RAREUltragenyx Pharmaceutical Inc.
- Market cap
- $1.54B
- as of 2026-10-23
- Latest close
- $15.65
- as of 2026-10-23
- Sector
- Healthcare
- as of 2026-10-24
- Industry
- Biotechnology
- as of 2026-10-24
Cluster
No cluster in the last 90 days under the default rule (14d · ≥2 insiders · all roles).
Form 4 historysince 2023-10-10
| Insider | Traded | Filed | Type | Shares | Price | Value | Owned after | 10b5-1 plan | Filing |
|---|---|---|---|---|---|---|---|---|---|
| Horn HowardChief Financial Officer | Oct 15 | Oct 19 | S | 7,066 | $15.27 | Sale −$107,898 | 89,229 | No | Form 4 |
| Huizenga Theodore AlanSVP, Chief Accounting Officer | Sep 15 | Sep 15 | S | 1,283 | $13.57 | Sale −$17,410 | 67,863 | Yes | Form 4 |
| Huizenga Theodore AlanSVP, Chief Accounting Officer | Sep 3 | Sep 8 | S | 161 | $13.99 | Sale −$2,252 | 69,146 | No | Form 4 |
| Horn HowardChief Financial Officer | Aug 3 | Aug 4 | S | 4,696 | $24.92 | Sale −$117,024 | 96,295 | Yes | Form 4 |
| Parschauer Karah HerdmanEVP and Chief Legal Officer | Aug 3 | Aug 4 | S | 1,900 | $24.92 | Sale −$47,348 | 92,562 | Yes | Form 4 |
| Horn HowardChief Financial Officer | Jul 1 | Jul 6 | S | 4,698 | $33.13 | Sale −$155,645 | 100,991 | Yes | Form 4 |
| Parschauer Karah HerdmanEVP and Chief Legal Officer | Jun 15 | Jun 15 | S | 1,899 | $24.62 | Sale −$46,753 | 94,462 | Yes | Form 4 |
| Sanders Corazon (Corsee) D. | Jun 15 | Jun 15 | S | 2,000 | $25.05 | Sale −$50,100 | 21,095 | No | Form 4 |
| Horn HowardChief Financial Officer | Jun 1 | Jun 1 | S | 4,653 | $23.77 | Sale −$110,602 | 105,689 | Yes | Form 4 |
| Suliman Shehnaaz | May 18 | May 18 | S | 5,740 | $25.12 | Sale −$144,189 | 27,951 | Yes | Form 4 |
| Dunsire Deborah | May 14 | May 18 | A | 7,751 | $0.00 | $0 | 38,566 | No | Form 4 |
| Dunsire Deborah | May 14 | May 18 | A · derivative | 14,058 | $25.80 | $362,696 | 14,058 | No | Form 4 |
| Welch Daniel G | May 14 | May 18 | A | 7,751 | $0.00 | $0 | 40,441 | No | Form 4 |
| Welch Daniel G | May 14 | May 18 | A · derivative | 14,058 | $25.80 | $362,696 | 14,058 | No | Form 4 |
| Narachi Michael | May 14 | May 18 | A | 7,751 | $0.00 | $0 | 40,441 | No | Form 4 |
| Narachi Michael | May 14 | May 18 | A · derivative | 14,058 | $25.80 | $362,696 | 14,058 | No | Form 4 |
| Fust Matthew K | May 14 | May 18 | A | 7,751 | $0.00 | $0 | 33,696 | No | Form 4 |
| Fust Matthew K | May 14 | May 18 | A · derivative | 14,058 | $25.80 | $362,696 | 14,058 | No | Form 4 |
| Suliman Shehnaaz | May 14 | May 18 | A | 7,751 | $0.00 | $0 | 33,691 | Yes | Form 4 |
| Suliman Shehnaaz | May 14 | May 18 | A · derivative | 14,058 | $25.80 | $362,696 | 14,058 | Yes | Form 4 |
| Sanders Corazon (Corsee) D. | May 14 | May 18 | A | 7,751 | $0.00 | $0 | 23,095 | No | Form 4 |
| Sanders Corazon (Corsee) D. | May 14 | May 18 | A · derivative | 14,058 | $25.80 | $362,696 | 14,058 | No | Form 4 |
| Ray Amrit | May 14 | May 18 | A | 7,751 | $0.00 | $0 | 31,116 | No | Form 4 |
| Ray Amrit | May 14 | May 18 | A · derivative | 14,058 | $25.80 | $362,696 | 14,058 | No | Form 4 |
| Crombez EricEVP and Chief Medical Officer | May 5 | May 6 | S | 344 | $24.96 | Sale −$8,586 | 111,189 | No | Form 4 |
| Horn HowardChief Financial Officer | May 1 | May 4 | S | 4,683 | $24.90 | Sale −$116,607 | 110,342 | Yes | Form 4 |
