STOKStoke Therapeutics, Inc.
- Market cap
- $1.62B
- as of 2026-10-23
- Latest close
- $25.04
- as of 2026-10-23
- Sector
- Healthcare
- as of 2026-10-24
- Industry
- Biotechnology
- as of 2026-10-24
Cluster
No cluster in the last 90 days under the default rule (14d · ≥2 insiders · all roles).
Form 4 historysince 2023-12-05
Dashed line = amended filing (Form 4/A)
| Insider | Traded | Filed | Type | Shares | Price | Value | Owned after | 10b5-1 plan | Filing |
|---|---|---|---|---|---|---|---|---|---|
| Allan JonathanGENERAL COUNSEL & CORP SEC | Oct 2 | Oct 2 | S | 627 | $26.33 | Sale −$16,509 | 20,598 | Yes | Form 4 |
| Ticho BarryCHIEF MEDICAL OFFICER | Oct 1 | Oct 2 | S | 1,051 | $26.16 | Sale −$27,494 | 19,059 | Yes | Form 4 |
| Cumbo Alexander | Sep 23 | Sep 25 | A · derivative | 39,674 | $26.11 | $1,035,888 | 39,674 | No | Form 4 |
| Ticho BarryCHIEF MEDICAL OFFICER | Sep 1 | Sep 3 | S | 3,945 | $30.51 | Sale −$120,362 | 21,710 | Yes | Form 4 |
| Ticho BarryCHIEF MEDICAL OFFICER | Sep 1 | Sep 3 | S | 1,600 | $31.06 | Sale −$49,696 | 20,110 | Yes | Form 4 |
| Kaye Edward M. MD | Aug 18 | Aug 18 | S | 11,930 | $32.01 | Sale −$381,879 | 125,194 | No | Form 4 |
| Kaye Edward M. MD | Aug 18 | Aug 18 | S | 637 | $32.47 | Sale −$20,683 | 124,557 | No | Form 4 |
| Ticho BarryCHIEF MEDICAL OFFICER | Aug 18 | Aug 18 | S | 4,525 | $32.01 | Sale −$144,845 | 25,897 | No | Form 4 |
| Ticho BarryCHIEF MEDICAL OFFICER | Aug 18 | Aug 18 | S | 242 | $32.47 | Sale −$7,858 | 25,655 | No | Form 4 |
| Allan JonathanGENERAL COUNSEL & CORP SEC | Aug 18 | Aug 18 | S | 2,716 | $32.01 | Sale −$86,939 | 21,370 | No | Form 4 |
| Allan JonathanGENERAL COUNSEL & CORP SEC | Aug 18 | Aug 18 | S | 145 | $32.47 | Sale −$4,708 | 21,225 | No | Form 4 |
| Kaye Edward M. MD | Aug 14 | Aug 18 | M | 26,250 | $0.00 | $0 | 137,124 | No | Form 4 |
| Kaye Edward M. MD | Aug 14 | Aug 18 | M · derivative | 26,250 | $0.00 | $0 | not reported | No | Form 4 |
| Ticho BarryCHIEF MEDICAL OFFICER | Aug 14 | Aug 18 | M | 10,000 | $0.00 | $0 | 30,422 | No | Form 4 |
| Ticho BarryCHIEF MEDICAL OFFICER | Aug 14 | Aug 18 | M · derivative | 10,000 | $0.00 | $0 | not reported | No | Form 4 |
| Allan JonathanGENERAL COUNSEL & CORP SEC | Aug 14 | Aug 18 | M | 6,000 | $0.00 | $0 | 24,086 | No | Form 4 |
| Allan JonathanGENERAL COUNSEL & CORP SEC | Aug 14 | Aug 18 | M · derivative | 6,000 | $0.00 | $0 | not reported | No | Form 4 |
| Ticho BarryCHIEF MEDICAL OFFICER | Aug 3 | Aug 5 | S | 5,907 | $28.95 | Sale −$171,008 | 21,691 | Yes | Form 4 |
| Ticho BarryCHIEF MEDICAL OFFICER | Aug 3 | Aug 5 | S | 1,269 | $29.45 | Sale −$37,372 | 20,422 | Yes | Form 4 |
| Harrison Seth Loring | Jul 16 | Jul 17 | G · derivative | 29,555 | $28.80 | $851,184 | not reported | No | Form 4 |
| Harrison Seth Loring | Jul 16 | Jul 17 | G · derivative | 29,555 | $28.80 | $851,184 | 29,555 | No | Form 4 |
| Harrison Seth Loring | Jul 16 | Jul 17 | G · derivative | 14,777 | $26.53 | $392,034 | not reported | No | Form 4 |
| Harrison Seth Loring | Jul 16 | Jul 17 | G · derivative | 14,777 | $26.53 | $392,034 | 14,777 | No | Form 4 |
| Harrison Seth Loring | Jul 16 | Jul 17 | G · derivative | 11,650 | $40.37 | $470,311 | not reported | No | Form 4 |
| Harrison Seth Loring | Jul 16 | Jul 17 | G · derivative | 11,650 | $40.37 | $470,311 | 11,650 | No | Form 4 |
| Harrison Seth Loring | Jul 16 | Jul 17 | G · derivative | 21,000 | $12.96 | $272,160 | not reported | No | Form 4 |
| Harrison Seth Loring | Jul 16 | Jul 17 | G · derivative | 21,000 | $12.96 | $272,160 | 21,000 | No | Form 4 |
| Harrison Seth Loring | Jul 16 | Jul 17 | G · derivative | 19,441 | $12.46 | $242,235 | not reported | No | Form 4 |
| Harrison Seth Loring | Jul 16 | Jul 17 | G · derivative | 19,441 | $12.46 | $242,235 | 19,441 | No | Form 4 |
| Harrison Seth Loring | Jul 16 | Jul 17 | G · derivative | 7,639 | $16.41 | $125,356 | not reported | No | Form 4 |
| Harrison Seth Loring | Jul 16 | Jul 17 | G · derivative | 7,639 | $16.41 | $125,356 | 7,639 | No | Form 4 |
| Harrison Seth Loring | Jul 16 | Jul 17 | G · derivative | 29,747 | $10.90 | $324,242 | not reported | No | Form 4 |
| Harrison Seth Loring | Jul 16 | Jul 17 | G · derivative | 29,747 | $10.90 | $324,242 | 29,747 | No | Form 4 |
| Harrison Seth Loring | Jul 16 | Jul 17 | G · derivative | 17,786 | $29.46 | $523,976 | not reported | No | Form 4 |
| Harrison Seth Loring | Jul 16 | Jul 17 | G · derivative | 17,786 | $29.46 | $523,976 | 17,786 | No | Form 4 |
| McCauley ThomasChief Scientific Officer | Jul 15 | Jul 17 | A · derivative | 225,000 | $29.91 | $6,729,750 | 225,000 | No | Form 4 |
| Ticho BarryCHIEF MEDICAL OFFICER | Jul 1 | Jul 6 | S | 6,728 | $32.62 | Sale −$219,467 | 28,098 | Yes | Form 4 |
| Ticho BarryCHIEF MEDICAL OFFICER | Jul 1 | Jul 6 | S | 500 | $33.27 | Sale −$16,635 | 27,598 | Yes | Form 4 |
| Allan JonathanGENERAL COUNSEL & CORP SEC | Jun 16 | Jun 18 | S | 1,457 | $29.95 | Sale −$43,637 | 18,086 | Yes | Form 4 |
| Levin Arthur A | Jun 3 | Jun 5 | A · derivative | 17,786 | $29.46 | $523,976 | 17,786 | No | Form 4 |
| Harrison Seth Loring | Jun 3 | Jun 5 | A · derivative | 17,786 | $29.46 | $523,976 | 17,786 | No | Form 4 |
| Kaye Edward M. MD | Jun 3 | Jun 5 | A · derivative | 17,786 | $29.46 | $523,976 | 17,786 | No | Form 4 |
| Smith Julie | Jun 3 | Jun 5 | A · derivative | 17,786 | $29.46 | $523,976 | 17,786 | No | Form 4 |
| Tzianabos Arthur | Jun 3 | Jun 5 | A · derivative | 17,786 | $29.46 | $523,976 | 17,786 | No | Form 4 |
| Burstein Jennifer | Jun 3 | Jun 5 | A · derivative | 17,786 | $29.46 | $523,976 | 17,786 | No | Form 4 |
| Krainer Adrian R. | Jun 3 | Jun 5 | A · derivative | 17,786 | $29.46 | $523,976 | 17,786 | No | Form 4 |
