RVMDRevolution Medicines, Inc.
- Market cap
- $40.08B
- as of 2026-10-23
- Latest close
- $186.99
- as of 2026-10-23
- Sector
- Healthcare
- as of 2026-10-24
- Industry
- Biotechnology
- as of 2026-10-24
Cluster
No cluster in the last 90 days under the default rule (14d · ≥2 insiders · all roles).
Form 4 historysince 2023-10-02
Dashed line = amended filing (Form 4/A)
Showing the latest 500 of 547 transactions.
| Insider | Traded | Filed | Type | Shares | Price | Value | Owned after | 10b5-1 plan | Filing |
|---|---|---|---|---|---|---|---|---|---|
| Sandler Alan B.Chief Development Officer | Sep 29 | Oct 1 | M | 6,000 | $58.84 | $353,040 | 58,868 | Yes | Form 4 |
| Sandler Alan B.Chief Development Officer | Sep 29 | Oct 1 | S | 2,200 | $200.82 | Sale −$441,801 | 56,668 | Yes | Form 4 |
| Sandler Alan B.Chief Development Officer | Sep 29 | Oct 1 | S | 1,609 | $201.72 | Sale −$324,574 | 55,059 | Yes | Form 4 |
| Sandler Alan B.Chief Development Officer | Sep 29 | Oct 1 | S | 1,000 | $202.81 | Sale −$202,813 | 54,059 | Yes | Form 4 |
| Sandler Alan B.Chief Development Officer | Sep 29 | Oct 1 | S | 1,199 | $203.91 | Sale −$244,485 | 52,860 | Yes | Form 4 |
| Sandler Alan B.Chief Development Officer | Sep 29 | Oct 1 | S | 301 | $204.72 | Sale −$61,621 | 52,559 | Yes | Form 4 |
| Sandler Alan B.Chief Development Officer | Sep 29 | Oct 1 | M · derivative | 6,000 | $58.84 | $353,040 | 161,300 | Yes | Form 4 |
| Cislini JeffSVP & General Counsel | Sep 25 | Sep 29 | S | 765 | $207.32 | Sale −$158,600 | 51,776 | Yes | Form 4 |
| Mancini AnthonySee Remarks | Sep 25 | Sep 28 | M | 3,121 | $33.62 | $104,928 | 42,886 | Yes | Form 4 |
| Mancini AnthonySee Remarks | Sep 25 | Sep 28 | S | 3,121 | $200.54 | Sale −$625,885 | 39,765 | Yes | Form 4 |
| Mancini AnthonySee Remarks | Sep 25 | Sep 28 | M · derivative | 3,121 | $33.62 | $104,928 | 93,625 | Yes | Form 4 |
| Mancini AnthonySee Remarks | Sep 24 | Sep 28 | S | 587 | $200.00 | Sale −$117,400 | 39,765 | Yes | Form 4 |
| Anderson Elizabeth M | Sep 22 | Sep 24 | M | 5,070 | $1.12 | $5,678 | 14,476 | Yes | Form 4 |
| Anderson Elizabeth M | Sep 22 | Sep 24 | S | 910 | $191.85 | Sale −$174,584 | 13,566 | Yes | Form 4 |
| Anderson Elizabeth M | Sep 22 | Sep 24 | S | 4,985 | $192.54 | Sale −$959,812 | 8,581 | Yes | Form 4 |
| Anderson Elizabeth M | Sep 22 | Sep 24 | S | 2,648 | $193.44 | Sale −$512,229 | 5,933 | Yes | Form 4 |
| Anderson Elizabeth M | Sep 22 | Sep 24 | S | 1,500 | $194.59 | Sale −$291,885 | 4,433 | Yes | Form 4 |
| Anderson Elizabeth M | Sep 22 | Sep 24 | S | 100 | $195.15 | Sale −$19,515 | 4,333 | Yes | Form 4 |
| Anderson Elizabeth M | Sep 22 | Sep 24 | M · derivative | 5,070 | $1.12 | $5,678 | 1,095 | Yes | Form 4 |
| Mancini AnthonySee Remarks | Sep 18 | Sep 22 | S | 1,764 | $196.94 | Sale −$347,402 | 40,352 | Yes | Form 4 |
| Goldsmith Mark ASee Remarks | Sep 16 | Sep 18 | S | 213 | $195.01 | Sale −$41,537 | 267,117 | Yes | Form 4 |
| Goldsmith Mark ASee Remarks | Sep 16 | Sep 18 | S | 13,775 | $199.30 | Sale −$2,745,358 | 253,342 | Yes | Form 4 |
| Horn Margaret AChief Operating Officer | Sep 16 | Sep 18 | S | 76 | $195.01 | Sale −$14,821 | 154,571 | Yes | Form 4 |
| Horn Margaret AChief Operating Officer | Sep 16 | Sep 18 | S | 4,891 | $199.30 | Sale −$974,776 | 149,680 | Yes | Form 4 |
| Kelsey Stephen MichaelSee Remarks | Sep 16 | Sep 18 | S | 85 | $195.01 | Sale −$16,576 | 291,791 | Yes | Form 4 |
| Kelsey Stephen MichaelSee Remarks | Sep 16 | Sep 18 | S | 5,484 | $199.30 | Sale −$1,092,961 | 286,307 | Yes | Form 4 |
| Anders JackChief Financial Officer | Sep 16 | Sep 18 | S | 61 | $195.00 | Sale −$11,895 | 123,208 | Yes | Form 4 |
| Anders JackChief Financial Officer | Sep 16 | Sep 18 | S | 3,992 | $199.30 | Sale −$795,606 | 119,216 | Yes | Form 4 |
| Sandler Alan B.Chief Development Officer | Sep 16 | Sep 18 | S | 5 | $194.96 | Sale −$975 | 53,204 | Yes | Form 4 |
| Sandler Alan B.Chief Development Officer | Sep 16 | Sep 18 | S | 336 | $199.30 | Sale −$66,965 | 52,868 | Yes | Form 4 |
| Cislini JeffSVP & General Counsel | Sep 16 | Sep 18 | S | 52 | $195.01 | Sale −$10,141 | 55,855 | Yes | Form 4 |
| Cislini JeffSVP & General Counsel | Sep 16 | Sep 18 | S | 3,314 | $199.30 | Sale −$660,480 | 52,541 | Yes | Form 4 |
| Mancini AnthonySee Remarks | Sep 16 | Sep 18 | S | 27 | $195.05 | Sale −$5,266 | 43,863 | Yes | Form 4 |
| Mancini AnthonySee Remarks | Sep 16 | Sep 18 | S | 1,747 | $199.30 | Sale −$348,177 | 42,116 | Yes | Form 4 |
| Kelsey Stephen MichaelSee Remarks | Sep 11 | Sep 15 | M | 52,500 | $42.45 | $2,228,625 | 344,376 | Yes | Form 4 |
| Kelsey Stephen MichaelSee Remarks | Sep 11 | Sep 15 | M | 40,031 | $40.74 | $1,630,863 | 384,407 | Yes | Form 4 |
| Kelsey Stephen MichaelSee Remarks | Sep 11 | Sep 15 | S | 800 | $198.55 | Sale −$158,840 | 383,607 | Yes | Form 4 |
| Kelsey Stephen MichaelSee Remarks | Sep 11 | Sep 15 | S | 11,833 | $200.11 | Sale −$2,367,902 | 371,774 | Yes | Form 4 |
| Kelsey Stephen MichaelSee Remarks | Sep 11 | Sep 15 | S | 13,368 | $200.78 | Sale −$2,684,027 | 358,406 | Yes | Form 4 |
| Kelsey Stephen MichaelSee Remarks | Sep 11 | Sep 15 | S | 21,447 | $201.75 | Sale −$4,326,932 | 336,959 | Yes | Form 4 |
| Kelsey Stephen MichaelSee Remarks | Sep 11 | Sep 15 | S | 18,869 | $203.06 | Sale −$3,831,539 | 318,090 | Yes | Form 4 |
| Kelsey Stephen MichaelSee Remarks | Sep 11 | Sep 15 | S | 17,949 | $203.87 | Sale −$3,659,263 | 300,141 | Yes | Form 4 |
| Kelsey Stephen MichaelSee Remarks | Sep 11 | Sep 15 | S | 4,995 | $204.84 | Sale −$1,023,176 | 295,146 | Yes | Form 4 |
| Kelsey Stephen MichaelSee Remarks | Sep 11 | Sep 15 | S | 3,270 | $205.81 | Sale −$672,999 | 291,876 | Yes | Form 4 |
| Kelsey Stephen MichaelSee Remarks | Sep 11 | Sep 15 | M · derivative | 52,500 | $42.45 | $2,228,625 | not reported | Yes | Form 4 |
| Kelsey Stephen MichaelSee Remarks | Sep 11 | Sep 15 | M · derivative | 40,031 | $40.74 | $1,630,863 | 88,069 | Yes | Form 4 |
| Mancini AnthonySee Remarks | Sep 10 | Sep 14 | M | 9,363 | $33.62 | $314,784 | 59,338 | Yes | Form 4 |
| Mancini AnthonySee Remarks | Sep 10 | Sep 14 | S | 6,019 | $203.28 | Sale −$1,223,542 | 53,319 | Yes | Form 4 |
| Mancini AnthonySee Remarks | Sep 10 | Sep 14 | S | 5,530 | $204.14 | Sale −$1,128,894 | 47,789 | Yes | Form 4 |
| Mancini AnthonySee Remarks | Sep 10 | Sep 14 | S | 2,420 | $205.05 | Sale −$496,221 | 45,369 | Yes | Form 4 |
| Mancini AnthonySee Remarks | Sep 10 | Sep 14 | S | 1,179 | $206.10 | Sale −$242,992 | 44,190 | Yes | Form 4 |
| Mancini AnthonySee Remarks | Sep 10 | Sep 14 | S | 300 | $207.17 | Sale −$62,151 | 43,890 | Yes | Form 4 |
| Mancini AnthonySee Remarks | Sep 10 | Sep 14 | M · derivative | 9,363 | $33.62 | $314,784 | 96,746 | Yes | Form 4 |
| Kim Lorence H. | Sep 8 | Sep 10 | S | 706 | $206.60 | Sale −$145,860 | 16,384 | Yes | Form 4 |
| Kim Lorence H. | Sep 8 | Sep 10 | S | 999 | $207.33 | Sale −$207,123 | 15,385 | Yes | Form 4 |
| Kim Lorence H. | Sep 8 | Sep 10 | S | 3,587 | $208.55 | Sale −$748,069 | 11,798 | Yes | Form 4 |
| Kim Lorence H. | Sep 8 | Sep 10 | S | 2,853 | $209.56 | Sale −$597,875 | 8,945 | Yes | Form 4 |
| Kim Lorence H. | Sep 8 | Sep 10 | S | 4,730 | $210.50 | Sale −$995,665 | 4,215 | Yes | Form 4 |
| Kim Lorence H. | Sep 8 | Sep 10 | S | 3,844 | $211.36 | Sale −$812,468 | 371 | Yes | Form 4 |
| Kim Lorence H. | Sep 8 | Sep 10 | S | 371 | $212.27 | Sale −$78,752 | not reported | Yes | Form 4 |
| Kim Lorence H. | Aug 31 | Sep 2 | S | 300 | $200.56 | Sale −$60,168 | 72,790 | Yes | Form 4 |
