KYMRKymera Therapeutics, Inc.
- Market cap
- $9.21B
- as of 2026-10-23
- Latest close
- $110.76
- as of 2026-10-23
- Sector
- Healthcare
- as of 2026-10-24
- Industry
- Biotechnology
- as of 2026-10-24
Cluster
No cluster in the last 90 days under the default rule (14d · ≥2 insiders · all roles).
Form 4 historysince 2023-11-06
Dashed line = amended filing (Form 4/A)
Showing the latest 500 of 613 transactions.
| Insider | Traded | Filed | Type | Shares | Price | Value | Owned after | 10b5-1 plan | Filing |
|---|---|---|---|---|---|---|---|---|---|
| Mainolfi NelloChief Executive Officer | Oct 1 | Oct 1 | M | 30,000 | $2.08 | $62,400 | 696,568 | Yes | Form 4 |
| Mainolfi NelloChief Executive Officer | Oct 1 | Oct 1 | S | 3,525 | $111.44 | Sale −$392,826 | 693,043 | Yes | Form 4 |
| Mainolfi NelloChief Executive Officer | Oct 1 | Oct 1 | S | 5,506 | $112.42 | Sale −$618,985 | 687,537 | Yes | Form 4 |
| Mainolfi NelloChief Executive Officer | Oct 1 | Oct 1 | S | 4,876 | $113.24 | Sale −$552,158 | 682,661 | Yes | Form 4 |
| Mainolfi NelloChief Executive Officer | Oct 1 | Oct 1 | S | 7,601 | $114.43 | Sale −$869,782 | 675,060 | Yes | Form 4 |
| Mainolfi NelloChief Executive Officer | Oct 1 | Oct 1 | S | 8,230 | $115.40 | Sale −$949,742 | 666,830 | Yes | Form 4 |
| Mainolfi NelloChief Executive Officer | Oct 1 | Oct 1 | S | 262 | $116.12 | Sale −$30,423 | 666,568 | Yes | Form 4 |
| Mainolfi NelloChief Executive Officer | Oct 1 | Oct 1 | M · derivative | 30,000 | $2.08 | $62,400 | 60,000 | Yes | Form 4 |
| Adams BrianChief Legal Officer | Sep 4 | Sep 4 | S | 1,209 | $115.55 | Sale −$139,700 | 55,416 | No | Form 4 |
| Adams BrianChief Legal Officer | Sep 4 | Sep 4 | S | 3,025 | $116.81 | Sale −$353,350 | 52,391 | No | Form 4 |
| Adams BrianChief Legal Officer | Sep 4 | Sep 4 | S | 2,137 | $117.57 | Sale −$251,247 | 50,254 | No | Form 4 |
| Rooney TerenceChief Medical Officer | Jul 27 | Jul 27 | A | 38,000 | $0.00 | $0 | 38,000 | No | Form 4 |
| Rooney TerenceChief Medical Officer | Jul 27 | Jul 27 | A · derivative | 76,000 | $110.05 | $8,363,800 | 76,000 | No | Form 4 |
| Mainolfi NelloChief Executive Officer | Jul 7 | Jul 7 | M | 50,000 | $2.08 | $104,000 | 716,568 | Yes | Form 4 |
| Mainolfi NelloChief Executive Officer | Jul 7 | Jul 7 | S | 50,000 | $119.00 | Sale −$5,950,000 | 666,568 | Yes | Form 4 |
| Mainolfi NelloChief Executive Officer | Jul 7 | Jul 7 | M · derivative | 45,559 | $2.08 | $94,763 | 90,000 | Yes | Form 4 |
| Mainolfi NelloChief Executive Officer | Jul 7 | Jul 7 | M · derivative | 4,441 | $2.08 | $9,237 | 14,284 | Yes | Form 4 |
| Mainolfi NelloChief Executive Officer | Jul 1 | Jul 2 | M | 80,000 | $2.08 | $166,400 | 746,568 | Yes | Form 4 |
| Mainolfi NelloChief Executive Officer | Jul 1 | Jul 2 | S | 1,883 | $112.80 | Sale −$212,402 | 744,685 | Yes | Form 4 |
| Mainolfi NelloChief Executive Officer | Jul 1 | Jul 2 | S | 6,626 | $113.98 | Sale −$755,231 | 738,059 | Yes | Form 4 |
| Mainolfi NelloChief Executive Officer | Jul 1 | Jul 2 | S | 24,105 | $114.96 | Sale −$2,771,111 | 713,954 | Yes | Form 4 |
| Mainolfi NelloChief Executive Officer | Jul 1 | Jul 2 | S | 44,050 | $115.69 | Sale −$5,096,145 | 669,904 | Yes | Form 4 |
| Mainolfi NelloChief Executive Officer | Jul 1 | Jul 2 | S | 3,336 | $116.56 | Sale −$388,844 | 666,568 | Yes | Form 4 |
| Mainolfi NelloChief Executive Officer | Jul 1 | Jul 2 | M · derivative | 80,000 | $2.08 | $166,400 | 135,559 | Yes | Form 4 |
| Goodman NoahChief Business Officer | Jul 1 | Jul 2 | S | 3,389 | $114.29 | Sale −$387,329 | 47,179.44 | Yes | Form 4 |
| Jacobs Bruce N.Chief Financial Officer | Jun 30 | Jul 2 | M | 61,378 | $5.33 | $327,145 | 321,992 | Yes | Form 4 |
| Jacobs Bruce N.Chief Financial Officer | Jun 30 | Jul 2 | S | 1,500 | $110.54 | Sale −$165,810 | 320,492 | Yes | Form 4 |
| Jacobs Bruce N.Chief Financial Officer | Jun 30 | Jul 2 | S | 1,700 | $111.57 | Sale −$189,669 | 318,792 | Yes | Form 4 |
| Jacobs Bruce N.Chief Financial Officer | Jun 30 | Jul 2 | S | 1,100 | $112.79 | Sale −$124,069 | 317,692 | Yes | Form 4 |
| Jacobs Bruce N.Chief Financial Officer | Jun 30 | Jul 2 | S | 4,110 | $114.19 | Sale −$469,321 | 313,582 | Yes | Form 4 |
| Jacobs Bruce N.Chief Financial Officer | Jun 30 | Jul 2 | S | 51,375 | $114.77 | Sale −$5,896,309 | 262,207 | Yes | Form 4 |
| Jacobs Bruce N.Chief Financial Officer | Jun 30 | Jul 2 | S | 7,971 | $115.82 | Sale −$923,201 | 254,236 | Yes | Form 4 |
| Jacobs Bruce N.Chief Financial Officer | Jun 30 | Jul 2 | S | 6,153 | $116.99 | Sale −$719,839 | 248,083 | Yes | Form 4 |
| Jacobs Bruce N.Chief Financial Officer | Jun 30 | Jul 2 | S | 3,200 | $117.70 | Sale −$376,640 | 244,883 | Yes | Form 4 |
| Jacobs Bruce N.Chief Financial Officer | Jun 30 | Jul 2 | M · derivative | 61,378 | $5.33 | $327,145 | not reported | Yes | Form 4 |
| Booth Bruce | Jun 29 | Jul 24/A | S | 5,549 | $105.78 | Sale −$586,973 | 2,446,375 | Yes | Form 4/A |
| Booth Bruce | Jun 29 | Jul 24/A | S | 14,798 | $106.63 | Sale −$1,577,911 | 2,431,577 | Yes | Form 4/A |
| Booth Bruce | Jun 29 | Jul 24/A | S | 19,419 | $107.76 | Sale −$2,092,591 | 2,412,158 | Yes | Form 4/A |
| Booth Bruce | Jun 29 | Jul 24/A | S | 10,848 | $108.28 | Sale −$1,174,621 | 2,401,310 | Yes | Form 4/A |
| Booth Bruce | Jun 29 | Jul 24/A | S | 7,968 | $109.75 | Sale −$874,488 | 2,393,342 | Yes | Form 4/A |
| Booth Bruce | Jun 29 | Jul 24/A | S | 7,723 | $110.67 | Sale −$854,704 | 2,385,619 | Yes | Form 4/A |
| Booth Bruce | Jun 29 | Jul 24/A | S | 934 | $111.20 | Sale −$103,861 | 2,384,685 | Yes | Form 4/A |
| Booth Bruce | Jun 29 | Jul 24/A | S | 770 | $105.78 | Sale −$81,451 | 471,497 | Yes | Form 4/A |
| Booth Bruce | Jun 29 | Jul 24/A | S | 2,133 | $106.63 | Sale −$227,442 | 469,364 | Yes | Form 4/A |
| Booth Bruce | Jun 29 | Jul 24/A | S | 2,698 | $107.76 | Sale −$290,736 | 466,666 | Yes | Form 4/A |
| Booth Bruce | Jun 29 | Jul 24/A | S | 1,498 | $108.28 | Sale −$162,203 | 465,168 | Yes | Form 4/A |
| Booth Bruce | Jun 29 | Jul 24/A | S | 1,104 | $109.75 | Sale −$121,164 | 464,064 | Yes | Form 4/A |
| Booth Bruce | Jun 29 | Jul 24/A | S | 1,078 | $110.67 | Sale −$119,302 | 462,986 | Yes | Form 4/A |
| Booth Bruce | Jun 29 | Jul 24/A | S | 130 | $111.20 | Sale −$14,456 | 462,856 | Yes | Form 4/A |
| Booth Bruce | Jun 29 | Jun 30 | S | 5,471 | $105.78 | Sale −$578,722 | 2,446,453 | Yes | Form 4 |
| Booth Bruce | Jun 29 | Jun 30 | S | 14,613 | $106.63 | Sale −$1,558,184 | 2,431,840 | Yes | Form 4 |
| Booth Bruce | Jun 29 | Jun 30 | S | 19,093 | $107.76 | Sale −$2,057,462 | 2,412,747 | Yes | Form 4 |
| Booth Bruce | Jun 29 | Jun 30 | S | 848 | $105.78 | Sale −$89,701 | 471,419 | Yes | Form 4 |
| Booth Bruce | Jun 29 | Jun 30 | S | 2,318 | $106.63 | Sale −$247,168 | 469,101 | Yes | Form 4 |
| Booth Bruce | Jun 29 | Jun 30 | S | 3,024 | $107.76 | Sale −$325,866 | 466,077 | Yes | Form 4 |
| Booth Bruce | Jun 26 | Jun 30 | S | 28,296 | $107.57 | Sale −$3,043,801 | 2,834,055 | Yes | Form 4 |
| Booth Bruce | Jun 26 | Jun 30 | S | 231,007 | $108.14 | Sale −$24,981,097 | 2,603,048 | Yes | Form 4 |
| Booth Bruce | Jun 26 | Jun 30 | S | 32,624 | $109.79 | Sale −$3,581,789 | 2,570,424 | Yes | Form 4 |
| Booth Bruce | Jun 26 | Jun 30 | S | 11,277 | $110.49 | Sale −$1,245,996 | 2,559,147 | Yes | Form 4 |