| Ticho BarryCHIEF MEDICAL OFFICER | Jun 1 | Jun 3 | S | 1,795 | $30.58 | Sale −$54,891 | 34,826 | Yes | Form 4 |
| Ticho BarryCHIEF MEDICAL OFFICER | May 1 | May 5 | S | 2,243 | $32.79 | Sale −$73,548 | 36,621 | Yes | Form 4 |
| Kahn Clare | Apr 3 | Apr 7 | A · derivative | 30,782 | $32.79 | $1,009,342 | 30,782 | No | Form 4 |
| Ticho BarryCHIEF MEDICAL OFFICER | Apr 1 | Apr 3 | S | 1,838 | $32.66 | Sale −$60,029 | 38,864 | Yes | Form 4 |
| Allan JonathanGENERAL COUNSEL & CORP SEC | Mar 20 | Mar 24 | S | 8,692 | $33.64 | Sale −$292,399 | 20,144 | Yes | Form 4 |
| Allan JonathanGENERAL COUNSEL & CORP SEC | Mar 20 | Mar 24 | S | 601 | $34.41 | Sale −$20,680 | 19,543 | Yes | Form 4 |
| Ticho BarryCHIEF MEDICAL OFFICER | Mar 19 | Mar 19 | M | 1,365 | $2.19 | $2,989 | 42,163 | Yes | Form 4 |
| Ticho BarryCHIEF MEDICAL OFFICER | Mar 19 | Mar 19 | S | 1,461 | $29.99 | Sale −$43,815 | 40,702 | Yes | Form 4 |
| Ticho BarryCHIEF MEDICAL OFFICER | Mar 19 | Mar 19 | M · derivative | 1,365 | $2.19 | $2,989 | 83,035 | Yes | Form 4 |
| Hoitt JasonChief Patient Officer | Mar 18 | Mar 19 | S | 1,762 | $31.28 | Sale −$55,115 | 10,445 | No | Form 4 |
| Hoitt JasonChief Patient Officer | Mar 18 | Mar 19 | S | 139 | $31.79 | Sale −$4,419 | 10,306 | No | Form 4 |
| Hoitt JasonChief Patient Officer | Mar 18 | Mar 19 | S | 30 | $32.85 | Sale −$986 | 10,276 | No | Form 4 |
| Leggett ThomasChief Financial Officer | Mar 18 | Mar 19 | S | 2,173 | $31.28 | Sale −$67,971 | 10,381 | No | Form 4 |
| Leggett ThomasChief Financial Officer | Mar 18 | Mar 19 | S | 172 | $31.79 | Sale −$5,468 | 10,209 | No | Form 4 |
| Leggett ThomasChief Financial Officer | Mar 18 | Mar 19 | S | 37 | $32.85 | Sale −$1,215 | 10,172 | No | Form 4 |
| Ticho BarryCHIEF MEDICAL OFFICER | Mar 18 | Mar 19 | S | 6,100 | $31.28 | Sale −$190,808 | 41,384 | Yes | Form 4 |
| Ticho BarryCHIEF MEDICAL OFFICER | Mar 18 | Mar 19 | S | 483 | $31.79 | Sale −$15,355 | 40,901 | Yes | Form 4 |
| Ticho BarryCHIEF MEDICAL OFFICER | Mar 18 | Mar 19 | S | 103 | $32.85 | Sale −$3,384 | 40,798 | Yes | Form 4 |
| Allan JonathanGENERAL COUNSEL & CORP SEC | Mar 18 | Mar 19 | S | 4,222 | $31.28 | Sale −$132,064 | 29,242 | No | Form 4 |
| Allan JonathanGENERAL COUNSEL & CORP SEC | Mar 18 | Mar 19 | S | 334 | $31.79 | Sale −$10,618 | 28,908 | No | Form 4 |
| Allan JonathanGENERAL COUNSEL & CORP SEC | Mar 18 | Mar 19 | S | 72 | $32.85 | Sale −$2,365 | 28,836 | No | Form 4 |
| Hoitt JasonChief Patient Officer | Mar 17 | Mar 19 | S | 1,033 | $32.74 | Sale −$33,820 | 12,955 | No | Form 4 |
| Hoitt JasonChief Patient Officer | Mar 17 | Mar 19 | S | 748 | $33.38 | Sale −$24,968 | 12,207 | No | Form 4 |
| Leggett ThomasChief Financial Officer | Mar 17 | Mar 19 | S | 1,274 | $32.74 | Sale −$41,711 | 13,476 | No | Form 4 |
| Leggett ThomasChief Financial Officer | Mar 17 | Mar 19 | S | 922 | $33.38 | Sale −$30,776 | 12,554 | No | Form 4 |
| Ticho BarryCHIEF MEDICAL OFFICER | Mar 17 | Mar 19 | S | 3,577 | $32.74 | Sale −$117,111 | 50,071 | Yes | Form 4 |
| Ticho BarryCHIEF MEDICAL OFFICER | Mar 17 | Mar 19 | S | 2,587 | $33.38 | Sale −$86,354 | 47,484 | Yes | Form 4 |
| Allan JonathanGENERAL COUNSEL & CORP SEC | Mar 17 | Mar 19 | S | 2,476 | $32.74 | Sale −$81,064 | 35,255 | No | Form 4 |
| Allan JonathanGENERAL COUNSEL & CORP SEC | Mar 17 | Mar 19 | S | 1,791 | $33.38 | Sale −$59,784 | 33,464 | No | Form 4 |
| Kaye Edward M. MD | Mar 15 | Mar 17 | M | 35,500 | $0.00 | $0 | 84,624 | No | Form 4 |
| Kaye Edward M. MD | Mar 15 | Mar 17 | M | 26,250 | $0.00 | $0 | 110,874 | No | Form 4 |
| Kaye Edward M. MD | Mar 15 | Mar 17 | M · derivative | 35,500 | $0.00 | $0 | 35,500 | No | Form 4 |
| Kaye Edward M. MD | Mar 15 | Mar 17 | M · derivative | 26,250 | $0.00 | $0 | 52,500 | No | Form 4 |
| Hoitt JasonChief Patient Officer | Mar 15 | Mar 17 | M | 10,000 | $0.00 | $0 | 13,988 | No | Form 4 |
| Hoitt JasonChief Patient Officer | Mar 15 | Mar 17 | M · derivative | 10,000 | $0.00 | $0 | 30,000 | No | Form 4 |
| Leggett ThomasChief Financial Officer | Mar 15 | Mar 17 | M | 14,750 | $0.00 | $0 | 14,750 | No | Form 4 |
| Leggett ThomasChief Financial Officer | Mar 15 | Mar 17 | M · derivative | 14,750 | $0.00 | $0 | 44,250 | No | Form 4 |
| Ticho BarryCHIEF MEDICAL OFFICER | Mar 15 | Mar 17 | M | 13,100 | $0.00 | $0 | 32,898 | No | Form 4 |
| Ticho BarryCHIEF MEDICAL OFFICER | Mar 15 | Mar 17 | M | 10,000 | $0.00 | $0 | 42,898 | No | Form 4 |
| Ticho BarryCHIEF MEDICAL OFFICER | Mar 15 | Mar 17 | M | 10,750 | $0.00 | $0 | 53,648 | No | Form 4 |
| Ticho BarryCHIEF MEDICAL OFFICER | Mar 15 | Mar 17 | M · derivative | 13,100 | $0.00 | $0 | 13,100 | No | Form 4 |
| Ticho BarryCHIEF MEDICAL OFFICER | Mar 15 | Mar 17 | M · derivative | 10,000 | $0.00 | $0 | 20,000 | No | Form 4 |
| Ticho BarryCHIEF MEDICAL OFFICER | Mar 15 | Mar 17 | M · derivative | 10,750 | $0.00 | $0 | 32,250 | No | Form 4 |
| Allan JonathanGENERAL COUNSEL & CORP SEC | Mar 15 | Mar 17 | M | 7,475 | $0.00 | $0 | 19,731 | No | Form 4 |
| Allan JonathanGENERAL COUNSEL & CORP SEC | Mar 15 | Mar 17 | M | 6,000 | $0.00 | $0 | 25,731 | No | Form 4 |
| Allan JonathanGENERAL COUNSEL & CORP SEC | Mar 15 | Mar 17 | M | 12,000 | $0.00 | $0 | 37,731 | No | Form 4 |
| Allan JonathanGENERAL COUNSEL & CORP SEC | Mar 15 | Mar 17 | M · derivative | 7,475 | $0.00 | $0 | 7,475 | No | Form 4 |
| Allan JonathanGENERAL COUNSEL & CORP SEC | Mar 15 | Mar 17 | M · derivative | 6,000 | $0.00 | $0 | 12,000 | No | Form 4 |
| Allan JonathanGENERAL COUNSEL & CORP SEC | Mar 15 | Mar 17 | M · derivative | 12,000 | $0.00 | $0 | 36,000 | No | Form 4 |
| Levin Arthur A | Mar 13 | Mar 17 | S | 605 | $36.80 | Sale −$22,264 | 4,237 | Yes | Form 4 |