| Kim Lorence H. | Aug 31 | Sep 2 | S | 6,597 | $201.47 | Sale −$1,329,098 | 66,193 | Yes | Form 4 |
| Kim Lorence H. | Aug 31 | Sep 2 | S | 12,919 | $202.48 | Sale −$2,615,839 | 53,274 | Yes | Form 4 |
| Kim Lorence H. | Aug 31 | Sep 2 | S | 26,160 | $203.55 | Sale −$5,324,868 | 27,114 | Yes | Form 4 |
| Kim Lorence H. | Aug 31 | Sep 2 | S | 7,271 | $204.35 | Sale −$1,485,829 | 19,843 | Yes | Form 4 |
| Kim Lorence H. | Aug 31 | Sep 2 | S | 2,128 | $205.19 | Sale −$436,644 | 17,715 | Yes | Form 4 |
| Kim Lorence H. | Aug 31 | Sep 2 | S | 625 | $206.15 | Sale −$128,844 | 17,090 | Yes | Form 4 |
| Goldsmith Mark ASee Remarks | Aug 21 | Aug 25 | M | 80,000 | $4.73 | $378,400 | 347,330 | Yes | Form 4 |
| Goldsmith Mark ASee Remarks | Aug 21 | Aug 25 | S | 5,128 | $207.23 | Sale −$1,062,675 | 342,202 | Yes | Form 4 |
| Goldsmith Mark ASee Remarks | Aug 21 | Aug 25 | S | 24,917 | $208.37 | Sale −$5,191,955 | 317,285 | Yes | Form 4 |
| Goldsmith Mark ASee Remarks | Aug 21 | Aug 25 | S | 35,938 | $209.26 | Sale −$7,520,386 | 281,347 | Yes | Form 4 |
| Goldsmith Mark ASee Remarks | Aug 21 | Aug 25 | S | 3,813 | $210.25 | Sale −$801,683 | 277,534 | Yes | Form 4 |
| Goldsmith Mark ASee Remarks | Aug 21 | Aug 25 | S | 6,583 | $211.33 | Sale −$1,391,185 | 270,951 | Yes | Form 4 |
| Goldsmith Mark ASee Remarks | Aug 21 | Aug 25 | S | 3,621 | $212.08 | Sale −$767,942 | 267,330 | Yes | Form 4 |
| Goldsmith Mark ASee Remarks | Aug 21 | Aug 25 | S | 190 | $207.25 | Sale −$39,378 | 64,234 | Yes | Form 4 |
| Goldsmith Mark ASee Remarks | Aug 21 | Aug 25 | S | 951 | $208.36 | Sale −$198,150 | 63,283 | Yes | Form 4 |
| Goldsmith Mark ASee Remarks | Aug 21 | Aug 25 | S | 1,351 | $209.28 | Sale −$282,737 | 61,932 | Yes | Form 4 |
| Goldsmith Mark ASee Remarks | Aug 21 | Aug 25 | S | 136 | $210.40 | Sale −$28,614 | 61,796 | Yes | Form 4 |
| Goldsmith Mark ASee Remarks | Aug 21 | Aug 25 | S | 245 | $211.47 | Sale −$51,810 | 61,551 | Yes | Form 4 |
| Goldsmith Mark ASee Remarks | Aug 21 | Aug 25 | S | 127 | $212.06 | Sale −$26,932 | 61,424 | Yes | Form 4 |
| Goldsmith Mark ASee Remarks | Aug 21 | Aug 25 | S | 177 | $207.25 | Sale −$36,683 | 64,247 | Yes | Form 4 |
| Goldsmith Mark ASee Remarks | Aug 21 | Aug 25 | S | 937 | $208.36 | Sale −$195,233 | 63,310 | Yes | Form 4 |
| Goldsmith Mark ASee Remarks | Aug 21 | Aug 25 | S | 1,405 | $209.27 | Sale −$294,024 | 61,905 | Yes | Form 4 |
| Goldsmith Mark ASee Remarks | Aug 21 | Aug 25 | S | 126 | $210.40 | Sale −$26,510 | 61,779 | Yes | Form 4 |
| Goldsmith Mark ASee Remarks | Aug 21 | Aug 25 | S | 229 | $211.46 | Sale −$48,424 | 61,550 | Yes | Form 4 |
| Goldsmith Mark ASee Remarks | Aug 21 | Aug 25 | S | 126 | $212.06 | Sale −$26,720 | 61,424 | Yes | Form 4 |
| Goldsmith Mark ASee Remarks | Aug 21 | Aug 25 | M · derivative | 80,000 | $4.73 | $378,400 | 344,085 | Yes | Form 4 |
| Cislini JeffGeneral Counsel | Aug 21 | Aug 25 | M | 29,680 | $18.56 | $550,861 | 86,201 | Yes | Form 4 |
| Cislini JeffGeneral Counsel | Aug 21 | Aug 25 | M | 26,600 | $21.61 | $574,826 | 112,801 | Yes | Form 4 |
| Cislini JeffGeneral Counsel | Aug 21 | Aug 25 | S | 3,400 | $207.24 | Sale −$704,616 | 109,401 | Yes | Form 4 |
| Cislini JeffGeneral Counsel | Aug 21 | Aug 25 | S | 17,323 | $208.37 | Sale −$3,609,594 | 92,078 | Yes | Form 4 |
| Cislini JeffGeneral Counsel | Aug 21 | Aug 25 | S | 25,817 | $209.25 | Sale −$5,402,207 | 66,261 | Yes | Form 4 |
| Cislini JeffGeneral Counsel | Aug 21 | Aug 25 | S | 2,540 | $210.26 | Sale −$534,060 | 63,721 | Yes | Form 4 |
| Cislini JeffGeneral Counsel | Aug 21 | Aug 25 | S | 4,500 | $211.34 | Sale −$951,030 | 59,221 | Yes | Form 4 |
| Cislini JeffGeneral Counsel | Aug 21 | Aug 25 | S | 3,314 | $212.06 | Sale −$702,767 | 55,907 | Yes | Form 4 |
| Cislini JeffGeneral Counsel | Aug 21 | Aug 25 | M · derivative | 29,680 | $18.56 | $550,861 | not reported | Yes | Form 4 |
| Cislini JeffGeneral Counsel | Aug 21 | Aug 25 | M · derivative | 26,600 | $21.61 | $574,826 | 3,500 | Yes | Form 4 |
| Patel Sushil | Jun 29 | Jul 1 | M | 2,955 | $37.54 | $110,931 | 27,236 | Yes | Form 4 |
| Patel Sushil | Jun 29 | Jul 1 | S | 300 | $183.17 | Sale −$54,951 | 26,936 | Yes | Form 4 |
| Patel Sushil | Jun 29 | Jul 1 | S | 900 | $184.59 | Sale −$166,131 | 26,036 | Yes | Form 4 |
| Patel Sushil | Jun 29 | Jul 1 | S | 1,100 | $185.90 | Sale −$204,490 | 24,936 | Yes | Form 4 |
| Patel Sushil | Jun 29 | Jul 1 | S | 858 | $186.92 | Sale −$160,377 | 24,078 | Yes | Form 4 |
| Patel Sushil | Jun 29 | Jul 1 | S | 300 | $187.83 | Sale −$56,349 | 23,778 | Yes | Form 4 |
| Patel Sushil | Jun 29 | Jul 1 | S | 100 | $188.57 | Sale −$18,857 | 23,678 | Yes | Form 4 |
| Patel Sushil | Jun 29 | Jul 1 | S | 600 | $190.55 | Sale −$114,330 | 23,078 | Yes | Form 4 |
| Patel Sushil | Jun 29 | Jul 1 | S | 541 | $191.87 | Sale −$103,802 | 22,537 | Yes | Form 4 |
| Patel Sushil | Jun 29 | Jul 1 | S | 881 | $192.61 | Sale −$169,689 | 21,656 | Yes | Form 4 |
| Patel Sushil | Jun 29 | Jul 1 | M · derivative | 2,955 | $37.54 | $110,931 | 13,000 | Yes | Form 4 |
| Anders JackChief Financial Officer | Jun 24 | Jun 26 | M | 20,000 | $18.56 | $371,200 | 143,269 | Yes | Form 4 |
| Anders JackChief Financial Officer | Jun 24 | Jun 26 | S | 4,553 | $167.35 | Sale −$761,945 | 138,716 | Yes | Form 4 |
| Anders JackChief Financial Officer | Jun 24 | Jun 26 | S | 9,496 | $168.20 | Sale −$1,597,227 | 129,220 | Yes | Form 4 |
| Anders JackChief Financial Officer | Jun 24 | Jun 26 | S | 5,651 | $169.24 | Sale −$956,375 | 123,569 | Yes | Form 4 |
| Anders JackChief Financial Officer | Jun 24 | Jun 26 | S | 300 | $170.32 | Sale −$51,096 | 123,269 | Yes | Form 4 |
| Anders JackChief Financial Officer | Jun 24 | Jun 26 | M · derivative | 20,000 | $18.56 | $371,200 | 20,600 | Yes | Form 4 |
| Borellini Flavia | Jun 18 | Jun 23 | A | 1,191 | $0.00 | $0 | 26,215 | No | Form 4 |
| Borellini Flavia | Jun 18 | Jun 23 | A · derivative | 3,127 | $162.99 | $509,670 | 3,127 | No | Form 4 |
| Patel Sushil | Jun 18 | Jun 23 | A | 1,191 | $0.00 | $0 | 24,281 | No | Form 4 |
| Patel Sushil | Jun 18 | Jun 23 | A · derivative | 3,127 | $162.99 | $509,670 | 3,127 | No | Form 4 |
| Clyburn Frank | Jun 18 | Jun 23 | A | 1,191 | $0.00 | $0 | 10,929 | No | Form 4 |
| Clyburn Frank | Jun 18 | Jun 23 | A · derivative | 3,127 | $162.99 | $509,670 | 3,127 | No | Form 4 |
| Horning Sandra | Jun 18 | Jun 23 | A | 1,191 | $0.00 | $0 | 97,765 | No | Form 4 |
| Horning Sandra | Jun 18 | Jun 23 | A · derivative | 3,127 | $162.99 | $509,670 | 3,127 | No | Form 4 |
| Anderson Elizabeth M | Jun 18 | Jun 23 | A | 1,191 | $0.00 | $0 | 9,406 | No | Form 4 |
| Anderson Elizabeth M | Jun 18 | Jun 23 | A · derivative | 3,127 | $162.99 | $509,670 | 3,127 | No | Form 4 |
| Borisy Alexis | Jun 18 | Jun 23 | A | 1,191 | $0.00 | $0 | 2,340,075 | No | Form 4 |
| Borisy Alexis | Jun 18 | Jun 23 | A · derivative | 3,127 | $162.99 | $509,670 | 3,127 | No | Form 4 |
| Kim Lorence H. | Jun 18 | Jun 23 | A | 1,191 | $0.00 | $0 | 74,281 | No | Form 4 |
| Kim Lorence H. | Jun 18 | Jun 23 | A · derivative | 3,127 | $162.99 | $509,670 | 3,127 | No | Form 4 |
| Kelsey Stephen MichaelSee Remarks | Jun 16 | Jun 18 | S | 4,175 | $156.12 | Sale −$651,801 | 291,876 | Yes | Form 4 |
| Anders JackChief Financial Officer | Jun 16 | Jun 18 | S | 2,722 | $156.12 | Sale −$424,959 | 123,269 | Yes | Form 4 |
| Cislini JeffGeneral Counsel | Jun 16 | Jun 18 | S | 2,157 | $156.12 | Sale −$336,751 | 56,521 | Yes | Form 4 |
