | S | 6,179 | $82.93 | Sale −$512,424 | 47,747 | No | Form 4 |
| Baroldi JosephEVP, Chief Business Officer | Jan 29 | Feb 2 | A | 10,278 | $0.00 | $0 | 50,709 | No | Form 4 |
| Bennett C FrankEVP, Chief Scientific Officer | Jan 29 | Feb 2 | A | 11,421 | $0.00 | $0 | 106,178 | No | Form 4 |
| Birchler BrianEVP, Corp and Development Ops | Jan 29 | Feb 2 | A | 11,991 | $0.00 | $0 | 72,426 | No | Form 4 |
| Hougen Elizabeth LEVP, Finance & CFO | Jan 29 | Feb 2 | A | 13,562 | $0.00 | $0 | 139,869 | No | Form 4 |
| Monia Brett PChief Executive Officer | Jan 29 | Feb 2 | A | 122,214 | $0.00 | $0 | 346,897 | No | Form 4 |
| O'Neil Patrick R.EVP CLO & General Counsel | Jan 29 | Feb 2 | A | 11,991 | $0.00 | $0 | 78,162 | No | Form 4 |
| Schneider EugeneEVP, Chf Clinical Develop Ofcr | Jan 29 | Feb 2 | A | 11,991 | $0.00 | $0 | 75,881 | No | Form 4 |
| Swayze EricEVP Research | Jan 29 | Feb 2 | A | 11,991 | $0.00 | $0 | 53,926 | No | Form 4 |
| Devers Shannon L.EVP, Chief Human Resources Ofc | Jan 22 | Jan 23 | S | 3,977 | $81.34 | Sale −$323,489 | 22,541 | Yes | Form 4 |
| Baroldi JosephEVP, Chief Business Officer | Jan 16 | Jan 20 | S | 6,907 | $75.75 | Sale −$523,205 | 40,431 | No | Form 4 |
| Baroldi JosephEVP, Chief Business Officer | Jan 16 | Jan 20 | S | 1,149 | $75.78 | Sale −$87,071 | 4,772 | No | Form 4 |
| Bennett C FrankEVP, Chief Scientific Officer | Jan 16 | Jan 20 | S | 8,977 | $75.15 | Sale −$674,622 | 94,757 | No | Form 4 |
| Birchler BrianEVP, Corp and Development Ops | Jan 16 | Jan 20 | S | 8,480 | $75.11 | Sale −$636,933 | 60,435 | No | Form 4 |
| Devers Shannon L.EVP, Chief Human Resources Ofc | Jan 16 | Jan 20 | S | 8,353 | $75.95 | Sale −$634,410 | 26,518 | No | Form 4 |
| Hougen Elizabeth LEVP, Finance & CFO | Jan 16 | Jan 20 | S | 12,922 | $75.22 | Sale −$971,993 | 126,307 | No | Form 4 |
| Jenne KyleEVP, Chf GL Pdt Str Ofcr | Jan 16 | Jan 20 | S | 1,823 | $75.96 | Sale −$138,475 | 16,389 | No | Form 4 |
| Kordasiewicz Holly B.EVP, Chief Development Officer | Jan 16 | Jan 20 | S | 4,141 | $75.66 | Sale −$313,308 | 14,718 | No | Form 4 |
| Monia Brett PChief Executive Officer | Jan 16 | Jan 20 | S | 44,034 | $74.82 | Sale −$3,294,624 | 224,683 | No | Form 4 |
| O'Neil Patrick R.EVP CLO & General Counsel | Jan 16 | Jan 20 | S | 9,191 | $75.84 | Sale −$697,045 | 66,171 | No | Form 4 |
| Schneider EugeneEVP, Chf Clinical Develop Ofcr | Jan 16 | Jan 20 | S | 9,302 | $75.59 | Sale −$703,138 | 63,890 | No | Form 4 |
| Swayze EricEVP Research | Jan 16 | Jan 20 | S | 9,884 | $75.34 | Sale −$744,661 | 41,935 | No | Form 4 |
| Swayze EricEVP Research | Jan 16 | Jan 20 | S | 49 | $75.97 | Sale −$3,723 | 318 | No | Form 4 |
| Baroldi JosephEVP, Chief Business Officer | Jan 15 | Jan 20 | M | 17,037 | $0.00 | $0 | 47,338 | No | Form 4 |
| Baroldi JosephEVP, Chief Business Officer | Jan 15 | Jan 20 | M | 2,850 | $0.00 | $0 | 5,921 | No | Form 4 |
| Baroldi JosephEVP, Chief Business Officer | Jan 15 | Jan 20 | A · derivative | 25,800 | $0.00 | $0 | 77,090 | No | Form 4 |
| Baroldi JosephEVP, Chief Business Officer | Jan 15 | Jan 20 | M · derivative | 17,037 | $0.00 | $0 | 49,474 | No | Form 4 |
| Baroldi JosephEVP, Chief Business Officer | Jan 15 | Jan 20 | A · derivative | 9,675 | $0.00 | $0 | 59,149 | No | Form 4 |
| Baroldi JosephEVP, Chief Business Officer | Jan 15 | Jan 20 | M · derivative | 2,850 | $0.00 | $0 | 5,474 | No | Form 4 |
| Baroldi JosephEVP, Chief Business Officer | Jan 15 | Jan 20 | A · derivative | 3,900 | $0.00 | $0 | 9,374 | No | Form 4 |
| Bennett C FrankEVP, Chief Scientific Officer | Jan 15 | Jan 20 | M | 21,055 | $0.00 | $0 | 103,734 | No | Form 4 |
| Bennett C FrankEVP, Chief Scientific Officer | Jan 15 | Jan 20 | A · derivative | 25,800 | $0.00 | $0 | 89,282 | No | Form 4 |
| Bennett C FrankEVP, Chief Scientific Officer | Jan 15 | Jan 20 | M · derivative | 21,055 | $0.00 | $0 | 17,434 | No | Form 4 |
| Bennett C FrankEVP, Chief Scientific Officer | Jan 15 | Jan 20 | A · derivative | 9,675 | $0.00 | $0 | 27,109 | No | Form 4 |
| Birchler BrianEVP, Corp and Development Ops | Jan 15 | Jan 20 | M | 20,089 | $0.00 | $0 | 68,915 | No | Form 4 |
| Birchler BrianEVP, Corp and Development Ops | Jan 15 | Jan 20 | A · derivative | 25,800 | $0.00 | $0 | 79,138 | No | Form 4 |
| Birchler BrianEVP, Corp and Development Ops | Jan 15 | Jan 20 | M · derivative | 20,089 | $0.00 | $0 | 41,126 | No | Form 4 |