| Tzianabos ArthurInterim Executive Chair | Mar 10 | Mar 12 | M | 3,955 | $8.33 | $32,945 | 35,694 | Yes | Form 4 |
| Tzianabos ArthurInterim Executive Chair | Mar 10 | Mar 12 | S | 4,355 | $40.00 | Sale −$174,200 | 31,339 | Yes | Form 4 |
| Tzianabos ArthurInterim Executive Chair | Mar 10 | Mar 12 | M · derivative | 3,955 | $8.33 | $32,945 | 118,696 | Yes | Form 4 |
| Krainer Adrian R. | Mar 10 | Mar 12 | S | 33,243 | $39.74 | Sale −$1,321,077 | 283,302 | Yes | Form 4 |
| Krainer Adrian R. | Mar 2 | Mar 4 | S | 7,229 | $39.66 | Sale −$286,702 | 316,545 | Yes | Form 4 |
| Smith Ian FChief Executive Officer | Feb 17 | Feb 19 | A · derivative | 193,000 | $31.09 | $6,000,370 | 193,000 | No | Form 4 |
| Smith Ian FChief Executive Officer | Feb 17 | Feb 19 | A · derivative | 129,000 | $0.00 | $0 | 129,000 | No | Form 4 |
| Hoitt JasonChief Patient Officer | Feb 17 | Feb 19 | A · derivative | 72,000 | $31.09 | $2,238,480 | 72,000 | No | Form 4 |
| Hoitt JasonChief Patient Officer | Feb 17 | Feb 19 | A · derivative | 48,000 | $0.00 | $0 | 48,000 | No | Form 4 |
| Leggett ThomasChief Financial Officer | Feb 17 | Feb 19 | A · derivative | 60,000 | $31.09 | $1,865,400 | 60,000 | No | Form 4 |
| Leggett ThomasChief Financial Officer | Feb 17 | Feb 19 | A · derivative | 40,000 | $0.00 | $0 | 40,000 | No | Form 4 |
| Ticho BarryCHIEF MEDICAL OFFICER | Feb 17 | Feb 19 | A · derivative | 60,000 | $31.09 | $1,865,400 | 60,000 | No | Form 4 |
| Ticho BarryCHIEF MEDICAL OFFICER | Feb 17 | Feb 19 | A · derivative | 40,000 | $0.00 | $0 | 40,000 | No | Form 4 |
| Allan JonathanGENERAL COUNSEL & CORP SEC | Feb 17 | Feb 19 | A · derivative | 53,000 | $31.09 | $1,647,770 | 53,000 | No | Form 4 |
| Allan JonathanGENERAL COUNSEL & CORP SEC | Feb 17 | Feb 19 | A · derivative | 35,000 | $0.00 | $0 | 35,000 | No | Form 4 |
| Levin Arthur A | Dec 31, 2025 | Jan 5 | M | 1,211 | $0.00 | $0 | 4,842 | No | Form 4 |
| Levin Arthur A | Dec 31, 2025 | Jan 5 | M · derivative | 1,211 | $0.00 | $0 | not reported | No | Form 4 |
| Kaye Edward M. MD | Dec 8, 2025 | Dec 10, 2025 | S | 3,825 | $31.44 | Sale −$120,258 | 58,729 | Yes | Form 4 |
| Kaye Edward M. MD | Dec 8, 2025 | Dec 10, 2025 | S | 8,274 | $32.52 | Sale −$269,070 | 50,455 | Yes | Form 4 |
| Kaye Edward M. MD | Dec 8, 2025 | Dec 10, 2025 | S | 1,331 | $33.10 | Sale −$44,056 | 49,124 | Yes | Form 4 |
| Allan JonathanGENERAL COUNSEL & CORP SEC | Dec 8, 2025 | Dec 10, 2025 | S | 1,300 | $31.60 | Sale −$41,080 | 14,509 | Yes | Form 4 |
| Allan JonathanGENERAL COUNSEL & CORP SEC | Dec 8, 2025 | Dec 10, 2025 | S | 2,678 | $32.61 | Sale −$87,330 | 11,831 | Yes | Form 4 |
| Kaye Edward M. MD | Dec 5, 2025 | Dec 5, 2025 | S | 6,367 | $31.33 | Sale −$199,478 | 64,735 | Yes | Form 4 |
| Kaye Edward M. MD | Dec 5, 2025 | Dec 5, 2025 | S | 1,681 | $31.15 | Sale −$52,363 | 63,054 | Yes | Form 4 |
| Kaye Edward M. MD | Dec 5, 2025 | Dec 5, 2025 | S | 500 | $31.85 | Sale −$15,925 | 62,554 | Yes | Form 4 |
| Ticho BarryCHIEF MEDICAL OFFICER | Dec 5, 2025 | Dec 5, 2025 | S | 1,673 | $31.33 | Sale −$52,415 | 21,787 | Yes | Form 4 |
| Ticho BarryCHIEF MEDICAL OFFICER | Dec 5, 2025 | Dec 5, 2025 | S | 1,989 | $31.35 | Sale −$62,355 | 19,798 | Yes | Form 4 |
| Allan JonathanGENERAL COUNSEL & CORP SEC | Dec 5, 2025 | Dec 5, 2025 | S | 1,004 | $31.33 | Sale −$31,455 | 23,590 | Yes | Form 4 |
| Allan JonathanGENERAL COUNSEL & CORP SEC | Dec 5, 2025 | Dec 5, 2025 | S | 5,437 | $31.08 | Sale −$168,982 | 18,153 | Yes | Form 4 |
| Allan JonathanGENERAL COUNSEL & CORP SEC | Dec 5, 2025 | Dec 5, 2025 | S | 2,344 | $31.76 | Sale −$74,445 | 15,809 | Yes | Form 4 |
| Kaye Edward M. MD | Dec 4, 2025 | Dec 5, 2025 | S | 5,222 | $30.76 | Sale −$160,629 | 72,333 | Yes | Form 4 |
| Kaye Edward M. MD | Dec 4, 2025 | Dec 5, 2025 | S | 1,231 | $31.32 | Sale −$38,555 | 71,102 | Yes | Form 4 |
| Ticho BarryCHIEF MEDICAL OFFICER | Dec 4, 2025 | Dec 5, 2025 | S | 1,373 | $30.76 | Sale −$42,233 | 23,783 | Yes | Form 4 |
| Ticho BarryCHIEF MEDICAL OFFICER | Dec 4, 2025 | Dec 5, 2025 | S | 323 | $31.32 | Sale −$10,116 | 23,460 | Yes | Form 4 |
| Allan JonathanGENERAL COUNSEL & CORP SEC | Dec 4, 2025 | Dec 5, 2025 | S | 824 | $30.76 | Sale −$25,346 | 24,788 | Yes | Form 4 |
| Allan JonathanGENERAL COUNSEL & CORP SEC | Dec 4, 2025 | Dec 5, 2025 | S | 194 | $31.32 | Sale −$6,076 | 24,594 | Yes | Form 4 |
| Kaye Edward M. MD | Dec 3, 2025 | Dec 5, 2025 | M | 26,250 | $0.00 | $0 | 77,555 | Yes | Form 4 |
| Kaye Edward M. MD | Dec 3, 2025 | Dec 5, 2025 | M · derivative | 26,250 | $0.00 | $0 | not reported | Yes | Form 4 |
| Ticho BarryCHIEF MEDICAL OFFICER | Dec 3, 2025 | Dec 5, 2025 | M | 10,000 | $0.00 | $0 | 25,156 | Yes | Form 4 |
| Ticho BarryCHIEF MEDICAL OFFICER | Dec 3, 2025 | Dec 5, 2025 | M · derivative | 10,000 | $0.00 | $0 | not reported | Yes | Form 4 |
| Allan JonathanGENERAL COUNSEL & CORP SEC | Dec 3, 2025 | Dec 5, 2025 | M | 6,000 | $0.00 | $0 | 25,612 | Yes | Form 4 |
| Allan JonathanGENERAL COUNSEL & CORP SEC | Dec 3, 2025 | Dec 5, 2025 | M · derivative | 6,000 | $0.00 | $0 | not reported | Yes | Form 4 |
| Kaye Edward M. MD | Dec 3, 2025 | Dec 3, 2025 | S | 419 | $30.34 | Sale −$12,712 | 51,956 | No | Form 4 |
| Kaye Edward M. MD | Dec 3, 2025 | Dec 3, 2025 | S | 651 | $30.85 | Sale −$20,083 | 51,305 | No | Form 4 |
| Ticho BarryCHIEF MEDICAL OFFICER | Dec 3, 2025 | Dec 3, 2025 | S | 789 | $30.34 | Sale −$23,938 | 16,381 | No | Form 4 |
| Ticho BarryCHIEF MEDICAL OFFICER | Dec 3, 2025 | Dec 3, 2025 | S | 1,225 | $30.85 | Sale −$37,791 | 15,156 | No | Form 4 |
| Allan JonathanGENERAL COUNSEL & CORP SEC | Dec 3, 2025 | Dec 3, 2025 | S | 898 | $30.34 | Sale −$27,245 | 21,006 | No | Form 4 |
| Allan JonathanGENERAL COUNSEL & CORP SEC | Dec 3, 2025 | Dec 3, 2025 | S | 1,394 | $30.85 | Sale −$43,005 | 19,612 | No | Form 4 |
