KRYSKrystal Biotech, Inc.
- Market cap
- $9.22B
- as of 2026-10-23
- Latest close
- $311.50
- as of 2026-10-23
- Sector
- Healthcare
- as of 2026-10-24
- Industry
- Biotechnology
- as of 2026-10-24
Cluster
No cluster in the last 90 days under the default rule (14d · ≥2 insiders · all roles).
Form 4 historysince 2023-12-12
Showing the latest 500 of 535 transactions.
| Insider | Traded | Filed | Type | Shares | Price | Value | Owned after | 10b5-1 plan | Filing |
|---|---|---|---|---|---|---|---|---|---|
| Rossi Dino A | Sep 14 | Sep 16 | A · derivative | 1,187 | $340.03 | $403,616 | 1,187 | No | Form 4 |
| Rossi Dino A | Sep 14 | Sep 16 | A · derivative | 471 | $0.00 | $0 | 471 | No | Form 4 |
| Gangolli Julian S | Sep 14 | Sep 16 | A · derivative | 1,187 | $340.03 | $403,616 | 1,187 | No | Form 4 |
| Gangolli Julian S | Sep 14 | Sep 16 | A · derivative | 471 | $0.00 | $0 | 471 | No | Form 4 |
| Janney Daniel | Sep 14 | Sep 16 | A · derivative | 1,187 | $340.03 | $403,616 | 1,187 | No | Form 4 |
| Janney Daniel | Sep 14 | Sep 16 | A · derivative | 471 | $0.00 | $0 | 471 | No | Form 4 |
| Mason Christopher | Sep 14 | Sep 16 | A · derivative | 1,187 | $340.03 | $403,616 | 1,187 | No | Form 4 |
| Mason Christopher | Sep 14 | Sep 16 | A · derivative | 471 | $0.00 | $0 | 471 | No | Form 4 |
| Sutherland Everett Rand | Sep 14 | Sep 16 | A · derivative | 1,187 | $340.03 | $403,616 | 1,187 | No | Form 4 |
| Sutherland Everett Rand | Sep 14 | Sep 16 | A · derivative | 471 | $0.00 | $0 | 471 | No | Form 4 |
| Mazzacco Catherine | Sep 14 | Sep 16 | A · derivative | 1,187 | $340.03 | $403,616 | 1,187 | No | Form 4 |
| Mazzacco Catherine | Sep 14 | Sep 16 | A · derivative | 471 | $0.00 | $0 | 471 | No | Form 4 |
| Krishnan Krish SPresident and CEO | Sep 4 | Sep 4 | S | 520 | $354.54 | Sale −$184,361 | 1,372,023 | Yes | Form 4 |
| Krishnan Krish SPresident and CEO | Sep 4 | Sep 4 | S | 2,029 | $355.57 | Sale −$721,452 | 1,369,994 | Yes | Form 4 |
| Krishnan Krish SPresident and CEO | Sep 4 | Sep 4 | S | 3,297 | $356.37 | Sale −$1,174,952 | 1,366,697 | Yes | Form 4 |
| Krishnan Krish SPresident and CEO | Sep 4 | Sep 4 | S | 3,981 | $357.57 | Sale −$1,423,486 | 1,362,716 | Yes | Form 4 |
| Krishnan Krish SPresident and CEO | Sep 4 | Sep 4 | S | 3,143 | $358.42 | Sale −$1,126,514 | 1,359,573 | Yes | Form 4 |
| Krishnan Krish SPresident and CEO | Sep 4 | Sep 4 | S | 3,357 | $359.39 | Sale −$1,206,472 | 1,356,216 | Yes | Form 4 |
| Krishnan Krish SPresident and CEO | Sep 4 | Sep 4 | S | 2,266 | $360.46 | Sale −$816,802 | 1,353,950 | Yes | Form 4 |
| Krishnan Krish SPresident and CEO | Sep 4 | Sep 4 | S | 1,214 | $361.61 | Sale −$438,995 | 1,352,736 | Yes | Form 4 |
| Krishnan Krish SPresident and CEO | Sep 4 | Sep 4 | S | 2,010 | $362.65 | Sale −$728,927 | 1,350,726 | Yes | Form 4 |
| Krishnan Krish SPresident and CEO | Sep 4 | Sep 4 | S | 573 | $363.34 | Sale −$208,194 | 1,350,153 | Yes | Form 4 |
| Krishnan Krish SPresident and CEO | Sep 4 | Sep 4 | S | 1,358 | $364.48 | Sale −$494,964 | 1,348,795 | Yes | Form 4 |
| Krishnan Krish SPresident and CEO | Sep 4 | Sep 4 | S | 847 | $365.42 | Sale −$309,511 | 1,347,948 | Yes | Form 4 |
| Krishnan Krish SPresident and CEO | Sep 4 | Sep 4 | S | 405 | $366.56 | Sale −$148,457 | 1,347,543 | Yes | Form 4 |
| Krishnan SumaPresident, R&D | Sep 4 | Sep 4 | S | 520 | $354.54 | Sale −$184,361 | 1,326,625 | Yes | Form 4 |
| Krishnan SumaPresident, R&D | Sep 4 | Sep 4 | S | 2,006 | $355.57 | Sale −$713,273 | 1,324,619 | Yes | Form 4 |
| Krishnan SumaPresident, R&D | Sep 4 | Sep 4 | S | 3,267 | $356.37 | Sale −$1,164,261 | 1,321,352 | Yes | Form 4 |
| Krishnan SumaPresident, R&D | Sep 4 | Sep 4 | S | 3,962 | $357.57 | Sale −$1,416,692 | 1,317,390 | Yes | Form 4 |
| Krishnan SumaPresident, R&D | Sep 4 | Sep 4 | S | 3,180 | $358.42 | Sale −$1,139,776 | 1,314,210 | Yes | Form 4 |
| Krishnan SumaPresident, R&D | Sep 4 | Sep 4 | S | 3,392 | $359.39 | Sale −$1,219,051 | 1,310,818 | Yes | Form 4 |
| Krishnan SumaPresident, R&D | Sep 4 | Sep 4 | S | 2,320 | $360.47 | Sale −$836,290 | 1,308,498 | Yes | Form 4 |
| Krishnan SumaPresident, R&D | Sep 4 | Sep 4 | S | 1,242 | $361.61 | Sale −$449,120 | 1,307,256 | Yes | Form 4 |
| Krishnan SumaPresident, R&D | Sep 4 | Sep 4 | S | 1,992 | $362.65 | Sale −$722,399 | 1,305,264 | Yes | Form 4 |
| Krishnan SumaPresident, R&D | Sep 4 | Sep 4 | S | 565 | $363.34 | Sale −$205,287 | 1,304,699 | Yes | Form 4 |
| Krishnan SumaPresident, R&D | Sep 4 | Sep 4 | S | 1,329 | $364.48 | Sale −$484,394 | 1,303,370 | Yes | Form 4 |
| Krishnan SumaPresident, R&D | Sep 4 | Sep 4 | S | 826 | $365.41 | Sale −$301,829 | 1,302,544 | Yes | Form 4 |
| Krishnan SumaPresident, R&D | Sep 4 | Sep 4 | S | 399 | $366.56 | Sale −$146,257 | 1,302,145 | Yes | Form 4 |
| Rossi Dino A | Aug 14 | Aug 14 | G | 3,691 | $0.00 | $0 | 75,000 | No | Form 4 |
| Rossi Dino A | Aug 14 | Aug 14 | S | 341 | $325.60 | Sale −$111,030 | 74,659 | No | Form 4 |
| Rossi Dino A | Aug 14 | Aug 14 | S | 2,287 | $326.60 | Sale −$746,934 | 72,372 | No | Form 4 |
| Rossi Dino A | Aug 14 | Aug 14 | S | 5,226 | $327.39 | Sale −$1,710,940 | 67,146 | No | Form 4 |
| Rossi Dino A | Aug 14 | Aug 14 | S | 1,687 | $328.52 | Sale −$554,213 | 65,459 | No | Form 4 |
| Rossi Dino A | Aug 14 | Aug 14 | S | 7,428 | $329.60 | Sale −$2,448,269 | 58,031 | No | Form 4 |
| Rossi Dino A | Aug 14 | Aug 14 | S | 4,896 | $330.36 | Sale −$1,617,443 | 53,135 | No | Form 4 |
| Rossi Dino A | Aug 14 | Aug 14 | S | 3,095 | $331.43 | Sale −$1,025,776 | 50,040 | No | Form 4 |
| Rossi Dino A | Aug 14 | Aug 14 | S | 40 | $333.23 | Sale −$13,329 | 50,000 | No | Form 4 |
| Thomas John CharlesEVP, General Counsel | Jun 25 | Jun 26 | M | 1,000 | $179.25 | $179,250 | 1,000 | Yes | Form 4 |
| Thomas John CharlesEVP, General Counsel | Jun 25 | Jun 26 | S | 1,000 | $347.27 | Sale −$347,270 | not reported | Yes | Form 4 |
| Thomas John CharlesEVP, General Counsel | Jun 25 | Jun 26 | M · derivative | 1,000 | $179.25 | $179,250 | 6,500 | Yes | Form 4 |
| Krishnan Krish SPresident and CEO | Jun 4 | Jun 5 | S | 320 | $300.75 | Sale −$96,240 | 1,474,933 | Yes | Form 4 |
| Krishnan Krish SPresident and CEO | Jun 4 | Jun 5 | S | 640 | $302.24 | Sale −$193,434 | 1,474,293 | Yes | Form 4 |
| Krishnan Krish SPresident and CEO | Jun 4 | Jun 5 | S | 176 | $303.17 | Sale −$53,358 | 1,474,117 | Yes | Form 4 |
| Krishnan Krish SPresident and CEO | Jun 4 | Jun 5 | S | 544 | $304.81 | Sale −$165,817 | 1,473,573 | Yes | Form 4 |
| Krishnan Krish SPresident and CEO | Jun 4 | Jun 5 | S | 589 | $306.33 | Sale −$180,428 | 1,472,984 | Yes | Form 4 |
| Krishnan Krish SPresident and CEO | Jun 4 | Jun 5 | S | 11,461 | $307.68 | Sale −$3,526,320 | 1,461,523 | Yes | Form 4 |
| Krishnan Krish SPresident and CEO | Jun 4 | Jun 5 | S | 4,830 | $308.47 | Sale −$1,489,910 | 1,456,693 | Yes | Form 4 |
| Krishnan Krish SPresident and CEO | Jun 4 | Jun 5 | S | 2,784 | $309.49 | Sale −$861,620 | 1,453,909 | Yes | Form 4 |
| Krishnan Krish SPresident and CEO | Jun 4 | Jun 5 | S | 2,652 | $310.43 | Sale −$823,260 | 1,451,257 | Yes | Form 4 |
| Krishnan Krish SPresident and CEO | Jun 4 | Jun 5 | S | 964 | $311.36 | Sale −$300,151 | 1,450,293 | Yes | Form 4 |
| Krishnan Krish SPresident and CEO | Jun 4 | Jun 5 | S | 40 | $312.23 | Sale −$12,489 | 1,450,253 | Yes | Form 4 |
| Krishnan SumaPresident, R&D | Jun 4 | Jun 5 | S | 320 | $300.75 | Sale −$96,240 | 1,402,835 | Yes | Form 4 |
| Krishnan SumaPresident, R&D | Jun 4 | Jun 5 | S | 593 | $302.25 | Sale −$179,234 | 1,402,242 | Yes | Form 4 |
| Krishnan SumaPresident, R&D | Jun 4 | Jun 5 | S | 247 | $303.17 | Sale −$74,883 | 1,401,995 | Yes | Form 4 |
| Krishnan SumaPresident, R&D | Jun 4 | Jun 5 | S | 400 | $304.89 | Sale −$121,956 | 1,401,595 | Yes | Form 4 |
