MAZEMaze Therapeutics, Inc.
- Market cap
- $1.72B
- as of 2026-10-23
- Latest close
- $31.01
- as of 2026-10-23
- Sector
- Healthcare
- as of 2026-10-24
- Industry
- Biotechnology
- as of 2026-10-24
Cluster
No cluster in the last 90 days under the default rule (14d · ≥2 insiders · all roles).
Form 4 historysince 2025-02-04
| Insider | Traded | Filed | Type | Shares | Price | Value | Owned after | 10b5-1 plan | Filing |
|---|---|---|---|---|---|---|---|---|---|
| Bernstein HaroldPresident, R&D & CMO | Oct 1 | Oct 2 | M | 16,141 | $10.42 | $168,189 | 16,141 | Yes | Form 4 |
| Bernstein HaroldPresident, R&D & CMO | Oct 1 | Oct 2 | S | 16,141 | $26.93 | Sale −$434,743 | not reported | Yes | Form 4 |
| Bernstein HaroldPresident, R&D & CMO | Oct 1 | Oct 2 | M · derivative | 16,141 | $10.42 | $168,189 | 144,521 | Yes | Form 4 |
| Coloma Jason VChief Executive Officer | Oct 1 | Oct 2 | S | 2,593 | $27.02 | Sale −$70,073 | 15,558 | Yes | Form 4 |
| Coloma Jason VChief Executive Officer | Oct 1 | Oct 2 | S | 31,908 | $27.02 | Sale −$862,186 | 191,447 | Yes | Form 4 |
| Dandekar AtulCSBO | Sep 29 | Oct 1 | M | 7,500 | $10.42 | $78,150 | 39,816 | Yes | Form 4 |
| Dandekar AtulCSBO | Sep 29 | Oct 1 | S | 7,500 | $27.06 | Sale −$202,921 | 32,316 | Yes | Form 4 |
| Dandekar AtulCSBO | Sep 29 | Oct 1 | M · derivative | 7,500 | $10.42 | $78,150 | 6,643 | Yes | Form 4 |
| Bernstein HaroldPresident, R&D & CMO | Sep 4 | Sep 8 | S | 9,705 | $26.22 | Sale −$254,465 | not reported | Yes | Form 4 |
| Coloma Jason VChief Executive Officer | Sep 3 | Sep 4 | S | 11,282 | $26.01 | Sale −$293,445 | 27,491 | No | Form 4 |
| Coloma Jason VChief Executive Officer | Sep 3 | Sep 4 | S | 129 | $25.77 | Sale −$3,324 | 27,362 | No | Form 4 |
| Courtney PhillipsGC and Corp. Secretary | Sep 3 | Sep 4 | S | 1,990 | $26.01 | Sale −$51,760 | 7,029 | No | Form 4 |
| Courtney PhillipsGC and Corp. Secretary | Sep 3 | Sep 4 | S | 22 | $25.78 | Sale −$567 | 7,007 | No | Form 4 |
| Dandekar AtulCSBO | Sep 3 | Sep 4 | S | 3,207 | $26.01 | Sale −$83,414 | 32,352 | No | Form 4 |
| Dandekar AtulCSBO | Sep 3 | Sep 4 | S | 36 | $25.81 | Sale −$929 | 32,316 | No | Form 4 |
| Bernstein HaroldPresident, R&D & CMO | Sep 3 | Sep 4 | S | 5,130 | $26.01 | Sale −$133,431 | 9,764 | No | Form 4 |
| Bernstein HaroldPresident, R&D & CMO | Sep 3 | Sep 4 | S | 59 | $25.78 | Sale −$1,521 | 9,705 | No | Form 4 |
| Coloma Jason VChief Executive Officer | Sep 2 | Sep 4 | S | 9,852 | $26.38 | Sale −$259,896 | 40,148 | No | Form 4 |
| Coloma Jason VChief Executive Officer | Sep 2 | Sep 4 | S | 1,375 | $27.12 | Sale −$37,290 | 38,773 | No | Form 4 |
| Courtney PhillipsGC and Corp. Secretary | Sep 2 | Sep 4 | S | 1,738 | $26.38 | Sale −$45,848 | 9,262 | No | Form 4 |
| Courtney PhillipsGC and Corp. Secretary | Sep 2 | Sep 4 | S | 243 | $27.12 | Sale −$6,590 | 9,019 | No | Form 4 |
| Dandekar AtulCSBO | Sep 2 | Sep 4 | S | 2,800 | $26.38 | Sale −$73,864 | 35,950 | No | Form 4 |
| Dandekar AtulCSBO | Sep 2 | Sep 4 | S | 391 | $27.12 | Sale −$10,604 | 35,559 | No | Form 4 |
| Bernstein HaroldPresident, R&D & CMO | Sep 2 | Sep 4 | S | 4,481 | $26.38 | Sale −$118,209 | 15,519 | No | Form 4 |
| Bernstein HaroldPresident, R&D & CMO | Sep 2 | Sep 4 | S | 625 | $27.12 | Sale −$16,950 | 14,894 | No | Form 4 |
| Coloma Jason VChief Executive Officer | Sep 1 | Sep 3 | S | 2,593 | $26.31 | Sale −$68,222 | 18,151 | Yes | Form 4 |
| Coloma Jason VChief Executive Officer | Sep 1 | Sep 3 | S | 31,908 | $26.29 | Sale −$838,861 | 223,355 | Yes | Form 4 |
| Coloma Jason VChief Executive Officer | Sep 1 | Sep 3 | M | 50,000 | $0.00 | $0 | 50,000 | Yes | Form 4 |
| Coloma Jason VChief Executive Officer | Sep 1 | Sep 3 | M · derivative | 50,000 | $0.00 | $0 | 50,000 | Yes | Form 4 |