| Birchler BrianEVP, Corp and Development Ops | Jan 15 | Jan 20 | A · derivative | 9,675 | $0.00 | $0 | 50,801 | No | Form 4 |
| Devers Shannon L.EVP, Chief Human Resources Ofc | Jan 15 | Jan 20 | M | 17,377 | $0.00 | $0 | 34,871 | No | Form 4 |
| Devers Shannon L.EVP, Chief Human Resources Ofc | Jan 15 | Jan 20 | A · derivative | 25,800 | $0.00 | $0 | 47,800 | No | Form 4 |
| Devers Shannon L.EVP, Chief Human Resources Ofc | Jan 15 | Jan 20 | M · derivative | 17,377 | $0.00 | $0 | 43,029 | No | Form 4 |
| Devers Shannon L.EVP, Chief Human Resources Ofc | Jan 15 | Jan 20 | A · derivative | 9,675 | $0.00 | $0 | 52,704 | No | Form 4 |
| Hougen Elizabeth LEVP, Finance & CFO | Jan 15 | Jan 20 | M | 28,729 | $0.00 | $0 | 139,229 | No | Form 4 |
| Hougen Elizabeth LEVP, Finance & CFO | Jan 15 | Jan 20 | A · derivative | 34,360 | $0.00 | $0 | 120,995 | No | Form 4 |
| Hougen Elizabeth LEVP, Finance & CFO | Jan 15 | Jan 20 | M · derivative | 28,729 | $0.00 | $0 | 55,940 | No | Form 4 |
| Hougen Elizabeth LEVP, Finance & CFO | Jan 15 | Jan 20 | A · derivative | 12,885 | $0.00 | $0 | 68,825 | No | Form 4 |
| Jenne KyleEVP, Chf GL Pdt Str Ofcr | Jan 15 | Jan 20 | M | 7,013 | $0.00 | $0 | 18,212 | No | Form 4 |
| Jenne KyleEVP, Chf GL Pdt Str Ofcr | Jan 15 | Jan 20 | A · derivative | 25,800 | $0.00 | $0 | 44,500 | No | Form 4 |
| Jenne KyleEVP, Chf GL Pdt Str Ofcr | Jan 15 | Jan 20 | A · derivative | 9,675 | $0.00 | $0 | 37,725 | No | Form 4 |
| Jenne KyleEVP, Chf GL Pdt Str Ofcr | Jan 15 | Jan 20 | M · derivative | 7,013 | $0.00 | $0 | 29,664 | No | Form 4 |
| Kordasiewicz Holly B.EVP, Chief Development Officer | Jan 15 | Jan 20 | M | 11,119 | $0.00 | $0 | 18,859 | No | Form 4 |
| Kordasiewicz Holly B.EVP, Chief Development Officer | Jan 15 | Jan 20 | M · derivative | 11,119 | $0.00 | $0 | 20,830 | No | Form 4 |
| Kordasiewicz Holly B.EVP, Chief Development Officer | Jan 15 | Jan 20 | A · derivative | 13,650 | $0.00 | $0 | 34,480 | No | Form 4 |
| Kordasiewicz Holly B.EVP, Chief Development Officer | Jan 15 | Jan 20 | A · derivative | 11,250 | $0.00 | $0 | 45,730 | No | Form 4 |
| Monia Brett PChief Executive Officer | Jan 15 | Jan 20 | M | 89,145 | $0.00 | $0 | 268,717 | No | Form 4 |
| Monia Brett PChief Executive Officer | Jan 15 | Jan 20 | A · derivative | 113,880 | $0.00 | $0 | 744,081 | No | Form 4 |
| Monia Brett PChief Executive Officer | Jan 15 | Jan 20 | M · derivative | 89,145 | $0.00 | $0 | 163,014 | No | Form 4 |
| Monia Brett PChief Executive Officer | Jan 15 | Jan 20 | A · derivative | 42,705 | $0.00 | $0 | 205,719 | No | Form 4 |
| O'Neil Patrick R.EVP CLO & General Counsel | Jan 15 | Jan 20 | M | 21,473 | $0.00 | $0 | 75,362 | No | Form 4 |
| O'Neil Patrick R.EVP CLO & General Counsel | Jan 15 | Jan 20 | A · derivative | 25,800 | $0.00 | $0 | 90,601 | No | Form 4 |
| O'Neil Patrick R.EVP CLO & General Counsel | Jan 15 | Jan 20 | M · derivative | 21,473 | $0.00 | $0 | 39,251 | No | Form 4 |
| O'Neil Patrick R.EVP CLO & General Counsel | Jan 15 | Jan 20 | A · derivative | 9,675 | $0.00 | $0 | 48,926 | No | Form 4 |
| Schneider EugeneEVP, Chf Clinical Develop Ofcr | Jan 15 | Jan 20 | M | 21,685 | $0.00 | $0 | 73,192 | No | Form 4 |
| Schneider EugeneEVP, Chf Clinical Develop Ofcr | Jan 15 | Jan 20 | A · derivative | 25,800 | $0.00 | $0 | 91,237 | No | Form 4 |
| Schneider EugeneEVP, Chf Clinical Develop Ofcr | Jan 15 | Jan 20 | M · derivative | 21,685 | $0.00 | $0 | 39,251 | No | Form 4 |
| Schneider EugeneEVP, Chf Clinical Develop Ofcr | Jan 15 | Jan 20 | A · derivative | 9,675 | $0.00 | $0 | 48,926 | No | Form 4 |
| Swayze EricEVP Research | Jan 15 | Jan 20 | M | 21,366 | $0.00 | $0 | 51,819 | No | Form 4 |
| Swayze EricEVP Research | Jan 15 | Jan 20 | M | 111 | $0.00 | $0 | 367 | No | Form 4 |
| Swayze EricEVP Research | Jan 15 | Jan 20 | A · derivative | 25,800 | $0.00 | $0 | 90,282 | No | Form 4 |
| Swayze EricEVP Research | Jan 15 | Jan 20 | M · derivative | 21,366 | $0.00 | $0 | 39,251 | No | Form 4 |
| Swayze EricEVP Research | Jan 15 | Jan 20 | A · derivative | 9,675 | $0.00 | $0 | 48,926 | No | Form 4 |
| Swayze EricEVP Research | Jan 15 | Jan 20 | M · derivative | 111 | $0.00 | $0 | 386 | No | Form 4 |
| Swayze EricEVP Research | Jan 15 | Jan 20 | A · derivative | 225 | $0.00 | $0 | 611 | No | Form 4 |
| Yang Michael J. | Jan 15 | Jan 20 | M | 1,930 | $0.00 | $0 | 7,940 | No | Form 4 |