| Krishnan SumaPresident, R&D | Jun 4 | Jun 5 | S | 480 | $305.87 | Sale −$146,818 | 1,401,115 | Yes | Form 4 |
| Krishnan SumaPresident, R&D | Jun 4 | Jun 5 | S | 1,348 | $307.09 | Sale −$413,957 | 1,399,767 | Yes | Form 4 |
| Krishnan SumaPresident, R&D | Jun 4 | Jun 5 | S | 12,729 | $307.81 | Sale −$3,918,113 | 1,387,038 | Yes | Form 4 |
| Krishnan SumaPresident, R&D | Jun 4 | Jun 5 | S | 3,803 | $308.89 | Sale −$1,174,709 | 1,383,235 | Yes | Form 4 |
| Krishnan SumaPresident, R&D | Jun 4 | Jun 5 | S | 2,801 | $309.95 | Sale −$868,170 | 1,380,434 | Yes | Form 4 |
| Krishnan SumaPresident, R&D | Jun 4 | Jun 5 | S | 2,039 | $310.94 | Sale −$634,007 | 1,378,395 | Yes | Form 4 |
| Krishnan SumaPresident, R&D | Jun 4 | Jun 5 | S | 240 | $311.65 | Sale −$74,796 | 1,378,155 | Yes | Form 4 |
| Thomas John CharlesEVP, General Counsel | May 26 | May 27 | S | 642 | $302.03 | Sale −$193,903 | not reported | Yes | Form 4 |
| Krishnan Krish SPresident and CEO | Mar 4 | Mar 6 | S | 483 | $257.31 | Sale −$124,281 | 1,499,770 | Yes | Form 4 |
| Krishnan Krish SPresident and CEO | Mar 4 | Mar 6 | S | 470 | $258.38 | Sale −$121,439 | 1,499,300 | Yes | Form 4 |
| Krishnan Krish SPresident and CEO | Mar 4 | Mar 6 | S | 1,377 | $259.87 | Sale −$357,841 | 1,497,923 | Yes | Form 4 |
| Krishnan Krish SPresident and CEO | Mar 4 | Mar 6 | S | 3,128 | $260.49 | Sale −$814,813 | 1,494,795 | Yes | Form 4 |
| Krishnan Krish SPresident and CEO | Mar 4 | Mar 6 | S | 2,962 | $261.41 | Sale −$774,296 | 1,491,833 | Yes | Form 4 |
| Krishnan Krish SPresident and CEO | Mar 4 | Mar 6 | S | 2,380 | $262.44 | Sale −$624,607 | 1,489,453 | Yes | Form 4 |
| Krishnan Krish SPresident and CEO | Mar 4 | Mar 6 | S | 2,043 | $263.70 | Sale −$538,739 | 1,487,410 | Yes | Form 4 |
| Krishnan Krish SPresident and CEO | Mar 4 | Mar 6 | S | 8,798 | $264.85 | Sale −$2,330,150 | 1,478,612 | Yes | Form 4 |
| Krishnan Krish SPresident and CEO | Mar 4 | Mar 6 | S | 2,439 | $265.59 | Sale −$647,774 | 1,476,173 | Yes | Form 4 |
| Krishnan Krish SPresident and CEO | Mar 4 | Mar 6 | S | 920 | $266.56 | Sale −$245,235 | 1,475,253 | Yes | Form 4 |
| Krishnan SumaPresident, R&D | Mar 4 | Mar 6 | S | 407 | $257.32 | Sale −$104,729 | 1,427,748 | Yes | Form 4 |
| Krishnan SumaPresident, R&D | Mar 4 | Mar 6 | S | 589 | $258.54 | Sale −$152,280 | 1,427,159 | Yes | Form 4 |
| Krishnan SumaPresident, R&D | Mar 4 | Mar 6 | S | 668 | $259.61 | Sale −$173,419 | 1,426,491 | Yes | Form 4 |
| Krishnan SumaPresident, R&D | Mar 4 | Mar 6 | S | 3,667 | $260.37 | Sale −$954,777 | 1,422,824 | Yes | Form 4 |
| Krishnan SumaPresident, R&D | Mar 4 | Mar 6 | S | 2,931 | $261.41 | Sale −$766,193 | 1,419,893 | Yes | Form 4 |
| Krishnan SumaPresident, R&D | Mar 4 | Mar 6 | S | 1,938 | $262.35 | Sale −$508,434 | 1,417,955 | Yes | Form 4 |
| Krishnan SumaPresident, R&D | Mar 4 | Mar 6 | S | 2,248 | $263.58 | Sale −$592,528 | 1,415,707 | Yes | Form 4 |
| Krishnan SumaPresident, R&D | Mar 4 | Mar 6 | S | 4,852 | $264.64 | Sale −$1,284,033 | 1,410,855 | Yes | Form 4 |
| Krishnan SumaPresident, R&D | Mar 4 | Mar 6 | S | 6,000 | $265.16 | Sale −$1,590,960 | 1,404,855 | Yes | Form 4 |
| Krishnan SumaPresident, R&D | Mar 4 | Mar 6 | S | 1,700 | $266.42 | Sale −$452,914 | 1,403,155 | Yes | Form 4 |
| Romano KathrynChief Accounting Officer | Mar 2 | Mar 3 | S | 750 | $267.60 | Sale −$200,700 | 22,366 | Yes | Form 4 |
| Krishnan Krish SPresident and CEO | Feb 27 | Mar 3 | M | 8,750 | $0.00 | $0 | 1,486,806 | No | Form 4 |
| Krishnan Krish SPresident and CEO | Feb 27 | Mar 3 | F | 3,981 | $275.64 | $1,097,323 | 1,482,825 | No | Form 4 |
| Krishnan Krish SPresident and CEO | Feb 27 | Mar 3 | M | 26,250 | $0.00 | $0 | 1,509,075 | No | Form 4 |
| Krishnan Krish SPresident and CEO | Feb 27 | Mar 3 | F | 11,942 | $275.64 | $3,291,693 | 1,497,133 | No | Form 4 |
| Krishnan Krish SPresident and CEO | Feb 27 | Mar 3 | M | 5,725 | $0.00 | $0 | 1,502,858 | No | Form 4 |
| Krishnan Krish SPresident and CEO | Feb 27 | Mar 3 | F | 2,605 | $275.64 | $718,042 | 1,500,253 | No | Form 4 |
| Krishnan Krish SPresident and CEO | Feb 27 | Mar 3 | M | 22,500 | $0.00 | $0 | 1,436,211 | No | Form 4 |
| Krishnan Krish SPresident and CEO | Feb 27 | Mar 3 | F | 10,236 | $275.64 | $2,821,451 | 1,425,975 | No | Form 4 |
| Krishnan Krish SPresident and CEO | Feb 27 | Mar 3 | M | 4,000 | $0.00 | $0 | 1,429,975 | No | Form 4 |
| Krishnan Krish SPresident and CEO | Feb 27 | Mar 3 | F | 1,820 | $275.64 | $501,665 | 1,428,155 | No | Form 4 |
| Krishnan Krish SPresident and CEO | Feb 27 | Mar 3 | M · derivative | 8,750 | $0.00 | $0 | 17,500 | No | Form 4 |
| Krishnan Krish SPresident and CEO | Feb 27 | Mar 3 | M · derivative | 26,250 | $0.00 | $0 | not reported | No | Form 4 |
| Krishnan Krish SPresident and CEO | Feb 27 | Mar 3 | M · derivative | 5,725 | $0.00 | $0 | 17,175 | No | Form 4 |
| Krishnan Krish SPresident and CEO | Feb 27 | Mar 3 | A · derivative | 45,249 | $275.64 | $12,472,434 | 45,249 | No | Form 4 |
| Krishnan Krish SPresident and CEO | Feb 27 | Mar 3 | A · derivative | 18,140 | $0.00 | $0 | 18,140 | No | Form 4 |
| Krishnan SumaPresident, R&D | Feb 27 | Mar 3 | M | 22,500 | $0.00 | $0 | 1,436,211 | No | Form 4 |
| Krishnan SumaPresident, R&D | Feb 27 | Mar 3 | F | 10,236 | $275.64 | $2,821,451 | 1,425,975 | No | Form 4 |
| Krishnan SumaPresident, R&D | Feb 27 | Mar 3 | M | 4,000 | $0.00 | $0 | 1,429,975 | No | Form 4 |
| Krishnan SumaPresident, R&D | Feb 27 | Mar 3 | F | 1,820 | $275.64 | $501,665 | 1,428,155 | No | Form 4 |
| Krishnan SumaPresident, R&D | Feb 27 | Mar 3 | M | 8,750 | $0.00 | $0 | 1,486,806 | No | Form 4 |
| Krishnan SumaPresident, R&D | Feb 27 | Mar 3 | F | 3,981 | $275.64 | $1,097,323 | 1,482,825 | No | Form 4 |
| Krishnan SumaPresident, R&D | Feb 27 | Mar 3 | M | 26,250 | $0.00 | $0 | 1,509,075 | No | Form 4 |
| Krishnan SumaPresident, R&D | Feb 27 | Mar 3 | F | 11,942 | $275.64 | $3,291,693 | 1,497,133 | No | Form 4 |
| Krishnan SumaPresident, R&D | Feb 27 | Mar 3 | M | 5,725 | $0.00 | $0 | 1,502,858 | No | Form 4 |
| Krishnan SumaPresident, R&D | Feb 27 | Mar 3 | F | 2,605 | $275.64 | $718,042 | 1,500,253 | No | Form 4 |
| Krishnan SumaPresident, R&D | Feb 27 | Mar 3 | M · derivative | 22,500 | $0.00 | $0 | not reported | No | Form 4 |
| Krishnan SumaPresident, R&D | Feb 27 | Mar 3 | M · derivative | 4,000 | $0.00 | $0 | 12,000 | No | Form 4 |
| Krishnan SumaPresident, R&D | Feb 27 | Mar 3 | A · derivative | 18,100 | $275.64 | $4,989,084 | 18,100 | No | Form 4 |
| Krishnan SumaPresident, R&D | Feb 27 | Mar 3 | A · derivative | 7,256 | $0.00 | $0 | 7,256 | No | Form 4 |
| Krishnan SumaPresident, R&D | Feb 27 | Mar 3 | A · derivative | 43,536 | $0.00 | $0 | 43,536 | No | Form 4 |
| Janney Daniel | Feb 27 | Mar 3 | S | 9,430 | $275.45 | Sale −$2,597,494 | 75,666 | Yes | Form 4 |
| Janney Daniel | Feb 27 | Mar 3 | S | 2,373 | $276.17 | Sale −$655,351 | 73,293 | Yes | Form 4 |
| Romano KathrynChief Accounting Officer | Feb 27 | Mar 3 | M | 7,500 | $0.00 | $0 | 26,068 | Yes | Form 4 |
| Romano KathrynChief Accounting Officer | Feb 27 | Mar 3 | F | 3,262 | $275.64 | $899,138 | 22,806 | Yes | Form 4 |
| Romano KathrynChief Accounting Officer | Feb 27 | Mar 3 | M | 550 | $0.00 | $0 | 23,356 | Yes | Form 4 |
| Romano KathrynChief Accounting Officer | Feb 27 | Mar 3 | F | 240 | $275.64 | $66,154 | 23,116 | Yes | Form 4 |
| Romano KathrynChief Accounting Officer | Feb 27 | Mar 3 | M · derivative | 7,500 | $0.00 | $0 | not reported | Yes | Form 4 |
| Romano KathrynChief Accounting Officer | Feb 27 | Mar 3 | M · derivative | 550 | $0.00 | $0 | 1,650 | Yes | Form 4 |
| Romano KathrynChief Accounting Officer | Feb 27 | Mar 3 | A · derivative | 13,575 | $275.64 | $3,741,813 | 13,575 | Yes | Form 4 |
