ONCBeOne Medicines Ltd.
- Market cap
- $42.96B
- as of 2026-10-23
- Latest close
- $377.63
- as of 2026-10-23
- Sector
- Healthcare
- as of 2026-10-24
- Industry
- Biotechnology
- as of 2026-10-24
Cluster
No cluster in the last 90 days under the default rule (14d · ≥2 insiders · all roles).
Form 4 historysince 2023-11-14
Showing the latest 500 of 801 transactions.
| Insider | Traded | Filed | Type | Shares | Price | Value | Owned after | 10b5-1 plan | Filing |
|---|---|---|---|---|---|---|---|---|---|
| Wang Xiaodong | Oct 13 | Oct 15 | M | 31,027 | $36.90 | $1,144,896 | 31,027 | Yes | Form 4 |
| Wang Xiaodong | Oct 13 | Oct 15 | S | 7,167 | $349.56 | Sale −$2,505,306 | 23,860 | Yes | Form 4 |
| Wang Xiaodong | Oct 13 | Oct 15 | S | 10,361 | $350.47 | Sale −$3,631,262 | 13,499 | Yes | Form 4 |
| Wang Xiaodong | Oct 13 | Oct 15 | S | 5,681 | $351.40 | Sale −$1,996,280 | 7,818 | Yes | Form 4 |
| Wang Xiaodong | Oct 13 | Oct 15 | S | 6,558 | $352.57 | Sale −$2,312,148 | 1,260 | Yes | Form 4 |
| Wang Xiaodong | Oct 13 | Oct 15 | S | 1,260 | $353.24 | Sale −$445,078 | not reported | Yes | Form 4 |
| Wang Xiaodong | Oct 13 | Oct 15 | M · derivative | 403,351 | $2.84 | $1,145,517 | 403,364 | Yes | Form 4 |
| Lee Chan HenrySVP, General Counsel | Sep 30 | Oct 2 | S | 1,115 | $375.00 | Sale −$418,125 | not reported | Yes | Form 4 |
| Wang Xiaodong | Sep 28 | Sep 30 | M | 31,028 | $36.90 | $1,144,933 | 31,028 | Yes | Form 4 |
| Wang Xiaodong | Sep 28 | Sep 30 | S | 160 | $356.97 | Sale −$57,115 | 30,868 | Yes | Form 4 |
| Wang Xiaodong | Sep 28 | Sep 30 | S | 120 | $358.71 | Sale −$43,045 | 30,748 | Yes | Form 4 |
| Wang Xiaodong | Sep 28 | Sep 30 | S | 40 | $359.16 | Sale −$14,366 | 30,708 | Yes | Form 4 |
| Wang Xiaodong | Sep 28 | Sep 30 | S | 2,241 | $361.05 | Sale −$809,113 | 28,467 | Yes | Form 4 |
| Wang Xiaodong | Sep 28 | Sep 30 | S | 4,239 | $362.17 | Sale −$1,535,239 | 24,228 | Yes | Form 4 |
| Wang Xiaodong | Sep 28 | Sep 30 | S | 3,499 | $363.10 | Sale −$1,270,487 | 20,729 | Yes | Form 4 |
| Wang Xiaodong | Sep 28 | Sep 30 | S | 3,419 | $364.07 | Sale −$1,244,755 | 17,310 | Yes | Form 4 |
| Wang Xiaodong | Sep 28 | Sep 30 | S | 2,047 | $365.85 | Sale −$748,895 | 15,263 | Yes | Form 4 |
| Wang Xiaodong | Sep 28 | Sep 30 | S | 14,525 | $366.58 | Sale −$5,324,575 | 738 | Yes | Form 4 |
| Wang Xiaodong | Sep 28 | Sep 30 | S | 738 | $367.23 | Sale −$271,016 | not reported | Yes | Form 4 |
| Wang Xiaodong | Sep 28 | Sep 30 | M · derivative | 403,364 | $2.84 | $1,145,554 | 806,715 | Yes | Form 4 |
| Baker Bros. Advisors LP | Sep 14 | Sep 16 | M | 30,768 | $36.83 | $1,133,185 | 761,410 | No | Form 4 |
| Baker Bros. Advisors LP | Sep 14 | Sep 16 | M | 30,768 | $36.83 | $1,133,185 | 8,099,179 | No | Form 4 |
| Baker Bros. Advisors LP | Sep 14 | Sep 16 | M · derivative | 30,768 | $36.83 | $1,133,185 | not reported | No | Form 4 |
| Baker Bros. Advisors LP | Sep 14 | Sep 16 | M · derivative | 30,768 | $36.83 | $1,133,185 | not reported | No | Form 4 |
| Wang Xiaodong | Sep 8 | Sep 10 | S | 1,181 | $345.38 | Sale −$407,894 | 6,079 | Yes | Form 4 |
| Wang Xiaodong | Sep 8 | Sep 10 | S | 2,841 | $346.16 | Sale −$983,441 | 3,238 | Yes | Form 4 |
| Wang Xiaodong | Sep 8 | Sep 10 | S | 1,517 | $347.39 | Sale −$526,991 | 1,721 | Yes | Form 4 |
| Wang Xiaodong | Sep 8 | Sep 10 | S | 1,721 | $348.01 | Sale −$598,925 | not reported | Yes | Form 4 |
| Wang Xiaodong | Sep 8 | Sep 10 | M | 31,027 | $36.90 | $1,144,896 | 31,027 | Yes | Form 4 |
| Wang Xiaodong | Sep 8 | Sep 10 | S | 7,492 | $348.31 | Sale −$2,609,539 | 23,535 | Yes | Form 4 |
| Wang Xiaodong | Sep 8 | Sep 10 | S | 10,688 | $349.28 | Sale −$3,733,105 | 12,847 | Yes | Form 4 |
| Wang Xiaodong | Sep 8 | Sep 10 | S | 6,569 | $350.27 | Sale −$2,300,924 | 6,278 | Yes | Form 4 |
| Wang Xiaodong | Sep 8 | Sep 10 | S | 6,278 | $351.25 | Sale −$2,205,148 | not reported | Yes | Form 4 |
| Wang Xiaodong | Sep 8 | Sep 10 | M · derivative | 403,351 | $2.84 | $1,145,517 | 1,210,079 | Yes | Form 4 |
| Ball Titus B.Principal Accounting Officer | Sep 1 | Sep 3 | S | 132 | $355.86 | Sale −$46,974 | not reported | No | Form 4 |
| Wu XiaobinPresident and COO | Aug 25 | Aug 27 | S | 280 | $380.00 | Sale −$106,400 | not reported | Yes | Form 4 |
| Lee Chan HenrySVP, General Counsel | Aug 11 | Aug 13 | M | 812 | $194.47 | $157,910 | 812 | Yes | Form 4 |
| Lee Chan HenrySVP, General Counsel | Aug 11 | Aug 13 | M | 1,058 | $213.32 | $225,693 | 1,870 | Yes | Form 4 |
| Lee Chan HenrySVP, General Counsel | Aug 11 | Aug 13 | M | 796 | $159.03 | $126,588 | 2,666 | Yes | Form 4 |
| Lee Chan HenrySVP, General Counsel | Aug 11 | Aug 13 | S | 2,666 | $360.00 | Sale −$959,760 | not reported | Yes | Form 4 |
| Lee Chan HenrySVP, General Counsel | Aug 11 | Aug 13 | M · derivative | 10,556 | $14.96 | $157,918 | not reported | Yes | Form 4 |
| Lee Chan HenrySVP, General Counsel | Aug 11 | Aug 13 | M · derivative | 13,754 | $16.41 | $225,703 | 57,369 | Yes | Form 4 |
| Lee Chan HenrySVP, General Counsel | Aug 11 | Aug 13 | M · derivative | 10,348 | $12.23 | $126,556 | 88,582 | Yes | Form 4 |
| Oyler JohnChief Executive Officer | Aug 12 | Aug 12 | S | 1,980 | $354.71 | Sale −$702,326 | 52,912 | Yes | Form 4 |
| Oyler JohnChief Executive Officer | Aug 12 | Aug 12 | S | 2,515 | $356.43 | Sale −$896,421 | 50,397 | Yes | Form 4 |
| Oyler JohnChief Executive Officer | Aug 12 | Aug 12 | S | 15,396 | $357.63 | Sale −$5,506,071 | 35,001 | Yes | Form 4 |
| Oyler JohnChief Executive Officer | Aug 12 | Aug 12 | S | 20,899 | $358.41 | Sale −$7,490,411 | 14,102 | Yes | Form 4 |
| Oyler JohnChief Executive Officer | Aug 12 | Aug 12 | S | 14,102 | $359.12 | Sale −$5,064,310 | not reported | Yes | Form 4 |
| Oyler JohnChief Executive Officer | Aug 11 | Aug 12 | S | 13,695 | $359.32 | Sale −$4,920,887 | 112,104 | Yes | Form 4 |
| Oyler JohnChief Executive Officer | Aug 11 | Aug 12 | S | 8,081 | $360.33 | Sale −$2,911,827 | 104,023 | Yes | Form 4 |
| Oyler JohnChief Executive Officer | Aug 11 | Aug 12 | S | 14,569 | $361.47 | Sale −$5,266,256 | 89,454 | Yes | Form 4 |
| Oyler JohnChief Executive Officer | Aug 11 | Aug 12 | S | 11,568 | $362.34 | Sale −$4,191,549 | 77,886 | Yes | Form 4 |
| Oyler JohnChief Executive Officer | Aug 11 | Aug 12 | S | 13,403 | $363.45 | Sale −$4,871,320 | 64,483 | Yes | Form 4 |
| Oyler JohnChief Executive Officer | Aug 11 | Aug 12 | S | 5,211 | $364.31 | Sale −$1,898,419 | 59,272 | Yes | Form 4 |
| Oyler JohnChief Executive Officer | Aug 11 | Aug 12 | S | 3,176 | $365.26 | Sale −$1,160,066 | 56,096 | Yes | Form 4 |
| Oyler JohnChief Executive Officer | Aug 11 | Aug 12 | S | 1,200 | $366.31 | Sale −$439,572 | 54,896 | Yes | Form 4 |
| Oyler JohnChief Executive Officer | Aug 11 | Aug 12 | S | 4 | $367.00 | Sale −$1,468 | 54,892 | Yes | Form 4 |
| Oyler JohnChief Executive Officer | Aug 10 | Aug 12 | S | 67 | $350.00 | Sale −$23,450 | 240,743 | Yes | Form 4 |
| Oyler JohnChief Executive Officer | Aug 10 | Aug 12 | S | 2,813 | $351.80 | Sale −$989,613 | 237,930 | Yes | Form 4 |
| Oyler JohnChief Executive Officer | Aug 10 | Aug 12 | S | 3,673 | $353.32 | Sale −$1,297,744 | 234,257 | Yes | Form 4 |
| Oyler JohnChief Executive Officer | Aug 10 | Aug 12 | S | 6,717 | $354.78 | Sale −$2,383,057 | 227,540 | Yes | Form 4 |
| Oyler JohnChief Executive Officer | Aug 10 | Aug 12 | S | 3,476 | $355.66 | Sale −$1,236,274 | 224,064 | Yes | Form 4 |
| Oyler JohnChief Executive Officer | Aug 10 | Aug 12 | S | 12,418 | $356.62 | Sale −$4,428,507 | 211,646 | Yes | Form 4 |
