TVTXTravere Therapeutics, Inc.
- Market cap
- $4.66B
- as of 2026-10-23
- Latest close
- $50.08
- as of 2026-10-23
- Sector
- Healthcare
- as of 2026-10-24
- Industry
- Biotechnology
- as of 2026-10-24
Cluster
No cluster in the last 90 days under the default rule (14d · ≥2 insiders · all roles).
Form 4 historysince 2023-10-04
Showing the latest 500 of 501 transactions.
| Insider | Traded | Filed | Type | Shares | Price | Value | Owned after | 10b5-1 plan | Filing |
|---|---|---|---|---|---|---|---|---|---|
| Dube Eric MCHIEF EXECUTIVE OFFICER | Oct 15 | Oct 19 | M | 43,735 | $26.88 | $1,175,597 | 476,621 | Yes | Form 4 |
| Dube Eric MCHIEF EXECUTIVE OFFICER | Oct 15 | Oct 19 | M | 200,000 | $8.93 | $1,786,000 | 676,621 | Yes | Form 4 |
| Dube Eric MCHIEF EXECUTIVE OFFICER | Oct 15 | Oct 19 | S | 128,065 | $52.97 | Sale −$6,783,244 | 548,556 | Yes | Form 4 |
| Dube Eric MCHIEF EXECUTIVE OFFICER | Oct 15 | Oct 19 | S | 37,270 | $54.20 | Sale −$2,020,023 | 511,286 | Yes | Form 4 |
| Dube Eric MCHIEF EXECUTIVE OFFICER | Oct 15 | Oct 19 | S | 78,400 | $55.02 | Sale −$4,313,403 | 432,886 | Yes | Form 4 |
| Dube Eric MCHIEF EXECUTIVE OFFICER | Oct 15 | Oct 19 | M · derivative | 43,735 | $26.88 | $1,175,597 | 168,925 | Yes | Form 4 |
| Dube Eric MCHIEF EXECUTIVE OFFICER | Oct 15 | Oct 19 | M · derivative | 200,000 | $8.93 | $1,786,000 | 160,000 | Yes | Form 4 |
| Dube Eric MCHIEF EXECUTIVE OFFICER | Sep 17 | Sep 17 | M | 108,493 | $23.34 | $2,532,227 | 541,379 | Yes | Form 4 |
| Dube Eric MCHIEF EXECUTIVE OFFICER | Sep 17 | Sep 17 | S | 101,691 | $64.59 | Sale −$6,568,222 | 439,688 | Yes | Form 4 |
| Dube Eric MCHIEF EXECUTIVE OFFICER | Sep 17 | Sep 17 | S | 6,802 | $64.95 | Sale −$441,790 | 432,886 | Yes | Form 4 |
| Dube Eric MCHIEF EXECUTIVE OFFICER | Sep 17 | Sep 17 | M · derivative | 108,493 | $23.34 | $2,532,227 | not reported | Yes | Form 4 |
| Heerma PeterEVP, CHIEF COMMERCIAL OFFICER | Sep 17 | Sep 17 | M | 8,282 | $22.40 | $185,517 | 125,348 | Yes | Form 4 |
| Heerma PeterEVP, CHIEF COMMERCIAL OFFICER | Sep 17 | Sep 17 | S | 8,282 | $65.07 | Sale −$538,910 | 117,066 | Yes | Form 4 |
| Heerma PeterEVP, CHIEF COMMERCIAL OFFICER | Sep 17 | Sep 17 | M · derivative | 8,282 | $22.40 | $185,517 | 44,837 | Yes | Form 4 |
| Rote William E.Chief Research Officer | Sep 16 | Sep 17 | M | 350 | $17.96 | $6,286 | 98,547 | Yes | Form 4 |
| Rote William E.Chief Research Officer | Sep 16 | Sep 17 | M | 55,000 | $15.46 | $850,300 | 153,547 | Yes | Form 4 |
| Rote William E.Chief Research Officer | Sep 16 | Sep 17 | M | 57,500 | $26.88 | $1,545,600 | 211,047 | Yes | Form 4 |
| Rote William E.Chief Research Officer | Sep 16 | Sep 17 | S | 65,104 | $63.12 | Sale −$4,109,364 | 145,943 | Yes | Form 4 |
| Rote William E.Chief Research Officer | Sep 16 | Sep 17 | S | 47,746 | $63.61 | Sale −$3,037,123 | 98,197 | Yes | Form 4 |
| Rote William E.Chief Research Officer | Sep 16 | Sep 17 | M · derivative | 350 | $17.96 | $6,286 | not reported | Yes | Form 4 |
| Rote William E.Chief Research Officer | Sep 16 | Sep 17 | M · derivative | 55,000 | $15.46 | $850,300 | not reported | Yes | Form 4 |
| Rote William E.Chief Research Officer | Sep 16 | Sep 17 | M · derivative | 57,500 | $26.88 | $1,545,600 | not reported | Yes | Form 4 |
| Dube Eric MCHIEF EXECUTIVE OFFICER | Sep 16 | Sep 17 | M | 195,841 | $23.34 | $4,570,929 | 628,727 | Yes | Form 4 |
| Dube Eric MCHIEF EXECUTIVE OFFICER | Sep 16 | Sep 17 | S | 99,716 | $63.26 | Sale −$6,308,034 | 529,011 | Yes | Form 4 |
| Dube Eric MCHIEF EXECUTIVE OFFICER | Sep 16 | Sep 17 | S | 96,125 | $63.64 | Sale −$6,117,395 | 432,886 | Yes | Form 4 |
| Dube Eric MCHIEF EXECUTIVE OFFICER | Sep 16 | Sep 17 | M · derivative | 195,841 | $23.34 | $4,570,929 | 108,493 | Yes | Form 4 |
| Heerma PeterEVP, CHIEF COMMERCIAL OFFICER | Sep 16 | Sep 17 | M | 100,000 | $11.25 | $1,125,000 | 217,066 | Yes | Form 4 |
| Heerma PeterEVP, CHIEF COMMERCIAL OFFICER | Sep 16 | Sep 17 | M | 55,000 | $15.46 | $850,300 | 272,066 | Yes | Form 4 |
| Heerma PeterEVP, CHIEF COMMERCIAL OFFICER | Sep 16 | Sep 17 | M | 17,717 | $26.88 | $476,233 | 289,783 | Yes | Form 4 |
| Heerma PeterEVP, CHIEF COMMERCIAL OFFICER | Sep 16 | Sep 17 | S | 93,604 | $63.25 | Sale −$5,920,453 | 196,179 | Yes | Form 4 |
| Heerma PeterEVP, CHIEF COMMERCIAL OFFICER | Sep 16 | Sep 17 | S | 79,113 | $63.65 | Sale −$5,035,542 | 117,066 | Yes | Form 4 |
| Heerma PeterEVP, CHIEF COMMERCIAL OFFICER | Sep 16 | Sep 17 | M · derivative | 100,000 | $11.25 | $1,125,000 | not reported | Yes | Form 4 |
| Heerma PeterEVP, CHIEF COMMERCIAL OFFICER | Sep 16 | Sep 17 | M · derivative | 55,000 | $15.46 | $850,300 | not reported | Yes | Form 4 |
| Heerma PeterEVP, CHIEF COMMERCIAL OFFICER | Sep 16 | Sep 17 | M · derivative | 17,717 | $26.88 | $476,233 | 500 | Yes | Form 4 |
| Reed Elizabeth EChief Legal Officer and GC | Sep 15 | Sep 17 | M | 37,500 | $15.46 | $579,750 | 142,889 | Yes | Form 4 |
| Reed Elizabeth EChief Legal Officer and GC | Sep 15 | Sep 17 | S | 21,926 | $62.03 | Sale −$1,360,070 | 120,963 | Yes | Form 4 |
| Reed Elizabeth EChief Legal Officer and GC | Sep 15 | Sep 17 | S | 13,874 | $62.63 | Sale −$868,929 | 107,089 | Yes | Form 4 |
| Reed Elizabeth EChief Legal Officer and GC | Sep 15 | Sep 17 | S | 1,400 | $63.69 | Sale −$89,166 | 105,689 | Yes | Form 4 |
| Reed Elizabeth EChief Legal Officer and GC | Sep 15 | Sep 17 | S | 300 | $65.31 | Sale −$19,593 | 105,389 | Yes | Form 4 |
| Reed Elizabeth EChief Legal Officer and GC | Sep 15 | Sep 17 | M · derivative | 37,500 | $15.46 | $579,750 | not reported | Yes | Form 4 |
| Rote William E.Chief Research Officer | Sep 15 | Sep 17 | M | 39,000 | $25.25 | $984,750 | 154,745 | Yes | Form 4 |
| Rote William E.Chief Research Officer | Sep 15 | Sep 17 | M | 39,650 | $17.96 | $712,114 | 194,395 | Yes | Form 4 |
| Rote William E.Chief Research Officer | Sep 15 | Sep 17 | S | 63,907 | $61.99 | Sale −$3,961,595 | 130,488 | Yes | Form 4 |
| Rote William E.Chief Research Officer | Sep 15 | Sep 17 | S | 29,021 | $62.66 | Sale −$1,818,456 | 101,467 | Yes | Form 4 |
| Rote William E.Chief Research Officer | Sep 15 | Sep 17 | S | 3,000 | $63.65 | Sale −$190,950 | 98,467 | Yes | Form 4 |
| Rote William E.Chief Research Officer | Sep 15 | Sep 17 | S | 270 | $65.31 | Sale −$17,634 | 98,197 | Yes | Form 4 |
| Rote William E.Chief Research Officer | Sep 15 | Sep 17 | M · derivative | 39,000 | $25.25 | $984,750 | not reported | Yes | Form 4 |
| Rote William E.Chief Research Officer | Sep 15 | Sep 17 | M · derivative | 39,650 | $17.96 | $712,114 | 350 | Yes | Form 4 |
| Dube Eric MCHIEF EXECUTIVE OFFICER | Sep 15 | Sep 17 | M | 95,666 | $23.34 | $2,232,844 | 528,552 | Yes | Form 4 |
| Dube Eric MCHIEF EXECUTIVE OFFICER | Sep 15 | Sep 17 | S | 63,498 | $61.99 | Sale −$3,936,241 | 465,054 | Yes | Form 4 |
| Dube Eric MCHIEF EXECUTIVE OFFICER | Sep 15 | Sep 17 | S | 28,796 | $62.66 | Sale −$1,804,357 | 436,258 | Yes | Form 4 |
| Dube Eric MCHIEF EXECUTIVE OFFICER | Sep 15 | Sep 17 | S | 3,102 | $63.64 | Sale −$197,411 | 433,156 | Yes | Form 4 |
| Dube Eric MCHIEF EXECUTIVE OFFICER | Sep 15 | Sep 17 | S | 270 | $65.31 | Sale −$17,634 | 432,886 | Yes | Form 4 |
| Dube Eric MCHIEF EXECUTIVE OFFICER | Sep 15 | Sep 17 | M · derivative | 95,666 | $23.34 | $2,232,844 | 304,334 | Yes | Form 4 |
| Heerma PeterEVP, CHIEF COMMERCIAL OFFICER | Sep 15 | Sep 17 | M | 39,283 | $26.88 | $1,055,927 | 181,349 | Yes | Form 4 |
| Heerma PeterEVP, CHIEF COMMERCIAL OFFICER | Sep 15 | Sep 17 | M | 1,381 | $22.40 | $30,934 | 182,730 | Yes | Form 4 |
| Heerma PeterEVP, CHIEF COMMERCIAL OFFICER | Sep 15 | Sep 17 | M | 36,526 | $8.93 | $326,177 | 219,256 | Yes | Form 4 |