| Romano KathrynChief Accounting Officer | Feb 27 | Mar 3 | A · derivative | 5,442 | $0.00 | $0 | 5,442 | Yes | Form 4 |
| Janney Daniel | Feb 26 | Feb 26 | S | 5,103 | $275.28 | Sale −$1,404,754 | 87,734 | Yes | Form 4 |
| Janney Daniel | Feb 26 | Feb 26 | S | 2,638 | $276.32 | Sale −$728,932 | 85,096 | Yes | Form 4 |
| Janney Daniel | Feb 25 | Feb 26 | S | 700 | $275.00 | Sale −$192,500 | 92,837 | Yes | Form 4 |
| Janney Daniel | Feb 24 | Feb 26 | M | 37,895 | $2.46 | $93,222 | 37,895 | Yes | Form 4 |
| Janney Daniel | Feb 24 | Feb 26 | S | 569 | $262.91 | Sale −$149,596 | 37,326 | Yes | Form 4 |
| Janney Daniel | Feb 24 | Feb 26 | S | 1,733 | $264.12 | Sale −$457,720 | 35,593 | Yes | Form 4 |
| Janney Daniel | Feb 24 | Feb 26 | S | 3,557 | $265.08 | Sale −$942,890 | 32,036 | Yes | Form 4 |
| Janney Daniel | Feb 24 | Feb 26 | S | 8,986 | $266.18 | Sale −$2,391,893 | 23,050 | Yes | Form 4 |
| Janney Daniel | Feb 24 | Feb 26 | S | 11,673 | $266.97 | Sale −$3,116,341 | 11,377 | Yes | Form 4 |
| Janney Daniel | Feb 24 | Feb 26 | S | 6,671 | $268.04 | Sale −$1,788,095 | 4,706 | Yes | Form 4 |
| Janney Daniel | Feb 24 | Feb 26 | S | 3,963 | $268.97 | Sale −$1,065,928 | 743 | Yes | Form 4 |
| Janney Daniel | Feb 24 | Feb 26 | S | 370 | $269.83 | Sale −$99,837 | 373 | Yes | Form 4 |
| Janney Daniel | Feb 24 | Feb 26 | S | 373 | $271.09 | Sale −$101,117 | not reported | Yes | Form 4 |
| Janney Daniel | Feb 24 | Feb 26 | S | 62 | $263.05 | Sale −$16,309 | 107,300 | Yes | Form 4 |
| Janney Daniel | Feb 24 | Feb 26 | S | 900 | $264.60 | Sale −$238,140 | 106,400 | Yes | Form 4 |
| Janney Daniel | Feb 24 | Feb 26 | S | 1,604 | $265.54 | Sale −$425,926 | 104,796 | Yes | Form 4 |
| Janney Daniel | Feb 24 | Feb 26 | S | 4,339 | $266.62 | Sale −$1,156,864 | 100,457 | Yes | Form 4 |
| Janney Daniel | Feb 24 | Feb 26 | S | 1,891 | $267.37 | Sale −$505,597 | 98,566 | Yes | Form 4 |
| Janney Daniel | Feb 24 | Feb 26 | S | 1,674 | $268.67 | Sale −$449,754 | 96,892 | Yes | Form 4 |
| Janney Daniel | Feb 24 | Feb 26 | S | 930 | $269.50 | Sale −$250,635 | 95,962 | Yes | Form 4 |
| Janney Daniel | Feb 24 | Feb 26 | S | 2,425 | $274.90 | Sale −$666,633 | 93,537 | Yes | Form 4 |
| Janney Daniel | Feb 24 | Feb 26 | M · derivative | 37,895 | $2.46 | $93,222 | not reported | Yes | Form 4 |
| Rossi Dino A | Feb 19 | Feb 23 | M | 18,950 | $8.79 | $166,571 | 97,641 | No | Form 4 |
| Rossi Dino A | Feb 19 | Feb 23 | S | 8,116 | $260.49 | Sale −$2,114,137 | 89,525 | No | Form 4 |
| Rossi Dino A | Feb 19 | Feb 23 | S | 10,834 | $262.10 | Sale −$2,839,591 | 78,691 | No | Form 4 |
| Rossi Dino A | Feb 19 | Feb 23 | M · derivative | 18,950 | $8.79 | $166,571 | not reported | No | Form 4 |
| Romano KathrynChief Accounting Officer | Feb 9 | Feb 11 | M | 12,500 | $63.55 | $794,375 | 31,818 | Yes | Form 4 |
| Romano KathrynChief Accounting Officer | Feb 9 | Feb 11 | S | 2,000 | $270.56 | Sale −$541,120 | 29,818 | Yes | Form 4 |
| Romano KathrynChief Accounting Officer | Feb 9 | Feb 11 | S | 5,700 | $271.66 | Sale −$1,548,462 | 24,118 | Yes | Form 4 |
| Romano KathrynChief Accounting Officer | Feb 9 | Feb 11 | S | 2,824 | $272.51 | Sale −$769,568 | 21,294 | Yes | Form 4 |
| Romano KathrynChief Accounting Officer | Feb 9 | Feb 11 | S | 928 | $273.71 | Sale −$254,003 | 20,366 | Yes | Form 4 |
| Romano KathrynChief Accounting Officer | Feb 9 | Feb 11 | S | 552 | $274.64 | Sale −$151,601 | 19,814 | Yes | Form 4 |
| Romano KathrynChief Accounting Officer | Feb 9 | Feb 11 | S | 400 | $275.68 | Sale −$110,272 | 19,414 | Yes | Form 4 |
| Romano KathrynChief Accounting Officer | Feb 9 | Feb 11 | S | 96 | $277.88 | Sale −$26,676 | 19,318 | Yes | Form 4 |
| Romano KathrynChief Accounting Officer | Feb 9 | Feb 11 | G | 750 | $0.00 | $0 | 18,568 | Yes | Form 4 |
| Romano KathrynChief Accounting Officer | Feb 9 | Feb 11 | M · derivative | 12,500 | $63.55 | $794,375 | 12,500 | Yes | Form 4 |
| Krishnan Krish SPresident and CEO | Dec 5, 2025 | Dec 5, 2025 | G | 5,000 | $0.00 | $0 | 1,478,056 | Yes | Form 4 |
| Krishnan SumaPresident, R&D | Dec 5, 2025 | Dec 5, 2025 | G | 5,000 | $0.00 | $0 | 1,478,056 | Yes | Form 4 |
| Krishnan Krish SPresident and CEO | Dec 4, 2025 | Dec 5, 2025 | S | 956 | $214.28 | Sale −$204,852 | 1,507,100 | Yes | Form 4 |
| Krishnan Krish SPresident and CEO | Dec 4, 2025 | Dec 5, 2025 | S | 344 | $215.48 | Sale −$74,125 | 1,506,756 | Yes | Form 4 |
| Krishnan Krish SPresident and CEO | Dec 4, 2025 | Dec 5, 2025 | S | 1,600 | $217.04 | Sale −$347,264 | 1,505,156 | Yes | Form 4 |
| Krishnan Krish SPresident and CEO | Dec 4, 2025 | Dec 5, 2025 | S | 2,577 | $218.72 | Sale −$563,641 | 1,502,579 | Yes | Form 4 |
| Krishnan Krish SPresident and CEO | Dec 4, 2025 | Dec 5, 2025 | S | 5,693 | $219.55 | Sale −$1,249,898 | 1,496,886 | Yes | Form 4 |
| Krishnan Krish SPresident and CEO | Dec 4, 2025 | Dec 5, 2025 | S | 2,625 | $220.34 | Sale −$578,393 | 1,494,261 | Yes | Form 4 |
| Krishnan Krish SPresident and CEO | Dec 4, 2025 | Dec 5, 2025 | S | 10,505 | $221.78 | Sale −$2,329,799 | 1,483,756 | Yes | Form 4 |
| Krishnan Krish SPresident and CEO | Dec 4, 2025 | Dec 5, 2025 | S | 700 | $222.20 | Sale −$155,540 | 1,483,056 | Yes | Form 4 |
| Krishnan Krish SPresident and CEO | Dec 4, 2025 | Dec 5, 2025 | S | 700 | $214.25 | Sale −$149,975 | 1,438,011 | Yes | Form 4 |
| Krishnan Krish SPresident and CEO | Dec 4, 2025 | Dec 5, 2025 | S | 600 | $215.49 | Sale −$129,294 | 1,437,411 | Yes | Form 4 |
| Krishnan Krish SPresident and CEO | Dec 4, 2025 | Dec 5, 2025 | S | 1,400 | $216.97 | Sale −$303,758 | 1,436,011 | Yes | Form 4 |
| Krishnan Krish SPresident and CEO | Dec 4, 2025 | Dec 5, 2025 | S | 3,593 | $218.83 | Sale −$786,256 | 1,432,418 | Yes | Form 4 |
| Krishnan Krish SPresident and CEO | Dec 4, 2025 | Dec 5, 2025 | S | 5,419 | $219.68 | Sale −$1,190,446 | 1,426,999 | Yes | Form 4 |
| Krishnan Krish SPresident and CEO | Dec 4, 2025 | Dec 5, 2025 | S | 2,627 | $220.52 | Sale −$579,306 | 1,424,372 | Yes | Form 4 |
| Krishnan Krish SPresident and CEO | Dec 4, 2025 | Dec 5, 2025 | S | 10,461 | $221.82 | Sale −$2,320,459 | 1,413,911 | Yes | Form 4 |
| Krishnan Krish SPresident and CEO | Dec 4, 2025 | Dec 5, 2025 | S | 200 | $222.38 | Sale −$44,476 | 1,413,711 | Yes | Form 4 |
| Krishnan SumaPresident, R&D | Dec 4, 2025 | Dec 5, 2025 | S | 700 | $214.25 | Sale −$149,975 | 1,438,011 | Yes | Form 4 |
| Krishnan SumaPresident, R&D | Dec 4, 2025 | Dec 5, 2025 | S | 600 | $215.49 | Sale −$129,294 | 1,437,411 | Yes | Form 4 |
| Krishnan SumaPresident, R&D | Dec 4, 2025 | Dec 5, 2025 | S | 1,400 | $216.97 | Sale −$303,758 | 1,436,011 | Yes | Form 4 |
| Krishnan SumaPresident, R&D | Dec 4, 2025 | Dec 5, 2025 | S | 3,593 | $218.83 | Sale −$786,256 | 1,432,418 | Yes | Form 4 |
| Krishnan SumaPresident, R&D | Dec 4, 2025 | Dec 5, 2025 | S | 5,419 | $219.68 | Sale −$1,190,446 | 1,426,999 | Yes | Form 4 |
| Krishnan SumaPresident, R&D | Dec 4, 2025 | Dec 5, 2025 | S | 2,627 | $220.52 | Sale −$579,306 | 1,424,372 | Yes | Form 4 |
| Krishnan SumaPresident, R&D | Dec 4, 2025 | Dec 5, 2025 | S | 10,461 | $221.82 | Sale −$2,320,459 | 1,413,911 | Yes | Form 4 |
| Krishnan SumaPresident, R&D | Dec 4, 2025 | Dec 5, 2025 | S | 200 | $222.38 | Sale −$44,476 | 1,413,711 | Yes | Form 4 |
| Krishnan SumaPresident, R&D | Dec 4, 2025 | Dec 5, 2025 | S | 956 | $214.28 | Sale −$204,852 | 1,507,100 | Yes | Form 4 |
| Krishnan SumaPresident, R&D | Dec 4, 2025 | Dec 5, 2025 | S | 344 | $215.48 | Sale −$74,125 | 1,506,756 | Yes | Form 4 |
| Krishnan SumaPresident, R&D | Dec 4, 2025 | Dec 5, 2025 | S | 1,600 | $217.04 | Sale −$347,264 | 1,505,156 | Yes | Form 4 |
| Krishnan SumaPresident, R&D | Dec 4, 2025 | Dec 5, 2025 | S | 2,577 | $218.72 | Sale −$563,641 | 1,502,579 | Yes | Form 4 |