| Courtney PhillipsGC and Corp. Secretary | Sep 1 | Sep 3 | M | 11,000 | $0.00 | $0 | 11,000 | No | Form 4 |
| Courtney PhillipsGC and Corp. Secretary | Sep 1 | Sep 3 | M · derivative | 11,000 | $0.00 | $0 | 11,000 | No | Form 4 |
| Dandekar AtulCSBO | Sep 1 | Sep 3 | M | 12,500 | $0.00 | $0 | 38,750 | No | Form 4 |
| Dandekar AtulCSBO | Sep 1 | Sep 3 | M · derivative | 12,500 | $0.00 | $0 | 12,500 | No | Form 4 |
| Bernstein HaroldPresident, R&D & CMO | Sep 1 | Sep 3 | M | 16,141 | $10.42 | $168,189 | 16,141 | Yes | Form 4 |
| Bernstein HaroldPresident, R&D & CMO | Sep 1 | Sep 3 | S | 16,141 | $26.36 | Sale −$425,477 | not reported | Yes | Form 4 |
| Bernstein HaroldPresident, R&D & CMO | Sep 1 | Sep 3 | M | 20,000 | $0.00 | $0 | 20,000 | Yes | Form 4 |
| Bernstein HaroldPresident, R&D & CMO | Sep 1 | Sep 3 | M · derivative | 16,141 | $10.42 | $168,189 | 160,662 | Yes | Form 4 |
| Bernstein HaroldPresident, R&D & CMO | Sep 1 | Sep 3 | M · derivative | 20,000 | $0.00 | $0 | 20,000 | Yes | Form 4 |
| Dandekar AtulCSBO | Aug 28 | Aug 31 | M | 7,500 | $10.42 | $78,150 | 33,750 | Yes | Form 4 |
| Dandekar AtulCSBO | Aug 28 | Aug 31 | S | 7,500 | $27.58 | Sale −$206,850 | 26,250 | Yes | Form 4 |
| Dandekar AtulCSBO | Aug 28 | Aug 31 | M · derivative | 7,500 | $10.42 | $78,150 | 14,143 | Yes | Form 4 |
| Johnson Paula A | Aug 13 | Aug 17 | A · derivative | 36,000 | $27.67 | $996,120 | 36,000 | No | Form 4 |
| Kornowski Sophie | Aug 13 | Aug 17 | A · derivative | 36,000 | $27.67 | $996,120 | 36,000 | No | Form 4 |
| Bernstein HaroldPresident, R&D & CMO | Aug 13 | Aug 14 | M | 16,142 | $10.42 | $168,200 | 16,142 | Yes | Form 4 |
| Bernstein HaroldPresident, R&D & CMO | Aug 13 | Aug 14 | S | 16,142 | $27.61 | Sale −$445,681 | not reported | Yes | Form 4 |
| Bernstein HaroldPresident, R&D & CMO | Aug 13 | Aug 14 | M · derivative | 16,142 | $10.42 | $168,200 | 176,803 | Yes | Form 4 |
| Coloma Jason VChief Executive Officer | Aug 3 | Aug 5 | S | 2,439 | $26.71 | Sale −$65,146 | 20,898 | Yes | Form 4 |
| Coloma Jason VChief Executive Officer | Aug 3 | Aug 5 | S | 154 | $27.09 | Sale −$4,172 | 20,744 | Yes | Form 4 |
| Coloma Jason VChief Executive Officer | Aug 3 | Aug 5 | S | 30,304 | $26.71 | Sale −$809,420 | 256,867 | Yes | Form 4 |
| Coloma Jason VChief Executive Officer | Aug 3 | Aug 5 | S | 1,604 | $27.09 | Sale −$43,452 | 255,263 | Yes | Form 4 |
| Dandekar AtulCSBO | Jul 29 | Jul 31 | M | 7,500 | $10.42 | $78,150 | 33,750 | Yes | Form 4 |
| Dandekar AtulCSBO | Jul 29 | Jul 31 | S | 7,100 | $27.31 | Sale −$193,901 | 26,650 | Yes | Form 4 |
| Dandekar AtulCSBO | Jul 29 | Jul 31 | S | 400 | $27.89 | Sale −$11,156 | 26,250 | Yes | Form 4 |
| Dandekar AtulCSBO | Jul 29 | Jul 31 | M · derivative | 7,500 | $10.42 | $78,150 | 21,643 | Yes | Form 4 |
| Coloma Jason VChief Executive Officer | Jul 1 | Jul 2 | S | 2,593 | $29.98 | Sale −$77,738 | 23,337 | Yes | Form 4 |
| Coloma Jason VChief Executive Officer | Jul 1 | Jul 2 | S | 30,311 | $29.95 | Sale −$907,814 | 288,768 | Yes | Form 4 |
| Coloma Jason VChief Executive Officer | Jul 1 | Jul 2 | S | 1,597 | $30.44 | Sale −$48,613 | 287,171 | Yes | Form 4 |
| Bernstein HaroldPresident, R&D & CMO | Jul 1 | Jul 2 | M | 14,609 | $10.42 | $152,226 | 14,609 | Yes | Form 4 |
| Bernstein HaroldPresident, R&D & CMO | Jul 1 | Jul 2 | S | 13,409 | $29.87 | Sale −$400,527 | 1,200 | Yes | Form 4 |
| Bernstein HaroldPresident, R&D & CMO | Jul 1 | Jul 2 | S | 1,200 | $30.34 | Sale −$36,408 | not reported | Yes | Form 4 |
| Bernstein HaroldPresident, R&D & CMO | Jul 1 | Jul 2 | M · derivative | 14,609 | $10.42 | $152,226 | 192,945 | Yes | Form 4 |
| Dandekar AtulCSBO | Jun 29 | Jul 1 | M | 7,500 | $10.42 | $78,150 | 33,750 | Yes | Form 4 |
