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UPBUpstream Bio, Inc.

Market cap
$150.07M
as of 2026-10-23
Latest close
$2.74
as of 2026-10-23
Sector
Healthcare
as of 2026-10-24
Industry
Biotechnology
as of 2026-10-24

Cluster

No cluster in the last 90 days under the default rule (14d · ≥2 insiders · all roles).

Form 4 historysince 2024-10-15

InsiderTradedFiledTypeSharesPriceValueOwned after10b5-1 planFiling
Ambrose AllisonGeneral CounselSep 16Sep 17S485$5.49Sale −$2,66315,563NoForm 4
Gray MichaelCFO and COOSep 16Sep 17S853$5.49Sale −$4,68327,942NoForm 4
Houghton AdamChief Business OfficerSep 16Sep 17S700$5.49Sale −$3,84322,901NoForm 4
Sutherland Everett RandChief Executive OfficerSep 16Sep 17S2,095$5.49Sale −$11,50268,717NoForm 4
Deykin AaronChief Medical OfficerSep 16Sep 17S895$5.49Sale −$4,91432,302NoForm 4
Ambrose AllisonGeneral CounselJun 16Jun 17S477$6.10Sale −$2,91016,048NoForm 4
Deykin AaronChief Medical OfficerJun 16Jun 17S895$6.10Sale −$5,46033,197NoForm 4
Houghton AdamChief Business OfficerJun 16Jun 17S700$6.10Sale −$4,27023,601NoForm 4
Sutherland Everett RandChief Executive OfficerJun 16Jun 17S2,095$6.10Sale −$12,78070,812NoForm 4
Gray MichaelCFO and COOJun 16Jun 17S853$6.10Sale −$5,20328,795NoForm 4
Chimovits ErezJun 9Jun 11A · derivative17,096$6.69$114,37217,096NoForm 4
Ratcliffe LiamJun 9Jun 11A · derivative17,096$6.69$114,37217,096NoForm 4
Beckman DaniellaJun 9Jun 11A · derivative17,096$6.69$114,37217,096NoForm 4
Fleming Harold EdwardJun 9Jun 11A · derivative17,096$6.69$114,37217,096NoForm 4
Renaud Ronald C JRJun 9Jun 11A · derivative17,096$6.69$114,37217,096NoForm 4
Ruddy Marcella K.Jun 9Jun 11A · derivative17,096$6.69$114,37217,096NoForm 4
Houghton AdamChief Business OfficerMar 16Mar 17S699$9.29Sale −$6,49424,301NoForm 4
Ambrose AllisonGeneral CounselMar 16Mar 17S475$9.29Sale −$4,41316,525NoForm 4
Sutherland Everett RandChief Executive OfficerMar 16Mar 17S2,093$9.29Sale −$19,44472,907NoForm 4
Deykin AaronChief Medical OfficerMar 16Mar 17S894$9.29Sale −$8,30532,687NoForm 4
Gray MichaelCFO and COOMar 16Mar 17S852$9.29Sale −$7,91529,648NoForm 4
Sutherland Everett RandChief Executive OfficerJan 2Jan 6A75,000$0.00$075,000NoForm 4
Sutherland Everett RandChief Executive OfficerJan 2Jan 6A · derivative225,000$27.07$6,090,750225,000NoForm 4
Houghton AdamChief Business OfficerJan 2Jan 6A25,000$0.00$025,000NoForm 4
Houghton AdamChief Business OfficerJan 2Jan 6A · derivative75,000$27.07$2,030,25075,000NoForm 4
Ambrose AllisonGeneral CounselJan 2Jan 6A17,000$0.00$017,000NoForm 4
Ambrose AllisonGeneral CounselJan 2Jan 6A · derivative51,000$27.07$1,380,57051,000NoForm 4
Deykin AaronChief Medical OfficerJan 2Jan 6A32,000$0.00$033,581NoForm 4
Deykin AaronChief Medical OfficerJan 2Jan 6A · derivative96,000$27.07$2,598,72096,000NoForm 4
Gray MichaelCFO and COOJan 2Jan 6A30,500$0.00$030,500NoForm 4
Gray MichaelCFO and COOJan 2Jan 6A · derivative91,500$27.07$2,476,90591,500NoForm 4
Ratcliffe LiamJun 10, 2025Jun 12, 2025A · derivative17,096$11.59$198,14317,096NoForm 4
Chimovits ErezJun 10, 2025Jun 12, 2025A · derivative17,096$11.59$198,14317,096NoForm 4
Fleming Harold EdwardJun 10, 2025Jun 12, 2025A · derivative17,096$11.59$198,14317,096NoForm 4
Renaud Ronald C JRJun 10, 2025Jun 12, 2025A · derivative17,096$11.59$198,14317,096NoForm 4
Beckman DaniellaJun 10, 2025Jun 12, 2025A · derivative17,096$11.59$198,14317,096NoForm 4
Ruddy Marcella K.Jun 10, 2025Jun 12, 2025A · derivative17,096$11.59$198,14317,096NoForm 4
Ambrose AllisonGeneral CounselFeb 6, 2025Feb 7, 2025A · derivative25,000$8.53$213,25025,000NoForm 4
