IRONDisc Medicine, Inc.
- Market cap
- $3.31B
- as of 2026-10-23
- Latest close
- $74.51
- as of 2026-10-23
- Sector
- Healthcare
- as of 2026-10-24
- Industry
- Biotechnology
- as of 2026-10-24
Cluster
No cluster in the last 90 days under the default rule (14d · ≥2 insiders · all roles).
Form 4 historysince 2023-11-07
Showing the latest 500 of 550 transactions.
| Insider | Traded | Filed | Type | Shares | Price | Value | Owned after | 10b5-1 plan | Filing |
|---|---|---|---|---|---|---|---|---|---|
| Bitterman Kevin | Oct 21 | Oct 21 | S | 13,783 | $80.23 | Sale −$1,105,810 | 296,277 | Yes | Form 4 |
| Bitterman Kevin | Oct 21 | Oct 21 | S | 11,470 | $80.23 | Sale −$920,238 | 293,430 | Yes | Form 4 |
| Bitterman Kevin | Oct 21 | Oct 21 | S | 266 | $80.23 | Sale −$21,341 | 12,991 | Yes | Form 4 |
| Bitterman Kevin | Oct 20 | Oct 21 | S | 2,869 | $79.95 | Sale −$229,377 | 310,060 | Yes | Form 4 |
| Bitterman Kevin | Oct 20 | Oct 21 | S | 2,388 | $79.95 | Sale −$190,921 | 304,900 | Yes | Form 4 |
| Bitterman Kevin | Oct 20 | Oct 21 | S | 55 | $79.95 | Sale −$4,397 | 13,257 | Yes | Form 4 |
| Bitterman Kevin | Oct 19 | Oct 21 | S | 5,937 | $79.97 | Sale −$474,782 | 312,929 | Yes | Form 4 |
| Bitterman Kevin | Oct 19 | Oct 21 | S | 4,942 | $79.97 | Sale −$395,212 | 307,288 | Yes | Form 4 |
| Bitterman Kevin | Oct 19 | Oct 21 | S | 115 | $79.97 | Sale −$9,197 | 13,312 | Yes | Form 4 |
| Quisel John DChief Executive Officer | Sep 15 | Sep 16 | M | 36,000 | $1.01 | $36,360 | 262,064 | No | Form 4 |
| Quisel John DChief Executive Officer | Sep 15 | Sep 16 | M · derivative | 36,000 | $1.01 | $36,360 | 150,120 | No | Form 4 |
| Bitterman Kevin | Sep 11 | Sep 15 | M | 7,136 | $45.69 | $326,044 | 7,136 | No | Form 4 |
| Bitterman Kevin | Sep 11 | Sep 15 | M | 10,000 | $38.85 | $388,500 | 17,136 | No | Form 4 |
| Bitterman Kevin | Sep 11 | Sep 15 | M | 10,000 | $50.86 | $508,600 | 27,136 | No | Form 4 |
| Bitterman Kevin | Sep 11 | Sep 15 | S | 27,136 | $70.11 | Sale −$1,902,505 | not reported | No | Form 4 |
| Bitterman Kevin | Sep 11 | Sep 15 | M · derivative | 7,136 | $45.69 | $326,044 | not reported | No | Form 4 |
| Bitterman Kevin | Sep 11 | Sep 15 | M · derivative | 10,000 | $38.85 | $388,500 | not reported | No | Form 4 |
| Bitterman Kevin | Sep 11 | Sep 15 | M · derivative | 10,000 | $50.86 | $508,600 | not reported | No | Form 4 |
| Bitterman Kevin | Sep 4 | Sep 9 | S | 912 | $79.96 | Sale −$72,924 | 318,866 | Yes | Form 4 |
| Bitterman Kevin | Sep 4 | Sep 9 | S | 759 | $79.96 | Sale −$60,690 | 312,230 | Yes | Form 4 |
| Bitterman Kevin | Sep 4 | Sep 9 | S | 18 | $79.96 | Sale −$1,439 | 13,427 | Yes | Form 4 |
| Bitterman Kevin | Sep 3 | Sep 3 | S | 2,810 | $79.98 | Sale −$224,744 | 319,778 | Yes | Form 4 |
| Bitterman Kevin | Sep 3 | Sep 3 | S | 2,339 | $79.98 | Sale −$187,073 | 312,989 | Yes | Form 4 |
| Bitterman Kevin | Sep 3 | Sep 3 | S | 54 | $79.98 | Sale −$4,319 | 13,445 | Yes | Form 4 |
| Bitterman Kevin | Sep 2 | Sep 3 | S | 26,542 | $80.17 | Sale −$2,127,872 | 322,598 | Yes | Form 4 |
| Bitterman Kevin | Sep 2 | Sep 3 | S | 22,090 | $80.17 | Sale −$1,770,955 | 315,337 | Yes | Form 4 |
| Bitterman Kevin | Sep 2 | Sep 3 | S | 511 | $80.17 | Sale −$40,967 | 13,501 | Yes | Form 4 |
| Bitterman Kevin | Sep 2 | Sep 3 | S | 10 | $80.98 | Sale −$810 | 322,588 | Yes | Form 4 |
| Bitterman Kevin | Sep 2 | Sep 3 | S | 9 | $80.98 | Sale −$729 | 315,328 | Yes | Form 4 |
| Bitterman Kevin | Sep 2 | Sep 3 | S | 2 | $80.98 | Sale −$162 | 13,499 | Yes | Form 4 |
| Bitterman Kevin | Sep 1 | Sep 3 | S | 70 | $79.95 | Sale −$5,597 | 349,140 | Yes | Form 4 |
| Bitterman Kevin | Sep 1 | Sep 3 | S | 58 | $79.95 | Sale −$4,637 | 337,427 | Yes | Form 4 |
| Bitterman Kevin | Sep 1 | Sep 3 | S | 1 | $79.95 | Sale −$80 | 14,012 | Yes | Form 4 |
| Yu Jonathan Yen-WenChief Operating Officer | Aug 25 | Aug 26 | M | 8,796 | $13.50 | $118,746 | 63,120 | Yes | Form 4 |
| Yu Jonathan Yen-WenChief Operating Officer | Aug 25 | Aug 26 | S | 8,796 | $83.12 | Sale −$731,124 | 54,324 | Yes | Form 4 |
| Yu Jonathan Yen-WenChief Operating Officer | Aug 25 | Aug 26 | M · derivative | 8,796 | $13.50 | $118,746 | 13,847 | Yes | Form 4 |
| Yu Jonathan Yen-WenChief Operating Officer | Aug 24 | Aug 26 | M | 300 | $13.50 | $4,050 | 54,624 | Yes | Form 4 |
| Yu Jonathan Yen-WenChief Operating Officer | Aug 24 | Aug 26 | S | 300 | $82.53 | Sale −$24,759 | 54,324 | Yes | Form 4 |
| Yu Jonathan Yen-WenChief Operating Officer | Aug 24 | Aug 26 | M · derivative | 300 | $13.50 | $4,050 | 22,643 | Yes | Form 4 |
| Quisel John DChief Executive Officer | Aug 17 | Aug 18 | M | 33,000 | $13.50 | $445,500 | 259,064 | Yes | Form 4 |
| Quisel John DChief Executive Officer | Aug 17 | Aug 18 | S | 8,400 | $78.11 | Sale −$656,124 | 250,664 | Yes | Form 4 |
| Quisel John DChief Executive Officer | Aug 17 | Aug 18 | S | 12,712 | $79.20 | Sale −$1,006,790 | 237,952 | Yes | Form 4 |
| Quisel John DChief Executive Officer | Aug 17 | Aug 18 | S | 11,888 | $79.84 | Sale −$949,138 | 226,064 | Yes | Form 4 |
| Quisel John DChief Executive Officer | Aug 17 | Aug 18 | M · derivative | 33,000 | $13.50 | $445,500 | 91,586 | Yes | Form 4 |
| Yu Jonathan Yen-WenChief Operating Officer | Aug 12 | Aug 14 | M | 804 | $13.50 | $10,854 | 55,128 | Yes | Form 4 |
| Yu Jonathan Yen-WenChief Operating Officer | Aug 12 | Aug 14 | S | 804 | $82.64 | Sale −$66,443 | 54,324 | Yes | Form 4 |
| Yu Jonathan Yen-WenChief Operating Officer | Aug 12 | Aug 14 | M · derivative | 804 | $13.50 | $10,854 | 22,943 | Yes | Form 4 |
| Khara RahulChief Legal Officer | Aug 6 | Aug 7 | M | 5,000 | $14.69 | $73,450 | 57,324 | Yes | Form 4 |
| Khara RahulChief Legal Officer | Aug 6 | Aug 7 | S | 5,000 | $80.00 | Sale −$400,000 | 52,324 | Yes | Form 4 |
| Khara RahulChief Legal Officer | Aug 6 | Aug 7 | M · derivative | 5,000 | $14.69 | $73,450 | 49,804 | Yes | Form 4 |
| Quisel John DChief Executive Officer | Jul 13 | Jul 14 | M | 25,584 | $9.86 | $252,258 | 251,648 | Yes | Form 4 |
| Quisel John DChief Executive Officer | Jul 13 | Jul 14 | M | 7,416 | $13.50 | $100,116 | 259,064 | Yes | Form 4 |
| Quisel John DChief Executive Officer | Jul 13 | Jul 14 | S | 9,704 | $74.27 | Sale −$720,716 | 249,360 | Yes | Form 4 |
| Quisel John DChief Executive Officer | Jul 13 | Jul 14 | S | 16,896 | $74.95 | Sale −$1,266,355 | 232,464 | Yes | Form 4 |
| Quisel John DChief Executive Officer | Jul 13 | Jul 14 | S | 6,400 | $76.05 | Sale −$486,720 | 226,064 | Yes | Form 4 |
| Quisel John DChief Executive Officer | Jul 13 | Jul 14 | M · derivative | 25,584 | $9.86 | $252,258 | 15,791 | Yes | Form 4 |
| Quisel John DChief Executive Officer | Jul 13 | Jul 14 | M · derivative | 7,416 | $13.50 | $100,116 | 124,586 | Yes | Form 4 |
| Yu Jonathan Yen-WenChief Operating Officer | Jul 7 | Jul 9 | M | 100 | $13.50 | $1,350 | 54,424 | Yes | Form 4 |
| Yu Jonathan Yen-WenChief Operating Officer | Jul 7 | Jul 9 | S | 100 | $82.50 | Sale −$8,250 | 54,324 | Yes | Form 4 |
| Yu Jonathan Yen-WenChief Operating Officer | Jul 7 | Jul 9 | M · derivative | 100 | $13.50 | $1,350 | 23,747 | Yes | Form 4 |
| Khara RahulChief Legal Officer | Jun 29 | Jun 30 | M | 1,649 | $14.69 | $24,224 | 53,822 | Yes | Form 4 |
| Khara RahulChief Legal Officer | Jun 29 | Jun 30 | S | 1,649 | $75.00 | Sale −$123,675 | 52,173 | Yes | Form 4 |
| Khara RahulChief Legal Officer | Jun 29 | Jun 30 | M · derivative | 1,649 | $14.69 | $24,224 | 54,804 | Yes | Form 4 |
| Yu Jonathan Yen-WenChief Operating Officer | Jun 26 | Jun 30 | M | 300 | $13.50 | $4,050 | 54,624 | Yes | Form 4 |