| Dandekar AtulCSBO | Jun 29 | Jul 1 | S | 7,500 | $28.02 | Sale −$210,150 | 26,250 | Yes | Form 4 |
| Dandekar AtulCSBO | Jun 29 | Jul 1 | M · derivative | 7,500 | $10.42 | $78,150 | 29,143 | Yes | Form 4 |
| Coloma Jason VChief Executive Officer | Jun 23 | Jun 24 | S | 23,865 | $26.05 | Sale −$621,683 | 319,079 | Yes | Form 4 |
| Coloma Jason VChief Executive Officer | Jun 22 | Jun 24 | S | 1,953 | $26.00 | Sale −$50,778 | 342,944 | Yes | Form 4 |
| Coloma Jason VChief Executive Officer | Jun 22 | Jun 24 | S | 2,040 | $26.00 | Sale −$53,040 | 25,930 | Yes | Form 4 |
| Homcy Charles J | Jun 8 | Jun 10 | A · derivative | 18,000 | $23.58 | $424,440 | 18,000 | No | Form 4 |
| Scheller Richard H | Jun 8 | Jun 10 | A · derivative | 18,000 | $23.58 | $424,440 | 18,000 | No | Form 4 |
| Spiegelman Daniel K | Jun 8 | Jun 10 | A · derivative | 18,000 | $23.58 | $424,440 | 18,000 | No | Form 4 |
| Lim Jonathan E | Jun 8 | Jun 10 | A · derivative | 18,000 | $23.58 | $424,440 | 18,000 | No | Form 4 |
| Hoppenot Herve | Jun 8 | Jun 10 | A · derivative | 18,000 | $23.58 | $424,440 | 18,000 | No | Form 4 |
| Andrews Nancy C | Jun 8 | Jun 10 | A · derivative | 18,000 | $23.58 | $424,440 | 18,000 | No | Form 4 |
| Coloma Jason VChief Executive Officer | Jun 1 | Jun 3 | S | 6,090 | $26.20 | Sale −$159,558 | 344,897 | Yes | Form 4 |
| Coloma Jason VChief Executive Officer | Jun 1 | Jun 3 | S | 553 | $26.24 | Sale −$14,511 | 27,970 | Yes | Form 4 |
| Bernstein HaroldPresident, R&D & CMO | Jun 1 | Jun 3 | M | 14,853 | $10.42 | $154,768 | 14,853 | Yes | Form 4 |
| Bernstein HaroldPresident, R&D & CMO | Jun 1 | Jun 3 | S | 13,253 | $25.57 | Sale −$338,879 | 1,600 | Yes | Form 4 |
| Bernstein HaroldPresident, R&D & CMO | Jun 1 | Jun 3 | S | 1,600 | $26.36 | Sale −$42,176 | not reported | Yes | Form 4 |
| Bernstein HaroldPresident, R&D & CMO | Jun 1 | Jun 3 | M · derivative | 14,853 | $10.42 | $154,768 | 207,554 | Yes | Form 4 |
| Dandekar AtulCSBO | May 29 | Jun 2 | M | 7,500 | $10.42 | $78,150 | 32,308 | Yes | Form 4 |
| Dandekar AtulCSBO | May 29 | Jun 2 | S | 7,500 | $26.34 | Sale −$197,550 | 24,808 | Yes | Form 4 |
| Dandekar AtulCSBO | May 29 | Jun 2 | M · derivative | 7,500 | $10.42 | $78,150 | 36,643 | Yes | Form 4 |
| Coloma Jason VChief Executive Officer | May 26 | May 27 | S | 25,582 | $26.02 | Sale −$665,644 | 350,987 | Yes | Form 4 |
| Coloma Jason VChief Executive Officer | May 22 | May 27 | S | 4,504 | $26.00 | Sale −$117,104 | 376,569 | Yes | Form 4 |
| Coloma Jason VChief Executive Officer | May 22 | May 27 | S | 2,478 | $26.00 | Sale −$64,428 | 28,523 | Yes | Form 4 |
| Coloma Jason VChief Executive Officer | May 15 | May 18 | S | 1,822 | $26.00 | Sale −$47,372 | 381,073 | Yes | Form 4 |
| Coloma Jason VChief Executive Officer | May 15 | May 18 | S | 116 | $26.00 | Sale −$3,016 | 31,001 | Yes | Form 4 |
| Bernstein HaroldPresident, R&D & CMO | May 14 | May 18 | M | 15,000 | $10.42 | $156,300 | 15,000 | Yes | Form 4 |
| Bernstein HaroldPresident, R&D & CMO | May 14 | May 18 | S | 15,000 | $26.22 | Sale −$393,300 | not reported | Yes | Form 4 |
| Bernstein HaroldPresident, R&D & CMO | May 14 | May 18 | M · derivative | 15,000 | $10.42 | $156,300 | 222,407 | Yes | Form 4 |
| Homcy Charles J | May 4 | May 6 | G | 7,422 | $0.00 | $0 | 31,113 | No | Form 4 |
| Dandekar AtulCSBO | May 4 | May 6 | M | 8,320 | $10.42 | $86,694 | 18,823 | No | Form 4 |
| Dandekar AtulCSBO | May 4 | May 6 | M | 5,985 | $10.42 | $62,364 | 24,808 | No | Form 4 |
| Dandekar AtulCSBO | May 4 | May 6 | M · derivative | 8,320 | $10.42 | $86,694 | 20,204 | No | Form 4 |
| Dandekar AtulCSBO | May 4 | May 6 | M · derivative | 5,985 | $10.42 | $62,364 | 27,725 | No | Form 4 |
| Dandekar AtulCSBO | Apr 29 | May 1 | M | 7,500 | $10.42 | $78,150 | 18,003 | Yes | Form 4 |