| Huizenga Theodore AlanSVP, Chief Accounting Officer | Apr 22 | Apr 24 | A | 20,241 | $0.00 | $0 | 68,911 | No | Form 4 |
| Huizenga Theodore AlanSVP, Chief Accounting Officer | Apr 22 | Apr 24 | A · derivative | 7,348 | $24.61 | $180,834 | 7,348 | No | Form 4 |
| Horn HowardChief Financial Officer | Apr 16 | Apr 20 | A | 34,674 | $0.00 | $0 | 115,025 | No | Form 4 |
| Horn HowardChief Financial Officer | Apr 16 | Apr 20 | A · derivative | 59,952 | $24.52 | $1,470,023 | 59,952 | No | Form 4 |
| Crombez EricEVP and Chief Medical Officer | Apr 16 | Apr 20 | A | 34,674 | $0.00 | $0 | 110,975 | No | Form 4 |
| Crombez EricEVP and Chief Medical Officer | Apr 16 | Apr 20 | A · derivative | 59,952 | $24.52 | $1,470,023 | 59,952 | No | Form 4 |
| Harris ErikEVP & Chief Commercial Officer | Apr 16 | Apr 20 | A | 28,895 | $0.00 | $0 | 118,410 | No | Form 4 |
| Harris ErikEVP & Chief Commercial Officer | Apr 16 | Apr 20 | A · derivative | 49,960 | $24.52 | $1,225,019 | 49,960 | No | Form 4 |
| Parschauer Karah HerdmanEVP and Chief Legal Officer | Apr 16 | Apr 20 | A | 28,895 | $0.00 | $0 | 95,715 | No | Form 4 |
| Parschauer Karah HerdmanEVP and Chief Legal Officer | Apr 16 | Apr 20 | A · derivative | 49,960 | $24.52 | $1,225,019 | 49,960 | No | Form 4 |
| Pinion John RichardSee Remarks | Apr 16 | Apr 20 | A | 23,116 | $0.00 | $0 | 133,142 | No | Form 4 |
| Pinion John RichardSee Remarks | Apr 16 | Apr 20 | A · derivative | 79,936 | $24.52 | $1,960,031 | 79,936 | No | Form 4 |
| Huang Dennis KarlSee Remarks | Apr 16 | Apr 20 | A | 23,116 | $0.00 | $0 | 147,845 | No | Form 4 |
| Huang Dennis KarlSee Remarks | Apr 16 | Apr 20 | A · derivative | 79,936 | $24.52 | $1,960,031 | 79,936 | No | Form 4 |
| Kakkis Emil DPresident & CEO | Apr 16 | Apr 20 | A | 76,745 | $0.00 | $0 | 735,739 | No | Form 4 |
| Kakkis Emil DPresident & CEO | Apr 16 | Apr 20 | A · derivative | 132,693 | $24.52 | $3,253,632 | 132,693 | No | Form 4 |
| Horn HowardChief Financial Officer | Apr 1 | Apr 2 | S | 4,683 | $20.97 | Sale −$98,203 | 80,351 | Yes | Form 4 |
| Parschauer Karah HerdmanEVP and Chief Legal Officer | Mar 10 | Mar 10 | S | 3,508 | $22.67 | Sale −$79,526 | 66,820 | No | Form 4 |
| Parschauer Karah HerdmanEVP and Chief Legal Officer | Mar 6 | Mar 10 | S | 6,018 | $21.40 | Sale −$128,785 | 70,328 | No | Form 4 |
| Horn HowardChief Financial Officer | Mar 3 | Mar 3 | S | 1,635 | $22.40 | Sale −$36,624 | 85,034 | Yes | Form 4 |
| Huang Dennis KarlSee Remarks | Mar 2 | Mar 3 | F | 999 | $23.39 | $23,367 | 124,729 | No | Form 4 |
| Crombez EricEVP and Chief Medical Officer | Mar 2 | Mar 3 | S | 7,029 | $22.80 | Sale −$160,261 | 76,301 | No | Form 4 |
| Horn HowardChief Financial Officer | Mar 2 | Mar 3 | S | 5,290 | $22.80 | Sale −$120,612 | 89,788 | Yes | Form 4 |
| Horn HowardChief Financial Officer | Mar 2 | Mar 3 | S | 3,119 | $22.54 | Sale −$70,302 | 86,669 | Yes | Form 4 |
| Huizenga Theodore AlanSVP, Chief Accounting Officer | Mar 2 | Mar 3 | F | 148 | $23.39 | $3,462 | 50,302 | No | Form 4 |
| Huizenga Theodore AlanSVP, Chief Accounting Officer | Mar 2 | Mar 3 | S | 1,632 | $22.80 | Sale −$37,210 | 48,670 | No | Form 4 |
