VRTXVERTEX PHARMACEUTICALS INC / MA
- Market cap
- $132.71B
- as of 2026-10-23
- Latest close
- $523.93
- as of 2026-10-23
- Sector
- Healthcare
- as of 2026-10-24
- Industry
- Biotechnology
- as of 2026-10-24
Cluster
No cluster in the last 90 days under the default rule (14d · ≥2 insiders · all roles).
Form 4 historysince 2023-10-03
Showing the latest 500 of 539 transactions.
| Insider | Traded | Filed | Type | Shares | Price | Value | Owned after | 10b5-1 plan | Filing |
|---|---|---|---|---|---|---|---|---|---|
| Brennan Daniel J. | Oct 20 | Oct 22 | A | 795 | $503.47 | $400,259 | 795 | No | Form 4 |
| Sachs Bruce I | Oct 15 | Oct 19 | A · derivative | 92.69 | $512.44 | $47,500 | 15,864.5 | No | Form 4 |
| Garber Alan M | Oct 15 | Oct 19 | A · derivative | 29.27 | $512.44 | $15,000 | 94.73 | No | Form 4 |
| van Grunsven JasperEVP, CP and NPPO | Sep 8 | Sep 10 | A | 8,682 | $0.00 | $0 | 8,682 | No | Form 4 |
| Ambrose KristenSVP & Chief Accounting Officer | Aug 28 | Sep 1 | A | 5,000 | $0.00 | $0 | 11,624 | No | Form 4 |
| Sachs Bruce I | Aug 27 | Aug 31 | G | 6,000 | $0.00 | $0 | 39,000 | No | Form 4 |
| Sachdev AmitEVP Chief Patient & Ext Af Off | Jul 21 | Jul 23 | A | 8,251 | $0.00 | $0 | 66,512 | No | Form 4 |
| Tatsis OuraniaEVP, Chief Reg. & Quality Off. | Jul 21 | Jul 23 | A | 8,251 | $0.00 | $0 | 53,572 | No | Form 4 |
| Garber Alan M | Jul 15 | Jul 17 | A · derivative | 31.56 | $475.28 | $15,000 | 65.46 | No | Form 4 |
| Sachs Bruce I | Jul 15 | Jul 17 | A · derivative | 99.94 | $475.28 | $47,499 | 15,771.81 | No | Form 4 |
| McKechnie DuncanEVP, Chief Commercial Officer | Jul 2 | Jul 7 | S | 1,541 | $519.00 | Sale −$799,779 | 11,001 | Yes | Form 4 |
| Tatsis OuraniaEVP, Chief Reg. & Quality Off. | Jul 2 | Jul 7 | S | 1,500 | $524.99 | Sale −$787,485 | 45,321 | Yes | Form 4 |
| Liu JoyEVP and Chief Legal Officer | Jul 1 | Jul 6 | S | 828 | $502.71 | Sale −$416,244 | 19,131 | Yes | Form 4 |
| Bozic CarmenEVP and CMO | Jun 26 | Jun 30 | S | 596 | $482.50 | Sale −$287,570 | 15,337 | Yes | Form 4 |
| Bozic CarmenEVP and CMO | Jun 18 | Jun 23 | S | 1,020 | $462.17 | Sale −$471,413 | 15,933 | Yes | Form 4 |
| Bozic CarmenEVP and CMO | Jun 15 | Jun 17 | S | 4,062 | $450.00 | Sale −$1,827,900 | 16,953 | Yes | Form 4 |
| Bozic CarmenEVP and CMO | Jun 5 | Jun 9 | S | 1,745 | $450.00 | Sale −$785,250 | 21,015 | Yes | Form 4 |
| Liu JoyEVP and Chief Legal Officer | Jun 1 | Jun 3 | S | 828 | $439.91 | Sale −$364,245 | 19,959 | Yes | Form 4 |
| Bozic CarmenEVP and CMO | May 29 | Jun 2 | S | 1,974 | $450.00 | Sale −$888,300 | 22,760 | Yes | Form 4 |
| Bozic CarmenEVP and CMO | May 15 | May 19 | S | 1,354 | $453.45 | Sale −$613,971 | 24,734 | Yes | Form 4 |
| Bunnage Mark E.EVP, Chief Scientific Officer | May 15 | May 19 | S | 33 | $453.45 | Sale −$14,964 | 7,284 | Yes | Form 4 |
| Bozic CarmenEVP and CMO | May 12 | May 14 | S | 6,988 | $450.00 | Sale −$3,144,600 | 26,088 | Yes | Form 4 |
| Bhatia Sangeeta N. | May 4 | May 5 | S | 318 | $423.73 | Sale −$134,746 | 4,924 | Yes | Form 4 |
| Bhatia Sangeeta N. | May 1 | May 5 | A | 943 | $0.00 | $0 | 5,242 | Yes | Form 4 |
| Carney Lloyd | May 1 | May 5 | A · derivative | 2,866 | $424.45 | $1,216,474 | 2,866 | No | Form 4 |
| Garber Alan M | May 1 | May 5 | A | 472 | $0.00 | $0 | 7,344 | No | Form 4 |