| Dandekar AtulCSBO | Apr 29 | May 1 | S | 7,500 | $25.37 | Sale −$190,275 | 10,503 | Yes | Form 4 |
| Dandekar AtulCSBO | Apr 29 | May 1 | M · derivative | 7,500 | $10.42 | $78,150 | 44,143 | Yes | Form 4 |
| Bernstein HaroldPresident, R&D & CMO | Apr 1 | Apr 2 | M | 15,000 | $10.42 | $156,300 | 15,000 | Yes | Form 4 |
| Bernstein HaroldPresident, R&D & CMO | Apr 1 | Apr 2 | S | 11,352 | $29.24 | Sale −$331,932 | 3,648 | Yes | Form 4 |
| Bernstein HaroldPresident, R&D & CMO | Apr 1 | Apr 2 | S | 3,348 | $30.06 | Sale −$100,641 | 300 | Yes | Form 4 |
| Bernstein HaroldPresident, R&D & CMO | Apr 1 | Apr 2 | S | 300 | $31.07 | Sale −$9,321 | not reported | Yes | Form 4 |
| Bernstein HaroldPresident, R&D & CMO | Apr 1 | Apr 2 | M · derivative | 15,000 | $10.42 | $156,300 | 237,407 | Yes | Form 4 |
| Bachrodt AmySVP, Finance | Apr 1 | Apr 2 | M | 2,500 | $10.42 | $26,050 | 15,465 | Yes | Form 4 |
| Bachrodt AmySVP, Finance | Apr 1 | Apr 2 | S | 2,200 | $29.32 | Sale −$64,504 | 13,265 | Yes | Form 4 |
| Bachrodt AmySVP, Finance | Apr 1 | Apr 2 | S | 300 | $30.34 | Sale −$9,102 | 12,965 | Yes | Form 4 |
| Bachrodt AmySVP, Finance | Apr 1 | Apr 2 | M · derivative | 2,500 | $10.42 | $26,050 | 33,833 | Yes | Form 4 |
| Dandekar AtulCSBO | Mar 30 | Apr 1 | M | 7,500 | $10.42 | $78,150 | 18,003 | Yes | Form 4 |
| Dandekar AtulCSBO | Mar 30 | Apr 1 | S | 6,710 | $29.26 | Sale −$196,335 | 11,293 | Yes | Form 4 |
| Dandekar AtulCSBO | Mar 30 | Apr 1 | S | 790 | $30.02 | Sale −$23,716 | 10,503 | Yes | Form 4 |
| Dandekar AtulCSBO | Mar 30 | Apr 1 | M · derivative | 7,500 | $10.42 | $78,150 | 51,643 | Yes | Form 4 |
| Kumar Neil | Mar 27 | Mar 31 | A · derivative | 33,417 | $30.38 | $1,015,208 | 33,417 | No | Form 4 |
| Bernstein HaroldPresident, R&D & CMO | Mar 20 | Mar 20 | M | 15,000 | $10.42 | $156,300 | 15,000 | Yes | Form 4 |
| Bernstein HaroldPresident, R&D & CMO | Mar 20 | Mar 20 | S | 6,161 | $48.20 | Sale −$296,960 | 8,839 | Yes | Form 4 |
| Bernstein HaroldPresident, R&D & CMO | Mar 20 | Mar 20 | S | 3,795 | $49.32 | Sale −$187,169 | 5,044 | Yes | Form 4 |
| Bernstein HaroldPresident, R&D & CMO | Mar 20 | Mar 20 | S | 5,044 | $50.02 | Sale −$252,301 | not reported | Yes | Form 4 |
| Bernstein HaroldPresident, R&D & CMO | Mar 20 | Mar 20 | M · derivative | 15,000 | $10.42 | $156,300 | 252,407 | Yes | Form 4 |
| Bernstein HaroldPresident, R&D & CMO | Mar 10 | Mar 12 | M | 30,000 | $10.42 | $312,600 | 30,000 | Yes | Form 4 |
| Bernstein HaroldPresident, R&D & CMO | Mar 10 | Mar 12 | S | 29,652 | $50.45 | Sale −$1,495,943 | 348 | Yes | Form 4 |
| Bernstein HaroldPresident, R&D & CMO | Mar 10 | Mar 12 | S | 348 | $51.02 | Sale −$17,755 | not reported | Yes | Form 4 |
| Bernstein HaroldPresident, R&D & CMO | Mar 10 | Mar 12 | M · derivative | 30,000 | $10.42 | $312,600 | 267,407 | Yes | Form 4 |
| Coloma Jason VChief Executive Officer | Mar 2 | Mar 3 | A · derivative | 150,000 | $45.61 | $6,841,500 | 150,000 | No | Form 4 |
| Coloma Jason VChief Executive Officer | Mar 2 | Mar 3 | A · derivative | 75,000 | $0.00 | $0 | 75,000 | No | Form 4 |
| Courtney PhillipsGC and Corp. Secretary | Mar 2 | Mar 3 | A · derivative | 32,000 | $45.61 | $1,459,520 | 32,000 | No | Form 4 |
| Courtney PhillipsGC and Corp. Secretary | Mar 2 | Mar 3 | A · derivative | 16,000 | $0.00 | $0 | 16,000 | No | Form 4 |
| Tahir MisbahChief Financial Officer | Mar 2 | Mar 3 | A · derivative | 40,000 | $45.61 | $1,824,400 | 40,000 | No | Form 4 |
| Tahir MisbahChief Financial Officer | Mar 2 | Mar 3 | A · derivative | 20,000 | $0.00 | $0 | 20,000 | No | Form 4 |
| Dandekar AtulCSBO | Mar 2 | Mar 3 | A · derivative | 38,000 | $45.61 | $1,733,180 | 38,000 | Yes | Form 4 |