| Kaye Edward M. MD | Dec 2, 2025 | Dec 3, 2025 | S | 661 | $29.56 | Sale −$19,539 | 52,780 | No | Form 4 |
| Kaye Edward M. MD | Dec 2, 2025 | Dec 3, 2025 | S | 405 | $30.14 | Sale −$12,207 | 52,375 | No | Form 4 |
| Ticho BarryCHIEF MEDICAL OFFICER | Dec 2, 2025 | Dec 3, 2025 | S | 1,244 | $29.56 | Sale −$36,773 | 17,932 | No | Form 4 |
| Ticho BarryCHIEF MEDICAL OFFICER | Dec 2, 2025 | Dec 3, 2025 | S | 762 | $30.14 | Sale −$22,967 | 17,170 | No | Form 4 |
| Allan JonathanGENERAL COUNSEL & CORP SEC | Dec 2, 2025 | Dec 3, 2025 | S | 1,416 | $29.56 | Sale −$41,857 | 22,772 | No | Form 4 |
| Allan JonathanGENERAL COUNSEL & CORP SEC | Dec 2, 2025 | Dec 3, 2025 | S | 868 | $30.14 | Sale −$26,162 | 21,904 | No | Form 4 |
| Kaye Edward M. MD | Dec 1, 2025 | Dec 3, 2025 | M · derivative | 4,317 | $0.00 | $0 | not reported | No | Form 4 |
| Ticho BarryCHIEF MEDICAL OFFICER | Dec 1, 2025 | Dec 3, 2025 | M | 11,981 | $0.00 | $0 | 19,176 | No | Form 4 |
| Ticho BarryCHIEF MEDICAL OFFICER | Dec 1, 2025 | Dec 3, 2025 | M · derivative | 11,981 | $0.00 | $0 | not reported | No | Form 4 |
| Allan JonathanGENERAL COUNSEL & CORP SEC | Dec 1, 2025 | Dec 3, 2025 | M | 12,357 | $0.00 | $0 | 24,188 | No | Form 4 |
| Allan JonathanGENERAL COUNSEL & CORP SEC | Dec 1, 2025 | Dec 3, 2025 | M · derivative | 12,357 | $0.00 | $0 | not reported | No | Form 4 |
| Kaye Edward M. MD | Dec 1, 2024 | Dec 3, 2025 | M | 4,317 | $0.00 | $0 | 53,441 | No | Form 4 |
| Krainer Adrian R. | Nov 24, 2025 | Nov 26, 2025 | S | 40,472 | $29.72 | Sale −$1,202,828 | 323,774 | Yes | Form 4 |
| Krainer Adrian R. | Nov 14, 2025 | Nov 18, 2025 | S | 19,790 | $26.61 | Sale −$526,612 | 384,928 | Yes | Form 4 |
| Krainer Adrian R. | Nov 14, 2025 | Nov 18, 2025 | S | 20,682 | $27.34 | Sale −$565,446 | 364,246 | Yes | Form 4 |
| Ticho BarryCHIEF MEDICAL OFFICER | Nov 3, 2025 | Nov 5, 2025 | S | 3,776 | $25.22 | Sale −$95,231 | 9,350 | Yes | Form 4 |
| Ticho BarryCHIEF MEDICAL OFFICER | Nov 3, 2025 | Nov 5, 2025 | S | 1,455 | $26.02 | Sale −$37,859 | 7,895 | Yes | Form 4 |
| Ticho BarryCHIEF MEDICAL OFFICER | Nov 3, 2025 | Nov 5, 2025 | S | 600 | $27.54 | Sale −$16,524 | 7,295 | Yes | Form 4 |
| Ticho BarryCHIEF MEDICAL OFFICER | Nov 3, 2025 | Nov 5, 2025 | S | 100 | $29.35 | Sale −$2,935 | 7,195 | Yes | Form 4 |
| Smith Ian FChief Executive Officer | Oct 8, 2025 | Oct 14, 2025 | A · derivative | 570,000 | $30.50 | $17,385,000 | 570,000 | No | Form 4 |
| Smith Ian FChief Executive Officer | Oct 8, 2025 | Oct 14, 2025 | A · derivative | 380,000 | $0.00 | $0 | 380,000 | No | Form 4 |
| Kaye Edward M. MD | Oct 8, 2025 | Oct 10, 2025 | M | 25,000 | $0.60 | $15,000 | 74,124 | Yes | Form 4 |
| Kaye Edward M. MD | Oct 8, 2025 | Oct 10, 2025 | S | 25,000 | $30.00 | Sale −$750,000 | 49,124 | Yes | Form 4 |
| Kaye Edward M. MD | Oct 8, 2025 | Oct 10, 2025 | M · derivative | 25,000 | $0.60 | $15,000 | 542,801 | Yes | Form 4 |
| Kaye Edward M. MD | Oct 3, 2025 | Oct 7, 2025 | S | 42,461 | $25.09 | Sale −$1,065,346 | 49,124 | Yes | Form 4 |
| Allan JonathanGENERAL COUNSEL & CORP SEC | Oct 3, 2025 | Oct 7, 2025 | M | 10,000 | $9.15 | $91,500 | 21,831 | Yes | Form 4 |
| Allan JonathanGENERAL COUNSEL & CORP SEC | Oct 3, 2025 | Oct 7, 2025 | S | 10,000 | $25.07 | Sale −$250,700 | 11,831 | Yes | Form 4 |
| Allan JonathanGENERAL COUNSEL & CORP SEC | Oct 3, 2025 | Oct 7, 2025 | M · derivative | 10,000 | $9.15 | $91,500 | 34,800 | Yes | Form 4 |
| Ticho BarryCHIEF MEDICAL OFFICER | Oct 1, 2025 | Oct 3, 2025 | S | 5,343 | $23.64 | Sale −$126,309 | 13,126 | Yes | Form 4 |
| Levin Arthur A | Sep 30, 2025 | Oct 1, 2025 | M | 1,211 | $0.00 | $0 | 3,631 | No | Form 4 |
| Levin Arthur A | Sep 30, 2025 | Oct 1, 2025 | M · derivative | 1,211 | $0.00 | $0 | 1,211 | No | Form 4 |
| Kaye Edward M. MD | Sep 4, 2025 | Sep 5, 2025 | D · derivative | 178,500 | $8.33 | $1,486,905 | 37,500 | No | Form 4 |
| Kaye Edward M. MD | Sep 4, 2025 | Sep 5, 2025 | D · derivative | 144,000 | $0.00 | $0 | not reported | No | Form 4 |
| Allan JonathanGENERAL COUNSEL & CORP SEC | Sep 3, 2025 | Sep 3, 2025 | S | 6,345 | $20.07 | Sale −$127,344 | 11,831 | Yes | Form 4 |
| Kaye Edward M. MD | Sep 3, 2025 | Sep 3, 2025 | S | 45,996 | $20.13 | Sale −$925,899 | 91,585 | Yes | Form 4 |
| Allan JonathanGENERAL COUNSEL & CORP SEC | Sep 2, 2025 | Sep 3, 2025 | M | 9,150 | $7.07 | $64,691 | 33,098 | Yes | Form 4 |
| Allan JonathanGENERAL COUNSEL & CORP SEC | Sep 2, 2025 | Sep 3, 2025 | S | 14,922 | $20.14 | Sale −$300,529 | 18,176 | Yes | Form 4 |
| Allan JonathanGENERAL COUNSEL & CORP SEC | Sep 2, 2025 | Sep 3, 2025 | M · derivative | 9,150 | $7.07 | $64,691 | 15,801 | Yes | Form 4 |
| Kaye Edward M. MD | Sep 2, 2025 | Sep 3, 2025 | S | 14,860 | $20.14 | Sale −$299,280 | 137,581 | Yes | Form 4 |
| Ticho BarryCHIEF MEDICAL OFFICER | Sep 2, 2025 | Sep 3, 2025 | S | 5,501 | $19.87 | Sale −$109,305 | 18,469 | Yes | Form 4 |
| Allan JonathanGENERAL COUNSEL & CORP SEC | Aug 29, 2025 | Sep 3, 2025 | M | 850 | $7.07 | $6,010 | 24,798 | Yes | Form 4 |
| Allan JonathanGENERAL COUNSEL & CORP SEC | Aug 29, 2025 | Sep 3, 2025 | S | 850 | $20.00 | Sale −$17,000 | 23,948 | Yes | Form 4 |
| Allan JonathanGENERAL COUNSEL & CORP SEC | Aug 29, 2025 | Sep 3, 2025 | M · derivative | 850 | $7.07 | $6,010 | 24,951 | Yes | Form 4 |
| Kaye Edward M. MD | Aug 29, 2025 | Sep 3, 2025 | S | 1,029 | $20.00 | Sale −$20,580 | 152,441 | Yes | Form 4 |
| Allan JonathanGENERAL COUNSEL & CORP SEC | Aug 18, 2025 | Aug 20, 2025 | S | 1,683 | $18.24 | Sale −$30,698 | 23,948 | No | Form 4 |
| Kaye Edward M. MD | Aug 18, 2025 | Aug 20, 2025 | S | 12,126 | $18.24 | Sale −$221,178 | 153,470 | No | Form 4 |