| Parschauer Karah HerdmanEVP and Chief Legal Officer | Mar 2 | Mar 3 | S | 8,135 | $22.80 | Sale −$185,478 | 76,346 | No | Form 4 |
| Kakkis Emil DPresident & CEO | Mar 2 | Mar 3 | S | 54,404 | $22.80 | Sale −$1,240,411 | 658,994 | No | Form 4 |
| Harris ErikEVP & Chief Commercial Officer | Mar 2 | Mar 3 | S | 10,539 | $22.80 | Sale −$240,289 | 89,515 | No | Form 4 |
| Pinion John RichardSee Remarks | Mar 2 | Mar 3 | S | 10,029 | $22.80 | Sale −$228,661 | 110,026 | No | Form 4 |
| Huang Dennis KarlSee Remarks | Mar 1 | Mar 3 | A | 11,137 | $0.00 | $0 | 125,728 | No | Form 4 |
| Crombez EricEVP and Chief Medical Officer | Mar 1 | Mar 3 | A | 11,643 | $0.00 | $0 | 83,173 | No | Form 4 |
| Horn HowardChief Financial Officer | Mar 1 | Mar 3 | A | 6,143 | $0.00 | $0 | 95,078 | Yes | Form 4 |
| Parschauer Karah HerdmanEVP and Chief Legal Officer | Mar 1 | Mar 3 | A | 11,137 | $0.00 | $0 | 84,408 | No | Form 4 |
| Kakkis Emil DPresident & CEO | Mar 1 | Mar 3 | A | 71,177 | $0.00 | $0 | 712,908 | No | Form 4 |
| Harris ErikEVP & Chief Commercial Officer | Mar 1 | Mar 3 | A | 11,643 | $0.00 | $0 | 99,498 | No | Form 4 |
| Pinion John RichardSee Remarks | Mar 1 | Mar 3 | A | 11,137 | $0.00 | $0 | 119,565 | No | Form 4 |
| Horn HowardChief Financial Officer | Feb 2 | Feb 3 | S | 3,061 | $23.56 | Sale −$72,117 | 88,935 | Yes | Form 4 |
| Horn HowardChief Financial Officer | Jan 2 | Jan 5 | S | 3,150 | $22.84 | Sale −$71,946 | 91,996 | Yes | Form 4 |
| Huizenga Theodore AlanSVP, Chief Accounting Officer | Dec 29, 2025 | Dec 30, 2025 | S | 85 | $34.38 | Sale −$2,922 | 50,450 | No | Form 4 |
| Horn HowardChief Financial Officer | Dec 10, 2025 | Dec 11, 2025 | S | 3,081 | $36.38 | Sale −$112,087 | 95,146 | Yes | Form 4 |
| Horn HowardChief Financial Officer | Oct 13, 2025 | Oct 14, 2025 | S | 7,942 | $31.51 | Sale −$250,252 | 98,227 | No | Form 4 |
| Huizenga Theodore AlanSVP, Chief Accounting Officer | Sep 18, 2025 | Sep 19, 2025 | S | 64 | $29.17 | Sale −$1,867 | 50,242 | No | Form 4 |
| Parschauer Karah HerdmanEVP and Chief Legal Officer | Sep 12, 2025 | Sep 12, 2025 | S | 2,450 | $31.17 | Sale −$76,367 | 73,271 | No | Form 4 |
| Huizenga Theodore AlanSVP, Chief Accounting Officer | Sep 5, 2025 | Sep 8, 2025 | S | 84 | $31.39 | Sale −$2,637 | 50,306 | No | Form 4 |
| Sanders Corazon (Corsee) D. | Jun 20, 2025 | Jun 23, 2025 | S | 2,405 | $37.39 | Sale −$89,923 | 15,344 | Yes | Form 4 |
| Ray Amrit | May 15, 2025 | May 19, 2025 | A | 5,740 | $0.00 | $0 | 23,365 | No | Form 4 |
| Ray Amrit | May 15, 2025 | May 19, 2025 | A · derivative | 10,787 | $34.84 | $375,819 | 10,787 | No | Form 4 |
| Dunsire Deborah | May 15, 2025 | May 19, 2025 | A | 5,740 | $0.00 | $0 | 30,815 | No | Form 4 |
| Dunsire Deborah | May 15, 2025 | May 19, 2025 | A · derivative | 10,787 | $34.84 | $375,819 | 10,787 | No | Form 4 |
| Fust Matthew K | May 15, 2025 | May 19, 2025 | A | 5,740 | $0.00 | $0 | 25,945 | No | Form 4 |
| Fust Matthew K | May 15, 2025 | May 19, 2025 | A · derivative | 10,787 | $34.84 | $375,819 | 10,787 | No | Form 4 |
| Narachi Michael | May 15, 2025 | May 19, 2025 | A | 5,740 | $0.00 | $0 | 32,690 | No | Form 4 |
| Narachi Michael | May 15, 2025 | May 19, 2025 | A · derivative | 10,787 | $34.84 | $375,819 | 10,787 | No | Form 4 |