| Krishnan SumaPresident, R&D | Dec 4, 2025 | Dec 5, 2025 | S | 5,693 | $219.53 | Sale −$1,249,784 | 1,496,886 | Yes | Form 4 |
| Krishnan SumaPresident, R&D | Dec 4, 2025 | Dec 5, 2025 | S | 2,625 | $220.34 | Sale −$578,393 | 1,494,261 | Yes | Form 4 |
| Krishnan SumaPresident, R&D | Dec 4, 2025 | Dec 5, 2025 | S | 10,505 | $221.78 | Sale −$2,329,799 | 1,483,756 | Yes | Form 4 |
| Krishnan SumaPresident, R&D | Dec 4, 2025 | Dec 5, 2025 | S | 700 | $222.20 | Sale −$155,540 | 1,483,056 | Yes | Form 4 |
| Krishnan Krish SPresident and CEO | Jul 16, 2025 | Jul 16, 2025 | S | 1,389 | $150.00 | Sale −$208,350 | 1,508,056 | Yes | Form 4 |
| Krishnan Krish SPresident and CEO | Jul 16, 2025 | Jul 16, 2025 | S | 1,529 | $150.00 | Sale −$229,350 | 1,438,711 | Yes | Form 4 |
| Krishnan SumaPresident, R&D | Jul 16, 2025 | Jul 16, 2025 | S | 1,529 | $150.00 | Sale −$229,350 | 1,438,711 | Yes | Form 4 |
| Krishnan SumaPresident, R&D | Jul 16, 2025 | Jul 16, 2025 | S | 1,389 | $150.00 | Sale −$208,350 | 1,508,056 | Yes | Form 4 |
| Krishnan Krish SPresident and CEO | Jul 15, 2025 | Jul 16, 2025 | S | 2,184 | $150.68 | Sale −$329,085 | 1,510,345 | Yes | Form 4 |
| Krishnan Krish SPresident and CEO | Jul 15, 2025 | Jul 16, 2025 | S | 900 | $151.79 | Sale −$136,611 | 1,509,445 | Yes | Form 4 |
| Krishnan Krish SPresident and CEO | Jul 15, 2025 | Jul 16, 2025 | S | 2,236 | $150.68 | Sale −$336,920 | 1,441,040 | Yes | Form 4 |
| Krishnan Krish SPresident and CEO | Jul 15, 2025 | Jul 16, 2025 | S | 800 | $151.79 | Sale −$121,432 | 1,440,240 | Yes | Form 4 |
| Krishnan SumaPresident, R&D | Jul 15, 2025 | Jul 16, 2025 | S | 2,236 | $150.68 | Sale −$336,920 | 1,441,040 | Yes | Form 4 |
| Krishnan SumaPresident, R&D | Jul 15, 2025 | Jul 16, 2025 | S | 800 | $151.79 | Sale −$121,432 | 1,440,240 | Yes | Form 4 |
| Krishnan SumaPresident, R&D | Jul 15, 2025 | Jul 16, 2025 | S | 2,184 | $150.68 | Sale −$329,085 | 1,510,345 | Yes | Form 4 |
| Krishnan SumaPresident, R&D | Jul 15, 2025 | Jul 16, 2025 | S | 900 | $151.79 | Sale −$136,611 | 1,509,445 | Yes | Form 4 |
| Krishnan Krish SPresident and CEO | Jul 14, 2025 | Jul 16, 2025 | S | 13,400 | $150.30 | Sale −$2,014,020 | 1,512,529 | Yes | Form 4 |
| Krishnan Krish SPresident and CEO | Jul 14, 2025 | Jul 16, 2025 | S | 13,335 | $150.29 | Sale −$2,004,117 | 1,443,376 | Yes | Form 4 |
| Krishnan Krish SPresident and CEO | Jul 14, 2025 | Jul 16, 2025 | S | 100 | $151.00 | Sale −$15,100 | 1,443,276 | Yes | Form 4 |
| Krishnan SumaPresident, R&D | Jul 14, 2025 | Jul 16, 2025 | S | 13,335 | $150.29 | Sale −$2,004,117 | 1,443,376 | Yes | Form 4 |
| Krishnan SumaPresident, R&D | Jul 14, 2025 | Jul 16, 2025 | S | 100 | $151.00 | Sale −$15,100 | 1,443,276 | Yes | Form 4 |
| Krishnan SumaPresident, R&D | Jul 14, 2025 | Jul 16, 2025 | S | 13,400 | $150.30 | Sale −$2,014,020 | 1,512,529 | Yes | Form 4 |
| Krishnan Krish SPresident and CEO | Jul 10, 2025 | Jul 11, 2025 | S | 6,627 | $150.22 | Sale −$995,508 | 1,526,229 | Yes | Form 4 |
| Krishnan Krish SPresident and CEO | Jul 10, 2025 | Jul 11, 2025 | S | 300 | $151.39 | Sale −$45,417 | 1,525,929 | Yes | Form 4 |
| Krishnan Krish SPresident and CEO | Jul 10, 2025 | Jul 11, 2025 | S | 6,500 | $150.23 | Sale −$976,495 | 1,457,011 | Yes | Form 4 |
| Krishnan Krish SPresident and CEO | Jul 10, 2025 | Jul 11, 2025 | S | 300 | $151.39 | Sale −$45,417 | 1,456,711 | Yes | Form 4 |
| Krishnan SumaPresident, R&D | Jul 10, 2025 | Jul 11, 2025 | S | 6,500 | $150.23 | Sale −$976,495 | 1,457,011 | Yes | Form 4 |
| Krishnan SumaPresident, R&D | Jul 10, 2025 | Jul 11, 2025 | S | 300 | $151.39 | Sale −$45,417 | 1,456,711 | Yes | Form 4 |
| Krishnan SumaPresident, R&D | Jul 10, 2025 | Jul 11, 2025 | S | 6,627 | $150.22 | Sale −$995,508 | 1,526,229 | Yes | Form 4 |
| Krishnan SumaPresident, R&D | Jul 10, 2025 | Jul 11, 2025 | S | 300 | $151.39 | Sale −$45,417 | 1,525,929 | Yes | Form 4 |
| Krishnan Krish SPresident and CEO | Jul 9, 2025 | Jul 11, 2025 | S | 200 | $150.07 | Sale −$30,014 | 1,532,856 | Yes | Form 4 |
| Krishnan Krish SPresident and CEO | Jul 9, 2025 | Jul 11, 2025 | S | 200 | $150.14 | Sale −$30,028 | 1,463,511 | Yes | Form 4 |
| Krishnan SumaPresident, R&D | Jul 9, 2025 | Jul 11, 2025 | S | 200 | $150.14 | Sale −$30,028 | 1,463,511 | Yes | Form 4 |
| Krishnan SumaPresident, R&D | Jul 9, 2025 | Jul 11, 2025 | S | 200 | $150.07 | Sale −$30,014 | 1,532,856 | Yes | Form 4 |
| Rossi Dino A | Jun 30, 2025 | Jun 30, 2025 | A · derivative | 5,000 | $137.46 | $687,300 | 5,000 | No | Form 4 |
| Gangolli Julian S | Jun 30, 2025 | Jun 30, 2025 | A · derivative | 5,000 | $137.46 | $687,300 | 5,000 | No | Form 4 |
| Janney Daniel | Jun 30, 2025 | Jun 30, 2025 | A · derivative | 5,000 | $137.46 | $687,300 | 5,000 | No | Form 4 |
| Mason Christopher | Jun 30, 2025 | Jun 30, 2025 | A · derivative | 5,000 | $137.46 | $687,300 | 5,000 | No | Form 4 |
| Sutherland Everett Rand | Jun 30, 2025 | Jun 30, 2025 | A · derivative | 5,000 | $137.46 | $687,300 | 5,000 | No | Form 4 |
| Mazzacco Catherine | Jun 30, 2025 | Jun 30, 2025 | A · derivative | 5,000 | $137.46 | $687,300 | 5,000 | No | Form 4 |
| Krishnan Krish SPresident and CEO | Mar 13, 2025 | Mar 13, 2025 | S | 1,100 | $175.83 | Sale −$193,413 | 1,556,956 | Yes | Form 4 |
| Krishnan Krish SPresident and CEO | Mar 13, 2025 | Mar 13, 2025 | S | 4,944 | $176.80 | Sale −$874,099 | 1,552,012 | Yes | Form 4 |
| Krishnan Krish SPresident and CEO | Mar 13, 2025 | Mar 13, 2025 | S | 10,931 | $177.62 | Sale −$1,941,564 | 1,541,081 | Yes | Form 4 |
| Krishnan Krish SPresident and CEO | Mar 13, 2025 | Mar 13, 2025 | S | 6,769 | $178.77 | Sale −$1,210,094 | 1,534,312 | Yes | Form 4 |
| Krishnan Krish SPresident and CEO | Mar 13, 2025 | Mar 13, 2025 | S | 1,256 | $179.57 | Sale −$225,540 | 1,533,056 | Yes | Form 4 |
| Krishnan Krish SPresident and CEO | Mar 13, 2025 | Mar 13, 2025 | S | 1,639 | $175.97 | Sale −$288,415 | 1,487,072 | Yes | Form 4 |
| Krishnan Krish SPresident and CEO | Mar 13, 2025 | Mar 13, 2025 | S | 4,579 | $176.88 | Sale −$809,934 | 1,482,493 | Yes | Form 4 |
| Krishnan Krish SPresident and CEO | Mar 13, 2025 | Mar 13, 2025 | S | 10,937 | $177.66 | Sale −$1,943,067 | 1,471,556 | Yes | Form 4 |
| Krishnan Krish SPresident and CEO | Mar 13, 2025 | Mar 13, 2025 | S | 6,514 | $178.76 | Sale −$1,164,443 | 1,465,042 | Yes | Form 4 |
| Krishnan Krish SPresident and CEO | Mar 13, 2025 | Mar 13, 2025 | S | 1,331 | $179.55 | Sale −$238,981 | 1,463,711 | Yes | Form 4 |
| Krishnan SumaPresident, R&D | Mar 13, 2025 | Mar 13, 2025 | S | 1,639 | $175.97 | Sale −$288,415 | 1,487,072 | Yes | Form 4 |
| Krishnan SumaPresident, R&D | Mar 13, 2025 | Mar 13, 2025 | S | 4,579 | $176.88 | Sale −$809,934 | 1,482,493 | Yes | Form 4 |
| Krishnan SumaPresident, R&D | Mar 13, 2025 | Mar 13, 2025 | S | 10,937 | $177.66 | Sale −$1,943,067 | 1,471,556 | Yes | Form 4 |
| Krishnan SumaPresident, R&D | Mar 13, 2025 | Mar 13, 2025 | S | 6,514 | $178.76 | Sale −$1,164,443 | 1,465,042 | Yes | Form 4 |
| Krishnan SumaPresident, R&D | Mar 13, 2025 | Mar 13, 2025 | S | 1,331 | $179.55 | Sale −$238,981 | 1,463,711 | Yes | Form 4 |
| Krishnan SumaPresident, R&D | Mar 13, 2025 | Mar 13, 2025 | S | 1,100 | $175.83 | Sale −$193,413 | 1,556,956 | Yes | Form 4 |
| Krishnan SumaPresident, R&D | Mar 13, 2025 | Mar 13, 2025 | S | 4,944 | $176.80 | Sale −$874,099 | 1,552,012 | Yes | Form 4 |
| Krishnan SumaPresident, R&D | Mar 13, 2025 | Mar 13, 2025 | S | 10,931 | $177.62 | Sale −$1,941,564 | 1,541,081 | Yes | Form 4 |
| Krishnan SumaPresident, R&D | Mar 13, 2025 | Mar 13, 2025 | S | 6,769 | $178.77 | Sale −$1,210,094 | 1,534,312 | Yes | Form 4 |