| Garber Alan M | May 1 | May 5 | A · derivative | 1,433 | $424.45 | $608,237 | 1,433 | No | Form 4 |
| Lagarde Michel | May 1 | May 5 | A · derivative | 2,866 | $424.45 | $1,216,474 | 2,866 | No | Form 4 |
| Liu JoyEVP and Chief Legal Officer | May 1 | May 5 | S | 1,104 | $425.02 | Sale −$469,222 | 20,729 | Yes | Form 4 |
| Mckenzie Diana | May 1 | May 5 | A | 943 | $0.00 | $0 | 3,174 | No | Form 4 |
| Mckenzie Diana | May 1 | May 5 | D | 796 | not reported | not reported | 2,378 | No | Form 4 |
| Mckenzie Diana | May 1 | May 5 | A · derivative | 796 | not reported | not reported | 7,787.48 | No | Form 4 |
| Sachs Bruce I | May 1 | May 5 | A · derivative | 2,866 | $424.45 | $1,216,474 | 2,866 | No | Form 4 |
| Schneider Jennifer | May 1 | May 5 | A | 472 | $0.00 | $0 | 2,190 | No | Form 4 |
| Schneider Jennifer | May 1 | May 5 | D | 796 | not reported | not reported | 1,394 | No | Form 4 |
| Schneider Jennifer | May 1 | May 5 | A · derivative | 1,433 | $424.45 | $608,237 | 1,433 | No | Form 4 |
| Schneider Jennifer | May 1 | May 5 | A · derivative | 796 | not reported | not reported | 796 | No | Form 4 |
| Thornberry Nancy | May 1 | May 5 | A | 472 | $0.00 | $0 | 2,507 | No | Form 4 |
| Thornberry Nancy | May 1 | May 5 | D | 398 | not reported | not reported | 2,109 | No | Form 4 |
| Thornberry Nancy | May 1 | May 5 | A · derivative | 1,433 | $424.45 | $608,237 | 1,433 | No | Form 4 |
| Thornberry Nancy | May 1 | May 5 | A · derivative | 398 | not reported | not reported | 398 | No | Form 4 |
| Upadhyay Suketu | May 1 | May 5 | D | 796 | not reported | not reported | 1,558 | No | Form 4 |
| Upadhyay Suketu | May 1 | May 5 | A · derivative | 2,866 | $424.45 | $1,216,474 | 2,866 | No | Form 4 |
| Upadhyay Suketu | May 1 | May 5 | A · derivative | 796 | not reported | not reported | 3,595.16 | No | Form 4 |
| Garber Alan M | Apr 15 | Apr 17 | A · derivative | 33.9 | $442.50 | $15,001 | 33.9 | No | Form 4 |
| Sachs Bruce I | Apr 15 | Apr 17 | A · derivative | 107.35 | $442.50 | $47,502 | 15,671.87 | No | Form 4 |
| Upadhyay Suketu | Apr 15 | Apr 17 | A · derivative | 80.51 | $442.50 | $35,626 | 2,799.16 | No | Form 4 |
| Liu JoyEVP and Chief Legal Officer | Apr 1 | Apr 3 | S | 978 | $449.17 | Sale −$439,288 | 21,833 | Yes | Form 4 |
| Bozic CarmenEVP and CMO | Mar 27 | Mar 31 | S | 2,329 | $450.95 | Sale −$1,050,263 | 33,076 | Yes | Form 4 |
| Bozic CarmenEVP and CMO | Mar 13 | Mar 17 | S | 2,329 | $481.79 | Sale −$1,122,089 | 35,405 | Yes | Form 4 |
| McKechnie DuncanEVP, Chief Commercial Officer | Mar 11 | Mar 13 | S | 2,633 | $498.42 | Sale −$1,312,340 | 12,489 | Yes | Form 4 |
| McKechnie DuncanEVP, Chief Commercial Officer | Mar 4 | Mar 6 | S | 2,437 | $475.30 | Sale −$1,158,306 | 15,122 | Yes | Form 4 |
| Liu JoyEVP and Chief Legal Officer | Mar 2 | Mar 4 | S | 892 | $495.96 | Sale −$442,396 | 22,811 | Yes | Form 4 |
| Bozic CarmenEVP and CMO | Feb 27 | Mar 3 | S | 2,329 | $480.31 | Sale −$1,118,642 | 37,734 | Yes | Form 4 |
| Kewalramani ReshmaCEO & President | Feb 27 | Mar 3 | S | 400 | $479.75 | Sale −$191,900 | 137,878 | Yes | Form 4 |
| Kewalramani ReshmaCEO & President | Feb 27 | Mar 3 | S | 120 | $481.50 | Sale −$57,780 | 137,758 | Yes | Form 4 |
| Kewalramani ReshmaCEO & President | Feb 27 | Mar 3 | S | 240 | $482.84 | Sale −$115,882 | 137,518 | Yes | Form 4 |