| Booth Bruce | Jun 26 | Jun 30 | S | 10,366 | $111.51 | Sale −$1,155,913 | 2,548,781 | Yes | Form 4 |
| Booth Bruce | Jun 26 | Jun 30 | S | 555 | $112.49 | Sale −$62,432 | 2,548,226 | Yes | Form 4 |
| Booth Bruce | Jun 26 | Jun 30 | S | 14,913 | $113.97 | Sale −$1,699,635 | 2,533,313 | Yes | Form 4 |
| Booth Bruce | Jun 26 | Jun 30 | S | 27,951 | $114.94 | Sale −$3,212,688 | 2,505,362 | Yes | Form 4 |
| Booth Bruce | Jun 26 | Jun 30 | S | 6,821 | $115.69 | Sale −$789,121 | 2,498,541 | Yes | Form 4 |
| Booth Bruce | Jun 26 | Jun 30 | S | 12,181 | $117.09 | Sale −$1,426,273 | 2,486,360 | Yes | Form 4 |
| Booth Bruce | Jun 26 | Jun 30 | S | 22,046 | $117.85 | Sale −$2,598,121 | 2,464,314 | Yes | Form 4 |
| Booth Bruce | Jun 26 | Jun 30 | S | 12,390 | $118.66 | Sale −$1,470,197 | 2,451,924 | Yes | Form 4 |
| Booth Bruce | Jun 26 | Jun 30 | S | 3,958 | $107.57 | Sale −$425,762 | 525,760 | Yes | Form 4 |
| Booth Bruce | Jun 26 | Jun 30 | S | 32,402 | $108.14 | Sale −$3,503,952 | 493,358 | Yes | Form 4 |
| Booth Bruce | Jun 26 | Jun 30 | S | 4,562 | $109.79 | Sale −$500,862 | 488,796 | Yes | Form 4 |
| Booth Bruce | Jun 26 | Jun 30 | S | 1,579 | $110.49 | Sale −$174,464 | 487,217 | Yes | Form 4 |
| Booth Bruce | Jun 26 | Jun 30 | S | 1,442 | $111.51 | Sale −$160,797 | 485,775 | Yes | Form 4 |
| Booth Bruce | Jun 26 | Jun 30 | S | 78 | $112.49 | Sale −$8,774 | 485,697 | Yes | Form 4 |
| Booth Bruce | Jun 26 | Jun 30 | S | 2,083 | $113.97 | Sale −$237,400 | 483,614 | Yes | Form 4 |
| Booth Bruce | Jun 26 | Jun 30 | S | 3,896 | $114.94 | Sale −$447,806 | 479,718 | Yes | Form 4 |
| Booth Bruce | Jun 26 | Jun 30 | S | 952 | $115.69 | Sale −$110,137 | 478,766 | Yes | Form 4 |
| Booth Bruce | Jun 26 | Jun 30 | S | 1,701 | $117.09 | Sale −$199,170 | 477,065 | Yes | Form 4 |
| Booth Bruce | Jun 26 | Jun 30 | S | 3,069 | $117.85 | Sale −$361,682 | 473,996 | Yes | Form 4 |
| Booth Bruce | Jun 26 | Jun 30 | S | 1,729 | $118.66 | Sale −$205,163 | 472,267 | Yes | Form 4 |
| Biotechnology Value Fund II LP | Jun 26 | Jun 26 | S | 837,914 | $106.50 | Sale −$89,237,841 | 1,960,881 | No | Form 4 |
| Biotechnology Value Fund II LP | Jun 26 | Jun 26 | S | 627,597 | $106.50 | Sale −$66,839,081 | 1,592,261 | No | Form 4 |
| Biotechnology Value Fund II LP | Jun 26 | Jun 26 | S | 113,289 | $106.50 | Sale −$12,065,279 | 240,123 | No | Form 4 |
| Biotechnology Value Fund II LP | Jun 26 | Jun 26 | S | 51,858 | $106.50 | Sale −$5,522,877 | 78,787 | No | Form 4 |
| Goodman NoahChief Business Officer | Jun 25 | Jun 25 | M | 5,000 | $21.05 | $105,250 | 55,195.44 | Yes | Form 4 |
| Goodman NoahChief Business Officer | Jun 25 | Jun 25 | S | 2,500 | $109.00 | Sale −$272,500 | 52,695.44 | Yes | Form 4 |
| Goodman NoahChief Business Officer | Jun 25 | Jun 25 | S | 2,500 | $119.00 | Sale −$297,500 | 50,195.44 | Yes | Form 4 |
| Goodman NoahChief Business Officer | Jun 25 | Jun 25 | M · derivative | 5,000 | $21.05 | $105,250 | 90,000 | Yes | Form 4 |
| Booth Bruce | Jun 25 | Jun 25 | S | 9,994 | $107.30 | Sale −$1,072,356 | 3,333,349 | Yes | Form 4 |
| Booth Bruce | Jun 25 | Jun 25 | S | 159 | $108.02 | Sale −$17,175 | 3,333,190 | Yes | Form 4 |
| Booth Bruce | Jun 25 | Jun 25 | S | 14,351 | $108.83 | Sale −$1,561,819 | 3,318,839 | Yes | Form 4 |
| Booth Bruce | Jun 25 | Jun 25 | S | 1,915 | $110.30 | Sale −$211,225 | 3,316,924 | Yes | Form 4 |
| Booth Bruce | Jun 25 | Jun 25 | S | 614 | $110.79 | Sale −$68,025 | 3,316,310 | Yes | Form 4 |
| Booth Bruce | Jun 25 | Jun 25 | S | 719 | $111.89 | Sale −$80,449 | 3,315,591 | Yes | Form 4 |
| Booth Bruce | Jun 25 | Jun 25 | S | 10,215 | $113.70 | Sale −$1,161,446 | 3,305,376 | Yes | Form 4 |
| Booth Bruce | Jun 25 | Jun 25 | S | 9,229 | $114.65 | Sale −$1,058,105 | 3,296,147 | Yes | Form 4 |
| Booth Bruce | Jun 25 | Jun 25 | S | 58,205 | $115.57 | Sale −$6,726,752 | 3,237,942 | Yes | Form 4 |
| Booth Bruce | Jun 25 | Jun 25 | S | 81,500 | $116.53 | Sale −$9,497,195 | 3,156,442 | Yes | Form 4 |
| Booth Bruce | Jun 25 | Jun 25 | S | 24,268 | $117.50 | Sale −$2,851,490 | 3,132,174 | Yes | Form 4 |
| Booth Bruce | Jun 25 | Jun 25 | S | 19,089 | $118.60 | Sale −$2,263,955 | 3,113,085 | Yes | Form 4 |
| Booth Bruce | Jun 25 | Jun 25 | S | 1,399 | $107.30 | Sale −$150,113 | 595,648 | Yes | Form 4 |
| Booth Bruce | Jun 25 | Jun 25 | S | 23 | $108.02 | Sale −$2,484 | 595,625 | Yes | Form 4 |
| Booth Bruce | Jun 25 | Jun 25 | S | 2,011 | $108.83 | Sale −$218,857 | 593,614 | Yes | Form 4 |
| Booth Bruce | Jun 25 | Jun 25 | S | 265 | $110.30 | Sale −$29,230 | 593,349 | Yes | Form 4 |
| Booth Bruce | Jun 25 | Jun 25 | S | 86 | $110.79 | Sale −$9,528 | 593,263 | Yes | Form 4 |
| Booth Bruce | Jun 25 | Jun 25 | S | 100 | $111.89 | Sale −$11,189 | 593,163 | Yes | Form 4 |
| Booth Bruce | Jun 25 | Jun 25 | S | 1,437 | $113.70 | Sale −$163,387 | 591,726 | Yes | Form 4 |
| Booth Bruce | Jun 25 | Jun 25 | S | 1,289 | $114.65 | Sale −$147,784 | 590,437 | Yes | Form 4 |
| Booth Bruce | Jun 25 | Jun 25 | S | 8,389 | $115.57 | Sale −$969,517 | 582,048 | Yes | Form 4 |
| Booth Bruce | Jun 25 | Jun 25 | S | 11,375 | $116.53 | Sale −$1,325,529 | 570,673 | Yes | Form 4 |
| Booth Bruce | Jun 25 | Jun 25 | S | 3,359 | $117.50 | Sale −$394,683 | 567,314 | Yes | Form 4 |
| Booth Bruce | Jun 25 | Jun 25 | S | 2,646 | $118.60 | Sale −$313,816 | 564,668 | Yes | Form 4 |
| Booth Bruce | Jun 25 | Jun 25 | S | 37,179 | $119.71 | Sale −$4,450,698 | 3,075,906 | Yes | Form 4 |
| Booth Bruce | Jun 25 | Jun 25 | S | 112,299 | $120.66 | Sale −$13,549,997 | 2,963,607 | Yes | Form 4 |
| Booth Bruce | Jun 25 | Jun 25 | S | 40,774 | $121.38 | Sale −$4,949,148 | 2,922,833 | Yes | Form 4 |
| Booth Bruce | Jun 25 | Jun 25 | S | 4,977 | $122.67 | Sale −$610,529 | 2,917,856 | Yes | Form 4 |
| Booth Bruce | Jun 25 | Jun 25 | S | 10,860 | $123.62 | Sale −$1,342,513 | 2,906,996 | Yes | Form 4 |
| Booth Bruce | Jun 25 | Jun 25 | S | 11,711 | $124.61 | Sale −$1,459,308 | 2,895,285 | Yes | Form 4 |
| Booth Bruce | Jun 25 | Jun 25 | S | 3,716 | $125.82 | Sale −$467,547 | 2,891,569 | Yes | Form 4 |
| Booth Bruce | Jun 25 | Jun 25 | S | 1,609 | $126.71 | Sale −$203,876 | 2,889,960 | Yes | Form 4 |
| Booth Bruce | Jun 25 | Jun 25 | S | 25,075 | $127.37 | Sale −$3,193,803 | 2,864,885 | Yes | Form 4 |
| Booth Bruce | Jun 25 | Jun 25 | S | 2,197 | $128.69 | Sale −$282,732 | 2,862,688 | Yes | Form 4 |
| Booth Bruce | Jun 25 | Jun 25 | S | 337 | $129.61 | Sale −$43,679 | 2,862,351 | Yes | Form 4 |
| Booth Bruce | Jun 25 | Jun 25 | S | 5,144 | $119.71 | Sale −$615,788 | 559,524 | Yes | Form 4 |
| Booth Bruce | Jun 25 | Jun 25 | S | 15,660 | $120.66 | Sale −$1,889,536 | 543,864 | Yes | Form 4 |
| Booth Bruce | Jun 25 | Jun 25 | S | 5,689 | $121.38 | Sale −$690,531 | 538,175 | Yes | Form 4 |
| Booth Bruce | Jun 25 | Jun 25 | S | 698 | $122.67 | Sale −$85,624 | 537,477 | Yes | Form 4 |
| Booth Bruce | Jun 25 | Jun 25 | S | 1,517 | $123.62 | Sale −$187,532 | 535,960 | Yes | Form 4 |
| Booth Bruce | Jun 25 | Jun 25 | S | 1,639 | $124.61 | Sale −$204,236 | 534,321 | Yes | Form 4 |
| Booth Bruce | Jun 25 | Jun 25 | S | 522 | $125.82 | Sale −$65,678 | 533,799 | Yes | Form 4 |