| Ticho BarryCHIEF MEDICAL OFFICER | Aug 18, 2025 | Aug 20, 2025 | S | 2,805 | $18.24 | Sale −$51,163 | 23,970 | No | Form 4 |
| Kaye Edward M. MD | Aug 14, 2025 | Aug 18, 2025 | M | 26,250 | $0.00 | $0 | 165,596 | No | Form 4 |
| Kaye Edward M. MD | Aug 14, 2025 | Aug 18, 2025 | A · derivative | 52,500 | $0.00 | $0 | 52,500 | No | Form 4 |
| Kaye Edward M. MD | Aug 14, 2025 | Aug 18, 2025 | M · derivative | 26,250 | $0.00 | $0 | 26,250 | No | Form 4 |
| Allan JonathanGENERAL COUNSEL & CORP SEC | Aug 14, 2025 | Aug 18, 2025 | M | 6,000 | $0.00 | $0 | 25,631 | No | Form 4 |
| Allan JonathanGENERAL COUNSEL & CORP SEC | Aug 14, 2025 | Aug 18, 2025 | A · derivative | 12,000 | $0.00 | $0 | 12,000 | No | Form 4 |
| Allan JonathanGENERAL COUNSEL & CORP SEC | Aug 14, 2025 | Aug 18, 2025 | M · derivative | 6,000 | $0.00 | $0 | 6,000 | No | Form 4 |
| Ticho BarryCHIEF MEDICAL OFFICER | Aug 14, 2025 | Aug 18, 2025 | M | 10,000 | $0.00 | $0 | 26,775 | No | Form 4 |
| Ticho BarryCHIEF MEDICAL OFFICER | Aug 14, 2025 | Aug 18, 2025 | A · derivative | 20,000 | $0.00 | $0 | 20,000 | No | Form 4 |
| Ticho BarryCHIEF MEDICAL OFFICER | Aug 14, 2025 | Aug 18, 2025 | M · derivative | 10,000 | $0.00 | $0 | 10,000 | No | Form 4 |
| Allan JonathanGENERAL COUNSEL & CORP SEC | Aug 13, 2025 | Aug 15, 2025 | S | 13,712 | $15.00 | Sale −$205,680 | 19,631 | Yes | Form 4 |
| Ticho BarryCHIEF MEDICAL OFFICER | Aug 1, 2025 | Aug 5, 2025 | S | 4,504 | $12.82 | Sale −$57,741 | 16,775 | Yes | Form 4 |
| Ticho BarryCHIEF MEDICAL OFFICER | Jul 1, 2025 | Jul 2, 2025 | S | 4,503 | $11.63 | Sale −$52,370 | 21,279 | Yes | Form 4 |
| Levin Arthur A | Jun 30, 2025 | Jul 2, 2025 | M | 1,210 | $0.00 | $0 | 2,420 | No | Form 4 |
| Levin Arthur A | Jun 30, 2025 | Jul 2, 2025 | M · derivative | 1,210 | $0.00 | $0 | 2,422 | No | Form 4 |
| Skorpios Trust | Jun 4, 2025 | Jun 6, 2025 | S | 3,000,000 | $10.20 | Sale −$30,600,000 | 3,906,181 | No | Form 4 |
| Ticho BarryCHIEF MEDICAL OFFICER | Jun 3, 2025 | Jun 4, 2025 | S | 6,471 | $10.03 | Sale −$64,904 | 25,782 | Yes | Form 4 |
| Burstein Jennifer | Jun 3, 2025 | Jun 4, 2025 | A · derivative | 29,747 | $10.90 | $324,242 | 29,747 | No | Form 4 |
| Harrison Seth Loring | Jun 3, 2025 | Jun 4, 2025 | A · derivative | 29,747 | $10.90 | $324,242 | 29,747 | No | Form 4 |
| Krainer Adrian R. | Jun 3, 2025 | Jun 4, 2025 | A · derivative | 29,747 | $10.90 | $324,242 | 29,747 | No | Form 4 |
| Menzel Garry E | Jun 3, 2025 | Jun 4, 2025 | A · derivative | 29,747 | $10.90 | $324,242 | 29,747 | No | Form 4 |
| Levin Arthur A | Jun 3, 2025 | Jun 4, 2025 | A · derivative | 29,747 | $10.90 | $324,242 | 29,747 | No | Form 4 |
| Smith Julie | Jun 3, 2025 | Jun 4, 2025 | A · derivative | 29,747 | $10.90 | $324,242 | 29,747 | No | Form 4 |
| Ticho BarryCHIEF MEDICAL OFFICER | Jun 2, 2025 | Jun 4, 2025 | S | 1,745 | $10.00 | Sale −$17,450 | 32,253 | Yes | Form 4 |
| Ticho BarryCHIEF MEDICAL OFFICER | May 2, 2025 | May 5, 2025 | S | 22,790 | $10.03 | Sale −$228,584 | 33,998 | Yes | Form 4 |
| Ticho BarryCHIEF MEDICAL OFFICER | May 1, 2025 | May 5, 2025 | S | 3,841 | $10.00 | Sale −$38,410 | 56,788 | Yes | Form 4 |
| Levin Arthur A | Mar 31, 2025 | Apr 2, 2025 | M | 1,210 | $0.00 | $0 | 1,210 | No | Form 4 |
| Levin Arthur A | Mar 31, 2025 | Apr 2, 2025 | M · derivative | 1,210 | $0.00 | $0 | 3,632 | No | Form 4 |
| Allan JonathanGENERAL COUNSEL & CORP SEC | Mar 20, 2025 | Mar 20, 2025 | A · derivative | 72,000 | $8.33 | $599,760 | 72,000 | No | Form 4 |
| Allan JonathanGENERAL COUNSEL & CORP SEC | Mar 20, 2025 | Mar 20, 2025 | A · derivative | 48,000 | $0.00 | $0 | 48,000 | No | Form 4 |
| Ticho BarryCHIEF MEDICAL OFFICER | Mar 20, 2025 | Mar 20, 2025 | A · derivative | 64,000 | $8.33 | $533,120 | 64,000 | No | Form 4 |
| Ticho BarryCHIEF MEDICAL OFFICER | Mar 20, 2025 | Mar 20, 2025 | A · derivative | 43,000 | $0.00 | $0 | 43,000 | No | Form 4 |
| Kaye Edward M. MD | Mar 20, 2025 | Mar 20, 2025 | A · derivative | 216,000 | $8.33 | $1,799,280 | 216,000 | No | Form 4 |
| Kaye Edward M. MD | Mar 20, 2025 | Mar 20, 2025 | A · derivative | 144,000 | $0.00 | $0 | 144,000 | No | Form 4 |
| Leggett ThomasChief Financial Officer | Mar 20, 2025 | Mar 20, 2025 | A · derivative | 89,000 | $8.33 | $741,370 | 89,000 | No | Form 4 |
| Leggett ThomasChief Financial Officer | Mar 20, 2025 | Mar 20, 2025 | A · derivative | 59,000 | $0.00 | $0 | 59,000 | No | Form 4 |
| Tzianabos ArthurInterim Executive Chair | Mar 20, 2025 | Mar 20, 2025 | A · derivative | 122,651 | $8.33 | $1,021,683 | 122,651 | No | Form 4 |
| Smith Ian FInterim CEO | Mar 20, 2025 | Mar 20, 2025 | A · derivative | 238,420 | $8.33 | $1,986,039 | 238,420 | No | Form 4 |
| Allan JonathanGENERAL COUNSEL & CORP SEC | Mar 19, 2025 | Mar 20, 2025 | S | 1,945 | $8.27 | Sale −$16,085 | 31,565 | No | Form 4 |
| Ticho BarryCHIEF MEDICAL OFFICER | Mar 19, 2025 | Mar 20, 2025 | S | 3,333 | $8.27 | Sale −$27,564 | 60,629 | No | Form 4 |
| Kaye Edward M. MD | Mar 19, 2025 | Mar 20, 2025 | S | 8,907 | $8.27 | Sale −$73,661 | 139,346 | No | Form 4 |
| Levin Arthur A | Mar 19, 2025 | Mar 20, 2025 | A · derivative | 4,842 | $0.00 | $0 | 4,842 | No | Form 4 |
| Allan JonathanGENERAL COUNSEL & CORP SEC | Mar 18, 2025 | Mar 20, 2025 | S | 2,266 | $8.67 | Sale −$19,646 | 33,510 | No | Form 4 |
| Ticho BarryCHIEF MEDICAL OFFICER | Mar 18, 2025 | Mar 20, 2025 | S | 3,884 | $8.67 | Sale −$33,674 | 63,962 | No | Form 4 |
| Kaye Edward M. MD | Mar 18, 2025 | Mar 20, 2025 | S | 10,382 | $8.67 | Sale −$90,012 | 148,253 | No | Form 4 |
| Kaye Edward M. MDCEO | Mar 15, 2025 | Mar 18, 2025 | M | 35,500 | $0.00 | $0 | 132,385 | No | Form 4 |
| Kaye Edward M. MDCEO | Mar 15, 2025 | Mar 18, 2025 | M | 26,250 | $0.00 | $0 | 158,635 | No | Form 4 |