| Oyler JohnChief Executive Officer | Aug 10 | Aug 12 | S | 15,869 | $357.67 | Sale −$5,675,865 | 195,777 | Yes | Form 4 |
| Oyler JohnChief Executive Officer | Aug 10 | Aug 12 | S | 45,044 | $358.70 | Sale −$16,157,283 | 150,733 | Yes | Form 4 |
| Oyler JohnChief Executive Officer | Aug 10 | Aug 12 | S | 21,254 | $359.50 | Sale −$7,640,813 | 129,479 | Yes | Form 4 |
| Oyler JohnChief Executive Officer | Aug 10 | Aug 12 | S | 3,680 | $360.63 | Sale −$1,327,118 | 125,799 | Yes | Form 4 |
| Rosenberg AaronChief Financial Officer | Aug 3 | Aug 5 | S | 1,157 | $312.72 | Sale −$361,817 | not reported | No | Form 4 |
| Lee Chan HenrySVP, General Counsel | Jul 30 | Aug 3 | S | 1,044 | $323.69 | Sale −$337,932 | not reported | No | Form 4 |
| Lee Chan HenrySVP, General Counsel | Jul 22 | Jul 24 | M | 514 | $194.47 | $99,958 | 514 | Yes | Form 4 |
| Lee Chan HenrySVP, General Counsel | Jul 22 | Jul 24 | M | 665 | $213.32 | $141,858 | 1,179 | Yes | Form 4 |
| Lee Chan HenrySVP, General Counsel | Jul 22 | Jul 24 | M | 490 | $159.03 | $77,925 | 1,669 | Yes | Form 4 |
| Lee Chan HenrySVP, General Counsel | Jul 22 | Jul 24 | S | 1,669 | $325.00 | Sale −$542,425 | not reported | Yes | Form 4 |
| Lee Chan HenrySVP, General Counsel | Jul 22 | Jul 24 | M · derivative | 6,682 | $14.96 | $99,963 | 10,556 | Yes | Form 4 |
| Lee Chan HenrySVP, General Counsel | Jul 22 | Jul 24 | M · derivative | 8,645 | $16.41 | $141,864 | 71,123 | Yes | Form 4 |
| Lee Chan HenrySVP, General Counsel | Jul 22 | Jul 24 | M · derivative | 6,370 | $12.23 | $77,905 | 98,930 | Yes | Form 4 |
| Oyler JohnChief Executive Officer | Jul 21 | Jul 22 | S | 15,379 | $316.26 | Sale −$4,863,763 | 46,018 | Yes | Form 4 |
| Oyler JohnChief Executive Officer | Jul 21 | Jul 22 | S | 20,029 | $316.91 | Sale −$6,347,390 | 25,989 | Yes | Form 4 |
| Oyler JohnChief Executive Officer | Jul 21 | Jul 22 | S | 7,842 | $318.41 | Sale −$2,496,971 | 18,147 | Yes | Form 4 |
| Oyler JohnChief Executive Officer | Jul 21 | Jul 22 | S | 15,807 | $319.29 | Sale −$5,047,017 | 2,340 | Yes | Form 4 |
| Oyler JohnChief Executive Officer | Jul 21 | Jul 22 | S | 2,340 | $320.06 | Sale −$748,940 | not reported | Yes | Form 4 |
| Oyler JohnChief Executive Officer | Jul 20 | Jul 22 | S | 5,146 | $310.08 | Sale −$1,595,672 | 9,180 | Yes | Form 4 |
| Oyler JohnChief Executive Officer | Jul 20 | Jul 22 | S | 6,273 | $310.75 | Sale −$1,949,335 | 2,907 | Yes | Form 4 |
| Oyler JohnChief Executive Officer | Jul 20 | Jul 22 | S | 2,907 | $311.80 | Sale −$906,403 | not reported | Yes | Form 4 |
| Oyler JohnChief Executive Officer | Jul 20 | Jul 22 | M | 33,990 | $119.96 | $4,077,440 | 33,990 | Yes | Form 4 |
| Oyler JohnChief Executive Officer | Jul 20 | Jul 22 | S | 15,499 | $312.29 | Sale −$4,840,183 | 18,491 | Yes | Form 4 |
| Oyler JohnChief Executive Officer | Jul 20 | Jul 22 | S | 14,326 | $312.96 | Sale −$4,483,465 | 4,165 | Yes | Form 4 |
| Oyler JohnChief Executive Officer | Jul 20 | Jul 22 | S | 1,850 | $313.91 | Sale −$580,734 | 2,315 | Yes | Form 4 |
| Oyler JohnChief Executive Officer | Jul 20 | Jul 22 | S | 1,512 | $315.26 | Sale −$476,673 | 803 | Yes | Form 4 |
| Oyler JohnChief Executive Officer | Jul 20 | Jul 22 | S | 523 | $316.14 | Sale −$165,341 | 280 | Yes | Form 4 |
| Oyler JohnChief Executive Officer | Jul 20 | Jul 22 | S | 280 | $318.30 | Sale −$89,124 | not reported | Yes | Form 4 |
| Oyler JohnChief Executive Officer | Jul 20 | Jul 22 | M · derivative | 441,870 | $9.23 | $4,078,460 | not reported | Yes | Form 4 |
| Oyler JohnChief Executive Officer | Jul 17 | Jul 17 | M | 64,628 | $119.96 | $7,752,775 | 64,628 | Yes | Form 4 |
| Oyler JohnChief Executive Officer | Jul 17 | Jul 17 | S | 1,440 | $305.20 | Sale −$439,488 | 63,188 | Yes | Form 4 |
| Oyler JohnChief Executive Officer | Jul 17 | Jul 17 | S | 597 | $306.96 | Sale −$183,255 | 62,591 | Yes | Form 4 |
| Oyler JohnChief Executive Officer | Jul 17 | Jul 17 | S | 680 | $309.05 | Sale −$210,154 | 61,911 | Yes | Form 4 |
| Oyler JohnChief Executive Officer | Jul 17 | Jul 17 | S | 4,833 | $310.37 | Sale −$1,500,018 | 57,078 | Yes | Form 4 |
| Oyler JohnChief Executive Officer | Jul 17 | Jul 17 | S | 5,543 | $311.42 | Sale −$1,726,201 | 51,535 | Yes | Form 4 |
| Oyler JohnChief Executive Officer | Jul 17 | Jul 17 | S | 35,829 | $312.17 | Sale −$11,184,739 | 15,706 | Yes | Form 4 |
| Oyler JohnChief Executive Officer | Jul 17 | Jul 17 | S | 14,915 | $313.19 | Sale −$4,671,229 | 791 | Yes | Form 4 |
| Oyler JohnChief Executive Officer | Jul 17 | Jul 17 | S | 740 | $314.32 | Sale −$232,597 | 51 | Yes | Form 4 |
| Oyler JohnChief Executive Officer | Jul 17 | Jul 17 | S | 51 | $315.06 | Sale −$16,068 | not reported | Yes | Form 4 |
| Oyler JohnChief Executive Officer | Jul 17 | Jul 17 | M · derivative | 840,164 | $9.23 | $7,754,714 | 441,870 | Yes | Form 4 |
| Oyler JohnChief Executive Officer | Jul 16 | Jul 17 | M | 96,501 | $160.40 | $15,478,760 | 96,501 | Yes | Form 4 |
| Oyler JohnChief Executive Officer | Jul 16 | Jul 17 | M | 70,096 | $119.96 | $8,408,716 | 166,597 | Yes | Form 4 |
| Oyler JohnChief Executive Officer | Jul 16 | Jul 17 | S | 233 | $311.98 | Sale −$72,691 | 166,364 | Yes | Form 4 |
| Oyler JohnChief Executive Officer | Jul 16 | Jul 17 | S | 4,881 | $314.08 | Sale −$1,533,024 | 161,483 | Yes | Form 4 |
| Oyler JohnChief Executive Officer | Jul 16 | Jul 17 | S | 9,516 | $314.73 | Sale −$2,994,971 | 151,967 | Yes | Form 4 |
| Oyler JohnChief Executive Officer | Jul 16 | Jul 17 | S | 19,752 | $316.00 | Sale −$6,241,632 | 132,215 | Yes | Form 4 |
| Oyler JohnChief Executive Officer | Jul 16 | Jul 17 | S | 32,224 | $316.82 | Sale −$10,209,208 | 99,991 | Yes | Form 4 |
| Oyler JohnChief Executive Officer | Jul 16 | Jul 17 | S | 42,798 | $317.79 | Sale −$13,600,776 | 57,193 | Yes | Form 4 |
| Oyler JohnChief Executive Officer | Jul 16 | Jul 17 | S | 6,402 | $318.55 | Sale −$2,039,357 | 50,791 | Yes | Form 4 |
| Oyler JohnChief Executive Officer | Jul 16 | Jul 17 | S | 15,097 | $319.99 | Sale −$4,830,889 | 35,694 | Yes | Form 4 |
| Oyler JohnChief Executive Officer | Jul 16 | Jul 17 | S | 20,505 | $321.00 | Sale −$6,582,105 | 15,189 | Yes | Form 4 |
| Oyler JohnChief Executive Officer | Jul 16 | Jul 17 | S | 13,109 | $321.61 | Sale −$4,215,985 | 2,080 | Yes | Form 4 |
| Oyler JohnChief Executive Officer | Jul 16 | Jul 17 | S | 1,560 | $322.71 | Sale −$503,428 | 520 | Yes | Form 4 |
| Oyler JohnChief Executive Officer | Jul 16 | Jul 17 | S | 520 | $323.59 | Sale −$168,267 | not reported | Yes | Form 4 |
| Oyler JohnChief Executive Officer | Jul 16 | Jul 17 | M · derivative | 1,254,513 | $12.34 | $15,480,690 | not reported | Yes | Form 4 |
| Oyler JohnChief Executive Officer | Jul 16 | Jul 17 | M · derivative | 911,248 | $9.23 | $8,410,819 | 1,282,034 | Yes | Form 4 |
| Oyler JohnChief Executive Officer | Jul 15 | Jul 17 | M | 35,605 | $100.04 | $3,561,924 | 35,605 | Yes | Form 4 |
| Oyler JohnChief Executive Officer | Jul 15 | Jul 17 | M | 76,677 | $169.58 | $13,002,886 | 112,282 | Yes | Form 4 |
| Oyler JohnChief Executive Officer | Jul 15 | Jul 17 | M | 4,275 | $160.40 | $685,710 | 116,557 | Yes | Form 4 |
| Oyler JohnChief Executive Officer | Jul 15 | Jul 17 | S | 6,067 | $310.02 | Sale −$1,880,891 | 110,490 | Yes | Form 4 |
| Oyler JohnChief Executive Officer | Jul 15 | Jul 17 | S | 41,336 | $310.92 | Sale −$12,852,189 | 69,154 | Yes | Form 4 |
| Oyler JohnChief Executive Officer | Jul 15 | Jul 17 | S | 12,857 | $311.71 | Sale −$4,007,655 | 56,297 | Yes | Form 4 |
| Oyler JohnChief Executive Officer | Jul 15 | Jul 17 | S | 48,657 | $312.86 | Sale −$15,222,829 | 7,640 | Yes | Form 4 |