| Sanders Corazon (Corsee) D. | May 15, 2025 | May 19, 2025 | A | 5,740 | $0.00 | $0 | 17,749 | No | Form 4 |
| Sanders Corazon (Corsee) D. | May 15, 2025 | May 19, 2025 | A · derivative | 10,787 | $34.84 | $375,819 | 10,787 | No | Form 4 |
| Welch Daniel G | May 15, 2025 | May 19, 2025 | A | 5,740 | $0.00 | $0 | 32,690 | No | Form 4 |
| Welch Daniel G | May 15, 2025 | May 19, 2025 | A · derivative | 10,787 | $34.84 | $375,819 | 10,787 | No | Form 4 |
| Suliman Shehnaaz | May 15, 2025 | May 19, 2025 | A | 5,740 | $0.00 | $0 | 25,940 | No | Form 4 |
| Suliman Shehnaaz | May 15, 2025 | May 19, 2025 | A · derivative | 10,787 | $34.84 | $375,819 | 10,787 | No | Form 4 |
| Crombez EricEVP and Chief Medical Officer | May 5, 2025 | May 5, 2025 | S | 520 | $39.24 | Sale −$20,405 | 71,530 | No | Form 4 |
| Crombez EricEVP and Chief Medical Officer | Apr 21, 2025 | May 5, 2025 | S | 242 | $35.11 | Sale −$8,497 | 71,680 | No | Form 4 |
| Horn HowardChief Financial Officer | Mar 6, 2025 | Mar 10, 2025 | S | 1,785 | $40.40 | Sale −$72,114 | 106,169 | No | Form 4 |
| Huizenga Theodore AlanSVP, Chief Accounting Officer | Mar 3, 2025 | Mar 4, 2025 | S | 967 | $42.10 | Sale −$40,711 | 50,265 | No | Form 4 |
| Huizenga Theodore AlanSVP, Chief Accounting Officer | Mar 3, 2025 | Mar 4, 2025 | F | 141 | $42.92 | $6,052 | 50,124 | No | Form 4 |
| Huang Dennis KarlSee Remarks | Mar 3, 2025 | Mar 4, 2025 | F | 1,348 | $42.92 | $57,856 | 114,591 | No | Form 4 |
| Harris ErikEVP & Chief Commercial Officer | Mar 3, 2025 | Mar 4, 2025 | S | 15,103 | $42.10 | Sale −$635,836 | 87,855 | No | Form 4 |
| Kakkis Emil DPresident & CEO | Mar 3, 2025 | Mar 4, 2025 | S | 73,434 | $42.10 | Sale −$3,091,571 | 641,731 | Yes | Form 4 |
| Pinion John RichardSee Remarks | Mar 3, 2025 | Mar 4, 2025 | S | 14,439 | $42.10 | Sale −$607,882 | 107,766 | No | Form 4 |
| Pinion John RichardSee Remarks | Mar 3, 2025 | Mar 4, 2025 | F | 31 | $42.92 | $1,331 | 108,428 | No | Form 4 |
| Crombez EricEVP and Chief Medical Officer | Mar 3, 2025 | Mar 4, 2025 | S | 8,945 | $42.10 | Sale −$376,585 | 71,922 | No | Form 4 |
| Parschauer Karah HerdmanEVP and Chief Legal Officer | Mar 3, 2025 | Mar 4, 2025 | S | 12,846 | $42.10 | Sale −$540,817 | 75,287 | No | Form 4 |
| Kassberg Thomas RichardCBO & EVP | Mar 3, 2025 | Mar 4, 2025 | S | 6,028 | $42.10 | Sale −$253,779 | 265,238 | No | Form 4 |
| Kassberg Thomas RichardCBO & EVP | Mar 3, 2025 | Mar 4, 2025 | F | 508 | $42.92 | $21,803 | 264,730 | No | Form 4 |
| Horn HowardChief Financial Officer | Mar 1, 2025 | Mar 4, 2025 | A | 15,653 | $0.00 | $0 | 107,954 | No | Form 4 |
| Horn HowardChief Financial Officer | Mar 1, 2025 | Mar 4, 2025 | A · derivative | 28,160 | $42.92 | $1,208,627 | 28,160 | No | Form 4 |
| Huizenga Theodore AlanSVP, Chief Accounting Officer | Mar 1, 2025 | Mar 4, 2025 | A | 9,392 | $0.00 | $0 | 51,232 | No | Form 4 |
| Huizenga Theodore AlanSVP, Chief Accounting Officer | Mar 1, 2025 | Mar 4, 2025 | A · derivative | 5,632 | $42.92 | $241,725 | 5,632 | No | Form 4 |
| Huang Dennis KarlSee Remarks | Mar 1, 2025 | Mar 4, 2025 | A | 14,494 | $0.00 | $0 | 97,496 | No | Form 4 |
| Huang Dennis KarlSee Remarks | Mar 1, 2025 | Mar 4, 2025 | A | 18,443 | $0.00 | $0 | 115,939 | No | Form 4 |