| Booth Bruce | Jun 25 | Jun 25 | S | 223 | $126.71 | Sale −$28,256 | 533,576 | Yes | Form 4 |
| Booth Bruce | Jun 25 | Jun 25 | S | 3,507 | $127.37 | Sale −$446,687 | 530,069 | Yes | Form 4 |
| Booth Bruce | Jun 25 | Jun 25 | S | 305 | $128.69 | Sale −$39,250 | 529,764 | Yes | Form 4 |
| Booth Bruce | Jun 25 | Jun 25 | S | 46 | $129.61 | Sale −$5,962 | 529,718 | Yes | Form 4 |
| Biotechnology Value Trading Fund OS LP | Jun 24 | Jun 25 | A · derivative | 6,068 | $99.87 | $606,011 | 6,068 | No | Form 4 |
| Baker Bros. Advisors (GP) LLC | Jun 24 | Jun 25 | A · derivative | 6,068 | $99.87 | $606,011 | 6,068 | No | Form 4 |
| Baker Bros. Advisors (GP) LLC | Jun 24 | Jun 25 | A · derivative | 6,068 | $99.87 | $606,011 | 6,068 | No | Form 4 |
| Esposito Pamela | Jun 24 | Jun 25 | A · derivative | 6,068 | $99.87 | $606,011 | 6,068 | No | Form 4 |
| Sandor Victor | Jun 24 | Jun 25 | A · derivative | 6,068 | $99.87 | $606,011 | 6,068 | No | Form 4 |
| Albers Jeffrey W. | Jun 24 | Jun 25 | A · derivative | 6,068 | $99.87 | $606,011 | 6,068 | No | Form 4 |
| Maraganore John | Jun 24 | Jun 25 | A · derivative | 6,068 | $99.87 | $606,011 | 6,068 | No | Form 4 |
| Ridloff Elena | Jun 24 | Jun 25 | A · derivative | 6,068 | $99.87 | $606,011 | 6,068 | No | Form 4 |
| Hrustanovic Gorjan | Jun 24 | Jun 25 | A · derivative | 6,068 | $99.87 | $606,011 | 6,068 | No | Form 4 |
| Booth Bruce | Jun 24 | Jun 25 | A · derivative | 6,068 | $99.87 | $606,011 | 6,068 | No | Form 4 |
| Booth Bruce | Jun 24 | Jun 25 | S | 103,688 | $100.42 | Sale −$10,412,349 | 3,357,833 | Yes | Form 4 |
| Booth Bruce | Jun 24 | Jun 25 | S | 14,513 | $100.42 | Sale −$1,457,395 | 599,076 | Yes | Form 4 |
| Booth Bruce | Jun 24 | Jun 25 | S | 14,490 | $101.14 | Sale −$1,465,519 | 3,343,343 | Yes | Form 4 |
| Booth Bruce | Jun 24 | Jun 25 | S | 2,029 | $101.14 | Sale −$205,213 | 597,047 | Yes | Form 4 |
| Booth Bruce | Jun 23 | Jun 25 | S | 1,235 | $99.98 | Sale −$123,475 | 3,461,521 | Yes | Form 4 |
| Booth Bruce | Jun 23 | Jun 25 | S | 173 | $99.98 | Sale −$17,297 | 613,589 | Yes | Form 4 |
| Goodman NoahChief Business Officer | Jun 22 | Jun 22 | M | 2,500 | $21.05 | $52,625 | 52,695.44 | Yes | Form 4 |
| Goodman NoahChief Business Officer | Jun 22 | Jun 22 | S | 2,500 | $99.00 | Sale −$247,500 | 50,195.44 | Yes | Form 4 |
| Goodman NoahChief Business Officer | Jun 22 | Jun 22 | M · derivative | 2,500 | $21.05 | $52,625 | 95,000 | Yes | Form 4 |
| Booth Bruce | Jun 22 | Jun 22 | S | 14,921 | $92.14 | Sale −$1,374,821 | 3,691,811 | Yes | Form 4 |
| Booth Bruce | Jun 22 | Jun 22 | S | 2,035 | $94.48 | Sale −$192,267 | 3,689,776 | Yes | Form 4 |
| Booth Bruce | Jun 22 | Jun 22 | S | 11,783 | $95.12 | Sale −$1,120,799 | 3,677,993 | Yes | Form 4 |
| Booth Bruce | Jun 22 | Jun 22 | S | 20,903 | $96.24 | Sale −$2,011,705 | 3,657,090 | Yes | Form 4 |
| Booth Bruce | Jun 22 | Jun 22 | S | 16,084 | $97.68 | Sale −$1,571,085 | 3,641,006 | Yes | Form 4 |
| Booth Bruce | Jun 22 | Jun 22 | S | 25,976 | $98.58 | Sale −$2,560,714 | 3,615,030 | Yes | Form 4 |
| Booth Bruce | Jun 22 | Jun 22 | S | 52,442 | $99.57 | Sale −$5,221,650 | 3,562,588 | Yes | Form 4 |
| Booth Bruce | Jun 22 | Jun 22 | S | 56,348 | $100.17 | Sale −$5,644,379 | 3,506,240 | Yes | Form 4 |
| Booth Bruce | Jun 22 | Jun 22 | S | 6,597 | $101.61 | Sale −$670,321 | 3,499,643 | Yes | Form 4 |
| Booth Bruce | Jun 22 | Jun 22 | S | 8,990 | $102.48 | Sale −$921,295 | 3,490,653 | Yes | Form 4 |
| Booth Bruce | Jun 22 | Jun 22 | S | 2,179 | $92.14 | Sale −$200,773 | 645,735 | Yes | Form 4 |
| Booth Bruce | Jun 22 | Jun 22 | S | 286 | $94.48 | Sale −$27,021 | 645,449 | Yes | Form 4 |
| Booth Bruce | Jun 22 | Jun 22 | S | 1,648 | $95.12 | Sale −$156,758 | 643,801 | Yes | Form 4 |
| Booth Bruce | Jun 22 | Jun 22 | S | 2,919 | $96.24 | Sale −$280,925 | 640,882 | Yes | Form 4 |
| Booth Bruce | Jun 22 | Jun 22 | S | 2,247 | $97.68 | Sale −$219,487 | 638,635 | Yes | Form 4 |
| Booth Bruce | Jun 22 | Jun 22 | S | 3,603 | $98.58 | Sale −$355,184 | 635,032 | Yes | Form 4 |
| Booth Bruce | Jun 22 | Jun 22 | S | 7,319 | $99.57 | Sale −$728,753 | 627,713 | Yes | Form 4 |
| Booth Bruce | Jun 22 | Jun 22 | S | 7,879 | $100.17 | Sale −$789,239 | 619,834 | Yes | Form 4 |
| Booth Bruce | Jun 22 | Jun 22 | S | 918 | $101.61 | Sale −$93,278 | 618,916 | Yes | Form 4 |
| Booth Bruce | Jun 22 | Jun 22 | S | 1,253 | $102.48 | Sale −$128,407 | 617,663 | Yes | Form 4 |
| Booth Bruce | Jun 22 | Jun 22 | S | 18,313 | $103.42 | Sale −$1,893,930 | 3,472,340 | Yes | Form 4 |
| Booth Bruce | Jun 22 | Jun 22 | S | 9,584 | $104.38 | Sale −$1,000,378 | 3,462,756 | Yes | Form 4 |
| Booth Bruce | Jun 22 | Jun 22 | S | 2,560 | $103.42 | Sale −$264,755 | 615,103 | Yes | Form 4 |
| Booth Bruce | Jun 22 | Jun 22 | S | 1,341 | $104.38 | Sale −$139,974 | 613,762 | Yes | Form 4 |
| Booth Bruce | Jun 18 | Jun 22 | S | 62,897 | $90.48 | Sale −$5,690,921 | 3,744,763 | Yes | Form 4 |
| Booth Bruce | Jun 18 | Jun 22 | S | 32,359 | $91.85 | Sale −$2,972,174 | 3,712,404 | Yes | Form 4 |
| Booth Bruce | Jun 18 | Jun 22 | S | 5,672 | $92.16 | Sale −$522,732 | 3,706,732 | Yes | Form 4 |
| Booth Bruce | Jun 18 | Jun 22 | S | 8,809 | $90.48 | Sale −$797,038 | 653,233 | Yes | Form 4 |
| Booth Bruce | Jun 18 | Jun 22 | S | 4,526 | $91.85 | Sale −$415,713 | 648,707 | Yes | Form 4 |
| Booth Bruce | Jun 18 | Jun 22 | S | 793 | $92.16 | Sale −$73,083 | 647,914 | Yes | Form 4 |
| Booth Bruce | Jun 17 | Jun 22 | M | 11,741 | $20.00 | $234,820 | 11,741 | Yes | Form 4 |
| Booth Bruce | Jun 17 | Jun 22 | S | 11,741 | $89.98 | Sale −$1,056,455 | not reported | Yes | Form 4 |
| Booth Bruce | Jun 17 | Jun 22 | S | 92,169 | $90.38 | Sale −$8,330,234 | 3,807,660 | Yes | Form 4 |
| Booth Bruce | Jun 17 | Jun 22 | S | 12,902 | $90.38 | Sale −$1,166,083 | 662,042 | Yes | Form 4 |
| Booth Bruce | Jun 17 | Jun 22 | M · derivative | 11,741 | $20.00 | $234,820 | 28,127 | Yes | Form 4 |
| Jacobs Bruce N.Chief Financial Officer | Jun 2 | Jun 3 | M | 12,653 | $2.08 | $26,318 | 260,241 | No | Form 4 |
| Jacobs Bruce N.Chief Financial Officer | Jun 2 | Jun 3 | M · derivative | 12,653 | $2.08 | $26,318 | not reported | No | Form 4 |
| Chadwick Jeremy GChief Operating Officer | May 27 | May 27 | S | 3,679 | $81.50 | Sale −$299,839 | 44,618 | Yes | Form 4 |
| Chadwick Jeremy GChief Operating Officer | May 27 | May 27 | S | 600 | $82.08 | Sale −$49,248 | 44,018 | Yes | Form 4 |
| Chadwick Jeremy GChief Operating Officer | May 26 | May 27 | S | 3,730 | $78.36 | Sale −$292,283 | 57,472 | Yes | Form 4 |
| Chadwick Jeremy GChief Operating Officer | May 26 | May 27 | S | 324 | $79.17 | Sale −$25,651 | 57,148 | Yes | Form 4 |
| Chadwick Jeremy GChief Operating Officer | May 26 | May 27 | S | 3,800 | $79.39 | Sale −$301,682 | 53,348 | Yes | Form 4 |
| Chadwick Jeremy GChief Operating Officer | May 26 | May 27 | S | 4,500 | $80.02 | Sale −$360,090 | 48,848 | Yes | Form 4 |
| Chadwick Jeremy GChief Operating Officer | May 26 | May 27 | S | 551 | $80.71 | Sale −$44,471 | 48,297 | Yes | Form 4 |
| Esposito Pamela | May 19 | May 19 | M | 1,000 | $31.20 | $31,200 | 1,000 | No | Form 4 |
| Esposito Pamela | May 19 | May 19 | M · derivative | 1,000 | $31.20 | $31,200 | 9,000 | No | Form 4 |