| Oyler JohnChief Executive Officer | Jul 15 | Jul 17 | S | 7,640 | $313.58 | Sale −$2,395,751 | not reported | Yes | Form 4 |
| Oyler JohnChief Executive Officer | Jul 15 | Jul 17 | M · derivative | 462,865 | $7.70 | $3,564,061 | 1 | Yes | Form 4 |
| Oyler JohnChief Executive Officer | Jul 15 | Jul 17 | M · derivative | 996,801 | $13.05 | $13,008,253 | 9 | Yes | Form 4 |
| Oyler JohnChief Executive Officer | Jul 15 | Jul 17 | M · derivative | 55,575 | $12.34 | $685,796 | 1,254,513 | Yes | Form 4 |
| Oyler JohnChief Executive Officer | Jul 14 | Jul 14 | S | 4,139 | $303.07 | Sale −$1,254,407 | 8,122 | Yes | Form 4 |
| Oyler JohnChief Executive Officer | Jul 14 | Jul 14 | S | 8,122 | $303.93 | Sale −$2,468,519 | not reported | Yes | Form 4 |
| Oyler JohnChief Executive Officer | Jul 14 | Jul 14 | M | 97,282 | $36.90 | $3,589,706 | 97,282 | Yes | Form 4 |
| Oyler JohnChief Executive Officer | Jul 14 | Jul 14 | M | 36,318 | $100.04 | $3,633,253 | 133,600 | Yes | Form 4 |
| Oyler JohnChief Executive Officer | Jul 14 | Jul 14 | S | 39,090 | $305.02 | Sale −$11,923,232 | 94,510 | Yes | Form 4 |
| Oyler JohnChief Executive Officer | Jul 14 | Jul 14 | S | 45,895 | $306.21 | Sale −$14,053,508 | 48,615 | Yes | Form 4 |
| Oyler JohnChief Executive Officer | Jul 14 | Jul 14 | S | 40,781 | $306.93 | Sale −$12,516,912 | 7,834 | Yes | Form 4 |
| Oyler JohnChief Executive Officer | Jul 14 | Jul 14 | S | 7,834 | $307.57 | Sale −$2,409,503 | not reported | Yes | Form 4 |
| Oyler JohnChief Executive Officer | Jul 14 | Jul 14 | M · derivative | 1,264,666 | $2.84 | $3,591,651 | not reported | Yes | Form 4 |
| Oyler JohnChief Executive Officer | Jul 14 | Jul 14 | M · derivative | 472,134 | $7.70 | $3,635,432 | 462,866 | Yes | Form 4 |
| Oyler JohnChief Executive Officer | Jul 13 | Jul 14 | M | 48,520 | $36.90 | $1,790,388 | 48,520 | Yes | Form 4 |
| Oyler JohnChief Executive Officer | Jul 13 | Jul 14 | S | 798 | $301.94 | Sale −$240,948 | 47,722 | Yes | Form 4 |
| Oyler JohnChief Executive Officer | Jul 13 | Jul 14 | S | 4,584 | $302.79 | Sale −$1,387,989 | 43,138 | Yes | Form 4 |
| Oyler JohnChief Executive Officer | Jul 13 | Jul 14 | S | 26,294 | $303.83 | Sale −$7,988,906 | 16,844 | Yes | Form 4 |
| Oyler JohnChief Executive Officer | Jul 13 | Jul 14 | S | 8,438 | $304.68 | Sale −$2,570,890 | 8,406 | Yes | Form 4 |
| Oyler JohnChief Executive Officer | Jul 13 | Jul 14 | S | 846 | $305.57 | Sale −$258,512 | 7,560 | Yes | Form 4 |
| Oyler JohnChief Executive Officer | Jul 13 | Jul 14 | S | 7,240 | $306.82 | Sale −$2,221,377 | 320 | Yes | Form 4 |
| Oyler JohnChief Executive Officer | Jul 13 | Jul 14 | S | 320 | $307.41 | Sale −$98,371 | not reported | Yes | Form 4 |
| Oyler JohnChief Executive Officer | Jul 13 | Jul 14 | M · derivative | 630,760 | $2.84 | $1,791,358 | 1,264,666 | Yes | Form 4 |
| Oyler JohnChief Executive Officer | Jul 10 | Jul 14 | M | 11,698 | $36.90 | $431,656 | 11,698 | Yes | Form 4 |
| Oyler JohnChief Executive Officer | Jul 10 | Jul 14 | S | 1,493 | $296.07 | Sale −$442,033 | 10,205 | Yes | Form 4 |
| Oyler JohnChief Executive Officer | Jul 10 | Jul 14 | S | 1,314 | $297.23 | Sale −$390,560 | 8,891 | Yes | Form 4 |
| Oyler JohnChief Executive Officer | Jul 10 | Jul 14 | S | 3,074 | $298.35 | Sale −$917,128 | 5,817 | Yes | Form 4 |
| Oyler JohnChief Executive Officer | Jul 10 | Jul 14 | S | 5,143 | $298.94 | Sale −$1,537,448 | 674 | Yes | Form 4 |
| Oyler JohnChief Executive Officer | Jul 10 | Jul 14 | S | 370 | $300.12 | Sale −$111,044 | 304 | Yes | Form 4 |
| Oyler JohnChief Executive Officer | Jul 10 | Jul 14 | S | 150 | $301.18 | Sale −$45,177 | 154 | Yes | Form 4 |
| Oyler JohnChief Executive Officer | Jul 10 | Jul 14 | S | 136 | $302.19 | Sale −$41,098 | 18 | Yes | Form 4 |
| Oyler JohnChief Executive Officer | Jul 10 | Jul 14 | S | 18 | $303.03 | Sale −$5,455 | not reported | Yes | Form 4 |
| Oyler JohnChief Executive Officer | Jul 10 | Jul 14 | M · derivative | 152,074 | $2.84 | $431,890 | 1,895,426 | Yes | Form 4 |
| Lee Chan HenrySVP, General Counsel | Jul 8 | Jul 10 | M | 202 | $194.47 | $39,283 | 202 | Yes | Form 4 |
| Lee Chan HenrySVP, General Counsel | Jul 8 | Jul 10 | M | 266 | $213.32 | $56,743 | 468 | Yes | Form 4 |
| Lee Chan HenrySVP, General Counsel | Jul 8 | Jul 10 | M | 196 | $159.03 | $31,170 | 664 | Yes | Form 4 |
| Lee Chan HenrySVP, General Counsel | Jul 8 | Jul 10 | S | 664 | $302.46 | Sale −$200,833 | not reported | Yes | Form 4 |
| Lee Chan HenrySVP, General Counsel | Jul 8 | Jul 10 | M · derivative | 2,626 | $14.96 | $39,285 | 17,238 | Yes | Form 4 |
| Lee Chan HenrySVP, General Counsel | Jul 8 | Jul 10 | M · derivative | 3,458 | $16.41 | $56,746 | 79,768 | Yes | Form 4 |
| Lee Chan HenrySVP, General Counsel | Jul 8 | Jul 10 | M · derivative | 2,548 | $12.23 | $31,162 | 105,300 | Yes | Form 4 |
| Oyler JohnChief Executive Officer | Jun 23 | Jun 25 | S | 1,800 | $273.30 | Sale −$491,940 | 1,610 | No | Form 4 |
| Oyler JohnChief Executive Officer | Jun 23 | Jun 25 | S | 1,290 | $274.12 | Sale −$353,615 | 320 | No | Form 4 |
| Oyler JohnChief Executive Officer | Jun 23 | Jun 25 | S | 320 | $275.10 | Sale −$88,032 | not reported | No | Form 4 |
| Wu XiaobinPresident and COO | Jun 23 | Jun 25 | S | 1,292 | $276.26 | Sale −$356,928 | not reported | No | Form 4 |
| Wang LaiPresident, Global Head of R&D | Jun 23 | Jun 25 | S | 1,068 | $276.74 | Sale −$295,558 | not reported | No | Form 4 |
| Oyler JohnChief Executive Officer | Jun 16 | Jun 18 | S | 1,650 | $264.87 | Sale −$437,036 | 2,043 | No | Form 4 |
| Oyler JohnChief Executive Officer | Jun 16 | Jun 18 | S | 1,710 | $265.99 | Sale −$454,843 | 333 | No | Form 4 |
| Oyler JohnChief Executive Officer | Jun 16 | Jun 18 | S | 333 | $266.69 | Sale −$88,808 | not reported | No | Form 4 |
| Wu XiaobinPresident and COO | Jun 16 | Jun 18 | S | 1,357 | $266.76 | Sale −$361,993 | not reported | No | Form 4 |
| Wang LaiPresident, Global Head of R&D | Jun 16 | Jun 18 | S | 1,169 | $265.39 | Sale −$310,241 | not reported | No | Form 4 |
| Lee Chan HenrySVP, General Counsel | Jun 16 | Jun 18 | S | 590 | $265.98 | Sale −$156,928 | not reported | No | Form 4 |
| Oyler JohnChief Executive Officer | Jun 11 | Jun 15 | A | 177,931 | $0.00 | $0 | 5,697,649 | No | Form 4 |
| Oyler JohnChief Executive Officer | Jun 11 | Jun 15 | S | 741 | $256.23 | Sale −$189,866 | 1,208 | No | Form 4 |
| Oyler JohnChief Executive Officer | Jun 11 | Jun 15 | S | 859 | $257.59 | Sale −$221,270 | 349 | No | Form 4 |
| Oyler JohnChief Executive Officer | Jun 11 | Jun 15 | S | 200 | $258.28 | Sale −$51,656 | 149 | No | Form 4 |
| Oyler JohnChief Executive Officer | Jun 11 | Jun 15 | S | 149 | $258.81 | Sale −$38,563 | not reported | No | Form 4 |
| Oyler JohnChief Executive Officer | Jun 11 | Jun 15 | A · derivative | 344,669 | $20.81 | $7,172,562 | 344,669 | No | Form 4 |
| Baker Brothers Life Sciences LP | Jun 11 | Jun 15 | A | 18,980 | $0.00 | $0 | 161,546 | No | Form 4 |
| Baker Brothers Life Sciences LP | Jun 11 | Jun 15 | A | 18,980 | $0.00 | $0 | 161,550 | No | Form 4 |
| Hooper Anthony C | Jun 11 | Jun 15 | A | 18,980 | $0.00 | $0 | 83,720 | No | Form 4 |
| Sharp Shalini | Jun 11 | Jun 15 | A | 18,980 | $0.00 | $0 | 38,116 | No | Form 4 |
| Brandicourt Olivier | Jun 11 | Jun 15 | A | 18,980 | $0.00 | $0 | 46,306 | No | Form 4 |
| Wang Xiaodong | Jun 11 | Jun 15 | A | 99,892 | $0.00 | $0 | 4,682,493 | No | Form 4 |
| Wang Xiaodong | Jun 11 | Jun 15 | A · derivative | 193,492 | $20.81 | $4,026,569 | 193,492 | No | Form 4 |
| Ball Titus B.Principal Accounting Officer | Jun 11 | Jun 15 | A | 31,213 | $0.00 | $0 | 99,645 | No | Form 4 |