| Goldsmith Mark ASee Remarks | Jun 16 | Jun 18 | S | 10,020 | $156.12 | Sale −$1,564,322 | 267,330 | Yes | Form 4 |
| Mancini AnthonySee Remarks | Jun 16 | Jun 18 | S | 4,615 | $156.12 | Sale −$720,494 | 49,975 | No | Form 4 |
| Horn Margaret AChief Operating Officer | Jun 17 | Jun 17 | M | 573 | $40.74 | $23,344 | 155,220 | Yes | Form 4 |
| Horn Margaret AChief Operating Officer | Jun 17 | Jun 17 | M | 3,302 | $29.80 | $98,400 | 158,522 | Yes | Form 4 |
| Horn Margaret AChief Operating Officer | Jun 17 | Jun 17 | M | 25,725 | $26.50 | $681,713 | 184,247 | Yes | Form 4 |
| Horn Margaret AChief Operating Officer | Jun 17 | Jun 17 | S | 29,600 | $160.12 | Sale −$4,739,552 | 154,647 | Yes | Form 4 |
| Horn Margaret AChief Operating Officer | Jun 17 | Jun 17 | M · derivative | 573 | $40.74 | $23,344 | 75,075 | Yes | Form 4 |
| Horn Margaret AChief Operating Officer | Jun 17 | Jun 17 | M · derivative | 3,302 | $29.80 | $98,400 | 71,750 | Yes | Form 4 |
| Horn Margaret AChief Operating Officer | Jun 17 | Jun 17 | M · derivative | 25,725 | $26.50 | $681,713 | 114,275 | Yes | Form 4 |
| Horn Margaret AChief Operating Officer | Jun 15 | Jun 17 | M | 15,546 | $40.74 | $633,344 | 173,768 | Yes | Form 4 |
| Horn Margaret AChief Operating Officer | Jun 15 | Jun 17 | M | 44,854 | $29.80 | $1,336,649 | 218,622 | Yes | Form 4 |
| Horn Margaret AChief Operating Officer | Jun 15 | Jun 17 | S | 60,400 | $160.17 | Sale −$9,674,268 | 158,222 | Yes | Form 4 |
| Horn Margaret AChief Operating Officer | Jun 15 | Jun 17 | M · derivative | 15,546 | $40.74 | $633,344 | 75,648 | Yes | Form 4 |
| Horn Margaret AChief Operating Officer | Jun 15 | Jun 17 | M · derivative | 44,854 | $29.80 | $1,336,649 | 75,052 | Yes | Form 4 |
| Horn Margaret AChief Operating Officer | Jun 16, 2025 | Jun 17 | S | 3,575 | $156.12 | Sale −$558,129 | 154,647 | Yes | Form 4 |
| Horn Margaret AChief Operating Officer | Jun 11 | Jun 15 | M | 1,094 | $42.45 | $46,440 | 159,316 | Yes | Form 4 |
| Horn Margaret AChief Operating Officer | Jun 11 | Jun 15 | M | 8,906 | $40.74 | $362,830 | 168,222 | Yes | Form 4 |
| Horn Margaret AChief Operating Officer | Jun 11 | Jun 15 | S | 1,315 | $144.28 | Sale −$189,728 | 166,907 | Yes | Form 4 |
| Horn Margaret AChief Operating Officer | Jun 11 | Jun 15 | S | 885 | $145.15 | Sale −$128,458 | 166,022 | Yes | Form 4 |
| Horn Margaret AChief Operating Officer | Jun 11 | Jun 15 | S | 700 | $146.04 | Sale −$102,228 | 165,322 | Yes | Form 4 |
| Horn Margaret AChief Operating Officer | Jun 11 | Jun 15 | S | 500 | $147.27 | Sale −$73,635 | 164,822 | Yes | Form 4 |
| Horn Margaret AChief Operating Officer | Jun 11 | Jun 15 | S | 1,800 | $148.72 | Sale −$267,696 | 163,022 | Yes | Form 4 |
| Horn Margaret AChief Operating Officer | Jun 11 | Jun 15 | S | 4,600 | $149.64 | Sale −$688,344 | 158,422 | Yes | Form 4 |
| Horn Margaret AChief Operating Officer | Jun 11 | Jun 15 | S | 200 | $150.17 | Sale −$30,034 | 158,222 | Yes | Form 4 |
| Horn Margaret AChief Operating Officer | Jun 11 | Jun 15 | M · derivative | 1,094 | $42.45 | $46,440 | not reported | Yes | Form 4 |
| Horn Margaret AChief Operating Officer | Jun 11 | Jun 15 | M · derivative | 8,906 | $40.74 | $362,830 | 91,194 | Yes | Form 4 |
| Mancini AnthonySee Remarks | May 26 | May 28 | M | 3,121 | $33.62 | $104,928 | 57,521 | Yes | Form 4 |
| Mancini AnthonySee Remarks | May 26 | May 28 | S | 700 | $153.30 | Sale −$107,310 | 56,821 | Yes | Form 4 |
| Mancini AnthonySee Remarks | May 26 | May 28 | S | 2,000 | $154.06 | Sale −$308,120 | 54,821 | Yes | Form 4 |
| Mancini AnthonySee Remarks | May 26 | May 28 | S | 421 | $154.82 | Sale −$65,179 | 54,400 | Yes | Form 4 |
| Mancini AnthonySee Remarks | May 26 | May 28 | M · derivative | 3,121 | $33.62 | $104,928 | 106,109 | Yes | Form 4 |
| Mancini AnthonySee Remarks | Apr 27 | Apr 29 | M | 3,120 | $33.62 | $104,894 | 57,520 | Yes | Form 4 |
| Mancini AnthonySee Remarks | Apr 27 | Apr 29 | S | 1,671 | $131.66 | Sale −$220,004 | 55,849 | Yes | Form 4 |
| Mancini AnthonySee Remarks | Apr 27 | Apr 29 | S | 1,049 | $132.88 | Sale −$139,391 | 54,800 | Yes | Form 4 |
| Mancini AnthonySee Remarks | Apr 27 | Apr 29 | S | 400 | $134.34 | Sale −$53,736 | 54,400 | Yes | Form 4 |
| Mancini AnthonySee Remarks | Apr 27 | Apr 29 | M · derivative | 3,120 | $33.62 | $104,894 | 109,230 | Yes | Form 4 |
| Goldsmith Mark ASee Remarks | Apr 15 | Apr 17 | M | 23,244 | $4.09 | $95,068 | 299,942 | Yes | Form 4 |
| Goldsmith Mark ASee Remarks | Apr 15 | Apr 17 | M | 96,756 | $4.73 | $457,656 | 396,698 | Yes | Form 4 |
| Goldsmith Mark ASee Remarks | Apr 15 | Apr 17 | S | 120,000 | $150.09 | Sale −$18,010,800 | 276,698 | Yes | Form 4 |
| Goldsmith Mark ASee Remarks | Apr 15 | Apr 17 | M · derivative | 23,244 | $4.09 | $95,068 | 24,464 | Yes | Form 4 |
| Goldsmith Mark ASee Remarks | Apr 15 | Apr 17 | M · derivative | 96,756 | $4.73 | $457,656 | 424,085 | Yes | Form 4 |
| Mancini AnthonySee Remarks | Mar 25 | Mar 26 | M | 37,450 | $33.62 | $1,259,069 | 91,850 | Yes | Form 4 |
| Mancini AnthonySee Remarks | Mar 25 | Mar 26 | S | 1,800 | $93.22 | Sale −$167,796 | 90,050 | Yes | Form 4 |
| Mancini AnthonySee Remarks | Mar 25 | Mar 26 | S | 3,128 | $94.16 | Sale −$294,532 | 86,922 | Yes | Form 4 |
| Mancini AnthonySee Remarks | Mar 25 | Mar 26 | S | 21,086 | $95.49 | Sale −$2,013,502 | 65,836 | Yes | Form 4 |
| Mancini AnthonySee Remarks | Mar 25 | Mar 26 | S | 11,036 | $96.43 | Sale −$1,064,201 | 54,800 | Yes | Form 4 |
| Mancini AnthonySee Remarks | Mar 25 | Mar 26 | S | 400 | $97.21 | Sale −$38,884 | 54,400 | Yes | Form 4 |
| Mancini AnthonySee Remarks | Mar 25 | Mar 26 | M · derivative | 37,450 | $33.62 | $1,259,069 | 112,350 | Yes | Form 4 |
| Cislini JeffGeneral Counsel | Mar 19 | Mar 19 | S | 1,163 | $97.44 | Sale −$113,323 | 58,518 | Yes | Form 4 |
| Wang XiaolinSee Remarks | Mar 17 | Mar 19 | S | 2,010 | $99.48 | Sale −$199,955 | 116,063 | Yes | Form 4 |
| Cislini JeffGeneral Counsel | Mar 17 | Mar 19 | S | 1,795 | $99.48 | Sale −$178,567 | 59,681 | Yes | Form 4 |
| Anders JackChief Financial Officer | Mar 17 | Mar 19 | S | 2,753 | $99.48 | Sale −$273,868 | 125,512 | Yes | Form 4 |
| Horn Margaret AChief Operating Officer | Mar 17 | Mar 19 | S | 4,583 | $99.48 | Sale −$455,917 | 157,570 | Yes | Form 4 |
| Goldsmith Mark ASee Remarks | Mar 17 | Mar 19 | S | 12,871 | $99.48 | Sale −$1,280,407 | 276,698 | Yes | Form 4 |
| Kelsey Stephen MichaelSee Remarks | Mar 17 | Mar 19 | S | 4,302 | $99.48 | Sale −$427,963 | 295,398 | Yes | Form 4 |
| Wei LinChief Medical Officer | Mar 17 | Mar 19 | S | 2,073 | $99.48 | Sale −$206,222 | 101,366 | Yes | Form 4 |
| Anderson Elizabeth M | Mar 4 | Mar 6 | G | 15,000 | $0.00 | $0 | 8,215 | No | Form 4 |
| Anderson Elizabeth M | Mar 4 | Mar 6 | G | 15,000 | $0.00 | $0 | 15,000 | No | Form 4 |
| Goldsmith Mark ASee Remarks | Mar 2 | Mar 3 | M | 30,000 | $4.09 | $122,700 | 319,569 | Yes | Form 4 |
| Goldsmith Mark ASee Remarks | Mar 2 | Mar 3 | S | 700 | $98.17 | Sale −$68,719 | 318,869 | Yes | Form 4 |
| Goldsmith Mark ASee Remarks | Mar 2 | Mar 3 | S | 3,500 | $99.76 | Sale −$349,160 | 315,369 | Yes | Form 4 |
| Goldsmith Mark ASee Remarks | Mar 2 | Mar 3 | S | 3,620 | $100.73 | Sale −$364,643 | 311,749 | Yes | Form 4 |
| Goldsmith Mark ASee Remarks | Mar 2 | Mar 3 | S | 21,329 | $101.60 | Sale −$2,167,026 | 290,420 | Yes | Form 4 |
| Goldsmith Mark ASee Remarks | Mar 2 | Mar 3 | S | 851 | $102.20 | Sale −$86,972 | 289,569 | Yes | Form 4 |
| Goldsmith Mark ASee Remarks | Mar 2 | Mar 3 | S | 100 | $98.31 | Sale −$9,831 | 67,324 | Yes | Form 4 |