| Yu Jonathan Yen-WenChief Operating Officer | Jun 26 | Jun 30 | S | 300 | $72.50 | Sale −$21,750 | 54,324 | Yes | Form 4 |
| Yu Jonathan Yen-WenChief Operating Officer | Jun 26 | Jun 30 | M · derivative | 300 | $13.50 | $4,050 | 23,847 | Yes | Form 4 |
| Khara RahulChief Legal Officer | Jun 26 | Jun 30 | M | 851 | $14.69 | $12,501 | 53,024 | Yes | Form 4 |
| Khara RahulChief Legal Officer | Jun 26 | Jun 30 | S | 851 | $75.00 | Sale −$63,825 | 52,173 | Yes | Form 4 |
| Khara RahulChief Legal Officer | Jun 26 | Jun 30 | M · derivative | 851 | $14.69 | $12,501 | 56,453 | Yes | Form 4 |
| Yu Jonathan Yen-WenChief Operating Officer | Jun 22 | Jun 24 | M | 9,700 | $13.50 | $130,950 | 64,024 | Yes | Form 4 |
| Yu Jonathan Yen-WenChief Operating Officer | Jun 22 | Jun 24 | S | 9,700 | $72.66 | Sale −$704,802 | 54,324 | Yes | Form 4 |
| Yu Jonathan Yen-WenChief Operating Officer | Jun 22 | Jun 24 | M · derivative | 9,700 | $13.50 | $130,950 | 24,147 | Yes | Form 4 |
| Ahmed Nadim | Jun 18 | Jun 23 | A · derivative | 5,176 | $70.79 | $366,409 | 5,176 | No | Form 4 |
| Bitterman Kevin | Jun 18 | Jun 23 | A · derivative | 6,212 | $70.79 | $439,747 | 6,212 | No | Form 4 |
| Chin Mark | Jun 18 | Jun 23 | A · derivative | 6,212 | $70.79 | $439,747 | 6,212 | No | Form 4 |
| Gemayel Georges | Jun 18 | Jun 23 | A · derivative | 6,212 | $70.79 | $439,747 | 6,212 | No | Form 4 |
| Nicholson Donald William | Jun 18 | Jun 23 | A · derivative | 6,212 | $70.79 | $439,747 | 6,212 | No | Form 4 |
| Ratcliffe Liam | Jun 18 | Jun 23 | A · derivative | 6,212 | $70.79 | $439,747 | 6,212 | No | Form 4 |
| White William Richard | Jun 18 | Jun 23 | A · derivative | 6,212 | $70.79 | $439,747 | 6,212 | No | Form 4 |
| Quisel John DChief Executive Officer | Jun 18 | Jun 23 | M | 34,000 | $9.86 | $335,240 | 260,064 | Yes | Form 4 |
| Quisel John DChief Executive Officer | Jun 18 | Jun 23 | S | 22,927 | $69.92 | Sale −$1,603,056 | 237,137 | Yes | Form 4 |
| Quisel John DChief Executive Officer | Jun 18 | Jun 23 | S | 9,522 | $70.70 | Sale −$673,205 | 227,615 | Yes | Form 4 |
| Quisel John DChief Executive Officer | Jun 18 | Jun 23 | S | 1,551 | $71.61 | Sale −$111,067 | 226,064 | Yes | Form 4 |
| Quisel John DChief Executive Officer | Jun 18 | Jun 23 | M · derivative | 34,000 | $9.86 | $335,240 | 41,375 | Yes | Form 4 |
| Khara RahulChief Legal Officer | Jun 18 | Jun 23 | M | 7,500 | $14.69 | $110,175 | 59,673 | Yes | Form 4 |
| Khara RahulChief Legal Officer | Jun 18 | Jun 23 | S | 5,400 | $69.94 | Sale −$377,676 | 54,273 | Yes | Form 4 |
| Khara RahulChief Legal Officer | Jun 18 | Jun 23 | S | 1,600 | $70.73 | Sale −$113,168 | 52,673 | Yes | Form 4 |
| Khara RahulChief Legal Officer | Jun 18 | Jun 23 | S | 500 | $71.62 | Sale −$35,810 | 52,173 | Yes | Form 4 |
| Khara RahulChief Legal Officer | Jun 18 | Jun 23 | M · derivative | 7,500 | $14.69 | $110,175 | 57,304 | Yes | Form 4 |
| Yu Jonathan Yen-WenChief Operating Officer | Jun 16 | Jun 18 | M | 5,261 | $9.86 | $51,873 | 59,585 | Yes | Form 4 |
| Yu Jonathan Yen-WenChief Operating Officer | Jun 16 | Jun 18 | M | 13,351 | $9.86 | $131,641 | 72,936 | Yes | Form 4 |
| Yu Jonathan Yen-WenChief Operating Officer | Jun 16 | Jun 18 | S | 11,651 | $68.76 | Sale −$801,123 | 61,285 | Yes | Form 4 |
| Yu Jonathan Yen-WenChief Operating Officer | Jun 16 | Jun 18 | S | 6,961 | $69.92 | Sale −$486,713 | 54,324 | Yes | Form 4 |
| Yu Jonathan Yen-WenChief Operating Officer | Jun 16 | Jun 18 | M · derivative | 5,261 | $9.86 | $51,873 | 1,753 | Yes | Form 4 |
| Yu Jonathan Yen-WenChief Operating Officer | Jun 16 | Jun 18 | M · derivative | 13,351 | $9.86 | $131,641 | 31,951 | Yes | Form 4 |
| Franchi Jean M.Chief Financial Officer | Apr 14 | Apr 15 | S | 6,257 | $69.24 | Sale −$433,235 | 64,333 | Yes | Form 4 |
| Franchi Jean M.Chief Financial Officer | Apr 13 | Apr 15 | S | 400 | $69.00 | Sale −$27,600 | 70,590 | Yes | Form 4 |
| Savage William JacobChief Medical Officer | Apr 13 | Apr 15 | S | 3,531 | $66.12 | Sale −$233,470 | 81,680 | Yes | Form 4 |
| Savage William JacobChief Medical Officer | Apr 13 | Apr 15 | S | 2,200 | $66.81 | Sale −$146,982 | 79,480 | Yes | Form 4 |
| Savage William JacobChief Medical Officer | Mar 2 | Mar 4 | S | 4,392 | $65.52 | Sale −$287,764 | 88,197 | Yes | Form 4 |
| Savage William JacobChief Medical Officer | Mar 2 | Mar 4 | S | 2,986 | $66.41 | Sale −$198,300 | 85,211 | Yes | Form 4 |
| Franchi Jean M.Chief Financial Officer | Feb 25 | Feb 27 | S | 353 | $69.06 | Sale −$24,378 | 70,990 | Yes | Form 4 |
| Franchi Jean M.Chief Financial Officer | Feb 18 | Feb 19 | S | 3,397 | $65.01 | Sale −$220,839 | 75,027 | Yes | Form 4 |
| Franchi Jean M.Chief Financial Officer | Feb 18 | Feb 19 | S | 3,684 | $65.89 | Sale −$242,739 | 71,343 | Yes | Form 4 |
| Franchi Jean M.Chief Financial Officer | Feb 17 | Feb 19 | S | 4,075 | $62.86 | Sale −$256,155 | 78,424 | Yes | Form 4 |
| Quisel John DChief Executive Officer | Feb 17 | Feb 17 | S | 13,264 | $62.86 | Sale −$833,775 | 226,064 | No | Form 4 |
| Yu Jonathan Yen-WenChief Operating Officer | Feb 17 | Feb 17 | S | 3,231 | $62.86 | Sale −$203,101 | 54,324 | No | Form 4 |
| Savage William JacobChief Medical Officer | Feb 17 | Feb 17 | S | 3,256 | $62.86 | Sale −$204,672 | 92,589 | No | Form 4 |
| Stephenson PamelaChief Commercial Officer | Feb 17 | Feb 17 | S | 5,531 | $62.86 | Sale −$347,679 | 80,998 | No | Form 4 |
| Khara RahulChief Legal Officer | Feb 17 | Feb 17 | S | 2,853 | $62.86 | Sale −$179,340 | 52,173 | No | Form 4 |
| Quisel John DChief Executive Officer | Feb 10 | Feb 11 | A | 55,200 | $0.00 | $0 | 239,328 | No | Form 4 |
| Quisel John DChief Executive Officer | Feb 10 | Feb 11 | A · derivative | 82,800 | $74.75 | $6,189,300 | 82,800 | No | Form 4 |
| Franchi Jean M.Chief Financial Officer | Feb 10 | Feb 11 | A | 19,000 | $0.00 | $0 | 82,499 | No | Form 4 |
| Franchi Jean M.Chief Financial Officer | Feb 10 | Feb 11 | A · derivative | 25,500 | $74.75 | $1,906,125 | 25,500 | No | Form 4 |
| Yu Jonathan Yen-WenChief Operating Officer | Feb 10 | Feb 11 | A | 17,000 | $0.00 | $0 | 57,555 | No | Form 4 |
| Yu Jonathan Yen-WenChief Operating Officer | Feb 10 | Feb 11 | A · derivative | 25,500 | $74.75 | $1,906,125 | 25,500 | No | Form 4 |
| Savage William JacobChief Medical Officer | Feb 10 | Feb 11 | A | 17,000 | $0.00 | $0 | 95,845 | No | Form 4 |
| Savage William JacobChief Medical Officer | Feb 10 | Feb 11 | A · derivative | 25,500 | $74.75 | $1,906,125 | 25,500 | No | Form 4 |
| Stephenson PamelaChief Commercial Officer | Feb 10 | Feb 11 | A | 17,000 | $0.00 | $0 | 86,529 | No | Form 4 |
| Stephenson PamelaChief Commercial Officer | Feb 10 | Feb 11 | A · derivative | 25,500 | $74.75 | $1,906,125 | 25,500 | No | Form 4 |
| Khara RahulChief Legal Officer | Feb 10 | Feb 11 | A | 17,000 | $0.00 | $0 | 55,026 | No | Form 4 |
| Khara RahulChief Legal Officer | Feb 10 | Feb 11 | A · derivative | 25,500 | $74.75 | $1,906,125 | 25,500 | No | Form 4 |
| Khara RahulChief Legal Officer | Jan 20 | Jan 21 | M | 1,000 | $13.50 | $13,500 | 38,793 | Yes | Form 4 |
| Khara RahulChief Legal Officer | Jan 20 | Jan 21 | S | 1,000 | $69.74 | Sale −$69,740 | 37,793 | Yes | Form 4 |
| Khara RahulChief Legal Officer | Jan 20 | Jan 21 | M · derivative | 1,000 | $13.50 | $13,500 | 21,270 | Yes | Form 4 |
| Khara RahulChief Legal Officer | Jan 2 | Jan 5 | M | 6,500 | $13.50 | $87,750 | 44,293 | Yes | Form 4 |
| Khara RahulChief Legal Officer | Jan 2 | Jan 5 | S | 350 | $77.67 | Sale −$27,185 | 43,943 | Yes | Form 4 |
