MGNXMACROGENICS INC
- Market cap
- $143.33M
- as of 2026-10-23
- Latest close
- $2.25
- as of 2026-10-23
- Sector
- Healthcare
- as of 2026-10-24
- Industry
- Biotechnology
- as of 2026-10-24
Cluster
No cluster in the last 90 days under the default rule (14d · ≥2 insiders · all roles).
Form 4 historysince 2023-10-04
Dashed line = amended filing (Form 4/A)
| Insider | Traded | Filed | Type | Shares | Price | Value | Owned after | 10b5-1 plan | Filing |
|---|---|---|---|---|---|---|---|---|---|
| Bonvini EzioSr VP, Research & CSO | Oct 6 | Oct 7 | M | 8,000 | $2.60 | $20,800 | 193,799 | No | Form 4 |
| Bonvini EzioSr VP, Research & CSO | Oct 6 | Oct 7 | M · derivative | 8,000 | $2.60 | $20,800 | 80,000 | No | Form 4 |
| Peters Jeffrey StuartSenior VP, GC, and Secretary | Aug 19 | Aug 20 | S | 31,105 | $4.15 | Sale −$129,086 | not reported | Yes | Form 4 |
| Bonvini EzioSr VP, Research & CSO | Aug 17 | Aug 18 | M | 40,000 | $2.60 | $104,000 | 185,799 | No | Form 4 |
| Bonvini EzioSr VP, Research & CSO | Aug 17 | Aug 18 | M · derivative | 40,000 | $2.60 | $104,000 | 88,000 | No | Form 4 |
| O'Brien Federica F. | May 19 | May 20 | A · derivative | 22,000 | $4.52 | $99,440 | 22,000 | No | Form 4 |
| O'Brien Federica F. | May 19 | May 20 | A · derivative | 3,750 | $0.00 | $0 | 3,750 | No | Form 4 |
| Stump David C | May 19 | May 20 | A · derivative | 3,750 | $0.00 | $0 | 3,750 | No | Form 4 |
| Stump David C | May 19 | May 20 | A · derivative | 22,000 | $4.52 | $99,440 | 22,000 | No | Form 4 |
| Hurwitz Edward | May 19 | May 20 | A · derivative | 3,750 | $0.00 | $0 | 3,750 | No | Form 4 |
| Hurwitz Edward | May 19 | May 20 | A · derivative | 22,000 | $4.52 | $99,440 | 22,000 | No | Form 4 |
| Heiden William K | May 19 | May 20 | A · derivative | 3,750 | $0.00 | $0 | 3,750 | No | Form 4 |
| Heiden William K | May 19 | May 20 | A · derivative | 22,000 | $4.52 | $99,440 | 22,000 | No | Form 4 |
| Liu Margaret | May 19 | May 20 | A · derivative | 3,750 | $0.00 | $0 | 3,750 | No | Form 4 |
| Liu Margaret | May 19 | May 20 | A · derivative | 22,000 | $4.52 | $99,440 | 22,000 | No | Form 4 |
| Chhabra Meenu | May 19 | May 20 | A · derivative | 22,000 | $4.52 | $99,440 | 22,000 | No | Form 4 |
| Chhabra Meenu | May 19 | May 20 | A · derivative | 3,750 | $0.00 | $0 | 3,750 | No | Form 4 |
| Jackson Scott Thomas | May 19 | May 20 | A · derivative | 3,750 | $0.00 | $0 | 3,750 | No | Form 4 |
| Jackson Scott Thomas | May 19 | May 20 | A · derivative | 22,000 | $4.52 | $99,440 | 22,000 | No | Form 4 |
| Koenig Scott | May 19 | May 20 | A · derivative | 3,750 | $0.00 | $0 | 3,750 | No | Form 4 |
| Koenig Scott | May 19 | May 20 | A · derivative | 22,000 | $4.52 | $99,440 | 22,000 | No | Form 4 |
| Ferrante Karen Jean | May 19 | May 20 | A · derivative | 3,750 | $0.00 | $0 | 3,750 | No | Form 4 |
| Ferrante Karen Jean | May 19 | May 20 | A · derivative | 22,000 | $4.52 | $99,440 | 22,000 | No | Form 4 |
| O'Brien Federica F. | May 18 | May 20 | M | 3,750 | not reported | not reported | 14,750 | No | Form 4 |
| O'Brien Federica F. | May 18 | May 20 | M · derivative | 3,750 | $0.00 | $0 | not reported | No | Form 4 |
| Stump David C | May 18 | May 20 | M | 3,750 | not reported | not reported | 14,750 | No | Form 4 |
| Stump David C | May 18 | May 20 | M · derivative | 3,750 | $0.00 | $0 | not reported | No | Form 4 |
| Hurwitz Edward | May 18 | May 20 | M | 3,750 | not reported | not reported | 47,824 | No | Form 4 |
| Hurwitz Edward | May 18 | May 20 | M · derivative | 3,750 | $0.00 | $0 | not reported | No | Form 4 |
| Heiden William K | May 18 | May 20 | M | 3,750 | not reported | not reported | 114,750 | No | Form 4 |
| Heiden William K | May 18 | May 20 | M · derivative | 3,750 | $0.00 | $0 | not reported | No | Form 4 |
| Liu Margaret | May 18 | May 20 | M | 3,750 | not reported | not reported | 14,750 | No | Form 4 |
| Liu Margaret | May 18 | May 20 | M · derivative | 3,750 | $0.00 | $0 | not reported | No | Form 4 |
| Chhabra Meenu | May 18 | May 20 | M | 3,750 | not reported | not reported | 14,750 | No | Form 4 |
| Chhabra Meenu | May 18 | May 20 | M · derivative | 3,750 | $0.00 | $0 | not reported | No | Form 4 |
| Jackson Scott Thomas | May 18 | May 20 | M | 3,750 | not reported | not reported | 14,750 | No | Form 4 |
| Jackson Scott Thomas | May 18 | May 20 | M · derivative | 3,750 | $0.00 | $0 | not reported | No | Form 4 |
| Ferrante Karen Jean | May 18 | May 20 | M | 3,750 | not reported | not reported | 14,750 | No | Form 4 |
| Ferrante Karen Jean | May 18 | May 20 | M · derivative | 3,750 | $0.00 | $0 | not reported | No | Form 4 |
| Siegel Jay Philip | May 18 | May 20 | M | 3,750 | not reported | not reported | 14,750 | No | Form 4 |
| Siegel Jay Philip | May 18 | May 20 | M · derivative | 3,750 | $0.00 | $0 | not reported | No | Form 4 |
| Karrels JamesSVP and CFO | Feb 15 | Feb 17 | M | 14,999 | not reported | not reported | 211,827 | No | Form 4 |
| Karrels JamesSVP and CFO | Feb 15 | Feb 17 | F | 5,790 | $1.71 | $9,901 | 206,037 | No | Form 4 |
| Karrels JamesSVP and CFO | Feb 15 | Feb 17 | M · derivative | 14,999 | $0.00 | $0 | not reported | No | Form 4 |
| Koenig Scott | Feb 15 | Feb 17 | M | 21,165 | $0.00 | $0 | 867,240 | No | Form 4 |