| Goldsmith Mark ASee Remarks | Mar 2 | Mar 3 | S | 400 | $100.12 | Sale −$40,048 | 66,924 | Yes | Form 4 |
| Goldsmith Mark ASee Remarks | Mar 2 | Mar 3 | S | 1,700 | $101.47 | Sale −$172,499 | 65,224 | Yes | Form 4 |
| Goldsmith Mark ASee Remarks | Mar 2 | Mar 3 | S | 800 | $102.00 | Sale −$81,600 | 64,424 | Yes | Form 4 |
| Goldsmith Mark ASee Remarks | Mar 2 | Mar 3 | S | 100 | $98.29 | Sale −$9,829 | 67,324 | Yes | Form 4 |
| Goldsmith Mark ASee Remarks | Mar 2 | Mar 3 | S | 600 | $100.19 | Sale −$60,114 | 66,724 | Yes | Form 4 |
| Goldsmith Mark ASee Remarks | Mar 2 | Mar 3 | S | 2,100 | $101.63 | Sale −$213,423 | 64,624 | Yes | Form 4 |
| Goldsmith Mark ASee Remarks | Mar 2 | Mar 3 | S | 200 | $102.08 | Sale −$20,416 | 64,424 | Yes | Form 4 |
| Goldsmith Mark ASee Remarks | Mar 2 | Mar 3 | M · derivative | 30,000 | $4.09 | $122,700 | 47,708 | Yes | Form 4 |
| Anders JackChief Financial Officer | Mar 1 | Mar 3 | A | 20,200 | $0.00 | $0 | 128,265 | No | Form 4 |
| Anders JackChief Financial Officer | Mar 1 | Mar 3 | A · derivative | 45,400 | $102.02 | $4,631,708 | 45,400 | No | Form 4 |
| Cislini JeffGeneral Counsel | Mar 1 | Mar 3 | A | 14,500 | $0.00 | $0 | 61,476 | No | Form 4 |
| Cislini JeffGeneral Counsel | Mar 1 | Mar 3 | A · derivative | 32,500 | $102.02 | $3,315,650 | 32,500 | No | Form 4 |
| Horn Margaret AChief Operating Officer | Mar 1 | Mar 3 | A | 21,100 | $0.00 | $0 | 162,153 | No | Form 4 |
| Horn Margaret AChief Operating Officer | Mar 1 | Mar 3 | A · derivative | 47,600 | $102.02 | $4,856,152 | 47,600 | No | Form 4 |
| Goldsmith Mark ASee Remarks | Mar 1 | Mar 3 | A | 57,100 | $0.00 | $0 | 289,569 | Yes | Form 4 |
| Goldsmith Mark ASee Remarks | Mar 1 | Mar 3 | A · derivative | 128,600 | $102.02 | $13,119,772 | 128,600 | Yes | Form 4 |
| Kelsey Stephen MichaelSee Remarks | Mar 1 | Mar 3 | A | 21,100 | $0.00 | $0 | 299,700 | No | Form 4 |
| Kelsey Stephen MichaelSee Remarks | Mar 1 | Mar 3 | A · derivative | 47,600 | $102.02 | $4,856,152 | 47,600 | No | Form 4 |
| Wei LinChief Medical Officer | Mar 1 | Mar 3 | A | 15,100 | $0.00 | $0 | 103,439 | No | Form 4 |
| Wei LinChief Medical Officer | Mar 1 | Mar 3 | A · derivative | 34,000 | $102.02 | $3,468,680 | 34,000 | No | Form 4 |
| Wang XiaolinSee Remarks | Mar 1 | Mar 3 | A | 15,100 | $0.00 | $0 | 118,073 | No | Form 4 |
| Wang XiaolinSee Remarks | Mar 1 | Mar 3 | A · derivative | 34,000 | $102.02 | $3,468,680 | 34,000 | No | Form 4 |
| Goldsmith Mark ASee Remarks | Feb 6 | Feb 10 | M | 24,010 | $0.54 | $12,965 | 256,479 | No | Form 4 |
| Goldsmith Mark ASee Remarks | Feb 6 | Feb 10 | M · derivative | 24,010 | $0.54 | $12,965 | 144,493 | No | Form 4 |
| Cislini JeffGeneral Counsel | Jan 21 | Jan 23 | S | 908 | $115.60 | Sale −$104,965 | 46,976 | Yes | Form 4 |
| Anders JackChief Financial Officer | Jan 7 | Jan 9 | M | 10,000 | $42.45 | $424,500 | 118,065 | Yes | Form 4 |
| Anders JackChief Financial Officer | Jan 7 | Jan 9 | S | 10,000 | $98.00 | Sale −$980,000 | 108,065 | Yes | Form 4 |
| Anders JackChief Financial Officer | Jan 7 | Jan 9 | M · derivative | 10,000 | $42.45 | $424,500 | 15,900 | Yes | Form 4 |
| Horn Margaret AChief Operating Officer | Jan 7 | Jan 9 | M | 51,406 | $42.45 | $2,182,185 | 192,459 | Yes | Form 4 |
| Horn Margaret AChief Operating Officer | Jan 7 | Jan 9 | M | 23,594 | $29.80 | $703,101 | 216,053 | Yes | Form 4 |
| Horn Margaret AChief Operating Officer | Jan 7 | Jan 9 | S | 53,096 | $100.02 | Sale −$5,310,662 | 162,957 | Yes | Form 4 |
| Horn Margaret AChief Operating Officer | Jan 7 | Jan 9 | S | 20,204 | $101.79 | Sale −$2,056,565 | 142,753 | Yes | Form 4 |
| Horn Margaret AChief Operating Officer | Jan 7 | Jan 9 | S | 1,700 | $102.90 | Sale −$174,930 | 141,053 | Yes | Form 4 |
| Horn Margaret AChief Operating Officer | Jan 7 | Jan 9 | M · derivative | 51,406 | $42.45 | $2,182,185 | 1,094 | Yes | Form 4 |
| Horn Margaret AChief Operating Officer | Jan 7 | Jan 9 | M · derivative | 23,594 | $29.80 | $703,101 | 119,906 | Yes | Form 4 |
| Anders JackChief Financial Officer | Dec 16, 2025 | Dec 18, 2025 | S | 3,104 | $77.09 | Sale −$239,287 | 108,065 | Yes | Form 4 |
| Horn Margaret AChief Operating Officer | Dec 16, 2025 | Dec 18, 2025 | S | 4,847 | $76.82 | Sale −$372,347 | 141,053 | Yes | Form 4 |
| Kelsey Stephen MichaelSee Remarks | Dec 16, 2025 | Dec 18, 2025 | S | 5,447 | $76.82 | Sale −$418,439 | 278,600 | Yes | Form 4 |
| Goldsmith Mark ASee Remarks | Dec 16, 2025 | Dec 18, 2025 | S | 15,394 | $76.82 | Sale −$1,182,567 | 232,469 | Yes | Form 4 |
| Cislini JeffGeneral Counsel | Dec 16, 2025 | Dec 18, 2025 | S | 2,688 | $76.82 | Sale −$206,492 | 47,884 | Yes | Form 4 |
| Goldsmith Mark ASee Remarks | Nov 25, 2025 | Nov 26, 2025 | M | 60,000 | $4.09 | $245,400 | 307,863 | Yes | Form 4 |
| Goldsmith Mark ASee Remarks | Nov 25, 2025 | Nov 26, 2025 | S | 60,000 | $75.08 | Sale −$4,504,800 | 247,863 | Yes | Form 4 |
| Goldsmith Mark ASee Remarks | Nov 25, 2025 | Nov 26, 2025 | S | 3,000 | $75.00 | Sale −$225,000 | 67,424 | Yes | Form 4 |
| Goldsmith Mark ASee Remarks | Nov 25, 2025 | Nov 26, 2025 | S | 3,000 | $75.00 | Sale −$225,000 | 67,424 | Yes | Form 4 |
| Goldsmith Mark ASee Remarks | Nov 25, 2025 | Nov 26, 2025 | M · derivative | 60,000 | $4.09 | $245,400 | 77,708 | Yes | Form 4 |
| Anders JackChief Financial Officer | Nov 25, 2025 | Nov 26, 2025 | M | 5,418 | $17.00 | $92,106 | 116,412 | Yes | Form 4 |
| Anders JackChief Financial Officer | Nov 25, 2025 | Nov 26, 2025 | S | 5,418 | $74.00 | Sale −$400,932 | 110,994 | Yes | Form 4 |
| Anders JackChief Financial Officer | Nov 25, 2025 | Nov 26, 2025 | M · derivative | 5,418 | $17.00 | $92,106 | not reported | Yes | Form 4 |
| Cislini JeffGeneral Counsel | Nov 18, 2025 | Nov 20, 2025 | M | 13,388 | $42.45 | $568,321 | 63,813 | Yes | Form 4 |
| Cislini JeffGeneral Counsel | Nov 18, 2025 | Nov 20, 2025 | S | 13,388 | $70.14 | Sale −$939,034 | 50,425 | Yes | Form 4 |
| Cislini JeffGeneral Counsel | Nov 18, 2025 | Nov 20, 2025 | M · derivative | 13,388 | $42.45 | $568,321 | not reported | Yes | Form 4 |
| Goldsmith Mark ASee Remarks | Nov 18, 2025 | Nov 20, 2025 | M | 20,000 | $4.09 | $81,800 | 267,863 | Yes | Form 4 |
| Goldsmith Mark ASee Remarks | Nov 18, 2025 | Nov 20, 2025 | S | 20,000 | $70.38 | Sale −$1,407,600 | 247,863 | Yes | Form 4 |
| Goldsmith Mark ASee Remarks | Nov 18, 2025 | Nov 20, 2025 | M · derivative | 20,000 | $4.09 | $81,800 | 137,708 | Yes | Form 4 |
| Goldsmith Mark ASee Remarks | Nov 12, 2025 | Nov 14, 2025 | M | 20,000 | $4.09 | $81,800 | 267,863 | Yes | Form 4 |
| Goldsmith Mark ASee Remarks | Nov 12, 2025 | Nov 14, 2025 | S | 20,000 | $65.07 | Sale −$1,301,400 | 247,863 | Yes | Form 4 |
| Goldsmith Mark ASee Remarks | Nov 12, 2025 | Nov 14, 2025 | M · derivative | 20,000 | $4.09 | $81,800 | 157,708 | Yes | Form 4 |
| Anders JackChief Financial Officer | Nov 11, 2025 | Nov 13, 2025 | M | 10,000 | $17.00 | $170,000 | 120,994 | Yes | Form 4 |
| Anders JackChief Financial Officer | Nov 11, 2025 | Nov 13, 2025 | S | 10,000 | $64.00 | Sale −$640,000 | 110,994 | Yes | Form 4 |
| Anders JackChief Financial Officer | Nov 11, 2025 | Nov 13, 2025 | M · derivative | 10,000 | $17.00 | $170,000 | 5,418 | Yes | Form 4 |
| Goldsmith Mark ASee Remarks | Nov 12, 2025 | Nov 12, 2025 | G | 50,000 | $0.00 | $0 | 297,863 | Yes | Form 4 |
| Goldsmith Mark ASee Remarks | Nov 12, 2025 | Nov 12, 2025 | G | 50,000 | $0.00 | $0 | 247,863 | Yes | Form 4 |