| Khara RahulChief Legal Officer | Jan 2 | Jan 5 | S | 4,993 | $78.62 | Sale −$392,550 | 38,950 | Yes | Form 4 |
| Khara RahulChief Legal Officer | Jan 2 | Jan 5 | S | 1,157 | $79.27 | Sale −$91,715 | 37,793 | Yes | Form 4 |
| Khara RahulChief Legal Officer | Jan 2 | Jan 5 | M · derivative | 6,500 | $13.50 | $87,750 | 22,270 | Yes | Form 4 |
| Savage William JacobChief Medical Officer | Dec 22, 2025 | Dec 29, 2025 | M | 2,825 | $9.86 | $27,855 | 78,527 | No | Form 4 |
| Savage William JacobChief Medical Officer | Dec 22, 2025 | Dec 29, 2025 | M | 219 | $9.86 | $2,159 | 78,746 | No | Form 4 |
| Savage William JacobChief Medical Officer | Dec 22, 2025 | Dec 29, 2025 | M | 99 | $13.50 | $1,337 | 78,845 | No | Form 4 |
| Savage William JacobChief Medical Officer | Dec 22, 2025 | Dec 29, 2025 | M · derivative | 2,825 | $9.86 | $27,855 | 3,550 | No | Form 4 |
| Savage William JacobChief Medical Officer | Dec 22, 2025 | Dec 29, 2025 | M · derivative | 219 | $9.86 | $2,159 | 2,628 | No | Form 4 |
| Savage William JacobChief Medical Officer | Dec 22, 2025 | Dec 29, 2025 | M · derivative | 99 | $13.50 | $1,337 | 29,905 | No | Form 4 |
| Quisel John DChief Executive Officer | Dec 19, 2025 | Dec 19, 2025 | M | 12,300 | $1.01 | $12,423 | 184,128 | No | Form 4 |
| Quisel John DChief Executive Officer | Dec 19, 2025 | Dec 19, 2025 | M · derivative | 12,300 | $1.01 | $12,423 | 186,120 | No | Form 4 |
| Bitterman Kevin | Dec 17, 2025 | Dec 18, 2025 | S | 393 | $91.47 | Sale −$35,948 | 349,210 | No | Form 4 |
| Bitterman Kevin | Dec 17, 2025 | Dec 18, 2025 | S | 213 | $91.47 | Sale −$19,483 | 337,485 | No | Form 4 |
| Bitterman Kevin | Dec 17, 2025 | Dec 18, 2025 | S | 148 | $91.47 | Sale −$13,538 | 14,013 | No | Form 4 |
| Bitterman Kevin | Dec 16, 2025 | Dec 16, 2025 | S | 35,898 | $91.24 | Sale −$3,275,334 | 349,603 | No | Form 4 |
| Bitterman Kevin | Dec 16, 2025 | Dec 16, 2025 | S | 18,666 | $91.24 | Sale −$1,703,086 | 337,698 | No | Form 4 |
| Bitterman Kevin | Dec 16, 2025 | Dec 16, 2025 | S | 14,359 | $91.24 | Sale −$1,310,115 | 14,161 | No | Form 4 |
| Bitterman Kevin | Dec 15, 2025 | Dec 16, 2025 | S | 28,913 | $91.18 | Sale −$2,636,287 | 389,422 | No | Form 4 |
| Bitterman Kevin | Dec 15, 2025 | Dec 16, 2025 | S | 3,921 | $92.01 | Sale −$360,771 | 385,501 | No | Form 4 |
| Bitterman Kevin | Dec 15, 2025 | Dec 16, 2025 | S | 14,811 | $91.18 | Sale −$1,350,467 | 358,413 | No | Form 4 |
| Bitterman Kevin | Dec 15, 2025 | Dec 16, 2025 | S | 2,049 | $92.01 | Sale −$188,528 | 356,364 | No | Form 4 |
| Bitterman Kevin | Dec 15, 2025 | Dec 16, 2025 | S | 11,427 | $91.18 | Sale −$1,041,914 | 30,092 | No | Form 4 |
| Bitterman Kevin | Dec 15, 2025 | Dec 16, 2025 | S | 1,572 | $92.01 | Sale −$144,640 | 28,520 | No | Form 4 |
| Bitterman Kevin | Dec 15, 2025 | Dec 16, 2025 | M | 7,000 | $13.50 | $94,500 | 7,000 | No | Form 4 |
| Bitterman Kevin | Dec 15, 2025 | Dec 16, 2025 | S | 7,000 | $91.87 | Sale −$643,090 | not reported | No | Form 4 |
| Bitterman Kevin | Dec 15, 2025 | Dec 16, 2025 | M · derivative | 7,000 | $13.50 | $94,500 | not reported | No | Form 4 |
| Savage William JacobChief Medical Officer | Dec 15, 2025 | Dec 16, 2025 | S | 3,642 | $90.60 | Sale −$329,965 | 85,153 | Yes | Form 4 |
| Savage William JacobChief Medical Officer | Dec 15, 2025 | Dec 16, 2025 | S | 9,151 | $91.44 | Sale −$836,767 | 76,002 | Yes | Form 4 |
| Savage William JacobChief Medical Officer | Dec 15, 2025 | Dec 16, 2025 | S | 300 | $92.23 | Sale −$27,669 | 75,702 | Yes | Form 4 |
| Bitterman Kevin | Dec 12, 2025 | Dec 16, 2025 | S | 16,403 | $92.05 | Sale −$1,509,896 | 425,633 | No | Form 4 |
| Bitterman Kevin | Dec 12, 2025 | Dec 16, 2025 | S | 3,852 | $92.58 | Sale −$356,618 | 421,781 | No | Form 4 |
| Bitterman Kevin | Dec 12, 2025 | Dec 16, 2025 | S | 3,446 | $93.80 | Sale −$323,235 | 418,335 | No | Form 4 |
| Bitterman Kevin | Dec 12, 2025 | Dec 16, 2025 | S | 8,527 | $92.05 | Sale −$784,910 | 377,022 | No | Form 4 |
| Bitterman Kevin | Dec 12, 2025 | Dec 16, 2025 | S | 2,005 | $92.58 | Sale −$185,623 | 375,017 | No | Form 4 |
| Bitterman Kevin | Dec 12, 2025 | Dec 16, 2025 | S | 1,793 | $93.80 | Sale −$168,183 | 373,224 | No | Form 4 |
| Bitterman Kevin | Dec 12, 2025 | Dec 16, 2025 | S | 6,570 | $92.05 | Sale −$604,769 | 44,430 | No | Form 4 |
| Bitterman Kevin | Dec 12, 2025 | Dec 16, 2025 | S | 1,540 | $92.58 | Sale −$142,573 | 42,890 | No | Form 4 |
| Bitterman Kevin | Dec 12, 2025 | Dec 16, 2025 | S | 1,371 | $93.80 | Sale −$128,600 | 41,519 | No | Form 4 |
| Quisel John DChief Executive Officer | Dec 11, 2025 | Dec 15, 2025 | M | 40,000 | $9.86 | $394,400 | 211,828 | Yes | Form 4 |
| Quisel John DChief Executive Officer | Dec 11, 2025 | Dec 15, 2025 | S | 2,419 | $90.97 | Sale −$220,056 | 209,409 | Yes | Form 4 |
| Quisel John DChief Executive Officer | Dec 11, 2025 | Dec 15, 2025 | S | 4,337 | $92.21 | Sale −$399,915 | 205,072 | Yes | Form 4 |
| Quisel John DChief Executive Officer | Dec 11, 2025 | Dec 15, 2025 | S | 16,356 | $92.96 | Sale −$1,520,454 | 188,716 | Yes | Form 4 |
| Quisel John DChief Executive Officer | Dec 11, 2025 | Dec 15, 2025 | S | 16,888 | $93.65 | Sale −$1,581,561 | 171,828 | Yes | Form 4 |
| Quisel John DChief Executive Officer | Dec 11, 2025 | Dec 15, 2025 | M · derivative | 40,000 | $9.86 | $394,400 | 75,375 | Yes | Form 4 |
| Yu Jonathan Yen-WenChief Operating Officer | Nov 11, 2025 | Nov 13, 2025 | M | 30,000 | $2.65 | $79,500 | 70,555 | Yes | Form 4 |
| Yu Jonathan Yen-WenChief Operating Officer | Nov 11, 2025 | Nov 13, 2025 | S | 8,015 | $83.15 | Sale −$666,447 | 62,540 | Yes | Form 4 |
| Yu Jonathan Yen-WenChief Operating Officer | Nov 11, 2025 | Nov 13, 2025 | S | 4,585 | $83.99 | Sale −$385,094 | 57,955 | Yes | Form 4 |
| Yu Jonathan Yen-WenChief Operating Officer | Nov 11, 2025 | Nov 13, 2025 | S | 9,360 | $85.33 | Sale −$798,689 | 48,595 | Yes | Form 4 |
| Yu Jonathan Yen-WenChief Operating Officer | Nov 11, 2025 | Nov 13, 2025 | S | 8,040 | $85.91 | Sale −$690,716 | 40,555 | Yes | Form 4 |
| Yu Jonathan Yen-WenChief Operating Officer | Nov 11, 2025 | Nov 13, 2025 | M · derivative | 30,000 | $2.65 | $79,500 | 7,941 | Yes | Form 4 |
| Ai Dmi LLC | Oct 22, 2025 | Oct 24, 2025 | S | 744,047 | $80.47 | Sale −$59,873,462 | 2,814,379 | No | Form 4 |
| Bitterman Kevin | Oct 17, 2025 | Oct 17, 2025 | S | 1,125 | $84.89 | Sale −$95,501 | 475,911 | No | Form 4 |
| Bitterman Kevin | Oct 17, 2025 | Oct 17, 2025 | S | 1,125 | $84.89 | Sale −$95,501 | 419,424 | No | Form 4 |
| Bitterman Kevin | Oct 17, 2025 | Oct 17, 2025 | S | 3,000 | $86.13 | Sale −$258,390 | 472,911 | No | Form 4 |
| Bitterman Kevin | Oct 17, 2025 | Oct 17, 2025 | S | 3,000 | $86.13 | Sale −$258,390 | 416,424 | No | Form 4 |
| Bitterman Kevin | Oct 17, 2025 | Oct 17, 2025 | S | 5,066 | $87.37 | Sale −$442,616 | 467,845 | No | Form 4 |
| Bitterman Kevin | Oct 17, 2025 | Oct 17, 2025 | S | 5,065 | $87.37 | Sale −$442,529 | 411,359 | No | Form 4 |
| Bitterman Kevin | Oct 17, 2025 | Oct 17, 2025 | S | 13,014 | $88.91 | Sale −$1,157,075 | 454,831 | No | Form 4 |
| Bitterman Kevin | Oct 17, 2025 | Oct 17, 2025 | S | 13,014 | $88.91 | Sale −$1,157,075 | 398,345 | No | Form 4 |
| Bitterman Kevin | Oct 17, 2025 | Oct 17, 2025 | S | 2,251 | $89.70 | Sale −$201,915 | 452,580 | No | Form 4 |
| Bitterman Kevin | Oct 17, 2025 | Oct 17, 2025 | S | 2,251 | $89.70 | Sale −$201,915 | 396,094 | No | Form 4 |
| Bitterman Kevin | Oct 17, 2025 | Oct 17, 2025 | S | 10,094 | $90.66 | Sale −$915,122 | 442,486 | No | Form 4 |
| Bitterman Kevin | Oct 17, 2025 | Oct 17, 2025 | S | 10,095 | $90.66 | Sale −$915,213 | 385,999 | No | Form 4 |