| Kewalramani ReshmaCEO & President | Feb 27 | Mar 3 | S | 2,510 | $487.13 | Sale −$1,222,696 | 135,008 | Yes | Form 4 |
| Kewalramani ReshmaCEO & President | Feb 27 | Mar 3 | S | 3,278 | $488.27 | Sale −$1,600,549 | 131,730 | Yes | Form 4 |
| Kewalramani ReshmaCEO & President | Feb 27 | Mar 3 | S | 460 | $489.32 | Sale −$225,087 | 131,270 | Yes | Form 4 |
| Kewalramani ReshmaCEO & President | Feb 27 | Mar 3 | S | 2,725 | $490.54 | Sale −$1,336,722 | 128,545 | Yes | Form 4 |
| Kewalramani ReshmaCEO & President | Feb 27 | Mar 3 | S | 949 | $491.30 | Sale −$466,244 | 127,596 | Yes | Form 4 |
| Kewalramani ReshmaCEO & President | Feb 27 | Mar 3 | S | 2,520 | $493.29 | Sale −$1,243,091 | 125,076 | Yes | Form 4 |
| Kewalramani ReshmaCEO & President | Feb 27 | Mar 3 | S | 3,498 | $494.33 | Sale −$1,729,166 | 121,578 | Yes | Form 4 |
| Kewalramani ReshmaCEO & President | Feb 27 | Mar 3 | S | 15,580 | $495.38 | Sale −$7,718,020 | 105,998 | Yes | Form 4 |
| Kewalramani ReshmaCEO & President | Feb 27 | Mar 3 | S | 5,995 | $496.16 | Sale −$2,974,479 | 100,003 | Yes | Form 4 |
| Kewalramani ReshmaCEO & President | Feb 27 | Mar 3 | S | 1,725 | $496.95 | Sale −$857,239 | 98,278 | Yes | Form 4 |
| Ambrose KristenSVP & Chief Accounting Officer | Feb 26 | Mar 2 | S | 357 | $483.36 | Sale −$172,560 | 6,624 | Yes | Form 4 |
| Ambrose KristenSVP & Chief Accounting Officer | Feb 25 | Feb 26 | S | 223 | $486.35 | Sale −$108,456 | 6,981 | Yes | Form 4 |
| Atkinson Edward Morrow IIIEVP, Chief Technical Ops. Off. | Feb 25 | Feb 26 | S | 668 | $486.35 | Sale −$324,882 | 18,432 | Yes | Form 4 |
| Biller JonathanEVP and Chief Legal Officer | Feb 25 | Feb 26 | S | 945 | $486.35 | Sale −$459,601 | 13,659 | Yes | Form 4 |
| Bunnage Mark E.EVP, Chief Scientific Officer | Feb 25 | Feb 26 | S | 620 | $486.35 | Sale −$301,537 | 7,284 | Yes | Form 4 |
| McKechnie DuncanEVP, Chief Commercial Officer | Feb 25 | Feb 26 | S | 2,500 | $486.35 | Sale −$1,215,875 | 19,969 | Yes | Form 4 |
| McKechnie DuncanEVP, Chief Commercial Officer | Feb 25 | Feb 26 | S | 2,410 | $489.00 | Sale −$1,178,490 | 17,559 | Yes | Form 4 |
| Sachdev AmitEVP Chief Patient & Ext Af Off | Feb 25 | Feb 26 | S | 1,846 | $486.35 | Sale −$897,802 | 55,570 | Yes | Form 4 |
| Tatsis OuraniaEVP, Chief Reg. & Quality Off. | Feb 25 | Feb 26 | S | 260 | $486.35 | Sale −$126,451 | 46,763 | Yes | Form 4 |
| Ambrose KristenSVP & Chief Accounting Officer | Feb 24 | Feb 26 | F | 546 | $485.11 | $264,870 | 7,204 | Yes | Form 4 |
| Atkinson Edward Morrow IIIEVP, Chief Technical Ops. Off. | Feb 24 | Feb 26 | F | 1,627 | $485.11 | $789,274 | 19,100 | Yes | Form 4 |
| Biller JonathanEVP and Chief Legal Officer | Feb 24 | Feb 26 | F | 1,144 | $485.11 | $554,966 | 14,604 | Yes | Form 4 |
| Bozic CarmenEVP and CMO | Feb 24 | Feb 26 | F | 1,453 | $485.11 | $704,865 | 40,063 | No | Form 4 |
| Bunnage Mark E.EVP, Chief Scientific Officer | Feb 24 | Feb 26 | F | 582 | $485.11 | $282,334 | 7,904 | Yes | Form 4 |
| Kewalramani ReshmaCEO & President | Feb 24 | Feb 26 | F | 4,981 | $485.11 | $2,416,333 | 138,278 | No | Form 4 |
| McKechnie DuncanEVP, Chief Commercial Officer | Feb 24 | Feb 26 | F | 873 | $485.11 | $423,501 | 22,469 | Yes | Form 4 |