| Goldsmith Mark ASee Remarks | Nov 12, 2025 | Nov 12, 2025 | G | 50,000 | $0.00 | $0 | 70,424 | Yes | Form 4 |
| Goldsmith Mark ASee Remarks | Nov 12, 2025 | Nov 12, 2025 | G | 50,000 | $0.00 | $0 | 54,498 | Yes | Form 4 |
| Goldsmith Mark ASee Remarks | Nov 7, 2025 | Nov 12, 2025 | M | 26,479 | $1.12 | $29,656 | 374,342 | Yes | Form 4 |
| Goldsmith Mark ASee Remarks | Nov 7, 2025 | Nov 12, 2025 | M | 3,521 | $4.09 | $14,401 | 377,863 | Yes | Form 4 |
| Goldsmith Mark ASee Remarks | Nov 7, 2025 | Nov 12, 2025 | S | 30,000 | $60.31 | Sale −$1,809,300 | 347,863 | Yes | Form 4 |
| Goldsmith Mark ASee Remarks | Nov 7, 2025 | Nov 12, 2025 | M · derivative | 26,479 | $1.12 | $29,656 | not reported | Yes | Form 4 |
| Goldsmith Mark ASee Remarks | Nov 7, 2025 | Nov 12, 2025 | M · derivative | 3,521 | $4.09 | $14,401 | 177,708 | Yes | Form 4 |
| Goldsmith Mark ASee Remarks | Oct 17, 2025 | Oct 20, 2025 | M | 10,000 | $1.12 | $11,200 | 462,309 | Yes | Form 4 |
| Goldsmith Mark ASee Remarks | Oct 17, 2025 | Oct 20, 2025 | S | 10,000 | $55.00 | Sale −$550,000 | 452,309 | Yes | Form 4 |
| Goldsmith Mark ASee Remarks | Oct 17, 2025 | Oct 20, 2025 | M · derivative | 10,000 | $1.12 | $11,200 | 26,479 | Yes | Form 4 |
| Cislini JeffGeneral Counsel | Oct 17, 2025 | Oct 20, 2025 | M | 12,000 | $36.57 | $438,840 | 62,425 | Yes | Form 4 |
| Cislini JeffGeneral Counsel | Oct 17, 2025 | Oct 20, 2025 | S | 12,000 | $55.00 | Sale −$660,000 | 50,425 | Yes | Form 4 |
| Cislini JeffGeneral Counsel | Oct 17, 2025 | Oct 20, 2025 | M · derivative | 12,000 | $36.57 | $438,840 | 18,000 | Yes | Form 4 |
| Goldsmith Mark ASee Remarks | Oct 16, 2025 | Oct 20, 2025 | M | 10,000 | $1.12 | $11,200 | 462,309 | Yes | Form 4 |
| Goldsmith Mark ASee Remarks | Oct 16, 2025 | Oct 20, 2025 | S | 10,000 | $50.47 | Sale −$504,700 | 452,309 | Yes | Form 4 |
| Goldsmith Mark ASee Remarks | Oct 16, 2025 | Oct 20, 2025 | M · derivative | 10,000 | $1.12 | $11,200 | 36,479 | Yes | Form 4 |
| Kelsey Stephen MichaelSee Remarks | Oct 13, 2025 | Oct 15, 2025 | M | 25,000 | $4.73 | $118,250 | 309,047 | Yes | Form 4 |
| Kelsey Stephen MichaelSee Remarks | Oct 13, 2025 | Oct 15, 2025 | S | 25,000 | $48.54 | Sale −$1,213,500 | 284,047 | Yes | Form 4 |
| Kelsey Stephen MichaelSee Remarks | Oct 13, 2025 | Oct 15, 2025 | M · derivative | 25,000 | $4.73 | $118,250 | 5,055 | Yes | Form 4 |
| Cislini JeffGeneral Counsel | Sep 24, 2025 | Sep 26, 2025 | S | 1,799 | $44.26 | Sale −$79,624 | 50,425 | Yes | Form 4 |
| Anders JackChief Financial Officer | Sep 16, 2025 | Sep 18, 2025 | S | 2,320 | $45.82 | Sale −$106,302 | 110,994 | Yes | Form 4 |
| Cislini JeffGeneral Counsel | Sep 16, 2025 | Sep 18, 2025 | S | 1,869 | $45.82 | Sale −$85,638 | 52,224 | Yes | Form 4 |
| Horn Margaret AChief Operating Officer | Sep 16, 2025 | Sep 18, 2025 | S | 4,775 | $45.82 | Sale −$218,791 | 145,900 | Yes | Form 4 |
| Goldsmith Mark ASee Remarks | Sep 16, 2025 | Sep 18, 2025 | S | 13,411 | $45.82 | Sale −$614,492 | 452,309 | Yes | Form 4 |
| Kelsey Stephen MichaelSee Remarks | Sep 16, 2025 | Sep 18, 2025 | S | 5,367 | $45.82 | Sale −$245,916 | 284,047 | Yes | Form 4 |
| Wei LinChief Medical Officer | Sep 16, 2025 | Sep 18, 2025 | S | 2,160 | $45.82 | Sale −$98,971 | 88,339 | Yes | Form 4 |
| Kelsey Stephen MichaelSee Remarks | Sep 15, 2025 | Sep 15, 2025 | M | 25,000 | $4.73 | $118,250 | 314,414 | Yes | Form 4 |
| Kelsey Stephen MichaelSee Remarks | Sep 15, 2025 | Sep 15, 2025 | S | 23,682 | $45.92 | Sale −$1,087,477 | 290,732 | Yes | Form 4 |
| Kelsey Stephen MichaelSee Remarks | Sep 15, 2025 | Sep 15, 2025 | S | 1,318 | $46.93 | Sale −$61,854 | 289,414 | Yes | Form 4 |
| Kelsey Stephen MichaelSee Remarks | Sep 15, 2025 | Sep 15, 2025 | M · derivative | 25,000 | $4.73 | $118,250 | 30,055 | Yes | Form 4 |
| Kelsey Stephen MichaelSee Remarks | Sep 11, 2025 | Sep 15, 2025 | M | 100,000 | $4.73 | $473,000 | 389,414 | Yes | Form 4 |
| Kelsey Stephen MichaelSee Remarks | Sep 11, 2025 | Sep 15, 2025 | S | 44,059 | $43.58 | Sale −$1,920,091 | 345,355 | Yes | Form 4 |
| Kelsey Stephen MichaelSee Remarks | Sep 11, 2025 | Sep 15, 2025 | S | 55,941 | $44.48 | Sale −$2,488,256 | 289,414 | Yes | Form 4 |
| Kelsey Stephen MichaelSee Remarks | Sep 11, 2025 | Sep 15, 2025 | M · derivative | 100,000 | $4.73 | $473,000 | 55,055 | Yes | Form 4 |
| Anders JackChief Financial Officer | Sep 3, 2025 | Sep 4, 2025 | M | 3,189 | $4.73 | $15,084 | 116,503 | Yes | Form 4 |
| Anders JackChief Financial Officer | Sep 3, 2025 | Sep 4, 2025 | M | 2,049 | $17.00 | $34,833 | 118,552 | Yes | Form 4 |
| Anders JackChief Financial Officer | Sep 3, 2025 | Sep 4, 2025 | S | 5,238 | $40.17 | Sale −$210,410 | 113,314 | Yes | Form 4 |
| Anders JackChief Financial Officer | Sep 3, 2025 | Sep 4, 2025 | M · derivative | 3,189 | $4.73 | $15,084 | not reported | Yes | Form 4 |
| Anders JackChief Financial Officer | Sep 3, 2025 | Sep 4, 2025 | M · derivative | 2,049 | $17.00 | $34,833 | 15,418 | Yes | Form 4 |
| Anders JackChief Financial Officer | Sep 2, 2025 | Sep 4, 2025 | M | 2,814 | $2.68 | $7,542 | 116,128 | Yes | Form 4 |
| Anders JackChief Financial Officer | Sep 2, 2025 | Sep 4, 2025 | M | 1,948 | $4.73 | $9,214 | 118,076 | Yes | Form 4 |
| Anders JackChief Financial Officer | Sep 2, 2025 | Sep 4, 2025 | S | 4,762 | $40.02 | Sale −$190,575 | 113,314 | Yes | Form 4 |
| Anders JackChief Financial Officer | Sep 2, 2025 | Sep 4, 2025 | M · derivative | 2,814 | $2.68 | $7,542 | not reported | Yes | Form 4 |
| Anders JackChief Financial Officer | Sep 2, 2025 | Sep 4, 2025 | M · derivative | 1,948 | $4.73 | $9,214 | 3,189 | Yes | Form 4 |
| Goldsmith Mark ASee Remarks | Jun 30, 2025 | Jul 2, 2025 | M | 37,000 | $0.54 | $19,980 | 465,720 | No | Form 4 |
| Goldsmith Mark ASee Remarks | Jun 30, 2025 | Jul 2, 2025 | M · derivative | 37,000 | $0.54 | $19,980 | 168,503 | No | Form 4 |
| Clyburn Frank | Jun 26, 2025 | Jun 30, 2025 | A | 2,806 | $0.00 | $0 | 9,738 | No | Form 4 |
| Clyburn Frank | Jun 26, 2025 | Jun 30, 2025 | A · derivative | 10,337 | $37.48 | $387,431 | 10,337 | No | Form 4 |
| Anderson Elizabeth M | Jun 26, 2025 | Jun 30, 2025 | A | 3,142 | $0.00 | $0 | 23,215 | No | Form 4 |
| Anderson Elizabeth M | Jun 26, 2025 | Jun 30, 2025 | A · derivative | 11,574 | $37.48 | $433,794 | 11,574 | No | Form 4 |
| Borellini Flavia | Jun 26, 2025 | Jun 30, 2025 | A | 3,142 | $0.00 | $0 | 25,024 | No | Form 4 |
| Borellini Flavia | Jun 26, 2025 | Jun 30, 2025 | A · derivative | 11,574 | $37.48 | $433,794 | 11,574 | No | Form 4 |
| Borisy Alexis | Jun 26, 2025 | Jun 30, 2025 | A | 3,142 | $0.00 | $0 | 2,338,884 | No | Form 4 |
| Borisy Alexis | Jun 26, 2025 | Jun 30, 2025 | A · derivative | 11,574 | $37.48 | $433,794 | 11,574 | No | Form 4 |
| Kim Lorence H. | Jun 26, 2025 | Jun 30, 2025 | A | 3,142 | $0.00 | $0 | 73,090 | No | Form 4 |
| Kim Lorence H. | Jun 26, 2025 | Jun 30, 2025 | A · derivative | 11,574 | $37.48 | $433,794 | 11,574 | No | Form 4 |
| Patel Sushil | Jun 26, 2025 | Jun 30, 2025 | A | 3,142 | $0.00 | $0 | 23,090 | No | Form 4 |
| Patel Sushil | Jun 26, 2025 | Jun 30, 2025 | A · derivative | 11,574 | $37.48 | $433,794 | 11,574 | No | Form 4 |
| Horning Sandra | Jun 26, 2025 | Jun 30, 2025 | A | 3,142 | $0.00 | $0 | 96,574 | No | Form 4 |
| Horning Sandra | Jun 26, 2025 | Jun 30, 2025 | A · derivative | 11,574 | $37.48 | $433,794 | 11,574 | No | Form 4 |
| Cislini JeffGeneral Counsel | Jun 20, 2025 | Jun 23, 2025 | S | 1,912 | $39.61 | Sale −$75,734 | 54,093 | Yes | Form 4 |