| Yang Michael J. | Jan 15 | Jan 20 | M · derivative | 1,930 | $0.00 | $0 | 7,150 | No | Form 4 |
| Kordasiewicz Holly B.EVP, Chief Development Officer | Jan 2 | Jan 204/A | A · derivative | 7,500 | $79.67 | $597,525 | 16,600 | No | Form 4/A |
| Devers Shannon L.EVP, Chief Human Resources Ofc | Jan 7 | Jan 9 | M | 25,545 | $56.78 | $1,450,445 | 43,039 | Yes | Form 4 |
| Devers Shannon L.EVP, Chief Human Resources Ofc | Jan 7 | Jan 9 | S | 25,545 | $85.36 | Sale −$2,180,521 | 17,494 | Yes | Form 4 |
| Devers Shannon L.EVP, Chief Human Resources Ofc | Jan 7 | Jan 9 | M | 2,101 | $32.60 | $68,493 | 19,595 | Yes | Form 4 |
| Devers Shannon L.EVP, Chief Human Resources Ofc | Jan 7 | Jan 9 | S | 2,101 | $85.36 | Sale −$179,341 | 17,494 | Yes | Form 4 |
| Devers Shannon L.EVP, Chief Human Resources Ofc | Jan 7 | Jan 9 | M | 3,460 | $32.60 | $112,796 | 20,954 | Yes | Form 4 |
| Devers Shannon L.EVP, Chief Human Resources Ofc | Jan 7 | Jan 9 | S | 3,460 | $84.62 | Sale −$292,785 | 17,494 | Yes | Form 4 |
| Devers Shannon L.EVP, Chief Human Resources Ofc | Jan 7 | Jan 9 | M | 3,829 | $37.58 | $143,894 | 21,323 | Yes | Form 4 |
| Devers Shannon L.EVP, Chief Human Resources Ofc | Jan 7 | Jan 9 | S | 3,829 | $84.62 | Sale −$324,010 | 17,494 | Yes | Form 4 |
| Devers Shannon L.EVP, Chief Human Resources Ofc | Jan 7 | Jan 9 | M | 9,264 | $52.87 | $489,788 | 26,758 | Yes | Form 4 |
| Devers Shannon L.EVP, Chief Human Resources Ofc | Jan 7 | Jan 9 | S | 9,264 | $84.62 | Sale −$783,920 | 17,494 | Yes | Form 4 |
| Devers Shannon L.EVP, Chief Human Resources Ofc | Jan 7 | Jan 9 | M · derivative | 2,101 | $32.60 | $68,493 | 11,339 | Yes | Form 4 |
| Devers Shannon L.EVP, Chief Human Resources Ofc | Jan 7 | Jan 9 | M · derivative | 3,460 | $32.60 | $112,796 | 7,879 | Yes | Form 4 |
| Devers Shannon L.EVP, Chief Human Resources Ofc | Jan 7 | Jan 9 | M · derivative | 3,829 | $37.58 | $143,894 | 9,254 | Yes | Form 4 |
| Devers Shannon L.EVP, Chief Human Resources Ofc | Jan 7 | Jan 9 | M · derivative | 9,264 | $52.87 | $489,788 | 9,262 | Yes | Form 4 |
| Devers Shannon L.EVP, Chief Human Resources Ofc | Jan 7 | Jan 9 | M · derivative | 25,545 | $56.78 | $1,450,445 | 2,971 | Yes | Form 4 |
| Baroldi JosephEVP, Chief Business Officer | Jan 2 | Jan 6 | A · derivative | 19,350 | $79.67 | $1,541,615 | 19,350 | No | Form 4 |
| Baroldi JosephEVP, Chief Business Officer | Jan 2 | Jan 6 | A · derivative | 2,600 | $79.67 | $207,142 | 2,600 | No | Form 4 |
| Bennett C FrankEVP, Chief Scientific Officer | Jan 2 | Jan 6 | A · derivative | 19,350 | $79.67 | $1,541,615 | 19,350 | No | Form 4 |
| Birchler BrianEVP, Corp and Development Ops | Jan 2 | Jan 6 | A · derivative | 19,350 | $79.67 | $1,541,615 | 19,350 | No | Form 4 |
| Devers Shannon L.EVP, Chief Human Resources Ofc | Jan 2 | Jan 6 | A · derivative | 19,350 | $79.67 | $1,541,615 | 19,350 | No | Form 4 |
| Hougen Elizabeth LEVP, Finance & CFO | Jan 2 | Jan 6 | A · derivative | 25,770 | $79.67 | $2,053,096 | 25,770 | No | Form 4 |
| Monia Brett PChief Executive Officer | Jan 2 | Jan 6 | A · derivative | 85,410 | $79.67 | $6,804,615 | 85,410 | No | Form 4 |
| O'Neil Patrick R.EVP CLO & General Counsel | Jan 2 | Jan 6 | A · derivative | 19,350 | $79.67 | $1,541,615 | 19,350 | No | Form 4 |
| Schneider EugeneEVP, Chf Clinical Develop Ofcr | Jan 2 | Jan 6 | A · derivative | 19,350 | $79.67 | $1,541,615 | 19,350 | No | Form 4 |
| Swayze EricEVP Research | Jan 2 | Jan 6 | M | 5,125 | $60.89 | $312,061 | 35,578 | Yes | Form 4 |
| Swayze EricEVP Research | Jan 2 | Jan 6 | S | 5,125 | $78.57 | Sale −$402,671 | 30,453 | Yes | Form 4 |
| Swayze EricEVP Research | Jan 2 | Jan 6 | M | 18,338 | $60.89 | $1,116,601 | 48,791 | Yes | Form 4 |
| Swayze EricEVP Research | Jan 2 | Jan 6 | S | 18,338 | $79.27 | Sale −$1,453,653 | 30,453 | Yes | Form 4 |
| Swayze EricEVP Research | Jan 2 | Jan 6 | M · derivative | 5,125 | $60.89 | $312,061 | 22,403 | Yes | Form 4 |
| Swayze EricEVP Research | Jan 2 | Jan 6 | M · derivative | 18,338 | $60.89 | $1,116,601 | 4,065 | Yes | Form 4 |
| Swayze EricEVP Research | Jan 2 | Jan 6 | A · derivative | 19,350 | $79.67 | $1,541,615 | 19,350 | Yes | Form 4 |
| Swayze EricEVP Research | Jan 2 | Jan 6 | A · derivative | 150 | $79.67 | $11,951 | 150 | Yes | Form 4 |
| Jenne KyleEVP, Chf GL Pdt Str Ofcr | Jan 2 | Jan 6 | A · derivative | 19,350 | $79.67 | $1,541,615 | 19,350 | No | Form 4 |