| Koenig Scott | Feb 15 | Feb 17 | M · derivative | 21,165 | $0.00 | $0 | not reported | No | Form 4 |
| Risser Eric BlasiusPresident and CEO | Feb 15 | Feb 17 | M | 16,665 | not reported | not reported | 83,602 | No | Form 4 |
| Risser Eric BlasiusPresident and CEO | Feb 15 | Feb 17 | F | 6,433 | $1.71 | $11,000 | 77,169 | No | Form 4 |
| Risser Eric BlasiusPresident and CEO | Feb 15 | Feb 17 | M · derivative | 16,665 | $0.00 | $0 | not reported | No | Form 4 |
| Bonvini EzioSr VP, Research & CSO | Feb 15 | Feb 17 | M | 16,665 | not reported | not reported | 152,232 | No | Form 4 |
| Bonvini EzioSr VP, Research & CSO | Feb 15 | Feb 17 | F | 6,433 | $1.71 | $11,000 | 145,799 | No | Form 4 |
| Bonvini EzioSr VP, Research & CSO | Feb 15 | Feb 17 | M · derivative | 16,665 | $0.00 | $0 | not reported | No | Form 4 |
| Spitznagel ThomasSr VP, Technical Ops | Feb 15 | Feb 17 | M | 13,332 | not reported | not reported | 44,063 | No | Form 4 |
| Spitznagel ThomasSr VP, Technical Ops | Feb 15 | Feb 17 | F | 5,520 | $1.71 | $9,439 | 38,543 | No | Form 4 |
| Spitznagel ThomasSr VP, Technical Ops | Feb 15 | Feb 17 | M · derivative | 13,332 | $0.00 | $0 | not reported | No | Form 4 |
| Peters Jeffrey StuartSenior VP, GC, and Secretary | Feb 15 | Feb 17 | M | 13,332 | not reported | not reported | 36,252 | No | Form 4 |
| Peters Jeffrey StuartSenior VP, GC, and Secretary | Feb 15 | Feb 17 | F | 5,147 | $1.71 | $8,801 | 31,105 | No | Form 4 |
| Peters Jeffrey StuartSenior VP, GC, and Secretary | Feb 15 | Feb 17 | M · derivative | 13,332 | $0.00 | $0 | not reported | No | Form 4 |
| Smith Beth AnnVP, Controller & Treasurer | Feb 15 | Feb 17 | M | 1,095 | not reported | not reported | 13,204 | No | Form 4 |
| Smith Beth AnnVP, Controller & Treasurer | Feb 15 | Feb 17 | F | 423 | $1.71 | $723 | 12,781 | No | Form 4 |
| Smith Beth AnnVP, Controller & Treasurer | Feb 15 | Feb 17 | M · derivative | 1,095 | $0.00 | $0 | not reported | No | Form 4 |
| Karrels JamesSVP and CFO | Feb 12 | Feb 17 | A · derivative | 150,000 | $1.71 | $256,500 | 150,000 | No | Form 4 |
| Karrels JamesSVP and CFO | Feb 12 | Feb 17 | A · derivative | 25,000 | $0.00 | $0 | 25,000 | No | Form 4 |
| Risser Eric BlasiusPresident and CEO | Feb 12 | Feb 17 | A · derivative | 100,000 | $0.00 | $0 | 100,000 | No | Form 4 |
| Risser Eric BlasiusPresident and CEO | Feb 12 | Feb 17 | A · derivative | 595,000 | $1.71 | $1,017,450 | 595,000 | No | Form 4 |
| Bonvini EzioSr VP, Research & CSO | Feb 12 | Feb 17 | A · derivative | 31,250 | $0.00 | $0 | 31,250 | No | Form 4 |
| Bonvini EzioSr VP, Research & CSO | Feb 12 | Feb 17 | A · derivative | 187,500 | $1.71 | $320,625 | 187,500 | No | Form 4 |
| Spitznagel ThomasSr VP, Technical Ops | Feb 12 | Feb 17 | A · derivative | 25,000 | $0.00 | $0 | 25,000 | No | Form 4 |
| Spitznagel ThomasSr VP, Technical Ops | Feb 12 | Feb 17 | A · derivative | 150,000 | $1.71 | $256,500 | 150,000 | No | Form 4 |
| Peters Jeffrey StuartSenior VP, GC, and Secretary | Feb 12 | Feb 17 | A · derivative | 150,000 | $1.71 | $256,500 | 150,000 | No | Form 4 |
| Peters Jeffrey StuartSenior VP, GC, and Secretary | Feb 12 | Feb 17 | A · derivative | 25,000 | $0.00 | $0 | 25,000 | No | Form 4 |
| Smith Beth AnnVP, Controller & Treasurer | Feb 12 | Feb 17 | A · derivative | 15,625 | $0.00 | $0 | 15,625 | No | Form 4 |
| Smith Beth AnnVP, Controller & Treasurer | Feb 12 | Feb 17 | A · derivative | 93,750 | $1.71 | $160,313 | 93,750 | No | Form 4 |
| Karrels JamesSVP and CFO | Feb 8 | Feb 10 | M | 9,999 | not reported | not reported | 200,688 | No | Form 4 |
| Karrels JamesSVP and CFO | Feb 8 | Feb 10 | F | 3,860 | $1.81 | $6,987 | 196,828 | No | Form 4 |
| Karrels JamesSVP and CFO | Feb 8 | Feb 10 | M · derivative | 9,999 | $0.00 | $0 | 9,999 | No | Form 4 |
| Koenig Scott | Feb 8 | Feb 10 | M | 15,831 | not reported | not reported | 846,075 | No | Form 4 |
| Koenig Scott | Feb 8 | Feb 10 | M · derivative | 15,831 | $0.00 | $0 | 15,832 | No | Form 4 |
| Risser Eric BlasiusPresident and CEO | Feb 8 | Feb 10 | M | 11,166 | not reported | not reported | 71,248 | No | Form 4 |
| Risser Eric BlasiusPresident and CEO | Feb 8 | Feb 10 | F | 4,311 | $1.81 | $7,803 | 66,937 | No | Form 4 |
| Risser Eric BlasiusPresident and CEO | Feb 8 | Feb 10 | M · derivative | 11,166 | $0.00 | $0 | 11,166 | No | Form 4 |
| Bonvini EzioSr VP, Research & CSO | Feb 8 | Feb 10 | M | 11,166 | not reported | not reported | 139,878 | No | Form 4 |
| Bonvini EzioSr VP, Research & CSO | Feb 8 | Feb 10 | F | 4,311 | $1.81 | $7,803 | 135,567 | No | Form 4 |
| Bonvini EzioSr VP, Research & CSO | Feb 8 | Feb 10 | M · derivative | 11,166 | $0.00 | $0 | 11,166 | No | Form 4 |
| Spitznagel ThomasSr VP, Technical Ops | Feb 8 | Feb 10 | M | 8,999 | not reported | not reported | 33,917 | No | Form 4 |
| Spitznagel ThomasSr VP, Technical Ops | Feb 8 | Feb 10 | F | 3,186 | $1.81 | $5,767 | 30,731 | No | Form 4 |
| Spitznagel ThomasSr VP, Technical Ops | Feb 8 | Feb 10 | M · derivative | 8,999 | $0.00 | $0 | 9,000 | No | Form 4 |
| Peters Jeffrey StuartSenior VP, GC, and Secretary | Feb 8 | Feb 10 | M | 8,999 | not reported | not reported | 26,394 | No | Form 4 |