| Wei LinChief Medical Officer | Jun 16, 2025 | Jun 18, 2025 | S | 2,173 | $39.83 | Sale −$86,551 | 90,499 | Yes | Form 4 |
| Kelsey Stephen MichaelSee Remarks | Jun 16, 2025 | Jun 18, 2025 | S | 4,289 | $39.83 | Sale −$170,831 | 289,414 | Yes | Form 4 |
| Anders JackChief Financial Officer | Jun 16, 2025 | Jun 18, 2025 | S | 2,170 | $39.83 | Sale −$86,431 | 113,314 | Yes | Form 4 |
| Cislini JeffGeneral Counsel | Jun 16, 2025 | Jun 18, 2025 | S | 1,878 | $39.83 | Sale −$74,801 | 56,005 | Yes | Form 4 |
| Goldsmith Mark ASee Remarks | Jun 16, 2025 | Jun 18, 2025 | S | 13,496 | $39.83 | Sale −$537,546 | 428,720 | Yes | Form 4 |
| Horn Margaret AChief Operating Officer | Jun 16, 2025 | Jun 18, 2025 | S | 3,510 | $39.83 | Sale −$139,803 | 150,675 | Yes | Form 4 |
| Clyburn Frank | Aug 5, 2024 | Apr 28, 20254/A | A · derivative | 26,540 | $42.48 | $1,127,419 | 26,540 | No | Form 4/A |
| Cislini JeffGeneral Counsel | Mar 20, 2025 | Mar 24, 2025 | S | 2,041 | $38.71 | Sale −$79,007 | 57,723 | Yes | Form 4 |
| Wang XiaolinSee Remarks | Mar 17, 2025 | Mar 19, 2025 | G | 2,718 | $0.00 | $0 | 102,321 | No | Form 4 |
| Kelsey Stephen MichaelSee Remarks | Mar 17, 2025 | Mar 19, 2025 | S | 3,294 | $39.04 | Sale −$128,598 | 293,051 | Yes | Form 4 |
| Horn Margaret AChief Operating Officer | Mar 17, 2025 | Mar 19, 2025 | S | 3,058 | $39.04 | Sale −$119,384 | 153,533 | Yes | Form 4 |
| Anders JackChief Financial Officer | Mar 17, 2025 | Mar 19, 2025 | S | 1,864 | $39.04 | Sale −$72,771 | 115,006 | Yes | Form 4 |
| Goldsmith Mark ASee Remarks | Mar 17, 2025 | Mar 19, 2025 | S | 11,738 | $39.04 | Sale −$458,252 | 441,564 | Yes | Form 4 |
| Cislini JeffGeneral Counsel | Mar 17, 2025 | Mar 19, 2025 | S | 1,458 | $39.04 | Sale −$56,920 | 59,764 | Yes | Form 4 |
| Goldsmith Mark ASee Remarks | Mar 1, 2025 | Mar 4, 2025 | A | 97,400 | $0.00 | $0 | 453,302 | No | Form 4 |
| Goldsmith Mark ASee Remarks | Mar 1, 2025 | Mar 4, 2025 | A · derivative | 341,100 | $40.74 | $13,896,414 | not reported | No | Form 4 |
| Wang XiaolinSee Remarks | Mar 1, 2025 | Mar 4, 2025 | A | 19,000 | $0.00 | $0 | 105,039 | No | Form 4 |
| Wang XiaolinSee Remarks | Mar 1, 2025 | Mar 4, 2025 | A · derivative | 66,500 | $40.74 | $2,709,210 | 66,500 | No | Form 4 |
| Wei LinChief Medical Officer | Mar 1, 2025 | Mar 4, 2025 | A | 20,800 | $0.00 | $0 | 91,651 | No | Form 4 |
| Wei LinChief Medical Officer | Mar 1, 2025 | Mar 4, 2025 | A · derivative | 72,800 | $40.74 | $2,965,872 | 72,800 | No | Form 4 |
| Horn Margaret AChief Operating Officer | Mar 1, 2025 | Mar 4, 2025 | A | 28,600 | $0.00 | $0 | 156,591 | No | Form 4 |
| Horn Margaret AChief Operating Officer | Mar 1, 2025 | Mar 4, 2025 | A · derivative | 100,100 | $40.74 | $4,078,074 | 100,100 | No | Form 4 |
| Kelsey Stephen MichaelSee Remarks | Mar 1, 2025 | Mar 4, 2025 | A | 36,600 | $0.00 | $0 | 296,345 | No | Form 4 |
| Kelsey Stephen MichaelSee Remarks | Mar 1, 2025 | Mar 4, 2025 | A · derivative | 128,100 | $40.74 | $5,218,794 | 128,100 | No | Form 4 |
| Anders JackChief Financial Officer | Mar 1, 2025 | Mar 4, 2025 | A | 20,400 | $0.00 | $0 | 116,870 | No | Form 4 |
| Anders JackChief Financial Officer | Mar 1, 2025 | Mar 4, 2025 | A · derivative | 71,400 | $40.74 | $2,908,836 | 71,400 | No | Form 4 |
| Cislini JeffGeneral Counsel | Mar 1, 2025 | Mar 4, 2025 | A | 22,000 | $0.00 | $0 | 61,222 | No | Form 4 |
| Cislini JeffGeneral Counsel | Mar 1, 2025 | Mar 4, 2025 | A · derivative | 77,000 | $40.74 | $3,136,980 | 77,000 | No | Form 4 |
| Cislini JeffGeneral Counsel | Jan 21, 2025 | Jan 22, 2025 | S | 2,406 | $40.50 | Sale −$97,443 | 39,222 | Yes | Form 4 |
| Goldsmith Mark ASee Remarks | Dec 18, 2024 | Dec 20, 2024 | M | 30,846 | $0.49 | $15,115 | 355,902 | No | Form 4 |
| Goldsmith Mark ASee Remarks | Dec 18, 2024 | Dec 20, 2024 | M · derivative | 30,846 | $0.49 | $15,115 | not reported | No | Form 4 |
| Anders JackChief Financial Officer | Dec 16, 2024 | Dec 18, 2024 | S | 2,635 | $45.40 | Sale −$119,629 | 96,470 | Yes | Form 4 |
| Cislini JeffGeneral Counsel | Dec 16, 2024 | Dec 18, 2024 | S | 1,599 | $45.40 | Sale −$72,595 | 41,628 | Yes | Form 4 |
| Kelsey Stephen MichaelSee Remarks | Dec 16, 2024 | Dec 18, 2024 | S | 4,663 | $45.40 | Sale −$211,700 | 259,745 | Yes | Form 4 |
| Goldsmith Mark ASee Remarks | Dec 16, 2024 | Dec 18, 2024 | S | 11,714 | $45.40 | Sale −$531,816 | 325,056 | Yes | Form 4 |
| Horn Margaret AChief Operating Officer | Dec 16, 2024 | Dec 18, 2024 | S | 4,329 | $45.40 | Sale −$196,537 | 127,991 | Yes | Form 4 |
| Schroeder Thilo | Dec 5, 2024 | Dec 9, 2024 | P | 543,478 | $46.00 | Purchase +$24,999,988 | 2,096,612 | No | Form 4 |
| Schroeder Thilo | Dec 5, 2024 | Dec 9, 2024 | P | 760,869 | $46.00 | Purchase +$34,999,974 | 760,869 | No | Form 4 |
| Cislini JeffGeneral Counsel | Nov 15, 2024 | Nov 19, 2024 | S | 2,554 | $55.13 | Sale −$140,802 | 43,080 | Yes | Form 4 |
| Kelsey Stephen MichaelSee Remarks | Nov 13, 2024 | Nov 15, 2024 | M | 16,666 | $4.09 | $68,164 | 281,074 | Yes | Form 4 |
| Kelsey Stephen MichaelSee Remarks | Nov 13, 2024 | Nov 15, 2024 | S | 13,778 | $58.49 | Sale −$805,875 | 267,296 | Yes | Form 4 |
| Kelsey Stephen MichaelSee Remarks | Nov 13, 2024 | Nov 15, 2024 | S | 2,888 | $59.45 | Sale −$171,692 | 264,408 | Yes | Form 4 |
| Kelsey Stephen MichaelSee Remarks | Nov 13, 2024 | Nov 15, 2024 | M · derivative | 16,666 | $4.09 | $68,164 | 6,666 | Yes | Form 4 |
| Cislini JeffGeneral Counsel | Nov 6, 2024 | Nov 8, 2024 | M | 6,000 | $36.57 | $219,420 | 51,634 | Yes | Form 4 |
| Cislini JeffGeneral Counsel | Nov 6, 2024 | Nov 8, 2024 | S | 6,000 | $60.00 | Sale −$360,000 | 45,634 | Yes | Form 4 |
| Cislini JeffGeneral Counsel | Nov 6, 2024 | Nov 8, 2024 | M · derivative | 6,000 | $36.57 | $219,420 | 30,000 | Yes | Form 4 |
| Goldsmith Mark ASee Remarks | Nov 4, 2024 | Nov 5, 2024 | M | 50,900 | $4.09 | $208,181 | 351,070 | Yes | Form 4 |
| Goldsmith Mark ASee Remarks | Nov 4, 2024 | Nov 5, 2024 | S | 50,900 | $55.56 | Sale −$2,828,004 | 300,170 | Yes | Form 4 |
| Goldsmith Mark ASee Remarks | Nov 4, 2024 | Nov 5, 2024 | M | 36,600 | $0.49 | $17,934 | 336,770 | Yes | Form 4 |
| Goldsmith Mark ASee Remarks | Nov 4, 2024 | Nov 5, 2024 | M · derivative | 50,900 | $4.09 | $208,181 | 181,229 | Yes | Form 4 |
| Goldsmith Mark ASee Remarks | Nov 4, 2024 | Nov 5, 2024 | M · derivative | 36,600 | $0.49 | $17,934 | 30,846 | Yes | Form 4 |
| Goldsmith Mark ASee Remarks | Nov 1, 2024 | Nov 5, 2024 | M | 9,100 | $4.09 | $37,219 | 309,270 | Yes | Form 4 |
| Goldsmith Mark ASee Remarks | Nov 1, 2024 | Nov 5, 2024 | S | 9,100 | $55.02 | Sale −$500,682 | 300,170 | Yes | Form 4 |
| Goldsmith Mark ASee Remarks | Nov 1, 2024 | Nov 5, 2024 | S | 5,000 | $55.03 | Sale −$275,150 | 20,424 | Yes | Form 4 |
| Goldsmith Mark ASee Remarks | Nov 1, 2024 | Nov 5, 2024 | S | 5,000 | $55.02 | Sale −$275,100 | 20,424 | Yes | Form 4 |
| Goldsmith Mark ASee Remarks | Nov 1, 2024 | Nov 5, 2024 | M · derivative | 9,100 | $4.09 | $37,219 | 232,129 | Yes | Form 4 |
| Patel Sushil | Oct 31, 2024 | Nov 4, 2024 | M | 5,000 | $24.84 | $124,200 | 24,948 | Yes | Form 4 |
| Patel Sushil | Oct 31, 2024 | Nov 4, 2024 | S | 5,000 | $54.14 | Sale −$270,700 | 19,948 | Yes | Form 4 |
| Patel Sushil | Oct 31, 2024 | Nov 4, 2024 | M · derivative | 5,000 | $24.84 | $124,200 | 13,400 | Yes | Form 4 |
| Kelsey Stephen MichaelSee Remarks | Oct 14, 2024 | Oct 16, 2024 | M | 16,666 | $4.09 | $68,164 | 281,074 | Yes | Form 4 |
| Kelsey Stephen MichaelSee Remarks | Oct 14, 2024 | Oct 16, 2024 | S | 14,056 | $49.38 | Sale −$694,085 | 267,018 | Yes | Form 4 |