| Jacobs Bruce N.Chief Financial Officer | May 18 | May 19 | M | 15,000 | $2.08 | $31,200 | 247,588 | No | Form 4 |
| Jacobs Bruce N.Chief Financial Officer | May 18 | May 19 | M · derivative | 15,000 | $2.08 | $31,200 | 12,653 | No | Form 4 |
| Ridloff Elena | May 11 | May 11 | M | 3,000 | $31.20 | $93,600 | 3,000 | Yes | Form 4 |
| Ridloff Elena | May 11 | May 11 | S | 3,000 | $87.00 | Sale −$261,000 | not reported | Yes | Form 4 |
| Ridloff Elena | May 11 | May 11 | M · derivative | 3,000 | $31.20 | $93,600 | 13,000 | Yes | Form 4 |
| Mainolfi NelloChief Executive Officer | Apr 29 | Apr 29 | M | 30,000 | $2.08 | $62,400 | 696,195 | Yes | Form 4 |
| Mainolfi NelloChief Executive Officer | Apr 29 | Apr 29 | S | 17,005 | $80.74 | Sale −$1,372,984 | 679,190 | Yes | Form 4 |
| Mainolfi NelloChief Executive Officer | Apr 29 | Apr 29 | S | 12,059 | $81.70 | Sale −$985,220 | 667,131 | Yes | Form 4 |
| Mainolfi NelloChief Executive Officer | Apr 29 | Apr 29 | S | 936 | $82.45 | Sale −$77,173 | 666,195 | Yes | Form 4 |
| Mainolfi NelloChief Executive Officer | Apr 29 | Apr 29 | M · derivative | 30,000 | $2.08 | $62,400 | 215,559 | Yes | Form 4 |
| Chadwick Jeremy GChief Operating Officer | Apr 22 | Apr 24 | M | 100 | $30.17 | $3,017 | 61,302 | Yes | Form 4 |
| Chadwick Jeremy GChief Operating Officer | Apr 22 | Apr 24 | M | 200 | $43.50 | $8,700 | 61,502 | Yes | Form 4 |
| Chadwick Jeremy GChief Operating Officer | Apr 22 | Apr 24 | S | 300 | $90.00 | Sale −$27,000 | 61,202 | Yes | Form 4 |
| Chadwick Jeremy GChief Operating Officer | Apr 22 | Apr 24 | M · derivative | 100 | $30.17 | $3,017 | 45,434 | Yes | Form 4 |
| Chadwick Jeremy GChief Operating Officer | Apr 22 | Apr 24 | M · derivative | 200 | $43.50 | $8,700 | 58,263 | Yes | Form 4 |
| Booth Bruce | Apr 22 | Apr 24 | M | 5,641 | $14.18 | $79,989 | 5,641 | Yes | Form 4 |
| Booth Bruce | Apr 22 | Apr 24 | M | 259 | $20.00 | $5,180 | 5,900 | Yes | Form 4 |
| Booth Bruce | Apr 22 | Apr 24 | S | 5,900 | $89.96 | Sale −$530,764 | not reported | Yes | Form 4 |
| Booth Bruce | Apr 22 | Apr 24 | S | 88 | $90.08 | Sale −$7,927 | 3,899,829 | Yes | Form 4 |
| Booth Bruce | Apr 22 | Apr 24 | S | 12 | $90.08 | Sale −$1,081 | 674,944 | Yes | Form 4 |
| Booth Bruce | Apr 22 | Apr 24 | M · derivative | 5,641 | $14.18 | $79,989 | not reported | Yes | Form 4 |
| Booth Bruce | Apr 22 | Apr 24 | M · derivative | 259 | $20.00 | $5,180 | 39,868 | Yes | Form 4 |
| Chadwick Jeremy GChief Operating Officer | Apr 15 | Apr 16 | M | 1,300 | $43.50 | $56,550 | 62,502 | Yes | Form 4 |
| Chadwick Jeremy GChief Operating Officer | Apr 15 | Apr 16 | S | 1,300 | $90.00 | Sale −$117,000 | 61,202 | Yes | Form 4 |
| Chadwick Jeremy GChief Operating Officer | Apr 15 | Apr 16 | M · derivative | 1,300 | $43.50 | $56,550 | 58,463 | Yes | Form 4 |
| Booth Bruce | Apr 15 | Apr 16 | M | 2,200 | $14.18 | $31,196 | 2,200 | Yes | Form 4 |
| Booth Bruce | Apr 15 | Apr 16 | S | 2,200 | $89.95 | Sale −$197,890 | not reported | Yes | Form 4 |
| Booth Bruce | Apr 15 | Apr 16 | S | 2,750 | $90.10 | Sale −$247,775 | 3,899,917 | Yes | Form 4 |
| Booth Bruce | Apr 15 | Apr 16 | S | 385 | $90.10 | Sale −$34,689 | 674,956 | Yes | Form 4 |
| Booth Bruce | Apr 15 | Apr 16 | M · derivative | 2,200 | $14.18 | $31,196 | 5,641 | Yes | Form 4 |
| Chadwick Jeremy GChief Operating Officer | Apr 14 | Apr 16 | M | 4,466 | $30.17 | $134,739 | 65,668 | Yes | Form 4 |
| Chadwick Jeremy GChief Operating Officer | Apr 14 | Apr 16 | M | 785 | $43.50 | $34,148 | 66,453 | Yes | Form 4 |
| Chadwick Jeremy GChief Operating Officer | Apr 14 | Apr 16 | S | 5,251 | $90.00 | Sale −$472,590 | 61,202 | Yes | Form 4 |
| Chadwick Jeremy GChief Operating Officer | Apr 14 | Apr 16 | M · derivative | 4,466 | $30.17 | $134,739 | 45,534 | Yes | Form 4 |
| Chadwick Jeremy GChief Operating Officer | Apr 14 | Apr 16 | M · derivative | 785 | $43.50 | $34,148 | 59,763 | Yes | Form 4 |
| Goodman NoahChief Business Officer | Apr 14 | Apr 16 | S | 1,347 | $90.00 | Sale −$121,230 | 50,195.44 | Yes | Form 4 |
| Booth Bruce | Apr 14 | Apr 16 | M | 4,159 | $14.18 | $58,975 | 4,159 | Yes | Form 4 |
| Booth Bruce | Apr 14 | Apr 16 | S | 4,159 | $89.97 | Sale −$374,185 | not reported | Yes | Form 4 |
| Booth Bruce | Apr 14 | Apr 16 | M · derivative | 4,159 | $14.18 | $58,975 | 7,841 | Yes | Form 4 |
| Goodman NoahChief Business Officer | Apr 10 | Apr 10 | S | 2,000 | $87.35 | Sale −$174,700 | 51,542.44 | Yes | Form 4 |
| Goodman NoahChief Business Officer | Apr 9 | Apr 10 | M | 2,500 | $21.05 | $52,625 | 61,806.44 | Yes | Form 4 |
| Goodman NoahChief Business Officer | Apr 9 | Apr 10 | S | 3,094 | $86.62 | Sale −$268,002 | 58,712.44 | Yes | Form 4 |
| Goodman NoahChief Business Officer | Apr 9 | Apr 10 | S | 2,670 | $87.11 | Sale −$232,584 | 56,042.44 | Yes | Form 4 |
| Goodman NoahChief Business Officer | Apr 9 | Apr 10 | S | 2,500 | $89.00 | Sale −$222,500 | 53,542.44 | Yes | Form 4 |
| Goodman NoahChief Business Officer | Apr 9 | Apr 10 | M · derivative | 2,500 | $21.05 | $52,625 | 97,500 | Yes | Form 4 |
| Chadwick Jeremy GChief Operating Officer | Apr 1 | Apr 1 | M | 14,640 | $29.64 | $433,930 | 75,842 | Yes | Form 4 |
| Chadwick Jeremy GChief Operating Officer | Apr 1 | Apr 1 | S | 13,540 | $85.41 | Sale −$1,156,451 | 62,302 | Yes | Form 4 |
| Chadwick Jeremy GChief Operating Officer | Apr 1 | Apr 1 | S | 1,100 | $86.05 | Sale −$94,655 | 61,202 | Yes | Form 4 |
| Chadwick Jeremy GChief Operating Officer | Apr 1 | Apr 1 | M · derivative | 14,640 | $29.64 | $433,930 | 68,633 | Yes | Form 4 |
| Ridloff Elena | Apr 1 | Apr 1 | M | 4,600 | $14.18 | $65,228 | 4,600 | Yes | Form 4 |
| Ridloff Elena | Apr 1 | Apr 1 | S | 3,400 | $85.19 | Sale −$289,646 | 1,200 | Yes | Form 4 |
| Ridloff Elena | Apr 1 | Apr 1 | S | 1,200 | $86.05 | Sale −$103,260 | not reported | Yes | Form 4 |
| Ridloff Elena | Apr 1 | Apr 1 | M · derivative | 4,600 | $14.18 | $65,228 | not reported | Yes | Form 4 |
| Chadwick Jeremy GChief Operating Officer | Mar 31 | Apr 1 | M | 7,600 | $29.64 | $225,264 | 68,802 | Yes | Form 4 |
| Chadwick Jeremy GChief Operating Officer | Mar 31 | Apr 1 | S | 7,600 | $85.38 | Sale −$648,888 | 61,202 | Yes | Form 4 |
| Chadwick Jeremy GChief Operating Officer | Mar 31 | Apr 1 | M · derivative | 7,600 | $29.64 | $225,264 | 83,273 | Yes | Form 4 |
| Ridloff Elena | Mar 31 | Apr 1 | M | 7,400 | $14.18 | $104,932 | 7,400 | Yes | Form 4 |
| Ridloff Elena | Mar 31 | Apr 1 | S | 7,400 | $85.37 | Sale −$631,738 | not reported | Yes | Form 4 |
| Ridloff Elena | Mar 31 | Apr 1 | M · derivative | 7,400 | $14.18 | $104,932 | 4,600 | Yes | Form 4 |
| Chadwick Jeremy GChief Operating Officer | Mar 25 | Mar 25 | M | 24,727 | $29.64 | $732,908 | 85,929 | Yes | Form 4 |
| Chadwick Jeremy GChief Operating Officer | Mar 25 | Mar 25 | S | 24,727 | $80.26 | Sale −$1,984,589 | 61,202 | Yes | Form 4 |
| Chadwick Jeremy GChief Operating Officer | Mar 25 | Mar 25 | M · derivative | 24,727 | $29.64 | $732,908 | 90,873 | Yes | Form 4 |
| Chadwick Jeremy GChief Operating Officer | Mar 23 | Mar 25 | M | 84,400 | $29.64 | $2,501,616 | 152,452 | Yes | Form 4 |
| Chadwick Jeremy GChief Operating Officer | Mar 23 | Mar 25 | S | 22,756 | $76.73 | Sale −$1,746,068 | 129,696 | Yes | Form 4 |