| Ball Titus B.Principal Accounting Officer | Jun 11 | Jun 15 | S | 49 | $256.39 | Sale −$12,563 | 120 | No | Form 4 |
| Ball Titus B.Principal Accounting Officer | Jun 11 | Jun 15 | S | 120 | $257.53 | Sale −$30,904 | not reported | No | Form 4 |
| Wu XiaobinPresident and COO | Jun 11 | Jun 15 | A | 118,625 | $0.00 | $0 | 1,308,161 | No | Form 4 |
| Wu XiaobinPresident and COO | Jun 11 | Jun 15 | S | 626 | $261.20 | Sale −$163,511 | not reported | No | Form 4 |
| Wu XiaobinPresident and COO | Jun 11 | Jun 15 | A · derivative | 229,775 | $20.81 | $4,781,618 | 229,775 | No | Form 4 |
| Wang LaiPresident, Global Head of R&D | Jun 11 | Jun 15 | A | 118,625 | $0.00 | $0 | 1,710,085 | No | Form 4 |
| Wang LaiPresident, Global Head of R&D | Jun 11 | Jun 15 | S | 756 | $261.00 | Sale −$197,316 | not reported | No | Form 4 |
| Wang LaiPresident, Global Head of R&D | Jun 11 | Jun 15 | A · derivative | 229,775 | $20.81 | $4,781,618 | 229,775 | No | Form 4 |
| Riva Alessandro | Jun 11 | Jun 15 | A | 18,980 | $0.00 | $0 | 73,164 | No | Form 4 |
| Dugan Margaret | Jun 11 | Jun 15 | A | 18,980 | $0.00 | $0 | 73,164 | No | Form 4 |
| Lee Chan HenrySVP, General Counsel | Jun 11 | Jun 15 | A | 45,071 | $0.00 | $0 | 346,554 | No | Form 4 |
| Lee Chan HenrySVP, General Counsel | Jun 11 | Jun 15 | S | 428 | $257.64 | Sale −$110,270 | not reported | No | Form 4 |
| Lee Chan HenrySVP, General Counsel | Jun 11 | Jun 15 | A · derivative | 87,308 | $20.81 | $1,816,879 | 87,308 | No | Form 4 |
| Rosenberg AaronChief Financial Officer | Jun 11 | Jun 15 | A | 71,175 | $0.00 | $0 | 397,891 | No | Form 4 |
| Rosenberg AaronChief Financial Officer | Jun 11 | Jun 15 | S | 631 | $257.74 | Sale −$162,634 | not reported | No | Form 4 |
| Rosenberg AaronChief Financial Officer | Jun 11 | Jun 15 | A · derivative | 137,865 | $20.81 | $2,868,971 | 137,865 | No | Form 4 |
| Sawyers Charles Lazelle | Jun 11 | Jun 15 | A | 18,980 | $0.00 | $0 | 18,984 | No | Form 4 |
| Mooney Elizabeth Fisher | Jun 11 | Jun 15 | A | 18,980 | $0.00 | $0 | 18,980 | No | Form 4 |
| Oyler JohnChief Executive Officer | Jun 8 | Jun 10 | S | 3,820 | $270.38 | Sale −$1,032,852 | 1,120 | No | Form 4 |
| Oyler JohnChief Executive Officer | Jun 8 | Jun 10 | S | 1,120 | $271.14 | Sale −$303,677 | not reported | No | Form 4 |
| Ball Titus B.Principal Accounting Officer | Jun 8 | Jun 10 | S | 100 | $271.06 | Sale −$27,106 | 36 | No | Form 4 |
| Ball Titus B.Principal Accounting Officer | Jun 8 | Jun 10 | S | 36 | $272.08 | Sale −$9,795 | not reported | No | Form 4 |
| Wu XiaobinPresident and COO | Jun 8 | Jun 10 | S | 1,444 | $269.33 | Sale −$388,913 | 40 | No | Form 4 |
| Wu XiaobinPresident and COO | Jun 8 | Jun 10 | S | 40 | $270.55 | Sale −$10,822 | not reported | No | Form 4 |
| Wang LaiPresident, Global Head of R&D | Jun 8 | Jun 10 | S | 1,327 | $269.34 | Sale −$357,414 | 40 | No | Form 4 |
| Wang LaiPresident, Global Head of R&D | Jun 8 | Jun 10 | S | 40 | $270.73 | Sale −$10,829 | not reported | No | Form 4 |
| Lee Chan HenrySVP, General Counsel | Jun 8 | Jun 10 | S | 711 | $270.24 | Sale −$192,141 | 160 | No | Form 4 |
| Lee Chan HenrySVP, General Counsel | Jun 8 | Jun 10 | S | 160 | $271.26 | Sale −$43,402 | not reported | No | Form 4 |
| Yi Qingqing | Jun 1 | Jun 3 | S | 235 | $279.13 | Sale −$65,596 | not reported | No | Form 4 |
| Baker Bros. Advisors LP | May 22 | May 27 | S | 2,743 | $23.85 | Sale −$65,421 | 145,322 | No | Form 4 |
| Baker Bros. Advisors LP | May 22 | May 27 | S | 2,743 | $23.85 | Sale −$65,421 | 145,326 | No | Form 4 |
| Baker Bros. Advisors LP | May 22 | May 27 | S | 2,756 | $23.79 | Sale −$65,565 | 142,566 | No | Form 4 |
| Baker Bros. Advisors LP | May 22 | May 27 | S | 2,756 | $23.79 | Sale −$65,565 | 142,570 | No | Form 4 |
| Sanders Corazon (Corsee) D. | May 22 | May 27 | S | 212 | $309.59 | Sale −$65,633 | not reported | No | Form 4 |
| Riva Alessandro | May 22 | May 27 | S | 212 | $309.51 | Sale −$65,616 | not reported | No | Form 4 |
| Dugan Margaret | May 22 | May 27 | S | 212 | $309.60 | Sale −$65,635 | not reported | No | Form 4 |
| Lee Chan HenrySVP, General Counsel | May 13 | May 15 | M | 101 | $194.47 | $19,641 | 101 | Yes | Form 4 |
| Lee Chan HenrySVP, General Counsel | May 13 | May 15 | M | 133 | $213.32 | $28,372 | 234 | Yes | Form 4 |
| Lee Chan HenrySVP, General Counsel | May 13 | May 15 | M | 98 | $159.03 | $15,585 | 332 | Yes | Form 4 |
| Lee Chan HenrySVP, General Counsel | May 13 | May 15 | S | 332 | $310.72 | Sale −$103,159 | not reported | Yes | Form 4 |
| Lee Chan HenrySVP, General Counsel | May 13 | May 15 | M · derivative | 1,313 | $14.96 | $19,642 | 19,864 | Yes | Form 4 |
| Lee Chan HenrySVP, General Counsel | May 13 | May 15 | M · derivative | 1,729 | $16.41 | $28,373 | 83,226 | Yes | Form 4 |
| Lee Chan HenrySVP, General Counsel | May 13 | May 15 | M · derivative | 1,274 | $12.23 | $15,581 | 107,848 | Yes | Form 4 |
| Lee Chan HenrySVP, General Counsel | Apr 8 | Apr 10 | M | 101 | $194.47 | $19,641 | 101 | Yes | Form 4 |
| Lee Chan HenrySVP, General Counsel | Apr 8 | Apr 10 | M | 133 | $213.32 | $28,372 | 234 | Yes | Form 4 |
| Lee Chan HenrySVP, General Counsel | Apr 8 | Apr 10 | M | 98 | $159.03 | $15,585 | 332 | Yes | Form 4 |
| Lee Chan HenrySVP, General Counsel | Apr 8 | Apr 10 | S | 332 | $311.59 | Sale −$103,448 | not reported | Yes | Form 4 |
| Lee Chan HenrySVP, General Counsel | Apr 8 | Apr 10 | M · derivative | 1,313 | $14.96 | $19,642 | 21,177 | Yes | Form 4 |
| Lee Chan HenrySVP, General Counsel | Apr 8 | Apr 10 | M · derivative | 1,729 | $16.41 | $28,373 | 84,955 | Yes | Form 4 |
| Lee Chan HenrySVP, General Counsel | Apr 8 | Apr 10 | M · derivative | 1,274 | $12.23 | $15,581 | 109,122 | Yes | Form 4 |
| Lee Chan HenrySVP, General Counsel | Mar 11 | Mar 13 | M | 110 | $194.47 | $21,392 | 110 | Yes | Form 4 |
| Lee Chan HenrySVP, General Counsel | Mar 11 | Mar 13 | M | 133 | $213.32 | $28,372 | 243 | Yes | Form 4 |
| Lee Chan HenrySVP, General Counsel | Mar 11 | Mar 13 | M | 98 | $159.03 | $15,585 | 341 | Yes | Form 4 |
| Lee Chan HenrySVP, General Counsel | Mar 11 | Mar 13 | S | 341 | $300.00 | Sale −$102,300 | not reported | Yes | Form 4 |
| Lee Chan HenrySVP, General Counsel | Mar 11 | Mar 13 | M · derivative | 1,430 | $14.96 | $21,393 | 22,490 | Yes | Form 4 |
| Lee Chan HenrySVP, General Counsel | Mar 11 | Mar 13 | M · derivative | 1,729 | $16.41 | $28,373 | 86,684 | Yes | Form 4 |
| Lee Chan HenrySVP, General Counsel | Mar 11 | Mar 13 | M · derivative | 1,274 | $12.23 | $15,581 | 110,396 | Yes | Form 4 |
| Oyler JohnChief Executive Officer | Mar 6 | Mar 10 | A | 326,976 | $0.00 | $0 | 5,491,339 | No | Form 4 |
| Oyler JohnChief Executive Officer | Mar 6 | Mar 10 | A | 117,936 | $0.00 | $0 | 5,609,275 | No | Form 4 |
| Wu XiaobinPresident and COO | Mar 6 | Mar 10 | A | 168,922 | $0.00 | $0 | 1,137,900 | No | Form 4 |
| Wu XiaobinPresident and COO | Mar 6 | Mar 10 | A | 78,624 | $0.00 | $0 | 1,216,524 | No | Form 4 |
| Wang LaiPresident, Global Head of R&D | Mar 6 | Mar 10 | A | 112,606 | $0.00 | $0 | 1,564,030 | No | Form 4 |
| Wang LaiPresident, Global Head of R&D | Mar 6 | Mar 10 | A | 55,029 | $0.00 | $0 | 1,619,059 | No | Form 4 |
| Lee Chan HenrySVP, General Counsel | Mar 6 | Mar 10 | A | 65,390 | $0.00 | $0 | 288,496 | No | Form 4 |
| Lee Chan HenrySVP, General Counsel | Mar 6 | Mar 10 | A | 29,874 | $0.00 | $0 | 318,370 | No | Form 4 |
| Rosenberg AaronChief Financial Officer | Mar 6 | Mar 10 | A | 79,014 | $0.00 | $0 | 294,346 | No | Form 4 |