| Huang Dennis KarlSee Remarks | Mar 1, 2025 | Mar 4, 2025 | A · derivative | 26,074 | $42.92 | $1,119,096 | 26,074 | No | Form 4 |
| Harris ErikEVP & Chief Commercial Officer | Mar 1, 2025 | Mar 4, 2025 | A | 16,813 | $0.00 | $0 | 83,976 | No | Form 4 |
| Harris ErikEVP & Chief Commercial Officer | Mar 1, 2025 | Mar 4, 2025 | A | 18,443 | $0.00 | $0 | 102,419 | No | Form 4 |
| Harris ErikEVP & Chief Commercial Officer | Mar 1, 2025 | Mar 4, 2025 | A · derivative | 30,246 | $42.92 | $1,298,158 | 30,246 | No | Form 4 |
| Kakkis Emil DPresident & CEO | Mar 1, 2025 | Mar 4, 2025 | A | 43,268 | $0.00 | $0 | 607,873 | Yes | Form 4 |
| Kakkis Emil DPresident & CEO | Mar 1, 2025 | Mar 4, 2025 | A | 107,292 | $0.00 | $0 | 715,165 | Yes | Form 4 |
| Kakkis Emil DPresident & CEO | Mar 1, 2025 | Mar 4, 2025 | A · derivative | 78,448 | $42.92 | $3,366,988 | 78,448 | Yes | Form 4 |
| Pinion John RichardSee Remarks | Mar 1, 2025 | Mar 4, 2025 | A | 14,494 | $0.00 | $0 | 103,762 | No | Form 4 |
| Pinion John RichardSee Remarks | Mar 1, 2025 | Mar 4, 2025 | A | 18,443 | $0.00 | $0 | 122,205 | No | Form 4 |
| Pinion John RichardSee Remarks | Mar 1, 2025 | Mar 4, 2025 | A · derivative | 26,074 | $42.92 | $1,119,096 | 26,074 | No | Form 4 |
| Crombez EricEVP and Chief Medical Officer | Mar 1, 2025 | Mar 4, 2025 | A | 16,813 | $0.00 | $0 | 65,244 | No | Form 4 |
| Crombez EricEVP and Chief Medical Officer | Mar 1, 2025 | Mar 4, 2025 | A | 14,971 | $0.00 | $0 | 80,215 | No | Form 4 |
| Crombez EricEVP and Chief Medical Officer | Mar 1, 2025 | Mar 4, 2025 | A · derivative | 30,246 | $42.92 | $1,298,158 | 30,246 | No | Form 4 |
| Parschauer Karah HerdmanEVP and Chief Legal Officer | Mar 1, 2025 | Mar 4, 2025 | A | 18,443 | $0.00 | $0 | 88,133 | No | Form 4 |
| Kassberg Thomas RichardCBO & EVP | Mar 1, 2025 | Mar 4, 2025 | A | 18,443 | $0.00 | $0 | 271,266 | No | Form 4 |
| Kakkis Emil DPresident & CEO | Feb 28, 2025 | Mar 4, 2025 | S | 25,000 | $42.48 | Sale −$1,062,000 | 2,158,985 | Yes | Form 4 |
| Parschauer Karah HerdmanEVP and Chief Legal Officer | Mar 1, 2025 | Mar 3, 2025 | A | 14,494 | $0.00 | $0 | 69,690 | No | Form 4 |
| Parschauer Karah HerdmanEVP and Chief Legal Officer | Mar 1, 2025 | Mar 3, 2025 | A · derivative | 26,074 | $42.92 | $1,119,096 | 26,074 | No | Form 4 |
| Parschauer Karah HerdmanEVP and Chief Legal Officer | Feb 27, 2025 | Mar 3, 2025 | S | 2,230 | $42.93 | Sale −$95,734 | 55,751 | No | Form 4 |
| Parschauer Karah HerdmanEVP and Chief Legal Officer | Feb 27, 2025 | Mar 3, 2025 | S | 760 | $42.75 | Sale −$32,490 | 54,991 | No | Form 4 |
| Kakkis Emil DPresident & CEO | Dec 30, 2024 | Dec 31, 2024 | S | 11,727 | $42.23 | Sale −$495,231 | 2,183,985 | Yes | Form 4 |
| Kakkis Emil DPresident & CEO | Dec 10, 2024 | Dec 11, 2024 | S | 8,273 | $50.00 | Sale −$413,650 | 2,195,712 | Yes | Form 4 |
| Huizenga Theodore AlanSVP, Chief Accounting Officer | Dec 10, 2024 | Dec 11, 2024 | G | 648 | $0.00 | $0 | 41,840 | No | Form 4 |
| Kakkis Emil DPresident & CEO | Dec 9, 2024 | Dec 11, 2024 | G | 20,000 | $0.00 | $0 | 2,203,985 | Yes | Form 4 |
| Horn HowardChief Financial Officer | Oct 10, 2024 | Oct 11, 2024 | S | 7,465 | $52.76 | Sale −$393,853 | 92,301 | No | Form 4 |