| Kaye Edward M. MDCEO | Mar 15, 2025 | Mar 18, 2025 | M · derivative | 35,500 | $0.00 | $0 | 71,000 | No | Form 4 |
| Kaye Edward M. MDCEO | Mar 15, 2025 | Mar 18, 2025 | M · derivative | 26,250 | $0.00 | $0 | 78,750 | No | Form 4 |
| Ticho BarryCHIEF MEDICAL OFFICER | Mar 15, 2025 | Mar 18, 2025 | M | 13,100 | $0.00 | $0 | 57,846 | No | Form 4 |
| Ticho BarryCHIEF MEDICAL OFFICER | Mar 15, 2025 | Mar 18, 2025 | M | 10,000 | $0.00 | $0 | 67,846 | No | Form 4 |
| Ticho BarryCHIEF MEDICAL OFFICER | Mar 15, 2025 | Mar 18, 2025 | M · derivative | 13,100 | $0.00 | $0 | 26,200 | No | Form 4 |
| Ticho BarryCHIEF MEDICAL OFFICER | Mar 15, 2025 | Mar 18, 2025 | M · derivative | 10,000 | $0.00 | $0 | 30,000 | No | Form 4 |
| Allan JonathanGENERAL COUNSEL & CORP SEC | Mar 15, 2025 | Mar 18, 2025 | M | 7,475 | $0.00 | $0 | 29,776 | No | Form 4 |
| Allan JonathanGENERAL COUNSEL & CORP SEC | Mar 15, 2025 | Mar 18, 2025 | M | 6,000 | $0.00 | $0 | 35,776 | No | Form 4 |
| Allan JonathanGENERAL COUNSEL & CORP SEC | Mar 15, 2025 | Mar 18, 2025 | M · derivative | 7,475 | $0.00 | $0 | 14,950 | No | Form 4 |
| Allan JonathanGENERAL COUNSEL & CORP SEC | Mar 15, 2025 | Mar 18, 2025 | M · derivative | 6,000 | $0.00 | $0 | 18,000 | No | Form 4 |
| Kaye Edward M. MDCEO | Dec 30, 2024 | Jan 2, 2025 | M | 35,000 | $0.60 | $21,000 | 96,885 | No | Form 4 |
| Kaye Edward M. MDCEO | Dec 30, 2024 | Jan 2, 2025 | M · derivative | 35,000 | $0.60 | $21,000 | 567,801 | No | Form 4 |
| Blue Horizon Enterprise Ltd | Dec 23, 2024 | Dec 27, 2024 | S | 2,000,000 | $11.50 | Sale −$23,000,000 | 6,906,181 | No | Form 4 |
| Kaye Edward M. MDCEO | Dec 9, 2024 | Dec 11, 2024 | S | 6,786 | $12.99 | Sale −$88,150 | 61,885 | No | Form 4 |
| Allan JonathanGENERAL COUNSEL & CORP SEC | Dec 9, 2024 | Dec 11, 2024 | S | 12,114 | $13.69 | Sale −$165,841 | 23,028 | Yes | Form 4 |
| Allan JonathanGENERAL COUNSEL & CORP SEC | Dec 9, 2024 | Dec 11, 2024 | S | 1,552 | $12.99 | Sale −$20,160 | 21,476 | Yes | Form 4 |
| Ticho BarryCHIEF MEDICAL OFFICER | Dec 9, 2024 | Dec 11, 2024 | S | 2,586 | $12.99 | Sale −$33,592 | 44,746 | No | Form 4 |
| Kaye Edward M. MDCEO | Dec 6, 2024 | Dec 10, 2024 | S | 6,170 | $12.78 | Sale −$78,853 | 68,671 | No | Form 4 |
| Allan JonathanGENERAL COUNSEL & CORP SEC | Dec 6, 2024 | Dec 10, 2024 | S | 9,696 | $12.78 | Sale −$123,915 | 35,142 | No | Form 4 |
| Ticho BarryCHIEF MEDICAL OFFICER | Dec 6, 2024 | Dec 10, 2024 | S | 13,945 | $12.78 | Sale −$178,217 | 47,332 | No | Form 4 |
| Kaye Edward M. MDCEO | Dec 3, 2024 | Dec 10, 20244/A | M | 26,250 | $0.00 | $0 | 74,841 | No | Form 4/A |
| Kaye Edward M. MDCEO | Dec 3, 2024 | Dec 10, 20244/A | A · derivative | 52,500 | $0.00 | $0 | 52,500 | No | Form 4/A |
| Kaye Edward M. MDCEO | Dec 3, 2024 | Dec 10, 20244/A | M · derivative | 26,250 | $0.00 | $0 | 26,250 | No | Form 4/A |
| Ticho BarryCHIEF MEDICAL OFFICER | Dec 3, 2024 | Dec 5, 2024 | M | 10,000 | $0.00 | $0 | 61,277 | No | Form 4 |
| Ticho BarryCHIEF MEDICAL OFFICER | Dec 3, 2024 | Dec 5, 2024 | A · derivative | 20,000 | $0.00 | $0 | 20,000 | No | Form 4 |
| Ticho BarryCHIEF MEDICAL OFFICER | Dec 3, 2024 | Dec 5, 2024 | M · derivative | 10,000 | $0.00 | $0 | 10,000 | No | Form 4 |
| Allan JonathanGENERAL COUNSEL & CORP SEC | Dec 3, 2024 | Dec 5, 2024 | M | 6,000 | $0.00 | $0 | 44,838 | No | Form 4 |
| Allan JonathanGENERAL COUNSEL & CORP SEC | Dec 3, 2024 | Dec 5, 2024 | A · derivative | 12,000 | $0.00 | $0 | 12,000 | No | Form 4 |
| Allan JonathanGENERAL COUNSEL & CORP SEC | Dec 3, 2024 | Dec 5, 2024 | M · derivative | 6,000 | $0.00 | $0 | 6,000 | No | Form 4 |
| Ticho BarryCHIEF MEDICAL OFFICER | Dec 2, 2024 | Dec 3, 2024 | M | 10,000 | $0.60 | $6,000 | 61,277 | Yes | Form 4 |
| Ticho BarryCHIEF MEDICAL OFFICER | Dec 2, 2024 | Dec 3, 2024 | S | 10,000 | $12.07 | Sale −$120,700 | 51,277 | Yes | Form 4 |
| Ticho BarryCHIEF MEDICAL OFFICER | Dec 2, 2024 | Dec 3, 2024 | M · derivative | 10,000 | $0.60 | $6,000 | not reported | Yes | Form 4 |
| Ticho BarryCHIEF MEDICAL OFFICER | Dec 1, 2024 | Dec 3, 2024 | M | 48,792 | $0.00 | $0 | 51,277 | Yes | Form 4 |
| Ticho BarryCHIEF MEDICAL OFFICER | Dec 1, 2024 | Dec 3, 2024 | M · derivative | 48,792 | $0.00 | $0 | 11,981 | Yes | Form 4 |
| Kaye Edward M. MDCEO | Dec 1, 2024 | Dec 3, 2024 | M | 21,591 | $0.00 | $0 | 48,591 | No | Form 4 |
| Kaye Edward M. MDCEO | Dec 1, 2024 | Dec 3, 2024 | M · derivative | 21,591 | $0.00 | $0 | 4,317 | No | Form 4 |
| Allan JonathanGENERAL COUNSEL & CORP SEC | Dec 1, 2024 | Dec 3, 2024 | M | 33,927 | $0.00 | $0 | 38,838 | No | Form 4 |
| Allan JonathanGENERAL COUNSEL & CORP SEC | Dec 1, 2024 | Dec 3, 2024 | M · derivative | 33,927 | $0.00 | $0 | 12,357 | No | Form 4 |
| Ticho BarryCHIEF MEDICAL OFFICER | Nov 1, 2024 | Nov 5, 2024 | M | 10,000 | $0.60 | $6,000 | 12,485 | Yes | Form 4 |
| Ticho BarryCHIEF MEDICAL OFFICER | Nov 1, 2024 | Nov 5, 2024 | S | 10,000 | $12.68 | Sale −$126,800 | 2,485 | Yes | Form 4 |
| Ticho BarryCHIEF MEDICAL OFFICER | Nov 1, 2024 | Nov 5, 2024 | M · derivative | 10,000 | $0.60 | $6,000 | 10,000 | Yes | Form 4 |
| Ticho BarryCHIEF MEDICAL OFFICER | Oct 1, 2024 | Oct 2, 2024 | M | 10,000 | $0.60 | $6,000 | 12,485 | Yes | Form 4 |
| Ticho BarryCHIEF MEDICAL OFFICER | Oct 1, 2024 | Oct 2, 2024 | S | 10,000 | $12.06 | Sale −$120,600 | 2,485 | Yes | Form 4 |
| Ticho BarryCHIEF MEDICAL OFFICER | Oct 1, 2024 | Oct 2, 2024 | M · derivative | 10,000 | $0.60 | $6,000 | 20,000 | Yes | Form 4 |
| Blue Horizon Enterprise Ltd | Sep 19, 2024 | Sep 23, 2024 | S | 1,937,500 | $14.05 | Sale −$27,221,875 | 8,906,181 | No | Form 4 |
| Ticho BarryCHIEF MEDICAL OFFICER | Sep 3, 2024 | Sep 5, 2024 | M | 10,000 | $0.60 | $6,000 | 12,485 | Yes | Form 4 |