| Rosenberg AaronChief Financial Officer | Mar 6 | Mar 10 | A | 40,573 | $0.00 | $0 | 334,919 | No | Form 4 |
| Lee Chan HenrySVP, General Counsel | Feb 4 | Feb 6 | M | 502 | $194.47 | $97,624 | 502 | Yes | Form 4 |
| Lee Chan HenrySVP, General Counsel | Feb 4 | Feb 6 | M | 662 | $213.32 | $141,218 | 1,164 | Yes | Form 4 |
| Lee Chan HenrySVP, General Counsel | Feb 4 | Feb 6 | M | 496 | $159.03 | $78,879 | 1,660 | Yes | Form 4 |
| Lee Chan HenrySVP, General Counsel | Feb 4 | Feb 6 | S | 664 | $348.79 | Sale −$231,597 | 996 | Yes | Form 4 |
| Lee Chan HenrySVP, General Counsel | Feb 4 | Feb 6 | S | 996 | $350.00 | Sale −$348,600 | not reported | Yes | Form 4 |
| Lee Chan HenrySVP, General Counsel | Feb 4 | Feb 6 | M · derivative | 6,526 | $14.96 | $97,629 | 23,920 | Yes | Form 4 |
| Lee Chan HenrySVP, General Counsel | Feb 4 | Feb 6 | M · derivative | 8,606 | $16.41 | $141,224 | 88,413 | Yes | Form 4 |
| Lee Chan HenrySVP, General Counsel | Feb 4 | Feb 6 | M · derivative | 6,448 | $12.23 | $78,859 | 111,670 | Yes | Form 4 |
| Lee Chan HenrySVP, General Counsel | Jan 7 | Jan 9 | M | 202 | $194.47 | $39,283 | 202 | Yes | Form 4 |
| Lee Chan HenrySVP, General Counsel | Jan 7 | Jan 9 | M | 266 | $213.32 | $56,743 | 468 | Yes | Form 4 |
| Lee Chan HenrySVP, General Counsel | Jan 7 | Jan 9 | M | 196 | $159.03 | $31,170 | 664 | Yes | Form 4 |
| Lee Chan HenrySVP, General Counsel | Jan 7 | Jan 9 | S | 664 | $331.76 | Sale −$220,289 | not reported | Yes | Form 4 |
| Lee Chan HenrySVP, General Counsel | Jan 7 | Jan 9 | M · derivative | 2,626 | $14.96 | $39,285 | 30,446 | Yes | Form 4 |
| Lee Chan HenrySVP, General Counsel | Jan 7 | Jan 9 | M · derivative | 3,458 | $16.41 | $56,746 | 97,019 | Yes | Form 4 |
| Lee Chan HenrySVP, General Counsel | Jan 7 | Jan 9 | M · derivative | 2,548 | $12.23 | $31,162 | 118,118 | Yes | Form 4 |
| Wang LaiPresident, Global Head of R&D | Dec 31, 2025 | Jan 5 | A | 427,895 | $0.00 | $0 | 1,451,424 | No | Form 4 |
| Oyler JohnChief Executive Officer | Dec 16, 2025 | Dec 17, 2025 | S | 1,877 | $300.80 | Sale −$564,602 | 22,492 | Yes | Form 4 |
| Oyler JohnChief Executive Officer | Dec 16, 2025 | Dec 17, 2025 | S | 600 | $300.98 | Sale −$180,588 | 21,892 | Yes | Form 4 |
| Oyler JohnChief Executive Officer | Dec 16, 2025 | Dec 17, 2025 | S | 2,567 | $301.79 | Sale −$774,695 | 19,325 | Yes | Form 4 |
| Oyler JohnChief Executive Officer | Dec 16, 2025 | Dec 17, 2025 | S | 1,512 | $302.31 | Sale −$457,093 | 17,813 | Yes | Form 4 |
| Oyler JohnChief Executive Officer | Dec 16, 2025 | Dec 17, 2025 | S | 7,470 | $302.74 | Sale −$2,261,468 | 10,343 | Yes | Form 4 |
| Oyler JohnChief Executive Officer | Dec 16, 2025 | Dec 17, 2025 | S | 1,633 | $303.13 | Sale −$495,011 | 8,710 | Yes | Form 4 |
| Oyler JohnChief Executive Officer | Dec 16, 2025 | Dec 17, 2025 | S | 5,442 | $303.72 | Sale −$1,652,844 | 3,268 | Yes | Form 4 |
| Oyler JohnChief Executive Officer | Dec 16, 2025 | Dec 17, 2025 | S | 1,255 | $304.13 | Sale −$381,683 | 2,013 | Yes | Form 4 |
| Oyler JohnChief Executive Officer | Dec 16, 2025 | Dec 17, 2025 | S | 1,973 | $304.36 | Sale −$600,502 | 40 | Yes | Form 4 |
| Oyler JohnChief Executive Officer | Dec 16, 2025 | Dec 17, 2025 | S | 40 | $305.24 | Sale −$12,210 | not reported | Yes | Form 4 |
| Oyler JohnChief Executive Officer | Dec 15, 2025 | Dec 17, 2025 | S | 1,791 | $301.58 | Sale −$540,130 | 98,209 | Yes | Form 4 |
| Oyler JohnChief Executive Officer | Dec 15, 2025 | Dec 17, 2025 | S | 6,389 | $302.29 | Sale −$1,931,331 | 91,820 | Yes | Form 4 |
| Oyler JohnChief Executive Officer | Dec 15, 2025 | Dec 17, 2025 | S | 1,896 | $303.60 | Sale −$575,626 | 89,924 | Yes | Form 4 |
| Oyler JohnChief Executive Officer | Dec 15, 2025 | Dec 17, 2025 | S | 5,829 | $304.37 | Sale −$1,774,173 | 84,095 | Yes | Form 4 |
| Oyler JohnChief Executive Officer | Dec 15, 2025 | Dec 17, 2025 | S | 3,940 | $305.55 | Sale −$1,203,867 | 80,155 | Yes | Form 4 |
| Oyler JohnChief Executive Officer | Dec 15, 2025 | Dec 17, 2025 | S | 4,949 | $306.39 | Sale −$1,516,324 | 75,206 | Yes | Form 4 |
| Oyler JohnChief Executive Officer | Dec 15, 2025 | Dec 17, 2025 | S | 5,118 | $307.38 | Sale −$1,573,171 | 70,088 | Yes | Form 4 |
| Oyler JohnChief Executive Officer | Dec 15, 2025 | Dec 17, 2025 | S | 14,163 | $308.41 | Sale −$4,368,011 | 55,925 | Yes | Form 4 |
| Oyler JohnChief Executive Officer | Dec 15, 2025 | Dec 17, 2025 | S | 10,650 | $309.37 | Sale −$3,294,791 | 45,275 | Yes | Form 4 |
| Oyler JohnChief Executive Officer | Dec 15, 2025 | Dec 17, 2025 | S | 16,318 | $310.48 | Sale −$5,066,413 | 28,957 | Yes | Form 4 |
| Oyler JohnChief Executive Officer | Dec 15, 2025 | Dec 17, 2025 | S | 2,344 | $311.33 | Sale −$729,758 | 26,613 | Yes | Form 4 |
| Oyler JohnChief Executive Officer | Dec 15, 2025 | Dec 17, 2025 | S | 121 | $311.93 | Sale −$37,744 | 26,492 | Yes | Form 4 |
| Oyler JohnChief Executive Officer | Dec 15, 2025 | Dec 17, 2025 | S | 929 | $313.52 | Sale −$291,260 | 25,563 | Yes | Form 4 |
| Oyler JohnChief Executive Officer | Dec 15, 2025 | Dec 17, 2025 | S | 1,194 | $314.92 | Sale −$376,014 | 24,369 | Yes | Form 4 |
| Lee Chan HenrySVP, General Counsel | Dec 11, 2025 | Dec 12, 2025 | M | 101 | $194.47 | $19,641 | 101 | Yes | Form 4 |
| Lee Chan HenrySVP, General Counsel | Dec 11, 2025 | Dec 12, 2025 | M | 133 | $213.32 | $28,372 | 234 | Yes | Form 4 |
| Lee Chan HenrySVP, General Counsel | Dec 11, 2025 | Dec 12, 2025 | M | 98 | $159.03 | $15,585 | 332 | Yes | Form 4 |
| Lee Chan HenrySVP, General Counsel | Dec 11, 2025 | Dec 12, 2025 | S | 332 | $325.00 | Sale −$107,900 | not reported | Yes | Form 4 |
| Lee Chan HenrySVP, General Counsel | Dec 11, 2025 | Dec 12, 2025 | M · derivative | 1,313 | $14.96 | $19,642 | 33,072 | Yes | Form 4 |
| Lee Chan HenrySVP, General Counsel | Dec 11, 2025 | Dec 12, 2025 | M · derivative | 1,729 | $16.41 | $28,373 | 100,477 | Yes | Form 4 |
| Lee Chan HenrySVP, General Counsel | Dec 11, 2025 | Dec 12, 2025 | M · derivative | 1,274 | $12.23 | $15,581 | 120,666 | Yes | Form 4 |
| Lee Chan HenrySVP, General Counsel | Dec 10, 2025 | Dec 12, 2025 | M | 101 | $194.47 | $19,641 | 101 | Yes | Form 4 |
| Lee Chan HenrySVP, General Counsel | Dec 10, 2025 | Dec 12, 2025 | M | 133 | $213.32 | $28,372 | 234 | Yes | Form 4 |
| Lee Chan HenrySVP, General Counsel | Dec 10, 2025 | Dec 12, 2025 | M | 98 | $159.03 | $15,585 | 332 | Yes | Form 4 |
| Lee Chan HenrySVP, General Counsel | Dec 10, 2025 | Dec 12, 2025 | S | 332 | $318.28 | Sale −$105,669 | not reported | Yes | Form 4 |
| Lee Chan HenrySVP, General Counsel | Dec 10, 2025 | Dec 12, 2025 | M · derivative | 1,313 | $14.96 | $19,642 | 34,385 | Yes | Form 4 |
| Lee Chan HenrySVP, General Counsel | Dec 10, 2025 | Dec 12, 2025 | M · derivative | 1,729 | $16.41 | $28,373 | 102,206 | Yes | Form 4 |
| Lee Chan HenrySVP, General Counsel | Dec 10, 2025 | Dec 12, 2025 | M · derivative | 1,274 | $12.23 | $15,581 | 121,940 | Yes | Form 4 |
| Sanders Corazon (Corsee) D. | Nov 26, 2025 | Dec 1, 2025 | M | 2,627 | $159.03 | $417,772 | 2,627 | No | Form 4 |
| Sanders Corazon (Corsee) D. | Nov 26, 2025 | Dec 1, 2025 | S | 1,823 | $340.20 | Sale −$620,185 | 804 | No | Form 4 |
| Sanders Corazon (Corsee) D. | Nov 26, 2025 | Dec 1, 2025 | S | 804 | $342.47 | Sale −$275,346 | not reported | No | Form 4 |
| Sanders Corazon (Corsee) D. | Nov 26, 2025 | Dec 1, 2025 | M · derivative | 34,151 | $12.23 | $417,667 | not reported | No | Form 4 |
| Wu XiaobinPresident and COO | Nov 17, 2025 | Nov 19, 2025 | S | 3,155 | $380.23 | Sale −$1,199,626 | 836 | No | Form 4 |