| Wender Joseph H | Dec 1, 2025 | Dec 3, 2025 | S | 20,571 | $80.67 | Sale −$1,659,463 | 43,464 | Yes | Form 4 |
| Wender Joseph H | Dec 1, 2025 | Dec 3, 2025 | S | 7,429 | $81.23 | Sale −$603,458 | 36,035 | Yes | Form 4 |
| Devers Shannon L.EVP, Chief Human Resources Ofc | Nov 25, 2025 | Nov 28, 2025 | M | 16,777 | $53.77 | $902,099 | 34,271 | Yes | Form 4 |
| Devers Shannon L.EVP, Chief Human Resources Ofc | Nov 25, 2025 | Nov 28, 2025 | S | 16,777 | $80.91 | Sale −$1,357,427 | 17,494 | Yes | Form 4 |
| Devers Shannon L.EVP, Chief Human Resources Ofc | Nov 25, 2025 | Nov 28, 2025 | M · derivative | 16,777 | $53.77 | $902,099 | not reported | Yes | Form 4 |
| Klein Joseph III | Nov 25, 2025 | Nov 28, 2025 | M | 4,000 | $0.00 | $0 | 4,000 | Yes | Form 4 |
| Klein Joseph III | Nov 25, 2025 | Nov 28, 2025 | S | 4,000 | $80.00 | Sale −$320,000 | not reported | Yes | Form 4 |
| Klein Joseph III | Nov 25, 2025 | Nov 28, 2025 | M | 4,000 | $0.00 | $0 | 4,000 | Yes | Form 4 |
| Klein Joseph III | Nov 25, 2025 | Nov 28, 2025 | S | 4,000 | $80.00 | Sale −$320,000 | not reported | Yes | Form 4 |
| Klein Joseph III | Nov 25, 2025 | Nov 28, 2025 | M | 4,000 | $0.00 | $0 | 4,000 | Yes | Form 4 |
| Klein Joseph III | Nov 25, 2025 | Nov 28, 2025 | S | 4,000 | $80.00 | Sale −$320,000 | not reported | Yes | Form 4 |
| Klein Joseph III | Nov 25, 2025 | Nov 28, 2025 | M · derivative | 4,000 | $60.20 | $240,800 | 8,000 | Yes | Form 4 |
| Klein Joseph III | Nov 25, 2025 | Nov 28, 2025 | M · derivative | 4,000 | $60.20 | $240,800 | 4,000 | Yes | Form 4 |
| Klein Joseph III | Nov 25, 2025 | Nov 28, 2025 | M · derivative | 4,000 | $60.20 | $240,800 | not reported | Yes | Form 4 |
| Herman Joan E | Nov 19, 2025 | Nov 20, 2025 | M | 12,000 | $40.05 | $480,600 | 58,086 | No | Form 4 |
| Herman Joan E | Nov 19, 2025 | Nov 20, 2025 | S | 12,000 | $72.13 | Sale −$865,560 | 46,086 | No | Form 4 |
| Herman Joan E | Nov 19, 2025 | Nov 20, 2025 | M | 32,000 | $63.90 | $2,044,800 | 78,086 | No | Form 4 |
| Herman Joan E | Nov 19, 2025 | Nov 20, 2025 | S | 32,000 | $72.13 | Sale −$2,308,160 | 46,086 | No | Form 4 |
| Herman Joan E | Nov 19, 2025 | Nov 20, 2025 | M · derivative | 12,000 | $40.05 | $480,600 | not reported | No | Form 4 |
| Herman Joan E | Nov 19, 2025 | Nov 20, 2025 | M · derivative | 32,000 | $63.90 | $2,044,800 | not reported | No | Form 4 |
| Wender Joseph H | Nov 18, 2025 | Nov 20, 2025 | M | 16,000 | $24.42 | $390,720 | 16,000 | No | Form 4 |
| Wender Joseph H | Nov 18, 2025 | Nov 20, 2025 | M · derivative | 16,000 | $24.42 | $390,720 | not reported | No | Form 4 |
| Geary Richard SEVP, Chief Development Officer | Nov 6, 2025 | Nov 7, 2025 | M | 14,738 | $56.78 | $836,824 | 74,395 | Yes | Form 4 |
| Geary Richard SEVP, Chief Development Officer | Nov 6, 2025 | Nov 7, 2025 | S | 14,738 | $76.10 | Sale −$1,121,562 | 59,657 | Yes | Form 4 |
| Geary Richard SEVP, Chief Development Officer | Nov 6, 2025 | Nov 7, 2025 | M | 18,300 | $60.89 | $1,114,287 | 77,957 | Yes | Form 4 |
| Geary Richard SEVP, Chief Development Officer | Nov 6, 2025 | Nov 7, 2025 | S | 18,300 | $75.42 | Sale −$1,380,186 | 59,657 | Yes | Form 4 |
| Geary Richard SEVP, Chief Development Officer | Nov 6, 2025 | Nov 7, 2025 | M · derivative | 14,738 | $56.78 | $836,824 | not reported | Yes | Form 4 |
| Geary Richard SEVP, Chief Development Officer | Nov 6, 2025 | Nov 7, 2025 | M · derivative | 18,300 | $60.89 | $1,114,287 | not reported | Yes | Form 4 |
| Birchler BrianEVP, Corp and Development Ops | Nov 6, 2025 | Nov 7, 2025 | S | 8,000 | $76.17 | Sale −$609,360 | 48,826 | Yes | Form 4 |
| Geary Richard SEVP, Chief Development Officer | Nov 5, 2025 | Nov 7, 2025 | M | 800 | $56.78 | $45,424 | 60,457 | Yes | Form 4 |
| Geary Richard SEVP, Chief Development Officer | Nov 5, 2025 | Nov 7, 2025 | S | 800 | $75.01 | Sale −$60,008 | 59,657 | Yes | Form 4 |
| Geary Richard SEVP, Chief Development Officer | Nov 5, 2025 | Nov 7, 2025 | M | 801 | $60.89 | $48,773 | 60,458 | Yes | Form 4 |
| Geary Richard SEVP, Chief Development Officer | Nov 5, 2025 | Nov 7, 2025 | S | 801 | $75.01 | Sale −$60,083 | 59,657 | Yes | Form 4 |
| Geary Richard SEVP, Chief Development Officer | Nov 5, 2025 | Nov 7, 2025 | M · derivative | 800 | $56.78 | $45,424 | 14,738 | Yes | Form 4 |
| Geary Richard SEVP, Chief Development Officer | Nov 5, 2025 | Nov 7, 2025 | M · derivative | 801 | $60.89 | $48,773 | 18,300 | Yes | Form 4 |