| Heerma PeterEVP, CHIEF COMMERCIAL OFFICER | Sep 15 | Sep 17 | S | 71,938 | $62.05 | Sale −$4,463,753 | 147,318 | Yes | Form 4 |
| Heerma PeterEVP, CHIEF COMMERCIAL OFFICER | Sep 15 | Sep 17 | S | 27,421 | $62.59 | Sale −$1,716,280 | 119,897 | Yes | Form 4 |
| Heerma PeterEVP, CHIEF COMMERCIAL OFFICER | Sep 15 | Sep 17 | S | 1,400 | $63.65 | Sale −$89,110 | 118,497 | Yes | Form 4 |
| Heerma PeterEVP, CHIEF COMMERCIAL OFFICER | Sep 15 | Sep 17 | S | 1,431 | $65.31 | Sale −$93,459 | 117,066 | Yes | Form 4 |
| Heerma PeterEVP, CHIEF COMMERCIAL OFFICER | Sep 15 | Sep 17 | M · derivative | 39,283 | $26.88 | $1,055,927 | 18,217 | Yes | Form 4 |
| Heerma PeterEVP, CHIEF COMMERCIAL OFFICER | Sep 15 | Sep 17 | M · derivative | 1,381 | $22.40 | $30,934 | 53,119 | Yes | Form 4 |
| Heerma PeterEVP, CHIEF COMMERCIAL OFFICER | Sep 15 | Sep 17 | M · derivative | 36,526 | $8.93 | $326,177 | 28,474 | Yes | Form 4 |
| Calvin SandraSVP, CHIEF ACCOUNTING OFFICER | Sep 15 | Sep 17 | M | 2,500 | $27.50 | $68,750 | 44,853 | Yes | Form 4 |
| Calvin SandraSVP, CHIEF ACCOUNTING OFFICER | Sep 15 | Sep 17 | M | 1,250 | $22.40 | $28,000 | 46,103 | Yes | Form 4 |
| Calvin SandraSVP, CHIEF ACCOUNTING OFFICER | Sep 15 | Sep 17 | M | 1,625 | $20.46 | $33,248 | 47,728 | Yes | Form 4 |
| Calvin SandraSVP, CHIEF ACCOUNTING OFFICER | Sep 15 | Sep 17 | S | 4,275 | $62.14 | Sale −$265,649 | 43,453 | Yes | Form 4 |
| Calvin SandraSVP, CHIEF ACCOUNTING OFFICER | Sep 15 | Sep 17 | S | 800 | $62.85 | Sale −$50,280 | 42,653 | Yes | Form 4 |
| Calvin SandraSVP, CHIEF ACCOUNTING OFFICER | Sep 15 | Sep 17 | S | 300 | $63.66 | Sale −$19,098 | 42,353 | Yes | Form 4 |
| Calvin SandraSVP, CHIEF ACCOUNTING OFFICER | Sep 15 | Sep 17 | M · derivative | 2,500 | $27.50 | $68,750 | not reported | Yes | Form 4 |
| Calvin SandraSVP, CHIEF ACCOUNTING OFFICER | Sep 15 | Sep 17 | M · derivative | 1,250 | $22.40 | $28,000 | 3,750 | Yes | Form 4 |
| Calvin SandraSVP, CHIEF ACCOUNTING OFFICER | Sep 15 | Sep 17 | M · derivative | 1,625 | $20.46 | $33,248 | 17,875 | Yes | Form 4 |
| Inrig JulaEVP, Head of R&D & CMO | Sep 15 | Sep 17 | M | 32,395 | $8.93 | $289,287 | 145,165 | Yes | Form 4 |
| Inrig JulaEVP, Head of R&D & CMO | Sep 15 | Sep 17 | S | 25,390 | $62.02 | Sale −$1,574,688 | 119,775 | Yes | Form 4 |
| Inrig JulaEVP, Head of R&D & CMO | Sep 15 | Sep 17 | S | 17,284 | $62.62 | Sale −$1,082,324 | 102,491 | Yes | Form 4 |
| Inrig JulaEVP, Head of R&D & CMO | Sep 15 | Sep 17 | S | 1,600 | $63.69 | Sale −$101,904 | 100,891 | Yes | Form 4 |
| Inrig JulaEVP, Head of R&D & CMO | Sep 15 | Sep 17 | S | 400 | $65.31 | Sale −$26,124 | 100,491 | Yes | Form 4 |
| Inrig JulaEVP, Head of R&D & CMO | Sep 15 | Sep 17 | M · derivative | 32,395 | $8.93 | $289,287 | 43,605 | Yes | Form 4 |
| Cline Christopher R.CHIEF FINANCIAL OFFICER | Sep 15 | Sep 17 | M | 20,000 | $17.44 | $348,800 | 138,016 | Yes | Form 4 |
| Cline Christopher R.CHIEF FINANCIAL OFFICER | Sep 15 | Sep 17 | S | 27,473 | $62.00 | Sale −$1,703,326 | 110,543 | Yes | Form 4 |
| Cline Christopher R.CHIEF FINANCIAL OFFICER | Sep 15 | Sep 17 | S | 20,735 | $62.61 | Sale −$1,298,218 | 89,808 | Yes | Form 4 |
| Cline Christopher R.CHIEF FINANCIAL OFFICER | Sep 15 | Sep 17 | S | 1,900 | $63.69 | Sale −$121,011 | 87,908 | Yes | Form 4 |
| Cline Christopher R.CHIEF FINANCIAL OFFICER | Sep 15 | Sep 17 | S | 400 | $65.31 | Sale −$26,124 | 87,508 | Yes | Form 4 |
| Cline Christopher R.CHIEF FINANCIAL OFFICER | Sep 15 | Sep 17 | M · derivative | 20,000 | $17.44 | $348,800 | not reported | Yes | Form 4 |
| Meckler Jeffrey A | Sep 10 | Sep 11 | M | 10,000 | $17.44 | $174,400 | 101,500 | Yes | Form 4 |
| Meckler Jeffrey A | Sep 10 | Sep 11 | M | 10,000 | $26.52 | $265,200 | 111,500 | Yes | Form 4 |
| Meckler Jeffrey A | Sep 10 | Sep 11 | S | 1,700 | $65.39 | Sale −$111,163 | 109,800 | Yes | Form 4 |
| Meckler Jeffrey A | Sep 10 | Sep 11 | S | 1,200 | $66.15 | Sale −$79,380 | 108,600 | Yes | Form 4 |
| Meckler Jeffrey A | Sep 10 | Sep 11 | S | 14,000 | $67.46 | Sale −$944,440 | 94,600 | Yes | Form 4 |
| Meckler Jeffrey A | Sep 10 | Sep 11 | S | 3,100 | $68.09 | Sale −$211,079 | 91,500 | Yes | Form 4 |
| Meckler Jeffrey A | Sep 10 | Sep 11 | M · derivative | 10,000 | $17.44 | $174,400 | not reported | Yes | Form 4 |
| Meckler Jeffrey A | Sep 10 | Sep 11 | M · derivative | 10,000 | $26.52 | $265,200 | not reported | Yes | Form 4 |
| Cline Christopher R.CHIEF FINANCIAL OFFICER | Sep 2 | Sep 3 | S | 642 | $66.37 | Sale −$42,610 | 118,016 | No | Form 4 |
| Lyons Gary A | Aug 18 | Aug 19 | M | 5,000 | $17.44 | $87,200 | 66,500 | Yes | Form 4 |
| Lyons Gary A | Aug 18 | Aug 19 | S | 4,100 | $63.27 | Sale −$259,407 | 62,400 | Yes | Form 4 |
| Lyons Gary A | Aug 18 | Aug 19 | S | 900 | $63.86 | Sale −$57,474 | 61,500 | Yes | Form 4 |
| Lyons Gary A | Aug 18 | Aug 19 | M · derivative | 5,000 | $17.44 | $87,200 | not reported | Yes | Form 4 |
| Lyons Gary A | Aug 17 | Aug 19 | M | 5,000 | $17.44 | $87,200 | 66,500 | Yes | Form 4 |
| Lyons Gary A | Aug 17 | Aug 19 | S | 1,900 | $62.53 | Sale −$118,807 | 64,600 | Yes | Form 4 |
| Lyons Gary A | Aug 17 | Aug 19 | S | 2,600 | $63.50 | Sale −$165,100 | 62,000 | Yes | Form 4 |
| Lyons Gary A | Aug 17 | Aug 19 | S | 500 | $64.16 | Sale −$32,080 | 61,500 | Yes | Form 4 |
| Lyons Gary A | Aug 17 | Aug 19 | M · derivative | 5,000 | $17.44 | $87,200 | 5,000 | Yes | Form 4 |
| Inrig JulaCHIEF MEDICAL OFFICER | Jun 22 | Jun 22 | G | 468 | $0.00 | $0 | 112,770 | No | Form 4 |
| Coughlin Timothy | Jun 12 | Jun 16 | M | 10,000 | $26.52 | $265,200 | 66,250 | Yes | Form 4 |
| Coughlin Timothy | Jun 12 | Jun 16 | S | 10,000 | $50.07 | Sale −$500,700 | 56,250 | Yes | Form 4 |
| Coughlin Timothy | Jun 12 | Jun 16 | M · derivative | 10,000 | $26.52 | $265,200 | not reported | Yes | Form 4 |
| Baynes Roy D. | Jun 12 | Jun 16 | M | 4,500 | $21.38 | $96,210 | 46,000 | Yes | Form 4 |
| Baynes Roy D. | Jun 12 | Jun 16 | S | 4,500 | $50.00 | Sale −$225,000 | 41,500 | Yes | Form 4 |
| Baynes Roy D. | Jun 12 | Jun 16 | M · derivative | 4,500 | $21.38 | $96,210 | not reported | Yes | Form 4 |
| Lyons Gary A | May 19 | May 21 | A | 4,000 | $0.00 | $0 | 61,500 | No | Form 4 |
| Lyons Gary A | May 19 | May 21 | A · derivative | 12,000 | $42.26 | $507,120 | 12,000 | No | Form 4 |
| Williams Brinkley Ruth | May 19 | May 21 | A | 4,000 | $0.00 | $0 | 29,750 | No | Form 4 |
| Williams Brinkley Ruth | May 19 | May 21 | A · derivative | 12,000 | $42.26 | $507,120 | 12,000 | No | Form 4 |
| Coughlin Timothy | May 19 | May 21 | A | 4,000 | $0.00 | $0 | 56,250 | No | Form 4 |
| Coughlin Timothy | May 19 | May 21 | A · derivative | 12,000 | $42.26 | $507,120 | 12,000 | No | Form 4 |
| Squarer Ron | May 19 | May 21 | A | 4,000 | $0.00 | $0 | 39,375 | No | Form 4 |
| Squarer Ron | May 19 | May 21 | A · derivative | 12,000 | $42.26 | $507,120 | 12,000 | No | Form 4 |
| Orwin John A | May 19 | May 21 | A | 4,000 | $0.00 | $0 | 39,375 | No | Form 4 |
| Orwin John A | May 19 | May 21 | A · derivative | 12,000 | $42.26 | $507,120 | 12,000 | No | Form 4 |
| Meckler Jeffrey A | May 19 | May 21 | A | 4,000 | $0.00 | $0 | 91,500 | No | Form 4 |
| Meckler Jeffrey A | May 19 | May 21 | A · derivative | 12,000 | $42.26 | $507,120 | 12,000 | No | Form 4 |
| Bruhn Suzanne Louise | May 19 | May 21 | A | 4,000 | $0.00 | $0 | 32,750 | No | Form 4 |
| Bruhn Suzanne Louise | May 19 | May 21 | A · derivative | 12,000 | $42.26 | $507,120 | 12,000 | No | Form 4 |
| Poole Sandra | May 19 | May 21 | A | 4,000 | $0.00 | $0 | 34,000 | No | Form 4 |
| Poole Sandra | May 19 | May 21 | A · derivative | 12,000 | $42.26 | $507,120 | 12,000 | No | Form 4 |
| Baynes Roy D. | May 19 | May 21 | A | 4,000 | $0.00 | $0 | 41,500 | No | Form 4 |