| Wu XiaobinPresident and COO | Nov 17, 2025 | Nov 19, 2025 | S | 826 | $381.19 | Sale −$314,863 | 10 | No | Form 4 |
| Wu XiaobinPresident and COO | Nov 17, 2025 | Nov 19, 2025 | S | 10 | $382.32 | Sale −$3,823 | not reported | No | Form 4 |
| Wu XiaobinPresident and COO | Nov 13, 2025 | Nov 14, 2025 | S | 4,240 | $380.33 | Sale −$1,612,599 | 1,769 | No | Form 4 |
| Wu XiaobinPresident and COO | Nov 13, 2025 | Nov 14, 2025 | S | 1,769 | $381.05 | Sale −$674,077 | not reported | No | Form 4 |
| Wu XiaobinPresident and COO | Nov 12, 2025 | Nov 14, 2025 | S | 500 | $350.44 | Sale −$175,220 | 15,509 | No | Form 4 |
| Wu XiaobinPresident and COO | Nov 12, 2025 | Nov 14, 2025 | S | 3,240 | $351.41 | Sale −$1,138,568 | 12,269 | No | Form 4 |
| Wu XiaobinPresident and COO | Nov 12, 2025 | Nov 14, 2025 | S | 789 | $352.78 | Sale −$278,343 | 11,480 | No | Form 4 |
| Wu XiaobinPresident and COO | Nov 12, 2025 | Nov 14, 2025 | S | 251 | $354.20 | Sale −$88,904 | 11,229 | No | Form 4 |
| Wu XiaobinPresident and COO | Nov 12, 2025 | Nov 14, 2025 | S | 120 | $355.00 | Sale −$42,600 | 11,109 | No | Form 4 |
| Wu XiaobinPresident and COO | Nov 12, 2025 | Nov 14, 2025 | S | 100 | $357.43 | Sale −$35,743 | 11,009 | No | Form 4 |
| Wu XiaobinPresident and COO | Nov 12, 2025 | Nov 14, 2025 | S | 4,846 | $360.10 | Sale −$1,745,045 | 6,163 | No | Form 4 |
| Wu XiaobinPresident and COO | Nov 12, 2025 | Nov 14, 2025 | S | 154 | $362.07 | Sale −$55,759 | 6,009 | No | Form 4 |
| Lee Chan HenrySVP, General Counsel | Nov 12, 2025 | Nov 14, 2025 | M | 302 | $194.47 | $58,730 | 302 | Yes | Form 4 |
| Lee Chan HenrySVP, General Counsel | Nov 12, 2025 | Nov 14, 2025 | M | 398 | $213.32 | $84,901 | 700 | Yes | Form 4 |
| Lee Chan HenrySVP, General Counsel | Nov 12, 2025 | Nov 14, 2025 | M | 296 | $159.03 | $47,073 | 996 | Yes | Form 4 |
| Lee Chan HenrySVP, General Counsel | Nov 12, 2025 | Nov 14, 2025 | S | 664 | $348.75 | Sale −$231,570 | 332 | Yes | Form 4 |
| Lee Chan HenrySVP, General Counsel | Nov 12, 2025 | Nov 14, 2025 | S | 332 | $350.00 | Sale −$116,200 | not reported | Yes | Form 4 |
| Lee Chan HenrySVP, General Counsel | Nov 12, 2025 | Nov 14, 2025 | M · derivative | 3,926 | $14.96 | $58,733 | 35,698 | Yes | Form 4 |
| Lee Chan HenrySVP, General Counsel | Nov 12, 2025 | Nov 14, 2025 | M · derivative | 5,174 | $16.41 | $84,905 | 103,935 | Yes | Form 4 |
| Lee Chan HenrySVP, General Counsel | Nov 12, 2025 | Nov 14, 2025 | M · derivative | 3,848 | $12.23 | $47,061 | 123,214 | Yes | Form 4 |
| Oyler JohnChief Executive Officer | Nov 12, 2025 | Nov 13, 2025 | G | 858,533 | $0.00 | $0 | 6,441,041 | No | Form 4 |
| Oyler JohnChief Executive Officer | Nov 11, 2025 | Nov 13, 2025 | G | 151,320 | $0.00 | $0 | 7,299,574 | No | Form 4 |
| Wang Xiaodong | Nov 7, 2025 | Nov 12, 2025 | G | 424,073 | $0.00 | $0 | 4,582,601 | No | Form 4 |
| Lee Chan HenrySVP, General Counsel | Oct 8, 2025 | Oct 10, 2025 | S | 1,112 | $350.00 | Sale −$389,200 | not reported | Yes | Form 4 |
| Lee Chan HenrySVP, General Counsel | Oct 8, 2025 | Oct 10, 2025 | M | 302 | $194.47 | $58,730 | 302 | Yes | Form 4 |
| Lee Chan HenrySVP, General Counsel | Oct 8, 2025 | Oct 10, 2025 | M | 8,961 | $213.32 | $1,911,561 | 9,263 | Yes | Form 4 |
| Lee Chan HenrySVP, General Counsel | Oct 8, 2025 | Oct 10, 2025 | M | 296 | $159.03 | $47,073 | 9,559 | Yes | Form 4 |
| Lee Chan HenrySVP, General Counsel | Oct 8, 2025 | Oct 10, 2025 | S | 664 | $347.82 | Sale −$230,952 | 8,895 | Yes | Form 4 |
| Lee Chan HenrySVP, General Counsel | Oct 8, 2025 | Oct 10, 2025 | S | 4,733 | $350.22 | Sale −$1,657,591 | 4,162 | Yes | Form 4 |
| Lee Chan HenrySVP, General Counsel | Oct 8, 2025 | Oct 10, 2025 | S | 4,162 | $351.12 | Sale −$1,461,361 | not reported | Yes | Form 4 |
| Lee Chan HenrySVP, General Counsel | Oct 8, 2025 | Oct 10, 2025 | M · derivative | 3,926 | $14.96 | $58,733 | 39,624 | Yes | Form 4 |
| Lee Chan HenrySVP, General Counsel | Oct 8, 2025 | Oct 10, 2025 | M · derivative | 116,493 | $16.41 | $1,911,650 | 109,109 | Yes | Form 4 |
| Lee Chan HenrySVP, General Counsel | Oct 8, 2025 | Oct 10, 2025 | M · derivative | 3,848 | $12.23 | $47,061 | 127,062 | Yes | Form 4 |
| Oyler JohnChief Executive Officer | Sep 16, 2025 | Sep 18, 2025 | S | 4,066 | $324.12 | Sale −$1,317,872 | 23,737 | Yes | Form 4 |
| Oyler JohnChief Executive Officer | Sep 16, 2025 | Sep 18, 2025 | S | 6,883 | $325.06 | Sale −$2,237,388 | 16,854 | Yes | Form 4 |
| Oyler JohnChief Executive Officer | Sep 16, 2025 | Sep 18, 2025 | S | 12,446 | $326.14 | Sale −$4,059,138 | 4,408 | Yes | Form 4 |
| Oyler JohnChief Executive Officer | Sep 16, 2025 | Sep 18, 2025 | S | 4,008 | $326.90 | Sale −$1,310,215 | 400 | Yes | Form 4 |
| Oyler JohnChief Executive Officer | Sep 16, 2025 | Sep 18, 2025 | S | 400 | $327.78 | Sale −$131,112 | not reported | Yes | Form 4 |
| Lee Chan HenrySVP, General Counsel | Sep 10, 2025 | Sep 12, 2025 | S | 1,112 | $325.00 | Sale −$361,400 | not reported | Yes | Form 4 |
| Lee Chan HenrySVP, General Counsel | Sep 10, 2025 | Sep 12, 2025 | M | 6,802 | $194.47 | $1,322,785 | 6,802 | Yes | Form 4 |
| Lee Chan HenrySVP, General Counsel | Sep 10, 2025 | Sep 12, 2025 | M | 1,796 | $213.32 | $383,123 | 8,598 | Yes | Form 4 |
| Lee Chan HenrySVP, General Counsel | Sep 10, 2025 | Sep 12, 2025 | M | 296 | $159.03 | $47,073 | 8,894 | Yes | Form 4 |
| Lee Chan HenrySVP, General Counsel | Sep 10, 2025 | Sep 12, 2025 | S | 4,776 | $325.19 | Sale −$1,553,107 | 4,118 | Yes | Form 4 |
| Lee Chan HenrySVP, General Counsel | Sep 10, 2025 | Sep 12, 2025 | S | 3,318 | $325.73 | Sale −$1,080,772 | 800 | Yes | Form 4 |
| Lee Chan HenrySVP, General Counsel | Sep 10, 2025 | Sep 12, 2025 | S | 300 | $326.80 | Sale −$98,040 | 500 | Yes | Form 4 |
| Lee Chan HenrySVP, General Counsel | Sep 10, 2025 | Sep 12, 2025 | S | 500 | $327.93 | Sale −$163,965 | not reported | Yes | Form 4 |
| Lee Chan HenrySVP, General Counsel | Sep 10, 2025 | Sep 12, 2025 | M · derivative | 88,426 | $14.96 | $1,322,853 | 43,550 | Yes | Form 4 |
| Lee Chan HenrySVP, General Counsel | Sep 10, 2025 | Sep 12, 2025 | M · derivative | 23,348 | $16.41 | $383,141 | 225,602 | Yes | Form 4 |
| Lee Chan HenrySVP, General Counsel | Sep 10, 2025 | Sep 12, 2025 | M · derivative | 3,848 | $12.23 | $47,061 | 130,910 | Yes | Form 4 |
| Wang LaiGlobal Head of R&D | Sep 9, 2025 | Sep 11, 2025 | S | 5,000 | $350.06 | Sale −$1,750,300 | not reported | Yes | Form 4 |
| Wang Xiaodong | Sep 9, 2025 | Sep 11, 2025 | G | 148,096 | $0.00 | $0 | 5,006,674 | No | Form 4 |
| Sanders Corazon (Corsee) D. | Sep 5, 2025 | Sep 9, 2025 | M | 2,665 | $155.68 | $414,887 | 2,665 | No | Form 4 |
| Sanders Corazon (Corsee) D. | Sep 5, 2025 | Sep 9, 2025 | S | 2,665 | $337.00 | Sale −$898,105 | not reported | No | Form 4 |
| Sanders Corazon (Corsee) D. | Sep 5, 2025 | Sep 9, 2025 | M · derivative | 34,645 | $11.98 | $415,047 | not reported | No | Form 4 |
| Ball Titus B.Principal Accounting Officer | Sep 2, 2025 | Sep 4, 2025 | S | 122 | $326.76 | Sale −$39,865 | not reported | No | Form 4 |
| Wu XiaobinPresident and COO | Aug 14, 2025 | Aug 15, 2025 | M | 30,756 | $155.68 | $4,788,094 | 30,756 | Yes | Form 4 |
| Wu XiaobinPresident and COO | Aug 14, 2025 | Aug 15, 2025 | M | 9,180 | $159.03 | $1,459,895 | 39,936 | Yes | Form 4 |
| Wu XiaobinPresident and COO | Aug 14, 2025 | Aug 15, 2025 | S | 400 | $300.86 | Sale −$120,344 | 39,536 | Yes | Form 4 |
| Wu XiaobinPresident and COO | Aug 14, 2025 | Aug 15, 2025 | S | 5,800 | $302.04 | Sale −$1,751,832 | 33,736 | Yes | Form 4 |