| Krishnan SumaPresident, R&D | Mar 13, 2025 | Mar 13, 2025 | S | 1,256 | $179.57 | Sale −$225,540 | 1,533,056 | Yes | Form 4 |
| Krishnan Krish SPresident and CEO | Feb 28, 2025 | Feb 28, 2025 | M | 12,500 | $0.00 | $0 | 1,545,041 | No | Form 4 |
| Krishnan Krish SPresident and CEO | Feb 28, 2025 | Feb 28, 2025 | F | 5,786 | $179.25 | $1,037,141 | 1,539,255 | No | Form 4 |
| Krishnan Krish SPresident and CEO | Feb 28, 2025 | Feb 28, 2025 | M | 8,750 | $0.00 | $0 | 1,548,005 | No | Form 4 |
| Krishnan Krish SPresident and CEO | Feb 28, 2025 | Feb 28, 2025 | F | 4,050 | $179.25 | $725,963 | 1,543,955 | No | Form 4 |
| Krishnan Krish SPresident and CEO | Feb 28, 2025 | Feb 28, 2025 | M | 26,250 | $0.00 | $0 | 1,570,205 | No | Form 4 |
| Krishnan Krish SPresident and CEO | Feb 28, 2025 | Feb 28, 2025 | F | 12,149 | $179.25 | $2,177,708 | 1,558,056 | No | Form 4 |
| Krishnan Krish SPresident and CEO | Feb 28, 2025 | Feb 28, 2025 | M | 7,500 | $0.00 | $0 | 1,483,382 | No | Form 4 |
| Krishnan Krish SPresident and CEO | Feb 28, 2025 | Feb 28, 2025 | F | 3,471 | $179.25 | $622,177 | 1,479,911 | No | Form 4 |
| Krishnan Krish SPresident and CEO | Feb 28, 2025 | Feb 28, 2025 | M | 22,500 | $0.00 | $0 | 1,502,411 | No | Form 4 |
| Krishnan Krish SPresident and CEO | Feb 28, 2025 | Feb 28, 2025 | F | 10,414 | $179.25 | $1,866,710 | 1,491,997 | No | Form 4 |
| Krishnan Krish SPresident and CEO | Feb 28, 2025 | Feb 28, 2025 | M · derivative | 12,500 | $0.00 | $0 | not reported | No | Form 4 |
| Krishnan Krish SPresident and CEO | Feb 28, 2025 | Feb 28, 2025 | M · derivative | 8,750 | $0.00 | $0 | 26,250 | No | Form 4 |
| Krishnan Krish SPresident and CEO | Feb 28, 2025 | Feb 28, 2025 | M · derivative | 26,250 | $0.00 | $0 | 26,250 | No | Form 4 |
| Krishnan Krish SPresident and CEO | Feb 28, 2025 | Feb 28, 2025 | A · derivative | 39,300 | $179.25 | $7,044,525 | 39,300 | No | Form 4 |
| Krishnan Krish SPresident and CEO | Feb 28, 2025 | Feb 28, 2025 | A · derivative | 22,900 | $0.00 | $0 | 22,900 | No | Form 4 |
| Krishnan SumaPresident, R&D | Feb 28, 2025 | Feb 28, 2025 | M | 7,500 | $0.00 | $0 | 1,480,096 | No | Form 4 |
| Krishnan SumaPresident, R&D | Feb 28, 2025 | Feb 28, 2025 | F | 3,471 | $179.25 | $622,177 | 1,476,625 | No | Form 4 |
| Krishnan SumaPresident, R&D | Feb 28, 2025 | Feb 28, 2025 | M | 22,500 | $0.00 | $0 | 1,499,125 | No | Form 4 |
| Krishnan SumaPresident, R&D | Feb 28, 2025 | Feb 28, 2025 | F | 10,414 | $179.25 | $1,866,710 | 1,488,711 | No | Form 4 |
| Krishnan SumaPresident, R&D | Feb 28, 2025 | Feb 28, 2025 | M | 12,500 | $0.00 | $0 | 1,549,762 | No | Form 4 |
| Krishnan SumaPresident, R&D | Feb 28, 2025 | Feb 28, 2025 | F | 5,786 | $179.25 | $1,037,141 | 1,543,976 | No | Form 4 |
| Krishnan SumaPresident, R&D | Feb 28, 2025 | Feb 28, 2025 | M | 8,750 | $0.00 | $0 | 1,552,726 | No | Form 4 |
| Krishnan SumaPresident, R&D | Feb 28, 2025 | Feb 28, 2025 | F | 4,050 | $179.25 | $725,963 | 1,548,676 | No | Form 4 |
| Krishnan SumaPresident, R&D | Feb 28, 2025 | Feb 28, 2025 | M | 26,250 | $0.00 | $0 | 1,574,926 | No | Form 4 |
| Krishnan SumaPresident, R&D | Feb 28, 2025 | Feb 28, 2025 | F | 12,149 | $179.25 | $2,177,708 | 1,562,777 | No | Form 4 |
| Krishnan SumaPresident, R&D | Feb 28, 2025 | Feb 28, 2025 | M · derivative | 7,500 | $0.00 | $0 | not reported | No | Form 4 |
| Krishnan SumaPresident, R&D | Feb 28, 2025 | Feb 28, 2025 | M · derivative | 22,500 | $0.00 | $0 | 22,500 | No | Form 4 |
| Krishnan SumaPresident, R&D | Feb 28, 2025 | Feb 28, 2025 | A · derivative | 25,000 | $179.25 | $4,481,250 | 25,000 | No | Form 4 |
| Krishnan SumaPresident, R&D | Feb 28, 2025 | Feb 28, 2025 | A · derivative | 16,000 | $0.00 | $0 | 16,000 | No | Form 4 |
| Romano KathrynChief Accounting Officer | Feb 28, 2025 | Feb 28, 2025 | M | 5,000 | $0.00 | $0 | 17,604 | Yes | Form 4 |
| Romano KathrynChief Accounting Officer | Feb 28, 2025 | Feb 28, 2025 | F | 2,315 | $179.25 | $414,964 | 15,289 | Yes | Form 4 |
| Romano KathrynChief Accounting Officer | Feb 28, 2025 | Feb 28, 2025 | M | 7,500 | $0.00 | $0 | 22,789 | Yes | Form 4 |
| Romano KathrynChief Accounting Officer | Feb 28, 2025 | Feb 28, 2025 | F | 3,471 | $179.25 | $622,177 | 19,318 | Yes | Form 4 |
| Romano KathrynChief Accounting Officer | Feb 28, 2025 | Feb 28, 2025 | M · derivative | 5,000 | $0.00 | $0 | not reported | Yes | Form 4 |
| Romano KathrynChief Accounting Officer | Feb 28, 2025 | Feb 28, 2025 | M · derivative | 7,500 | $0.00 | $0 | 7,500 | Yes | Form 4 |
| Romano KathrynChief Accounting Officer | Feb 28, 2025 | Feb 28, 2025 | A · derivative | 10,000 | $179.25 | $1,792,500 | 10,000 | Yes | Form 4 |
| Romano KathrynChief Accounting Officer | Feb 28, 2025 | Feb 28, 2025 | A · derivative | 2,200 | $0.00 | $0 | 2,200 | Yes | Form 4 |
| Romano KathrynChief Accounting Officer | Feb 27, 2025 | Feb 28, 2025 | S | 750 | $175.22 | Sale −$131,415 | 12,604 | Yes | Form 4 |
| Krishnan Krish SPresident and CEO | Feb 26, 2025 | Feb 28, 2025 | F | 4,721 | $176.39 | $832,737 | 1,532,541 | No | Form 4 |
| Krishnan Krish SPresident and CEO | Feb 26, 2025 | Feb 28, 2025 | F | 3,286 | $176.39 | $579,618 | 1,488,711 | No | Form 4 |
| Krishnan SumaPresident, R&D | Feb 26, 2025 | Feb 28, 2025 | F | 3,286 | $176.39 | $579,618 | 1,472,596 | No | Form 4 |
| Krishnan SumaPresident, R&D | Feb 26, 2025 | Feb 28, 2025 | F | 4,721 | $176.39 | $832,737 | 1,558,056 | No | Form 4 |
| Romano KathrynChief Accounting Officer | Feb 26, 2025 | Feb 28, 2025 | F | 2,268 | $176.39 | $400,053 | 13,354 | Yes | Form 4 |
| Krishnan Krish SPresident and CEO | Dec 13, 2024 | Dec 13, 2024 | S | 6,302 | $163.07 | Sale −$1,027,667 | 1,555,960 | Yes | Form 4 |
| Krishnan Krish SPresident and CEO | Dec 13, 2024 | Dec 13, 2024 | S | 8,381 | $163.91 | Sale −$1,373,730 | 1,547,579 | Yes | Form 4 |
| Krishnan Krish SPresident and CEO | Dec 13, 2024 | Dec 13, 2024 | S | 4,909 | $164.93 | Sale −$809,641 | 1,542,670 | Yes | Form 4 |
| Krishnan Krish SPresident and CEO | Dec 13, 2024 | Dec 13, 2024 | S | 1,977 | $165.82 | Sale −$327,826 | 1,540,693 | Yes | Form 4 |
| Krishnan Krish SPresident and CEO | Dec 13, 2024 | Dec 13, 2024 | S | 923 | $166.93 | Sale −$154,076 | 1,539,770 | Yes | Form 4 |
| Krishnan Krish SPresident and CEO | Dec 13, 2024 | Dec 13, 2024 | S | 911 | $169.65 | Sale −$154,551 | 1,538,859 | Yes | Form 4 |
| Krishnan Krish SPresident and CEO | Dec 13, 2024 | Dec 13, 2024 | S | 957 | $170.47 | Sale −$163,140 | 1,537,902 | Yes | Form 4 |
| Krishnan Krish SPresident and CEO | Dec 13, 2024 | Dec 13, 2024 | S | 640 | $171.63 | Sale −$109,843 | 1,537,262 | Yes | Form 4 |
| Krishnan Krish SPresident and CEO | Dec 13, 2024 | Dec 13, 2024 | S | 5,942 | $163.04 | Sale −$968,784 | 1,494,940 | Yes | Form 4 |
| Krishnan Krish SPresident and CEO | Dec 13, 2024 | Dec 13, 2024 | S | 8,923 | $163.92 | Sale −$1,462,658 | 1,486,017 | Yes | Form 4 |
| Krishnan Krish SPresident and CEO | Dec 13, 2024 | Dec 13, 2024 | S | 4,723 | $164.92 | Sale −$778,917 | 1,481,294 | Yes | Form 4 |
| Krishnan Krish SPresident and CEO | Dec 13, 2024 | Dec 13, 2024 | S | 2,114 | $165.79 | Sale −$350,480 | 1,479,180 | Yes | Form 4 |
| Krishnan Krish SPresident and CEO | Dec 13, 2024 | Dec 13, 2024 | S | 798 | $166.96 | Sale −$133,234 | 1,478,382 | Yes | Form 4 |
| Krishnan Krish SPresident and CEO | Dec 13, 2024 | Dec 13, 2024 | S | 200 | $168.31 | Sale −$33,662 | 1,478,182 | Yes | Form 4 |
| Krishnan Krish SPresident and CEO | Dec 13, 2024 | Dec 13, 2024 | S | 953 | $169.48 | Sale −$161,514 | 1,477,229 | Yes | Form 4 |
| Krishnan Krish SPresident and CEO | Dec 13, 2024 | Dec 13, 2024 | S | 727 | $170.43 | Sale −$123,903 | 1,476,502 | Yes | Form 4 |
| Krishnan Krish SPresident and CEO | Dec 13, 2024 | Dec 13, 2024 | S | 620 | $171.62 | Sale −$106,404 | 1,475,882 | Yes | Form 4 |