| Geary Richard SEVP, Chief Development Officer | Nov 3, 2025 | Nov 7, 20254/A | M | 775 | $60.89 | $47,190 | 60,432 | Yes | Form 4/A |
| Geary Richard SEVP, Chief Development Officer | Nov 3, 2025 | Nov 7, 20254/A | S | 775 | $75.05 | Sale −$58,164 | 59,657 | Yes | Form 4/A |
| Geary Richard SEVP, Chief Development Officer | Nov 3, 2025 | Nov 7, 20254/A | M | 905 | $56.78 | $51,386 | 60,562 | Yes | Form 4/A |
| Geary Richard SEVP, Chief Development Officer | Nov 3, 2025 | Nov 7, 20254/A | S | 905 | $75.05 | Sale −$67,920 | 59,657 | Yes | Form 4/A |
| Geary Richard SEVP, Chief Development Officer | Nov 3, 2025 | Nov 7, 20254/A | M · derivative | 905 | $56.78 | $51,386 | 15,538 | Yes | Form 4/A |
| Geary Richard SEVP, Chief Development Officer | Nov 3, 2025 | Nov 7, 20254/A | M · derivative | 775 | $60.89 | $47,190 | 19,101 | Yes | Form 4/A |
| Geary Richard SEVP, Chief Development Officer | Nov 3, 2025 | Nov 3, 2025 | M | 775 | $56.78 | $44,005 | 60,432 | Yes | Form 4 |
| Geary Richard SEVP, Chief Development Officer | Nov 3, 2025 | Nov 3, 2025 | S | 775 | $75.05 | Sale −$58,164 | 59,657 | Yes | Form 4 |
| Geary Richard SEVP, Chief Development Officer | Nov 3, 2025 | Nov 3, 2025 | M | 905 | $60.89 | $55,105 | 60,562 | Yes | Form 4 |
| Geary Richard SEVP, Chief Development Officer | Nov 3, 2025 | Nov 3, 2025 | S | 905 | $75.05 | Sale −$67,920 | 59,657 | Yes | Form 4 |
| Geary Richard SEVP, Chief Development Officer | Nov 3, 2025 | Nov 3, 2025 | M · derivative | 775 | $56.78 | $44,005 | 15,668 | Yes | Form 4 |
| Geary Richard SEVP, Chief Development Officer | Nov 3, 2025 | Nov 3, 2025 | M · derivative | 905 | $60.89 | $55,105 | 18,971 | Yes | Form 4 |
| Geary Richard SEVP, Chief Development Officer | Oct 31, 2025 | Nov 3, 2025 | M | 34,585 | $60.89 | $2,105,881 | 114,242 | Yes | Form 4 |
| Geary Richard SEVP, Chief Development Officer | Oct 31, 2025 | Nov 3, 2025 | S | 34,585 | $75.11 | Sale −$2,597,679 | 79,657 | Yes | Form 4 |
| Geary Richard SEVP, Chief Development Officer | Oct 31, 2025 | Nov 3, 2025 | M | 34,664 | $56.78 | $1,968,222 | 114,321 | Yes | Form 4 |
| Geary Richard SEVP, Chief Development Officer | Oct 31, 2025 | Nov 3, 2025 | S | 34,664 | $75.11 | Sale −$2,603,613 | 79,657 | Yes | Form 4 |
| Geary Richard SEVP, Chief Development Officer | Oct 31, 2025 | Nov 3, 2025 | S | 20,000 | $75.11 | Sale −$1,502,200 | 59,657 | Yes | Form 4 |
| Geary Richard SEVP, Chief Development Officer | Oct 31, 2025 | Nov 3, 2025 | M · derivative | 34,664 | $56.78 | $1,968,222 | 16,443 | Yes | Form 4 |
| Geary Richard SEVP, Chief Development Officer | Oct 31, 2025 | Nov 3, 2025 | M · derivative | 34,585 | $60.89 | $2,105,881 | 19,876 | Yes | Form 4 |
| Loscalzo Joseph | Oct 31, 2025 | Nov 3, 2025 | M | 16,000 | $52.22 | $835,520 | 52,330 | Yes | Form 4 |
| Loscalzo Joseph | Oct 31, 2025 | Nov 3, 2025 | S | 16,000 | $75.10 | Sale −$1,201,600 | 36,330 | Yes | Form 4 |
| Loscalzo Joseph | Oct 31, 2025 | Nov 3, 2025 | M · derivative | 16,000 | $52.22 | $835,520 | not reported | Yes | Form 4 |
| Wender Joseph H | Oct 31, 2025 | Nov 3, 2025 | S | 11,200 | $75.16 | Sale −$841,792 | 64,035 | Yes | Form 4 |
| Wender Joseph H | Oct 30, 2025 | Nov 3, 2025 | S | 2,484 | $72.19 | Sale −$179,320 | 89,551 | Yes | Form 4 |
| Wender Joseph H | Oct 30, 2025 | Nov 3, 2025 | S | 8,341 | $73.16 | Sale −$610,228 | 81,210 | Yes | Form 4 |
| Wender Joseph H | Oct 30, 2025 | Nov 3, 2025 | S | 5,975 | $73.85 | Sale −$441,254 | 75,235 | Yes | Form 4 |
| Devers Shannon L.EVP, Chief Human Resources Ofc | Oct 16, 2025 | Oct 16, 2025 | S | 1,263 | $73.62 | Sale −$92,982 | 17,494 | Yes | Form 4 |
| Swayze EricEVP Research | Oct 16, 2025 | Oct 16, 2025 | S | 53 | $73.62 | Sale −$3,902 | 256 | No | Form 4 |
| Birchler BrianEVP, Corp and Development Ops | Oct 15, 2025 | Oct 16, 2025 | M | 12,425 | $53.77 | $668,092 | 69,251 | Yes | Form 4 |
| Birchler BrianEVP, Corp and Development Ops | Oct 15, 2025 | Oct 16, 2025 | S | 12,425 | $72.23 | Sale −$897,458 | 56,826 | Yes | Form 4 |
| Birchler BrianEVP, Corp and Development Ops | Oct 15, 2025 | Oct 16, 2025 | M · derivative | 12,425 | $53.77 | $668,092 | not reported | Yes | Form 4 |
| Devers Shannon L.EVP, Chief Human Resources Ofc | Oct 15, 2025 | Oct 16, 2025 | M | 6,000 | $48.51 | $291,060 | 21,937 | Yes | Form 4 |