| Baynes Roy D. | May 19 | May 21 | A · derivative | 12,000 | $42.26 | $507,120 | 12,000 | No | Form 4 |
| Coughlin Timothy | May 15 | May 19 | S | 3,250 | $43.49 | Sale −$141,343 | 52,250 | Yes | Form 4 |
| Reed Elizabeth EChief Legal Officer and GC | May 6 | May 6 | S | 2,076 | $43.95 | Sale −$91,240 | 105,211 | Yes | Form 4 |
| Rote William E.Chief Research Officer | May 6 | May 6 | S | 2,763 | $43.95 | Sale −$121,434 | 115,474 | Yes | Form 4 |
| Dube Eric MCHIEF EXECUTIVE OFFICER | May 6 | May 6 | S | 22,500 | $43.95 | Sale −$988,875 | 432,886 | Yes | Form 4 |
| Inrig JulaCHIEF MEDICAL OFFICER | May 6 | May 6 | S | 311 | $43.95 | Sale −$13,668 | 113,238 | Yes | Form 4 |
| Cline Christopher R.CHIEF FINANCIAL OFFICER | May 6 | May 6 | S | 310 | $43.95 | Sale −$13,625 | 118,658 | Yes | Form 4 |
| Reed Elizabeth EChief Legal Officer and GC | May 5 | May 6 | S | 2,174 | $46.65 | Sale −$101,417 | 107,287 | Yes | Form 4 |
| Baynes Roy D. | May 5 | May 6 | M | 4,500 | $18.27 | $82,215 | 42,000 | Yes | Form 4 |
| Baynes Roy D. | May 5 | May 6 | S | 4,500 | $46.65 | Sale −$209,925 | 37,500 | Yes | Form 4 |
| Baynes Roy D. | May 5 | May 6 | M · derivative | 4,500 | $18.27 | $82,215 | not reported | Yes | Form 4 |
| Heerma PeterCHIEF COMMERCIAL OFFICER | May 5 | May 6 | S | 2,174 | $46.65 | Sale −$101,417 | 140,684 | No | Form 4 |
| Inrig JulaCHIEF MEDICAL OFFICER | May 5 | May 6 | S | 2,174 | $46.65 | Sale −$101,417 | 113,549 | Yes | Form 4 |
| Cline Christopher R.CHIEF FINANCIAL OFFICER | May 5 | May 6 | S | 2,181 | $46.65 | Sale −$101,744 | 118,968 | Yes | Form 4 |
| Reed Elizabeth EChief Legal Officer and GC | May 4 | May 6 | M | 20,000 | $17.96 | $359,200 | 125,211 | Yes | Form 4 |
| Reed Elizabeth EChief Legal Officer and GC | May 4 | May 6 | S | 20,000 | $45.00 | Sale −$900,000 | 105,211 | Yes | Form 4 |
| Reed Elizabeth EChief Legal Officer and GC | May 4 | May 6 | M | 4,250 | $0.00 | $0 | 109,461 | Yes | Form 4 |
| Reed Elizabeth EChief Legal Officer and GC | May 4 | May 6 | M · derivative | 20,000 | $17.96 | $359,200 | not reported | Yes | Form 4 |
| Reed Elizabeth EChief Legal Officer and GC | May 4 | May 6 | A · derivative | 8,500 | $0.00 | $0 | 8,500 | Yes | Form 4 |
| Reed Elizabeth EChief Legal Officer and GC | May 4 | May 6 | M · derivative | 4,250 | $0.00 | $0 | 4,250 | Yes | Form 4 |
| Meckler Jeffrey A | May 4 | May 6 | M | 8,000 | $16.33 | $130,640 | 95,500 | Yes | Form 4 |
| Meckler Jeffrey A | May 4 | May 6 | S | 8,000 | $45.00 | Sale −$360,000 | 87,500 | Yes | Form 4 |
| Meckler Jeffrey A | May 4 | May 6 | M · derivative | 8,000 | $16.33 | $130,640 | not reported | Yes | Form 4 |
| Rote William E.Chief Research Officer | May 4 | May 6 | M | 4,250 | $0.00 | $0 | 118,237 | Yes | Form 4 |
| Rote William E.Chief Research Officer | May 4 | May 6 | A · derivative | 8,500 | $0.00 | $0 | 8,500 | Yes | Form 4 |
| Rote William E.Chief Research Officer | May 4 | May 6 | M · derivative | 4,250 | $0.00 | $0 | 4,250 | Yes | Form 4 |
| Dube Eric MCHIEF EXECUTIVE OFFICER | May 4 | May 6 | M | 22,500 | $0.00 | $0 | 455,386 | Yes | Form 4 |
| Dube Eric MCHIEF EXECUTIVE OFFICER | May 4 | May 6 | A · derivative | 45,000 | $0.00 | $0 | 45,000 | Yes | Form 4 |
| Dube Eric MCHIEF EXECUTIVE OFFICER | May 4 | May 6 | M · derivative | 22,500 | $0.00 | $0 | 22,500 | Yes | Form 4 |
| Heerma PeterCHIEF COMMERCIAL OFFICER | May 4 | May 6 | M | 4,250 | $0.00 | $0 | 142,858 | No | Form 4 |
| Heerma PeterCHIEF COMMERCIAL OFFICER | May 4 | May 6 | A · derivative | 8,500 | $0.00 | $0 | 8,500 | No | Form 4 |
| Heerma PeterCHIEF COMMERCIAL OFFICER | May 4 | May 6 | M · derivative | 4,250 | $0.00 | $0 | 4,250 | No | Form 4 |
| Inrig JulaCHIEF MEDICAL OFFICER | May 4 | May 6 | M | 20,000 | $22.40 | $448,000 | 131,473 | Yes | Form 4 |
| Inrig JulaCHIEF MEDICAL OFFICER | May 4 | May 6 | S | 20,000 | $45.00 | Sale −$900,000 | 111,473 | Yes | Form 4 |
| Inrig JulaCHIEF MEDICAL OFFICER | May 4 | May 6 | M | 4,250 | $0.00 | $0 | 115,723 | Yes | Form 4 |
| Inrig JulaCHIEF MEDICAL OFFICER | May 4 | May 6 | M · derivative | 20,000 | $22.40 | $448,000 | 34,500 | Yes | Form 4 |
| Inrig JulaCHIEF MEDICAL OFFICER | May 4 | May 6 | A · derivative | 8,500 | $0.00 | $0 | 8,500 | Yes | Form 4 |
| Inrig JulaCHIEF MEDICAL OFFICER | May 4 | May 6 | M · derivative | 4,250 | $0.00 | $0 | 4,250 | Yes | Form 4 |
| Cline Christopher R.CHIEF FINANCIAL OFFICER | May 4 | May 6 | M | 4,250 | $0.00 | $0 | 121,149 | Yes | Form 4 |
| Cline Christopher R.CHIEF FINANCIAL OFFICER | May 4 | May 6 | A · derivative | 8,500 | $0.00 | $0 | 8,500 | Yes | Form 4 |
| Cline Christopher R.CHIEF FINANCIAL OFFICER | May 4 | May 6 | M · derivative | 4,250 | $0.00 | $0 | 4,250 | Yes | Form 4 |
| Baynes Roy D. | May 1 | May 4 | M | 9,750 | $6.82 | $66,495 | 47,250 | Yes | Form 4 |
| Baynes Roy D. | May 1 | May 4 | S | 9,750 | $44.22 | Sale −$431,145 | 37,500 | Yes | Form 4 |
| Baynes Roy D. | May 1 | May 4 | M · derivative | 9,750 | $6.82 | $66,495 | 9,750 | Yes | Form 4 |
| Rote William E.Chief Research Officer | Apr 22 | Apr 23 | S | 9,100 | $39.09 | Sale −$355,719 | 113,987 | Yes | Form 4 |
| Lyons Gary A | Apr 14 | Apr 16 | M | 8,000 | $16.33 | $130,640 | 65,500 | Yes | Form 4 |
| Lyons Gary A | Apr 14 | Apr 16 | S | 8,000 | $41.07 | Sale −$328,560 | 57,500 | Yes | Form 4 |
| Lyons Gary A | Apr 14 | Apr 16 | M · derivative | 8,000 | $16.33 | $130,640 | not reported | Yes | Form 4 |
| Baynes Roy D. | Apr 14 | Apr 16 | M | 8,000 | $17.94 | $143,520 | 45,500 | Yes | Form 4 |
| Baynes Roy D. | Apr 14 | Apr 16 | M | 9,000 | $15.43 | $138,870 | 54,500 | Yes | Form 4 |
| Baynes Roy D. | Apr 14 | Apr 16 | M | 4,500 | $18.27 | $82,215 | 59,000 | Yes | Form 4 |
| Baynes Roy D. | Apr 14 | Apr 16 | M | 4,500 | $21.38 | $96,210 | 63,500 | Yes | Form 4 |
| Baynes Roy D. | Apr 14 | Apr 16 | M | 6,750 | $17.11 | $115,493 | 70,250 | Yes | Form 4 |
| Baynes Roy D. | Apr 14 | Apr 16 | S | 26,000 | $41.07 | Sale −$1,067,820 | 44,250 | Yes | Form 4 |
| Baynes Roy D. | Apr 14 | Apr 16 | S | 6,750 | $42.12 | Sale −$284,310 | 37,500 | Yes | Form 4 |
| Baynes Roy D. | Apr 14 | Apr 16 | M · derivative | 8,000 | $17.94 | $143,520 | not reported | Yes | Form 4 |
| Baynes Roy D. | Apr 14 | Apr 16 | M · derivative | 9,000 | $15.43 | $138,870 | not reported | Yes | Form 4 |
| Baynes Roy D. | Apr 14 | Apr 16 | M · derivative | 4,500 | $18.27 | $82,215 | 4,500 | Yes | Form 4 |
| Baynes Roy D. | Apr 14 | Apr 16 | M · derivative | 4,500 | $21.38 | $96,210 | 4,500 | Yes | Form 4 |
| Baynes Roy D. | Apr 14 | Apr 16 | M · derivative | 6,750 | $17.11 | $115,493 | 6,750 | Yes | Form 4 |
| Calvin SandraSVP, CHIEF ACCOUNTING OFFICER | Apr 14 | Apr 16 | M | 2,500 | $22.40 | $56,000 | 51,580 | Yes | Form 4 |
| Calvin SandraSVP, CHIEF ACCOUNTING OFFICER | Apr 14 | Apr 16 | M | 6,250 | $8.93 | $55,813 | 57,830 | Yes | Form 4 |
| Calvin SandraSVP, CHIEF ACCOUNTING OFFICER | Apr 14 | Apr 16 | M | 6,500 | $20.46 | $132,990 | 64,330 | Yes | Form 4 |
| Calvin SandraSVP, CHIEF ACCOUNTING OFFICER | Apr 14 | Apr 16 | S | 21,977 | $41.07 | Sale −$902,595 | 42,353 | Yes | Form 4 |
| Calvin SandraSVP, CHIEF ACCOUNTING OFFICER | Apr 14 | Apr 16 | M · derivative | 2,500 | $22.40 | $56,000 | 5,000 | Yes | Form 4 |
| Calvin SandraSVP, CHIEF ACCOUNTING OFFICER | Apr 14 | Apr 16 | M · derivative | 6,250 | $8.93 | $55,813 | 12,500 | Yes | Form 4 |
| Calvin SandraSVP, CHIEF ACCOUNTING OFFICER | Apr 14 | Apr 16 | M · derivative | 6,500 | $20.46 | $132,990 | 19,500 | Yes | Form 4 |
| Reed Elizabeth EChief Legal Officer and GC | Apr 15 | Apr 15 | S | 5,226 | $41.62 | Sale −$217,506 | 106,770 | Yes | Form 4 |
| Reed Elizabeth EChief Legal Officer and GC | Apr 15 | Apr 15 | S | 1,559 | $42.53 | Sale −$66,304 | 105,211 | Yes | Form 4 |