| Krishnan SumaPresident, R&D | Dec 13, 2024 | Dec 13, 2024 | S | 5,942 | $163.04 | Sale −$968,784 | 1,494,940 | Yes | Form 4 |
| Krishnan SumaPresident, R&D | Dec 13, 2024 | Dec 13, 2024 | S | 8,923 | $163.92 | Sale −$1,462,658 | 1,486,017 | Yes | Form 4 |
| Krishnan SumaPresident, R&D | Dec 13, 2024 | Dec 13, 2024 | S | 4,723 | $164.92 | Sale −$778,917 | 1,481,294 | Yes | Form 4 |
| Krishnan SumaPresident, R&D | Dec 13, 2024 | Dec 13, 2024 | S | 2,114 | $165.79 | Sale −$350,480 | 1,479,180 | Yes | Form 4 |
| Krishnan SumaPresident, R&D | Dec 13, 2024 | Dec 13, 2024 | S | 798 | $166.96 | Sale −$133,234 | 1,478,382 | Yes | Form 4 |
| Krishnan SumaPresident, R&D | Dec 13, 2024 | Dec 13, 2024 | S | 200 | $168.31 | Sale −$33,662 | 1,478,182 | Yes | Form 4 |
| Krishnan SumaPresident, R&D | Dec 13, 2024 | Dec 13, 2024 | S | 953 | $169.48 | Sale −$161,514 | 1,477,229 | Yes | Form 4 |
| Krishnan SumaPresident, R&D | Dec 13, 2024 | Dec 13, 2024 | S | 727 | $170.43 | Sale −$123,903 | 1,476,502 | Yes | Form 4 |
| Krishnan SumaPresident, R&D | Dec 13, 2024 | Dec 13, 2024 | S | 620 | $171.62 | Sale −$106,404 | 1,475,882 | Yes | Form 4 |
| Krishnan SumaPresident, R&D | Dec 13, 2024 | Dec 13, 2024 | S | 6,302 | $163.07 | Sale −$1,027,667 | 1,555,960 | Yes | Form 4 |
| Krishnan SumaPresident, R&D | Dec 13, 2024 | Dec 13, 2024 | S | 8,381 | $163.91 | Sale −$1,373,730 | 1,547,579 | Yes | Form 4 |
| Krishnan SumaPresident, R&D | Dec 13, 2024 | Dec 13, 2024 | S | 4,909 | $164.93 | Sale −$809,641 | 1,542,670 | Yes | Form 4 |
| Krishnan SumaPresident, R&D | Dec 13, 2024 | Dec 13, 2024 | S | 1,977 | $165.82 | Sale −$327,826 | 1,540,693 | Yes | Form 4 |
| Krishnan SumaPresident, R&D | Dec 13, 2024 | Dec 13, 2024 | S | 923 | $166.93 | Sale −$154,076 | 1,539,770 | Yes | Form 4 |
| Krishnan SumaPresident, R&D | Dec 13, 2024 | Dec 13, 2024 | S | 911 | $169.65 | Sale −$154,551 | 1,538,859 | Yes | Form 4 |
| Krishnan SumaPresident, R&D | Dec 13, 2024 | Dec 13, 2024 | S | 957 | $170.47 | Sale −$163,140 | 1,537,902 | Yes | Form 4 |
| Krishnan SumaPresident, R&D | Dec 13, 2024 | Dec 13, 2024 | S | 640 | $171.63 | Sale −$109,843 | 1,537,262 | Yes | Form 4 |
| Rossi Dino A | Sep 13, 2024 | Sep 13, 2024 | G | 5,000 | $0.00 | $0 | 78,691 | No | Form 4 |
| Krishnan Krish SPresident and CEO | Sep 12, 2024 | Sep 13, 2024 | S | 3,957 | $195.16 | Sale −$772,248 | 1,583,305 | Yes | Form 4 |
| Krishnan Krish SPresident and CEO | Sep 12, 2024 | Sep 13, 2024 | S | 6,458 | $195.72 | Sale −$1,263,960 | 1,576,847 | Yes | Form 4 |
| Krishnan Krish SPresident and CEO | Sep 12, 2024 | Sep 13, 2024 | S | 1,696 | $197.04 | Sale −$334,180 | 1,575,151 | Yes | Form 4 |
| Krishnan Krish SPresident and CEO | Sep 12, 2024 | Sep 13, 2024 | S | 2,086 | $198.08 | Sale −$413,195 | 1,573,065 | Yes | Form 4 |
| Krishnan Krish SPresident and CEO | Sep 12, 2024 | Sep 13, 2024 | S | 4,008 | $198.93 | Sale −$797,311 | 1,569,057 | Yes | Form 4 |
| Krishnan Krish SPresident and CEO | Sep 12, 2024 | Sep 13, 2024 | S | 3,600 | $200.15 | Sale −$720,540 | 1,565,457 | Yes | Form 4 |
| Krishnan Krish SPresident and CEO | Sep 12, 2024 | Sep 13, 2024 | S | 2,395 | $200.98 | Sale −$481,347 | 1,563,062 | Yes | Form 4 |
| Krishnan Krish SPresident and CEO | Sep 12, 2024 | Sep 13, 2024 | S | 800 | $201.81 | Sale −$161,448 | 1,562,262 | Yes | Form 4 |
| Krishnan Krish SPresident and CEO | Sep 12, 2024 | Sep 13, 2024 | S | 8,497 | $195.43 | Sale −$1,660,569 | 1,517,385 | Yes | Form 4 |
| Krishnan Krish SPresident and CEO | Sep 12, 2024 | Sep 13, 2024 | S | 2,727 | $196.07 | Sale −$534,683 | 1,514,658 | Yes | Form 4 |
| Krishnan Krish SPresident and CEO | Sep 12, 2024 | Sep 13, 2024 | S | 1,385 | $197.55 | Sale −$273,607 | 1,513,273 | Yes | Form 4 |
| Krishnan Krish SPresident and CEO | Sep 12, 2024 | Sep 13, 2024 | S | 3,392 | $198.43 | Sale −$673,075 | 1,509,881 | Yes | Form 4 |
| Krishnan Krish SPresident and CEO | Sep 12, 2024 | Sep 13, 2024 | S | 2,945 | $199.22 | Sale −$586,703 | 1,506,936 | Yes | Form 4 |
| Krishnan Krish SPresident and CEO | Sep 12, 2024 | Sep 13, 2024 | S | 4,159 | $200.41 | Sale −$833,505 | 1,502,777 | Yes | Form 4 |
| Krishnan Krish SPresident and CEO | Sep 12, 2024 | Sep 13, 2024 | S | 1,895 | $201.52 | Sale −$381,880 | 1,500,882 | Yes | Form 4 |
| Krishnan SumaPresident, R&D | Sep 12, 2024 | Sep 13, 2024 | S | 8,497 | $195.43 | Sale −$1,660,569 | 1,517,385 | Yes | Form 4 |
| Krishnan SumaPresident, R&D | Sep 12, 2024 | Sep 13, 2024 | S | 2,727 | $196.07 | Sale −$534,683 | 1,514,658 | Yes | Form 4 |
| Krishnan SumaPresident, R&D | Sep 12, 2024 | Sep 13, 2024 | S | 1,385 | $197.55 | Sale −$273,607 | 1,513,273 | Yes | Form 4 |
| Krishnan SumaPresident, R&D | Sep 12, 2024 | Sep 13, 2024 | S | 3,392 | $198.43 | Sale −$673,075 | 1,509,881 | Yes | Form 4 |
| Krishnan SumaPresident, R&D | Sep 12, 2024 | Sep 13, 2024 | S | 2,945 | $199.22 | Sale −$586,703 | 1,506,936 | Yes | Form 4 |
| Krishnan SumaPresident, R&D | Sep 12, 2024 | Sep 13, 2024 | S | 4,159 | $200.41 | Sale −$833,505 | 1,502,777 | Yes | Form 4 |
| Krishnan SumaPresident, R&D | Sep 12, 2024 | Sep 13, 2024 | S | 1,895 | $201.52 | Sale −$381,880 | 1,500,882 | Yes | Form 4 |
| Krishnan SumaPresident, R&D | Sep 12, 2024 | Sep 13, 2024 | S | 3,957 | $195.16 | Sale −$772,248 | 1,583,305 | Yes | Form 4 |
| Krishnan SumaPresident, R&D | Sep 12, 2024 | Sep 13, 2024 | S | 6,458 | $195.72 | Sale −$1,263,960 | 1,576,847 | Yes | Form 4 |
| Krishnan SumaPresident, R&D | Sep 12, 2024 | Sep 13, 2024 | S | 1,696 | $197.04 | Sale −$334,180 | 1,575,151 | Yes | Form 4 |
| Krishnan SumaPresident, R&D | Sep 12, 2024 | Sep 13, 2024 | S | 2,086 | $198.08 | Sale −$413,195 | 1,573,065 | Yes | Form 4 |
| Krishnan SumaPresident, R&D | Sep 12, 2024 | Sep 13, 2024 | S | 4,008 | $198.93 | Sale −$797,311 | 1,569,057 | Yes | Form 4 |
| Krishnan SumaPresident, R&D | Sep 12, 2024 | Sep 13, 2024 | S | 3,600 | $200.15 | Sale −$720,540 | 1,565,457 | Yes | Form 4 |
| Krishnan SumaPresident, R&D | Sep 12, 2024 | Sep 13, 2024 | S | 2,395 | $200.98 | Sale −$481,347 | 1,563,062 | Yes | Form 4 |
| Krishnan SumaPresident, R&D | Sep 12, 2024 | Sep 13, 2024 | S | 800 | $201.81 | Sale −$161,448 | 1,562,262 | Yes | Form 4 |
| Rossi Dino A | Jun 30, 2024 | Jul 1, 2024 | A · derivative | 5,000 | $183.64 | $918,200 | 5,000 | No | Form 4 |
| Gangolli Julian S | Jun 30, 2024 | Jul 1, 2024 | A · derivative | 5,000 | $183.64 | $918,200 | 5,000 | No | Form 4 |
| Janney Daniel | Jun 30, 2024 | Jul 1, 2024 | A · derivative | 5,000 | $183.64 | $918,200 | 5,000 | No | Form 4 |
| Mason Christopher | Jun 30, 2024 | Jul 1, 2024 | A · derivative | 5,000 | $183.64 | $918,200 | 5,000 | No | Form 4 |
| Sutherland Everett Rand | Jun 30, 2024 | Jul 1, 2024 | A · derivative | 5,000 | $183.64 | $918,200 | 5,000 | No | Form 4 |
| Mazzacco Catherine | Jun 30, 2024 | Jul 1, 2024 | A · derivative | 5,000 | $183.64 | $918,200 | 5,000 | No | Form 4 |
| Krishnan Krish SPresident and CEO | Jun 11, 2024 | Jun 11, 2024 | S | 1,100 | $171.49 | Sale −$188,639 | 1,611,162 | Yes | Form 4 |
| Krishnan Krish SPresident and CEO | Jun 11, 2024 | Jun 11, 2024 | S | 1,882 | $172.21 | Sale −$324,099 | 1,609,280 | Yes | Form 4 |
| Krishnan Krish SPresident and CEO | Jun 11, 2024 | Jun 11, 2024 | S | 1,318 | $173.49 | Sale −$228,660 | 1,607,962 | Yes | Form 4 |
| Krishnan Krish SPresident and CEO | Jun 11, 2024 | Jun 11, 2024 | S | 4,000 | $174.83 | Sale −$699,320 | 1,603,962 | Yes | Form 4 |
| Krishnan Krish SPresident and CEO | Jun 11, 2024 | Jun 11, 2024 | S | 4,550 | $175.76 | Sale −$799,708 | 1,599,412 | Yes | Form 4 |
| Krishnan Krish SPresident and CEO | Jun 11, 2024 | Jun 11, 2024 | S | 5,705 | $176.68 | Sale −$1,007,959 | 1,593,707 | Yes | Form 4 |