| Wu XiaobinPresident and COO | Aug 14, 2025 | Aug 15, 2025 | S | 6,965 | $303.31 | Sale −$2,112,554 | 26,771 | Yes | Form 4 |
| Wu XiaobinPresident and COO | Aug 14, 2025 | Aug 15, 2025 | S | 500 | $304.19 | Sale −$152,095 | 26,271 | Yes | Form 4 |
| Wu XiaobinPresident and COO | Aug 14, 2025 | Aug 15, 2025 | S | 8,522 | $305.48 | Sale −$2,603,301 | 17,749 | Yes | Form 4 |
| Wu XiaobinPresident and COO | Aug 14, 2025 | Aug 15, 2025 | S | 12,232 | $306.26 | Sale −$3,746,172 | 5,517 | Yes | Form 4 |
| Wu XiaobinPresident and COO | Aug 14, 2025 | Aug 15, 2025 | S | 4,917 | $307.43 | Sale −$1,511,633 | 600 | Yes | Form 4 |
| Wu XiaobinPresident and COO | Aug 14, 2025 | Aug 15, 2025 | S | 600 | $308.03 | Sale −$184,818 | not reported | Yes | Form 4 |
| Wu XiaobinPresident and COO | Aug 14, 2025 | Aug 15, 2025 | M · derivative | 399,828 | $11.98 | $4,789,939 | 309,881 | Yes | Form 4 |
| Wu XiaobinPresident and COO | Aug 14, 2025 | Aug 15, 2025 | M · derivative | 119,340 | $12.23 | $1,459,528 | 358,046 | Yes | Form 4 |
| Lee Chan HenrySVP, General Counsel | Aug 13, 2025 | Aug 15, 2025 | S | 1,112 | $300.00 | Sale −$333,600 | not reported | Yes | Form 4 |
| Lee Chan HenrySVP, General Counsel | Aug 13, 2025 | Aug 15, 2025 | M | 4,381 | $194.47 | $851,973 | 4,381 | Yes | Form 4 |
| Lee Chan HenrySVP, General Counsel | Aug 13, 2025 | Aug 15, 2025 | M | 3,849 | $159.03 | $612,106 | 8,230 | Yes | Form 4 |
| Lee Chan HenrySVP, General Counsel | Aug 13, 2025 | Aug 15, 2025 | S | 6,052 | $300.19 | Sale −$1,816,750 | 2,178 | Yes | Form 4 |
| Lee Chan HenrySVP, General Counsel | Aug 13, 2025 | Aug 15, 2025 | S | 3,849 | $301.00 | Sale −$1,158,549 | not reported | Yes | Form 4 |
| Lee Chan HenrySVP, General Counsel | Aug 13, 2025 | Aug 15, 2025 | M · derivative | 56,953 | $14.96 | $852,017 | 131,976 | Yes | Form 4 |
| Lee Chan HenrySVP, General Counsel | Aug 13, 2025 | Aug 15, 2025 | M · derivative | 50,037 | $12.23 | $611,953 | 134,758 | Yes | Form 4 |
| Wu XiaobinPresident and COO | Aug 13, 2025 | Aug 15, 2025 | M | 22,773 | $174.43 | $3,972,294 | 22,773 | Yes | Form 4 |
| Wu XiaobinPresident and COO | Aug 13, 2025 | Aug 15, 2025 | M | 27,085 | $155.68 | $4,216,593 | 49,858 | Yes | Form 4 |
| Wu XiaobinPresident and COO | Aug 13, 2025 | Aug 15, 2025 | S | 8,900 | $300.33 | Sale −$2,672,937 | 40,958 | Yes | Form 4 |
| Wu XiaobinPresident and COO | Aug 13, 2025 | Aug 15, 2025 | S | 4,500 | $301.49 | Sale −$1,356,705 | 36,458 | Yes | Form 4 |
| Wu XiaobinPresident and COO | Aug 13, 2025 | Aug 15, 2025 | S | 5,800 | $302.45 | Sale −$1,754,210 | 30,658 | Yes | Form 4 |
| Wu XiaobinPresident and COO | Aug 13, 2025 | Aug 15, 2025 | S | 3,517 | $303.54 | Sale −$1,067,550 | 27,141 | Yes | Form 4 |
| Wu XiaobinPresident and COO | Aug 13, 2025 | Aug 15, 2025 | S | 7,359 | $304.37 | Sale −$2,239,859 | 19,782 | Yes | Form 4 |
| Wu XiaobinPresident and COO | Aug 13, 2025 | Aug 15, 2025 | S | 528 | $305.59 | Sale −$161,352 | 19,254 | Yes | Form 4 |
| Wu XiaobinPresident and COO | Aug 13, 2025 | Aug 15, 2025 | S | 9,637 | $306.74 | Sale −$2,956,053 | 9,617 | Yes | Form 4 |
| Wu XiaobinPresident and COO | Aug 13, 2025 | Aug 15, 2025 | S | 9,617 | $307.38 | Sale −$2,956,073 | not reported | Yes | Form 4 |
| Wu XiaobinPresident and COO | Aug 13, 2025 | Aug 15, 2025 | M · derivative | 296,049 | $13.42 | $3,972,978 | not reported | Yes | Form 4 |
| Wu XiaobinPresident and COO | Aug 13, 2025 | Aug 15, 2025 | M · derivative | 352,105 | $11.98 | $4,218,218 | 709,709 | Yes | Form 4 |
| Rosenberg AaronChief Financial Officer | Aug 1, 2025 | Aug 5, 2025 | S | 1,190 | $290.47 | Sale −$345,659 | not reported | No | Form 4 |
| Lee Chan HenrySVP, General Counsel | Jul 30, 2025 | Jul 31, 2025 | S | 920 | $304.60 | Sale −$280,232 | not reported | No | Form 4 |
| Wang LaiGlobal Head of R&D | Jul 30, 2025 | Jul 31, 2025 | S | 259 | $305.00 | Sale −$78,995 | not reported | Yes | Form 4 |
| Wang LaiGlobal Head of R&D | Jul 29, 2025 | Jul 31, 2025 | S | 2,949 | $302.00 | Sale −$890,598 | 1,351 | Yes | Form 4 |
| Wang LaiGlobal Head of R&D | Jul 29, 2025 | Jul 31, 2025 | S | 292 | $302.92 | Sale −$88,453 | 1,059 | Yes | Form 4 |
| Wang LaiGlobal Head of R&D | Jul 29, 2025 | Jul 31, 2025 | S | 800 | $304.16 | Sale −$243,328 | 259 | Yes | Form 4 |
| Wang LaiGlobal Head of R&D | Jul 18, 2025 | Jul 22, 2025 | S | 700 | $300.00 | Sale −$210,000 | not reported | Yes | Form 4 |
| Oyler JohnChief Executive Officer | Jul 9, 2025 | Jul 11, 2025 | S | 6,703 | $252.23 | Sale −$1,690,698 | 21,099 | Yes | Form 4 |
| Oyler JohnChief Executive Officer | Jul 9, 2025 | Jul 11, 2025 | S | 9,292 | $253.18 | Sale −$2,352,549 | 11,807 | Yes | Form 4 |
| Oyler JohnChief Executive Officer | Jul 9, 2025 | Jul 11, 2025 | S | 10,254 | $254.10 | Sale −$2,605,541 | 1,553 | Yes | Form 4 |
| Oyler JohnChief Executive Officer | Jul 9, 2025 | Jul 11, 2025 | S | 1,553 | $254.83 | Sale −$395,751 | not reported | Yes | Form 4 |
| Wang Xiaodong | Jun 24, 2025 | Jun 25, 2025 | S | 300 | $263.50 | Sale −$79,050 | 1,707 | Yes | Form 4 |
| Wang Xiaodong | Jun 24, 2025 | Jun 25, 2025 | S | 1,100 | $265.35 | Sale −$291,885 | 607 | Yes | Form 4 |
| Wang Xiaodong | Jun 24, 2025 | Jun 25, 2025 | S | 507 | $266.57 | Sale −$135,151 | 100 | Yes | Form 4 |
| Wang Xiaodong | Jun 24, 2025 | Jun 25, 2025 | S | 100 | $267.81 | Sale −$26,781 | not reported | Yes | Form 4 |
| Oyler JohnChief Executive Officer | Jun 23, 2025 | Jun 25, 2025 | S | 3,074 | $261.57 | Sale −$804,066 | 100 | No | Form 4 |
| Oyler JohnChief Executive Officer | Jun 23, 2025 | Jun 25, 2025 | S | 100 | $262.90 | Sale −$26,290 | not reported | No | Form 4 |
| Wu XiaobinPresident and COO | Jun 23, 2025 | Jun 25, 2025 | S | 1,363 | $260.00 | Sale −$354,380 | not reported | No | Form 4 |
| Wang LaiGlobal Head of R&D | Jun 23, 2025 | Jun 25, 2025 | S | 1,028 | $260.00 | Sale −$267,280 | not reported | No | Form 4 |
| Oyler JohnChief Executive Officer | Jun 17, 2025 | Jun 18, 2025 | S | 1,460 | $256.49 | Sale −$374,475 | not reported | No | Form 4 |
| Wu XiaobinPresident and COO | Jun 17, 2025 | Jun 18, 2025 | S | 630 | $250.87 | Sale −$158,048 | not reported | No | Form 4 |
| Wang LaiGlobal Head of R&D | Jun 17, 2025 | Jun 18, 2025 | S | 470 | $251.37 | Sale −$118,144 | not reported | No | Form 4 |
| Oyler JohnChief Executive Officer | Jun 16, 2025 | Jun 18, 2025 | S | 3,680 | $266.05 | Sale −$979,064 | 1,460 | No | Form 4 |
| Wu XiaobinPresident and COO | Jun 16, 2025 | Jun 18, 2025 | S | 1,443 | $265.47 | Sale −$383,073 | 730 | No | Form 4 |
| Wu XiaobinPresident and COO | Jun 16, 2025 | Jun 18, 2025 | S | 100 | $266.22 | Sale −$26,622 | 630 | No | Form 4 |
| Wang LaiGlobal Head of R&D | Jun 16, 2025 | Jun 18, 2025 | S | 1,177 | $266.40 | Sale −$313,553 | 470 | No | Form 4 |
| Lee Chan HenrySVP, General Counsel | Jun 16, 2025 | Jun 18, 2025 | S | 422 | $266.50 | Sale −$112,463 | not reported | No | Form 4 |
| Ball Titus B.Principal Accounting Officer | Jun 11, 2025 | Jun 12, 2025 | S | 134 | $258.36 | Sale −$34,620 | not reported | No | Form 4 |
| Yi Qingqing | Jun 10, 2025 | Jun 12, 2025 | J | 29,614 | $0.00 | $0 | 27,326 | No | Form 4 |
| Oyler JohnChief Executive Officer | Jun 10, 2025 | Jun 12, 2025 | A | 185,055 | $0.00 | $0 | 8,281,841 | No | Form 4 |
| Oyler JohnChief Executive Officer | Jun 10, 2025 | Jun 12, 2025 | A · derivative | 348,374 | $20.26 | $7,058,057 | 348,374 | No | Form 4 |
| Wang Xiaodong | Jun 10, 2025 | Jun 12, 2025 | A | 98,696 | $0.00 | $0 | 5,180,861 | Yes | Form 4 |
| Wang Xiaodong | Jun 10, 2025 | Jun 12, 2025 | M | 41,760 | $6.50 | $271,440 | 41,760 | Yes | Form 4 |