| Bitterman Kevin | Oct 17, 2025 | Oct 17, 2025 | S | 450 | $91.88 | Sale −$41,346 | 442,036 | No | Form 4 |
| Bitterman Kevin | Oct 17, 2025 | Oct 17, 2025 | S | 450 | $91.88 | Sale −$41,346 | 385,549 | No | Form 4 |
| Bitterman Kevin | Oct 16, 2025 | Oct 17, 2025 | S | 1,425 | $77.11 | Sale −$109,882 | 477,036 | No | Form 4 |
| Bitterman Kevin | Oct 15, 2025 | Oct 17, 2025 | S | 19,542 | $77.16 | Sale −$1,507,861 | 481,079 | No | Form 4 |
| Bitterman Kevin | Oct 15, 2025 | Oct 17, 2025 | S | 2,618 | $77.76 | Sale −$203,576 | 478,461 | No | Form 4 |
| Bitterman Kevin | Oct 8, 2025 | Oct 9, 2025 | S | 8,219 | $68.26 | Sale −$561,029 | 564,363 | No | Form 4 |
| Bitterman Kevin | Oct 8, 2025 | Oct 9, 2025 | S | 12,386 | $69.31 | Sale −$858,474 | 551,977 | No | Form 4 |
| Bitterman Kevin | Oct 8, 2025 | Oct 9, 2025 | S | 25,400 | $70.54 | Sale −$1,791,716 | 526,577 | No | Form 4 |
| Bitterman Kevin | Oct 8, 2025 | Oct 9, 2025 | S | 12,689 | $71.51 | Sale −$907,390 | 513,888 | No | Form 4 |
| Bitterman Kevin | Oct 8, 2025 | Oct 9, 2025 | S | 13,267 | $72.39 | Sale −$960,398 | 500,621 | No | Form 4 |
| Bitterman Kevin | Oct 7, 2025 | Oct 9, 2025 | S | 11,378 | $68.01 | Sale −$773,818 | 579,243 | No | Form 4 |
| Bitterman Kevin | Oct 7, 2025 | Oct 9, 2025 | S | 6,661 | $69.01 | Sale −$459,676 | 572,582 | No | Form 4 |
| Gemayel Georges | Sep 16, 2025 | Sep 18, 2025 | A · derivative | 1,000 | $60.34 | $60,340 | 1,000 | No | Form 4 |
| Quisel John DChief Executive Officer | Sep 9, 2025 | Sep 11, 2025 | M | 10,000 | $1.01 | $10,100 | 171,828 | No | Form 4 |
| Quisel John DChief Executive Officer | Sep 9, 2025 | Sep 11, 2025 | M · derivative | 10,000 | $1.01 | $10,100 | 198,420 | No | Form 4 |
| Bitterman Kevin | Aug 22, 2025 | Aug 26, 2025 | S | 2,287 | $61.03 | Sale −$139,576 | 590,621 | Yes | Form 4 |
| Bitterman Kevin | Aug 14, 2025 | Aug 15, 2025 | S | 7,212 | $60.99 | Sale −$439,860 | 592,908 | Yes | Form 4 |
| Bitterman Kevin | Aug 13, 2025 | Aug 15, 2025 | S | 24,962 | $61.15 | Sale −$1,526,426 | 600,120 | Yes | Form 4 |
| Bitterman Kevin | Aug 5, 2025 | Aug 7, 2025 | S | 395 | $60.95 | Sale −$24,075 | 625,082 | Yes | Form 4 |
| Bitterman Kevin | Jul 30, 2025 | Aug 1, 2025 | S | 8,492 | $61.04 | Sale −$518,352 | 625,477 | Yes | Form 4 |
| Bitterman Kevin | Jul 24, 2025 | Jul 25, 2025 | S | 13,033 | $61.17 | Sale −$797,229 | 633,969 | No | Form 4 |
| Bitterman Kevin | Jul 23, 2025 | Jul 25, 2025 | S | 29,837 | $60.97 | Sale −$1,819,162 | 647,002 | No | Form 4 |
| Bitterman Kevin | Jul 18, 2025 | Jul 22, 2025 | S | 664 | $61.13 | Sale −$40,590 | 676,839 | No | Form 4 |
| Franchi Jean M.Chief Financial Officer | Jul 17, 2025 | Jul 18, 2025 | S | 2,031 | $59.00 | Sale −$119,829 | 63,499 | Yes | Form 4 |
| Ahmed Nadim | Jul 14, 2025 | Jul 16, 2025 | A · derivative | 20,000 | $57.74 | $1,154,800 | 20,000 | No | Form 4 |
| Franchi Jean M.Chief Financial Officer | Jul 10, 2025 | Jul 14, 2025 | S | 2,000 | $57.50 | Sale −$115,000 | 65,530 | Yes | Form 4 |
| Quisel John DChief Executive Officer | Jul 9, 2025 | Jul 11, 2025 | M | 34,800 | $9.86 | $343,128 | 196,628 | Yes | Form 4 |
| Quisel John DChief Executive Officer | Jul 9, 2025 | Jul 11, 2025 | S | 31,207 | $55.23 | Sale −$1,723,563 | 165,421 | Yes | Form 4 |
| Quisel John DChief Executive Officer | Jul 9, 2025 | Jul 11, 2025 | S | 3,593 | $56.20 | Sale −$201,927 | 161,828 | Yes | Form 4 |
| Quisel John DChief Executive Officer | Jul 9, 2025 | Jul 11, 2025 | M · derivative | 34,800 | $9.86 | $343,128 | 115,375 | Yes | Form 4 |
| Quisel John DChief Executive Officer | Jul 3, 2025 | Jul 8, 2025 | M | 5,200 | $9.86 | $51,272 | 167,028 | Yes | Form 4 |
| Quisel John DChief Executive Officer | Jul 3, 2025 | Jul 8, 2025 | S | 5,200 | $55.09 | Sale −$286,468 | 161,828 | Yes | Form 4 |
| Quisel John DChief Executive Officer | Jul 3, 2025 | Jul 8, 2025 | M · derivative | 5,200 | $9.86 | $51,272 | 150,175 | Yes | Form 4 |
| Savage William JacobChief Medical Officer | Jun 27, 2025 | Jul 1, 2025 | M | 29,659 | $9.86 | $292,438 | 86,384 | No | Form 4 |
| Savage William JacobChief Medical Officer | Jun 27, 2025 | Jul 1, 2025 | M | 2,411 | $9.86 | $23,772 | 88,795 | No | Form 4 |
| Savage William JacobChief Medical Officer | Jun 27, 2025 | Jul 1, 2025 | M · derivative | 29,659 | $9.86 | $292,438 | 6,375 | No | Form 4 |
| Savage William JacobChief Medical Officer | Jun 27, 2025 | Jul 1, 2025 | M · derivative | 2,411 | $9.86 | $23,772 | 2,847 | No | Form 4 |
| Franchi Jean M.Chief Financial Officer | Jun 16, 2025 | Jun 18, 2025 | S | 2,000 | $52.26 | Sale −$104,520 | 67,530 | Yes | Form 4 |
| Ashiya Mona | Jun 11, 2025 | Jun 13, 2025 | A · derivative | 10,000 | $50.86 | $508,600 | 10,000 | No | Form 4 |
| Bitterman Kevin | Jun 11, 2025 | Jun 13, 2025 | A · derivative | 10,000 | $50.86 | $508,600 | 10,000 | No | Form 4 |
| Chin Mark | Jun 11, 2025 | Jun 13, 2025 | A · derivative | 10,000 | $50.86 | $508,600 | 10,000 | No | Form 4 |
| Gemayel Georges | Jun 11, 2025 | Jun 13, 2025 | A · derivative | 10,000 | $50.86 | $508,600 | 10,000 | No | Form 4 |
| Nicholson Donald William | Jun 11, 2025 | Jun 13, 2025 | A · derivative | 10,000 | $50.86 | $508,600 | 10,000 | No | Form 4 |
| Ratcliffe Liam | Jun 11, 2025 | Jun 13, 2025 | A · derivative | 10,000 | $50.86 | $508,600 | 10,000 | No | Form 4 |
| White William Richard | Jun 11, 2025 | Jun 13, 2025 | A · derivative | 10,000 | $50.86 | $508,600 | 10,000 | No | Form 4 |
| Savage William JacobChief Medical Officer | Jun 6, 2025 | Jun 9, 2025 | S | 2,996 | $50.00 | Sale −$149,800 | 56,725 | Yes | Form 4 |
| Savage William JacobChief Medical Officer | May 20, 2025 | May 22, 2025 | S | 6,677 | $50.04 | Sale −$334,117 | 59,721 | Yes | Form 4 |
| Savage William JacobChief Medical Officer | May 2, 2025 | May 6, 2025 | S | 2,100 | $50.17 | Sale −$105,357 | 66,398 | Yes | Form 4 |
| Quisel John DChief Executive Officer | Apr 7, 2025 | Apr 8, 2025 | M | 7,000 | $1.01 | $7,070 | 161,828 | No | Form 4 |
| Quisel John DChief Executive Officer | Apr 7, 2025 | Apr 8, 2025 | M · derivative | 7,000 | $1.01 | $7,070 | 208,420 | No | Form 4 |
| Orbimed Advisors LLC | Mar 24, 2025 | Mar 26, 2025 | S | 1,956 | $54.11 | Sale −$105,839 | 482,308 | No | Form 4 |
| Orbimed Advisors LLC | Mar 24, 2025 | Mar 26, 2025 | S | 3,026 | $54.11 | Sale −$163,737 | 746,171 | No | Form 4 |
| Orbimed Advisors LLC | Mar 24, 2025 | Mar 26, 2025 | S | 756 | $54.11 | Sale −$40,907 | 186,541 | No | Form 4 |
| Ashiya Mona | Mar 24, 2025 | Mar 26, 2025 | S | 1,956 | $54.11 | Sale −$105,839 | 482,308 | No | Form 4 |
| Ashiya Mona | Mar 24, 2025 | Mar 26, 2025 | S | 3,026 | $54.11 | Sale −$163,737 | 746,171 | No | Form 4 |
| Ashiya Mona | Mar 24, 2025 | Mar 26, 2025 | S | 756 | $54.11 | Sale −$40,907 | 186,541 | No | Form 4 |
| OrbiMed Capital GP VI LLC | Mar 21, 2025 | Mar 21, 2025 | S | 3,412 | $54.00 | Sale −$184,248 | 484,264 | No | Form 4 |
| OrbiMed Capital GP VI LLC | Mar 21, 2025 | Mar 21, 2025 | S | 5,279 | $54.00 | Sale −$285,066 | 749,197 | No | Form 4 |
| OrbiMed Capital GP VI LLC | Mar 21, 2025 | Mar 21, 2025 | S | 1,320 | $54.00 | Sale −$71,280 | 187,297 | No | Form 4 |
| Ashiya Mona | Mar 21, 2025 | Mar 21, 2025 | S | 3,412 | $54.00 | Sale −$184,248 | 484,264 | No | Form 4 |
| Ashiya Mona | Mar 21, 2025 | Mar 21, 2025 | S | 5,279 | $54.00 | Sale −$285,066 | 749,197 | No | Form 4 |
| Ashiya Mona | Mar 21, 2025 | Mar 21, 2025 | S | 1,320 | $54.00 | Sale −$71,280 | 187,297 | No | Form 4 |