| Huizenga Theodore AlanSVP, Chief Accounting Officer | Sep 16, 2024 | Sep 18, 2024 | A | 700 | $0.00 | $0 | 42,251 | No | Form 4 |
| Huizenga Theodore AlanSVP, Chief Accounting Officer | Sep 3, 2024 | Sep 5, 2024 | S | 91 | $56.19 | Sale −$5,113 | 41,551 | No | Form 4 |
| Kakkis Emil DPresident & CEO | Sep 3, 2024 | Sep 5, 2024 | S | 20,000 | $55.85 | Sale −$1,117,000 | 2,223,985 | Yes | Form 4 |
| Kakkis Emil DPresident & CEO | Aug 6, 2024 | Aug 7, 2024 | S | 20,000 | $50.17 | Sale −$1,003,400 | 2,243,985 | Yes | Form 4 |
| Sanders Corazon (Corsee) D. | Jul 2, 2024 | Jul 3, 2024 | S | 584 | $40.98 | Sale −$23,932 | 12,009 | Yes | Form 4 |
| Suliman Shehnaaz | Jun 18, 2024 | Jun 20, 2024 | A | 5,345 | $0.00 | $0 | 20,200 | No | Form 4 |
| Suliman Shehnaaz | Jun 18, 2024 | Jun 20, 2024 | A · derivative | 9,900 | $37.42 | $370,458 | 9,900 | No | Form 4 |
| Sanders Corazon (Corsee) D. | Jun 18, 2024 | Jun 20, 2024 | A | 5,345 | $0.00 | $0 | 12,593 | No | Form 4 |
| Sanders Corazon (Corsee) D. | Jun 18, 2024 | Jun 20, 2024 | A · derivative | 9,900 | $37.42 | $370,458 | 9,900 | No | Form 4 |
| Ray Amrit | Jun 18, 2024 | Jun 20, 2024 | A | 5,345 | $0.00 | $0 | 17,625 | No | Form 4 |
| Ray Amrit | Jun 18, 2024 | Jun 20, 2024 | A · derivative | 9,900 | $37.42 | $370,458 | 9,900 | No | Form 4 |
| Narachi Michael | Jun 18, 2024 | Jun 20, 2024 | A | 5,345 | $0.00 | $0 | 26,950 | No | Form 4 |
| Narachi Michael | Jun 18, 2024 | Jun 20, 2024 | A · derivative | 9,900 | $37.42 | $370,458 | 9,900 | No | Form 4 |
| Welch Daniel G | Jun 18, 2024 | Jun 20, 2024 | A | 5,345 | $0.00 | $0 | 26,950 | No | Form 4 |
| Welch Daniel G | Jun 18, 2024 | Jun 20, 2024 | A · derivative | 9,900 | $37.42 | $370,458 | 9,900 | No | Form 4 |
| Fust Matthew K | Jun 18, 2024 | Jun 20, 2024 | A | 5,345 | $0.00 | $0 | 20,205 | No | Form 4 |
| Fust Matthew K | Jun 18, 2024 | Jun 20, 2024 | A · derivative | 9,900 | $37.42 | $370,458 | 9,900 | No | Form 4 |
| Dunsire Deborah | Jun 18, 2024 | Jun 20, 2024 | A | 5,345 | $0.00 | $0 | 25,075 | No | Form 4 |
| Dunsire Deborah | Jun 18, 2024 | Jun 20, 2024 | A · derivative | 9,900 | $37.42 | $370,458 | 9,900 | No | Form 4 |
| Parschauer Karah HerdmanEVP and Chief Legal Officer | Jun 12, 2024 | Jun 12, 2024 | S | 9,806 | $45.00 | Sale −$441,270 | 57,981 | Yes | Form 4 |
| Sanders Corazon (Corsee) D. | Jun 10, 2024 | Jun 10, 2024 | S | 1,737 | $41.10 | Sale −$71,391 | 7,248 | Yes | Form 4 |
| Crombez EricEVP and Chief Medical Officer | May 2, 2024 | May 3, 2024 | S | 354 | $43.66 | Sale −$15,456 | 48,431 | No | Form 4 |
| Crombez EricEVP and Chief Medical Officer | Apr 18, 2024 | Apr 19, 2024 | S | 142 | $44.10 | Sale −$6,262 | 48,785 | No | Form 4 |
| Huizenga Theodore AlanSVP, Chief Accounting Officer | Apr 16, 2024 | Apr 18, 2024 | F | 14 | $42.31 | $592 | 41,366 | No | Form 4 |
| Kassberg Thomas RichardCBO & EVP | Mar 11, 2024 | Mar 12, 2024 | S | 11,509 | $49.93 | Sale −$574,644 | 252,823 | No | Form 4 |
| Fust Matthew K | Mar 7, 2024 | Mar 11, 2024 | S | 2,550 | $50.89 | Sale −$129,770 | 24,505 | Yes | Form 4 |
| Fust Matthew K | Mar 7, 2024 | Mar 11, 2024 | S | 2,145 | $50.85 | Sale −$109,073 | 22,360 | Yes | Form 4 |
| Fust Matthew K | Mar 7, 2024 | Mar 11, 2024 | S | 7,500 | $50.88 | Sale −$381,600 | 14,860 | Yes | Form 4 |