| Devers Shannon L.EVP, Chief Human Resources Ofc | Oct 15, 2025 | Oct 16, 2025 | S | 6,000 | $72.94 | Sale −$437,640 | 15,937 | Yes | Form 4 |
| Devers Shannon L.EVP, Chief Human Resources Ofc | Oct 15, 2025 | Oct 16, 2025 | M | 2,820 | $0.00 | $0 | 18,757 | Yes | Form 4 |
| Devers Shannon L.EVP, Chief Human Resources Ofc | Oct 15, 2025 | Oct 16, 2025 | M · derivative | 6,000 | $48.51 | $291,060 | not reported | Yes | Form 4 |
| Devers Shannon L.EVP, Chief Human Resources Ofc | Oct 15, 2025 | Oct 16, 2025 | M · derivative | 2,820 | $0.00 | $0 | 60,406 | Yes | Form 4 |
| Parshall B Lynne | Oct 15, 2025 | Oct 16, 2025 | S | 5,000 | $71.74 | Sale −$358,700 | 61,344 | Yes | Form 4 |
| Swayze EricEVP Research | Oct 15, 2025 | Oct 16, 2025 | M | 125 | $0.00 | $0 | 309 | No | Form 4 |
| Swayze EricEVP Research | Oct 15, 2025 | Oct 16, 2025 | M · derivative | 125 | $0.00 | $0 | 497 | No | Form 4 |
| Birchler BrianEVP, Corp and Development Ops | Oct 14, 2025 | Oct 16, 2025 | M | 11,475 | $53.77 | $617,011 | 68,301 | Yes | Form 4 |
| Birchler BrianEVP, Corp and Development Ops | Oct 14, 2025 | Oct 16, 2025 | S | 11,475 | $72.03 | Sale −$826,544 | 56,826 | Yes | Form 4 |
| Birchler BrianEVP, Corp and Development Ops | Oct 14, 2025 | Oct 16, 2025 | M · derivative | 11,475 | $53.77 | $617,011 | 12,425 | Yes | Form 4 |
| Baroldi JosephEVP, Chief Business Officer | Oct 6, 2025 | Oct 8, 2025 | S | 1,625 | $69.37 | Sale −$112,726 | 30,301 | Yes | Form 4 |
| Monia Brett PChief Executive Officer | Oct 6, 2025 | Oct 8, 2025 | S | 437 | $69.26 | Sale −$30,267 | 179,572 | Yes | Form 4 |
| O'Neil Patrick R.EVP CLO & General Counsel | Oct 6, 2025 | Oct 8, 2025 | M | 10,200 | $52.87 | $539,274 | 67,330 | Yes | Form 4 |
| O'Neil Patrick R.EVP CLO & General Counsel | Oct 6, 2025 | Oct 8, 2025 | S | 10,200 | $69.89 | Sale −$712,878 | 57,130 | Yes | Form 4 |
| O'Neil Patrick R.EVP CLO & General Counsel | Oct 6, 2025 | Oct 8, 2025 | S | 3,241 | $69.27 | Sale −$224,504 | 53,889 | Yes | Form 4 |
| O'Neil Patrick R.EVP CLO & General Counsel | Oct 6, 2025 | Oct 8, 2025 | M · derivative | 10,200 | $52.87 | $539,274 | 17,000 | Yes | Form 4 |
| Swayze EricEVP Research | Oct 6, 2025 | Oct 8, 2025 | S | 6,849 | $69.02 | Sale −$472,718 | 30,453 | Yes | Form 4 |
| Baroldi JosephEVP, Chief Business Officer | Oct 2, 2025 | Oct 2, 2025 | M | 15,000 | $31.80 | $477,000 | 46,926 | Yes | Form 4 |
| Baroldi JosephEVP, Chief Business Officer | Oct 2, 2025 | Oct 2, 2025 | S | 15,000 | $68.01 | Sale −$1,020,150 | 31,926 | Yes | Form 4 |
| Baroldi JosephEVP, Chief Business Officer | Oct 2, 2025 | Oct 2, 2025 | M · derivative | 15,000 | $31.80 | $477,000 | 26,700 | Yes | Form 4 |
| O'Neil Patrick R.EVP CLO & General Counsel | Oct 2, 2025 | Oct 2, 2025 | M | 30,203 | $56.78 | $1,714,926 | 87,333 | Yes | Form 4 |
| O'Neil Patrick R.EVP CLO & General Counsel | Oct 2, 2025 | Oct 2, 2025 | S | 30,203 | $67.69 | Sale −$2,044,441 | 57,130 | Yes | Form 4 |
| O'Neil Patrick R.EVP CLO & General Counsel | Oct 2, 2025 | Oct 2, 2025 | M | 34,461 | $60.89 | $2,098,330 | 91,591 | Yes | Form 4 |
| O'Neil Patrick R.EVP CLO & General Counsel | Oct 2, 2025 | Oct 2, 2025 | S | 34,461 | $67.69 | Sale −$2,332,665 | 57,130 | Yes | Form 4 |
| O'Neil Patrick R.EVP CLO & General Counsel | Oct 2, 2025 | Oct 2, 2025 | M · derivative | 30,203 | $56.78 | $1,714,926 | not reported | Yes | Form 4 |
| O'Neil Patrick R.EVP CLO & General Counsel | Oct 2, 2025 | Oct 2, 2025 | M · derivative | 34,461 | $60.89 | $2,098,330 | not reported | Yes | Form 4 |
| Swayze EricEVP Research | Oct 2, 2025 | Oct 2, 2025 | M | 12,972 | $53.77 | $697,504 | 50,274 | Yes | Form 4 |
| Swayze EricEVP Research | Oct 2, 2025 | Oct 2, 2025 | S | 12,972 | $66.23 | Sale −$859,136 | 37,302 | Yes | Form 4 |
| Swayze EricEVP Research | Oct 2, 2025 | Oct 2, 2025 | M · derivative | 12,972 | $53.77 | $697,504 | not reported | Yes | Form 4 |
| Swayze EricEVP Research | Oct 1, 2025 | Oct 2, 2025 | M | 14,142 | $53.77 | $760,415 | 51,444 | Yes | Form 4 |
| Swayze EricEVP Research | Oct 1, 2025 | Oct 2, 2025 | S | 14,142 | $66.09 | Sale −$934,645 | 37,302 | Yes | Form 4 |
| Swayze EricEVP Research | Oct 1, 2025 | Oct 2, 2025 | M · derivative | 14,142 | $53.77 | $760,415 | 12,972 | Yes | Form 4 |
| Wender Joseph H | Oct 1, 2025 | Oct 2, 2025 | S | 16,800 | $65.50 | Sale −$1,100,400 | 92,035 | Yes | Form 4 |
| Hougen Elizabeth LEVP, Finance & CFO | Sep 30, 2025 | Oct 1, 2025 | M | 49,800 | $53.77 | $2,677,746 | 160,300 | Yes | Form 4 |