| Ticho BarryCHIEF MEDICAL OFFICER | Sep 3, 2024 | Sep 5, 2024 | S | 9,400 | $14.92 | Sale −$140,248 | 3,085 | Yes | Form 4 |
| Ticho BarryCHIEF MEDICAL OFFICER | Sep 3, 2024 | Sep 5, 2024 | S | 600 | $15.41 | Sale −$9,246 | 2,485 | Yes | Form 4 |
| Ticho BarryCHIEF MEDICAL OFFICER | Sep 3, 2024 | Sep 5, 2024 | M · derivative | 10,000 | $0.60 | $6,000 | 30,000 | Yes | Form 4 |
| Ticho BarryCHIEF MEDICAL OFFICER | Aug 1, 2024 | Aug 5, 2024 | M | 10,000 | $0.60 | $6,000 | 12,485 | Yes | Form 4 |
| Ticho BarryCHIEF MEDICAL OFFICER | Aug 1, 2024 | Aug 5, 2024 | S | 10,000 | $14.58 | Sale −$145,800 | 2,485 | Yes | Form 4 |
| Ticho BarryCHIEF MEDICAL OFFICER | Aug 1, 2024 | Aug 5, 2024 | M · derivative | 10,000 | $0.60 | $6,000 | 40,000 | Yes | Form 4 |
| Nash Huw M.Chief Business Officer | Jul 2, 2024 | Jul 3, 2024 | S | 2,467 | $13.10 | Sale −$32,318 | 33 | Yes | Form 4 |
| Nash Huw M.Chief Business Officer | Jul 2, 2024 | Jul 3, 2024 | S | 33 | $13.90 | Sale −$459 | not reported | Yes | Form 4 |
| Ticho BarryCHIEF MEDICAL OFFICER | Jul 1, 2024 | Jul 3, 2024 | M | 10,000 | $0.60 | $6,000 | 12,485 | Yes | Form 4 |
| Ticho BarryCHIEF MEDICAL OFFICER | Jul 1, 2024 | Jul 3, 2024 | S | 10,000 | $13.75 | Sale −$137,500 | 2,485 | Yes | Form 4 |
| Ticho BarryCHIEF MEDICAL OFFICER | Jul 1, 2024 | Jul 3, 2024 | M · derivative | 10,000 | $0.60 | $6,000 | 50,000 | Yes | Form 4 |
| Krainer Adrian R. | Jun 5, 2024 | Jun 7, 2024 | A · derivative | 7,639 | $16.41 | $125,356 | 7,639 | No | Form 4 |
| Levin Arthur A | Jun 5, 2024 | Jun 7, 2024 | A · derivative | 7,639 | $16.41 | $125,356 | 7,639 | No | Form 4 |
| Tzianabos Arthur | Jun 5, 2024 | Jun 7, 2024 | A · derivative | 7,639 | $16.41 | $125,356 | 7,639 | No | Form 4 |
| Menzel Garry E | Jun 5, 2024 | Jun 7, 2024 | A · derivative | 7,639 | $16.41 | $125,356 | 7,639 | No | Form 4 |
| Smith Ian F | Jun 5, 2024 | Jun 7, 2024 | A · derivative | 7,639 | $16.41 | $125,356 | 7,639 | No | Form 4 |
| Smith Julie | Jun 5, 2024 | Jun 7, 2024 | A · derivative | 7,639 | $16.41 | $125,356 | 7,639 | No | Form 4 |
| Burstein Jennifer | Jun 5, 2024 | Jun 7, 2024 | A · derivative | 7,639 | $16.41 | $125,356 | 7,639 | No | Form 4 |
| Harrison Seth Loring | Jun 5, 2024 | Jun 7, 2024 | A · derivative | 7,639 | $16.41 | $125,356 | 7,639 | No | Form 4 |
| Tulipano Stephen JFormer CFO | Mar 27, 2024 | Jun 7, 2024 | A · derivative | 60,000 | $14.17 | $850,200 | 60,000 | No | Form 4 |
| Tulipano Stephen JFormer CFO | Mar 27, 2024 | Jun 7, 2024 | A · derivative | 40,000 | $0.00 | $0 | 40,000 | No | Form 4 |
| Allan JonathanGENERAL COUNSEL & CORP SEC | Mar 27, 2024 | Jun 7, 2024 | A · derivative | 36,000 | $14.17 | $510,120 | 36,000 | No | Form 4 |
| Allan JonathanGENERAL COUNSEL & CORP SEC | Mar 27, 2024 | Jun 7, 2024 | A · derivative | 24,000 | $0.00 | $0 | 24,000 | No | Form 4 |
| Ticho BarryCHIEF MEDICAL OFFICER | Mar 27, 2024 | Jun 7, 2024 | A · derivative | 60,000 | $14.17 | $850,200 | 60,000 | No | Form 4 |
| Ticho BarryCHIEF MEDICAL OFFICER | Mar 27, 2024 | Jun 7, 2024 | A · derivative | 40,000 | $0.00 | $0 | 40,000 | No | Form 4 |
| Nash Huw M.COO & CBO | Mar 27, 2024 | Jun 7, 2024 | A · derivative | 60,000 | $14.17 | $850,200 | 60,000 | No | Form 4 |
| Nash Huw M.COO & CBO | Mar 27, 2024 | Jun 7, 2024 | A · derivative | 40,000 | $0.00 | $0 | 40,000 | No | Form 4 |
| Kaye Edward M. MDCEO | Mar 27, 2024 | Jun 7, 2024 | A · derivative | 159,000 | $14.17 | $2,253,030 | 159,000 | No | Form 4 |
| Kaye Edward M. MDCEO | Mar 27, 2024 | Jun 7, 2024 | A · derivative | 105,000 | $0.00 | $0 | 105,000 | No | Form 4 |
| Ticho BarryCHIEF MEDICAL OFFICER | Jun 3, 2024 | Jun 5, 2024 | M | 10,000 | $0.60 | $6,000 | 12,485 | Yes | Form 4 |
| Ticho BarryCHIEF MEDICAL OFFICER | Jun 3, 2024 | Jun 5, 2024 | S | 9,897 | $15.21 | Sale −$150,533 | 2,588 | Yes | Form 4 |
| Ticho BarryCHIEF MEDICAL OFFICER | Jun 3, 2024 | Jun 5, 2024 | S | 103 | $15.78 | Sale −$1,625 | 2,485 | Yes | Form 4 |
| Ticho BarryCHIEF MEDICAL OFFICER | Jun 3, 2024 | Jun 5, 2024 | M · derivative | 10,000 | $0.60 | $6,000 | 60,000 | Yes | Form 4 |
| Allan JonathanGENERAL COUNSEL & CORP SEC | May 20, 2024 | May 22, 2024 | M | 8,599 | $7.07 | $60,795 | 11,197 | Yes | Form 4 |
| Allan JonathanGENERAL COUNSEL & CORP SEC | May 20, 2024 | May 22, 2024 | S | 8,599 | $15.04 | Sale −$129,329 | 2,598 | Yes | Form 4 |
| Allan JonathanGENERAL COUNSEL & CORP SEC | May 20, 2024 | May 22, 2024 | M · derivative | 8,599 | $7.07 | $60,795 | 25,801 | Yes | Form 4 |
| Kaye Edward M. MDCEO | May 20, 2024 | May 22, 2024 | S | 39,686 | $15.39 | Sale −$610,768 | 29,664 | Yes | Form 4 |
| Kaye Edward M. MDCEO | May 20, 2024 | May 22, 2024 | S | 2,664 | $16.05 | Sale −$42,757 | 27,000 | Yes | Form 4 |
| Nash Huw M.COO & CBO | May 20, 2024 | May 22, 2024 | M | 50,000 | $0.40 | $20,000 | 50,000 | Yes | Form 4 |
| Nash Huw M.COO & CBO | May 20, 2024 | May 22, 2024 | S | 50,000 | $15.39 | Sale −$769,500 | not reported | Yes | Form 4 |
| Nash Huw M.COO & CBO | May 20, 2024 | May 22, 2024 | M · derivative | 50,000 | $0.40 | $20,000 | 46,000 | Yes | Form 4 |
| Leggett ThomasChief Financial Officer | May 15, 2024 | May 17, 2024 | A · derivative | 396,200 | $14.13 | $5,598,306 | 396,200 | No | Form 4 |
| Ticho BarryCHIEF MEDICAL OFFICER | May 1, 2024 | May 3, 2024 | M | 10,000 | $0.60 | $6,000 | 12,485 | Yes | Form 4 |
| Ticho BarryCHIEF MEDICAL OFFICER | May 1, 2024 | May 3, 2024 | S | 10,000 | $11.37 | Sale −$113,700 | 2,485 | Yes | Form 4 |
| Ticho BarryCHIEF MEDICAL OFFICER | May 1, 2024 | May 3, 2024 | M · derivative | 10,000 | $0.60 | $6,000 | 70,000 | Yes | Form 4 |
| Blue Horizon Enterprise Ltd | Apr 17, 2024 | Apr 18, 2024 | S | 3,600,000 | $11.60 | Sale −$41,760,000 | 10,843,681 | No | Form 4 |