| Kakkis Emil DPresident & CEO | Mar 1, 2024 | Mar 5, 2024 | A | 38,428 | $0.00 | $0 | 578,198 | No | Form 4 |
| Kakkis Emil DPresident & CEO | Mar 1, 2024 | Mar 5, 2024 | F | 17,417 | $53.69 | $935,119 | 560,781 | No | Form 4 |
| Kakkis Emil DPresident & CEO | Mar 1, 2024 | Mar 5, 2024 | A | 3,132 | $0.00 | $0 | 563,913 | No | Form 4 |
| Kakkis Emil DPresident & CEO | Mar 1, 2024 | Mar 5, 2024 | A · derivative | 70,094 | $53.69 | $3,763,347 | 70,094 | No | Form 4 |
| Harris ErikEVP & Chief Commercial Officer | Mar 1, 2024 | Mar 5, 2024 | A | 19,400 | $0.00 | $0 | 70,681 | No | Form 4 |
| Harris ErikEVP & Chief Commercial Officer | Mar 1, 2024 | Mar 5, 2024 | A | 957 | $0.00 | $0 | 71,638 | No | Form 4 |
| Harris ErikEVP & Chief Commercial Officer | Mar 1, 2024 | Mar 5, 2024 | S | 4,768 | $53.76 | Sale −$256,328 | 67,163 | No | Form 4 |
| Harris ErikEVP & Chief Commercial Officer | Mar 1, 2024 | Mar 5, 2024 | A · derivative | 34,200 | $53.69 | $1,836,198 | 34,200 | No | Form 4 |
| Crombez EricEVP and Chief Medical Officer | Mar 1, 2024 | Mar 5, 2024 | A | 19,400 | $0.00 | $0 | 49,912 | No | Form 4 |
| Crombez EricEVP and Chief Medical Officer | Mar 1, 2024 | Mar 5, 2024 | S | 1,238 | $53.76 | Sale −$66,555 | 48,927 | No | Form 4 |
| Crombez EricEVP and Chief Medical Officer | Mar 1, 2024 | Mar 5, 2024 | A · derivative | 34,200 | $53.69 | $1,836,198 | 34,200 | No | Form 4 |
| Crombez EricEVP and Chief Medical Officer | Mar 1, 2024 | Mar 5, 2024 | A · derivative | 2,351 | $67.37 | $158,387 | 2,351 | No | Form 4 |
| Huizenga Theodore AlanSVP, Chief Accounting Officer | Mar 1, 2024 | Mar 5, 2024 | A | 13,950 | $0.00 | $0 | 41,842 | No | Form 4 |
| Huizenga Theodore AlanSVP, Chief Accounting Officer | Mar 1, 2024 | Mar 5, 2024 | F | 121 | $53.69 | $6,496 | 41,721 | No | Form 4 |
| Huizenga Theodore AlanSVP, Chief Accounting Officer | Mar 1, 2024 | Mar 5, 2024 | S | 341 | $53.76 | Sale −$18,332 | 41,380 | No | Form 4 |
| Huizenga Theodore AlanSVP, Chief Accounting Officer | Mar 1, 2024 | Mar 5, 2024 | A · derivative | 8,200 | $53.69 | $440,258 | 8,200 | No | Form 4 |
| Huizenga Theodore AlanSVP, Chief Accounting Officer | Mar 1, 2024 | Mar 5, 2024 | A · derivative | 2,351 | $67.37 | $158,387 | 2,351 | No | Form 4 |
| Pinion John RichardSee Remarks | Mar 1, 2024 | Mar 5, 2024 | A | 17,800 | $0.00 | $0 | 92,544 | No | Form 4 |
| Pinion John RichardSee Remarks | Mar 1, 2024 | Mar 5, 2024 | A | 957 | $0.00 | $0 | 93,501 | No | Form 4 |
| Pinion John RichardSee Remarks | Mar 1, 2024 | Mar 5, 2024 | F | 60 | $53.69 | $3,221 | 93,441 | No | Form 4 |
| Pinion John RichardSee Remarks | Mar 1, 2024 | Mar 5, 2024 | S | 4,173 | $53.76 | Sale −$224,340 | 89,268 | No | Form 4 |
| Pinion John RichardSee Remarks | Mar 1, 2024 | Mar 5, 2024 | A · derivative | 31,400 | $53.69 | $1,685,866 | 31,400 | No | Form 4 |
| Huang Dennis KarlSee Remarks | Mar 1, 2024 | Mar 5, 2024 | A | 17,800 | $0.00 | $0 | 82,515 | No | Form 4 |
| Huang Dennis KarlSee Remarks | Mar 1, 2024 | Mar 5, 2024 | A | 957 | $0.00 | $0 | 83,472 | No | Form 4 |
| Huang Dennis KarlSee Remarks | Mar 1, 2024 | Mar 5, 2024 | F | 470 | $53.69 | $25,234 | 83,002 | No | Form 4 |