| Hougen Elizabeth LEVP, Finance & CFO | Sep 30, 2025 | Oct 1, 2025 | S | 49,800 | $65.26 | Sale −$3,249,948 | 110,500 | Yes | Form 4 |
| Hougen Elizabeth LEVP, Finance & CFO | Sep 30, 2025 | Oct 1, 2025 | M · derivative | 49,800 | $53.77 | $2,677,746 | not reported | Yes | Form 4 |
| Geary Richard SEVP, Chief Development Officer | Sep 30, 2025 | Oct 1, 2025 | M | 57,900 | $53.77 | $3,113,283 | 137,557 | Yes | Form 4 |
| Geary Richard SEVP, Chief Development Officer | Sep 30, 2025 | Oct 1, 2025 | S | 57,900 | $65.24 | Sale −$3,777,396 | 79,657 | Yes | Form 4 |
| Geary Richard SEVP, Chief Development Officer | Sep 30, 2025 | Oct 1, 2025 | M · derivative | 57,900 | $53.77 | $3,113,283 | not reported | Yes | Form 4 |
| O'Neil Patrick R.EVP CLO & General Counsel | Sep 30, 2025 | Oct 1, 2025 | M | 14,827 | $56.78 | $841,877 | 71,957 | Yes | Form 4 |
| O'Neil Patrick R.EVP CLO & General Counsel | Sep 30, 2025 | Oct 1, 2025 | S | 14,827 | $64.68 | Sale −$959,010 | 57,130 | Yes | Form 4 |
| O'Neil Patrick R.EVP CLO & General Counsel | Sep 30, 2025 | Oct 1, 2025 | M · derivative | 14,827 | $56.78 | $841,877 | 30,203 | Yes | Form 4 |
| O'Neil Patrick R.EVP CLO & General Counsel | Sep 29, 2025 | Oct 1, 2025 | M | 10,473 | $56.78 | $594,657 | 67,603 | Yes | Form 4 |
| O'Neil Patrick R.EVP CLO & General Counsel | Sep 29, 2025 | Oct 1, 2025 | S | 10,473 | $64.54 | Sale −$675,927 | 57,130 | Yes | Form 4 |
| O'Neil Patrick R.EVP CLO & General Counsel | Sep 29, 2025 | Oct 1, 2025 | M · derivative | 10,473 | $56.78 | $594,657 | 45,030 | Yes | Form 4 |
| O'Neil Patrick R.EVP CLO & General Counsel | Sep 12, 2025 | Sep 16, 2025 | M | 1,700 | $56.78 | $96,526 | 58,830 | Yes | Form 4 |
| O'Neil Patrick R.EVP CLO & General Counsel | Sep 12, 2025 | Sep 16, 2025 | S | 1,700 | $64.58 | Sale −$109,786 | 57,130 | Yes | Form 4 |
| O'Neil Patrick R.EVP CLO & General Counsel | Sep 12, 2025 | Sep 16, 2025 | M · derivative | 1,700 | $56.78 | $96,526 | 55,503 | Yes | Form 4 |
| O'Neil Patrick R.EVP CLO & General Counsel | Sep 9, 2025 | Sep 11, 2025 | M | 20,000 | $60.89 | $1,217,800 | 77,130 | Yes | Form 4 |
| O'Neil Patrick R.EVP CLO & General Counsel | Sep 9, 2025 | Sep 11, 2025 | S | 20,000 | $64.56 | Sale −$1,291,200 | 57,130 | Yes | Form 4 |
| O'Neil Patrick R.EVP CLO & General Counsel | Sep 9, 2025 | Sep 11, 2025 | M | 1,000 | $56.78 | $56,780 | 58,130 | Yes | Form 4 |
| O'Neil Patrick R.EVP CLO & General Counsel | Sep 9, 2025 | Sep 11, 2025 | S | 1,000 | $64.56 | Sale −$64,560 | 57,130 | Yes | Form 4 |
| O'Neil Patrick R.EVP CLO & General Counsel | Sep 9, 2025 | Sep 11, 2025 | M · derivative | 1,000 | $56.78 | $56,780 | 57,203 | Yes | Form 4 |
| O'Neil Patrick R.EVP CLO & General Counsel | Sep 9, 2025 | Sep 11, 2025 | M · derivative | 20,000 | $60.89 | $1,217,800 | 34,461 | Yes | Form 4 |
| Baroldi JosephEVP, Chief Business Officer | Sep 9, 2025 | Sep 11, 2025 | M | 11,950 | $31.80 | $380,010 | 43,876 | Yes | Form 4 |
| Baroldi JosephEVP, Chief Business Officer | Sep 9, 2025 | Sep 11, 2025 | S | 11,950 | $62.16 | Sale −$742,812 | 31,926 | Yes | Form 4 |
| Baroldi JosephEVP, Chief Business Officer | Sep 9, 2025 | Sep 11, 2025 | M · derivative | 11,950 | $31.80 | $380,010 | 41,700 | Yes | Form 4 |
| Bennett C FrankEVP, Chief Scientific Officer | Sep 5, 2025 | Sep 9, 2025 | S | 6,000 | $59.60 | Sale −$357,600 | 82,679 | Yes | Form 4 |
| Baroldi JosephEVP, Chief Business Officer | Sep 5, 2025 | Sep 9, 2025 | M | 250 | $31.80 | $7,950 | 32,176 | Yes | Form 4 |
| Baroldi JosephEVP, Chief Business Officer | Sep 5, 2025 | Sep 9, 2025 | S | 250 | $62.00 | Sale −$15,500 | 31,926 | Yes | Form 4 |
| Baroldi JosephEVP, Chief Business Officer | Sep 5, 2025 | Sep 9, 2025 | M · derivative | 250 | $31.80 | $7,950 | 53,650 | Yes | Form 4 |
| Schneider EugeneEVP, Chf Clinical Develop Ofcr | Sep 3, 2025 | Sep 4, 2025 | M | 19,658 | $53.77 | $1,057,011 | 71,165 | Yes | Form 4 |
| Schneider EugeneEVP, Chf Clinical Develop Ofcr | Sep 3, 2025 | Sep 4, 2025 | S | 12,455 | $60.46 | Sale −$753,029 | 58,710 | Yes | Form 4 |
| Schneider EugeneEVP, Chf Clinical Develop Ofcr | Sep 3, 2025 | Sep 4, 2025 | S | 7,203 | $61.42 | Sale −$442,408 | 51,507 | Yes | Form 4 |
| Schneider EugeneEVP, Chf Clinical Develop Ofcr | Sep 3, 2025 | Sep 4, 2025 | M · derivative | 19,658 | $53.77 | $1,057,011 | not reported | Yes | Form 4 |