Deykin AaronChief Medical OfficerFeb 6, 2025Feb 7, 2025A · derivative165,000$8.53$1,407,450165,000NoForm 4
Houghton AdamChief Business OfficerFeb 6, 2025Feb 7, 2025A · derivative140,000$8.53$1,194,200140,000NoForm 4
Gray MichaelCFO and COOFeb 6, 2025Feb 7, 2025A · derivative195,000$8.53$1,663,350195,000NoForm 4
Sutherland Everett RandChief Executive OfficerFeb 6, 2025Feb 7, 2025A · derivative500,000$8.53$4,265,000500,000NoForm 4
Ambrose AllisonGeneral CounselDec 16, 2024Dec 17, 2024A · derivative100,000$19.01$1,901,000100,000NoForm 4
Orbimed Advisors LLCOct 15, 2024Oct 17, 2024C721,956not reportednot reported973,716NoForm 4
Orbimed Advisors LLCOct 15, 2024Oct 17, 2024P165,000$17.00Purchase +$2,805,0001,138,716NoForm 4
Orbimed Advisors LLCOct 15, 2024Oct 17, 2024C2,887,833not reportednot reported3,894,873NoForm 4
Orbimed Advisors LLCOct 15, 2024Oct 17, 2024P660,000$17.00Purchase +$11,220,0004,554,873NoForm 4
Orbimed Advisors LLCOct 15, 2024Oct 17, 2024C · derivative524,500not reportednot reportednot reportedNoForm 4
Orbimed Advisors LLCOct 15, 2024Oct 17, 2024C · derivative2,098,000not reportednot reportednot reportedNoForm 4
Orbimed Advisors LLCOct 15, 2024Oct 17, 2024C · derivative197,456not reportednot reportednot reportedNoForm 4
Orbimed Advisors LLCOct 15, 2024Oct 17, 2024C · derivative789,833not reportednot reportednot reportedNoForm 4
Chimovits ErezOct 15, 2024Oct 17, 2024C721,956not reportednot reported973,716NoForm 4
Chimovits ErezOct 15, 2024Oct 17, 2024P165,000$17.00Purchase +$2,805,0001,138,716NoForm 4
Chimovits ErezOct 15, 2024Oct 17, 2024C2,887,833not reportednot reported3,894,873NoForm 4
Chimovits ErezOct 15, 2024Oct 17, 2024P660,000$17.00Purchase +$11,220,0004,554,873NoForm 4
Chimovits ErezOct 15, 2024Oct 17, 2024C · derivative524,500not reportednot reportednot reportedNoForm 4
Chimovits ErezOct 15, 2024Oct 17, 2024C · derivative2,098,000not reportednot reportednot reportedNoForm 4
Chimovits ErezOct 15, 2024Oct 17, 2024C · derivative197,456not reportednot reportednot reportedNoForm 4
Chimovits ErezOct 15, 2024Oct 17, 2024C · derivative789,833not reportednot reportednot reportedNoForm 4
Access Industries Holdings LLCOct 15, 2024Oct 17, 2024P1,175,000$17.00Purchase +$19,975,0001,175,000YesForm 4
Access Industries Holdings LLCOct 15, 2024Oct 17, 2024C3,147,000not reportednot reported4,322,000YesForm 4
Access Industries Holdings LLCOct 15, 2024Oct 17, 2024C1,172,410not reportednot reported5,494,410YesForm 4
Access Industries Holdings LLCOct 15, 2024Oct 17, 2024C · derivative3,147,000not reportednot reportednot reportedYesForm 4
Access Industries Holdings LLCOct 15, 2024Oct 17, 2024C · derivative1,172,410not reportednot reportednot reportedYesForm 4
Wellington Biomedical Innovation Master Investors (Cayman) II L.P.Oct 15, 2024Oct 15, 2024C894,733not reportednot reported894,733NoForm 4
Wellington Biomedical Innovation Master Investors (Cayman) II L.P.Oct 15, 2024Oct 15, 2024C · derivative852,940$0.00$0not reportedNoForm 4
Ratcliffe LiamOct 10, 2024Oct 15, 2024A · derivative17,096$17.00$290,63217,096NoForm 4
Fleming Harold EdwardOct 10, 2024Oct 15, 2024A · derivative17,096$17.00$290,63217,096NoForm 4
Ruddy Marcella K.Oct 10, 2024Oct 15, 2024A · derivative17,096$17.00$290,63217,096NoForm 4
Chimovits ErezOct 10, 2024Oct 15, 2024A · derivative17,096$17.00$290,63217,096NoForm 4
Beckman DaniellaOct 10, 2024Oct 15, 2024A · derivative34,681$17.00$589,57734,681NoForm 4
Renaud Ronald C JROct 10, 2024Oct 15, 2024A · derivative17,096$17.00$290,63217,096NoForm 4