| Dube Eric MCHIEF EXECUTIVE OFFICER | Apr 15 | Apr 15 | S | 56,815 | $41.01 | Sale −$2,329,983 | 440,071 | Yes | Form 4 |
| Dube Eric MCHIEF EXECUTIVE OFFICER | Apr 15 | Apr 15 | S | 7,165 | $41.75 | Sale −$299,139 | 432,906 | Yes | Form 4 |
| Dube Eric MCHIEF EXECUTIVE OFFICER | Apr 15 | Apr 15 | S | 20 | $42.66 | Sale −$853 | 432,886 | Yes | Form 4 |
| Inrig JulaCHIEF MEDICAL OFFICER | Apr 15 | Apr 15 | S | 1,018 | $42.61 | Sale −$43,377 | 111,473 | Yes | Form 4 |
| Cline Christopher R.CHIEF FINANCIAL OFFICER | Apr 15 | Apr 15 | S | 1,014 | $42.61 | Sale −$43,207 | 116,899 | Yes | Form 4 |
| Reed Elizabeth EChief Legal Officer and GC | Apr 14 | Apr 15 | M | 10,000 | $19.08 | $190,800 | 129,211 | Yes | Form 4 |
| Reed Elizabeth EChief Legal Officer and GC | Apr 14 | Apr 15 | M | 20,000 | $17.96 | $359,200 | 149,211 | Yes | Form 4 |
| Reed Elizabeth EChief Legal Officer and GC | Apr 14 | Apr 15 | M | 7,500 | $15.46 | $115,950 | 156,711 | Yes | Form 4 |
| Reed Elizabeth EChief Legal Officer and GC | Apr 14 | Apr 15 | S | 37,500 | $41.07 | Sale −$1,540,125 | 119,211 | Yes | Form 4 |
| Reed Elizabeth EChief Legal Officer and GC | Apr 14 | Apr 15 | S | 7,215 | $41.93 | Sale −$302,525 | 111,996 | Yes | Form 4 |
| Reed Elizabeth EChief Legal Officer and GC | Apr 14 | Apr 15 | M · derivative | 7,500 | $15.46 | $115,950 | 37,500 | Yes | Form 4 |
| Reed Elizabeth EChief Legal Officer and GC | Apr 14 | Apr 15 | M · derivative | 10,000 | $19.08 | $190,800 | not reported | Yes | Form 4 |
| Reed Elizabeth EChief Legal Officer and GC | Apr 14 | Apr 15 | M · derivative | 20,000 | $17.96 | $359,200 | 20,000 | Yes | Form 4 |
| Heerma PeterCHIEF COMMERCIAL OFFICER | Apr 14 | Apr 15 | S | 7,215 | $41.93 | Sale −$302,525 | 138,608 | No | Form 4 |
| Inrig JulaCHIEF MEDICAL OFFICER | Apr 14 | Apr 15 | S | 7,215 | $41.93 | Sale −$302,525 | 112,491 | Yes | Form 4 |
| Cline Christopher R.CHIEF FINANCIAL OFFICER | Apr 14 | Apr 15 | S | 9 | $41.07 | Sale −$370 | 125,152 | Yes | Form 4 |
| Cline Christopher R.CHIEF FINANCIAL OFFICER | Apr 14 | Apr 15 | S | 7,239 | $41.93 | Sale −$303,531 | 117,913 | Yes | Form 4 |
| Reed Elizabeth EChief Legal Officer and GC | Apr 13 | Apr 15 | A | 14,000 | $0.00 | $0 | 119,211 | Yes | Form 4 |
| Rote William E.Chief Research Officer | Apr 13 | Apr 15 | A | 14,000 | $0.00 | $0 | 123,087 | Yes | Form 4 |
| Dube Eric MCHIEF EXECUTIVE OFFICER | Apr 13 | Apr 15 | A | 64,000 | $0.00 | $0 | 496,886 | Yes | Form 4 |
| Heerma PeterCHIEF COMMERCIAL OFFICER | Apr 13 | Apr 15 | A | 14,000 | $0.00 | $0 | 145,823 | No | Form 4 |
| Inrig JulaCHIEF MEDICAL OFFICER | Apr 13 | Apr 15 | A | 14,000 | $0.00 | $0 | 119,706 | Yes | Form 4 |
| Cline Christopher R.CHIEF FINANCIAL OFFICER | Apr 13 | Apr 15 | A | 14,000 | $0.00 | $0 | 125,226 | Yes | Form 4 |
| Cline Christopher R.CHIEF FINANCIAL OFFICER | Apr 13 | Apr 15 | S | 65 | $28.85 | Sale −$1,875 | 125,161 | Yes | Form 4 |
| Baynes Roy D. | Apr 6 | Apr 7 | M | 10,000 | $26.52 | $265,200 | 47,500 | Yes | Form 4 |
| Baynes Roy D. | Apr 6 | Apr 7 | S | 10,000 | $33.00 | Sale −$330,000 | 37,500 | Yes | Form 4 |
| Baynes Roy D. | Apr 6 | Apr 7 | M · derivative | 10,000 | $26.52 | $265,200 | not reported | Yes | Form 4 |
| Reed Elizabeth EChief Legal Officer and GC | Apr 1 | Apr 2 | M | 10,000 | $15.46 | $154,600 | 115,211 | Yes | Form 4 |
| Reed Elizabeth EChief Legal Officer and GC | Apr 1 | Apr 2 | S | 10,000 | $30.00 | Sale −$300,000 | 105,211 | Yes | Form 4 |
| Reed Elizabeth EChief Legal Officer and GC | Apr 1 | Apr 2 | M · derivative | 10,000 | $15.46 | $154,600 | 45,000 | Yes | Form 4 |
| Dube Eric MCHIEF EXECUTIVE OFFICER | Apr 1 | Apr 2 | M | 60,000 | $15.46 | $927,600 | 492,886 | Yes | Form 4 |
| Dube Eric MCHIEF EXECUTIVE OFFICER | Apr 1 | Apr 2 | S | 34,902 | $30.55 | Sale −$1,066,256 | 457,984 | Yes | Form 4 |
| Dube Eric MCHIEF EXECUTIVE OFFICER | Apr 1 | Apr 2 | S | 25,098 | $31.46 | Sale −$789,583 | 432,886 | Yes | Form 4 |
| Dube Eric MCHIEF EXECUTIVE OFFICER | Apr 1 | Apr 2 | M · derivative | 60,000 | $15.46 | $927,600 | not reported | Yes | Form 4 |
| Reed Elizabeth EChief Legal Officer and GC | Mar 16 | Mar 18 | M | 10,000 | $19.08 | $190,800 | 115,211 | Yes | Form 4 |
| Reed Elizabeth EChief Legal Officer and GC | Mar 16 | Mar 18 | S | 10,000 | $28.09 | Sale −$280,900 | 105,211 | Yes | Form 4 |
| Reed Elizabeth EChief Legal Officer and GC | Mar 16 | Mar 18 | M · derivative | 10,000 | $19.08 | $190,800 | 10,000 | Yes | Form 4 |
| Dube Eric MCHIEF EXECUTIVE OFFICER | Feb 20 | Feb 24 | M | 60,000 | $15.46 | $927,600 | 492,886 | Yes | Form 4 |
| Dube Eric MCHIEF EXECUTIVE OFFICER | Feb 20 | Feb 24 | S | 60,000 | $30.10 | Sale −$1,806,000 | 432,886 | Yes | Form 4 |
| Dube Eric MCHIEF EXECUTIVE OFFICER | Feb 20 | Feb 24 | M · derivative | 60,000 | $15.46 | $927,600 | 60,000 | Yes | Form 4 |
| Reed Elizabeth EChief Legal Officer and GC | Feb 17 | Feb 19 | M | 10,000 | $19.08 | $190,800 | 115,211 | Yes | Form 4 |
| Reed Elizabeth EChief Legal Officer and GC | Feb 17 | Feb 19 | S | 5,679 | $27.50 | Sale −$156,173 | 109,532 | Yes | Form 4 |
| Reed Elizabeth EChief Legal Officer and GC | Feb 17 | Feb 19 | S | 4,321 | $28.26 | Sale −$122,111 | 105,211 | Yes | Form 4 |
| Reed Elizabeth EChief Legal Officer and GC | Feb 17 | Feb 19 | M · derivative | 10,000 | $19.08 | $190,800 | 20,000 | Yes | Form 4 |
| Reed Elizabeth EChief Legal Officer and GC | Feb 4 | Feb 5 | S | 2,485 | $32.07 | Sale −$79,694 | 105,720 | Yes | Form 4 |
| Reed Elizabeth EChief Legal Officer and GC | Feb 4 | Feb 5 | S | 509 | $32.74 | Sale −$16,665 | 105,211 | Yes | Form 4 |
| Inrig JulaCHIEF MEDICAL OFFICER | Feb 4 | Feb 5 | S | 1,547 | $32.11 | Sale −$49,674 | 105,938 | Yes | Form 4 |
| Inrig JulaCHIEF MEDICAL OFFICER | Feb 4 | Feb 5 | S | 232 | $32.85 | Sale −$7,621 | 105,706 | Yes | Form 4 |
| Cline Christopher R.CHIEF FINANCIAL OFFICER | Feb 4 | Feb 5 | S | 1,635 | $32.14 | Sale −$52,549 | 111,336 | Yes | Form 4 |
| Cline Christopher R.CHIEF FINANCIAL OFFICER | Feb 4 | Feb 5 | S | 110 | $32.90 | Sale −$3,619 | 111,226 | Yes | Form 4 |
| Reed Elizabeth EChief Legal Officer and GC | Feb 3 | Feb 3 | S | 7,175 | $32.12 | Sale −$230,461 | 108,205 | No | Form 4 |
| Rote William E.Chief Research Officer | Feb 3 | Feb 3 | S | 12,446 | $32.87 | Sale −$409,100 | 109,087 | Yes | Form 4 |
| Dube Eric MCHIEF EXECUTIVE OFFICER | Feb 3 | Feb 3 | S | 66,452 | $32.06 | Sale −$2,130,451 | 466,521 | Yes | Form 4 |
| Dube Eric MCHIEF EXECUTIVE OFFICER | Feb 3 | Feb 3 | S | 33,635 | $32.70 | Sale −$1,099,865 | 432,886 | Yes | Form 4 |
| Heerma PeterCHIEF COMMERCIAL OFFICER | Feb 3 | Feb 3 | S | 7,310 | $32.12 | Sale −$234,797 | 131,823 | No | Form 4 |
| Calvin SandraSVP, CHIEF ACCOUNTING OFFICER | Feb 3 | Feb 3 | S | 4,333 | $32.12 | Sale −$139,176 | 49,080 | No | Form 4 |
| Inrig JulaCHIEF MEDICAL OFFICER | Feb 3 | Feb 3 | S | 6,956 | $32.12 | Sale −$223,427 | 107,485 | No | Form 4 |
| Cline Christopher R.CHIEF FINANCIAL OFFICER | Feb 3 | Feb 3 | S | 7,242 | $32.12 | Sale −$232,613 | 112,971 | No | Form 4 |
| Reed Elizabeth EChief Legal Officer and GC | Jan 31 | Feb 3 | A | 25,110 | $0.00 | $0 | 115,380 | No | Form 4 |
| Reed Elizabeth EChief Legal Officer and GC | Jan 31 | Feb 3 | A · derivative | 66,960 | $33.10 | $2,216,376 | 66,960 | No | Form 4 |
| Rote William E.Chief Research Officer | Jan 31 | Feb 3 | A | 20,090 | $0.00 | $0 | 121,533 | Yes | Form 4 |
| Rote William E.Chief Research Officer | Jan 31 | Feb 3 | A · derivative | 53,570 | $33.10 | $1,773,167 | 53,570 | Yes | Form 4 |
| Dube Eric MCHIEF EXECUTIVE OFFICER | Jan 31 | Feb 3 | A | 113,800 | $0.00 | $0 | 532,973 | Yes | Form 4 |