| Peters Jeffrey StuartSenior VP, GC, and Secretary | Feb 8 | Feb 10 | F | 3,474 | $1.81 | $6,288 | 22,920 | No | Form 4 |
| Peters Jeffrey StuartSenior VP, GC, and Secretary | Feb 8 | Feb 10 | M · derivative | 8,999 | $0.00 | $0 | 9,000 | No | Form 4 |
| Smith Beth AnnVP, Controller & Treasurer | Feb 8 | Feb 10 | M | 1,583 | not reported | not reported | 12,721 | No | Form 4 |
| Smith Beth AnnVP, Controller & Treasurer | Feb 8 | Feb 10 | F | 612 | $1.81 | $1,108 | 12,109 | No | Form 4 |
| Smith Beth AnnVP, Controller & Treasurer | Feb 8 | Feb 10 | M · derivative | 1,583 | $0.00 | $0 | 1,584 | No | Form 4 |
| Karrels JamesSVP and CFO | Feb 7 | Feb 10 | M | 6,334 | not reported | not reported | 193,135 | No | Form 4 |
| Karrels JamesSVP and CFO | Feb 7 | Feb 10 | F | 2,446 | $1.81 | $4,427 | 190,689 | No | Form 4 |
| Karrels JamesSVP and CFO | Feb 7 | Feb 10 | M · derivative | 6,334 | $0.00 | $0 | 12,666 | No | Form 4 |
| Risser Eric BlasiusPresident and CEO | Feb 7 | Feb 10 | M | 6,668 | not reported | not reported | 62,657 | No | Form 4 |
| Risser Eric BlasiusPresident and CEO | Feb 7 | Feb 10 | F | 2,575 | $1.81 | $4,661 | 60,082 | No | Form 4 |
| Risser Eric BlasiusPresident and CEO | Feb 7 | Feb 10 | M · derivative | 6,668 | $0.00 | $0 | 13,332 | No | Form 4 |
| Bonvini EzioSr VP, Research & CSO | Feb 7 | Feb 10 | M | 7,001 | not reported | not reported | 131,415 | No | Form 4 |
| Bonvini EzioSr VP, Research & CSO | Feb 7 | Feb 10 | F | 2,703 | $1.81 | $4,892 | 128,712 | No | Form 4 |
| Bonvini EzioSr VP, Research & CSO | Feb 7 | Feb 10 | M · derivative | 7,001 | $0.00 | $0 | 13,999 | No | Form 4 |
| Spitznagel ThomasSr VP, Technical Ops | Feb 7 | Feb 10 | M | 6,001 | not reported | not reported | 27,403 | No | Form 4 |
| Spitznagel ThomasSr VP, Technical Ops | Feb 7 | Feb 10 | F | 2,485 | $1.81 | $4,498 | 24,918 | No | Form 4 |
| Spitznagel ThomasSr VP, Technical Ops | Feb 7 | Feb 10 | M · derivative | 6,001 | $0.00 | $0 | 11,999 | No | Form 4 |
| Peters Jeffrey StuartSenior VP, GC, and Secretary | Feb 7 | Feb 10 | M | 6,001 | not reported | not reported | 19,712 | No | Form 4 |
| Peters Jeffrey StuartSenior VP, GC, and Secretary | Feb 7 | Feb 10 | F | 2,317 | $1.81 | $4,194 | 17,395 | No | Form 4 |
| Peters Jeffrey StuartSenior VP, GC, and Secretary | Feb 7 | Feb 10 | M · derivative | 6,001 | $0.00 | $0 | 11,999 | No | Form 4 |
| Smith Beth AnnVP, Controller & Treasurer | Feb 7 | Feb 10 | M | 2,617 | not reported | not reported | 12,149 | No | Form 4 |
| Smith Beth AnnVP, Controller & Treasurer | Feb 7 | Feb 10 | F | 1,011 | $1.81 | $1,830 | 11,138 | No | Form 4 |
| Smith Beth AnnVP, Controller & Treasurer | Feb 7 | Feb 10 | M · derivative | 2,617 | $0.00 | $0 | 5,233 | No | Form 4 |
| Smith Beth AnnVP, Controller & Treasurer | Dec 8, 2025 | Dec 10, 2025 | A · derivative | 25,000 | $1.33 | $33,250 | 25,000 | No | Form 4 |
| Heiden William K | Aug 20, 2025 | Aug 21, 2025 | P | 49,500 | $1.49 | Purchase +$73,755 | 111,000 | No | Form 4 |
| Heiden William K | Aug 19, 2025 | Aug 21, 2025 | P | 50,500 | $1.52 | Purchase +$76,760 | 61,500 | No | Form 4 |
| Spitznagel ThomasSr VP, Technical Ops | Aug 15, 2025 | Aug 19, 2025 | A · derivative | 30,000 | $1.58 | $47,400 | 30,000 | No | Form 4 |
| Peters Jeffrey StuartSenior VP and General Counsel | Aug 15, 2025 | Aug 19, 2025 | A · derivative | 30,000 | $1.58 | $47,400 | 30,000 | No | Form 4 |
| Koenig Scott | Aug 13, 2025 | Aug 15, 2025 | M | 21,165 | $0.00 | $0 | 798,580 | No | Form 4 |
| Koenig Scott | Aug 13, 2025 | Aug 15, 2025 | M | 31,664 | $0.00 | $0 | 830,244 | No | Form 4 |
| Koenig Scott | Aug 13, 2025 | Aug 15, 2025 | M · derivative | 21,165 | $0.00 | $0 | 21,165 | No | Form 4 |
| Koenig Scott | Aug 13, 2025 | Aug 15, 2025 | M · derivative | 31,664 | $0.00 | $0 | 31,663 | No | Form 4 |
| Risser Eric BlasiusPresident and CEO | Aug 13, 2025 | Aug 15, 2025 | A · derivative | 550,000 | $1.66 | $913,000 | 550,000 | No | Form 4 |
| Siegel Jay Philip | May 21, 2025 | May 22, 2025 | A · derivative | 3,750 | $0.00 | $0 | 3,750 | No | Form 4 |
| Siegel Jay Philip | May 21, 2025 | May 22, 2025 | A · derivative | 22,000 | $1.49 | $32,780 | 22,000 | No | Form 4 |
| Chhabra Meenu | May 21, 2025 | May 22, 2025 | A · derivative | 3,750 | $0.00 | $0 | 3,750 | No | Form 4 |
| Chhabra Meenu | May 21, 2025 | May 22, 2025 | A · derivative | 22,000 | $1.49 | $32,780 | 22,000 | No | Form 4 |
| Chhabra Meenu | May 21, 2025 | May 22, 2025 | A · derivative | 49,213 | $1.27 | $62,501 | 71,213 | No | Form 4 |
| Hurwitz Edward | May 21, 2025 | May 22, 2025 | A · derivative | 3,750 | $0.00 | $0 | 3,750 | No | Form 4 |
| Hurwitz Edward | May 21, 2025 | May 22, 2025 | A · derivative | 22,000 | $1.49 | $32,780 | 22,000 | No | Form 4 |
| Liu Margaret | May 21, 2025 | May 22, 2025 | A · derivative | 3,750 | $0.00 | $0 | 3,750 | No | Form 4 |
| Liu Margaret | May 21, 2025 | May 22, 2025 | A · derivative | 22,000 | $1.49 | $32,780 | 22,000 | No | Form 4 |
| Ferrante Karen Jean | May 21, 2025 | May 22, 2025 | A · derivative | 3,750 | $0.00 | $0 | 3,750 | No | Form 4 |
| Ferrante Karen Jean | May 21, 2025 | May 22, 2025 | A · derivative | 22,000 | $1.49 | $32,780 | 22,000 | No | Form 4 |