| OrbiMed Capital GP VI LLC | Mar 20, 2025 | Mar 21, 2025 | S | 941 | $54.01 | Sale −$50,823 | 487,676 | No | Form 4 |
| OrbiMed Capital GP VI LLC | Mar 20, 2025 | Mar 21, 2025 | S | 1,457 | $54.01 | Sale −$78,693 | 754,476 | No | Form 4 |
| OrbiMed Capital GP VI LLC | Mar 20, 2025 | Mar 21, 2025 | S | 364 | $54.01 | Sale −$19,660 | 188,617 | No | Form 4 |
| Ashiya Mona | Mar 20, 2025 | Mar 21, 2025 | S | 941 | $54.01 | Sale −$50,823 | 487,676 | No | Form 4 |
| Ashiya Mona | Mar 20, 2025 | Mar 21, 2025 | S | 1,457 | $54.01 | Sale −$78,693 | 754,476 | No | Form 4 |
| Ashiya Mona | Mar 20, 2025 | Mar 21, 2025 | S | 364 | $54.01 | Sale −$19,660 | 188,617 | No | Form 4 |
| OrbiMed Capital GP VI LLC | Mar 19, 2025 | Mar 21, 2025 | S | 13,517 | $54.02 | Sale −$730,188 | 488,617 | No | Form 4 |
| OrbiMed Capital GP VI LLC | Mar 19, 2025 | Mar 21, 2025 | S | 20,911 | $54.02 | Sale −$1,129,612 | 755,933 | No | Form 4 |
| OrbiMed Capital GP VI LLC | Mar 19, 2025 | Mar 21, 2025 | S | 5,228 | $54.02 | Sale −$282,417 | 188,981 | No | Form 4 |
| Ashiya Mona | Mar 19, 2025 | Mar 21, 2025 | S | 13,517 | $54.02 | Sale −$730,188 | 488,617 | No | Form 4 |
| Ashiya Mona | Mar 19, 2025 | Mar 21, 2025 | S | 20,911 | $54.02 | Sale −$1,129,612 | 755,933 | No | Form 4 |
| Ashiya Mona | Mar 19, 2025 | Mar 21, 2025 | S | 5,228 | $54.02 | Sale −$282,417 | 188,981 | No | Form 4 |
| OrbiMed Capital GP VI LLC | Mar 12, 2025 | Mar 12, 2025 | S | 603 | $55.05 | Sale −$33,195 | 529,884 | No | Form 4 |
| OrbiMed Capital GP VI LLC | Mar 12, 2025 | Mar 12, 2025 | S | 933 | $55.05 | Sale −$51,362 | 819,774 | No | Form 4 |
| OrbiMed Capital GP VI LLC | Mar 12, 2025 | Mar 12, 2025 | S | 233 | $55.05 | Sale −$12,827 | 204,942 | No | Form 4 |
| OrbiMed Capital GP VI LLC | Mar 12, 2025 | Mar 12, 2025 | S | 27,750 | $54.44 | Sale −$1,510,710 | 502,134 | No | Form 4 |
| OrbiMed Capital GP VI LLC | Mar 12, 2025 | Mar 12, 2025 | S | 42,930 | $54.44 | Sale −$2,337,109 | 776,844 | No | Form 4 |
| OrbiMed Capital GP VI LLC | Mar 12, 2025 | Mar 12, 2025 | S | 10,733 | $54.44 | Sale −$584,305 | 194,209 | No | Form 4 |
| Ashiya Mona | Mar 12, 2025 | Mar 12, 2025 | S | 603 | $55.05 | Sale −$33,195 | 529,884 | No | Form 4 |
| Ashiya Mona | Mar 12, 2025 | Mar 12, 2025 | S | 933 | $55.05 | Sale −$51,362 | 819,774 | No | Form 4 |
| Ashiya Mona | Mar 12, 2025 | Mar 12, 2025 | S | 233 | $55.05 | Sale −$12,827 | 204,942 | No | Form 4 |
| Ashiya Mona | Mar 12, 2025 | Mar 12, 2025 | S | 27,750 | $54.44 | Sale −$1,510,710 | 502,134 | No | Form 4 |
| Ashiya Mona | Mar 12, 2025 | Mar 12, 2025 | S | 42,930 | $54.44 | Sale −$2,337,109 | 776,844 | No | Form 4 |
| Ashiya Mona | Mar 12, 2025 | Mar 12, 2025 | S | 10,733 | $54.44 | Sale −$584,305 | 194,209 | No | Form 4 |
| OrbiMed Capital GP VI LLC | Mar 11, 2025 | Mar 12, 2025 | S | 9,222 | $54.01 | Sale −$498,080 | 530,487 | No | Form 4 |
| OrbiMed Capital GP VI LLC | Mar 11, 2025 | Mar 12, 2025 | S | 14,267 | $54.01 | Sale −$770,561 | 820,707 | No | Form 4 |
| OrbiMed Capital GP VI LLC | Mar 11, 2025 | Mar 12, 2025 | S | 3,567 | $54.01 | Sale −$192,654 | 205,175 | No | Form 4 |
| Ashiya Mona | Mar 11, 2025 | Mar 12, 2025 | S | 9,222 | $54.01 | Sale −$498,080 | 530,487 | No | Form 4 |
| Ashiya Mona | Mar 11, 2025 | Mar 12, 2025 | S | 14,267 | $54.01 | Sale −$770,561 | 820,707 | No | Form 4 |
| Ashiya Mona | Mar 11, 2025 | Mar 12, 2025 | S | 3,567 | $54.01 | Sale −$192,654 | 205,175 | No | Form 4 |
| OrbiMed Capital GP VI LLC | Mar 10, 2025 | Mar 12, 2025 | S | 68,766 | $54.29 | Sale −$3,733,306 | 539,845 | No | Form 4 |
| OrbiMed Capital GP VI LLC | Mar 10, 2025 | Mar 12, 2025 | S | 106,384 | $54.29 | Sale −$5,775,587 | 835,185 | No | Form 4 |
| OrbiMed Capital GP VI LLC | Mar 10, 2025 | Mar 12, 2025 | S | 26,596 | $54.29 | Sale −$1,443,897 | 208,795 | No | Form 4 |
| OrbiMed Capital GP VI LLC | Mar 10, 2025 | Mar 12, 2025 | S | 136 | $55.01 | Sale −$7,481 | 539,709 | No | Form 4 |
| OrbiMed Capital GP VI LLC | Mar 10, 2025 | Mar 12, 2025 | S | 211 | $55.01 | Sale −$11,607 | 834,974 | No | Form 4 |
| OrbiMed Capital GP VI LLC | Mar 10, 2025 | Mar 12, 2025 | S | 53 | $55.01 | Sale −$2,916 | 208,742 | No | Form 4 |
| Ashiya Mona | Mar 10, 2025 | Mar 12, 2025 | S | 68,766 | $54.29 | Sale −$3,733,306 | 539,845 | No | Form 4 |
| Ashiya Mona | Mar 10, 2025 | Mar 12, 2025 | S | 106,384 | $54.29 | Sale −$5,775,587 | 835,185 | No | Form 4 |
| Ashiya Mona | Mar 10, 2025 | Mar 12, 2025 | S | 26,596 | $54.29 | Sale −$1,443,897 | 208,795 | No | Form 4 |
| Ashiya Mona | Mar 10, 2025 | Mar 12, 2025 | S | 136 | $55.01 | Sale −$7,481 | 539,709 | No | Form 4 |
| Ashiya Mona | Mar 10, 2025 | Mar 12, 2025 | S | 211 | $55.01 | Sale −$11,607 | 834,974 | No | Form 4 |
| Ashiya Mona | Mar 10, 2025 | Mar 12, 2025 | S | 53 | $55.01 | Sale −$2,916 | 208,742 | No | Form 4 |
| Quisel John DChief Executive Officer | Feb 18, 2025 | Feb 20, 2025 | S | 5,574 | $54.58 | Sale −$304,229 | 154,828 | No | Form 4 |
| Franchi Jean M.Chief Financial Officer | Feb 18, 2025 | Feb 20, 2025 | S | 3,136 | $54.58 | Sale −$171,163 | 69,530 | No | Form 4 |
| Yu Jonathan Yen-WenChief Operating Officer | Feb 18, 2025 | Feb 20, 2025 | S | 1,610 | $54.58 | Sale −$87,874 | 40,555 | No | Form 4 |
| Savage William JacobChief Medical Officer | Feb 18, 2025 | Feb 20, 2025 | S | 1,638 | $54.58 | Sale −$89,402 | 68,498 | No | Form 4 |
| Khara RahulChief Legal Officer | Feb 18, 2025 | Feb 20, 2025 | S | 1,161 | $54.58 | Sale −$63,367 | 37,583 | No | Form 4 |
| Stephenson PamelaChief Commercial Officer | Feb 18, 2025 | Feb 20, 2025 | S | 3,137 | $54.58 | Sale −$171,217 | 69,529 | No | Form 4 |
| Savage William JacobChief Medical Officer | Feb 10, 2025 | Feb 12, 2025 | A | 24,000 | $0.00 | $0 | 70,136 | No | Form 4 |
| Savage William JacobChief Medical Officer | Feb 10, 2025 | Feb 12, 2025 | A · derivative | 36,000 | $54.71 | $1,969,560 | 36,000 | No | Form 4 |
| Quisel John DChief Executive Officer | Feb 10, 2025 | Feb 12, 2025 | A | 78,337 | $0.00 | $0 | 160,402 | No | Form 4 |
| Quisel John DChief Executive Officer | Feb 10, 2025 | Feb 12, 2025 | A · derivative | 117,505 | $54.71 | $6,428,699 | 117,505 | No | Form 4 |
| Franchi Jean M.Chief Financial Officer | Feb 10, 2025 | Feb 12, 2025 | A | 36,000 | $0.00 | $0 | 72,666 | No | Form 4 |
| Franchi Jean M.Chief Financial Officer | Feb 10, 2025 | Feb 12, 2025 | A · derivative | 36,000 | $54.71 | $1,969,560 | 36,000 | No | Form 4 |
| Yu Jonathan Yen-WenChief Operating Officer | Feb 10, 2025 | Feb 12, 2025 | A | 24,000 | $0.00 | $0 | 42,165 | No | Form 4 |
| Yu Jonathan Yen-WenChief Operating Officer | Feb 10, 2025 | Feb 12, 2025 | A · derivative | 36,000 | $54.71 | $1,969,560 | 36,000 | No | Form 4 |
| Khara RahulChief Legal Officer | Feb 10, 2025 | Feb 12, 2025 | A | 24,000 | $0.00 | $0 | 38,035 | No | Form 4 |
| Khara RahulChief Legal Officer | Feb 10, 2025 | Feb 12, 2025 | A · derivative | 36,000 | $54.71 | $1,969,560 | 36,000 | No | Form 4 |
| Stephenson PamelaChief Commercial Officer | Feb 10, 2025 | Feb 12, 2025 | A | 36,000 | $0.00 | $0 | 72,666 | No | Form 4 |
| Stephenson PamelaChief Commercial Officer | Feb 10, 2025 | Feb 12, 2025 | A · derivative | 36,000 | $54.71 | $1,969,560 | 36,000 | No | Form 4 |
| Savage William JacobChief Medical Officer | Feb 3, 2025 | Feb 12, 2025 | M | 4,233 | $2.65 | $11,217 | 44,638 | No | Form 4 |
| Savage William JacobChief Medical Officer | Feb 3, 2025 | Feb 12, 2025 | M | 1,498 | $2.65 | $3,970 | 46,136 | No | Form 4 |
| Savage William JacobChief Medical Officer | Feb 3, 2025 | Feb 12, 2025 | M · derivative | 4,233 | $2.65 | $11,217 | not reported | No | Form 4 |