| Dube Eric MCHIEF EXECUTIVE OFFICER | Jan 31 | Feb 3 | A · derivative | 303,600 | $33.10 | $10,049,160 | 303,600 | Yes | Form 4 |
| Heerma PeterCHIEF COMMERCIAL OFFICER | Jan 31 | Feb 3 | A | 26,120 | $0.00 | $0 | 139,133 | No | Form 4 |
| Heerma PeterCHIEF COMMERCIAL OFFICER | Jan 31 | Feb 3 | A · derivative | 69,640 | $33.10 | $2,305,084 | 69,640 | No | Form 4 |
| Calvin SandraSVP, CHIEF ACCOUNTING OFFICER | Jan 31 | Feb 3 | A | 15,180 | $0.00 | $0 | 53,413 | No | Form 4 |
| Calvin SandraSVP, CHIEF ACCOUNTING OFFICER | Jan 31 | Feb 3 | A · derivative | 20,160 | $33.10 | $667,296 | 20,160 | No | Form 4 |
| Inrig JulaCHIEF MEDICAL OFFICER | Jan 31 | Feb 3 | A | 28,130 | $0.00 | $0 | 114,441 | No | Form 4 |
| Inrig JulaCHIEF MEDICAL OFFICER | Jan 31 | Feb 3 | A · derivative | 75,000 | $33.10 | $2,482,500 | 75,000 | No | Form 4 |
| Cline Christopher R.CHIEF FINANCIAL OFFICER | Jan 31 | Feb 3 | A | 28,130 | $0.00 | $0 | 120,213 | No | Form 4 |
| Cline Christopher R.CHIEF FINANCIAL OFFICER | Jan 31 | Feb 3 | A · derivative | 75,000 | $33.10 | $2,482,500 | 75,000 | No | Form 4 |
| Dube Eric MCHIEF EXECUTIVE OFFICER | Jan 27 | Jan 27 | M | 51,865 | $15.46 | $801,833 | 471,038 | Yes | Form 4 |
| Dube Eric MCHIEF EXECUTIVE OFFICER | Jan 27 | Jan 27 | S | 51,865 | $30.10 | Sale −$1,561,137 | 419,173 | Yes | Form 4 |
| Dube Eric MCHIEF EXECUTIVE OFFICER | Jan 27 | Jan 27 | M · derivative | 51,865 | $15.46 | $801,833 | 120,000 | Yes | Form 4 |
| Dube Eric MCHIEF EXECUTIVE OFFICER | Jan 23 | Jan 27 | M | 8,135 | $15.46 | $125,767 | 427,308 | Yes | Form 4 |
| Dube Eric MCHIEF EXECUTIVE OFFICER | Jan 23 | Jan 27 | S | 8,135 | $30.01 | Sale −$244,131 | 419,173 | Yes | Form 4 |
| Dube Eric MCHIEF EXECUTIVE OFFICER | Jan 23 | Jan 27 | M · derivative | 8,135 | $15.46 | $125,767 | 171,865 | Yes | Form 4 |
| Reed Elizabeth EChief Legal Officer and GC | Jan 20 | Jan 21 | M | 10,000 | $19.08 | $190,800 | 100,270 | Yes | Form 4 |
| Reed Elizabeth EChief Legal Officer and GC | Jan 20 | Jan 21 | S | 10,000 | $27.34 | Sale −$273,400 | 90,270 | Yes | Form 4 |
| Reed Elizabeth EChief Legal Officer and GC | Jan 20 | Jan 21 | M · derivative | 10,000 | $19.08 | $190,800 | 30,000 | Yes | Form 4 |
| Inrig JulaCHIEF MEDICAL OFFICER | Jan 6 | Jan 7 | S | 445 | $37.75 | Sale −$16,799 | 86,311 | Yes | Form 4 |
| Inrig JulaCHIEF MEDICAL OFFICER | Jan 5 | Jan 7 | S | 2,031 | $40.18 | Sale −$81,606 | 86,756 | Yes | Form 4 |
| Rote William E.Chief Research Officer | Dec 24, 2025 | Dec 29, 2025 | M | 60,000 | $20.61 | $1,236,600 | 161,443 | Yes | Form 4 |
| Rote William E.Chief Research Officer | Dec 24, 2025 | Dec 29, 2025 | S | 60,000 | $40.10 | Sale −$2,406,000 | 101,443 | Yes | Form 4 |
| Rote William E.Chief Research Officer | Dec 24, 2025 | Dec 29, 2025 | M · derivative | 60,000 | $20.61 | $1,236,600 | not reported | Yes | Form 4 |
| Heerma PeterCHIEF COMMERCIAL OFFICER | Dec 24, 2025 | Dec 29, 2025 | S | 4,980 | $40.00 | Sale −$199,200 | 113,013 | Yes | Form 4 |
| Calvin SandraSVP, CHIEF ACCOUNTING OFFICER | Dec 24, 2025 | Dec 29, 2025 | S | 7,402 | $40.00 | Sale −$296,080 | 38,233 | Yes | Form 4 |
| Inrig JulaCHIEF MEDICAL OFFICER | Dec 24, 2025 | Dec 29, 2025 | M | 15,000 | $8.93 | $133,950 | 103,787 | Yes | Form 4 |
| Inrig JulaCHIEF MEDICAL OFFICER | Dec 24, 2025 | Dec 29, 2025 | S | 15,000 | $42.00 | Sale −$630,000 | 88,787 | Yes | Form 4 |
| Inrig JulaCHIEF MEDICAL OFFICER | Dec 24, 2025 | Dec 29, 2025 | M · derivative | 15,000 | $8.93 | $133,950 | 76,000 | Yes | Form 4 |
| Calvin SandraSVP, CHIEF ACCOUNTING OFFICER | Dec 15, 2025 | Dec 16, 2025 | S | 2,910 | $36.00 | Sale −$104,760 | 45,635 | Yes | Form 4 |
| Cline Christopher R.CHIEF FINANCIAL OFFICER | Dec 1, 2025 | Dec 3, 2025 | M | 20,000 | $16.23 | $324,600 | 112,083 | Yes | Form 4 |
| Cline Christopher R.CHIEF FINANCIAL OFFICER | Dec 1, 2025 | Dec 3, 2025 | S | 20,000 | $35.01 | Sale −$700,200 | 92,083 | Yes | Form 4 |
| Cline Christopher R.CHIEF FINANCIAL OFFICER | Dec 1, 2025 | Dec 3, 2025 | M · derivative | 20,000 | $16.23 | $324,600 | not reported | Yes | Form 4 |
| Calvin SandraSVP, CHIEF ACCOUNTING OFFICER | Nov 4, 2025 | Nov 6, 2025 | M | 10,000 | $25.25 | $252,500 | 64,410 | Yes | Form 4 |
| Calvin SandraSVP, CHIEF ACCOUNTING OFFICER | Nov 4, 2025 | Nov 6, 2025 | M | 17,500 | $26.88 | $470,400 | 81,910 | Yes | Form 4 |
| Calvin SandraSVP, CHIEF ACCOUNTING OFFICER | Nov 4, 2025 | Nov 6, 2025 | M | 15,000 | $27.50 | $412,500 | 96,910 | Yes | Form 4 |
| Calvin SandraSVP, CHIEF ACCOUNTING OFFICER | Nov 4, 2025 | Nov 6, 2025 | M | 12,500 | $22.40 | $280,000 | 109,410 | Yes | Form 4 |
| Calvin SandraSVP, CHIEF ACCOUNTING OFFICER | Nov 4, 2025 | Nov 6, 2025 | M | 6,250 | $8.93 | $55,813 | 115,660 | Yes | Form 4 |
| Calvin SandraSVP, CHIEF ACCOUNTING OFFICER | Nov 4, 2025 | Nov 6, 2025 | S | 67,115 | $36.00 | Sale −$2,416,140 | 48,545 | Yes | Form 4 |
| Calvin SandraSVP, CHIEF ACCOUNTING OFFICER | Nov 4, 2025 | Nov 6, 2025 | M · derivative | 10,000 | $25.25 | $252,500 | not reported | Yes | Form 4 |
| Calvin SandraSVP, CHIEF ACCOUNTING OFFICER | Nov 4, 2025 | Nov 6, 2025 | M · derivative | 17,500 | $26.88 | $470,400 | not reported | Yes | Form 4 |
| Calvin SandraSVP, CHIEF ACCOUNTING OFFICER | Nov 4, 2025 | Nov 6, 2025 | M · derivative | 15,000 | $27.50 | $412,500 | 2,500 | Yes | Form 4 |
| Calvin SandraSVP, CHIEF ACCOUNTING OFFICER | Nov 4, 2025 | Nov 6, 2025 | M · derivative | 12,500 | $22.40 | $280,000 | 7,500 | Yes | Form 4 |
| Calvin SandraSVP, CHIEF ACCOUNTING OFFICER | Nov 4, 2025 | Nov 6, 2025 | M · derivative | 6,250 | $8.93 | $55,813 | 18,750 | Yes | Form 4 |
| Heerma PeterCHIEF COMMERCIAL OFFICER | Nov 3, 2025 | Nov 4, 2025 | G | 1,078 | $0.00 | $0 | 117,993 | Yes | Form 4 |
| Coughlin Timothy | Oct 31, 2025 | Nov 4, 2025 | M | 8,000 | $16.33 | $130,640 | 63,500 | Yes | Form 4 |
| Coughlin Timothy | Oct 31, 2025 | Nov 4, 2025 | M | 10,000 | $17.44 | $174,400 | 73,500 | Yes | Form 4 |
| Coughlin Timothy | Oct 31, 2025 | Nov 4, 2025 | S | 18,000 | $35.03 | Sale −$630,540 | 55,500 | Yes | Form 4 |
| Coughlin Timothy | Oct 31, 2025 | Nov 4, 2025 | M · derivative | 8,000 | $16.33 | $130,640 | not reported | Yes | Form 4 |
| Coughlin Timothy | Oct 31, 2025 | Nov 4, 2025 | M · derivative | 10,000 | $17.44 | $174,400 | not reported | Yes | Form 4 |
| Heerma PeterCHIEF COMMERCIAL OFFICER | Oct 31, 2025 | Nov 4, 2025 | S | 5,591 | $35.00 | Sale −$195,685 | 119,071 | Yes | Form 4 |
| Dube Eric MCHIEF EXECUTIVE OFFICER | Oct 29, 2025 | Oct 30, 2025 | M | 27,128 | $15.46 | $419,399 | 446,301 | Yes | Form 4 |
| Dube Eric MCHIEF EXECUTIVE OFFICER | Oct 29, 2025 | Oct 30, 2025 | S | 27,128 | $30.12 | Sale −$817,095 | 419,173 | Yes | Form 4 |
| Dube Eric MCHIEF EXECUTIVE OFFICER | Oct 29, 2025 | Oct 30, 2025 | M · derivative | 27,128 | $15.46 | $419,399 | 180,000 | Yes | Form 4 |
| Dube Eric MCHIEF EXECUTIVE OFFICER | Oct 28, 2025 | Oct 30, 2025 | M | 92,872 | $15.46 | $1,435,801 | 512,045 | Yes | Form 4 |
| Dube Eric MCHIEF EXECUTIVE OFFICER | Oct 28, 2025 | Oct 30, 2025 | S | 92,872 | $30.38 | Sale −$2,821,451 | 419,173 | Yes | Form 4 |
| Dube Eric MCHIEF EXECUTIVE OFFICER | Oct 28, 2025 | Oct 30, 2025 | M · derivative | 92,872 | $15.46 | $1,435,801 | 207,128 | Yes | Form 4 |
| Heerma PeterCHIEF COMMERCIAL OFFICER | Oct 28, 2025 | Oct 30, 2025 | S | 2,662 | $30.00 | Sale −$79,860 | 124,662 | Yes | Form 4 |
| Heerma PeterCHIEF COMMERCIAL OFFICER | Sep 23, 2025 | Sep 24, 2025 | G | 891 | $0.00 | $0 | 127,324 | Yes | Form 4 |
| Reed Elizabeth EChief Legal Officer and GC | Sep 22, 2025 | Sep 24, 2025 | M | 10,000 | $19.08 | $190,800 | 99,878 | Yes | Form 4 |
| Reed Elizabeth EChief Legal Officer and GC | Sep 22, 2025 | Sep 24, 2025 | S | 10,000 | $25.00 | Sale −$250,000 | 89,878 | Yes | Form 4 |