| Krishnan Krish SPresident and CEO | Jun 11, 2024 | Jun 11, 2024 | S | 5,447 | $177.68 | Sale −$967,823 | 1,588,260 | Yes | Form 4 |
| Krishnan Krish SPresident and CEO | Jun 11, 2024 | Jun 11, 2024 | S | 998 | $178.36 | Sale −$178,003 | 1,587,262 | Yes | Form 4 |
| Krishnan Krish SPresident and CEO | Jun 11, 2024 | Jun 11, 2024 | S | 900 | $171.40 | Sale −$154,260 | 1,549,982 | Yes | Form 4 |
| Krishnan Krish SPresident and CEO | Jun 11, 2024 | Jun 11, 2024 | S | 2,099 | $172.24 | Sale −$361,532 | 1,547,883 | Yes | Form 4 |
| Krishnan Krish SPresident and CEO | Jun 11, 2024 | Jun 11, 2024 | S | 1,206 | $173.41 | Sale −$209,132 | 1,546,677 | Yes | Form 4 |
| Krishnan Krish SPresident and CEO | Jun 11, 2024 | Jun 11, 2024 | S | 1,724 | $174.50 | Sale −$300,838 | 1,544,953 | Yes | Form 4 |
| Krishnan Krish SPresident and CEO | Jun 11, 2024 | Jun 11, 2024 | S | 4,975 | $175.33 | Sale −$872,267 | 1,539,978 | Yes | Form 4 |
| Krishnan Krish SPresident and CEO | Jun 11, 2024 | Jun 11, 2024 | S | 5,867 | $176.38 | Sale −$1,034,821 | 1,534,111 | Yes | Form 4 |
| Krishnan Krish SPresident and CEO | Jun 11, 2024 | Jun 11, 2024 | S | 6,358 | $177.38 | Sale −$1,127,782 | 1,527,753 | Yes | Form 4 |
| Krishnan Krish SPresident and CEO | Jun 11, 2024 | Jun 11, 2024 | S | 1,871 | $178.14 | Sale −$333,300 | 1,525,882 | Yes | Form 4 |
| Krishnan SumaPresident, R&D | Jun 11, 2024 | Jun 11, 2024 | S | 900 | $171.40 | Sale −$154,260 | 1,549,982 | Yes | Form 4 |
| Krishnan SumaPresident, R&D | Jun 11, 2024 | Jun 11, 2024 | S | 2,099 | $172.24 | Sale −$361,532 | 1,547,883 | Yes | Form 4 |
| Krishnan SumaPresident, R&D | Jun 11, 2024 | Jun 11, 2024 | S | 1,206 | $173.41 | Sale −$209,132 | 1,546,677 | Yes | Form 4 |
| Krishnan SumaPresident, R&D | Jun 11, 2024 | Jun 11, 2024 | S | 1,724 | $174.50 | Sale −$300,838 | 1,544,953 | Yes | Form 4 |
| Krishnan SumaPresident, R&D | Jun 11, 2024 | Jun 11, 2024 | S | 4,975 | $175.33 | Sale −$872,267 | 1,539,978 | Yes | Form 4 |
| Krishnan SumaPresident, R&D | Jun 11, 2024 | Jun 11, 2024 | S | 5,867 | $176.38 | Sale −$1,034,821 | 1,534,111 | Yes | Form 4 |
| Krishnan SumaPresident, R&D | Jun 11, 2024 | Jun 11, 2024 | S | 6,358 | $177.38 | Sale −$1,127,782 | 1,527,753 | Yes | Form 4 |
| Krishnan SumaPresident, R&D | Jun 11, 2024 | Jun 11, 2024 | S | 1,871 | $178.14 | Sale −$333,300 | 1,525,882 | Yes | Form 4 |
| Krishnan SumaPresident, R&D | Jun 11, 2024 | Jun 11, 2024 | S | 1,100 | $171.49 | Sale −$188,639 | 1,611,162 | Yes | Form 4 |
| Krishnan SumaPresident, R&D | Jun 11, 2024 | Jun 11, 2024 | S | 1,882 | $172.21 | Sale −$324,099 | 1,609,280 | Yes | Form 4 |
| Krishnan SumaPresident, R&D | Jun 11, 2024 | Jun 11, 2024 | S | 1,318 | $173.49 | Sale −$228,660 | 1,607,962 | Yes | Form 4 |
| Krishnan SumaPresident, R&D | Jun 11, 2024 | Jun 11, 2024 | S | 4,000 | $174.83 | Sale −$699,320 | 1,603,962 | Yes | Form 4 |
| Krishnan SumaPresident, R&D | Jun 11, 2024 | Jun 11, 2024 | S | 4,550 | $175.76 | Sale −$799,708 | 1,599,412 | Yes | Form 4 |
| Krishnan SumaPresident, R&D | Jun 11, 2024 | Jun 11, 2024 | S | 5,705 | $176.68 | Sale −$1,007,959 | 1,593,707 | Yes | Form 4 |
| Krishnan SumaPresident, R&D | Jun 11, 2024 | Jun 11, 2024 | S | 5,447 | $177.68 | Sale −$967,823 | 1,588,260 | Yes | Form 4 |
| Krishnan SumaPresident, R&D | Jun 11, 2024 | Jun 11, 2024 | S | 998 | $178.36 | Sale −$178,003 | 1,587,262 | Yes | Form 4 |
| Gangolli Julian S | May 20, 2024 | May 22, 2024 | M | 20,000 | $22.75 | $455,000 | 20,000 | No | Form 4 |
| Gangolli Julian S | May 20, 2024 | May 22, 2024 | S | 10,930 | $163.71 | Sale −$1,789,350 | 9,070 | No | Form 4 |
| Gangolli Julian S | May 20, 2024 | May 22, 2024 | S | 7,090 | $164.34 | Sale −$1,165,171 | 1,980 | No | Form 4 |
| Gangolli Julian S | May 20, 2024 | May 22, 2024 | S | 1,980 | $165.76 | Sale −$328,205 | not reported | No | Form 4 |
| Gangolli Julian S | May 20, 2024 | May 22, 2024 | M · derivative | 20,000 | $22.75 | $455,000 | not reported | No | Form 4 |
| Krishnan Krish SPresident and CEO | Mar 11, 2024 | Mar 11, 2024 | S | 2,146 | $167.99 | Sale −$360,507 | 1,635,116 | Yes | Form 4 |
| Krishnan Krish SPresident and CEO | Mar 11, 2024 | Mar 11, 2024 | S | 2,254 | $168.88 | Sale −$380,656 | 1,632,862 | Yes | Form 4 |
| Krishnan Krish SPresident and CEO | Mar 11, 2024 | Mar 11, 2024 | S | 5,109 | $170.32 | Sale −$870,165 | 1,627,753 | Yes | Form 4 |
| Krishnan Krish SPresident and CEO | Mar 11, 2024 | Mar 11, 2024 | S | 8,002 | $170.93 | Sale −$1,367,782 | 1,619,751 | Yes | Form 4 |
| Krishnan Krish SPresident and CEO | Mar 11, 2024 | Mar 11, 2024 | S | 2,816 | $172.06 | Sale −$484,521 | 1,616,935 | Yes | Form 4 |
| Krishnan Krish SPresident and CEO | Mar 11, 2024 | Mar 11, 2024 | S | 3,359 | $173.09 | Sale −$581,409 | 1,613,576 | Yes | Form 4 |
| Krishnan Krish SPresident and CEO | Mar 11, 2024 | Mar 11, 2024 | S | 1,314 | $174.00 | Sale −$228,636 | 1,612,262 | Yes | Form 4 |
| Krishnan Krish SPresident and CEO | Mar 11, 2024 | Mar 11, 2024 | S | 2,658 | $168.15 | Sale −$446,943 | 1,573,224 | Yes | Form 4 |
| Krishnan Krish SPresident and CEO | Mar 11, 2024 | Mar 11, 2024 | S | 1,646 | $168.96 | Sale −$278,108 | 1,571,578 | Yes | Form 4 |
| Krishnan Krish SPresident and CEO | Mar 11, 2024 | Mar 11, 2024 | S | 8,040 | $170.42 | Sale −$1,370,177 | 1,563,538 | Yes | Form 4 |
| Krishnan Krish SPresident and CEO | Mar 11, 2024 | Mar 11, 2024 | S | 5,469 | $171.09 | Sale −$935,691 | 1,558,069 | Yes | Form 4 |
| Krishnan Krish SPresident and CEO | Mar 11, 2024 | Mar 11, 2024 | S | 2,800 | $172.21 | Sale −$482,188 | 1,555,269 | Yes | Form 4 |
| Krishnan Krish SPresident and CEO | Mar 11, 2024 | Mar 11, 2024 | S | 3,587 | $173.30 | Sale −$621,627 | 1,551,682 | Yes | Form 4 |
| Krishnan Krish SPresident and CEO | Mar 11, 2024 | Mar 11, 2024 | S | 800 | $174.13 | Sale −$139,304 | 1,550,882 | Yes | Form 4 |
| Krishnan SumaPresident, R&D | Mar 11, 2024 | Mar 11, 2024 | S | 2,658 | $168.15 | Sale −$446,943 | 1,573,224 | Yes | Form 4 |
| Krishnan SumaPresident, R&D | Mar 11, 2024 | Mar 11, 2024 | S | 1,646 | $168.96 | Sale −$278,108 | 1,571,578 | Yes | Form 4 |
| Krishnan SumaPresident, R&D | Mar 11, 2024 | Mar 11, 2024 | S | 8,040 | $170.42 | Sale −$1,370,177 | 1,563,538 | Yes | Form 4 |
| Krishnan SumaPresident, R&D | Mar 11, 2024 | Mar 11, 2024 | S | 5,469 | $171.09 | Sale −$935,691 | 1,558,069 | Yes | Form 4 |
| Krishnan SumaPresident, R&D | Mar 11, 2024 | Mar 11, 2024 | S | 2,800 | $172.21 | Sale −$482,188 | 1,555,269 | Yes | Form 4 |
| Krishnan SumaPresident, R&D | Mar 11, 2024 | Mar 11, 2024 | S | 3,587 | $173.30 | Sale −$621,627 | 1,551,682 | Yes | Form 4 |
| Krishnan SumaPresident, R&D | Mar 11, 2024 | Mar 11, 2024 | S | 800 | $174.13 | Sale −$139,304 | 1,550,882 | Yes | Form 4 |
| Krishnan SumaPresident, R&D | Mar 11, 2024 | Mar 11, 2024 | S | 2,146 | $167.99 | Sale −$360,507 | 1,635,116 | Yes | Form 4 |
| Krishnan SumaPresident, R&D | Mar 11, 2024 | Mar 11, 2024 | S | 2,254 | $168.88 | Sale −$380,656 | 1,632,862 | Yes | Form 4 |
| Krishnan SumaPresident, R&D | Mar 11, 2024 | Mar 11, 2024 | S | 5,109 | $170.32 | Sale −$870,165 | 1,627,753 | Yes | Form 4 |
| Krishnan SumaPresident, R&D | Mar 11, 2024 | Mar 11, 2024 | S | 8,002 | $170.93 | Sale −$1,367,782 | 1,619,751 | Yes | Form 4 |
| Krishnan SumaPresident, R&D | Mar 11, 2024 | Mar 11, 2024 | S | 2,816 | $172.06 | Sale −$484,521 | 1,616,935 | Yes | Form 4 |
| Krishnan SumaPresident, R&D | Mar 11, 2024 | Mar 11, 2024 | S | 3,359 | $173.09 | Sale −$581,409 | 1,613,576 | Yes | Form 4 |
| Krishnan SumaPresident, R&D | Mar 11, 2024 | Mar 11, 2024 | S | 1,314 | $174.00 | Sale −$228,636 | 1,612,262 | Yes | Form 4 |
| Krishnan Krish SPresident and CEO | Feb 29, 2024 | Mar 1, 2024 | A · derivative | 35,000 | $0.00 | $0 | 35,000 | No | Form 4 |