| Sachdev AmitEVP Chief Patient & Ext Af Off | Feb 24 | Feb 26 | F | 1,518 | $485.11 | $736,397 | 57,416 | Yes | Form 4 |
| Tatsis OuraniaEVP, Chief Reg. & Quality Off. | Feb 24 | Feb 26 | F | 1,627 | $485.11 | $789,274 | 47,023 | Yes | Form 4 |
| Wagner Charles F JrEVP, CO & FO | Feb 24 | Feb 26 | F | 1,744 | $485.11 | $846,032 | 47,042 | No | Form 4 |
| Leiden Jeffrey MExecutive Chairman | Feb 24 | Feb 26 | F | 3,547 | $485.11 | $1,720,685 | 34,797 | No | Form 4 |
| Sachdev AmitEVP Chief Patient & Ext Af Off | Feb 19 | Feb 23 | M | 23,479 | $155.57 | $3,652,628 | 92,521 | Yes | Form 4 |
| Sachdev AmitEVP Chief Patient & Ext Af Off | Feb 19 | Feb 23 | M | 25,026 | $187.53 | $4,693,126 | 117,547 | Yes | Form 4 |
| Sachdev AmitEVP Chief Patient & Ext Af Off | Feb 19 | Feb 23 | S | 920 | $463.91 | Sale −$426,797 | 116,627 | Yes | Form 4 |
| Sachdev AmitEVP Chief Patient & Ext Af Off | Feb 19 | Feb 23 | S | 2,730 | $465.05 | Sale −$1,269,587 | 113,897 | Yes | Form 4 |
| Sachdev AmitEVP Chief Patient & Ext Af Off | Feb 19 | Feb 23 | S | 1,848 | $465.80 | Sale −$860,798 | 112,049 | Yes | Form 4 |
| Sachdev AmitEVP Chief Patient & Ext Af Off | Feb 19 | Feb 23 | S | 10,263 | $467.75 | Sale −$4,800,518 | 101,786 | Yes | Form 4 |
| Sachdev AmitEVP Chief Patient & Ext Af Off | Feb 19 | Feb 23 | S | 19,662 | $468.57 | Sale −$9,213,023 | 82,124 | Yes | Form 4 |
| Sachdev AmitEVP Chief Patient & Ext Af Off | Feb 19 | Feb 23 | S | 7,241 | $469.61 | Sale −$3,400,446 | 74,883 | Yes | Form 4 |
| Sachdev AmitEVP Chief Patient & Ext Af Off | Feb 19 | Feb 23 | S | 11,712 | $470.54 | Sale −$5,510,964 | 63,171 | Yes | Form 4 |
| Sachdev AmitEVP Chief Patient & Ext Af Off | Feb 19 | Feb 23 | S | 4,237 | $471.43 | Sale −$1,997,449 | 58,934 | Yes | Form 4 |
| Sachdev AmitEVP Chief Patient & Ext Af Off | Feb 19 | Feb 23 | M · derivative | 23,479 | $155.57 | $3,652,628 | not reported | Yes | Form 4 |
| Sachdev AmitEVP Chief Patient & Ext Af Off | Feb 19 | Feb 23 | M · derivative | 25,026 | $187.53 | $4,693,126 | not reported | Yes | Form 4 |
| Ambrose KristenSVP & Chief Accounting Officer | Feb 18 | Feb 19 | S | 638 | $473.68 | Sale −$302,208 | 7,750 | Yes | Form 4 |
| Atkinson Edward Morrow IIIEVP, Chief Technical Ops. Off. | Feb 18 | Feb 19 | S | 817 | $473.68 | Sale −$386,997 | 20,727 | Yes | Form 4 |
| Biller JonathanEVP and Chief Legal Officer | Feb 18 | Feb 19 | S | 1,244 | $473.68 | Sale −$589,258 | 15,748 | Yes | Form 4 |
| Bunnage Mark E.EVP, Chief Scientific Officer | Feb 18 | Feb 19 | S | 1,182 | $473.68 | Sale −$559,890 | 8,486 | Yes | Form 4 |
| Leiden Jeffrey MExecutive Chairman | Feb 18 | Feb 19 | F | 2,964 | $483.75 | $1,433,835 | 38,344 | No | Form 4 |
| Tatsis OuraniaEVP, Chief Reg. & Quality Off. | Feb 18 | Feb 19 | S | 368 | $473.68 | Sale −$174,314 | 48,650 | Yes | Form 4 |
| Ambrose KristenSVP & Chief Accounting Officer | Feb 17 | Feb 19 | A | 1,809 | $0.00 | $0 | 10,543 | Yes | Form 4 |
| Ambrose KristenSVP & Chief Accounting Officer | Feb 17 | Feb 19 | F | 598 | $483.75 | $289,283 | 9,945 | Yes | Form 4 |
| Ambrose KristenSVP & Chief Accounting Officer | Feb 17 | Feb 19 | S | 1,557 | $489.46 | Sale −$762,089 | 8,388 | Yes | Form 4 |
| Atkinson Edward Morrow IIIEVP, Chief Technical Ops. Off. | Feb 17 | Feb 19 | A | 4,962 | $0.00 | $0 | 25,105 | Yes | Form 4 |