| Dandekar AtulCSBO | Mar 2 | Mar 3 | A · derivative | 19,000 | $0.00 | $0 | 19,000 | Yes | Form 4 |
| Bernstein HaroldPresident, R&D & CMO | Mar 2 | Mar 3 | A · derivative | 48,000 | $45.61 | $2,189,280 | 48,000 | No | Form 4 |
| Bernstein HaroldPresident, R&D & CMO | Mar 2 | Mar 3 | A · derivative | 24,000 | $0.00 | $0 | 24,000 | No | Form 4 |
| Bachrodt AmySVP, Finance | Mar 2 | Mar 3 | M | 5,000 | $10.42 | $52,100 | 17,965 | Yes | Form 4 |
| Bachrodt AmySVP, Finance | Mar 2 | Mar 3 | S | 1,300 | $44.44 | Sale −$57,772 | 16,665 | Yes | Form 4 |
| Bachrodt AmySVP, Finance | Mar 2 | Mar 3 | S | 3,700 | $45.47 | Sale −$168,239 | 12,965 | Yes | Form 4 |
| Bachrodt AmySVP, Finance | Mar 2 | Mar 3 | M · derivative | 5,000 | $10.42 | $52,100 | 36,333 | Yes | Form 4 |
| Bachrodt AmySVP, Finance | Mar 2 | Mar 3 | A · derivative | 32,000 | $45.61 | $1,459,520 | 32,000 | Yes | Form 4 |
| Bachrodt AmySVP, Finance | Mar 2 | Mar 3 | A · derivative | 16,000 | $0.00 | $0 | 16,000 | Yes | Form 4 |
| Dandekar AtulCSBO | Feb 27 | Mar 3 | M | 7,500 | $10.42 | $78,150 | 18,003 | Yes | Form 4 |
| Dandekar AtulCSBO | Feb 27 | Mar 3 | S | 3,739 | $45.13 | Sale −$168,741 | 14,264 | Yes | Form 4 |
| Dandekar AtulCSBO | Feb 27 | Mar 3 | S | 3,761 | $45.72 | Sale −$171,953 | 10,503 | Yes | Form 4 |
| Dandekar AtulCSBO | Feb 27 | Mar 3 | M · derivative | 7,500 | $10.42 | $78,150 | 59,143 | Yes | Form 4 |
| Bernstein HaroldPresident, R&D & CMO | Feb 2 | Feb 4 | M | 15,000 | $10.42 | $156,300 | 15,000 | Yes | Form 4 |
| Bernstein HaroldPresident, R&D & CMO | Feb 2 | Feb 4 | S | 600 | $44.21 | Sale −$26,526 | 14,400 | Yes | Form 4 |
| Bernstein HaroldPresident, R&D & CMO | Feb 2 | Feb 4 | S | 8,364 | $45.89 | Sale −$383,824 | 6,036 | Yes | Form 4 |
| Bernstein HaroldPresident, R&D & CMO | Feb 2 | Feb 4 | S | 5,936 | $46.37 | Sale −$275,252 | 100 | Yes | Form 4 |
| Bernstein HaroldPresident, R&D & CMO | Feb 2 | Feb 4 | S | 100 | $47.23 | Sale −$4,723 | not reported | Yes | Form 4 |
| Bernstein HaroldPresident, R&D & CMO | Feb 2 | Feb 4 | M · derivative | 15,000 | $10.42 | $156,300 | 297,407 | Yes | Form 4 |
| Bachrodt AmySVP, Finance | Feb 2 | Feb 4 | M | 4,844 | $10.42 | $50,474 | 17,809 | Yes | Form 4 |
| Bachrodt AmySVP, Finance | Feb 2 | Feb 4 | M | 156 | $10.42 | $1,626 | 17,965 | Yes | Form 4 |
| Bachrodt AmySVP, Finance | Feb 2 | Feb 4 | S | 200 | $44.15 | Sale −$8,830 | 17,765 | Yes | Form 4 |
| Bachrodt AmySVP, Finance | Feb 2 | Feb 4 | S | 4,064 | $46.03 | Sale −$187,066 | 13,701 | Yes | Form 4 |
| Bachrodt AmySVP, Finance | Feb 2 | Feb 4 | S | 736 | $46.63 | Sale −$34,320 | 12,965 | Yes | Form 4 |
| Bachrodt AmySVP, Finance | Feb 2 | Feb 4 | M · derivative | 4,844 | $10.42 | $50,474 | 3,025 | Yes | Form 4 |
| Bachrodt AmySVP, Finance | Feb 2 | Feb 4 | M · derivative | 156 | $10.42 | $1,626 | 41,333 | Yes | Form 4 |
| Dandekar AtulCSBO | Jan 29 | Feb 2 | M | 7,500 | $10.42 | $78,150 | 18,003 | Yes | Form 4 |
| Dandekar AtulCSBO | Jan 29 | Feb 2 | S | 1,200 | $43.18 | Sale −$51,816 | 16,803 | Yes | Form 4 |
| Dandekar AtulCSBO | Jan 29 | Feb 2 | S | 3,500 | $44.04 | Sale −$154,140 | 13,303 | Yes | Form 4 |
| Dandekar AtulCSBO | Jan 29 | Feb 2 | S | 2,800 | $45.01 | Sale −$126,028 | 10,503 | Yes | Form 4 |
| Dandekar AtulCSBO | Jan 29 | Feb 2 | M · derivative | 7,500 | $10.42 | $78,150 | 66,643 | Yes | Form 4 |
| Bachrodt AmySVP, Finance | Jan 22 | Jan 26 | M | 2,497 | $10.42 | $26,019 | 15,462 | Yes | Form 4 |
| Bachrodt AmySVP, Finance | Jan 22 | Jan 26 | M | 2,503 | $10.42 | $26,081 | 17,965 | Yes | Form 4 |
| Bachrodt AmySVP, Finance | Jan 22 | Jan 26 | S | 5,000 | $45.52 | Sale −$227,600 | 12,965 | Yes | Form 4 |
| Bachrodt AmySVP, Finance | Jan 22 | Jan 26 | M · derivative | 2,497 | $10.42 | $26,019 | 486 | Yes | Form 4 |