| Reed Elizabeth EChief Legal Officer and GC | Sep 22, 2025 | Sep 24, 2025 | M · derivative | 10,000 | $19.08 | $190,800 | 40,000 | Yes | Form 4 |
| Cline Christopher R.CHIEF FINANCIAL OFFICER | Sep 4, 2025 | Sep 5, 2025 | S | 119 | $19.71 | Sale −$2,345 | 92,083 | Yes | Form 4 |
| Cline Christopher R.CHIEF FINANCIAL OFFICER | Sep 3, 2025 | Sep 5, 2025 | S | 454 | $18.20 | Sale −$8,263 | 92,202 | Yes | Form 4 |
| Cline Christopher R.CHIEF FINANCIAL OFFICER | Aug 27, 2025 | Aug 28, 2025 | S | 470 | $17.31 | Sale −$8,136 | 92,656 | Yes | Form 4 |
| Inrig JulaCHIEF MEDICAL OFFICER | Jul 1, 2025 | Jul 2, 2025 | S | 815 | $14.65 | Sale −$11,940 | 88,787 | Yes | Form 4 |
| Baynes Roy D. | May 15, 2025 | May 16, 2025 | A | 6,500 | $0.00 | $0 | 37,500 | No | Form 4 |
| Baynes Roy D. | May 15, 2025 | May 16, 2025 | A · derivative | 19,500 | $21.15 | $412,425 | 19,500 | No | Form 4 |
| Bruhn Suzanne Louise | May 15, 2025 | May 16, 2025 | A | 6,500 | $0.00 | $0 | 28,750 | No | Form 4 |
| Bruhn Suzanne Louise | May 15, 2025 | May 16, 2025 | A · derivative | 19,500 | $21.15 | $412,425 | 19,500 | No | Form 4 |
| Coughlin Timothy | May 15, 2025 | May 16, 2025 | A | 6,500 | $0.00 | $0 | 55,500 | No | Form 4 |
| Coughlin Timothy | May 15, 2025 | May 16, 2025 | A · derivative | 19,500 | $21.15 | $412,425 | 19,500 | No | Form 4 |
| Lyons Gary A | May 15, 2025 | May 16, 2025 | A | 6,500 | $0.00 | $0 | 57,500 | No | Form 4 |
| Lyons Gary A | May 15, 2025 | May 16, 2025 | A · derivative | 19,500 | $21.15 | $412,425 | 19,500 | No | Form 4 |
| Meckler Jeffrey A | May 15, 2025 | May 16, 2025 | A | 6,500 | $0.00 | $0 | 87,500 | No | Form 4 |
| Meckler Jeffrey A | May 15, 2025 | May 16, 2025 | A · derivative | 19,500 | $21.15 | $412,425 | 19,500 | No | Form 4 |
| Orwin John A | May 15, 2025 | May 16, 2025 | A | 6,500 | $0.00 | $0 | 35,375 | No | Form 4 |
| Orwin John A | May 15, 2025 | May 16, 2025 | A · derivative | 19,500 | $21.15 | $412,425 | 19,500 | No | Form 4 |
| Poole Sandra | May 15, 2025 | May 16, 2025 | A | 6,500 | $0.00 | $0 | 30,000 | No | Form 4 |
| Poole Sandra | May 15, 2025 | May 16, 2025 | A · derivative | 19,500 | $21.15 | $412,425 | 19,500 | No | Form 4 |
| Squarer Ron | May 15, 2025 | May 16, 2025 | A | 6,500 | $0.00 | $0 | 35,375 | No | Form 4 |
| Squarer Ron | May 15, 2025 | May 16, 2025 | A · derivative | 19,500 | $21.15 | $412,425 | 19,500 | No | Form 4 |
| Williams Brinkley Ruth | May 15, 2025 | May 16, 2025 | A | 6,500 | $0.00 | $0 | 25,750 | No | Form 4 |
| Williams Brinkley Ruth | May 15, 2025 | May 16, 2025 | A · derivative | 19,500 | $21.15 | $412,425 | 19,500 | No | Form 4 |
| Reed Elizabeth EChief Legal Officer and GC | May 5, 2025 | May 5, 2025 | S | 4,920 | $21.05 | Sale −$103,566 | 89,482 | Yes | Form 4 |
| Rote William E.Chief Research Officer | May 5, 2025 | May 5, 2025 | S | 3,198 | $21.05 | Sale −$67,318 | 100,241 | Yes | Form 4 |
| Heerma PeterCHIEF COMMERCIAL OFFICER | May 5, 2025 | May 5, 2025 | S | 1,771 | $21.05 | Sale −$37,280 | 128,215 | No | Form 4 |
| Dube Eric MCHIEF EXECUTIVE OFFICER | May 5, 2025 | May 5, 2025 | S | 18,924 | $21.05 | Sale −$398,350 | 419,173 | Yes | Form 4 |
| Cline Christopher R.CHIEF FINANCIAL OFFICER | May 5, 2025 | May 5, 2025 | S | 1,784 | $21.05 | Sale −$37,553 | 93,126 | No | Form 4 |
| Reed Elizabeth EChief Legal Officer and GC | May 2, 2025 | May 5, 2025 | M | 4,920 | not reported | not reported | 94,402 | Yes | Form 4 |
| Reed Elizabeth EChief Legal Officer and GC | May 2, 2025 | May 5, 2025 | M · derivative | 4,920 | $0.00 | $0 | 4,920 | Yes | Form 4 |
| Rote William E.Chief Research Officer | May 2, 2025 | May 5, 2025 | M | 4,920 | not reported | not reported | 103,439 | Yes | Form 4 |
| Rote William E.Chief Research Officer | May 2, 2025 | May 5, 2025 | M · derivative | 4,920 | $0.00 | $0 | 4,920 | Yes | Form 4 |
| Heerma PeterCHIEF COMMERCIAL OFFICER | May 2, 2025 | May 5, 2025 | M | 4,920 | not reported | not reported | 129,986 | No | Form 4 |
| Heerma PeterCHIEF COMMERCIAL OFFICER | May 2, 2025 | May 5, 2025 | M · derivative | 4,920 | $0.00 | $0 | 4,920 | No | Form 4 |
| Dube Eric MCHIEF EXECUTIVE OFFICER | May 2, 2025 | May 5, 2025 | M | 18,924 | not reported | not reported | 438,097 | Yes | Form 4 |
| Dube Eric MCHIEF EXECUTIVE OFFICER | May 2, 2025 | May 5, 2025 | M · derivative | 18,924 | $0.00 | $0 | 18,924 | Yes | Form 4 |
| Cline Christopher R.CHIEF FINANCIAL OFFICER | May 2, 2025 | May 5, 2025 | M | 4,920 | not reported | not reported | 94,910 | No | Form 4 |
| Cline Christopher R.CHIEF FINANCIAL OFFICER | May 2, 2025 | May 5, 2025 | M · derivative | 4,920 | $0.00 | $0 | 4,920 | No | Form 4 |
| Cline Christopher R.CHIEF FINANCIAL OFFICER | Apr 11, 2025 | Apr 14, 2025 | S | 48 | $13.14 | Sale −$631 | 89,990 | No | Form 4 |
| Inrig JulaCHIEF MEDICAL OFFICER | Feb 12, 2025 | Feb 12, 2025 | S | 2,568 | $23.53 | Sale −$60,425 | 89,602 | No | Form 4 |
| Heerma PeterCHIEF COMMERCIAL OFFICER | Feb 12, 2025 | Feb 12, 2025 | S | 2,568 | $23.53 | Sale −$60,425 | 125,066 | Yes | Form 4 |
| Reed Elizabeth ESVP, GC & CORPORATE SECRETARY | Feb 12, 2025 | Feb 12, 2025 | S | 8,000 | $23.53 | Sale −$188,240 | 89,482 | Yes | Form 4 |
| Rote William E.SENIOR VICE PRESIDENT, R&D | Feb 12, 2025 | Feb 12, 2025 | S | 5,200 | $23.53 | Sale −$122,356 | 98,519 | Yes | Form 4 |
| Dube Eric MCHIEF EXECUTIVE OFFICER | Feb 11, 2025 | Feb 12, 2025 | S | 11,375 | $24.04 | Sale −$273,455 | 419,173 | Yes | Form 4 |
| Heerma PeterCHIEF COMMERCIAL OFFICER | Feb 11, 2025 | Feb 12, 2025 | S | 3,074 | $25.00 | Sale −$76,850 | 127,634 | Yes | Form 4 |
| Calvin SandraSVP, CHIEF ACCOUNTING OFFICER | Feb 11, 2025 | Feb 12, 2025 | M | 10,000 | $16.23 | $162,300 | 73,654 | Yes | Form 4 |
| Calvin SandraSVP, CHIEF ACCOUNTING OFFICER | Feb 11, 2025 | Feb 12, 2025 | S | 10,000 | $25.00 | Sale −$250,000 | 63,654 | Yes | Form 4 |
| Calvin SandraSVP, CHIEF ACCOUNTING OFFICER | Feb 11, 2025 | Feb 12, 2025 | M | 10,000 | $17.44 | $174,400 | 73,654 | Yes | Form 4 |
| Calvin SandraSVP, CHIEF ACCOUNTING OFFICER | Feb 11, 2025 | Feb 12, 2025 | S | 10,000 | $25.00 | Sale −$250,000 | 63,654 | Yes | Form 4 |
| Calvin SandraSVP, CHIEF ACCOUNTING OFFICER | Feb 11, 2025 | Feb 12, 2025 | M | 10,000 | $17.96 | $179,600 | 73,654 | Yes | Form 4 |
| Calvin SandraSVP, CHIEF ACCOUNTING OFFICER | Feb 11, 2025 | Feb 12, 2025 | S | 10,000 | $25.00 | Sale −$250,000 | 63,654 | Yes | Form 4 |
| Calvin SandraSVP, CHIEF ACCOUNTING OFFICER | Feb 11, 2025 | Feb 12, 2025 | M | 15,000 | $15.46 | $231,900 | 78,654 | Yes | Form 4 |
| Calvin SandraSVP, CHIEF ACCOUNTING OFFICER | Feb 11, 2025 | Feb 12, 2025 | S | 15,000 | $25.00 | Sale −$375,000 | 63,654 | Yes | Form 4 |
| Calvin SandraSVP, CHIEF ACCOUNTING OFFICER | Feb 11, 2025 | Feb 12, 2025 | S | 9,244 | $25.00 | Sale −$231,100 | 54,410 | Yes | Form 4 |
| Calvin SandraSVP, CHIEF ACCOUNTING OFFICER | Feb 11, 2025 | Feb 12, 2025 | M · derivative | 10,000 | $16.23 | $162,300 | not reported | Yes | Form 4 |
| Calvin SandraSVP, CHIEF ACCOUNTING OFFICER | Feb 11, 2025 | Feb 12, 2025 | M · derivative | 10,000 | $17.44 | $174,400 | not reported | Yes | Form 4 |
| Calvin SandraSVP, CHIEF ACCOUNTING OFFICER | Feb 11, 2025 | Feb 12, 2025 | M · derivative | 10,000 | $17.96 | $179,600 | not reported | Yes | Form 4 |
| Calvin SandraSVP, CHIEF ACCOUNTING OFFICER | Feb 11, 2025 | Feb 12, 2025 | M · derivative | 15,000 | $15.46 | $231,900 | not reported | Yes | Form 4 |
| Inrig JulaCHIEF MEDICAL OFFICER | Feb 10, 2025 | Feb 12, 2025 | M | 8,000 | not reported | not reported | 92,170 | No | Form 4 |
| Inrig JulaCHIEF MEDICAL OFFICER | Feb 10, 2025 | Feb 12, 2025 | M · derivative | 8,000 | $0.00 | $0 | not reported | No | Form 4 |