| Atkinson Edward Morrow IIIEVP, Chief Technical Ops. Off. | Feb 17 | Feb 19 | F | 1,530 | $483.75 | $740,138 | 23,575 | Yes | Form 4 |
| Atkinson Edward Morrow IIIEVP, Chief Technical Ops. Off. | Feb 17 | Feb 19 | S | 2,031 | $489.46 | Sale −$994,093 | 21,544 | Yes | Form 4 |
| Biller JonathanEVP and Chief Legal Officer | Feb 17 | Feb 19 | A | 4,135 | $0.00 | $0 | 20,973 | Yes | Form 4 |
| Biller JonathanEVP and Chief Legal Officer | Feb 17 | Feb 19 | F | 1,505 | $483.75 | $728,044 | 19,468 | Yes | Form 4 |
| Biller JonathanEVP and Chief Legal Officer | Feb 17 | Feb 19 | S | 2,476 | $489.46 | Sale −$1,211,903 | 16,992 | Yes | Form 4 |
| Bozic CarmenEVP and CMO | Feb 17 | Feb 19 | A | 5,375 | $0.00 | $0 | 43,428 | No | Form 4 |
| Bozic CarmenEVP and CMO | Feb 17 | Feb 19 | F | 1,912 | $483.75 | $924,930 | 41,516 | No | Form 4 |
| Bunnage Mark E.EVP, Chief Scientific Officer | Feb 17 | Feb 19 | A | 2,584 | $0.00 | $0 | 13,215 | Yes | Form 4 |
| Bunnage Mark E.EVP, Chief Scientific Officer | Feb 17 | Feb 19 | F | 1,110 | $483.75 | $536,963 | 12,105 | Yes | Form 4 |
| Bunnage Mark E.EVP, Chief Scientific Officer | Feb 17 | Feb 19 | S | 2,437 | $489.46 | Sale −$1,192,814 | 9,668 | Yes | Form 4 |
| Kewalramani ReshmaCEO & President | Feb 17 | Feb 19 | A | 16,326 | $0.00 | $0 | 149,813 | No | Form 4 |
| Kewalramani ReshmaCEO & President | Feb 17 | Feb 19 | F | 6,554 | $483.75 | $3,170,498 | 143,259 | No | Form 4 |
| Leiden Jeffrey MExecutive Chairman | Feb 17 | Feb 19 | A | 8,269 | $0.00 | $0 | 41,308 | No | Form 4 |
| McKechnie DuncanEVP, Chief Commercial Officer | Feb 17 | Feb 19 | A | 4,962 | $0.00 | $0 | 24,490 | No | Form 4 |
| McKechnie DuncanEVP, Chief Commercial Officer | Feb 17 | Feb 19 | F | 1,148 | $483.75 | $555,345 | 23,342 | No | Form 4 |
| Sachdev AmitEVP Chief Patient & Ext Af Off | Feb 17 | Feb 19 | A | 5,789 | $0.00 | $0 | 71,182 | No | Form 4 |
| Sachdev AmitEVP Chief Patient & Ext Af Off | Feb 17 | Feb 19 | F | 2,140 | $483.75 | $1,035,225 | 69,042 | No | Form 4 |
| Tatsis OuraniaEVP, Chief Reg. & Quality Off. | Feb 17 | Feb 19 | A | 5,789 | $0.00 | $0 | 51,921 | Yes | Form 4 |
| Tatsis OuraniaEVP, Chief Reg. & Quality Off. | Feb 17 | Feb 19 | F | 2,294 | $483.75 | $1,109,723 | 49,627 | Yes | Form 4 |
| Tatsis OuraniaEVP, Chief Reg. & Quality Off. | Feb 17 | Feb 19 | S | 609 | $489.46 | Sale −$298,081 | 49,018 | Yes | Form 4 |
| Wagner Charles F JrEVP, CO & FO | Feb 17 | Feb 19 | A | 7,365 | $0.00 | $0 | 51,080 | No | Form 4 |
| Wagner Charles F JrEVP, CO & FO | Feb 17 | Feb 19 | F | 2,294 | $483.75 | $1,109,723 | 48,786 | No | Form 4 |
| Ambrose KristenSVP & Chief Accounting Officer | Feb 13 | Feb 18 | F | 1,393 | $487.76 | $679,450 | 8,734 | No | Form 4 |
| Atkinson Edward Morrow IIIEVP, Chief Technical Ops. Off. | Feb 13 | Feb 18 | F | 1,903 | $487.76 | $928,207 | 20,143 | No | Form 4 |
| Bhatia Sangeeta N. | Feb 13 | Feb 18 | S | 266 | $500.00 | Sale −$133,000 | 4,299 | Yes | Form 4 |
| Biller JonathanEVP and Chief Legal Officer | Feb 13 | Feb 18 | F | 2,993 | $487.76 | $1,459,866 | 17,826 | Yes | Form 4 |
| Biller JonathanEVP and Chief Legal Officer | Feb 13 | Feb 18 | S | 988 | $499.00 | Sale −$493,012 | 16,838 | Yes | Form 4 |
| Bozic CarmenEVP and CMO | Feb 13 | Feb 18 | F | 3,804 | $487.76 | $1,855,439 | 38,053 | No | Form 4 |