| Chadwick Jeremy GChief Operating Officer | Mar 23 | Mar 25 | S | 52,975 | $77.21 | Sale −$4,090,200 | 76,721 | Yes | Form 4 |
| Chadwick Jeremy GChief Operating Officer | Mar 23 | Mar 25 | S | 8,214 | $78.40 | Sale −$643,978 | 68,507 | Yes | Form 4 |
| Chadwick Jeremy GChief Operating Officer | Mar 23 | Mar 25 | S | 6,105 | $79.87 | Sale −$487,606 | 62,402 | Yes | Form 4 |
| Chadwick Jeremy GChief Operating Officer | Mar 23 | Mar 25 | S | 1,200 | $80.05 | Sale −$96,060 | 61,202 | Yes | Form 4 |
| Chadwick Jeremy GChief Operating Officer | Mar 23 | Mar 25 | M · derivative | 84,400 | $29.64 | $2,501,616 | 115,600 | Yes | Form 4 |
| Esposito Pamela | Mar 20 | Mar 20 | M | 2,500 | $49.10 | $122,750 | 2,500 | Yes | Form 4 |
| Esposito Pamela | Mar 20 | Mar 20 | S | 700 | $77.71 | Sale −$54,397 | 1,800 | Yes | Form 4 |
| Esposito Pamela | Mar 20 | Mar 20 | S | 600 | $79.24 | Sale −$47,544 | 1,200 | Yes | Form 4 |
| Esposito Pamela | Mar 20 | Mar 20 | S | 1,200 | $79.94 | Sale −$95,928 | not reported | Yes | Form 4 |
| Esposito Pamela | Mar 20 | Mar 20 | M · derivative | 2,500 | $49.10 | $122,750 | not reported | Yes | Form 4 |
| Chadwick Jeremy GChief Operating Officer | Mar 11 | Mar 11 | M | 20,000 | $43.50 | $870,000 | 93,810 | Yes | Form 4 |
| Chadwick Jeremy GChief Operating Officer | Mar 11 | Mar 11 | S | 1,765 | $82.13 | Sale −$144,959 | 92,045 | Yes | Form 4 |
| Chadwick Jeremy GChief Operating Officer | Mar 11 | Mar 11 | S | 12,882 | $83.10 | Sale −$1,070,494 | 79,163 | Yes | Form 4 |
| Chadwick Jeremy GChief Operating Officer | Mar 11 | Mar 11 | S | 11,111 | $83.72 | Sale −$930,213 | 68,052 | Yes | Form 4 |
| Chadwick Jeremy GChief Operating Officer | Mar 11 | Mar 11 | M · derivative | 20,000 | $43.50 | $870,000 | 60,548 | Yes | Form 4 |
| Jacobs Bruce N.Chief Financial Officer | Mar 4 | Mar 4 | S | 492 | $84.00 | Sale −$41,328 | 236,991 | No | Form 4 |
| Jacobs Bruce N.Chief Financial Officer | Mar 4 | Mar 4 | S | 2,519 | $85.04 | Sale −$214,216 | 234,472 | No | Form 4 |
| Jacobs Bruce N.Chief Financial Officer | Mar 4 | Mar 4 | S | 1,437 | $85.78 | Sale −$123,266 | 233,035 | No | Form 4 |
| Jacobs Bruce N.Chief Financial Officer | Mar 4 | Mar 4 | S | 447 | $86.62 | Sale −$38,719 | 232,588 | No | Form 4 |
| Gollob JaredChief Medical Officer | Mar 4 | Mar 4 | S | 492 | $84.00 | Sale −$41,328 | 121,537 | No | Form 4 |
| Gollob JaredChief Medical Officer | Mar 4 | Mar 4 | S | 2,519 | $85.04 | Sale −$214,216 | 119,018 | No | Form 4 |
| Gollob JaredChief Medical Officer | Mar 4 | Mar 4 | S | 1,437 | $85.78 | Sale −$123,266 | 117,581 | No | Form 4 |
| Gollob JaredChief Medical Officer | Mar 4 | Mar 4 | S | 447 | $86.62 | Sale −$38,719 | 117,134 | No | Form 4 |
| Chadwick Jeremy GChief Operating Officer | Mar 4 | Mar 4 | S | 394 | $84.00 | Sale −$33,096 | 77,335 | No | Form 4 |
| Chadwick Jeremy GChief Operating Officer | Mar 4 | Mar 4 | S | 2,017 | $85.04 | Sale −$171,526 | 75,318 | No | Form 4 |
| Chadwick Jeremy GChief Operating Officer | Mar 4 | Mar 4 | S | 1,150 | $85.78 | Sale −$98,647 | 74,168 | No | Form 4 |
| Chadwick Jeremy GChief Operating Officer | Mar 4 | Mar 4 | S | 358 | $86.62 | Sale −$31,010 | 73,810 | No | Form 4 |
| Mainolfi NelloChief Executive Officer | Mar 2 | Mar 4 | A · derivative | 215,000 | $90.10 | $19,371,500 | 215,000 | No | Form 4 |
| Jacobs Bruce N.Chief Financial Officer | Mar 2 | Mar 4 | A | 17,650 | $0.00 | $0 | 245,059 | No | Form 4 |
| Jacobs Bruce N.Chief Financial Officer | Mar 2 | Mar 4 | S | 2,039 | $87.75 | Sale −$178,922 | 243,020 | No | Form 4 |
| Jacobs Bruce N.Chief Financial Officer | Mar 2 | Mar 4 | S | 1,424 | $88.50 | Sale −$126,024 | 241,596 | No | Form 4 |
| Jacobs Bruce N.Chief Financial Officer | Mar 2 | Mar 4 | S | 4,113 | $89.66 | Sale −$368,772 | 237,483 | No | Form 4 |
| Jacobs Bruce N.Chief Financial Officer | Mar 2 | Mar 4 | A · derivative | 35,300 | $90.10 | $3,180,530 | 35,300 | No | Form 4 |
| Gollob JaredChief Medical Officer | Mar 2 | Mar 4 | A | 17,650 | $0.00 | $0 | 127,642 | No | Form 4 |
| Gollob JaredChief Medical Officer | Mar 2 | Mar 4 | S | 1,510 | $87.75 | Sale −$132,503 | 126,132 | No | Form 4 |
| Gollob JaredChief Medical Officer | Mar 2 | Mar 4 | S | 1,055 | $88.50 | Sale −$93,368 | 125,077 | No | Form 4 |
| Gollob JaredChief Medical Officer | Mar 2 | Mar 4 | S | 3,048 | $89.66 | Sale −$273,284 | 122,029 | No | Form 4 |
| Gollob JaredChief Medical Officer | Mar 2 | Mar 4 | A · derivative | 35,300 | $90.10 | $3,180,530 | 35,300 | No | Form 4 |
| Goodman NoahChief Business Officer | Mar 2 | Mar 4 | A | 9,225 | $0.00 | $0 | 59,306.44 | No | Form 4 |
| Goodman NoahChief Business Officer | Mar 2 | Mar 4 | A · derivative | 18,450 | $90.10 | $1,662,345 | 18,450 | No | Form 4 |
| Chadwick Jeremy GChief Operating Officer | Mar 2 | Mar 4 | A | 12,575 | $0.00 | $0 | 79,768 | No | Form 4 |
| Chadwick Jeremy GChief Operating Officer | Mar 2 | Mar 4 | S | 549 | $87.75 | Sale −$48,175 | 79,219 | No | Form 4 |
| Chadwick Jeremy GChief Operating Officer | Mar 2 | Mar 4 | S | 383 | $88.50 | Sale −$33,896 | 78,836 | No | Form 4 |
| Chadwick Jeremy GChief Operating Officer | Mar 2 | Mar 4 | S | 1,107 | $89.66 | Sale −$99,254 | 77,729 | No | Form 4 |
| Chadwick Jeremy GChief Operating Officer | Mar 2 | Mar 4 | A · derivative | 25,150 | $90.10 | $2,266,015 | 25,150 | No | Form 4 |
| Adams BrianChief Legal Officer | Mar 2 | Mar 4 | A | 4,125 | $0.00 | $0 | 56,625 | No | Form 4 |
| Adams BrianChief Legal Officer | Mar 2 | Mar 4 | A · derivative | 8,250 | $90.10 | $743,325 | 8,250 | No | Form 4 |
| Booth Bruce | Mar 2 | Mar 4 | S | 71,814 | $90.13 | Sale −$6,472,596 | 3,902,667 | Yes | Form 4 |
| Booth Bruce | Mar 2 | Mar 4 | S | 10,052 | $90.13 | Sale −$905,987 | 675,341 | Yes | Form 4 |
| Mainolfi NelloChief Executive Officer | Feb 25 | Feb 25 | M | 30,000 | $2.08 | $62,400 | 696,195 | Yes | Form 4 |
| Mainolfi NelloChief Executive Officer | Feb 25 | Feb 25 | S | 19,764 | $89.78 | Sale −$1,774,412 | 676,431 | Yes | Form 4 |
| Mainolfi NelloChief Executive Officer | Feb 25 | Feb 25 | S | 5,434 | $90.39 | Sale −$491,179 | 670,997 | Yes | Form 4 |
| Mainolfi NelloChief Executive Officer | Feb 25 | Feb 25 | S | 3,293 | $91.76 | Sale −$302,166 | 667,704 | Yes | Form 4 |
| Mainolfi NelloChief Executive Officer | Feb 25 | Feb 25 | S | 1,501 | $92.81 | Sale −$139,308 | 666,203 | Yes | Form 4 |
| Mainolfi NelloChief Executive Officer | Feb 25 | Feb 25 | S | 8 | $93.49 | Sale −$748 | 666,195 | Yes | Form 4 |
| Mainolfi NelloChief Executive Officer | Feb 25 | Feb 25 | M · derivative | 30,000 | $2.08 | $62,400 | 245,559 | Yes | Form 4 |
| Esposito Pamela | Feb 20 | Feb 20 | M | 2,500 | $49.10 | $122,750 | 2,500 | Yes | Form 4 |
| Esposito Pamela | Feb 20 | Feb 20 | S | 1,900 | $87.06 | Sale −$165,414 | 600 | Yes | Form 4 |
| Esposito Pamela | Feb 20 | Feb 20 | S | 600 | $88.10 | Sale −$52,860 | not reported | Yes | Form 4 |
| Esposito Pamela | Feb 20 | Feb 20 | M · derivative | 2,500 | $49.10 | $122,750 | 2,500 | Yes | Form 4 |
| Esposito Pamela | Jan 20 | Jan 20 | M | 3,000 | $31.20 | $93,600 | 3,000 | Yes | Form 4 |
| Esposito Pamela | Jan 20 | Jan 20 | M | 2,500 | $49.10 | $122,750 | 5,500 | Yes | Form 4 |