| Savage William JacobChief Medical Officer | Feb 3, 2025 | Feb 12, 2025 | M · derivative | 1,498 | $2.65 | $3,970 | not reported | No | Form 4 |
| Khara RahulChief Legal Officer | Feb 3, 2025 | Feb 4, 2025 | M | 7,500 | $14.69 | $110,175 | 21,535 | Yes | Form 4 |
| Khara RahulChief Legal Officer | Feb 3, 2025 | Feb 4, 2025 | S | 5,687 | $55.40 | Sale −$315,060 | 15,848 | Yes | Form 4 |
| Khara RahulChief Legal Officer | Feb 3, 2025 | Feb 4, 2025 | S | 1,813 | $56.01 | Sale −$101,546 | 14,035 | Yes | Form 4 |
| Khara RahulChief Legal Officer | Feb 3, 2025 | Feb 4, 2025 | M · derivative | 7,500 | $14.69 | $110,175 | 64,804 | Yes | Form 4 |
| Khara RahulChief Legal Officer | Jan 2, 2025 | Jan 6, 2025 | M | 7,500 | $14.69 | $110,175 | 21,535 | Yes | Form 4 |
| Khara RahulChief Legal Officer | Jan 2, 2025 | Jan 6, 2025 | S | 4,000 | $61.96 | Sale −$247,840 | 17,535 | Yes | Form 4 |
| Khara RahulChief Legal Officer | Jan 2, 2025 | Jan 6, 2025 | S | 1,400 | $62.95 | Sale −$88,130 | 16,135 | Yes | Form 4 |
| Khara RahulChief Legal Officer | Jan 2, 2025 | Jan 6, 2025 | S | 2,100 | $64.13 | Sale −$134,673 | 14,035 | Yes | Form 4 |
| Khara RahulChief Legal Officer | Jan 2, 2025 | Jan 6, 2025 | M · derivative | 7,500 | $14.69 | $110,175 | 72,304 | Yes | Form 4 |
| Quisel John DChief Executive Officer | Dec 31, 2024 | Jan 2, 2025 | M | 10,000 | $1.01 | $10,100 | 82,065 | Yes | Form 4 |
| Quisel John DChief Executive Officer | Dec 31, 2024 | Jan 2, 2025 | M · derivative | 10,000 | $1.01 | $10,100 | 215,420 | Yes | Form 4 |
| Quisel John DChief Executive Officer | Dec 30, 2024 | Jan 2, 2025 | M | 13,012 | $9.86 | $128,298 | 85,077 | Yes | Form 4 |
| Quisel John DChief Executive Officer | Dec 30, 2024 | Jan 2, 2025 | S | 11,112 | $61.87 | Sale −$687,499 | 73,965 | Yes | Form 4 |
| Quisel John DChief Executive Officer | Dec 30, 2024 | Jan 2, 2025 | S | 1,900 | $62.41 | Sale −$118,579 | 72,065 | Yes | Form 4 |
| Quisel John DChief Executive Officer | Dec 30, 2024 | Jan 2, 2025 | M · derivative | 13,012 | $9.86 | $128,298 | 155,375 | Yes | Form 4 |
| Quisel John DChief Executive Officer | Dec 23, 2024 | Dec 26, 2024 | M | 19,820 | $2.65 | $52,523 | 91,885 | Yes | Form 4 |
| Quisel John DChief Executive Officer | Dec 23, 2024 | Dec 26, 2024 | S | 3,414 | $62.38 | Sale −$212,965 | 88,471 | Yes | Form 4 |
| Quisel John DChief Executive Officer | Dec 23, 2024 | Dec 26, 2024 | S | 12,194 | $63.12 | Sale −$769,685 | 76,277 | Yes | Form 4 |
| Quisel John DChief Executive Officer | Dec 23, 2024 | Dec 26, 2024 | S | 4,212 | $63.80 | Sale −$268,726 | 72,065 | Yes | Form 4 |
| Quisel John DChief Executive Officer | Dec 23, 2024 | Dec 26, 2024 | M · derivative | 19,820 | $2.65 | $52,523 | 41,830 | Yes | Form 4 |
| Quisel John DChief Executive Officer | Dec 16, 2024 | Dec 18, 2024 | M | 12,791 | $1.01 | $12,919 | 84,856 | Yes | Form 4 |
| Quisel John DChief Executive Officer | Dec 16, 2024 | Dec 18, 2024 | S | 219 | $64.66 | Sale −$14,161 | 84,637 | Yes | Form 4 |
| Quisel John DChief Executive Officer | Dec 16, 2024 | Dec 18, 2024 | S | 5,767 | $65.58 | Sale −$378,200 | 78,870 | Yes | Form 4 |
| Quisel John DChief Executive Officer | Dec 16, 2024 | Dec 18, 2024 | S | 6,305 | $66.35 | Sale −$418,337 | 72,565 | Yes | Form 4 |
| Quisel John DChief Executive Officer | Dec 16, 2024 | Dec 18, 2024 | S | 500 | $67.20 | Sale −$33,600 | 72,065 | Yes | Form 4 |
| Quisel John DChief Executive Officer | Dec 16, 2024 | Dec 18, 2024 | M · derivative | 12,791 | $1.01 | $12,919 | 225,420 | Yes | Form 4 |
| White William Richard | Dec 2, 2024 | Dec 4, 2024 | M | 1,756 | $2.65 | $4,653 | 1,756 | Yes | Form 4 |
| White William Richard | Dec 2, 2024 | Dec 4, 2024 | M | 201 | $9.86 | $1,982 | 1,957 | Yes | Form 4 |
| White William Richard | Dec 2, 2024 | Dec 4, 2024 | S | 22 | $63.49 | Sale −$1,397 | 1,935 | Yes | Form 4 |
| White William Richard | Dec 2, 2024 | Dec 4, 2024 | S | 1,762 | $64.58 | Sale −$113,790 | 173 | Yes | Form 4 |
| White William Richard | Dec 2, 2024 | Dec 4, 2024 | S | 173 | $65.33 | Sale −$11,302 | not reported | Yes | Form 4 |
| White William Richard | Dec 2, 2024 | Dec 4, 2024 | M · derivative | 1,756 | $2.65 | $4,653 | not reported | Yes | Form 4 |
| White William Richard | Dec 2, 2024 | Dec 4, 2024 | M · derivative | 201 | $9.86 | $1,982 | 1,804 | Yes | Form 4 |
| Savage William JacobChief Medical Officer | Nov 25, 2024 | Nov 26, 2024 | M | 5,263 | $9.86 | $51,893 | 45,668 | Yes | Form 4 |
| Savage William JacobChief Medical Officer | Nov 25, 2024 | Nov 26, 2024 | M | 8,920 | $13.50 | $120,420 | 54,588 | Yes | Form 4 |
| Savage William JacobChief Medical Officer | Nov 25, 2024 | Nov 26, 2024 | S | 8,737 | $64.98 | Sale −$567,730 | 45,851 | Yes | Form 4 |
| Savage William JacobChief Medical Officer | Nov 25, 2024 | Nov 26, 2024 | S | 3,542 | $65.79 | Sale −$233,028 | 42,309 | Yes | Form 4 |
| Savage William JacobChief Medical Officer | Nov 25, 2024 | Nov 26, 2024 | S | 1,904 | $67.02 | Sale −$127,606 | 40,405 | Yes | Form 4 |
| Savage William JacobChief Medical Officer | Nov 25, 2024 | Nov 26, 2024 | M · derivative | 5,263 | $9.86 | $51,893 | 5,258 | Yes | Form 4 |
| Savage William JacobChief Medical Officer | Nov 25, 2024 | Nov 26, 2024 | M · derivative | 8,920 | $13.50 | $120,420 | 30,004 | Yes | Form 4 |
| Savage William JacobChief Medical Officer | Nov 15, 2024 | Nov 19, 2024 | M | 9,158 | $9.86 | $90,298 | 49,563 | Yes | Form 4 |
| Savage William JacobChief Medical Officer | Nov 15, 2024 | Nov 19, 2024 | S | 7,839 | $59.54 | Sale −$466,734 | 41,724 | Yes | Form 4 |
| Savage William JacobChief Medical Officer | Nov 15, 2024 | Nov 19, 2024 | S | 1,219 | $60.16 | Sale −$73,335 | 40,505 | Yes | Form 4 |
| Savage William JacobChief Medical Officer | Nov 15, 2024 | Nov 19, 2024 | S | 100 | $61.10 | Sale −$6,110 | 40,405 | Yes | Form 4 |
| Savage William JacobChief Medical Officer | Nov 15, 2024 | Nov 19, 2024 | M · derivative | 9,158 | $9.86 | $90,298 | 36,034 | Yes | Form 4 |
| White William Richard | Nov 4, 2024 | Nov 5, 2024 | M | 7,136 | $45.69 | $326,044 | 7,136 | Yes | Form 4 |
| White William Richard | Nov 4, 2024 | Nov 5, 2024 | S | 1,790 | $57.59 | Sale −$103,086 | 5,346 | Yes | Form 4 |
| White William Richard | Nov 4, 2024 | Nov 5, 2024 | S | 5,346 | $58.94 | Sale −$315,093 | not reported | Yes | Form 4 |
| White William Richard | Nov 4, 2024 | Nov 5, 2024 | M · derivative | 7,136 | $45.69 | $326,044 | not reported | Yes | Form 4 |
| White William Richard | Nov 1, 2024 | Nov 5, 2024 | M | 201 | $9.86 | $1,982 | 201 | Yes | Form 4 |
| White William Richard | Nov 1, 2024 | Nov 5, 2024 | S | 72 | $45.68 | Sale −$3,289 | 129 | Yes | Form 4 |
| White William Richard | Nov 1, 2024 | Nov 5, 2024 | S | 129 | $46.75 | Sale −$6,031 | not reported | Yes | Form 4 |
| White William Richard | Nov 1, 2024 | Nov 5, 2024 | M · derivative | 201 | $9.86 | $1,982 | 2,005 | Yes | Form 4 |
| White William Richard | Oct 1, 2024 | Oct 3, 2024 | M | 201 | $9.86 | $1,982 | 201 | Yes | Form 4 |
| White William Richard | Oct 1, 2024 | Oct 3, 2024 | S | 32 | $49.03 | Sale −$1,569 | 169 | Yes | Form 4 |
| White William Richard | Oct 1, 2024 | Oct 3, 2024 | S | 40 | $50.45 | Sale −$2,018 | 129 | Yes | Form 4 |
| White William Richard | Oct 1, 2024 | Oct 3, 2024 | S | 50 | $51.51 | Sale −$2,576 | 79 | Yes | Form 4 |
| White William Richard | Oct 1, 2024 | Oct 3, 2024 | S | 79 | $52.53 | Sale −$4,150 | not reported | Yes | Form 4 |
| White William Richard | Oct 1, 2024 | Oct 3, 2024 | M · derivative | 201 | $9.86 | $1,982 | 2,206 | Yes | Form 4 |