| Bunnage Mark E.EVP, Chief Scientific Officer | Feb 13 | Feb 18 | F | 2,283 | $487.76 | $1,113,556 | 10,631 | No | Form 4 |
| Kewalramani ReshmaCEO & President | Feb 13 | Feb 18 | F | 13,041 | $487.76 | $6,360,878 | 133,487 | No | Form 4 |
| McKechnie DuncanEVP, Chief Commercial Officer | Feb 13 | Feb 18 | F | 2,283 | $487.76 | $1,113,556 | 19,528 | No | Form 4 |
| Sachdev AmitEVP Chief Patient & Ext Af Off | Feb 13 | Feb 18 | F | 3,548 | $487.76 | $1,730,572 | 65,393 | No | Form 4 |
| Tatsis OuraniaEVP, Chief Reg. & Quality Off. | Feb 13 | Feb 18 | F | 3,804 | $487.76 | $1,855,439 | 47,632 | Yes | Form 4 |
| Tatsis OuraniaEVP, Chief Reg. & Quality Off. | Feb 13 | Feb 18 | S | 1,500 | $499.99 | Sale −$749,985 | 46,132 | Yes | Form 4 |
| Wagner Charles F JrEVP, CO & FO | Feb 13 | Feb 18 | F | 4,565 | $487.76 | $2,226,624 | 43,715 | No | Form 4 |
| Ambrose KristenSVP & Chief Accounting Officer | Feb 11 | Feb 12 | S | 1,376 | $460.43 | Sale −$633,552 | 10,127 | Yes | Form 4 |
| Atkinson Edward Morrow IIIEVP, Chief Technical Ops. Off. | Feb 11 | Feb 12 | S | 1,751 | $460.43 | Sale −$806,213 | 22,046 | Yes | Form 4 |
| Biller JonathanEVP and Chief Legal Officer | Feb 11 | Feb 12 | S | 1,925 | $460.43 | Sale −$886,328 | 20,819 | Yes | Form 4 |
| Bunnage Mark E.EVP, Chief Scientific Officer | Feb 11 | Feb 12 | S | 2,021 | $460.43 | Sale −$930,529 | 12,914 | Yes | Form 4 |
| Tatsis OuraniaEVP, Chief Reg. & Quality Off. | Feb 11 | Feb 12 | S | 466 | $460.43 | Sale −$214,560 | 51,436 | Yes | Form 4 |
| Ambrose KristenSVP & Chief Accounting Officer | Feb 10 | Feb 12 | F | 592 | $468.41 | $277,299 | 11,503 | Yes | Form 4 |
| Atkinson Edward Morrow IIIEVP, Chief Technical Ops. Off. | Feb 10 | Feb 12 | F | 872 | $468.41 | $408,454 | 23,797 | Yes | Form 4 |
| Biller JonathanEVP and Chief Legal Officer | Feb 10 | Feb 12 | F | 1,630 | $468.41 | $763,508 | 22,744 | Yes | Form 4 |
| Bozic CarmenEVP and CMO | Feb 10 | Feb 12 | F | 2,145 | $468.41 | $1,004,739 | 41,857 | No | Form 4 |
| Bunnage Mark E.EVP, Chief Scientific Officer | Feb 10 | Feb 12 | F | 1,127 | $468.41 | $527,898 | 14,935 | Yes | Form 4 |
| Kewalramani ReshmaCEO & President | Feb 10 | Feb 12 | F | 8,297 | $468.41 | $3,886,398 | 146,528 | No | Form 4 |
| McKechnie DuncanEVP, Chief Commercial Officer | Feb 10 | Feb 12 | F | 1,127 | $468.41 | $527,898 | 21,811 | No | Form 4 |
| Sachdev AmitEVP Chief Patient & Ext Af Off | Feb 10 | Feb 12 | F | 2,057 | $468.41 | $963,519 | 68,941 | No | Form 4 |
| Tatsis OuraniaEVP, Chief Reg. & Quality Off. | Feb 10 | Feb 12 | F | 2,140 | $468.41 | $1,002,397 | 51,902 | Yes | Form 4 |
| Wagner Charles F JrEVP, CO & FO | Feb 10 | Feb 12 | F | 3,045 | $468.41 | $1,426,308 | 48,280 | No | Form 4 |
| Altshuler DavidEVP, Chief Scientific Officer | Jan 22 | Jan 26 | A | 7,866 | $0.00 | $0 | 31,149 | No | Form 4 |
| Altshuler DavidEVP, Chief Scientific Officer | Jan 22 | Jan 26 | A | 3,328 | $0.00 | $0 | 34,477 | No | Form 4 |
| Atkinson Edward Morrow IIIEVP, Chief Technical Ops. Off. | Jan 22 | Jan 26 | A | 3,934 | $0.00 | $0 | 20,786 | No | Form 4 |
| Atkinson Edward Morrow IIIEVP, Chief Technical Ops. Off. | Jan 22 | Jan 26 | A | 3,883 | $0.00 | $0 | 24,669 | No | Form 4 |
| Biller JonathanEVP and Chief Legal Officer | Jan 22 | Jan 26 | A | 6,294 | $0.00 | $0 | 21,600 | No | Form 4 |