| Loscalzo Joseph | Sep 3, 2025 | Sep 4, 2025 | M | 16,000 | $24.42 | $390,720 | 52,330 | No | Form 4 |
| Loscalzo Joseph | Sep 3, 2025 | Sep 4, 2025 | S | 16,000 | $60.15 | Sale −$962,400 | 36,330 | No | Form 4 |
| Loscalzo Joseph | Sep 3, 2025 | Sep 4, 2025 | M · derivative | 16,000 | $24.42 | $390,720 | not reported | No | Form 4 |
| Bennett C FrankEVP, Chief Scientific Officer | Sep 3, 2025 | Sep 4, 2025 | M | 46,800 | $53.77 | $2,516,436 | 135,479 | Yes | Form 4 |
| Bennett C FrankEVP, Chief Scientific Officer | Sep 3, 2025 | Sep 4, 2025 | S | 33,909 | $60.62 | Sale −$2,055,564 | 101,570 | Yes | Form 4 |
| Bennett C FrankEVP, Chief Scientific Officer | Sep 3, 2025 | Sep 4, 2025 | M | 12,891 | $61.50 | $792,797 | 88,679 | Yes | Form 4 |
| Bennett C FrankEVP, Chief Scientific Officer | Sep 3, 2025 | Sep 4, 2025 | M · derivative | 46,800 | $53.77 | $2,516,436 | not reported | Yes | Form 4 |
| O'Neil Patrick R.EVP CLO & General Counsel | Sep 3, 2025 | Sep 4, 2025 | M | 14,000 | $37.58 | $526,120 | 71,130 | Yes | Form 4 |
| O'Neil Patrick R.EVP CLO & General Counsel | Sep 3, 2025 | Sep 4, 2025 | S | 65,475 | $60.89 | Sale −$3,986,773 | 5,655 | Yes | Form 4 |
| O'Neil Patrick R.EVP CLO & General Counsel | Sep 3, 2025 | Sep 4, 2025 | M | 13,050 | $32.60 | $425,430 | 18,705 | Yes | Form 4 |
| O'Neil Patrick R.EVP CLO & General Counsel | Sep 3, 2025 | Sep 4, 2025 | S | 11,375 | $61.42 | Sale −$698,653 | 7,330 | Yes | Form 4 |
| O'Neil Patrick R.EVP CLO & General Counsel | Sep 3, 2025 | Sep 4, 2025 | M | 49,800 | $53.77 | $2,677,746 | 57,130 | Yes | Form 4 |
| O'Neil Patrick R.EVP CLO & General Counsel | Sep 3, 2025 | Sep 4, 2025 | M · derivative | 13,050 | $32.60 | $425,430 | 4,467 | Yes | Form 4 |
| O'Neil Patrick R.EVP CLO & General Counsel | Sep 3, 2025 | Sep 4, 2025 | M · derivative | 14,000 | $37.58 | $526,120 | 8,942 | Yes | Form 4 |
| O'Neil Patrick R.EVP CLO & General Counsel | Sep 3, 2025 | Sep 4, 2025 | M · derivative | 49,800 | $53.77 | $2,677,746 | not reported | Yes | Form 4 |
| Baroldi JosephEVP, Chief Business Officer | Sep 3, 2025 | Sep 4, 2025 | M | 2,800 | $31.80 | $89,040 | 34,726 | Yes | Form 4 |
| Baroldi JosephEVP, Chief Business Officer | Sep 3, 2025 | Sep 4, 2025 | S | 2,800 | $62.01 | Sale −$173,628 | 31,926 | Yes | Form 4 |
| Baroldi JosephEVP, Chief Business Officer | Sep 3, 2025 | Sep 4, 2025 | M | 15,000 | $31.80 | $477,000 | 46,926 | Yes | Form 4 |
| Baroldi JosephEVP, Chief Business Officer | Sep 3, 2025 | Sep 4, 2025 | S | 30,000 | $59.09 | Sale −$1,772,700 | 16,926 | Yes | Form 4 |
| Baroldi JosephEVP, Chief Business Officer | Sep 3, 2025 | Sep 4, 2025 | M | 15,000 | $31.80 | $477,000 | 31,926 | Yes | Form 4 |
| Baroldi JosephEVP, Chief Business Officer | Sep 3, 2025 | Sep 4, 2025 | M · derivative | 2,800 | $31.80 | $89,040 | 83,900 | Yes | Form 4 |
| Baroldi JosephEVP, Chief Business Officer | Sep 3, 2025 | Sep 4, 2025 | M · derivative | 15,000 | $31.80 | $477,000 | 68,900 | Yes | Form 4 |
| Baroldi JosephEVP, Chief Business Officer | Sep 3, 2025 | Sep 4, 2025 | M · derivative | 15,000 | $31.80 | $477,000 | 53,900 | Yes | Form 4 |
| Wender Joseph H | Sep 3, 2025 | Sep 4, 2025 | S | 11,200 | $60.14 | Sale −$673,568 | 108,835 | Yes | Form 4 |
| Devers Shannon L.EVP, Chief Human Resources Ofc | Sep 3, 2025 | Sep 4, 2025 | M | 2,234 | $37.58 | $83,954 | 18,171 | Yes | Form 4 |
| Devers Shannon L.EVP, Chief Human Resources Ofc | Sep 3, 2025 | Sep 4, 2025 | S | 3,162 | $61.02 | Sale −$192,945 | 15,009 | Yes | Form 4 |
| Devers Shannon L.EVP, Chief Human Resources Ofc | Sep 3, 2025 | Sep 4, 2025 | M | 928 | $32.60 | $30,253 | 15,937 | Yes | Form 4 |
| Devers Shannon L.EVP, Chief Human Resources Ofc | Sep 3, 2025 | Sep 4, 2025 | M · derivative | 928 | $32.60 | $30,253 | 13,440 | Yes | Form 4 |
| Devers Shannon L.EVP, Chief Human Resources Ofc | Sep 3, 2025 | Sep 4, 2025 | M · derivative | 2,234 | $37.58 | $83,954 | 13,083 | Yes | Form 4 |
| Klein Joseph III | Sep 3, 2025 | Sep 4, 2025 | M | 16,000 | $0.00 | $0 | 16,000 | Yes | Form 4 |
| Klein Joseph III | Sep 3, 2025 | Sep 4, 2025 | M | 12,000 | $0.00 | $0 | 28,000 | Yes | Form 4 |
| Klein Joseph III | Sep 3, 2025 | Sep 4, 2025 | S | 28,000 | $60.00 | Sale −$1,680,000 | not reported | Yes | Form 4 |
| Klein Joseph III | Sep 3, 2025 | Sep 4, 2025 | M · derivative | 12,000 | $42.88 | $514,560 | not reported | Yes | Form 4 |