| Stump David C | May 21, 2025 | May 22, 2025 | A · derivative | 3,750 | $0.00 | $0 | 3,750 | No | Form 4 |
| Stump David C | May 21, 2025 | May 22, 2025 | A · derivative | 22,000 | $1.49 | $32,780 | 22,000 | No | Form 4 |
| Heiden William K | May 21, 2025 | May 22, 2025 | A · derivative | 3,750 | $0.00 | $0 | 3,750 | No | Form 4 |
| Heiden William K | May 21, 2025 | May 22, 2025 | A · derivative | 22,000 | $1.49 | $32,780 | 22,000 | No | Form 4 |
| Jackson Scott Thomas | May 21, 2025 | May 22, 2025 | A · derivative | 3,750 | $0.00 | $0 | 3,750 | No | Form 4 |
| Jackson Scott Thomas | May 21, 2025 | May 22, 2025 | A · derivative | 22,000 | $1.49 | $32,780 | 22,000 | No | Form 4 |
| O'Brien Federica F. | May 21, 2025 | May 22, 2025 | A · derivative | 3,750 | $0.00 | $0 | 3,750 | No | Form 4 |
| O'Brien Federica F. | May 21, 2025 | May 22, 2025 | A · derivative | 22,000 | $1.49 | $32,780 | 22,000 | No | Form 4 |
| O'Brien Federica F. | May 21, 2025 | May 22, 2025 | A · derivative | 64,961 | $1.27 | $82,500 | 86,961 | No | Form 4 |
| Siegel Jay Philip | May 20, 2025 | May 22, 2025 | M | 6,500 | not reported | not reported | 11,000 | No | Form 4 |
| Siegel Jay Philip | May 20, 2025 | May 22, 2025 | M · derivative | 6,500 | $0.00 | $0 | not reported | No | Form 4 |
| Chhabra Meenu | May 20, 2025 | May 22, 2025 | M | 6,500 | not reported | not reported | 11,000 | No | Form 4 |
| Chhabra Meenu | May 20, 2025 | May 22, 2025 | M · derivative | 6,500 | $0.00 | $0 | not reported | No | Form 4 |
| Hurwitz Edward | May 20, 2025 | May 22, 2025 | M | 6,500 | not reported | not reported | 44,074 | No | Form 4 |
| Hurwitz Edward | May 20, 2025 | May 22, 2025 | M · derivative | 6,500 | $0.00 | $0 | not reported | No | Form 4 |
| Liu Margaret | May 20, 2025 | May 22, 2025 | M | 6,500 | not reported | not reported | 11,000 | No | Form 4 |
| Liu Margaret | May 20, 2025 | May 22, 2025 | M · derivative | 6,500 | $0.00 | $0 | not reported | No | Form 4 |
| Ferrante Karen Jean | May 20, 2025 | May 22, 2025 | M | 6,500 | not reported | not reported | 11,000 | No | Form 4 |
| Ferrante Karen Jean | May 20, 2025 | May 22, 2025 | M · derivative | 6,500 | $0.00 | $0 | not reported | No | Form 4 |
| Stump David C | May 20, 2025 | May 22, 2025 | M | 6,500 | not reported | not reported | 11,000 | No | Form 4 |
| Stump David C | May 20, 2025 | May 22, 2025 | M · derivative | 6,500 | $0.00 | $0 | not reported | No | Form 4 |
| Heiden William K | May 20, 2025 | May 22, 2025 | M | 6,500 | not reported | not reported | 11,000 | No | Form 4 |
| Heiden William K | May 20, 2025 | May 22, 2025 | M · derivative | 6,500 | $0.00 | $0 | not reported | No | Form 4 |
| Jackson Scott Thomas | May 20, 2025 | May 22, 2025 | M | 6,500 | not reported | not reported | 11,000 | No | Form 4 |
| Jackson Scott Thomas | May 20, 2025 | May 22, 2025 | M · derivative | 6,500 | $0.00 | $0 | not reported | No | Form 4 |
| O'Brien Federica F. | May 20, 2025 | May 22, 2025 | M | 6,500 | not reported | not reported | 11,000 | No | Form 4 |
| O'Brien Federica F. | May 20, 2025 | May 22, 2025 | M · derivative | 6,500 | $0.00 | $0 | not reported | No | Form 4 |
| Eck Stephen L.Chief Medical Officer | Feb 15, 2025 | Feb 19, 2025 | M | 16,665 | $0.00 | $0 | 34,319 | No | Form 4 |
| Eck Stephen L.Chief Medical Officer | Feb 15, 2025 | Feb 19, 2025 | F | 4,942 | $2.56 | $12,652 | 29,377 | No | Form 4 |
| Eck Stephen L.Chief Medical Officer | Feb 15, 2025 | Feb 19, 2025 | M · derivative | 16,665 | $0.00 | $0 | 16,665 | No | Form 4 |
| Spitznagel ThomasSr VP, Technical Ops | Feb 15, 2025 | Feb 19, 2025 | M | 13,332 | $0.00 | $0 | 26,922 | No | Form 4 |
| Spitznagel ThomasSr VP, Technical Ops | Feb 15, 2025 | Feb 19, 2025 | F | 5,520 | $2.56 | $14,131 | 21,402 | No | Form 4 |
| Spitznagel ThomasSr VP, Technical Ops | Feb 15, 2025 | Feb 19, 2025 | M · derivative | 13,332 | $0.00 | $0 | 13,332 | No | Form 4 |
| Smith Beth AnnVP, Controller & Treasurer | Feb 15, 2025 | Feb 19, 2025 | M | 1,095 | $0.00 | $0 | 9,955 | No | Form 4 |
| Smith Beth AnnVP, Controller & Treasurer | Feb 15, 2025 | Feb 19, 2025 | S | 423 | $2.56 | Sale −$1,083 | 9,532 | No | Form 4 |
| Smith Beth AnnVP, Controller & Treasurer | Feb 15, 2025 | Feb 19, 2025 | M · derivative | 1,095 | $0.00 | $0 | 1,095 | No | Form 4 |
| Risser Eric BlasiusChief Operating Officer | Feb 15, 2025 | Feb 19, 2025 | M | 16,665 | $0.00 | $0 | 62,422 | No | Form 4 |
| Risser Eric BlasiusChief Operating Officer | Feb 15, 2025 | Feb 19, 2025 | F | 6,433 | $2.56 | $16,468 | 55,989 | No | Form 4 |
| Risser Eric BlasiusChief Operating Officer | Feb 15, 2025 | Feb 19, 2025 | M · derivative | 16,665 | $0.00 | $0 | 16,665 | No | Form 4 |
| Peters Jeffrey StuartSenior VP and General Counsel | Feb 15, 2025 | Feb 19, 2025 | M | 13,332 | $0.00 | $0 | 18,858 | No | Form 4 |
| Peters Jeffrey StuartSenior VP and General Counsel | Feb 15, 2025 | Feb 19, 2025 | F | 5,147 | $2.56 | $13,176 | 13,711 | No | Form 4 |
| Peters Jeffrey StuartSenior VP and General Counsel | Feb 15, 2025 | Feb 19, 2025 | M · derivative | 13,332 | $0.00 | $0 | 13,332 | No | Form 4 |
| Koenig ScottPresident and CEO | Feb 15, 2025 | Feb 19, 2025 | M | 42,329 | $0.00 | $0 | 777,415 | No | Form 4 |