| Savage William JacobChief Medical Officer | Sep 16, 2024 | Sep 18, 2024 | S | 1,500 | $47.41 | Sale −$71,115 | 40,405 | Yes | Form 4 |
| White William Richard | Sep 3, 2024 | Sep 5, 2024 | M | 201 | $9.86 | $1,982 | 201 | Yes | Form 4 |
| White William Richard | Sep 3, 2024 | Sep 5, 2024 | M | 1,756 | $2.65 | $4,653 | 1,957 | Yes | Form 4 |
| White William Richard | Sep 3, 2024 | Sep 5, 2024 | S | 1,560 | $49.43 | Sale −$77,111 | 397 | Yes | Form 4 |
| White William Richard | Sep 3, 2024 | Sep 5, 2024 | S | 337 | $50.29 | Sale −$16,948 | 60 | Yes | Form 4 |
| White William Richard | Sep 3, 2024 | Sep 5, 2024 | S | 50 | $51.54 | Sale −$2,577 | 10 | Yes | Form 4 |
| White William Richard | Sep 3, 2024 | Sep 5, 2024 | S | 10 | $52.28 | Sale −$523 | not reported | Yes | Form 4 |
| White William Richard | Sep 3, 2024 | Sep 5, 2024 | M · derivative | 201 | $9.86 | $1,982 | 2,407 | Yes | Form 4 |
| White William Richard | Sep 3, 2024 | Sep 5, 2024 | M · derivative | 1,756 | $2.65 | $4,653 | 1,756 | Yes | Form 4 |
| Savage William JacobChief Medical Officer | Sep 3, 2024 | Sep 4, 2024 | S | 1,500 | $50.59 | Sale −$75,885 | 41,905 | Yes | Form 4 |
| White William Richard | Aug 1, 2024 | Aug 5, 2024 | M | 201 | $9.86 | $1,982 | 201 | Yes | Form 4 |
| White William Richard | Aug 1, 2024 | Aug 5, 2024 | S | 144 | $43.24 | Sale −$6,227 | 57 | Yes | Form 4 |
| White William Richard | Aug 1, 2024 | Aug 5, 2024 | S | 57 | $43.95 | Sale −$2,505 | not reported | Yes | Form 4 |
| White William Richard | Aug 1, 2024 | Aug 5, 2024 | M · derivative | 201 | $9.86 | $1,982 | 2,608 | Yes | Form 4 |
| Quisel John DChief Executive Officer | Jul 8, 2024 | Jul 10, 2024 | M | 3,000 | $1.01 | $3,030 | 72,065 | No | Form 4 |
| Quisel John DChief Executive Officer | Jul 8, 2024 | Jul 10, 2024 | M · derivative | 3,000 | $1.01 | $3,030 | 238,211 | No | Form 4 |
| White William Richard | Jul 1, 2024 | Jul 3, 2024 | M | 201 | $9.86 | $1,982 | 201 | Yes | Form 4 |
| White William Richard | Jul 1, 2024 | Jul 3, 2024 | S | 18 | $45.07 | Sale −$811 | 183 | Yes | Form 4 |
| White William Richard | Jul 1, 2024 | Jul 3, 2024 | S | 109 | $45.92 | Sale −$5,005 | 74 | Yes | Form 4 |
| White William Richard | Jul 1, 2024 | Jul 3, 2024 | S | 74 | $46.45 | Sale −$3,437 | not reported | Yes | Form 4 |
| White William Richard | Jul 1, 2024 | Jul 3, 2024 | M · derivative | 201 | $9.86 | $1,982 | 2,809 | Yes | Form 4 |
| OrbiMed Genesis GP LLC | Jun 17, 2024 | Jun 20, 2024 | P | 28,404 | $36.00 | Purchase +$1,022,544 | 608,611 | No | Form 4 |
| OrbiMed Genesis GP LLC | Jun 17, 2024 | Jun 20, 2024 | P | 43,944 | $36.00 | Purchase +$1,581,984 | 941,569 | No | Form 4 |
| OrbiMed Genesis GP LLC | Jun 17, 2024 | Jun 20, 2024 | P | 10,986 | $36.00 | Purchase +$395,496 | 235,391 | No | Form 4 |
| Ashiya Mona | Jun 17, 2024 | Jun 20, 2024 | P | 28,404 | $36.00 | Purchase +$1,022,544 | 608,611 | No | Form 4 |
| Ashiya Mona | Jun 17, 2024 | Jun 20, 2024 | P | 43,944 | $36.00 | Purchase +$1,581,984 | 941,569 | No | Form 4 |
| Ashiya Mona | Jun 17, 2024 | Jun 20, 2024 | P | 10,986 | $36.00 | Purchase +$395,496 | 235,391 | No | Form 4 |
| Access Industries Holdings LLC | Jun 17, 2024 | Jun 20, 2024 | A | 416,667 | $36.00 | $15,000,012 | 3,558,426 | No | Form 4 |
| Bitterman Kevin | Jun 17, 2024 | Jun 20, 2024 | P | 222,223 | $36.00 | Purchase +$8,000,028 | 420,549 | No | Form 4 |
| Ashiya Mona | Jun 12, 2024 | Jun 14, 2024 | A · derivative | 10,000 | $38.85 | $388,500 | 10,000 | No | Form 4 |
| Nicholson Donald William | Jun 12, 2024 | Jun 14, 2024 | A · derivative | 10,000 | $38.85 | $388,500 | 10,000 | No | Form 4 |
| Chin Mark | Jun 12, 2024 | Jun 14, 2024 | A · derivative | 10,000 | $38.85 | $388,500 | 10,000 | No | Form 4 |
| Ratcliffe Liam | Jun 12, 2024 | Jun 14, 2024 | A · derivative | 10,000 | $38.85 | $388,500 | 10,000 | No | Form 4 |
| Gemayel Georges | Jun 12, 2024 | Jun 14, 2024 | A · derivative | 10,000 | $38.85 | $388,500 | 10,000 | No | Form 4 |
| Bitterman Kevin | Jun 12, 2024 | Jun 14, 2024 | A · derivative | 10,000 | $38.85 | $388,500 | 10,000 | No | Form 4 |
| White William Richard | Jun 12, 2024 | Jun 14, 2024 | A · derivative | 10,000 | $38.85 | $388,500 | 10,000 | No | Form 4 |
| White William Richard | Jun 3, 2024 | Jun 5, 2024 | M | 1,756 | $2.65 | $4,653 | 1,756 | Yes | Form 4 |
| White William Richard | Jun 3, 2024 | Jun 5, 2024 | M | 201 | $9.86 | $1,982 | 1,957 | Yes | Form 4 |
| White William Richard | Jun 3, 2024 | Jun 5, 2024 | S | 107 | $35.15 | Sale −$3,761 | 1,850 | Yes | Form 4 |
| White William Richard | Jun 3, 2024 | Jun 5, 2024 | S | 1,755 | $36.10 | Sale −$63,356 | 95 | Yes | Form 4 |
| White William Richard | Jun 3, 2024 | Jun 5, 2024 | S | 95 | $36.72 | Sale −$3,488 | not reported | Yes | Form 4 |
| White William Richard | Jun 3, 2024 | Jun 5, 2024 | M · derivative | 1,756 | $2.65 | $4,653 | 3,512 | Yes | Form 4 |
| White William Richard | Jun 3, 2024 | Jun 5, 2024 | M · derivative | 201 | $9.86 | $1,982 | 3,010 | Yes | Form 4 |
| White William Richard | May 1, 2024 | May 3, 2024 | M | 201 | $9.86 | $1,982 | 201 | Yes | Form 4 |
| White William Richard | May 1, 2024 | May 3, 2024 | S | 162 | $28.52 | Sale −$4,620 | 39 | Yes | Form 4 |
| White William Richard | May 1, 2024 | May 3, 2024 | S | 39 | $29.11 | Sale −$1,135 | not reported | Yes | Form 4 |
| White William Richard | May 1, 2024 | May 3, 2024 | M · derivative | 201 | $9.86 | $1,982 | 3,211 | Yes | Form 4 |
| White William Richard | Apr 11, 2024 | Apr 15, 2024 | M | 1,756 | $2.65 | $4,653 | 1,756 | Yes | Form 4 |
| White William Richard | Apr 11, 2024 | Apr 15, 2024 | M | 804 | $9.86 | $7,927 | 2,560 | Yes | Form 4 |
| White William Richard | Apr 11, 2024 | Apr 15, 2024 | S | 2,482 | $31.79 | Sale −$78,903 | 78 | Yes | Form 4 |
| White William Richard | Apr 11, 2024 | Apr 15, 2024 | S | 78 | $32.18 | Sale −$2,510 | not reported | Yes | Form 4 |
| White William Richard | Apr 11, 2024 | Apr 15, 2024 | M · derivative | 1,756 | $2.65 | $4,653 | 5,268 | Yes | Form 4 |
| White William Richard | Apr 11, 2024 | Apr 15, 2024 | M · derivative | 804 | $9.86 | $7,927 | 3,412 | Yes | Form 4 |
| Savage William JacobChief Medical Officer | Apr 10, 2024 | Apr 11, 2024 | M | 21,870 | $2.65 | $57,956 | 43,405 | No | Form 4 |
| Savage William JacobChief Medical Officer | Apr 10, 2024 | Apr 11, 2024 | M · derivative | 13,093 | $2.65 | $34,696 | 4,233 | No | Form 4 |
| Savage William JacobChief Medical Officer | Apr 10, 2024 | Apr 11, 2024 | M · derivative | 8,777 | $2.65 | $23,259 | 1,498 | No | Form 4 |
| Bitterman Kevin | Mar 5, 2024 | Mar 7, 2024 | S | 26,157 | $73.50 | Sale −$1,922,540 | 677,503 | No | Form 4 |
| Savage William JacobChief Medical Officer | Jan 10, 2024 | Mar 1, 2024 | A | 18,535 | $0.00 | $0 | 21,535 | No | Form 4 |
| Savage William JacobChief Medical Officer | Jan 10, 2024 | Mar 1, 2024 | A · derivative | 27,800 | $63.90 | $1,776,420 | 27,800 | No | Form 4 |
| Yu Jonathan Yen-WenChief Business Officer | Jan 10, 2024 | Mar 1, 2024 | A | 18,165 | $0.00 | $0 | 18,165 | No | Form 4 |
| Yu Jonathan Yen-WenChief Business Officer | Jan 10, 2024 | Mar 1, 2024 | A · derivative | 27,250 | $63.90 | $1,741,275 | 27,250 | No | Form 4 |
| Khara RahulGeneral Counsel | Jan 10, 2024 | Mar 1, 2024 | A | 14,035 | $0.00 | $0 | 14,035 | No | Form 4 |
| Khara RahulGeneral Counsel | Jan 10, 2024 | Mar 1, 2024 | A · derivative | 21,050 | $63.90 | $1,345,095 | 21,050 | No | Form 4 |
| Quisel John DChief Executive Officer | Jan 10, 2024 | Mar 1, 2024 | A | 66,365 | $0.00 | $0 | 69,065 | No | Form 4 |