| Wang Xiaodong | Jun 10, 2025 | Jun 12, 2025 | S | 2,901 | $261.20 | Sale −$757,741 | 38,859 | Yes | Form 4 |
| Wang Xiaodong | Jun 10, 2025 | Jun 12, 2025 | S | 15,878 | $262.20 | Sale −$4,163,212 | 22,981 | Yes | Form 4 |
| Wang Xiaodong | Jun 10, 2025 | Jun 12, 2025 | S | 16,094 | $263.17 | Sale −$4,235,458 | 6,887 | Yes | Form 4 |
| Wang Xiaodong | Jun 10, 2025 | Jun 12, 2025 | S | 6,787 | $264.08 | Sale −$1,792,311 | 100 | Yes | Form 4 |
| Wang Xiaodong | Jun 10, 2025 | Jun 12, 2025 | S | 100 | $264.85 | Sale −$26,485 | not reported | Yes | Form 4 |
| Wang Xiaodong | Jun 10, 2025 | Jun 12, 2025 | A · derivative | 185,796 | $20.26 | $3,764,227 | 185,796 | Yes | Form 4 |
| Wang Xiaodong | Jun 10, 2025 | Jun 12, 2025 | M · derivative | 542,880 | $0.50 | $271,440 | 7 | Yes | Form 4 |
| Wu XiaobinPresident and COO | Jun 10, 2025 | Jun 12, 2025 | A | 123,370 | $0.00 | $0 | 1,274,296 | No | Form 4 |
| Wu XiaobinPresident and COO | Jun 10, 2025 | Jun 12, 2025 | A · derivative | 232,245 | $20.26 | $4,705,284 | 232,245 | No | Form 4 |
| Wang LaiGlobal Head of R&D | Jun 10, 2025 | Jun 12, 2025 | A | 86,359 | $0.00 | $0 | 1,058,304 | No | Form 4 |
| Wang LaiGlobal Head of R&D | Jun 10, 2025 | Jun 12, 2025 | A · derivative | 162,565 | $20.26 | $3,293,567 | 162,565 | No | Form 4 |
| Rosenberg AaronChief Financial Officer | Jun 10, 2025 | Jun 12, 2025 | A | 63,674 | $0.00 | $0 | 230,802 | No | Form 4 |
| Rosenberg AaronChief Financial Officer | Jun 10, 2025 | Jun 12, 2025 | A · derivative | 119,873 | $20.26 | $2,428,627 | 119,873 | No | Form 4 |
| Lee Chan HenrySVP, General Counsel | Jun 10, 2025 | Jun 12, 2025 | A | 46,878 | $0.00 | $0 | 283,920 | No | Form 4 |
| Lee Chan HenrySVP, General Counsel | Jun 10, 2025 | Jun 12, 2025 | A · derivative | 88,244 | $20.26 | $1,787,823 | 88,244 | No | Form 4 |
| Ball Titus B.Principal Accounting Officer | Jun 10, 2025 | Jun 12, 2025 | A | 29,601 | $0.00 | $0 | 73,983 | No | Form 4 |
| Oyler JohnChief Executive Officer | Jun 6, 2025 | Jun 10, 2025 | S | 1,400 | $250.84 | Sale −$351,176 | 3,727 | No | Form 4 |
| Oyler JohnChief Executive Officer | Jun 6, 2025 | Jun 10, 2025 | S | 1,400 | $251.88 | Sale −$352,632 | 2,327 | No | Form 4 |
| Oyler JohnChief Executive Officer | Jun 6, 2025 | Jun 10, 2025 | S | 1,000 | $253.49 | Sale −$253,490 | 1,327 | No | Form 4 |
| Oyler JohnChief Executive Officer | Jun 6, 2025 | Jun 10, 2025 | S | 927 | $254.97 | Sale −$236,357 | 400 | No | Form 4 |
| Oyler JohnChief Executive Officer | Jun 6, 2025 | Jun 10, 2025 | S | 400 | $255.74 | Sale −$102,296 | not reported | No | Form 4 |
| Wu XiaobinPresident and COO | Jun 6, 2025 | Jun 10, 2025 | S | 400 | $250.74 | Sale −$100,296 | 1,534 | No | Form 4 |
| Wu XiaobinPresident and COO | Jun 6, 2025 | Jun 10, 2025 | S | 500 | $251.85 | Sale −$125,925 | 1,034 | No | Form 4 |
| Wu XiaobinPresident and COO | Jun 6, 2025 | Jun 10, 2025 | S | 400 | $253.50 | Sale −$101,400 | 634 | No | Form 4 |
| Wu XiaobinPresident and COO | Jun 6, 2025 | Jun 10, 2025 | S | 400 | $255.31 | Sale −$102,124 | 234 | No | Form 4 |
| Wu XiaobinPresident and COO | Jun 6, 2025 | Jun 10, 2025 | S | 234 | $255.77 | Sale −$59,850 | not reported | No | Form 4 |
| Wang LaiGlobal Head of R&D | Jun 6, 2025 | Jun 10, 2025 | S | 600 | $250.71 | Sale −$150,426 | 802 | No | Form 4 |
| Wang LaiGlobal Head of R&D | Jun 6, 2025 | Jun 10, 2025 | S | 202 | $251.89 | Sale −$50,882 | 600 | No | Form 4 |
| Wang LaiGlobal Head of R&D | Jun 6, 2025 | Jun 10, 2025 | S | 300 | $253.19 | Sale −$75,957 | 300 | No | Form 4 |
| Wang LaiGlobal Head of R&D | Jun 6, 2025 | Jun 10, 2025 | S | 300 | $255.30 | Sale −$76,590 | not reported | No | Form 4 |
| Lee Chan HenrySVP, General Counsel | Jun 6, 2025 | Jun 10, 2025 | S | 470 | $255.78 | Sale −$120,217 | 230 | No | Form 4 |
| Lee Chan HenrySVP, General Counsel | Jun 6, 2025 | Jun 10, 2025 | S | 230 | $256.79 | Sale −$59,062 | not reported | No | Form 4 |
| Yi Qingqing | May 21, 2025 | May 23, 2025 | A | 10,985 | $0.00 | $0 | 56,940 | No | Form 4 |
| Yi Qingqing | May 21, 2025 | May 23, 2025 | A · derivative | 22,750 | $18.19 | $413,823 | 22,750 | No | Form 4 |
| Baker Brothers Life Sciences LP | May 21, 2025 | May 22, 2025 | A | 21,970 | $0.00 | $0 | 148,065 | No | Form 4 |
| Baker Brothers Life Sciences LP | May 21, 2025 | May 22, 2025 | A | 21,970 | $0.00 | $0 | 148,069 | No | Form 4 |
| Baker Brothers Life Sciences LP | May 21, 2025 | May 22, 2025 | A · derivative | 45,500 | $18.19 | $827,645 | 45,500 | No | Form 4 |
| Baker Brothers Life Sciences LP | May 21, 2025 | May 22, 2025 | A · derivative | 45,500 | $18.19 | $827,645 | 45,500 | No | Form 4 |
| Hooper Anthony C | May 21, 2025 | May 22, 2025 | A | 10,985 | $0.00 | $0 | 64,740 | No | Form 4 |
| Hooper Anthony C | May 21, 2025 | May 22, 2025 | A · derivative | 22,750 | $18.19 | $413,823 | 22,750 | No | Form 4 |
| Sanders Corazon (Corsee) D. | May 21, 2025 | May 22, 2025 | A | 10,985 | $0.00 | $0 | 57,226 | No | Form 4 |
| Sanders Corazon (Corsee) D. | May 21, 2025 | May 22, 2025 | A · derivative | 22,750 | $18.19 | $413,823 | 22,750 | No | Form 4 |
| Dugan Margaret | May 21, 2025 | May 22, 2025 | A | 10,985 | $0.00 | $0 | 56,940 | No | Form 4 |
| Dugan Margaret | May 21, 2025 | May 22, 2025 | A · derivative | 22,750 | $18.19 | $413,823 | 22,750 | No | Form 4 |
| Riva Alessandro | May 21, 2025 | May 22, 2025 | A | 10,985 | $0.00 | $0 | 56,940 | No | Form 4 |
| Riva Alessandro | May 21, 2025 | May 22, 2025 | A · derivative | 22,750 | $18.19 | $413,823 | 22,750 | No | Form 4 |
| Brandicourt Olivier | May 21, 2025 | May 22, 2025 | A | 10,985 | $0.00 | $0 | 27,326 | No | Form 4 |
| Brandicourt Olivier | May 21, 2025 | May 22, 2025 | A · derivative | 22,750 | $18.19 | $413,823 | 22,750 | No | Form 4 |
| Sharp Shalini | May 21, 2025 | May 22, 2025 | A | 10,985 | $0.00 | $0 | 19,136 | No | Form 4 |
| Sharp Shalini | May 21, 2025 | May 22, 2025 | A · derivative | 22,750 | $18.19 | $413,823 | 22,750 | No | Form 4 |
| Wang Xiaodong | May 13, 2025 | May 15, 2025 | M | 41,760 | $6.50 | $271,440 | 41,760 | Yes | Form 4 |
| Wang Xiaodong | May 13, 2025 | May 15, 2025 | S | 10,221 | $222.83 | Sale −$2,277,545 | 31,539 | Yes | Form 4 |
| Wang Xiaodong | May 13, 2025 | May 15, 2025 | S | 21,235 | $223.41 | Sale −$4,744,111 | 10,304 | Yes | Form 4 |
| Wang Xiaodong | May 13, 2025 | May 15, 2025 | S | 10,104 | $224.32 | Sale −$2,266,529 | 200 | Yes | Form 4 |
| Wang Xiaodong | May 13, 2025 | May 15, 2025 | S | 200 | $225.68 | Sale −$45,136 | not reported | Yes | Form 4 |
| Wang Xiaodong | May 13, 2025 | May 15, 2025 | M · derivative | 542,880 | $0.50 | $271,440 | 542,887 | Yes | Form 4 |
| Oyler JohnChief Executive Officer | May 9, 2025 | May 13, 2025 | M | 4,055,415 | $0.50 | $2,027,708 | 10,154,040 | No | Form 4 |
| Oyler JohnChief Executive Officer | May 9, 2025 | May 13, 2025 | F | 1,990,603 | $17.85 | $35,532,264 | 8,163,437 | No | Form 4 |
| Oyler JohnChief Executive Officer | May 9, 2025 | May 13, 2025 | M · derivative | 4,055,415 | $0.50 | $2,027,708 | 7 | No | Form 4 |
| Wang Xiaodong | Apr 14, 2025 | Apr 16, 2025 | M | 41,760 | $6.50 | $271,440 | 41,760 | Yes | Form 4 |
| Wang Xiaodong | Apr 14, 2025 | Apr 16, 2025 | S | 995 | $237.56 | Sale −$236,372 | 40,765 | Yes | Form 4 |
| Wang Xiaodong | Apr 14, 2025 | Apr 16, 2025 | S | 805 | $238.48 | Sale −$191,976 | 39,960 | Yes | Form 4 |
| Wang Xiaodong | Apr 14, 2025 | Apr 16, 2025 | S | 2,884 | $239.51 | Sale −$690,747 | 37,076 | Yes | Form 4 |
| Wang Xiaodong | Apr 14, 2025 | Apr 16, 2025 | S | 5,516 | $240.41 | Sale −$1,326,102 | 31,560 | Yes | Form 4 |