| Esposito Pamela | Jan 20 | Jan 20 | S | 400 | $66.68 | Sale −$26,672 | 5,100 | Yes | Form 4 |
| Esposito Pamela | Jan 20 | Jan 20 | S | 4,900 | $67.99 | Sale −$333,151 | 200 | Yes | Form 4 |
| Esposito Pamela | Jan 20 | Jan 20 | S | 200 | $68.52 | Sale −$13,704 | not reported | Yes | Form 4 |
| Esposito Pamela | Jan 20 | Jan 20 | M · derivative | 3,000 | $31.20 | $93,600 | 10,000 | Yes | Form 4 |
| Esposito Pamela | Jan 20 | Jan 20 | M · derivative | 2,500 | $49.10 | $122,750 | 5,000 | Yes | Form 4 |
| Mainolfi NelloChief Executive Officer | Jan 5 | Jan 6 | M | 3,118 | $32.07 | $99,994 | 666,195 | No | Form 4 |
| Mainolfi NelloChief Executive Officer | Jan 5 | Jan 6 | M · derivative | 3,118 | $32.07 | $99,994 | 446,882 | No | Form 4 |
| Mainolfi NelloChief Executive Officer | Dec 31, 2025 | Dec 31, 2025 | M | 30,000 | $2.08 | $62,400 | 693,077 | Yes | Form 4 |
| Mainolfi NelloChief Executive Officer | Dec 31, 2025 | Dec 31, 2025 | S | 23,986 | $77.95 | Sale −$1,869,709 | 669,091 | Yes | Form 4 |
| Mainolfi NelloChief Executive Officer | Dec 31, 2025 | Dec 31, 2025 | S | 6,014 | $78.52 | Sale −$472,219 | 663,077 | Yes | Form 4 |
| Mainolfi NelloChief Executive Officer | Dec 31, 2025 | Dec 31, 2025 | M · derivative | 30,000 | $2.08 | $62,400 | 275,559 | Yes | Form 4 |
| Esposito Pamela | Dec 17, 2025 | Dec 17, 2025 | M | 12,563 | $49.10 | $616,843 | 12,563 | Yes | Form 4 |
| Esposito Pamela | Dec 17, 2025 | Dec 17, 2025 | M | 12,000 | $27.67 | $332,040 | 24,563 | Yes | Form 4 |
| Esposito Pamela | Dec 17, 2025 | Dec 17, 2025 | M | 3,000 | $31.20 | $93,600 | 27,563 | Yes | Form 4 |
| Esposito Pamela | Dec 17, 2025 | Dec 17, 2025 | S | 14,505 | $81.56 | Sale −$1,183,028 | 13,058 | Yes | Form 4 |
| Esposito Pamela | Dec 17, 2025 | Dec 17, 2025 | S | 7,959 | $82.34 | Sale −$655,344 | 5,099 | Yes | Form 4 |
| Esposito Pamela | Dec 17, 2025 | Dec 17, 2025 | S | 4,099 | $83.45 | Sale −$342,062 | 1,000 | Yes | Form 4 |
| Esposito Pamela | Dec 17, 2025 | Dec 17, 2025 | S | 1,000 | $84.07 | Sale −$84,070 | not reported | Yes | Form 4 |
| Esposito Pamela | Dec 17, 2025 | Dec 17, 2025 | M · derivative | 12,563 | $49.10 | $616,843 | 7,500 | Yes | Form 4 |
| Esposito Pamela | Dec 17, 2025 | Dec 17, 2025 | M · derivative | 12,000 | $27.67 | $332,040 | not reported | Yes | Form 4 |
| Esposito Pamela | Dec 17, 2025 | Dec 17, 2025 | M · derivative | 3,000 | $31.20 | $93,600 | 13,000 | Yes | Form 4 |
| Mainolfi NelloChief Executive Officer | Dec 17, 2025 | Dec 17, 2025 | M | 2,595 | $38.53 | $99,985 | 663,077 | No | Form 4 |
| Mainolfi NelloChief Executive Officer | Dec 17, 2025 | Dec 17, 2025 | M · derivative | 2,595 | $38.53 | $99,985 | 272,505 | No | Form 4 |
| Booth Bruce | Dec 12, 2025 | Dec 12, 2025 | S | 570 | $91.04 | Sale −$51,893 | 3,974,481 | No | Form 4 |
| Booth Bruce | Dec 12, 2025 | Dec 12, 2025 | S | 108 | $91.04 | Sale −$9,832 | 685,393 | No | Form 4 |
| Booth Bruce | Dec 11, 2025 | Dec 12, 2025 | S | 5,125 | $91.23 | Sale −$467,554 | 3,975,051 | No | Form 4 |
| Booth Bruce | Dec 11, 2025 | Dec 12, 2025 | S | 976 | $91.23 | Sale −$89,040 | 685,501 | No | Form 4 |
| Booth Bruce | Dec 10, 2025 | Dec 12, 2025 | S | 31,459 | $88.64 | Sale −$2,788,526 | 4,141,757 | No | Form 4 |
| Booth Bruce | Dec 10, 2025 | Dec 12, 2025 | S | 17,825 | $89.25 | Sale −$1,590,881 | 4,123,932 | No | Form 4 |
| Booth Bruce | Dec 10, 2025 | Dec 12, 2025 | S | 10,545 | $90.14 | Sale −$950,526 | 4,113,387 | No | Form 4 |
| Booth Bruce | Dec 10, 2025 | Dec 12, 2025 | S | 47,349 | $92.41 | Sale −$4,375,521 | 4,066,038 | No | Form 4 |
| Booth Bruce | Dec 10, 2025 | Dec 12, 2025 | S | 85,862 | $93.20 | Sale −$8,002,338 | 3,980,176 | No | Form 4 |
| Booth Bruce | Dec 10, 2025 | Dec 12, 2025 | S | 5,979 | $88.64 | Sale −$529,979 | 717,267 | No | Form 4 |
| Booth Bruce | Dec 10, 2025 | Dec 12, 2025 | S | 3,391 | $89.25 | Sale −$302,647 | 713,876 | No | Form 4 |
| Booth Bruce | Dec 10, 2025 | Dec 12, 2025 | S | 2,001 | $90.14 | Sale −$180,370 | 711,875 | No | Form 4 |
| Booth Bruce | Dec 10, 2025 | Dec 12, 2025 | S | 9,060 | $92.41 | Sale −$837,235 | 702,815 | No | Form 4 |
| Booth Bruce | Dec 10, 2025 | Dec 12, 2025 | S | 16,338 | $93.20 | Sale −$1,522,702 | 686,477 | No | Form 4 |
| Baker Felix | Dec 11, 2025 | Dec 11, 2025 | P | 167,192 | $86.00 | Purchase +$14,378,512 | 701,326 | No | Form 4 |
| Baker Felix | Dec 11, 2025 | Dec 11, 2025 | P | 1,838,621 | $86.00 | Purchase +$158,121,406 | 7,955,916 | No | Form 4 |
| Gollob JaredChief Medical Officer | Dec 8, 2025 | Dec 8, 2025 | M | 49,307 | $5.33 | $262,806 | 159,299 | Yes | Form 4 |
| Gollob JaredChief Medical Officer | Dec 8, 2025 | Dec 8, 2025 | S | 13,759 | $87.37 | Sale −$1,202,124 | 145,540 | Yes | Form 4 |
| Gollob JaredChief Medical Officer | Dec 8, 2025 | Dec 8, 2025 | S | 18,357 | $88.02 | Sale −$1,615,783 | 127,183 | Yes | Form 4 |
| Gollob JaredChief Medical Officer | Dec 8, 2025 | Dec 8, 2025 | S | 3,929 | $89.43 | Sale −$351,370 | 123,254 | Yes | Form 4 |
| Gollob JaredChief Medical Officer | Dec 8, 2025 | Dec 8, 2025 | S | 8,562 | $90.12 | Sale −$771,607 | 114,692 | Yes | Form 4 |
| Gollob JaredChief Medical Officer | Dec 8, 2025 | Dec 8, 2025 | S | 3,300 | $91.46 | Sale −$301,818 | 111,392 | Yes | Form 4 |
| Gollob JaredChief Medical Officer | Dec 8, 2025 | Dec 8, 2025 | S | 1,400 | $92.19 | Sale −$129,066 | 109,992 | Yes | Form 4 |
| Gollob JaredChief Medical Officer | Dec 8, 2025 | Dec 8, 2025 | M · derivative | 49,307 | $5.33 | $262,806 | 34,083 | Yes | Form 4 |
| Mainolfi NelloChief Executive Officer | Dec 8, 2025 | Dec 8, 2025 | M | 100,000 | $2.08 | $208,000 | 760,482 | Yes | Form 4 |
| Mainolfi NelloChief Executive Officer | Dec 8, 2025 | Dec 8, 2025 | S | 100,000 | $89.17 | Sale −$8,917,000 | 660,482 | Yes | Form 4 |
| Mainolfi NelloChief Executive Officer | Dec 8, 2025 | Dec 8, 2025 | M · derivative | 100,000 | $2.08 | $208,000 | 305,559 | Yes | Form 4 |
| Albers Jeffrey W. | Dec 8, 2025 | Dec 8, 2025 | M | 5,000 | $14.18 | $70,900 | 5,000 | Yes | Form 4 |
| Albers Jeffrey W. | Dec 8, 2025 | Dec 8, 2025 | S | 2,748 | $89.32 | Sale −$245,451 | 2,252 | Yes | Form 4 |
| Albers Jeffrey W. | Dec 8, 2025 | Dec 8, 2025 | S | 2,252 | $90.30 | Sale −$203,356 | not reported | Yes | Form 4 |
| Albers Jeffrey W. | Dec 8, 2025 | Dec 8, 2025 | M · derivative | 5,000 | $14.18 | $70,900 | 7,000 | Yes | Form 4 |
| Mainolfi NelloChief Executive Officer | Oct 29, 2025 | Oct 29, 2025 | M | 30,000 | $2.08 | $62,400 | 690,482 | Yes | Form 4 |
| Mainolfi NelloChief Executive Officer | Oct 29, 2025 | Oct 29, 2025 | S | 1,862 | $59.72 | Sale −$111,199 | 688,620 | Yes | Form 4 |
| Mainolfi NelloChief Executive Officer | Oct 29, 2025 | Oct 29, 2025 | S | 24,511 | $61.02 | Sale −$1,495,661 | 664,109 | Yes | Form 4 |
| Mainolfi NelloChief Executive Officer | Oct 29, 2025 | Oct 29, 2025 | S | 3,627 | $61.46 | Sale −$222,915 | 660,482 | Yes | Form 4 |
| Mainolfi NelloChief Executive Officer | Oct 29, 2025 | Oct 29, 2025 | M · derivative | 30,000 | $2.08 | $62,400 | 405,559 | Yes | Form 4 |
| Gollob JaredChief Medical Officer | Oct 15, 2025 | Oct 15, 2025 | M | 28,999 | $1.31 | $37,989 | 147,358 | Yes | Form 4 |
| Gollob JaredChief Medical Officer | Oct 15, 2025 | Oct 15, 2025 | M | 22,210 | $2.08 | $46,197 | 169,568 | Yes | Form 4 |