| Biller JonathanEVP and Chief Legal Officer | Jan 22 | Jan 26 | A | 2,774 | $0.00 | $0 | 24,374 | No | Form 4 |
| Bozic CarmenEVP and CMO | Jan 22 | Jan 26 | A | 7,866 | $0.00 | $0 | 40,535 | No | Form 4 |
| Bozic CarmenEVP and CMO | Jan 22 | Jan 26 | A | 3,467 | $0.00 | $0 | 44,002 | No | Form 4 |
| Kewalramani ReshmaCEO & President | Jan 22 | Jan 26 | A | 26,972 | $0.00 | $0 | 142,940 | No | Form 4 |
| Kewalramani ReshmaCEO & President | Jan 22 | Jan 26 | A | 11,885 | $0.00 | $0 | 154,825 | No | Form 4 |
| Leiden Jeffrey MExecutive Chairman | Jan 22 | Jan 26 | A | 9,012 | $0.00 | $0 | 33,039 | No | Form 4 |
| McKechnie DuncanEVP, Chief Commercial Officer | Jan 22 | Jan 26 | A | 4,720 | $0.00 | $0 | 20,858 | No | Form 4 |
| McKechnie DuncanEVP, Chief Commercial Officer | Jan 22 | Jan 26 | A | 2,080 | $0.00 | $0 | 22,938 | No | Form 4 |
| Sachdev AmitEVP Chief Patient & Ext Af Off | Jan 22 | Jan 26 | A | 7,866 | $0.00 | $0 | 67,115 | No | Form 4 |
| Sachdev AmitEVP Chief Patient & Ext Af Off | Jan 22 | Jan 26 | A | 3,883 | $0.00 | $0 | 70,998 | No | Form 4 |
| Tatsis OuraniaEVP, Chief Reg. & Quality Off. | Jan 22 | Jan 26 | A | 7,866 | $0.00 | $0 | 50,159 | No | Form 4 |
| Tatsis OuraniaEVP, Chief Reg. & Quality Off. | Jan 22 | Jan 26 | A | 3,883 | $0.00 | $0 | 54,042 | No | Form 4 |
| Wagner Charles F JrEVP, CO & FO | Jan 22 | Jan 26 | A | 9,440 | $0.00 | $0 | 47,165 | No | Form 4 |
| Wagner Charles F JrEVP, CO & FO | Jan 22 | Jan 26 | A | 4,160 | $0.00 | $0 | 51,325 | No | Form 4 |
| Ambrose KristenSVP & Chief Accounting Officer | Jan 22 | Jan 26 | A | 2,950 | $0.00 | $0 | 10,795 | No | Form 4 |
| Ambrose KristenSVP & Chief Accounting Officer | Jan 22 | Jan 26 | A | 1,300 | $0.00 | $0 | 12,095 | No | Form 4 |
| Sachs Bruce I | Jan 15 | Jan 20 | A · derivative | 107.09 | $443.56 | $47,501 | 15,564.52 | No | Form 4 |
| Upadhyay Suketu | Jan 15 | Jan 20 | A · derivative | 80.32 | $443.56 | $35,627 | 2,718.65 | No | Form 4 |
| Tatsis OuraniaEVP, Chief Reg. & Quality Off. | Jan 7 | Jan 9 | S | 4,500 | $474.99 | Sale −$2,137,455 | 42,293 | Yes | Form 4 |
| Wagner Charles F JrEVP, CO & FO | Jan 6 | Jan 8 | M | 9,532 | $189.38 | $1,805,170 | 47,257 | Yes | Form 4 |
| Wagner Charles F JrEVP, CO & FO | Jan 6 | Jan 8 | S | 9,532 | $461.00 | Sale −$4,394,252 | 37,725 | Yes | Form 4 |
| Wagner Charles F JrEVP, CO & FO | Jan 6 | Jan 8 | M · derivative | 9,532 | $189.38 | $1,805,170 | not reported | Yes | Form 4 |
| Leiden Jeffrey MExecutive Chairman | Dec 4, 2025 | Dec 5, 2025 | M | 1 | $91.05 | $91 | 24,027 | Yes | Form 4 |
| Leiden Jeffrey MExecutive Chairman | Dec 4, 2025 | Dec 5, 2025 | M · derivative | 1 | $91.05 | $91 | not reported | Yes | Form 4 |
| Biller JonathanEVP and Chief Legal Officer | Dec 3, 2025 | Dec 5, 2025 | S | 347 | $449.00 | Sale −$155,803 | 15,306 | Yes | Form 4 |
| Leiden Jeffrey MExecutive Chairman | Dec 3, 2025 | Dec 5, 2025 | M | 63,781 | $86.52 | $5,518,332 | 87,807 | Yes | Form 4 |
| Leiden Jeffrey MExecutive Chairman | Dec 3, 2025 | Dec 5, 2025 | S | 4,469 | $440.40 | Sale −$1,968,148 | 83,338 | Yes | Form 4 |
| Leiden Jeffrey MExecutive Chairman | Dec 3, 2025 | Dec 5, 2025 | S | 1,320 | $441.26 | Sale −$582,463 | 82,018 | Yes | Form 4 |
| Leiden Jeffrey MExecutive Chairman | Dec 3, 2025 | Dec 5, 2025 | S | 2,469 | $443.21 | Sale −$1,094,285 | 79,549 | Yes | Form 4 |