| Kelsey Stephen MichaelSee Remarks | Oct 14, 2024 | Oct 16, 2024 | S | 2,610 | $50.08 | Sale −$130,709 | 264,408 | Yes | Form 4 |
| Kelsey Stephen MichaelSee Remarks | Oct 14, 2024 | Oct 16, 2024 | M · derivative | 16,666 | $4.09 | $68,164 | 23,332 | Yes | Form 4 |
| Cislini JeffGeneral Counsel | Oct 11, 2024 | Oct 15, 2024 | M | 6,000 | $36.57 | $219,420 | 51,634 | Yes | Form 4 |
| Cislini JeffGeneral Counsel | Oct 11, 2024 | Oct 15, 2024 | S | 6,000 | $50.17 | Sale −$301,020 | 45,634 | Yes | Form 4 |
| Cislini JeffGeneral Counsel | Oct 11, 2024 | Oct 15, 2024 | M · derivative | 6,000 | $36.57 | $219,420 | 36,000 | Yes | Form 4 |
| Anders JackChief Financial Officer | Oct 11, 2024 | Oct 15, 2024 | M | 10,000 | $2.68 | $26,800 | 108,932 | Yes | Form 4 |
| Anders JackChief Financial Officer | Oct 11, 2024 | Oct 15, 2024 | S | 10,000 | $50.30 | Sale −$503,000 | 98,932 | Yes | Form 4 |
| Anders JackChief Financial Officer | Oct 11, 2024 | Oct 15, 2024 | M · derivative | 10,000 | $2.68 | $26,800 | 2,814 | Yes | Form 4 |
| Goldsmith Mark ASee Remarks | Oct 11, 2024 | Oct 15, 2024 | M | 30,000 | $4.09 | $122,700 | 330,170 | Yes | Form 4 |
| Goldsmith Mark ASee Remarks | Oct 11, 2024 | Oct 15, 2024 | S | 30,000 | $50.36 | Sale −$1,510,800 | 300,170 | Yes | Form 4 |
| Goldsmith Mark ASee Remarks | Oct 11, 2024 | Oct 15, 2024 | M · derivative | 30,000 | $4.09 | $122,700 | 241,229 | Yes | Form 4 |
| Horn Margaret AChief Operating Officer | Oct 11, 2024 | Oct 15, 2024 | M | 44,631 | $4.09 | $182,541 | 176,951 | Yes | Form 4 |
| Horn Margaret AChief Operating Officer | Oct 11, 2024 | Oct 15, 2024 | M | 5,369 | $4.09 | $21,959 | 182,320 | Yes | Form 4 |
| Horn Margaret AChief Operating Officer | Oct 11, 2024 | Oct 15, 2024 | S | 50,000 | $50.34 | Sale −$2,517,000 | 132,320 | Yes | Form 4 |
| Horn Margaret AChief Operating Officer | Oct 11, 2024 | Oct 15, 2024 | M · derivative | 44,631 | $4.09 | $182,541 | not reported | Yes | Form 4 |
| Horn Margaret AChief Operating Officer | Oct 11, 2024 | Oct 15, 2024 | M · derivative | 5,369 | $4.09 | $21,959 | 97,382 | Yes | Form 4 |
| Weber Barbara | Oct 8, 2024 | Oct 10, 2024 | S | 5,200 | $48.02 | Sale −$249,704 | 13,065 | Yes | Form 4 |
| Goldsmith Mark ASee Remarks | Oct 1, 2024 | Oct 3, 2024 | M | 10,000 | $4.09 | $40,900 | 310,170 | Yes | Form 4 |
| Goldsmith Mark ASee Remarks | Oct 1, 2024 | Oct 3, 2024 | S | 7,978 | $44.80 | Sale −$357,414 | 302,192 | Yes | Form 4 |
| Goldsmith Mark ASee Remarks | Oct 1, 2024 | Oct 3, 2024 | S | 2,022 | $45.46 | Sale −$91,920 | 300,170 | Yes | Form 4 |
| Goldsmith Mark ASee Remarks | Oct 1, 2024 | Oct 3, 2024 | M · derivative | 10,000 | $4.09 | $40,900 | 271,229 | Yes | Form 4 |
| Cislini JeffGeneral Counsel | Sep 16, 2024 | Sep 18, 2024 | S | 1,454 | $44.19 | Sale −$64,252 | 45,634 | Yes | Form 4 |
| Kelsey Stephen MichaelSee Remarks | Sep 16, 2024 | Sep 18, 2024 | S | 4,665 | $44.19 | Sale −$206,146 | 264,408 | Yes | Form 4 |
| Horn Margaret AChief Operating Officer | Sep 16, 2024 | Sep 18, 2024 | S | 4,331 | $44.19 | Sale −$191,387 | 132,320 | Yes | Form 4 |
| Goldsmith Mark ASee Remarks | Sep 16, 2024 | Sep 18, 2024 | S | 11,715 | $44.19 | Sale −$517,686 | 300,170 | Yes | Form 4 |
| Anders JackChief Financial Officer | Sep 16, 2024 | Sep 18, 2024 | S | 2,244 | $44.19 | Sale −$99,162 | 98,932 | Yes | Form 4 |
| Kelsey Stephen MichaelSee Remarks | Sep 13, 2024 | Sep 16, 2024 | M | 16,667 | $4.09 | $68,168 | 285,740 | Yes | Form 4 |
| Kelsey Stephen MichaelSee Remarks | Sep 13, 2024 | Sep 16, 2024 | S | 5,966 | $42.75 | Sale −$255,047 | 279,774 | Yes | Form 4 |
| Kelsey Stephen MichaelSee Remarks | Sep 13, 2024 | Sep 16, 2024 | S | 10,701 | $43.65 | Sale −$467,099 | 269,073 | Yes | Form 4 |
| Kelsey Stephen MichaelSee Remarks | Sep 13, 2024 | Sep 16, 2024 | M · derivative | 16,667 | $4.09 | $68,168 | 39,998 | Yes | Form 4 |
| Weber Barbara | Aug 21, 2024 | Aug 23, 2024 | D | 1,808 | $44.83 | $81,053 | 18,265 | No | Form 4 |
| Kelsey Stephen MichaelSee Remarks | Aug 13, 2024 | Aug 15, 2024 | M | 16,667 | $4.09 | $68,168 | 285,740 | Yes | Form 4 |
| Kelsey Stephen MichaelSee Remarks | Aug 13, 2024 | Aug 15, 2024 | S | 16,667 | $42.98 | Sale −$716,348 | 269,073 | Yes | Form 4 |
| Kelsey Stephen MichaelSee Remarks | Aug 13, 2024 | Aug 15, 2024 | M · derivative | 16,667 | $4.09 | $68,168 | 56,665 | Yes | Form 4 |
| Goldsmith Mark ASee Remarks | Aug 1, 2024 | Aug 2, 2024 | M | 10,000 | $4.09 | $40,900 | 321,885 | Yes | Form 4 |
| Goldsmith Mark ASee Remarks | Aug 1, 2024 | Aug 2, 2024 | S | 6,783 | $45.60 | Sale −$309,305 | 315,102 | Yes | Form 4 |
| Goldsmith Mark ASee Remarks | Aug 1, 2024 | Aug 2, 2024 | S | 3,217 | $46.48 | Sale −$149,526 | 311,885 | Yes | Form 4 |
| Goldsmith Mark ASee Remarks | Aug 1, 2024 | Aug 2, 2024 | M · derivative | 10,000 | $4.09 | $40,900 | 281,229 | Yes | Form 4 |
| Kelsey Stephen MichaelSee Remarks | Jul 15, 2024 | Jul 17, 2024 | M | 16,667 | $4.09 | $68,168 | 285,740 | Yes | Form 4 |
| Kelsey Stephen MichaelSee Remarks | Jul 15, 2024 | Jul 17, 2024 | S | 1,100 | $43.99 | Sale −$48,389 | 284,640 | Yes | Form 4 |
| Kelsey Stephen MichaelSee Remarks | Jul 15, 2024 | Jul 17, 2024 | S | 2,128 | $44.94 | Sale −$95,632 | 282,512 | Yes | Form 4 |
| Kelsey Stephen MichaelSee Remarks | Jul 15, 2024 | Jul 17, 2024 | S | 5,760 | $46.08 | Sale −$265,421 | 276,752 | Yes | Form 4 |
| Kelsey Stephen MichaelSee Remarks | Jul 15, 2024 | Jul 17, 2024 | S | 3,800 | $47.02 | Sale −$178,676 | 272,952 | Yes | Form 4 |
| Kelsey Stephen MichaelSee Remarks | Jul 15, 2024 | Jul 17, 2024 | S | 3,879 | $48.06 | Sale −$186,425 | 269,073 | Yes | Form 4 |
| Kelsey Stephen MichaelSee Remarks | Jul 15, 2024 | Jul 17, 2024 | M · derivative | 16,667 | $4.09 | $68,168 | 73,332 | Yes | Form 4 |
| Goldsmith Mark ASee Remarks | Jul 12, 2024 | Jul 16, 2024 | M | 25,000 | $4.09 | $102,250 | 336,885 | Yes | Form 4 |
| Goldsmith Mark ASee Remarks | Jul 12, 2024 | Jul 16, 2024 | S | 25,000 | $45.05 | Sale −$1,126,250 | 311,885 | Yes | Form 4 |
| Goldsmith Mark ASee Remarks | Jul 12, 2024 | Jul 16, 2024 | S | 5,000 | $45.01 | Sale −$225,050 | 25,424 | Yes | Form 4 |
| Goldsmith Mark ASee Remarks | Jul 12, 2024 | Jul 16, 2024 | S | 5,000 | $45.01 | Sale −$225,050 | 25,424 | Yes | Form 4 |
| Goldsmith Mark ASee Remarks | Jul 12, 2024 | Jul 16, 2024 | M · derivative | 25,000 | $4.09 | $102,250 | 291,229 | Yes | Form 4 |
| Patel Sushil | Jul 9, 2024 | Jul 10, 2024 | M | 2,155 | $16.80 | $36,204 | 22,103 | Yes | Form 4 |
| Patel Sushil | Jul 9, 2024 | Jul 10, 2024 | S | 2,155 | $44.00 | Sale −$94,820 | 19,948 | Yes | Form 4 |
| Patel Sushil | Jul 9, 2024 | Jul 10, 2024 | M · derivative | 2,155 | $16.80 | $36,204 | 32,490 | Yes | Form 4 |
| Cislini JeffGeneral Counsel | Jul 9, 2024 | Jul 10, 2024 | S | 2,399 | $40.83 | Sale −$97,951 | 47,088 | Yes | Form 4 |
| Horning Sandra | Jun 20, 2024 | Jun 28, 20244/A | A | 2,945 | $0.00 | $0 | 93,432 | No | Form 4/A |
| Horning Sandra | Jun 20, 2024 | Jun 28, 20244/A | A · derivative | 10,248 | $37.54 | $384,710 | 10,248 | No | Form 4/A |
| Patel Sushil | Jun 20, 2024 | Jun 28, 20244/A | A | 4,248 | $0.00 | $0 | 19,948 | No | Form 4/A |
| Patel Sushil | Jun 20, 2024 | Jun 28, 20244/A | A · derivative | 15,955 | $37.54 | $598,951 | 15,955 | No | Form 4/A |
| Borisy Alexis | Jun 20, 2024 | Jun 28, 20244/A | A | 4,248 | $0.00 | $0 | 2,335,742 | No | Form 4/A |