| Heerma PeterCHIEF COMMERCIAL OFFICER | Feb 10, 2025 | Feb 12, 2025 | M | 8,000 | not reported | not reported | 130,708 | Yes | Form 4 |
| Heerma PeterCHIEF COMMERCIAL OFFICER | Feb 10, 2025 | Feb 12, 2025 | M · derivative | 8,000 | $0.00 | $0 | not reported | Yes | Form 4 |
| Reed Elizabeth ESVP, GC & CORPORATE SECRETARY | Feb 10, 2025 | Feb 12, 2025 | M | 8,000 | not reported | not reported | 97,482 | Yes | Form 4 |
| Reed Elizabeth ESVP, GC & CORPORATE SECRETARY | Feb 10, 2025 | Feb 12, 2025 | M · derivative | 8,000 | $0.00 | $0 | not reported | Yes | Form 4 |
| Rote William E.SENIOR VICE PRESIDENT, R&D | Feb 10, 2025 | Feb 12, 2025 | M | 8,000 | not reported | not reported | 103,719 | Yes | Form 4 |
| Rote William E.SENIOR VICE PRESIDENT, R&D | Feb 10, 2025 | Feb 12, 2025 | M · derivative | 8,000 | $0.00 | $0 | not reported | Yes | Form 4 |
| Baynes Roy D. | Feb 6, 2025 | Feb 10, 2025 | M | 10,000 | $17.44 | $174,400 | 41,000 | Yes | Form 4 |
| Baynes Roy D. | Feb 6, 2025 | Feb 10, 2025 | S | 10,000 | $22.00 | Sale −$220,000 | 31,000 | Yes | Form 4 |
| Baynes Roy D. | Feb 6, 2025 | Feb 10, 2025 | M · derivative | 10,000 | $17.44 | $174,400 | not reported | Yes | Form 4 |
| Inrig JulaCHIEF MEDICAL OFFICER | Feb 4, 2025 | Feb 4, 2025 | S | 1,066 | $20.11 | Sale −$21,437 | 84,170 | Yes | Form 4 |
| Calvin SandraSVP, CHIEF ACCOUNTING OFFICER | Feb 3, 2025 | Feb 4, 2025 | S | 3,348 | $20.12 | Sale −$67,362 | 63,654 | No | Form 4 |
| Cline Christopher R.CHIEF FINANCIAL OFFICER | Feb 3, 2025 | Feb 4, 2025 | S | 5,192 | $20.12 | Sale −$104,463 | 90,038 | No | Form 4 |
| Heerma PeterCHIEF COMMERCIAL OFFICER | Feb 3, 2025 | Feb 4, 2025 | S | 5,166 | $20.12 | Sale −$103,940 | 122,708 | No | Form 4 |
| Inrig JulaCHIEF MEDICAL OFFICER | Feb 3, 2025 | Feb 4, 2025 | S | 4,207 | $20.12 | Sale −$84,645 | 85,236 | Yes | Form 4 |
| Dube Eric MCHIEF EXECUTIVE OFFICER | Feb 3, 2025 | Feb 4, 2025 | S | 50,691 | $20.21 | Sale −$1,024,465 | 430,548 | Yes | Form 4 |
| Reed Elizabeth ESVP, GC & CORPORATE SECRETARY | Feb 3, 2025 | Feb 4, 2025 | S | 8,951 | $19.78 | Sale −$177,051 | 89,482 | Yes | Form 4 |
| Rote William E.SENIOR VICE PRESIDENT, R&D | Feb 3, 2025 | Feb 4, 2025 | S | 8,951 | $19.78 | Sale −$177,051 | 95,719 | Yes | Form 4 |
| Calvin SandraSVP, CHIEF ACCOUNTING OFFICER | Jan 31, 2025 | Feb 4, 2025 | A | 13,000 | $0.00 | $0 | 67,002 | No | Form 4 |
| Calvin SandraSVP, CHIEF ACCOUNTING OFFICER | Jan 31, 2025 | Feb 4, 2025 | A · derivative | 26,000 | $20.46 | $531,960 | 26,000 | No | Form 4 |
| Cline Christopher R.CHIEF FINANCIAL OFFICER | Jan 31, 2025 | Feb 4, 2025 | A | 21,500 | $0.00 | $0 | 95,230 | No | Form 4 |
| Cline Christopher R.CHIEF FINANCIAL OFFICER | Jan 31, 2025 | Feb 4, 2025 | A · derivative | 58,000 | $20.46 | $1,186,680 | 58,000 | No | Form 4 |
| Heerma PeterCHIEF COMMERCIAL OFFICER | Jan 31, 2025 | Feb 4, 2025 | A | 21,500 | $0.00 | $0 | 127,874 | No | Form 4 |
| Heerma PeterCHIEF COMMERCIAL OFFICER | Jan 31, 2025 | Feb 4, 2025 | A · derivative | 58,000 | $20.46 | $1,186,680 | 58,000 | No | Form 4 |
| Inrig JulaCHIEF MEDICAL OFFICER | Jan 31, 2025 | Feb 4, 2025 | A | 30,000 | $0.00 | $0 | 89,443 | Yes | Form 4 |
| Inrig JulaCHIEF MEDICAL OFFICER | Jan 31, 2025 | Feb 4, 2025 | A · derivative | 100,000 | $20.46 | $2,046,000 | 100,000 | Yes | Form 4 |
| Dube Eric MCHIEF EXECUTIVE OFFICER | Jan 31, 2025 | Feb 4, 2025 | A | 130,000 | $0.00 | $0 | 481,239 | Yes | Form 4 |
| Dube Eric MCHIEF EXECUTIVE OFFICER | Jan 31, 2025 | Feb 4, 2025 | A · derivative | 260,000 | $20.46 | $5,319,600 | 260,000 | Yes | Form 4 |
| Reed Elizabeth ESVP, GC & CORPORATE SECRETARY | Jan 31, 2025 | Feb 4, 2025 | A | 21,500 | $0.00 | $0 | 98,433 | Yes | Form 4 |
| Reed Elizabeth ESVP, GC & CORPORATE SECRETARY | Jan 31, 2025 | Feb 4, 2025 | A · derivative | 58,000 | $20.46 | $1,186,680 | 58,000 | Yes | Form 4 |
| Rote William E.SENIOR VICE PRESIDENT, R&D | Jan 31, 2025 | Feb 4, 2025 | A | 21,500 | $0.00 | $0 | 104,670 | Yes | Form 4 |
| Rote William E.SENIOR VICE PRESIDENT, R&D | Jan 31, 2025 | Feb 4, 2025 | A · derivative | 58,000 | $20.46 | $1,186,680 | 58,000 | Yes | Form 4 |
| Baynes Roy D. | Jan 23, 2025 | Jan 23, 2025 | M | 16,000 | $17.50 | $280,000 | 47,000 | Yes | Form 4 |
| Baynes Roy D. | Jan 23, 2025 | Jan 23, 2025 | S | 16,000 | $20.00 | Sale −$320,000 | 31,000 | Yes | Form 4 |
| Baynes Roy D. | Jan 23, 2025 | Jan 23, 2025 | M · derivative | 16,000 | $17.50 | $280,000 | not reported | Yes | Form 4 |
| Calvin SandraSVP, CHIEF ACCOUNTING OFFICER | Jan 22, 2025 | Jan 23, 2025 | S | 925 | $18.94 | Sale −$17,520 | 54,002 | No | Form 4 |
| Cline Christopher R.CHIEF FINANCIAL OFFICER | Jan 22, 2025 | Jan 23, 2025 | S | 865 | $18.94 | Sale −$16,383 | 73,730 | No | Form 4 |
| Heerma PeterCHIEF COMMERCIAL OFFICER | Jan 22, 2025 | Jan 23, 2025 | S | 1,584 | $18.94 | Sale −$30,001 | 106,374 | No | Form 4 |
| Reed Elizabeth ESVP, GC & CORPORATE SECRETARY | Jan 22, 2025 | Jan 23, 2025 | S | 2,437 | $19.46 | Sale −$47,424 | 76,933 | Yes | Form 4 |
| Dube Eric MCHIEF EXECUTIVE OFFICER | Jan 22, 2025 | Jan 23, 2025 | S | 10,736 | $19.46 | Sale −$208,923 | 351,239 | Yes | Form 4 |
| Rote William E.SENIOR VICE PRESIDENT, R&D | Jan 22, 2025 | Jan 23, 2025 | S | 2,437 | $19.46 | Sale −$47,424 | 83,170 | Yes | Form 4 |
| Inrig JulaCHIEF MEDICAL OFFICER | Jan 6, 2025 | Jan 6, 2025 | S | 440 | $18.76 | Sale −$8,254 | 59,443 | Yes | Form 4 |
| Inrig JulaCHIEF MEDICAL OFFICER | Jan 3, 2025 | Jan 6, 2025 | S | 2,066 | $19.10 | Sale −$39,461 | 59,883 | Yes | Form 4 |
| Calvin SandraSVP, CHIEF ACCOUNTING OFFICER | Dec 26, 2024 | Dec 27, 2024 | M | 15,000 | $12.67 | $190,050 | 69,927 | Yes | Form 4 |
| Calvin SandraSVP, CHIEF ACCOUNTING OFFICER | Dec 26, 2024 | Dec 27, 2024 | S | 15,000 | $17.22 | Sale −$258,300 | 54,927 | Yes | Form 4 |
| Calvin SandraSVP, CHIEF ACCOUNTING OFFICER | Dec 26, 2024 | Dec 27, 2024 | M · derivative | 15,000 | $12.67 | $190,050 | not reported | Yes | Form 4 |
| Calvin SandraSVP, CHIEF ACCOUNTING OFFICER | Nov 25, 2024 | Nov 25, 2024 | M | 15,000 | $12.67 | $190,050 | 67,017 | No | Form 4 |
| Calvin SandraSVP, CHIEF ACCOUNTING OFFICER | Nov 25, 2024 | Nov 25, 2024 | S | 12,090 | $18.30 | Sale −$221,247 | 54,927 | No | Form 4 |
| Calvin SandraSVP, CHIEF ACCOUNTING OFFICER | Nov 25, 2024 | Nov 25, 2024 | M · derivative | 15,000 | $12.67 | $190,050 | 15,000 | No | Form 4 |
| Lyons Gary A | Oct 4, 2024 | Oct 4, 2024 | M | 40,000 | $10.48 | $419,200 | 91,000 | Yes | Form 4 |
| Lyons Gary A | Oct 4, 2024 | Oct 4, 2024 | S | 21,179 | $14.35 | Sale −$303,919 | 69,821 | Yes | Form 4 |
| Lyons Gary A | Oct 4, 2024 | Oct 4, 2024 | S | 18,821 | $15.15 | Sale −$285,138 | 51,000 | Yes | Form 4 |
| Lyons Gary A | Oct 4, 2024 | Oct 4, 2024 | M · derivative | 40,000 | $10.48 | $419,200 | not reported | Yes | Form 4 |
| Meckler Jeffrey A | Sep 30, 2024 | Sep 30, 2024 | M | 40,000 | $10.48 | $419,200 | 121,000 | Yes | Form 4 |
| Meckler Jeffrey A | Sep 30, 2024 | Sep 30, 2024 | S | 40,000 | $14.06 | Sale −$562,400 | 81,000 | Yes | Form 4 |
| Meckler Jeffrey A | Sep 30, 2024 | Sep 30, 2024 | M · derivative | 40,000 | $10.48 | $419,200 | not reported | Yes | Form 4 |
| Inrig JulaCHIEF MEDICAL OFFICER | Sep 10, 2024 | Sep 10, 2024 | S | 684 | $12.98 | Sale −$8,878 | 61,949 | Yes | Form 4 |
| Cline Christopher R.CHIEF FINANCIAL OFFICER | Sep 9, 2024 | Sep 9, 2024 | S | 2,490 | $11.52 | Sale −$28,685 | 74,595 | No | Form 4 |
| Heerma PeterCHIEF COMMERCIAL OFFICER | Sep 9, 2024 | Sep 9, 2024 | S | 2,191 | $11.52 | Sale −$25,240 | 107,958 | No | Form 4 |
| Inrig JulaCHIEF MEDICAL OFFICER | Sep 9, 2024 | Sep 9, 2024 | S | 2,191 | $11.52 | Sale −$25,240 | 62,633 | No | Form 4 |