| Koenig ScottPresident and CEO | Feb 15, 2025 | Feb 19, 2025 | M · derivative | 42,329 | $0.00 | $0 | 42,330 | No | Form 4 |
| Karrels JamesSVP, CFO and Secretary | Feb 15, 2025 | Feb 19, 2025 | M | 14,998 | $0.00 | $0 | 192,591 | No | Form 4 |
| Karrels JamesSVP, CFO and Secretary | Feb 15, 2025 | Feb 19, 2025 | F | 5,790 | $2.56 | $14,822 | 186,801 | No | Form 4 |
| Karrels JamesSVP, CFO and Secretary | Feb 15, 2025 | Feb 19, 2025 | M · derivative | 14,998 | $0.00 | $0 | 14,999 | No | Form 4 |
| Bonvini EzioSr VP, Research & CSO | Feb 15, 2025 | Feb 19, 2025 | M | 16,665 | $0.00 | $0 | 124,414 | No | Form 4 |
| Bonvini EzioSr VP, Research & CSO | Feb 15, 2025 | Feb 19, 2025 | M · derivative | 16,665 | $0.00 | $0 | 16,665 | No | Form 4 |
| Peters Jeffrey StuartSenior VP and General Counsel | Feb 8, 2025 | Feb 11, 2025 | M | 9,001 | not reported | not reported | 9,001 | No | Form 4 |
| Peters Jeffrey StuartSenior VP and General Counsel | Feb 8, 2025 | Feb 11, 2025 | F | 3,475 | $2.60 | $9,035 | 5,526 | No | Form 4 |
| Peters Jeffrey StuartSenior VP and General Counsel | Feb 8, 2025 | Feb 11, 2025 | M · derivative | 9,001 | $0.00 | $0 | 17,999 | No | Form 4 |
| Spitznagel ThomasSr VP, Technical Ops | Feb 8, 2025 | Feb 11, 2025 | M | 9,001 | not reported | not reported | 17,317 | No | Form 4 |
| Spitznagel ThomasSr VP, Technical Ops | Feb 8, 2025 | Feb 11, 2025 | F | 3,727 | $2.60 | $9,690 | 13,590 | No | Form 4 |
| Spitznagel ThomasSr VP, Technical Ops | Feb 8, 2025 | Feb 11, 2025 | M · derivative | 9,001 | $0.00 | $0 | 17,999 | No | Form 4 |
| Koenig ScottPresident and CEO | Feb 8, 2025 | Feb 11, 2025 | A | 31,673 | $0.00 | $0 | 735,086 | No | Form 4 |
| Koenig ScottPresident and CEO | Feb 8, 2025 | Feb 11, 2025 | M · derivative | 31,673 | $0.00 | $0 | 63,327 | No | Form 4 |
| Smith Beth AnnVP, Controller & Treasurer | Feb 8, 2025 | Feb 11, 2025 | M | 1,583 | not reported | not reported | 9,472 | No | Form 4 |
| Smith Beth AnnVP, Controller & Treasurer | Feb 8, 2025 | Feb 11, 2025 | F | 612 | $2.60 | $1,591 | 8,860 | No | Form 4 |
| Smith Beth AnnVP, Controller & Treasurer | Feb 8, 2025 | Feb 11, 2025 | M · derivative | 1,583 | $0.00 | $0 | 3,167 | No | Form 4 |
| Karrels JamesSVP, CFO and Secretary | Feb 8, 2025 | Feb 11, 2025 | M | 10,002 | not reported | not reported | 181,454 | No | Form 4 |
| Karrels JamesSVP, CFO and Secretary | Feb 8, 2025 | Feb 11, 2025 | F | 3,861 | $2.60 | $10,039 | 177,593 | No | Form 4 |
| Karrels JamesSVP, CFO and Secretary | Feb 8, 2025 | Feb 11, 2025 | M · derivative | 10,002 | $0.00 | $0 | 19,998 | No | Form 4 |
| Risser Eric BlasiusChief Operating Officer | Feb 8, 2025 | Feb 11, 2025 | M | 11,168 | not reported | not reported | 50,068 | No | Form 4 |
| Risser Eric BlasiusChief Operating Officer | Feb 8, 2025 | Feb 11, 2025 | F | 4,311 | $2.60 | $11,209 | 45,757 | No | Form 4 |
| Risser Eric BlasiusChief Operating Officer | Feb 8, 2025 | Feb 11, 2025 | M · derivative | 11,168 | $0.00 | $0 | 22,332 | No | Form 4 |
| Bonvini EzioSr VP, Research & CSO | Feb 8, 2025 | Feb 11, 2025 | M | 11,168 | not reported | not reported | 112,060 | No | Form 4 |
| Bonvini EzioSr VP, Research & CSO | Feb 8, 2025 | Feb 11, 2025 | F | 4,311 | $2.60 | $11,209 | 107,749 | No | Form 4 |
| Bonvini EzioSr VP, Research & CSO | Feb 8, 2025 | Feb 11, 2025 | M · derivative | 11,168 | $0.00 | $0 | 22,332 | No | Form 4 |
| Eck Stephen L.Chief Medical Officer | Feb 8, 2025 | Feb 11, 2025 | M | 11,168 | $0.00 | $0 | 20,966 | No | Form 4 |
| Eck Stephen L.Chief Medical Officer | Feb 8, 2025 | Feb 11, 2025 | F | 3,312 | $2.60 | $8,611 | 17,654 | No | Form 4 |
| Eck Stephen L.Chief Medical Officer | Feb 8, 2025 | Feb 11, 2025 | M · derivative | 11,168 | $0.00 | $0 | 22,332 | No | Form 4 |
| Peters Jeffrey StuartSenior VP and General Counsel | Feb 7, 2025 | Feb 11, 2025 | A · derivative | 105,000 | $2.60 | $273,000 | 105,000 | No | Form 4 |
| Peters Jeffrey StuartSenior VP and General Counsel | Feb 7, 2025 | Feb 11, 2025 | A · derivative | 18,000 | $0.00 | $0 | 18,000 | No | Form 4 |
| Spitznagel ThomasSr VP, Technical Ops | Feb 7, 2025 | Feb 11, 2025 | A · derivative | 105,000 | $2.60 | $273,000 | 105,000 | No | Form 4 |
| Spitznagel ThomasSr VP, Technical Ops | Feb 7, 2025 | Feb 11, 2025 | A · derivative | 18,000 | $0.00 | $0 | 18,000 | No | Form 4 |
| Smith Beth AnnVP, Controller & Treasurer | Feb 7, 2025 | Feb 11, 2025 | A · derivative | 47,050 | $2.60 | $122,330 | 47,050 | No | Form 4 |
| Smith Beth AnnVP, Controller & Treasurer | Feb 7, 2025 | Feb 11, 2025 | A · derivative | 7,850 | $0.00 | $0 | 7,850 | No | Form 4 |
| Karrels JamesSVP, CFO and Secretary | Feb 7, 2025 | Feb 11, 2025 | A · derivative | 113,000 | $2.60 | $293,800 | 113,000 | No | Form 4 |
| Karrels JamesSVP, CFO and Secretary | Feb 7, 2025 | Feb 11, 2025 | A · derivative | 19,000 | $0.00 | $0 | 19,000 | No | Form 4 |
| Risser Eric BlasiusChief Operating Officer | Feb 7, 2025 | Feb 11, 2025 | A · derivative | 120,000 | $2.60 | $312,000 | 120,000 | No | Form 4 |
| Risser Eric BlasiusChief Operating Officer | Feb 7, 2025 | Feb 11, 2025 | A · derivative | 20,000 | $0.00 | $0 | 20,000 | No | Form 4 |