| Bachrodt AmySVP, Finance | Jan 22 | Jan 26 | M · derivative | 2,503 | $10.42 | $26,081 | 7,869 | Yes | Form 4 |
| Bernstein HaroldPresident, R&D & CMO | Jan 7 | Jan 9 | M | 25,156 | $10.42 | $262,126 | 25,156 | Yes | Form 4 |
| Bernstein HaroldPresident, R&D & CMO | Jan 7 | Jan 9 | S | 25,156 | $40.20 | Sale −$1,011,271 | not reported | Yes | Form 4 |
| Bernstein HaroldPresident, R&D & CMO | Jan 7 | Jan 9 | M · derivative | 25,156 | $10.42 | $262,126 | 312,407 | Yes | Form 4 |
| Sohn Catherine A. | Jan 7 | Jan 8 | M | 20,744 | $10.42 | $216,152 | 20,744 | No | Form 4 |
| Sohn Catherine A. | Jan 7 | Jan 8 | M | 2,895 | $10.42 | $30,166 | 23,639 | No | Form 4 |
| Sohn Catherine A. | Jan 7 | Jan 8 | M | 3,281 | $10.42 | $34,188 | 26,920 | No | Form 4 |
| Sohn Catherine A. | Jan 7 | Jan 8 | S | 26,920 | $39.11 | Sale −$1,052,841 | not reported | No | Form 4 |
| Sohn Catherine A. | Jan 7 | Jan 8 | M · derivative | 20,744 | $10.42 | $216,152 | not reported | No | Form 4 |
| Sohn Catherine A. | Jan 7 | Jan 8 | M · derivative | 2,895 | $10.42 | $30,166 | 316 | No | Form 4 |
| Sohn Catherine A. | Jan 7 | Jan 8 | M · derivative | 3,281 | $10.42 | $34,188 | 5,805 | No | Form 4 |
| Sohn Catherine A. | Jan 6 | Jan 8 | M | 2,493 | $10.42 | $25,977 | 2,493 | No | Form 4 |
| Sohn Catherine A. | Jan 6 | Jan 8 | S | 2,493 | $38.62 | Sale −$96,280 | not reported | No | Form 4 |
| Sohn Catherine A. | Jan 6 | Jan 8 | M · derivative | 2,493 | $10.42 | $25,977 | 3,211 | No | Form 4 |
| Bernstein HaroldPresident, R&D & CMO | Jan 5 | Jan 6 | M | 412 | $10.42 | $4,293 | 412 | Yes | Form 4 |
| Bernstein HaroldPresident, R&D & CMO | Jan 5 | Jan 6 | S | 412 | $40.00 | Sale −$16,480 | not reported | Yes | Form 4 |
| Bernstein HaroldPresident, R&D & CMO | Jan 5 | Jan 6 | M · derivative | 412 | $10.42 | $4,293 | 337,563 | Yes | Form 4 |
| Bernstein HaroldPresident, R&D & CMO | Jan 2 | Jan 6 | M | 4,432 | $10.42 | $46,181 | 4,432 | Yes | Form 4 |
| Bernstein HaroldPresident, R&D & CMO | Jan 2 | Jan 6 | S | 4,432 | $40.43 | Sale −$179,186 | not reported | Yes | Form 4 |
| Bernstein HaroldPresident, R&D & CMO | Jan 2 | Jan 6 | M · derivative | 4,432 | $10.42 | $46,181 | 337,975 | Yes | Form 4 |
| Bachrodt AmySVP, Finance | Jan 2 | Jan 6 | M | 204 | $10.42 | $2,126 | 13,169 | Yes | Form 4 |
| Bachrodt AmySVP, Finance | Jan 2 | Jan 6 | M | 4,796 | $10.42 | $49,974 | 17,965 | Yes | Form 4 |
| Bachrodt AmySVP, Finance | Jan 2 | Jan 6 | S | 2,405 | $38.70 | Sale −$93,074 | 15,560 | Yes | Form 4 |
| Bachrodt AmySVP, Finance | Jan 2 | Jan 6 | S | 2,595 | $39.57 | Sale −$102,684 | 12,965 | Yes | Form 4 |
| Bachrodt AmySVP, Finance | Jan 2 | Jan 6 | M · derivative | 204 | $10.42 | $2,126 | 2,377 | Yes | Form 4 |
| Bachrodt AmySVP, Finance | Jan 2 | Jan 6 | M · derivative | 4,796 | $10.42 | $49,974 | 2,983 | Yes | Form 4 |
| Dandekar AtulCSBO | Dec 30, 2025 | Dec 31, 2025 | M | 100 | $10.42 | $1,042 | 10,603 | Yes | Form 4 |
| Dandekar AtulCSBO | Dec 30, 2025 | Dec 31, 2025 | S | 100 | $40.36 | Sale −$4,036 | 10,503 | Yes | Form 4 |
| Dandekar AtulCSBO | Dec 30, 2025 | Dec 31, 2025 | M · derivative | 100 | $10.42 | $1,042 | 74,143 | Yes | Form 4 |
| Bachrodt AmySVP, Finance | Dec 30, 2025 | Dec 31, 2025 | M | 2,395 | $10.42 | $24,956 | 15,360 | Yes | Form 4 |
| Bachrodt AmySVP, Finance | Dec 30, 2025 | Dec 31, 2025 | M | 2,605 | $10.42 | $27,144 | 17,965 | Yes | Form 4 |
| Bachrodt AmySVP, Finance | Dec 30, 2025 | Dec 31, 2025 | S | 5,000 | $40.08 | Sale −$200,400 | 12,965 | Yes | Form 4 |
| Bachrodt AmySVP, Finance | Dec 30, 2025 | Dec 31, 2025 | M · derivative | 2,395 | $10.42 | $24,956 | 1 | Yes | Form 4 |
| Bachrodt AmySVP, Finance | Dec 30, 2025 | Dec 31, 2025 | M · derivative | 2,605 | $10.42 | $27,144 | 2,581 | Yes | Form 4 |