| Gollob JaredChief Medical Officer | Oct 15, 2025 | Oct 15, 2025 | S | 29,264 | $60.37 | Sale −$1,766,668 | 140,304 | Yes | Form 4 |
| Gollob JaredChief Medical Officer | Oct 15, 2025 | Oct 15, 2025 | S | 8,963 | $61.49 | Sale −$551,135 | 131,341 | Yes | Form 4 |
| Gollob JaredChief Medical Officer | Oct 15, 2025 | Oct 15, 2025 | S | 14,896 | $62.72 | Sale −$934,277 | 116,445 | Yes | Form 4 |
| Gollob JaredChief Medical Officer | Oct 15, 2025 | Oct 15, 2025 | S | 6,453 | $63.09 | Sale −$407,120 | 109,992 | Yes | Form 4 |
| Gollob JaredChief Medical Officer | Oct 15, 2025 | Oct 15, 2025 | M · derivative | 28,999 | $1.31 | $37,989 | not reported | Yes | Form 4 |
| Gollob JaredChief Medical Officer | Oct 15, 2025 | Oct 15, 2025 | M · derivative | 22,210 | $2.08 | $46,197 | not reported | Yes | Form 4 |
| Albers Jeffrey W. | Oct 13, 2025 | Oct 14, 2025 | M | 5,000 | $10.34 | $51,700 | 5,000 | Yes | Form 4 |
| Albers Jeffrey W. | Oct 13, 2025 | Oct 14, 2025 | S | 5,000 | $59.19 | Sale −$295,950 | not reported | Yes | Form 4 |
| Albers Jeffrey W. | Oct 13, 2025 | Oct 14, 2025 | M · derivative | 5,000 | $10.34 | $51,700 | not reported | Yes | Form 4 |
| Gollob JaredChief Medical Officer | Oct 13, 2025 | Oct 14, 2025 | M | 800 | $1.31 | $1,048 | 120,800 | Yes | Form 4 |
| Gollob JaredChief Medical Officer | Oct 13, 2025 | Oct 14, 2025 | M | 673 | $2.08 | $1,400 | 121,473 | Yes | Form 4 |
| Gollob JaredChief Medical Officer | Oct 13, 2025 | Oct 14, 2025 | S | 3,114 | $60.00 | Sale −$186,840 | 118,359 | Yes | Form 4 |
| Gollob JaredChief Medical Officer | Oct 13, 2025 | Oct 14, 2025 | M · derivative | 800 | $1.31 | $1,048 | 28,999 | Yes | Form 4 |
| Gollob JaredChief Medical Officer | Oct 13, 2025 | Oct 14, 2025 | M · derivative | 673 | $2.08 | $1,400 | 22,210 | Yes | Form 4 |
| Jacobs Bruce N.Chief Financial Officer | Sep 17, 2025 | Sep 17, 2025 | M | 79,220 | $2.08 | $164,778 | 306,629 | Yes | Form 4 |
| Jacobs Bruce N.Chief Financial Officer | Sep 17, 2025 | Sep 17, 2025 | S | 79,220 | $50.00 | Sale −$3,961,000 | 227,409 | Yes | Form 4 |
| Jacobs Bruce N.Chief Financial Officer | Sep 17, 2025 | Sep 17, 2025 | M · derivative | 42,246 | $2.08 | $87,872 | 27,653 | Yes | Form 4 |
| Jacobs Bruce N.Chief Financial Officer | Sep 17, 2025 | Sep 17, 2025 | M · derivative | 36,974 | $2.08 | $76,906 | not reported | Yes | Form 4 |
| Mainolfi NelloChief Executive Officer | Sep 16, 2025 | Sep 16, 2025 | M | 30,000 | $2.08 | $62,400 | 690,482 | Yes | Form 4 |
| Mainolfi NelloChief Executive Officer | Sep 16, 2025 | Sep 16, 2025 | S | 30,000 | $49.00 | Sale −$1,470,000 | 660,482 | Yes | Form 4 |
| Mainolfi NelloChief Executive Officer | Sep 16, 2025 | Sep 16, 2025 | M · derivative | 30,000 | $2.08 | $62,400 | 435,559 | Yes | Form 4 |
| Adams BrianChief Legal Officer | Sep 3, 2025 | Sep 3, 2025 | A | 52,500 | $0.00 | $0 | 52,500 | No | Form 4 |
| Adams BrianChief Legal Officer | Sep 3, 2025 | Sep 3, 2025 | A · derivative | 105,000 | $43.30 | $4,546,500 | 105,000 | No | Form 4 |
| Biotechnology Value Trading Fund OS LP | Jun 30, 2025 | Jul 1, 2025 | P | 142,604 | $44.00 | Purchase +$6,274,576 | 2,798,795 | No | Form 4 |
| Biotechnology Value Trading Fund OS LP | Jun 30, 2025 | Jul 1, 2025 | P | 115,783 | $44.00 | Purchase +$5,094,452 | 2,219,858 | No | Form 4 |
| Biotechnology Value Trading Fund OS LP | Jun 30, 2025 | Jul 1, 2025 | P | 58,780 | $44.00 | Purchase +$2,586,320 | 353,412 | No | Form 4 |
| Biotechnology Value Trading Fund OS LP | Jun 25, 2025 | Jul 1, 2025 | A · derivative | 16,000 | $46.47 | $743,520 | 16,000 | No | Form 4 |
| Baker Bros. Advisors (GP) LLC | Jun 30, 2025 | Jun 30, 2025 | P | 55,191 | $44.00 | Purchase +$2,428,404 | 534,134 | No | Form 4 |
| Baker Bros. Advisors (GP) LLC | Jun 30, 2025 | Jun 30, 2025 | P | 600,309 | $44.00 | Purchase +$26,413,596 | 6,117,295 | No | Form 4 |
| Baker Bros. Advisors (GP) LLC | Jun 30, 2025 | Jun 30, 2025 | P · derivative | 55,191 | $44.00 | Purchase +$2,428,404 | 974,192 | No | Form 4 |
| Baker Bros. Advisors (GP) LLC | Jun 30, 2025 | Jun 30, 2025 | P · derivative | 600,309 | $44.00 | Purchase +$26,413,596 | 10,225,962 | No | Form 4 |
| Ridloff Elena | Jun 25, 2025 | Jun 26, 2025 | A · derivative | 16,000 | $46.47 | $743,520 | 16,000 | No | Form 4 |
| Sandor Victor | Jun 25, 2025 | Jun 26, 2025 | A · derivative | 16,000 | $46.47 | $743,520 | 16,000 | No | Form 4 |
| Booth Bruce | Jun 25, 2025 | Jun 26, 2025 | A · derivative | 16,000 | $46.47 | $743,520 | 16,000 | No | Form 4 |
| Maraganore John | Jun 25, 2025 | Jun 26, 2025 | A · derivative | 16,000 | $46.47 | $743,520 | 16,000 | No | Form 4 |
| Esposito Pamela | Jun 25, 2025 | Jun 26, 2025 | A · derivative | 16,000 | $46.47 | $743,520 | 16,000 | No | Form 4 |
| Hrustanovic Gorjan | Jun 25, 2025 | Jun 26, 2025 | A · derivative | 16,000 | $46.47 | $743,520 | 16,000 | No | Form 4 |
| Albers Jeffrey W. | Jun 25, 2025 | Jun 26, 2025 | A · derivative | 16,000 | $46.47 | $743,520 | 16,000 | No | Form 4 |
| Baker Bros. Advisors LP | Jun 25, 2025 | Jun 26, 2025 | A · derivative | 16,000 | $46.47 | $743,520 | 16,000 | No | Form 4 |
| Baker Bros. Advisors LP | Jun 25, 2025 | Jun 26, 2025 | A · derivative | 16,000 | $46.47 | $743,520 | 16,000 | No | Form 4 |
| Ridloff Elena | Jun 11, 2025 | Jun 11, 2025 | M | 4,500 | $20.29 | $91,305 | 4,500 | Yes | Form 4 |
| Ridloff Elena | Jun 11, 2025 | Jun 11, 2025 | S | 4,500 | $50.00 | Sale −$225,000 | not reported | Yes | Form 4 |
| Ridloff Elena | Jun 11, 2025 | Jun 11, 2025 | M · derivative | 4,500 | $20.29 | $91,305 | 4,500 | Yes | Form 4 |
| Albers Jeffrey W. | Jun 3, 2025 | Jun 3, 2025 | M | 6,349 | $10.34 | $65,649 | 6,349 | Yes | Form 4 |
| Albers Jeffrey W. | Jun 3, 2025 | Jun 3, 2025 | S | 6,349 | $49.00 | Sale −$311,101 | not reported | Yes | Form 4 |
| Albers Jeffrey W. | Jun 3, 2025 | Jun 3, 2025 | M · derivative | 6,349 | $10.34 | $65,649 | 5,000 | Yes | Form 4 |
| Mainolfi NelloChief Executive Officer | Jun 3, 2025 | Jun 3, 2025 | M | 30,000 | $2.08 | $62,400 | 690,482 | Yes | Form 4 |
| Mainolfi NelloChief Executive Officer | Jun 3, 2025 | Jun 3, 2025 | S | 30,000 | $49.00 | Sale −$1,470,000 | 660,482 | Yes | Form 4 |
| Mainolfi NelloChief Executive Officer | Jun 3, 2025 | Jun 3, 2025 | M · derivative | 30,000 | $2.08 | $62,400 | 465,559 | Yes | Form 4 |
| Ridloff Elena | Jun 3, 2025 | Jun 3, 2025 | M | 12,000 | $27.67 | $332,040 | 12,000 | Yes | Form 4 |
| Ridloff Elena | Jun 3, 2025 | Jun 3, 2025 | S | 7,200 | $45.50 | Sale −$327,600 | 4,800 | Yes | Form 4 |
| Ridloff Elena | Jun 3, 2025 | Jun 3, 2025 | S | 4,800 | $47.00 | Sale −$225,600 | not reported | Yes | Form 4 |
| Ridloff Elena | Jun 3, 2025 | Jun 3, 2025 | M · derivative | 12,000 | $27.67 | $332,040 | not reported | Yes | Form 4 |
| Esposito Pamela | Jun 3, 2025 | Jun 3, 2025 | M | 5,000 | $29.55 | $147,750 | 5,000 | Yes | Form 4 |
| Esposito Pamela | Jun 3, 2025 | Jun 3, 2025 | S | 5,000 | $49.04 | Sale −$245,200 | not reported | Yes | Form 4 |
| Esposito Pamela | Jun 3, 2025 | Jun 3, 2025 | M · derivative | 5,000 | $29.55 | $147,750 | 24,127 | Yes | Form 4 |
| Chadwick Jeremy GChief Operating Officer | May 23, 2025 | May 23, 2025 | S | 2,575 | $29.30 | Sale −$75,448 | 66,420 | No | Form 4 |