| Dube Eric MCHIEF EXECUTIVE OFFICER | Sep 9, 2024 | Sep 9, 2024 | S | 21,125 | $11.52 | Sale −$243,360 | 361,975 | Yes | Form 4 |
| Reed Elizabeth ESVP, GC & CORPORATE SECRETARY | Sep 9, 2024 | Sep 9, 2024 | S | 4,387 | $11.52 | Sale −$50,538 | 78,633 | Yes | Form 4 |
| Rote William E.SENIOR VICE PRESIDENT, R&D | Sep 9, 2024 | Sep 9, 2024 | S | 4,387 | $11.52 | Sale −$50,538 | 84,455 | Yes | Form 4 |
| Cline Christopher R.CHIEF FINANCIAL OFFICER | Sep 5, 2024 | Sep 9, 2024 | A | 6,750 | $0.00 | $0 | 77,085 | No | Form 4 |
| Heerma PeterCHIEF COMMERCIAL OFFICER | Sep 5, 2024 | Sep 9, 2024 | A | 6,750 | $0.00 | $0 | 110,149 | No | Form 4 |
| Inrig JulaCHIEF MEDICAL OFFICER | Sep 5, 2024 | Sep 9, 2024 | A | 6,750 | $0.00 | $0 | 64,824 | No | Form 4 |
| Dube Eric MCHIEF EXECUTIVE OFFICER | Sep 5, 2024 | Sep 9, 2024 | A | 32,500 | $0.00 | $0 | 383,100 | Yes | Form 4 |
| Reed Elizabeth ESVP, GC & CORPORATE SECRETARY | Sep 5, 2024 | Sep 9, 2024 | A | 6,750 | $0.00 | $0 | 83,020 | Yes | Form 4 |
| Rote William E.SENIOR VICE PRESIDENT, R&D | Sep 5, 2024 | Sep 9, 2024 | A | 6,750 | $0.00 | $0 | 88,842 | Yes | Form 4 |
| Cline Christopher R.CHIEF FINANCIAL OFFICER | Sep 4, 2024 | Sep 5, 2024 | S | 514 | $9.51 | Sale −$4,888 | 70,335 | No | Form 4 |
| Baynes Roy D. | May 8, 2024 | May 10, 2024 | A | 6,500 | $0.00 | $0 | 31,000 | No | Form 4 |
| Baynes Roy D. | May 8, 2024 | May 10, 2024 | A · derivative | 19,500 | $6.82 | $132,990 | 19,500 | No | Form 4 |
| Bruhn Suzanne Louise | May 8, 2024 | May 10, 2024 | A | 6,500 | $0.00 | $0 | 22,250 | No | Form 4 |
| Bruhn Suzanne Louise | May 8, 2024 | May 10, 2024 | A · derivative | 19,500 | $6.82 | $132,990 | 19,500 | No | Form 4 |
| Coughlin Timothy | May 8, 2024 | May 10, 2024 | A | 6,500 | $0.00 | $0 | 49,000 | No | Form 4 |
| Coughlin Timothy | May 8, 2024 | May 10, 2024 | A · derivative | 19,500 | $6.82 | $132,990 | 19,500 | No | Form 4 |
| Lyons Gary A | May 8, 2024 | May 10, 2024 | A | 6,500 | $0.00 | $0 | 51,000 | No | Form 4 |
| Lyons Gary A | May 8, 2024 | May 10, 2024 | A · derivative | 19,500 | $6.82 | $132,990 | 19,500 | No | Form 4 |
| Meckler Jeffrey A | May 8, 2024 | May 10, 2024 | A | 6,500 | $0.00 | $0 | 81,000 | No | Form 4 |
| Meckler Jeffrey A | May 8, 2024 | May 10, 2024 | A · derivative | 19,500 | $6.82 | $132,990 | 19,500 | No | Form 4 |
| Orwin John A | May 8, 2024 | May 10, 2024 | A | 6,500 | $0.00 | $0 | 28,875 | No | Form 4 |
| Orwin John A | May 8, 2024 | May 10, 2024 | A · derivative | 19,500 | $6.82 | $132,990 | 19,500 | No | Form 4 |
| Poole Sandra | May 8, 2024 | May 10, 2024 | A | 6,500 | $0.00 | $0 | 23,500 | No | Form 4 |
| Poole Sandra | May 8, 2024 | May 10, 2024 | A · derivative | 19,500 | $6.82 | $132,990 | 19,500 | No | Form 4 |
| Squarer Ron | May 8, 2024 | May 10, 2024 | A | 6,500 | $0.00 | $0 | 28,875 | No | Form 4 |
| Squarer Ron | May 8, 2024 | May 10, 2024 | A · derivative | 19,500 | $6.82 | $132,990 | 19,500 | No | Form 4 |
| Williams Brinkley Ruth | May 8, 2024 | May 10, 2024 | A | 6,500 | $0.00 | $0 | 19,250 | No | Form 4 |
| Williams Brinkley Ruth | May 8, 2024 | May 10, 2024 | A · derivative | 19,500 | $6.82 | $132,990 | 19,500 | No | Form 4 |
| Cline Christopher R.CHIEF FINANCIAL OFFICER | Apr 11, 2024 | Apr 12, 2024 | S | 54 | $6.74 | Sale −$364 | 70,849 | No | Form 4 |
| Calvin SandraSVP, CHIEF ACCOUNTING OFFICER | Feb 1, 2024 | Feb 2, 2024 | S | 2,820 | $8.53 | Sale −$24,055 | 52,017 | No | Form 4 |
| Cline Christopher R.CHIEF FINANCIAL OFFICER | Feb 1, 2024 | Feb 2, 2024 | S | 3,818 | $8.53 | Sale −$32,568 | 70,903 | No | Form 4 |
| Inrig JulaCHIEF MEDICAL OFFICER | Feb 1, 2024 | Feb 2, 2024 | S | 2,174 | $8.53 | Sale −$18,544 | 58,074 | No | Form 4 |
| Heerma PeterCHIEF COMMERCIAL OFFICER | Feb 1, 2024 | Feb 2, 2024 | S | 4,195 | $8.53 | Sale −$35,783 | 99,503 | No | Form 4 |
| Reed Elizabeth ESVP, GC & CORPORATE SECRETARY | Feb 1, 2024 | Feb 2, 2024 | S | 2,174 | $8.53 | Sale −$18,544 | 78,860 | No | Form 4 |
| Reed Elizabeth ESVP, GC & CORPORATE SECRETARY | Feb 1, 2024 | Feb 2, 2024 | S | 2,590 | $8.86 | Sale −$22,947 | 76,270 | No | Form 4 |
| Rote William E.SENIOR VICE PRESIDENT, R&D | Feb 1, 2024 | Feb 2, 2024 | S | 2,174 | $8.53 | Sale −$18,544 | 83,310 | No | Form 4 |
| Rote William E.SENIOR VICE PRESIDENT, R&D | Feb 1, 2024 | Feb 2, 2024 | S | 2,590 | $8.86 | Sale −$22,947 | 80,720 | No | Form 4 |
| Dube Eric MCHIEF EXECUTIVE OFFICER | Feb 1, 2024 | Feb 2, 2024 | S | 9,106 | $8.53 | Sale −$77,674 | 360,616 | No | Form 4 |
| Dube Eric MCHIEF EXECUTIVE OFFICER | Feb 1, 2024 | Feb 2, 2024 | S | 10,016 | $8.86 | Sale −$88,742 | 350,600 | No | Form 4 |
| Calvin SandraSVP, CHIEF ACCOUNTING OFFICER | Jan 31, 2024 | Feb 2, 2024 | A | 12,500 | $0.00 | $0 | 53,837 | No | Form 4 |
| Calvin SandraSVP, CHIEF ACCOUNTING OFFICER | Jan 31, 2024 | Feb 2, 2024 | A | 1,000 | $0.00 | $0 | 54,837 | No | Form 4 |
| Calvin SandraSVP, CHIEF ACCOUNTING OFFICER | Jan 31, 2024 | Feb 2, 2024 | A · derivative | 25,000 | $8.93 | $223,250 | 25,000 | No | Form 4 |
| Cline Christopher R.CHIEF FINANCIAL OFFICER | Jan 31, 2024 | Feb 2, 2024 | A | 25,000 | $0.00 | $0 | 74,721 | No | Form 4 |
| Cline Christopher R.CHIEF FINANCIAL OFFICER | Jan 31, 2024 | Feb 2, 2024 | A · derivative | 65,000 | $8.93 | $580,450 | 65,000 | No | Form 4 |
| Inrig JulaCHIEF MEDICAL OFFICER | Jan 31, 2024 | Feb 2, 2024 | A | 25,000 | $0.00 | $0 | 60,248 | No | Form 4 |
| Inrig JulaCHIEF MEDICAL OFFICER | Jan 31, 2024 | Feb 2, 2024 | A · derivative | 91,000 | $8.93 | $812,630 | 91,000 | No | Form 4 |
| Heerma PeterCHIEF COMMERCIAL OFFICER | Jan 31, 2024 | Feb 2, 2024 | A | 25,000 | $0.00 | $0 | 103,698 | No | Form 4 |
| Heerma PeterCHIEF COMMERCIAL OFFICER | Jan 31, 2024 | Feb 2, 2024 | A · derivative | 65,000 | $8.93 | $580,450 | 65,000 | No | Form 4 |
| Reed Elizabeth ESVP, GC & CORPORATE SECRETARY | Jan 31, 2024 | Feb 2, 2024 | A | 25,000 | $0.00 | $0 | 81,034 | No | Form 4 |
| Reed Elizabeth ESVP, GC & CORPORATE SECRETARY | Jan 31, 2024 | Feb 2, 2024 | A · derivative | 65,000 | $8.93 | $580,450 | 65,000 | No | Form 4 |
| Rote William E.SENIOR VICE PRESIDENT, R&D | Jan 31, 2024 | Feb 2, 2024 | A | 25,000 | $0.00 | $0 | 85,484 | No | Form 4 |
| Rote William E.SENIOR VICE PRESIDENT, R&D | Jan 31, 2024 | Feb 2, 2024 | A · derivative | 65,000 | $8.93 | $580,450 | 65,000 | No | Form 4 |
| Dube Eric MCHIEF EXECUTIVE OFFICER | Jan 31, 2024 | Feb 2, 2024 | A | 135,000 | $0.00 | $0 | 369,722 | No | Form 4 |
| Dube Eric MCHIEF EXECUTIVE OFFICER | Jan 31, 2024 | Feb 2, 2024 | A · derivative | 360,000 | $8.93 | $3,214,800 | 360,000 | No | Form 4 |
| Calvin SandraSVP, CHIEF ACCOUNTING OFFICER | Jan 23, 2024 | Jan 25, 2024 | S | 910 | $9.07 | Sale −$8,254 | 41,337 | No | Form 4 |
| Heerma PeterCHIEF COMMERCIAL OFFICER | Jan 23, 2024 | Jan 25, 2024 | S | 1,559 | $9.07 | Sale −$14,140 | 78,698 | No | Form 4 |
| Cline Christopher R.CHIEF FINANCIAL OFFICER | Jan 23, 2024 | Jan 25, 2024 | S | 853 | $9.07 | Sale −$7,737 | 49,721 | No | Form 4 |
| Dube Eric MCHIEF EXECUTIVE OFFICER | Jan 23, 2024 | Jan 25, 2024 | S | 7,873 | $8.96 | Sale −$70,542 | 234,722 | No | Form 4 |
| Rote William E.SENIOR VICE PRESIDENT, R&D | Jan 23, 2024 | Jan 25, 2024 | S | 2,062 | $8.96 | Sale −$18,476 | 60,484 | No | Form 4 |
| Reed Elizabeth ESVP, GC & CORPORATE SECRETARY | Jan 23, 2024 | Jan 25, 2024 | S | 2,062 | $8.96 | Sale −$18,476 | 56,034 | No | Form 4 |
| Inrig JulaChief Medical Officer | Jan 4, 2024 | Jan 5, 2024 | S | 440 | $9.17 | Sale −$4,035 | 35,248 | No | Form 4 |
| Inrig JulaChief Medical Officer | Jan 3, 2024 | Jan 5, 2024 | S | 2,069 | $9.48 | Sale −$19,614 | 35,688 | No | Form 4 |