| Dandekar AtulCSBO | Dec 29, 2025 | Dec 31, 2025 | M | 72,400 | $10.42 | $754,408 | 82,903 | Yes | Form 4 |
| Dandekar AtulCSBO | Dec 29, 2025 | Dec 31, 2025 | S | 66,365 | $40.51 | Sale −$2,688,446 | 16,538 | Yes | Form 4 |
| Dandekar AtulCSBO | Dec 29, 2025 | Dec 31, 2025 | S | 6,035 | $41.13 | Sale −$248,220 | 10,503 | Yes | Form 4 |
| Dandekar AtulCSBO | Dec 29, 2025 | Dec 31, 2025 | M · derivative | 72,400 | $10.42 | $754,408 | 74,243 | Yes | Form 4 |
| Bernstein HaroldPresident, R&D & CMO | Dec 29, 2025 | Dec 31, 2025 | M | 45,000 | $10.42 | $468,900 | 45,000 | Yes | Form 4 |
| Bernstein HaroldPresident, R&D & CMO | Dec 29, 2025 | Dec 31, 2025 | S | 27,800 | $40.34 | Sale −$1,121,452 | 17,200 | Yes | Form 4 |
| Bernstein HaroldPresident, R&D & CMO | Dec 29, 2025 | Dec 31, 2025 | S | 17,200 | $40.93 | Sale −$703,996 | not reported | Yes | Form 4 |
| Bernstein HaroldPresident, R&D & CMO | Dec 29, 2025 | Dec 31, 2025 | M · derivative | 45,000 | $10.42 | $468,900 | 342,407 | Yes | Form 4 |
| Bachrodt AmySVP, Finance | Dec 29, 2025 | Dec 31, 2025 | M | 124 | $10.42 | $1,292 | 13,089 | Yes | Form 4 |
| Bachrodt AmySVP, Finance | Dec 29, 2025 | Dec 31, 2025 | M | 9,876 | $10.42 | $102,908 | 22,965 | Yes | Form 4 |
| Bachrodt AmySVP, Finance | Dec 29, 2025 | Dec 31, 2025 | S | 9,400 | $40.54 | Sale −$381,076 | 13,565 | Yes | Form 4 |
| Bachrodt AmySVP, Finance | Dec 29, 2025 | Dec 31, 2025 | S | 600 | $41.16 | Sale −$24,696 | 12,965 | Yes | Form 4 |
| Bachrodt AmySVP, Finance | Dec 29, 2025 | Dec 31, 2025 | M · derivative | 124 | $10.42 | $1,292 | 2,396 | Yes | Form 4 |
| Bachrodt AmySVP, Finance | Dec 29, 2025 | Dec 31, 2025 | M · derivative | 9,876 | $10.42 | $102,908 | 23,834 | Yes | Form 4 |
| Homcy Charles J | Nov 19, 2025 | Nov 21, 2025 | J | 1,489 | $0.00 | $0 | 31,113 | No | Form 4 |
| Third Rock Ventures GP V, LP | Nov 4, 2025 | Nov 5, 2025 | J | 1,600,000 | not reported | not reported | 4,473,958 | No | Form 4 |
| Homcy Charles J | Oct 23, 2025 | Oct 27, 2025 | G | 28,423 | $0.00 | $0 | 29,624 | No | Form 4 |
| Hoppenot Herve | Oct 6, 2025 | Oct 7, 2025 | A · derivative | 36,000 | $27.52 | $990,720 | 36,000 | No | Form 4 |
| Homcy Charles J | Sep 22, 2025 | Sep 24, 2025 | A · derivative | 18,000 | $23.67 | $426,060 | 18,000 | No | Form 4 |
| Scheller Richard H | Sep 22, 2025 | Sep 24, 2025 | A · derivative | 18,000 | $23.67 | $426,060 | 18,000 | No | Form 4 |
| Spiegelman Daniel K | Sep 22, 2025 | Sep 24, 2025 | A · derivative | 18,000 | $23.67 | $426,060 | 18,000 | No | Form 4 |
| Lim Jonathan E | Sep 22, 2025 | Sep 24, 2025 | A · derivative | 18,000 | $23.67 | $426,060 | 18,000 | No | Form 4 |
| Sohn Catherine A. | Sep 22, 2025 | Sep 24, 2025 | A · derivative | 18,000 | $23.67 | $426,060 | 18,000 | No | Form 4 |
| Exter Neil | Sep 22, 2025 | Sep 24, 2025 | A · derivative | 18,000 | $23.67 | $426,060 | 18,000 | No | Form 4 |
| Coloma Jason VChief Executive Officer | Sep 22, 2025 | Sep 24, 2025 | A · derivative | 100,000 | $0.00 | $0 | 100,000 | No | Form 4 |
| Courtney PhillipsGC and Corp. Secretary | Sep 22, 2025 | Sep 24, 2025 | A · derivative | 22,000 | $0.00 | $0 | 22,000 | No | Form 4 |
| Andrews Nancy C | Sep 22, 2025 | Sep 24, 2025 | A · derivative | 18,000 | $23.67 | $426,060 | 18,000 | No | Form 4 |
| Kathiresan Sekar | Sep 22, 2025 | Sep 24, 2025 | A · derivative | 18,000 | $23.67 | $426,060 | 18,000 | No | Form 4 |
| Dandekar AtulCSBO | Sep 22, 2025 | Sep 24, 2025 | A · derivative | 25,000 | $0.00 | $0 | 25,000 | No | Form 4 |
| Bernstein HaroldPresident, R&D & CMO | Sep 22, 2025 | Sep 24, 2025 | A · derivative | 40,000 | $0.00 | $0 | 40,000 | No | Form 4 |