| Bonvini EzioSr VP, Research & CSO | Feb 7, 2025 | Feb 11, 2025 | A · derivative | 128,000 | $2.60 | $332,800 | 128,000 | No | Form 4 |
| Bonvini EzioSr VP, Research & CSO | Feb 7, 2025 | Feb 11, 2025 | A · derivative | 21,000 | $0.00 | $0 | 21,000 | No | Form 4 |
| Eck Stephen L.Chief Medical Officer | Feb 7, 2025 | Feb 11, 2025 | A · derivative | 113,000 | $2.60 | $293,800 | 113,000 | No | Form 4 |
| Eck Stephen L.Chief Medical Officer | Feb 7, 2025 | Feb 11, 2025 | A · derivative | 19,000 | $0.00 | $0 | 19,000 | No | Form 4 |
| Koenig ScottPresident and CEO | Oct 7, 2024 | Oct 9, 2024 | G | 53,265 | not reported | not reported | not reported | No | Form 4 |
| Koenig ScottPresident and CEO | Oct 7, 2024 | Oct 9, 2024 | G | 53,265 | not reported | not reported | 427,480 | No | Form 4 |
| Koenig ScottPresident and CEO | Sep 23, 2024 | Sep 25, 2024 | G | 374,215 | not reported | not reported | 703,413 | No | Form 4 |
| Koenig ScottPresident and CEO | Sep 23, 2024 | Sep 25, 2024 | G | 374,215 | not reported | not reported | 374,215 | No | Form 4 |
| Liu Margaret | May 21, 2024 | May 24, 20244/A | A · derivative | 16,500 | $4.26 | $70,290 | 16,500 | No | Form 4/A |
| Jackson Scott Thomas | May 21, 2024 | May 23, 2024 | A · derivative | 6,500 | $0.00 | $0 | 6,500 | No | Form 4 |
| Jackson Scott Thomas | May 21, 2024 | May 23, 2024 | A · derivative | 16,500 | $4.26 | $70,290 | 16,500 | No | Form 4 |
| Hurwitz Edward | May 21, 2024 | May 23, 2024 | A · derivative | 6,500 | $0.00 | $0 | 6,500 | No | Form 4 |
| Hurwitz Edward | May 21, 2024 | May 23, 2024 | A · derivative | 16,500 | $4.26 | $70,290 | 16,500 | No | Form 4 |
| Heiden William K | May 21, 2024 | May 23, 2024 | A · derivative | 6,500 | $0.00 | $0 | 6,500 | No | Form 4 |
| Heiden William K | May 21, 2024 | May 23, 2024 | A · derivative | 16,500 | $4.26 | $70,290 | 16,500 | No | Form 4 |
| Stump David C | May 21, 2024 | May 23, 2024 | A · derivative | 6,500 | $0.00 | $0 | 6,500 | No | Form 4 |
| Stump David C | May 21, 2024 | May 23, 2024 | A · derivative | 16,500 | $4.26 | $70,290 | 16,500 | No | Form 4 |
| Ferrante Karen Jean | May 21, 2024 | May 23, 2024 | A · derivative | 6,500 | $0.00 | $0 | 6,500 | No | Form 4 |
| Ferrante Karen Jean | May 21, 2024 | May 23, 2024 | A · derivative | 16,500 | $4.26 | $70,290 | 16,500 | No | Form 4 |
| O'Brien Federica F. | May 21, 2024 | May 23, 2024 | A · derivative | 6,500 | $0.00 | $0 | 6,500 | No | Form 4 |
| O'Brien Federica F. | May 21, 2024 | May 23, 2024 | A · derivative | 16,500 | $4.26 | $70,290 | 16,500 | No | Form 4 |
| Chhabra Meenu | May 21, 2024 | May 23, 2024 | A · derivative | 6,500 | $0.00 | $0 | 6,500 | No | Form 4 |
| Chhabra Meenu | May 21, 2024 | May 23, 2024 | A · derivative | 16,500 | $4.26 | $70,290 | 16,500 | No | Form 4 |
| Chhabra Meenu | May 21, 2024 | May 23, 2024 | A · derivative | 17,077 | $3.66 | $62,502 | 33,577 | No | Form 4 |
| Siegel Jay Philip | May 21, 2024 | May 23, 2024 | A · derivative | 6,500 | $0.00 | $0 | 6,500 | No | Form 4 |
| Siegel Jay Philip | May 21, 2024 | May 23, 2024 | A · derivative | 16,500 | $4.26 | $70,290 | 16,500 | No | Form 4 |
| Hurwitz Edward | May 20, 2024 | May 22, 2024 | M | 4,500 | $0.00 | $0 | 37,574 | No | Form 4 |
| Hurwitz Edward | May 20, 2024 | May 22, 2024 | M · derivative | 4,500 | $0.00 | $0 | not reported | No | Form 4 |
| Ferrante Karen Jean | May 20, 2024 | May 22, 2024 | M | 4,500 | $0.00 | $0 | 4,500 | No | Form 4 |
| Ferrante Karen Jean | May 20, 2024 | May 22, 2024 | M · derivative | 4,500 | $0.00 | $0 | not reported | No | Form 4 |
| Chhabra Meenu | May 20, 2024 | May 22, 2024 | M | 4,500 | $0.00 | $0 | 4,500 | No | Form 4 |
| Chhabra Meenu | May 20, 2024 | May 22, 2024 | M · derivative | 4,500 | $0.00 | $0 | not reported | No | Form 4 |
| Liu Margaret | May 20, 2024 | May 22, 2024 | M | 4,500 | $0.00 | $0 | 4,500 | No | Form 4 |
| Liu Margaret | May 20, 2024 | May 22, 2024 | M · derivative | 4,500 | $0.00 | $0 | not reported | No | Form 4 |
| O'Brien Federica F. | May 20, 2024 | May 22, 2024 | M | 4,500 | $0.00 | $0 | 4,500 | No | Form 4 |
| O'Brien Federica F. | May 20, 2024 | May 22, 2024 | M · derivative | 4,500 | $0.00 | $0 | not reported | No | Form 4 |
| Stump David C | May 20, 2024 | May 22, 2024 | M | 4,500 | $0.00 | $0 | 4,500 | No | Form 4 |
| Stump David C | May 20, 2024 | May 22, 2024 | M · derivative | 4,500 | $0.00 | $0 | not reported | No | Form 4 |
| Jackson Scott Thomas | May 20, 2024 | May 22, 2024 | M | 4,500 | $0.00 | $0 | 4,500 | No | Form 4 |
| Jackson Scott Thomas | May 20, 2024 | May 22, 2024 | M · derivative | 4,500 | $0.00 | $0 | not reported | No | Form 4 |
| Heiden William K | May 20, 2024 | May 22, 2024 | M | 4,500 | $0.00 | $0 | 4,500 | No | Form 4 |
| Heiden William K | May 20, 2024 | May 22, 2024 | M · derivative | 4,500 | $0.00 | $0 | not reported | No | Form 4 |
| Siegel Jay Philip | May 20, 2024 | May 22, 2024 | M | 4,500 | $0.00 | $0 | 4,500 | No | Form 4 |
| Siegel Jay Philip | May 20, 2024 | May 22, 2024 | M · derivative | 4,500 | $0.00 | $0 | not reported | No | Form 4 |
| Peters Jeffrey StuartSenior VP and General Counsel | Apr 4, 2024 | Apr 8, 2024 | M | 42,500 | $4.82 | $204,850 | 51,395 | Yes | Form 4 |