| Nash Huw M.COO & CBO | Apr 1, 2024 | Apr 3, 2024 | M | 50,000 | $0.40 | $20,000 | 61,329 | Yes | Form 4 |
| Nash Huw M.COO & CBO | Apr 1, 2024 | Apr 3, 2024 | S | 60,929 | $13.22 | Sale −$805,481 | 400 | Yes | Form 4 |
| Nash Huw M.COO & CBO | Apr 1, 2024 | Apr 3, 2024 | S | 400 | $13.61 | Sale −$5,444 | not reported | Yes | Form 4 |
| Nash Huw M.COO & CBO | Apr 1, 2024 | Apr 3, 2024 | M · derivative | 50,000 | $0.40 | $20,000 | 96,000 | Yes | Form 4 |
| Ticho BarryCHIEF MEDICAL OFFICER | Apr 1, 2024 | Apr 3, 2024 | M | 442 | $0.60 | $265 | 11,911 | Yes | Form 4 |
| Ticho BarryCHIEF MEDICAL OFFICER | Apr 1, 2024 | Apr 3, 2024 | S | 9,426 | $13.23 | Sale −$124,706 | 2,485 | Yes | Form 4 |
| Ticho BarryCHIEF MEDICAL OFFICER | Apr 1, 2024 | Apr 3, 2024 | M · derivative | 442 | $0.60 | $265 | 80,000 | Yes | Form 4 |
| Allan JonathanGENERAL COUNSEL & CORP SEC | Mar 28, 2024 | Apr 1, 2024 | S | 5,026 | $13.19 | Sale −$66,293 | 2,698 | Yes | Form 4 |
| Allan JonathanGENERAL COUNSEL & CORP SEC | Mar 28, 2024 | Apr 1, 2024 | S | 100 | $13.81 | Sale −$1,381 | 2,598 | Yes | Form 4 |
| Allan JonathanGENERAL COUNSEL & CORP SEC | Mar 19, 2024 | Mar 19, 2024 | S | 2,349 | $6.10 | Sale −$14,329 | 7,724 | No | Form 4 |
| Kaye Edward M. MDCEO | Mar 19, 2024 | Mar 19, 2024 | S | 11,150 | $6.10 | Sale −$68,015 | 69,350 | No | Form 4 |
| Nash Huw M.COO & CBO | Mar 19, 2024 | Mar 19, 2024 | S | 4,116 | $6.10 | Sale −$25,108 | 11,329 | No | Form 4 |
| Ticho BarryCHIEF MEDICAL OFFICER | Mar 19, 2024 | Mar 19, 2024 | S | 4,116 | $6.10 | Sale −$25,108 | 11,469 | No | Form 4 |
| Tulipano Stephen JCFO | Mar 19, 2024 | Mar 19, 2024 | S | 4,116 | $6.10 | Sale −$25,108 | 20,746 | No | Form 4 |
| Allan JonathanGENERAL COUNSEL & CORP SEC | Mar 15, 2024 | Mar 19, 2024 | M | 7,475 | $0.00 | $0 | 10,073 | No | Form 4 |
| Allan JonathanGENERAL COUNSEL & CORP SEC | Mar 15, 2024 | Mar 19, 2024 | M · derivative | 7,475 | $0.00 | $0 | 22,425 | No | Form 4 |
| Kaye Edward M. MDCEO | Mar 15, 2024 | Mar 19, 2024 | M | 35,500 | $0.00 | $0 | 80,500 | No | Form 4 |
| Kaye Edward M. MDCEO | Mar 15, 2024 | Mar 19, 2024 | M · derivative | 35,500 | $0.00 | $0 | 106,500 | No | Form 4 |
| Nash Huw M.COO & CBO | Mar 15, 2024 | Mar 19, 2024 | M | 13,100 | $0.00 | $0 | 15,445 | No | Form 4 |
| Nash Huw M.COO & CBO | Mar 15, 2024 | Mar 19, 2024 | M · derivative | 13,100 | $0.00 | $0 | 39,300 | No | Form 4 |
| Ticho BarryCHIEF MEDICAL OFFICER | Mar 15, 2024 | Mar 19, 2024 | M | 13,100 | $0.00 | $0 | 15,585 | No | Form 4 |
| Ticho BarryCHIEF MEDICAL OFFICER | Mar 15, 2024 | Mar 19, 2024 | M · derivative | 13,100 | $0.00 | $0 | 39,300 | No | Form 4 |
| Tulipano Stephen JCFO | Mar 15, 2024 | Mar 19, 2024 | M | 13,100 | $0.00 | $0 | 24,862 | No | Form 4 |
| Tulipano Stephen JCFO | Mar 15, 2024 | Mar 19, 2024 | M · derivative | 13,100 | $0.00 | $0 | 39,300 | No | Form 4 |
| Ticho BarryCHIEF MEDICAL OFFICER | Mar 1, 2024 | Mar 5, 2024 | M | 5,504 | $0.60 | $3,302 | 12,485 | Yes | Form 4 |
| Ticho BarryCHIEF MEDICAL OFFICER | Mar 1, 2024 | Mar 5, 2024 | S | 10,000 | $7.75 | Sale −$77,500 | 2,485 | Yes | Form 4 |
| Ticho BarryCHIEF MEDICAL OFFICER | Mar 1, 2024 | Mar 5, 2024 | M · derivative | 5,504 | $0.60 | $3,302 | 80,442 | Yes | Form 4 |
| Tzianabos Arthur | Feb 13, 2024 | Feb 15, 2024 | M | 31,739 | $2.19 | $69,508 | 31,739 | No | Form 4 |
| Tzianabos Arthur | Feb 13, 2024 | Feb 15, 2024 | M · derivative | 31,739 | $2.19 | $69,508 | not reported | No | Form 4 |
| Ticho BarryCHIEF MEDICAL OFFICER | Feb 1, 2024 | Feb 5, 2024 | S | 10,000 | $4.80 | Sale −$48,000 | 6,981 | Yes | Form 4 |
| Ticho BarryChief Medical Officer | Jan 2, 2024 | Jan 4, 2024 | S | 10,000 | $5.74 | Sale −$57,400 | 16,981 | Yes | Form 4 |
| Allan JonathanGeneral Counsel & Corp Sec | Dec 1, 2023 | Dec 5, 2023 | D · derivative | 65,000 | $59.84 | $3,889,600 | not reported | No | Form 4 |
| Allan JonathanGeneral Counsel & Corp Sec | Dec 1, 2023 | Dec 5, 2023 | D · derivative | 121,100 | $20.34 | $2,463,174 | not reported | No | Form 4 |
| Allan JonathanGeneral Counsel & Corp Sec | Dec 1, 2023 | Dec 5, 2023 | A · derivative | 46,284 | $0.00 | $0 | 46,284 | No | Form 4 |
| Kaye Edward M. MDCEO | Dec 1, 2023 | Dec 5, 2023 | D · derivative | 200,800 | $60.00 | $12,048,000 | not reported | No | Form 4 |
| Kaye Edward M. MDCEO | Dec 1, 2023 | Dec 5, 2023 | A · derivative | 25,908 | $0.00 | $0 | 25,908 | No | Form 4 |
| Nash Huw M.COO & CBO | Dec 1, 2023 | Dec 5, 2023 | D · derivative | 65,600 | $60.00 | $3,936,000 | not reported | No | Form 4 |
| Nash Huw M.COO & CBO | Dec 1, 2023 | Dec 5, 2023 | A · derivative | 8,463 | $0.00 | $0 | 8,463 | No | Form 4 |
| Ticho BarryChief Medical Officer | Dec 1, 2023 | Dec 5, 2023 | D · derivative | 60,000 | $20.25 | $1,215,000 | not reported | No | Form 4 |
| Ticho BarryChief Medical Officer | Dec 1, 2023 | Dec 5, 2023 | D · derivative | 65,600 | $60.00 | $3,936,000 | not reported | No | Form 4 |
| Ticho BarryChief Medical Officer | Dec 1, 2023 | Dec 5, 2023 | D · derivative | 107,400 | $20.34 | $2,184,516 | not reported | No | Form 4 |
| Ticho BarryChief Medical Officer | Dec 1, 2023 | Dec 5, 2023 | A · derivative | 60,773 | $0.00 | $0 | 60,773 | No | Form 4 |
| Tulipano Stephen JCFO | Dec 1, 2023 | Dec 5, 2023 | D · derivative | 60,000 | $20.25 | $1,215,000 | not reported | No | Form 4 |
| Tulipano Stephen JCFO | Dec 1, 2023 | Dec 5, 2023 | D · derivative | 65,600 | $60.00 | $3,936,000 | not reported | No | Form 4 |
| Tulipano Stephen JCFO | Dec 1, 2023 | Dec 5, 2023 | D · derivative | 107,400 | $20.34 | $2,184,516 | not reported | No | Form 4 |
| Tulipano Stephen JCFO | Dec 1, 2023 | Dec 5, 2023 | A · derivative | 60,773 | $0.00 | $0 | 60,773 | No | Form 4 |