| Quisel John DChief Executive Officer | Jan 10, 2024 | Mar 1, 2024 | A · derivative | 99,550 | $63.90 | $6,361,245 | 99,550 | No | Form 4 |
| Bryce JoanneChief Financial Officer | Jan 10, 2024 | Mar 1, 2024 | A | 18,165 | $0.00 | $0 | 23,665 | No | Form 4 |
| Bryce JoanneChief Financial Officer | Jan 10, 2024 | Mar 1, 2024 | A · derivative | 27,250 | $63.90 | $1,741,275 | 27,250 | No | Form 4 |
| Stephenson PamelaChief Commercial Officer | Feb 26, 2024 | Feb 27, 2024 | A | 36,666 | $0.00 | $0 | 36,666 | No | Form 4 |
| Stephenson PamelaChief Commercial Officer | Feb 26, 2024 | Feb 27, 2024 | A · derivative | 55,000 | $64.66 | $3,556,300 | 55,000 | No | Form 4 |
| Franchi Jean M.Chief Financial Officer | Feb 7, 2024 | Feb 15, 2024 | A | 36,666 | $0.00 | $0 | 36,666 | No | Form 4 |
| Franchi Jean M.Chief Financial Officer | Feb 7, 2024 | Feb 15, 2024 | A · derivative | 55,000 | $65.25 | $3,588,750 | 55,000 | No | Form 4 |
| Atlas Venture Associates X, LLC | Jan 23, 2024 | Jan 25, 2024 | S | 47,500 | $67.65 | Sale −$3,213,375 | 1,402,186 | No | Form 4 |
| Atlas Venture Associates X, LLC | Jan 23, 2024 | Jan 25, 2024 | S | 82,500 | $67.65 | Sale −$5,581,125 | 703,660 | No | Form 4 |
| Atlas Venture Associates X, LLC | Jan 23, 2024 | Jan 25, 2024 | S | 20,000 | $67.65 | Sale −$1,353,000 | 198,326 | No | Form 4 |
| Bitterman Kevin | Jan 23, 2024 | Jan 25, 2024 | S | 82,500 | $67.65 | Sale −$5,581,125 | 703,660 | No | Form 4 |
| Bitterman Kevin | Jan 23, 2024 | Jan 25, 2024 | S | 20,000 | $67.65 | Sale −$1,353,000 | 198,326 | No | Form 4 |
| Atlas Venture Associates Opportunity I, L.P. | Jan 10, 2024 | Jan 12, 2024 | S | 30,000 | $64.00 | Sale −$1,920,000 | 1,449,686 | No | Form 4 |
| Atlas Venture Associates Opportunity I, L.P. | Jan 10, 2024 | Jan 12, 2024 | S | 20,000 | $64.00 | Sale −$1,280,000 | 786,160 | No | Form 4 |
| Bitterman Kevin | Jan 10, 2024 | Jan 12, 2024 | S | 20,000 | $64.00 | Sale −$1,280,000 | 786,160 | No | Form 4 |
| Quisel John DChief Executive Officer | Dec 29, 2023 | Jan 3, 2024 | M | 2,700 | $1.01 | $2,727 | 2,700 | No | Form 4 |
| Quisel John DChief Executive Officer | Dec 29, 2023 | Jan 3, 2024 | M · derivative | 2,700 | $1.01 | $2,727 | 241,211 | No | Form 4 |
| Bryce JoanneChief Financial Officer | Dec 27, 2023 | Dec 29, 2023 | M | 3,000 | $9.86 | $29,580 | 5,500 | No | Form 4 |
| Bryce JoanneChief Financial Officer | Dec 27, 2023 | Dec 29, 2023 | M · derivative | 3,000 | $9.86 | $29,580 | 73,745 | No | Form 4 |
| Ashiya Mona | Dec 18, 2023 | Dec 20, 2023 | M | 1,724 | $38.00 | $65,512 | 1,724 | No | Form 4 |
| Ashiya Mona | Dec 18, 2023 | Dec 20, 2023 | S | 1,724 | $59.24 | Sale −$102,130 | not reported | No | Form 4 |
| Ashiya Mona | Dec 18, 2023 | Dec 20, 2023 | M · derivative | 1,724 | $38.00 | $65,512 | not reported | No | Form 4 |
| OrbiMed Genesis GP LLC | Dec 18, 2023 | Dec 20, 2023 | M | 1,724 | $38.00 | $65,512 | 1,724 | No | Form 4 |
| OrbiMed Genesis GP LLC | Dec 18, 2023 | Dec 20, 2023 | S | 1,724 | $59.24 | Sale −$102,130 | not reported | No | Form 4 |
| OrbiMed Genesis GP LLC | Dec 18, 2023 | Dec 20, 2023 | M · derivative | 1,724 | $38.00 | $65,512 | not reported | No | Form 4 |
| OrbiMed Genesis GP LLC | Dec 14, 2023 | Dec 15, 2023 | S | 228,500 | $56.75 | Sale −$12,967,375 | 897,625 | No | Form 4 |
| OrbiMed Genesis GP LLC | Dec 14, 2023 | Dec 15, 2023 | S | 147,600 | $56.75 | Sale −$8,376,300 | 580,207 | No | Form 4 |
| OrbiMed Genesis GP LLC | Dec 14, 2023 | Dec 15, 2023 | S | 57,100 | $56.75 | Sale −$3,240,425 | 224,405 | No | Form 4 |
| Ashiya Mona | Dec 14, 2023 | Dec 15, 2023 | S | 228,500 | $56.75 | Sale −$12,967,375 | 897,625 | No | Form 4 |
| Ashiya Mona | Dec 14, 2023 | Dec 15, 2023 | S | 147,600 | $56.75 | Sale −$8,376,300 | 580,207 | No | Form 4 |
| Ashiya Mona | Dec 14, 2023 | Dec 15, 2023 | S | 57,100 | $56.75 | Sale −$3,240,425 | 224,405 | No | Form 4 |
| Ashiya Mona | Dec 14, 2023 | Dec 14, 2023 | S | 100 | $57.73 | Sale −$5,773 | 1,126,125 | No | Form 4 |
| Ashiya Mona | Dec 14, 2023 | Dec 14, 2023 | S | 100 | $57.73 | Sale −$5,773 | 727,807 | No | Form 4 |
| OrbiMed Genesis GP LLC | Dec 14, 2023 | Dec 14, 2023 | S | 100 | $57.73 | Sale −$5,773 | 1,126,125 | No | Form 4 |
| OrbiMed Genesis GP LLC | Dec 14, 2023 | Dec 14, 2023 | S | 100 | $57.73 | Sale −$5,773 | 727,807 | No | Form 4 |
| Atlas Venture Associates Opportunity I, LLC | Dec 14, 2023 | Dec 14, 2023 | S | 30,645 | $58.27 | Sale −$1,785,684 | 1,479,866 | No | Form 4 |
| Atlas Venture Associates Opportunity I, LLC | Dec 14, 2023 | Dec 14, 2023 | S | 20,429 | $58.27 | Sale −$1,190,398 | 806,280 | No | Form 4 |
| Atlas Venture Associates Opportunity I, LLC | Dec 14, 2023 | Dec 14, 2023 | S | 180 | $59.74 | Sale −$10,753 | 1,479,686 | No | Form 4 |
| Atlas Venture Associates Opportunity I, LLC | Dec 14, 2023 | Dec 14, 2023 | S | 120 | $59.74 | Sale −$7,169 | 806,160 | No | Form 4 |
| Bitterman Kevin | Dec 14, 2023 | Dec 14, 2023 | S | 20,429 | $58.27 | Sale −$1,190,398 | 806,280 | No | Form 4 |
| Bitterman Kevin | Dec 14, 2023 | Dec 14, 2023 | S | 120 | $59.74 | Sale −$7,169 | 806,160 | No | Form 4 |
| Ashiya Mona | Dec 13, 2023 | Dec 14, 2023 | S | 56,200 | $58.56 | Sale −$3,291,072 | 1,126,225 | No | Form 4 |
| Ashiya Mona | Dec 13, 2023 | Dec 14, 2023 | S | 36,400 | $58.56 | Sale −$2,131,584 | 727,907 | No | Form 4 |
| Ashiya Mona | Dec 13, 2023 | Dec 14, 2023 | S | 14,100 | $58.56 | Sale −$825,696 | 281,505 | No | Form 4 |
| OrbiMed Genesis GP LLC | Dec 13, 2023 | Dec 14, 2023 | S | 56,200 | $58.56 | Sale −$3,291,072 | 1,126,225 | No | Form 4 |
| OrbiMed Genesis GP LLC | Dec 13, 2023 | Dec 14, 2023 | S | 36,400 | $58.56 | Sale −$2,131,584 | 727,907 | No | Form 4 |
| OrbiMed Genesis GP LLC | Dec 13, 2023 | Dec 14, 2023 | S | 14,100 | $58.56 | Sale −$825,696 | 281,505 | No | Form 4 |
| Atlas Venture Associates Opportunity I, LLC | Dec 13, 2023 | Dec 14, 2023 | S | 5,263 | $59.99 | Sale −$315,727 | 1,510,571 | No | Form 4 |
| Atlas Venture Associates Opportunity I, LLC | Dec 13, 2023 | Dec 14, 2023 | S | 3,508 | $59.99 | Sale −$210,445 | 826,749 | No | Form 4 |
| Atlas Venture Associates Opportunity I, LLC | Dec 13, 2023 | Dec 14, 2023 | S | 60 | $60.50 | Sale −$3,630 | 1,510,511 | No | Form 4 |
| Atlas Venture Associates Opportunity I, LLC | Dec 13, 2023 | Dec 14, 2023 | S | 40 | $60.50 | Sale −$2,420 | 826,709 | No | Form 4 |
| Bitterman Kevin | Dec 13, 2023 | Dec 14, 2023 | S | 3,508 | $59.99 | Sale −$210,445 | 826,749 | No | Form 4 |
| Bitterman Kevin | Dec 13, 2023 | Dec 14, 2023 | S | 40 | $60.50 | Sale −$2,420 | 826,709 | No | Form 4 |
| Ashiya Mona | Dec 12, 2023 | Dec 14, 2023 | S | 14,400 | $60.16 | Sale −$866,304 | 1,182,425 | No | Form 4 |
| Ashiya Mona | Dec 12, 2023 | Dec 14, 2023 | S | 9,300 | $60.16 | Sale −$559,488 | 764,307 | No | Form 4 |
| Ashiya Mona | Dec 12, 2023 | Dec 14, 2023 | S | 3,600 | $60.16 | Sale −$216,576 | 295,605 | No | Form 4 |
| OrbiMed Genesis GP LLC | Dec 12, 2023 | Dec 14, 2023 | S | 14,400 | $60.16 | Sale −$866,304 | 1,182,425 | No | Form 4 |
| OrbiMed Genesis GP LLC | Dec 12, 2023 | Dec 14, 2023 | S | 9,300 | $60.16 | Sale −$559,488 | 764,307 | No | Form 4 |
| OrbiMed Genesis GP LLC | Dec 12, 2023 | Dec 14, 2023 | S | 3,600 | $60.16 | Sale −$216,576 | 295,605 | No | Form 4 |
| Bryce JoanneChief Financial Officer | Dec 12, 2023 | Dec 14, 2023 | M | 2,500 | $2.65 | $6,625 | 5,000 | Yes | Form 4 |
| Bryce JoanneChief Financial Officer | Dec 12, 2023 | Dec 14, 2023 | S | 2,500 | $65.22 | Sale −$163,050 | 2,500 | Yes | Form 4 |