| Huang Dennis KarlSee Remarks | Mar 1, 2024 | Mar 5, 2024 | A · derivative | 31,400 | $53.69 | $1,685,866 | 31,400 | No | Form 4 |
| Kassberg Thomas RichardCBO & EVP | Mar 1, 2024 | Mar 5, 2024 | A | 17,800 | $0.00 | $0 | 264,660 | No | Form 4 |
| Kassberg Thomas RichardCBO & EVP | Mar 1, 2024 | Mar 5, 2024 | A | 957 | $0.00 | $0 | 265,617 | No | Form 4 |
| Kassberg Thomas RichardCBO & EVP | Mar 1, 2024 | Mar 5, 2024 | F | 274 | $53.69 | $14,711 | 265,343 | No | Form 4 |
| Kassberg Thomas RichardCBO & EVP | Mar 1, 2024 | Mar 5, 2024 | S | 1,011 | $53.76 | Sale −$54,351 | 264,332 | No | Form 4 |
| Kassberg Thomas RichardCBO & EVP | Mar 1, 2024 | Mar 5, 2024 | A · derivative | 31,400 | $53.69 | $1,685,866 | 31,400 | No | Form 4 |
| Parschauer Karah HerdmanEVP and Chief Legal Officer | Mar 1, 2024 | Mar 5, 2024 | A | 17,800 | $0.00 | $0 | 69,782 | No | Form 4 |
| Parschauer Karah HerdmanEVP and Chief Legal Officer | Mar 1, 2024 | Mar 5, 2024 | A | 957 | $0.00 | $0 | 70,739 | No | Form 4 |
| Parschauer Karah HerdmanEVP and Chief Legal Officer | Mar 1, 2024 | Mar 5, 2024 | S | 3,756 | $53.76 | Sale −$201,923 | 67,340 | No | Form 4 |
| Parschauer Karah HerdmanEVP and Chief Legal Officer | Mar 1, 2024 | Mar 5, 2024 | A · derivative | 31,400 | $53.69 | $1,685,866 | 31,400 | No | Form 4 |
| Horn HowardChief Financial Officer | Mar 1, 2024 | Mar 5, 2024 | A | 19,400 | $0.00 | $0 | 99,766 | No | Form 4 |
| Horn HowardChief Financial Officer | Mar 1, 2024 | Mar 5, 2024 | A · derivative | 34,200 | $53.69 | $1,836,198 | 34,200 | No | Form 4 |
| Kakkis Emil DPresident & CEO | Feb 7, 2024 | Feb 8, 2024 | S | 30,000 | $45.00 | Sale −$1,350,000 | 539,770 | No | Form 4 |
| Huizenga Theodore AlanSVP, Chief Accounting Officer | Jan 2, 2024 | Jan 2, 2024 | M | 3,000 | $21.00 | $63,000 | 27,892 | No | Form 4 |
| Huizenga Theodore AlanSVP, Chief Accounting Officer | Jan 2, 2024 | Jan 2, 2024 | M · derivative | 3,000 | $21.00 | $63,000 | not reported | No | Form 4 |
| Kakkis Emil DPresident & CEO | Dec 29, 2023 | Jan 2, 2024 | S | 30,000 | $47.87 | Sale −$1,436,100 | 569,770 | No | Form 4 |
| Huizenga Theodore AlanSVP, Chief Accounting Officer | Dec 20, 2023 | Jan 2, 2024 | A | 1,000 | $0.00 | $0 | 24,614 | No | Form 4 |
| Kassberg Thomas RichardCBO & EVP | Oct 23, 2023 | Oct 24, 2023 | M | 39,878 | $6.86 | $273,563 | 286,738 | Yes | Form 4 |
| Kassberg Thomas RichardCBO & EVP | Oct 23, 2023 | Oct 24, 2023 | S | 39,878 | $32.78 | Sale −$1,307,201 | 246,860 | Yes | Form 4 |
| Kassberg Thomas RichardCBO & EVP | Oct 23, 2023 | Oct 24, 2023 | M · derivative | 39,878 | $6.86 | $273,563 | not reported | Yes | Form 4 |
| Kakkis Emil DPresident & CEO | Oct 19, 2023 | Oct 23, 2023 | M | 47,853 | $6.86 | $328,272 | 647,029 | No | Form 4 |
| Kakkis Emil DPresident & CEO | Oct 19, 2023 | Oct 23, 2023 | S | 47,853 | $33.52 | Sale −$1,604,033 | 599,743 | No | Form 4 |
| Kakkis Emil DPresident & CEO | Oct 19, 2023 | Oct 23, 2023 | M · derivative | 47,853 | $6.86 | $328,272 | not reported | No | Form 4 |
| Horn HowardChief Financial Officer | Oct 9, 2023 | Oct 10, 2023 | A | 80,366 | $0.00 | $0 | 80,336 | No | Form 4 |
| Horn HowardChief Financial Officer | Oct 9, 2023 | Oct 10, 2023 | A · derivative | 140,469 | $35.68 | $5,011,934 | 140,469 | No | Form 4 |