| Bachrodt AmySVP, Finance | Sep 22, 2025 | Sep 24, 2025 | A · derivative | 22,000 | $0.00 | $0 | 22,000 | No | Form 4 |
| Scheller Richard H | Sep 15, 2025 | Sep 16, 2025 | S | 20,744 | $22.37 | Sale −$464,043 | not reported | No | Form 4 |
| Tahir MisbahChief Financial Officer | Sep 2, 2025 | Sep 2, 2025 | A · derivative | 325,000 | $15.32 | $4,979,000 | 325,000 | No | Form 4 |
| Exter Neil | Aug 17, 2025 | Aug 19, 2025 | A · derivative | 16,000 | $13.35 | $213,600 | 16,000 | No | Form 4 |
| Third Rock Ventures IV, L.P. | Feb 3, 2025 | Feb 4, 2025 | C | 5,762,788 | $0.00 | $0 | 6,073,958 | No | Form 4 |
| Third Rock Ventures IV, L.P. | Feb 3, 2025 | Feb 4, 2025 | C | 950,800 | $0.00 | $0 | 950,800 | No | Form 4 |
| Third Rock Ventures IV, L.P. | Feb 3, 2025 | Feb 4, 2025 | C · derivative | 45,833,334 | $0.00 | $0 | not reported | No | Form 4 |
| Third Rock Ventures IV, L.P. | Feb 3, 2025 | Feb 4, 2025 | C · derivative | 9,725,709 | $0.00 | $0 | not reported | No | Form 4 |
| Third Rock Ventures IV, L.P. | Feb 3, 2025 | Feb 4, 2025 | C · derivative | 9,166,666 | $0.00 | $0 | not reported | No | Form 4 |
| Homcy Charles J | Feb 3, 2025 | Feb 4, 2025 | C | 8,807 | not reported | not reported | 37,330 | No | Form 4 |
| Homcy Charles J | Feb 3, 2025 | Feb 4, 2025 | C | 20,717 | not reported | not reported | 58,047 | No | Form 4 |
| Homcy Charles J | Feb 3, 2025 | Feb 4, 2025 | C | 7,422 | not reported | not reported | 7,422 | No | Form 4 |
| Homcy Charles J | Feb 3, 2025 | Feb 4, 2025 | C · derivative | 72,727 | not reported | not reported | not reported | No | Form 4 |
| Homcy Charles J | Feb 3, 2025 | Feb 4, 2025 | C · derivative | 169,405 | not reported | not reported | not reported | No | Form 4 |
| Homcy Charles J | Feb 3, 2025 | Feb 4, 2025 | C · derivative | 71,564 | not reported | not reported | not reported | No | Form 4 |
| Lim Jonathan E | Feb 3, 2025 | Feb 4, 2025 | C | 37,724 | not reported | not reported | 37,724 | No | Form 4 |
| Lim Jonathan E | Feb 3, 2025 | Feb 4, 2025 | C | 270,232 | not reported | not reported | 307,956 | No | Form 4 |
| Lim Jonathan E | Feb 3, 2025 | Feb 4, 2025 | C · derivative | 363,703 | not reported | not reported | not reported | No | Form 4 |
| Lim Jonathan E | Feb 3, 2025 | Feb 4, 2025 | C · derivative | 2,231,381 | not reported | not reported | not reported | No | Form 4 |
| Homcy Charles J | Dec 9, 2024 | Feb 4, 2025 | A · derivative | 80,385 | $10.42 | $837,612 | not reported | No | Form 4 |
| Homcy Charles J | Dec 9, 2024 | Feb 4, 2025 | D · derivative | 5,704 | $11.19 | $63,828 | 5,704 | No | Form 4 |
| Homcy Charles J | Dec 9, 2024 | Feb 4, 2025 | A · derivative | 5,704 | $10.42 | $59,436 | not reported | No | Form 4 |
| Homcy Charles J | Dec 9, 2024 | Feb 4, 2025 | D · derivative | 46,675 | $17.74 | $828,015 | 46,675 | No | Form 4 |
| Homcy Charles J | Dec 9, 2024 | Feb 4, 2025 | A · derivative | 46,675 | $10.42 | $486,354 | not reported | No | Form 4 |
| Homcy Charles J | Dec 9, 2024 | Feb 4, 2025 | D · derivative | 45,638 | $14.08 | $642,583 | 45,638 | No | Form 4 |
| Homcy Charles J | Dec 9, 2024 | Feb 4, 2025 | A · derivative | 45,638 | $10.42 | $475,548 | not reported | No | Form 4 |
| Lim Jonathan E | Dec 9, 2024 | Feb 4, 2025 | A · derivative | 5,704 | $10.42 | $59,436 | 5,704 | No | Form 4 |
| Lim Jonathan E | Dec 9, 2024 | Feb 4, 2025 | D · derivative | 5,704 | $17.74 | $101,189 | not reported | No | Form 4 |
| Lim Jonathan E | Dec 9, 2024 | Feb 4, 2025 | A · derivative | 9,086 | $10.42 | $94,676 | 9,086 | No | Form 4 |
| Homcy Charles J | Nov 26, 2024 | Feb 4, 2025 | C · derivative | 71,564 | not reported | not reported | 7,422 | No | Form 4 |
| Homcy Charles J | Nov 26, 2024 | Feb 4, 2025 | C · derivative | 80,385 | $78,961.64 | $6,347,331,431 | 80,385 | No | Form 4 |