| Peters Jeffrey StuartSenior VP and General Counsel | Apr 4, 2024 | Apr 8, 2024 | S | 42,500 | $15.07 | Sale −$640,475 | 8,895 | Yes | Form 4 |
| Peters Jeffrey StuartSenior VP and General Counsel | Apr 4, 2024 | Apr 8, 2024 | S | 147 | $15.51 | Sale −$2,280 | 8,748 | Yes | Form 4 |
| Peters Jeffrey StuartSenior VP and General Counsel | Apr 4, 2024 | Apr 8, 2024 | S | 232 | $16.38 | Sale −$3,800 | 8,516 | Yes | Form 4 |
| Peters Jeffrey StuartSenior VP and General Counsel | Apr 4, 2024 | Apr 8, 2024 | S | 5,351 | $17.74 | Sale −$94,927 | 3,165 | Yes | Form 4 |
| Peters Jeffrey StuartSenior VP and General Counsel | Apr 4, 2024 | Apr 8, 2024 | S | 3,165 | $18.22 | Sale −$57,666 | not reported | Yes | Form 4 |
| Peters Jeffrey StuartSenior VP and General Counsel | Apr 4, 2024 | Apr 8, 2024 | M · derivative | 42,500 | $4.82 | $204,850 | 127,500 | Yes | Form 4 |
| Peters Jeffrey StuartSenior VP and General Counsel | Mar 6, 2024 | Mar 8, 2024 | M | 10,875 | $11.50 | $125,063 | 19,770 | Yes | Form 4 |
| Peters Jeffrey StuartSenior VP and General Counsel | Mar 6, 2024 | Mar 8, 2024 | M | 8,750 | $10.15 | $88,813 | 28,520 | Yes | Form 4 |
| Peters Jeffrey StuartSenior VP and General Counsel | Mar 6, 2024 | Mar 8, 2024 | S | 19,625 | $21.50 | Sale −$421,938 | 8,895 | Yes | Form 4 |
| Peters Jeffrey StuartSenior VP and General Counsel | Mar 6, 2024 | Mar 8, 2024 | M · derivative | 10,875 | $11.50 | $125,063 | not reported | Yes | Form 4 |
| Peters Jeffrey StuartSenior VP and General Counsel | Mar 6, 2024 | Mar 8, 2024 | M · derivative | 8,750 | $10.15 | $88,813 | 39,375 | Yes | Form 4 |
| Karrels JamesSVP, CFO and Secretary | Mar 4, 2024 | Mar 6, 2024 | S | 30,000 | $20.50 | Sale −$615,000 | 171,452 | Yes | Form 4 |
| Spitznagel ThomasSr VP, Technical Ops | Mar 4, 2024 | Mar 6, 2024 | M | 10,000 | $11.50 | $115,000 | 18,316 | Yes | Form 4 |
| Spitznagel ThomasSr VP, Technical Ops | Mar 4, 2024 | Mar 6, 2024 | S | 10,000 | $20.00 | Sale −$200,000 | 8,316 | Yes | Form 4 |
| Spitznagel ThomasSr VP, Technical Ops | Mar 4, 2024 | Mar 6, 2024 | M · derivative | 10,000 | $11.50 | $115,000 | 77,000 | Yes | Form 4 |
| Risser Eric BlasiusChief Operating Officer | Mar 4, 2024 | Mar 6, 2024 | M | 15,000 | $10.15 | $152,250 | 80,059 | Yes | Form 4 |
| Risser Eric BlasiusChief Operating Officer | Mar 4, 2024 | Mar 6, 2024 | S | 15,000 | $20.00 | Sale −$300,000 | 65,059 | Yes | Form 4 |
| Risser Eric BlasiusChief Operating Officer | Mar 4, 2024 | Mar 6, 2024 | S | 26,159 | $19.63 | Sale −$513,501 | 38,900 | Yes | Form 4 |
| Risser Eric BlasiusChief Operating Officer | Mar 4, 2024 | Mar 6, 2024 | M · derivative | 15,000 | $10.15 | $152,250 | 155,000 | Yes | Form 4 |
| Peters Jeffrey StuartSenior VP and General Counsel | Feb 26, 2024 | Feb 28, 2024 | S | 16,124 | $17.22 | Sale −$277,655 | 8,895 | Yes | Form 4 |
| Bonvini EzioSr VP, Research & CSO | Feb 22, 2024 | Feb 26, 2024 | M | 28,125 | $0.00 | $0 | 110,258 | No | Form 4 |
| Bonvini EzioSr VP, Research & CSO | Feb 22, 2024 | Feb 26, 2024 | F | 9,366 | $17.11 | $160,252 | 100,892 | No | Form 4 |
| Bonvini EzioSr VP, Research & CSO | Feb 22, 2024 | Feb 26, 2024 | M · derivative | 28,125 | $0.00 | $0 | not reported | No | Form 4 |
| Peters Jeffrey StuartSenior VP and General Counsel | Feb 22, 2024 | Feb 26, 2024 | M | 26,250 | $0.00 | $0 | 35,145 | No | Form 4 |
| Peters Jeffrey StuartSenior VP and General Counsel | Feb 22, 2024 | Feb 26, 2024 | F | 10,126 | $17.11 | $173,256 | 25,019 | No | Form 4 |
| Peters Jeffrey StuartSenior VP and General Counsel | Feb 22, 2024 | Feb 26, 2024 | M · derivative | 26,250 | $0.00 | $0 | not reported | No | Form 4 |
| Bonvini EzioSr VP, Research & CSO | Feb 15, 2024 | Feb 20, 2024 | M | 16,670 | $0.00 | $0 | 88,004 | No | Form 4 |
| Bonvini EzioSr VP, Research & CSO | Feb 15, 2024 | Feb 20, 2024 | F | 5,871 | $17.40 | $102,155 | 82,133 | No | Form 4 |
| Bonvini EzioSr VP, Research & CSO | Feb 15, 2024 | Feb 20, 2024 | M · derivative | 16,670 | $0.00 | $0 | 33,330 | No | Form 4 |
| Spitznagel ThomasSr VP, Technical Ops | Feb 15, 2024 | Feb 20, 2024 | M | 13,336 | $0.00 | $0 | 13,336 | No | Form 4 |
| Spitznagel ThomasSr VP, Technical Ops | Feb 15, 2024 | Feb 20, 2024 | F | 5,020 | $17.40 | $87,348 | 8,316 | No | Form 4 |
| Spitznagel ThomasSr VP, Technical Ops | Feb 15, 2024 | Feb 20, 2024 | M · derivative | 13,336 | $0.00 | $0 | 26,664 | No | Form 4 |
| Karrels JamesSVP, CFO and Secretary | Feb 15, 2024 | Feb 20, 2024 | M | 15,003 | $0.00 | $0 | 206,779 | No | Form 4 |
| Karrels JamesSVP, CFO and Secretary | Feb 15, 2024 | Feb 20, 2024 | F | 5,327 | $17.40 | $92,690 | 201,452 | No | Form 4 |
| Karrels JamesSVP, CFO and Secretary | Feb 15, 2024 | Feb 20, 2024 | M · derivative | 15,003 | $0.00 | $0 | 29,997 | No | Form 4 |
| Risser Eric BlasiusChief Operating Officer | Feb 15, 2024 | Feb 20, 2024 | M | 16,670 | $0.00 | $0 | 70,938 | No | Form 4 |
| Risser Eric BlasiusChief Operating Officer | Feb 15, 2024 | Feb 20, 2024 | F | 5,879 | $17.40 | $102,295 | 65,059 | No | Form 4 |
| Risser Eric BlasiusChief Operating Officer | Feb 15, 2024 | Feb 20, 2024 | M · derivative | 16,670 | $0.00 | $0 | 33,330 | No | Form 4 |
| Cilinski LynnVP, Controller and Treasurer | Feb 15, 2024 | Feb 20, 2024 | M | 6,668 | $0.00 | $0 | 8,591 | No | Form 4 |