| Krishnan Krish SPresident and CEO | Feb 29, 2024 | Mar 1, 2024 | A · derivative | 52,500 | $0.00 | $0 | 52,500 | No | Form 4 |
| Krishnan SumaPresident, R&D | Feb 29, 2024 | Mar 1, 2024 | A · derivative | 45,000 | $0.00 | $0 | 45,000 | No | Form 4 |
| Romano KathrynChief Accounting Officer | Feb 29, 2024 | Mar 1, 2024 | A · derivative | 15,000 | $0.00 | $0 | 15,000 | Yes | Form 4 |
| Krishnan Krish SPresident and CEO | Feb 28, 2024 | Mar 1, 2024 | M | 12,500 | $0.00 | $0 | 1,643,047 | No | Form 4 |
| Krishnan Krish SPresident and CEO | Feb 28, 2024 | Mar 1, 2024 | F | 5,785 | $163.08 | $943,418 | 1,637,262 | No | Form 4 |
| Krishnan Krish SPresident and CEO | Feb 28, 2024 | Mar 1, 2024 | M | 7,500 | $0.00 | $0 | 1,579,353 | No | Form 4 |
| Krishnan Krish SPresident and CEO | Feb 28, 2024 | Mar 1, 2024 | F | 3,471 | $163.08 | $566,051 | 1,575,882 | No | Form 4 |
| Krishnan Krish SPresident and CEO | Feb 28, 2024 | Mar 1, 2024 | M · derivative | 12,500 | $0.00 | $0 | 12,500 | No | Form 4 |
| Krishnan SumaPresident, R&D | Feb 28, 2024 | Mar 1, 2024 | M | 7,500 | $0.00 | $0 | 1,579,353 | No | Form 4 |
| Krishnan SumaPresident, R&D | Feb 28, 2024 | Mar 1, 2024 | F | 3,471 | $163.08 | $566,051 | 1,575,882 | No | Form 4 |
| Krishnan SumaPresident, R&D | Feb 28, 2024 | Mar 1, 2024 | M | 12,500 | $0.00 | $0 | 1,643,047 | No | Form 4 |
| Krishnan SumaPresident, R&D | Feb 28, 2024 | Mar 1, 2024 | F | 5,785 | $163.08 | $943,418 | 1,637,262 | No | Form 4 |
| Krishnan SumaPresident, R&D | Feb 28, 2024 | Mar 1, 2024 | M · derivative | 7,500 | $0.00 | $0 | 7,500 | No | Form 4 |
| Romano KathrynChief Accounting Officer | Feb 28, 2024 | Mar 1, 2024 | M | 523 | $63.55 | $33,237 | 13,459 | Yes | Form 4 |
| Romano KathrynChief Accounting Officer | Feb 28, 2024 | Mar 1, 2024 | S | 523 | $163.13 | Sale −$85,317 | 12,936 | Yes | Form 4 |
| Romano KathrynChief Accounting Officer | Feb 28, 2024 | Mar 1, 2024 | M | 744 | $63.55 | $47,281 | 13,680 | Yes | Form 4 |
| Romano KathrynChief Accounting Officer | Feb 28, 2024 | Mar 1, 2024 | S | 744 | $164.60 | Sale −$122,462 | 12,936 | Yes | Form 4 |
| Romano KathrynChief Accounting Officer | Feb 28, 2024 | Mar 1, 2024 | M | 130 | $63.55 | $8,262 | 13,066 | Yes | Form 4 |
| Romano KathrynChief Accounting Officer | Feb 28, 2024 | Mar 1, 2024 | S | 130 | $165.22 | Sale −$21,479 | 12,936 | Yes | Form 4 |
| Romano KathrynChief Accounting Officer | Feb 28, 2024 | Mar 1, 2024 | M | 100 | $63.55 | $6,355 | 13,036 | Yes | Form 4 |
| Romano KathrynChief Accounting Officer | Feb 28, 2024 | Mar 1, 2024 | S | 100 | $166.22 | Sale −$16,622 | 12,936 | Yes | Form 4 |
| Romano KathrynChief Accounting Officer | Feb 28, 2024 | Mar 1, 2024 | M | 700 | $63.55 | $44,485 | 13,636 | Yes | Form 4 |
| Romano KathrynChief Accounting Officer | Feb 28, 2024 | Mar 1, 2024 | S | 700 | $168.91 | Sale −$118,237 | 12,936 | Yes | Form 4 |
| Romano KathrynChief Accounting Officer | Feb 28, 2024 | Mar 1, 2024 | M | 203 | $63.55 | $12,901 | 13,139 | Yes | Form 4 |
| Romano KathrynChief Accounting Officer | Feb 28, 2024 | Mar 1, 2024 | S | 203 | $169.47 | Sale −$34,402 | 12,936 | Yes | Form 4 |
| Romano KathrynChief Accounting Officer | Feb 28, 2024 | Mar 1, 2024 | M | 100 | $63.55 | $6,355 | 13,036 | Yes | Form 4 |
| Romano KathrynChief Accounting Officer | Feb 28, 2024 | Mar 1, 2024 | S | 100 | $171.45 | Sale −$17,145 | 12,936 | Yes | Form 4 |
| Romano KathrynChief Accounting Officer | Feb 28, 2024 | Mar 1, 2024 | M | 637 | $63.55 | $40,481 | 13,573 | Yes | Form 4 |
| Romano KathrynChief Accounting Officer | Feb 28, 2024 | Mar 1, 2024 | S | 637 | $162.73 | Sale −$103,659 | 12,936 | Yes | Form 4 |
| Romano KathrynChief Accounting Officer | Feb 28, 2024 | Mar 1, 2024 | M | 786 | $63.55 | $49,950 | 13,722 | Yes | Form 4 |
| Romano KathrynChief Accounting Officer | Feb 28, 2024 | Mar 1, 2024 | S | 786 | $163.49 | Sale −$128,503 | 12,936 | Yes | Form 4 |
| Romano KathrynChief Accounting Officer | Feb 28, 2024 | Mar 1, 2024 | M | 1,600 | $63.55 | $101,680 | 14,536 | Yes | Form 4 |
| Romano KathrynChief Accounting Officer | Feb 28, 2024 | Mar 1, 2024 | S | 1,600 | $164.84 | Sale −$263,744 | 12,936 | Yes | Form 4 |
| Romano KathrynChief Accounting Officer | Feb 28, 2024 | Mar 1, 2024 | M | 200 | $63.55 | $12,710 | 13,136 | Yes | Form 4 |
| Romano KathrynChief Accounting Officer | Feb 28, 2024 | Mar 1, 2024 | S | 200 | $166.04 | Sale −$33,208 | 12,936 | Yes | Form 4 |
| Romano KathrynChief Accounting Officer | Feb 28, 2024 | Mar 1, 2024 | M | 300 | $63.55 | $19,065 | 13,236 | Yes | Form 4 |
| Romano KathrynChief Accounting Officer | Feb 28, 2024 | Mar 1, 2024 | S | 300 | $167.85 | Sale −$50,355 | 12,936 | Yes | Form 4 |
| Romano KathrynChief Accounting Officer | Feb 28, 2024 | Mar 1, 2024 | M | 1,133 | $63.55 | $72,002 | 14,069 | Yes | Form 4 |
| Romano KathrynChief Accounting Officer | Feb 28, 2024 | Mar 1, 2024 | S | 1,133 | $169.10 | Sale −$191,590 | 12,936 | Yes | Form 4 |
| Romano KathrynChief Accounting Officer | Feb 28, 2024 | Mar 1, 2024 | M | 210 | $63.55 | $13,346 | 13,146 | Yes | Form 4 |
| Romano KathrynChief Accounting Officer | Feb 28, 2024 | Mar 1, 2024 | S | 210 | $169.75 | Sale −$35,648 | 12,936 | Yes | Form 4 |
| Romano KathrynChief Accounting Officer | Feb 28, 2024 | Mar 1, 2024 | M | 134 | $63.55 | $8,516 | 13,070 | Yes | Form 4 |
| Romano KathrynChief Accounting Officer | Feb 28, 2024 | Mar 1, 2024 | S | 134 | $171.66 | Sale −$23,002 | 12,936 | Yes | Form 4 |
| Romano KathrynChief Accounting Officer | Feb 28, 2024 | Mar 1, 2024 | M · derivative | 2,500 | $63.55 | $158,875 | 35,000 | Yes | Form 4 |
| Romano KathrynChief Accounting Officer | Feb 28, 2024 | Mar 1, 2024 | M · derivative | 5,000 | $63.55 | $317,750 | 30,000 | Yes | Form 4 |
| Romano KathrynChief Accounting Officer | Feb 28, 2024 | Mar 1, 2024 | M | 648 | $63.55 | $41,180 | 13,584 | Yes | Form 4 |
| Romano KathrynChief Accounting Officer | Feb 28, 2024 | Mar 1, 2024 | S | 648 | $162.71 | Sale −$105,436 | 12,936 | Yes | Form 4 |
| Romano KathrynChief Accounting Officer | Feb 28, 2024 | Mar 1, 2024 | M | 900 | $63.55 | $57,195 | 13,836 | Yes | Form 4 |
| Romano KathrynChief Accounting Officer | Feb 28, 2024 | Mar 1, 2024 | S | 900 | $163.68 | Sale −$147,312 | 12,936 | Yes | Form 4 |
| Romano KathrynChief Accounting Officer | Feb 28, 2024 | Mar 1, 2024 | M | 1,429 | $63.55 | $90,813 | 14,365 | Yes | Form 4 |
| Romano KathrynChief Accounting Officer | Feb 28, 2024 | Mar 1, 2024 | S | 1,429 | $164.81 | Sale −$235,513 | 12,936 | Yes | Form 4 |
| Romano KathrynChief Accounting Officer | Feb 28, 2024 | Mar 1, 2024 | M | 300 | $63.55 | $19,065 | 13,236 | Yes | Form 4 |
| Romano KathrynChief Accounting Officer | Feb 28, 2024 | Mar 1, 2024 | S | 300 | $166.06 | Sale −$49,818 | 12,936 | Yes | Form 4 |
| Romano KathrynChief Accounting Officer | Feb 28, 2024 | Mar 1, 2024 | M | 300 | $63.55 | $19,065 | 13,236 | Yes | Form 4 |
| Romano KathrynChief Accounting Officer | Feb 28, 2024 | Mar 1, 2024 | S | 300 | $167.85 | Sale −$50,355 | 12,936 | Yes | Form 4 |
| Romano KathrynChief Accounting Officer | Feb 28, 2024 | Mar 1, 2024 | M | 1,216 | $63.55 | $77,277 | 14,152 | Yes | Form 4 |
| Romano KathrynChief Accounting Officer | Feb 28, 2024 | Mar 1, 2024 | S | 1,216 | $169.09 | Sale −$205,613 | 12,936 | Yes | Form 4 |
| Romano KathrynChief Accounting Officer | Feb 28, 2024 | Mar 1, 2024 | M | 117 | $63.55 | $7,435 | 13,053 | Yes | Form 4 |
| Romano KathrynChief Accounting Officer | Feb 28, 2024 | Mar 1, 2024 | S | 117 | $169.82 | Sale −$19,869 | 12,936 | Yes | Form 4 |
| Romano KathrynChief Accounting Officer | Feb 28, 2024 | Mar 1, 2024 | M | 90 | $63.55 | $5,720 | 13,026 | Yes | Form 4 |