| Borisy Alexis | Jun 20, 2024 | Jun 28, 20244/A | A · derivative | 15,955 | $37.54 | $598,951 | 15,955 | No | Form 4/A |
| Kim Lorence H. | Jun 20, 2024 | Jun 28, 20244/A | A | 4,248 | $0.00 | $0 | 69,948 | No | Form 4/A |
| Kim Lorence H. | Jun 20, 2024 | Jun 28, 20244/A | A · derivative | 15,955 | $37.54 | $598,951 | 15,955 | No | Form 4/A |
| Weber Barbara | Jun 20, 2024 | Jun 28, 20244/A | A | 4,248 | $0.00 | $0 | 20,073 | No | Form 4/A |
| Weber Barbara | Jun 20, 2024 | Jun 28, 20244/A | A · derivative | 15,955 | $37.54 | $598,951 | 15,955 | No | Form 4/A |
| Borellini Flavia | Jun 20, 2024 | Jun 28, 20244/A | A | 4,248 | $0.00 | $0 | 21,882 | No | Form 4/A |
| Borellini Flavia | Jun 20, 2024 | Jun 28, 20244/A | A · derivative | 15,955 | $37.54 | $598,951 | 15,955 | No | Form 4/A |
| Anderson Elizabeth M | Jun 20, 2024 | Jun 28, 20244/A | A | 4,248 | $0.00 | $0 | 20,073 | No | Form 4/A |
| Anderson Elizabeth M | Jun 20, 2024 | Jun 28, 20244/A | A · derivative | 15,955 | $37.54 | $598,951 | 15,955 | No | Form 4/A |
| Cislini JeffGeneral Counsel | Jun 26, 2024 | Jun 27, 2024 | S | 2,000 | $38.47 | Sale −$76,940 | 49,487 | Yes | Form 4 |
| Kelsey Stephen MichaelSee Remarks | Jun 25, 2024 | Jun 26, 2024 | M | 16,467 | $4.09 | $67,350 | 285,540 | Yes | Form 4 |
| Kelsey Stephen MichaelSee Remarks | Jun 25, 2024 | Jun 26, 2024 | S | 16,467 | $39.06 | Sale −$643,201 | 269,073 | Yes | Form 4 |
| Kelsey Stephen MichaelSee Remarks | Jun 25, 2024 | Jun 26, 2024 | M · derivative | 16,467 | $4.09 | $67,350 | 89,999 | Yes | Form 4 |
| Kelsey Stephen MichaelSee Remarks | Jun 24, 2024 | Jun 26, 2024 | M | 200 | $4.09 | $818 | 269,273 | Yes | Form 4 |
| Kelsey Stephen MichaelSee Remarks | Jun 24, 2024 | Jun 26, 2024 | S | 200 | $39.00 | Sale −$7,800 | 269,073 | Yes | Form 4 |
| Kelsey Stephen MichaelSee Remarks | Jun 24, 2024 | Jun 26, 2024 | M · derivative | 200 | $4.09 | $818 | 106,466 | Yes | Form 4 |
| Wei LinChief Medical Officer | Jun 17, 2024 | Jun 20, 2024 | S | 5,589 | $37.39 | Sale −$208,973 | 70,851 | No | Form 4 |
| Cislini JeffGeneral Counsel | Jun 17, 2024 | Jun 20, 2024 | S | 1,757 | $37.39 | Sale −$65,694 | 51,487 | Yes | Form 4 |
| Kelsey Stephen MichaelSee Remarks | Jun 17, 2024 | Jun 20, 2024 | S | 3,349 | $37.39 | Sale −$125,219 | 269,073 | Yes | Form 4 |
| Horn Margaret AChief Operating Officer | Jun 17, 2024 | Jun 20, 2024 | S | 4,415 | $37.39 | Sale −$165,077 | 136,651 | Yes | Form 4 |
| Anders JackChief Financial Officer | Jun 17, 2024 | Jun 20, 2024 | S | 1,893 | $37.39 | Sale −$70,779 | 101,176 | Yes | Form 4 |
| Goldsmith Mark ASee Remarks | Jun 17, 2024 | Jun 20, 2024 | S | 11,950 | $37.39 | Sale −$446,811 | 311,885 | Yes | Form 4 |
| Goldsmith Mark ASee Remarks | Jun 3, 2024 | Jun 5, 2024 | M | 7,500 | $4.09 | $30,675 | 329,822 | Yes | Form 4 |
| Goldsmith Mark ASee Remarks | Jun 3, 2024 | Jun 5, 2024 | S | 900 | $39.09 | Sale −$35,181 | 328,922 | Yes | Form 4 |
| Goldsmith Mark ASee Remarks | Jun 3, 2024 | Jun 5, 2024 | S | 5,699 | $39.99 | Sale −$227,903 | 323,223 | Yes | Form 4 |
| Goldsmith Mark ASee Remarks | Jun 3, 2024 | Jun 5, 2024 | S | 901 | $40.93 | Sale −$36,878 | 322,322 | Yes | Form 4 |
| Goldsmith Mark ASee Remarks | Jun 3, 2024 | Jun 5, 2024 | M · derivative | 7,500 | $4.09 | $30,675 | 316,229 | Yes | Form 4 |
| Cislini JeffGeneral Counsel | May 21, 2024 | May 22, 2024 | S | 700 | $38.67 | Sale −$27,069 | 53,674 | Yes | Form 4 |
| Cislini JeffGeneral Counsel | May 21, 2024 | May 22, 2024 | S | 800 | $39.51 | Sale −$31,608 | 52,874 | Yes | Form 4 |
| Anders JackChief Financial Officer | May 3, 2024 | May 3, 2024 | M | 10,000 | $2.68 | $26,800 | 111,959 | Yes | Form 4 |
| Anders JackChief Financial Officer | May 3, 2024 | May 3, 2024 | S | 10,000 | $40.03 | Sale −$400,300 | 101,959 | Yes | Form 4 |
| Anders JackChief Financial Officer | May 3, 2024 | May 3, 2024 | M · derivative | 10,000 | $2.68 | $26,800 | 12,814 | Yes | Form 4 |
| Patel Sushil | Apr 10, 2024 | Apr 12, 2024 | M | 2,155 | $16.80 | $36,204 | 17,855 | Yes | Form 4 |
| Patel Sushil | Apr 10, 2024 | Apr 12, 2024 | S | 2,155 | $37.00 | Sale −$79,735 | 15,700 | Yes | Form 4 |
| Patel Sushil | Apr 10, 2024 | Apr 12, 2024 | M · derivative | 2,155 | $16.80 | $36,204 | 34,645 | Yes | Form 4 |
| Goldsmith Mark ASee Remarks | Apr 10, 2024 | Apr 12, 2024 | S | 7,500 | $35.48 | Sale −$266,100 | 452,879 | Yes | Form 4 |
| Goldsmith Mark ASee Remarks | Apr 10, 2024 | Apr 12, 2024 | S | 5,000 | $35.33 | Sale −$176,650 | 30,424 | Yes | Form 4 |
| Goldsmith Mark ASee Remarks | Apr 10, 2024 | Apr 12, 2024 | S | 5,000 | $35.34 | Sale −$176,700 | 30,424 | Yes | Form 4 |
| Cislini JeffGeneral Counsel | Mar 27, 2024 | Mar 28, 2024 | S | 700 | $30.38 | Sale −$21,266 | 55,174 | Yes | Form 4 |
| Cislini JeffGeneral Counsel | Mar 27, 2024 | Mar 28, 2024 | S | 800 | $31.52 | Sale −$25,216 | 54,374 | Yes | Form 4 |
| Anders JackChief Financial Officer | Mar 18, 2024 | Mar 20, 2024 | S | 1,261 | $31.58 | Sale −$39,822 | 101,959 | Yes | Form 4 |
| Goldsmith Mark ASee Remarks | Mar 18, 2024 | Mar 20, 2024 | S | 5,788 | $31.58 | Sale −$182,785 | 460,379 | Yes | Form 4 |
| Horn Margaret AChief Operating Officer | Mar 18, 2024 | Mar 20, 2024 | S | 2,914 | $31.58 | Sale −$92,024 | 139,553 | Yes | Form 4 |
| Kelsey Stephen MichaelSee Remarks | Mar 18, 2024 | Mar 20, 2024 | S | 2,123 | $31.58 | Sale −$67,044 | 270,909 | Yes | Form 4 |
| Cislini JeffGeneral Counsel | Mar 18, 2024 | Mar 20, 2024 | S | 1,252 | $31.58 | Sale −$39,538 | 55,874 | Yes | Form 4 |
| Horn Margaret AChief Operating Officer | Mar 12, 2024 | Mar 13, 2024 | M | 7,936 | $4.09 | $32,458 | 150,403 | Yes | Form 4 |
| Horn Margaret AChief Operating Officer | Mar 12, 2024 | Mar 13, 2024 | S | 7,936 | $34.07 | Sale −$270,380 | 142,467 | Yes | Form 4 |
| Horn Margaret AChief Operating Officer | Mar 12, 2024 | Mar 13, 2024 | M · derivative | 7,936 | $4.09 | $32,458 | 44,631 | Yes | Form 4 |
| Horn Margaret AChief Operating Officer | Mar 11, 2024 | Mar 13, 2024 | M | 15,735 | $4.09 | $64,356 | 158,202 | Yes | Form 4 |
| Horn Margaret AChief Operating Officer | Mar 11, 2024 | Mar 13, 2024 | S | 15,735 | $34.02 | Sale −$535,305 | 142,467 | Yes | Form 4 |
| Horn Margaret AChief Operating Officer | Mar 11, 2024 | Mar 13, 2024 | M · derivative | 15,735 | $4.09 | $64,356 | 52,567 | Yes | Form 4 |
| Wang XiaolinSee Remarks | Mar 1, 2024 | Mar 5, 2024 | A | 24,200 | $0.00 | $0 | 84,526 | No | Form 4 |
| Wang XiaolinSee Remarks | Mar 1, 2024 | Mar 5, 2024 | A · derivative | 84,700 | $29.80 | $2,524,060 | 84,700 | No | Form 4 |
| Anders JackChief Financial Officer | Mar 1, 2024 | Mar 5, 2024 | A | 26,400 | $0.00 | $0 | 103,220 | No | Form 4 |
| Anders JackChief Financial Officer | Mar 1, 2024 | Mar 5, 2024 | A · derivative | 92,400 | $29.80 | $2,753,520 | 92,400 | No | Form 4 |
| Kelsey Stephen MichaelSee Remarks | Mar 1, 2024 | Mar 5, 2024 | A | 51,400 | $0.00 | $0 | 273,032 | No | Form 4 |
| Kelsey Stephen MichaelSee Remarks | Mar 1, 2024 | Mar 5, 2024 | A · derivative | 179,900 | $29.80 | $5,361,020 | 179,900 | No | Form 4 |
| Cislini JeffGeneral Counsel | Mar 1, 2024 | Mar 5, 2024 | A | 21,000 | $0.00 | $0 | 57,126 | No | Form 4 |
| Cislini JeffGeneral Counsel | Mar 1, 2024 | Mar 5, 2024 | A · derivative | 73,500 | $29.80 | $2,190,300 | 73,500 | No | Form 4 |
| Goldsmith Mark ASee Remarks | Mar 1, 2024 | Mar 5, 2024 | A | 90,000 | $0.00 | $0 | 466,167 | No | Form 4 |
| Goldsmith Mark ASee Remarks | Mar 1, 2024 | Mar 5, 2024 | A · derivative | 314,000 | $29.80 | $9,357,200 | 314,000 | No | Form 4 |