| Cilinski LynnVP, Controller and Treasurer | Feb 15, 2024 | Feb 20, 2024 | F | 2,378 | $17.40 | $41,377 | 6,213 | No | Form 4 |
| Cilinski LynnVP, Controller and Treasurer | Feb 15, 2024 | Feb 20, 2024 | M · derivative | 6,668 | $0.00 | $0 | 13,332 | No | Form 4 |
| Koenig ScottPresident and CEO | Feb 15, 2024 | Feb 20, 2024 | M | 42,341 | $0.00 | $0 | 1,091,977 | No | Form 4 |
| Koenig ScottPresident and CEO | Feb 15, 2024 | Feb 20, 2024 | F | 14,349 | $17.40 | $249,673 | 1,077,628 | No | Form 4 |
| Koenig ScottPresident and CEO | Feb 15, 2024 | Feb 20, 2024 | M · derivative | 42,341 | $0.00 | $0 | 84,659 | No | Form 4 |
| Peters Jeffrey StuartSenior VP and General Counsel | Feb 15, 2024 | Feb 20, 2024 | M | 13,336 | $0.00 | $0 | 13,336 | No | Form 4 |
| Peters Jeffrey StuartSenior VP and General Counsel | Feb 15, 2024 | Feb 20, 2024 | F | 4,441 | $17.40 | $77,273 | 8,895 | No | Form 4 |
| Peters Jeffrey StuartSenior VP and General Counsel | Feb 15, 2024 | Feb 20, 2024 | M · derivative | 13,336 | $0.00 | $0 | 26,664 | No | Form 4 |
| Eck Stephen L.Chief Medical Officer | Feb 15, 2024 | Feb 20, 2024 | M | 16,670 | $0.00 | $0 | 16,670 | No | Form 4 |
| Eck Stephen L.Chief Medical Officer | Feb 15, 2024 | Feb 20, 2024 | F | 6,872 | $17.40 | $119,573 | 9,798 | No | Form 4 |
| Eck Stephen L.Chief Medical Officer | Feb 15, 2024 | Feb 20, 2024 | M · derivative | 16,670 | $0.00 | $0 | 33,330 | No | Form 4 |
| Eck Stephen L.Chief Medical Officer | Feb 8, 2024 | Feb 12, 2024 | A · derivative | 90,000 | $18.30 | $1,647,000 | 90,000 | No | Form 4 |
| Eck Stephen L.Chief Medical Officer | Feb 8, 2024 | Feb 12, 2024 | A · derivative | 33,500 | $0.00 | $0 | 33,500 | No | Form 4 |
| Karrels JamesSVP, CFO and Secretary | Feb 8, 2024 | Feb 12, 2024 | A · derivative | 80,000 | $18.30 | $1,464,000 | 80,000 | No | Form 4 |
| Karrels JamesSVP, CFO and Secretary | Feb 8, 2024 | Feb 12, 2024 | A · derivative | 30,000 | $0.00 | $0 | 30,000 | No | Form 4 |
| Koenig ScottPresident and CEO | Feb 8, 2024 | Feb 12, 2024 | A · derivative | 248,000 | $18.30 | $4,538,400 | 248,000 | No | Form 4 |
| Koenig ScottPresident and CEO | Feb 8, 2024 | Feb 12, 2024 | A · derivative | 95,000 | $0.00 | $0 | 95,000 | No | Form 4 |
| Peters Jeffrey StuartSenior VP and General Counsel | Feb 8, 2024 | Feb 12, 2024 | A · derivative | 71,000 | $18.30 | $1,299,300 | 71,000 | No | Form 4 |
| Peters Jeffrey StuartSenior VP and General Counsel | Feb 8, 2024 | Feb 12, 2024 | A · derivative | 27,000 | $0.00 | $0 | 27,000 | No | Form 4 |
| Risser Eric BlasiusChief Operating Officer | Feb 8, 2024 | Feb 12, 2024 | A · derivative | 90,000 | $18.30 | $1,647,000 | 90,000 | No | Form 4 |
| Risser Eric BlasiusChief Operating Officer | Feb 8, 2024 | Feb 12, 2024 | A · derivative | 33,500 | $0.00 | $0 | 33,500 | No | Form 4 |
| Bonvini EzioSr VP, Research & CSO | Feb 8, 2024 | Feb 12, 2024 | A · derivative | 90,000 | $18.30 | $1,647,000 | 90,000 | No | Form 4 |
| Bonvini EzioSr VP, Research & CSO | Feb 8, 2024 | Feb 12, 2024 | A · derivative | 33,500 | $0.00 | $0 | 33,500 | No | Form 4 |
| Spitznagel ThomasSr VP, Technical Ops | Feb 8, 2024 | Feb 12, 2024 | A · derivative | 71,000 | $18.30 | $1,299,300 | 71,000 | No | Form 4 |
| Spitznagel ThomasSr VP, Technical Ops | Feb 8, 2024 | Feb 12, 2024 | A · derivative | 27,000 | $0.00 | $0 | 27,000 | No | Form 4 |
| Cilinski LynnVP, Controller and Treasurer | Feb 8, 2024 | Feb 12, 2024 | A · derivative | 45,000 | $18.30 | $823,500 | 45,000 | No | Form 4 |
| Cilinski LynnVP, Controller and Treasurer | Feb 8, 2024 | Feb 12, 2024 | A · derivative | 17,000 | $0.00 | $0 | 17,000 | No | Form 4 |
| Bonvini EzioSr VP, Research & CSO | Feb 7, 2024 | Feb 7, 2024 | S | 3,334 | $18.00 | Sale −$60,012 | 71,334 | Yes | Form 4 |
| Peters Jeffrey StuartSenior VP and General Counsel | Feb 5, 2024 | Feb 7, 2024 | M | 54,376 | $11.50 | $625,324 | 54,376 | Yes | Form 4 |
| Peters Jeffrey StuartSenior VP and General Counsel | Feb 5, 2024 | Feb 7, 2024 | M | 21,875 | $10.15 | $222,031 | 76,251 | Yes | Form 4 |
| Peters Jeffrey StuartSenior VP and General Counsel | Feb 5, 2024 | Feb 7, 2024 | S | 54,376 | $16.50 | Sale −$897,204 | 21,875 | Yes | Form 4 |
| Peters Jeffrey StuartSenior VP and General Counsel | Feb 5, 2024 | Feb 7, 2024 | S | 21,875 | $16.50 | Sale −$360,938 | not reported | Yes | Form 4 |
| Peters Jeffrey StuartSenior VP and General Counsel | Feb 5, 2024 | Feb 7, 2024 | M · derivative | 54,376 | $11.50 | $625,324 | 10,875 | Yes | Form 4 |
| Peters Jeffrey StuartSenior VP and General Counsel | Feb 5, 2024 | Feb 7, 2024 | M · derivative | 21,875 | $10.15 | $222,031 | 48,125 | Yes | Form 4 |
| Bonvini EzioSr VP, Research & CSO | Feb 1, 2024 | Feb 2, 2024 | S | 13,316 | $15.00 | Sale −$199,740 | 74,668 | Yes | Form 4 |
| Bonvini EzioSr VP, Research & CSO | Jan 19, 2024 | Jan 22, 2024 | S | 13,316 | $12.00 | Sale −$159,792 | 87,984 | Yes | Form 4 |
| Bonvini EzioSr VP, Research & CSO | Dec 20, 2023 | Dec 21, 2023 | S | 18,880 | $10.08 | Sale −$190,310 | 101,300 | Yes | Form 4 |
| Bb Biotech Ag | Oct 2, 2023 | Oct 4, 2023 | P | 150,000 | $4.46 | Purchase +$669,000 | 9,929,963 | No | Form 4 |