| Goodman NoahChief Business Officer | Apr 8, 2025 | Apr 9, 2025 | A | 50,000 | $0.00 | $0 | 50,081.44 | No | Form 4 |
| Goodman NoahChief Business Officer | Apr 8, 2025 | Apr 9, 2025 | A · derivative | 100,000 | $21.05 | $2,105,000 | 100,000 | No | Form 4 |
| Jacobs Bruce N.Chief Financial Officer | Mar 31, 2025 | Apr 1, 2025 | M | 25,000 | $2.08 | $52,000 | 226,886 | No | Form 4 |
| Jacobs Bruce N.Chief Financial Officer | Mar 31, 2025 | Apr 1, 2025 | M · derivative | 25,000 | $2.08 | $52,000 | 69,899 | No | Form 4 |
| Gollob JaredChief Medical Officer | Mar 3, 2025 | Mar 3, 2025 | A | 30,000 | $0.00 | $0 | 125,740 | No | Form 4 |
| Gollob JaredChief Medical Officer | Mar 3, 2025 | Mar 3, 2025 | S | 4,695 | $30.33 | Sale −$142,399 | 121,045 | No | Form 4 |
| Gollob JaredChief Medical Officer | Mar 3, 2025 | Mar 3, 2025 | S | 1,045 | $31.00 | Sale −$32,395 | 120,000 | No | Form 4 |
| Gollob JaredChief Medical Officer | Mar 3, 2025 | Mar 3, 2025 | A · derivative | 60,000 | $30.17 | $1,810,200 | 60,000 | No | Form 4 |
| Mainolfi NelloChief Executive Officer | Mar 3, 2025 | Mar 3, 2025 | A · derivative | 365,000 | $30.17 | $11,012,050 | 365,000 | No | Form 4 |
| Jacobs Bruce N.Chief Financial Officer | Mar 3, 2025 | Mar 3, 2025 | A | 30,000 | $0.00 | $0 | 208,921 | No | Form 4 |
| Jacobs Bruce N.Chief Financial Officer | Mar 3, 2025 | Mar 3, 2025 | S | 5,754 | $30.33 | Sale −$174,519 | 203,167 | No | Form 4 |
| Jacobs Bruce N.Chief Financial Officer | Mar 3, 2025 | Mar 3, 2025 | S | 1,281 | $31.00 | Sale −$39,711 | 201,886 | No | Form 4 |
| Jacobs Bruce N.Chief Financial Officer | Mar 3, 2025 | Mar 3, 2025 | A · derivative | 60,000 | $30.17 | $1,810,200 | 60,000 | No | Form 4 |
| Chadwick Jeremy GChief Operating Officer | Mar 3, 2025 | Mar 3, 2025 | A | 25,000 | $0.00 | $0 | 69,183 | No | Form 4 |
| Chadwick Jeremy GChief Operating Officer | Mar 3, 2025 | Mar 3, 2025 | S | 1,131 | $30.33 | Sale −$34,303 | 68,052 | No | Form 4 |
| Chadwick Jeremy GChief Operating Officer | Mar 3, 2025 | Mar 3, 2025 | S | 252 | $31.00 | Sale −$7,812 | 67,800 | No | Form 4 |
| Chadwick Jeremy GChief Operating Officer | Mar 3, 2025 | Mar 3, 2025 | A · derivative | 50,000 | $30.17 | $1,508,500 | 50,000 | No | Form 4 |
| Chiniara EllenChief Legal Officer | Mar 3, 2025 | Mar 3, 2025 | A | 27,500 | $0.00 | $0 | 82,326 | No | Form 4 |
| Chiniara EllenChief Legal Officer | Mar 3, 2025 | Mar 3, 2025 | S | 1,833 | $30.33 | Sale −$55,595 | 80,493 | No | Form 4 |
| Chiniara EllenChief Legal Officer | Mar 3, 2025 | Mar 3, 2025 | S | 408 | $31.00 | Sale −$12,648 | 80,085 | No | Form 4 |
| Chiniara EllenChief Legal Officer | Mar 3, 2025 | Mar 3, 2025 | A · derivative | 55,000 | $30.17 | $1,659,350 | 55,000 | No | Form 4 |
| Jacobs Bruce N.Chief Financial Officer | Jan 10, 2025 | Jan 13, 2025 | M | 10,000 | $2.08 | $20,800 | 178,921 | No | Form 4 |
| Jacobs Bruce N.Chief Financial Officer | Jan 10, 2025 | Jan 13, 2025 | M · derivative | 10,000 | $2.08 | $20,800 | 94,899 | No | Form 4 |
| Mainolfi NelloChief Executive Officer | Jan 10, 2025 | Jan 13, 2025 | M | 10,000 | $2.08 | $20,800 | 659,959 | No | Form 4 |
| Mainolfi NelloChief Executive Officer | Jan 10, 2025 | Jan 13, 2025 | M · derivative | 10,000 | $2.08 | $20,800 | 495,559 | No | Form 4 |
| Chiniara EllenChief Legal Officer | Jan 6, 2025 | Jan 6, 2025 | S | 3,129 | $41.75 | Sale −$130,636 | 54,826 | No | Form 4 |
| Esposito Pamela | Dec 2, 2024 | Dec 2, 2024 | M | 2,500 | $29.55 | $73,875 | 2,500 | Yes | Form 4 |
| Esposito Pamela | Dec 2, 2024 | Dec 2, 2024 | S | 2,500 | $49.00 | Sale −$122,500 | not reported | Yes | Form 4 |
| Esposito Pamela | Dec 2, 2024 | Dec 2, 2024 | M · derivative | 2,500 | $29.55 | $73,875 | 29,127 | Yes | Form 4 |
| Esposito Pamela | Sep 17, 2024 | Sep 17, 2024 | M | 8,500 | $29.55 | $251,175 | 8,500 | Yes | Form 4 |
| Esposito Pamela | Sep 17, 2024 | Sep 17, 2024 | M | 5,000 | $14.18 | $70,900 | 13,500 | Yes | Form 4 |
| Esposito Pamela | Sep 17, 2024 | Sep 17, 2024 | S | 6,350 | $47.75 | Sale −$303,213 | 7,150 | Yes | Form 4 |
| Esposito Pamela | Sep 17, 2024 | Sep 17, 2024 | S | 7,150 | $48.75 | Sale −$348,563 | not reported | Yes | Form 4 |
| Esposito Pamela | Sep 17, 2024 | Sep 17, 2024 | M · derivative | 8,500 | $29.55 | $251,175 | 31,627 | Yes | Form 4 |
| Esposito Pamela | Sep 17, 2024 | Sep 17, 2024 | M · derivative | 5,000 | $14.18 | $70,900 | 7,000 | Yes | Form 4 |
| Albers Jeffrey W. | Aug 26, 2024 | Aug 26, 2024 | M | 5,000 | $10.34 | $51,700 | 5,000 | Yes | Form 4 |
| Albers Jeffrey W. | Aug 26, 2024 | Aug 26, 2024 | S | 5,000 | $49.10 | Sale −$245,500 | not reported | Yes | Form 4 |
| Albers Jeffrey W. | Aug 26, 2024 | Aug 26, 2024 | M · derivative | 5,000 | $10.34 | $51,700 | 11,349 | Yes | Form 4 |
| 667, L.P. | Aug 21, 2024 | Aug 22, 2024 | P · derivative | 347,572 | $40.75 | Purchase +$14,163,559 | 919,001 | No | Form 4 |
| 667, L.P. | Aug 21, 2024 | Aug 22, 2024 | P · derivative | 2,246,587 | $40.75 | Purchase +$91,548,420 | 9,625,653 | No | Form 4 |
| Biotechnology Value Fund II LP | Aug 20, 2024 | Aug 22, 2024 | P · derivative | 201,546 | $40.75 | Purchase +$8,213,000 | 201,546 | No | Form 4 |
| Biotechnology Value Fund II LP | Aug 20, 2024 | Aug 22, 2024 | P · derivative | 156,742 | $40.75 | Purchase +$6,387,237 | 156,742 | No | Form 4 |
| 667, L.P. | Aug 20, 2024 | Aug 22, 2024 | P | 1 | $46.41 | Purchase +$46 | 5,516,986 | No | Form 4 |
| Gollob JaredChief Medical Officer | Jul 16, 2024 | Jul 16, 2024 | M | 23,145 | $2.08 | $48,142 | 118,885 | Yes | Form 4 |
| Gollob JaredChief Medical Officer | Jul 16, 2024 | Jul 16, 2024 | S | 13,281 | $45.59 | Sale −$605,481 | 105,604 | Yes | Form 4 |
| Gollob JaredChief Medical Officer | Jul 16, 2024 | Jul 16, 2024 | S | 9,864 | $46.10 | Sale −$454,730 | 95,470 | Yes | Form 4 |
| Gollob JaredChief Medical Officer | Jul 16, 2024 | Jul 16, 2024 | M · derivative | 23,145 | $2.08 | $48,142 | 22,883 | Yes | Form 4 |
| Gollob JaredChief Medical Officer | Jul 15, 2024 | Jul 16, 2024 | M | 16,455 | $2.08 | $34,226 | 112,195 | Yes | Form 4 |
| Gollob JaredChief Medical Officer | Jul 15, 2024 | Jul 16, 2024 | S | 16,455 | $45.15 | Sale −$742,943 | 95,740 | Yes | Form 4 |
| Gollob JaredChief Medical Officer | Jul 15, 2024 | Jul 16, 2024 | M · derivative | 16,455 | $2.08 | $34,226 | 46,028 | Yes | Form 4 |
| Booth Bruce | Jul 9, 2024 | Jul 9, 2024 | S | 24,449 | $35.57 | Sale −$869,651 | 4,523,951 | Yes | Form 4 |
| Booth Bruce | Jul 9, 2024 | Jul 9, 2024 | S | 28,718 | $36.40 | Sale −$1,045,335 | 4,495,233 | Yes | Form 4 |
| Booth Bruce | Jul 9, 2024 | Jul 9, 2024 | S | 41,763 | $37.41 | Sale −$1,562,354 | 4,453,470 | Yes | Form 4 |
| Booth Bruce | Jul 9, 2024 | Jul 9, 2024 | S | 183,868 | $38.48 | Sale −$7,075,241 | 4,269,602 | Yes | Form 4 |
| Booth Bruce | Jul 9, 2024 | Jul 9, 2024 | S | 96,386 | $39.26 | Sale −$3,784,114 | 4,173,216 | Yes | Form 4 |
| Booth Bruce | Jul 9, 2024 | Jul 9, 2024 | S | 5,133 | $35.57 | Sale −$182,581 | 796,889 | Yes | Form 4 |
| Booth Bruce | Jul 9, 2024 | Jul 9, 2024 | S | 6,030 | $36.40 | Sale −$219,492 | 790,859 | Yes | Form 4 |
| Booth Bruce | Jul 9, 2024 | Jul 9, 2024 | S | 8,769 | $37.41 | Sale −$328,048 | 782,090 | Yes | Form 4 |