| Leiden Jeffrey MExecutive Chairman | Dec 3, 2025 | Dec 5, 2025 | S | 4,352 | $444.36 | Sale −$1,933,855 | 75,197 | Yes | Form 4 |
| Leiden Jeffrey MExecutive Chairman | Dec 3, 2025 | Dec 5, 2025 | S | 7,899 | $445.56 | Sale −$3,519,478 | 67,298 | Yes | Form 4 |
| Leiden Jeffrey MExecutive Chairman | Dec 3, 2025 | Dec 5, 2025 | S | 1,152 | $447.05 | Sale −$515,002 | 66,146 | Yes | Form 4 |
| Leiden Jeffrey MExecutive Chairman | Dec 3, 2025 | Dec 5, 2025 | S | 2,320 | $448.78 | Sale −$1,041,170 | 63,826 | Yes | Form 4 |
| Leiden Jeffrey MExecutive Chairman | Dec 3, 2025 | Dec 5, 2025 | S | 5,880 | $449.84 | Sale −$2,645,059 | 57,946 | Yes | Form 4 |
| Leiden Jeffrey MExecutive Chairman | Dec 3, 2025 | Dec 5, 2025 | S | 5,809 | $451.20 | Sale −$2,621,021 | 52,137 | Yes | Form 4 |
| Leiden Jeffrey MExecutive Chairman | Dec 3, 2025 | Dec 5, 2025 | S | 15,681 | $452.20 | Sale −$7,090,948 | 36,456 | Yes | Form 4 |
| Leiden Jeffrey MExecutive Chairman | Dec 3, 2025 | Dec 5, 2025 | S | 10,360 | $453.34 | Sale −$4,696,602 | 26,096 | Yes | Form 4 |
| Leiden Jeffrey MExecutive Chairman | Dec 3, 2025 | Dec 5, 2025 | S | 2,070 | $455.22 | Sale −$942,305 | 24,026 | Yes | Form 4 |
| Leiden Jeffrey MExecutive Chairman | Dec 3, 2025 | Dec 5, 2025 | M · derivative | 63,781 | $86.52 | $5,518,332 | not reported | Yes | Form 4 |
| Tatsis OuraniaEVP, Chief Reg. & Quality Off. | Dec 3, 2025 | Dec 5, 2025 | S | 4,500 | $449.99 | Sale −$2,024,955 | 46,793 | Yes | Form 4 |
| Wagner Charles F JrEVP, CO & FO | Dec 3, 2025 | Dec 5, 2025 | S | 7,000 | $451.00 | Sale −$3,157,000 | 44,725 | Yes | Form 4 |
| Wagner Charles F JrEVP, CO & FO | Dec 3, 2025 | Dec 5, 2025 | S | 7,000 | $461.00 | Sale −$3,227,000 | 37,725 | Yes | Form 4 |
| Carney Lloyd | Nov 19, 2025 | Nov 20, 2025 | G | 800 | $0.00 | $0 | 6,315 | No | Form 4 |
| Atkinson Edward Morrow IIIEVP, Chief Technical Ops. Off. | Nov 17, 2025 | Nov 19, 2025 | S | 2,500 | $434.58 | Sale −$1,086,450 | 16,852 | Yes | Form 4 |
| Leiden Jeffrey MExecutive Chairman | Nov 14, 2025 | Nov 17, 2025 | M | 13,835 | $91.05 | $1,259,677 | 37,861 | Yes | Form 4 |
| Leiden Jeffrey MExecutive Chairman | Nov 14, 2025 | Nov 17, 2025 | M | 39,769 | $86.52 | $3,440,814 | 77,630 | Yes | Form 4 |
| Leiden Jeffrey MExecutive Chairman | Nov 14, 2025 | Nov 17, 2025 | S | 32,234 | $440.30 | Sale −$14,192,630 | 45,396 | Yes | Form 4 |
| Leiden Jeffrey MExecutive Chairman | Nov 14, 2025 | Nov 17, 2025 | S | 21,330 | $441.35 | Sale −$9,413,996 | 24,066 | Yes | Form 4 |
| Leiden Jeffrey MExecutive Chairman | Nov 14, 2025 | Nov 17, 2025 | S | 40 | $442.00 | Sale −$17,680 | 24,026 | Yes | Form 4 |
| Leiden Jeffrey MExecutive Chairman | Nov 14, 2025 | Nov 17, 2025 | M · derivative | 13,835 | $91.05 | $1,259,677 | 1 | Yes | Form 4 |
| Leiden Jeffrey MExecutive Chairman | Nov 14, 2025 | Nov 17, 2025 | M · derivative | 39,769 | $86.52 | $3,440,814 | 63,781 | Yes | Form 4 |
| Leiden Jeffrey MExecutive Chairman | Nov 13, 2025 | Nov 17, 2025 | M | 19,688 | $91.05 | $1,792,592 | 43,714 | Yes | Form 4 |
| Leiden Jeffrey MExecutive Chairman | Nov 13, 2025 | Nov 17, 2025 | S | 18,528 | $440.22 | Sale −$8,156,396 | 25,186 | Yes | Form 4 |
| Leiden Jeffrey MExecutive Chairman | Nov 13, 2025 | Nov 17, 2025 | S | 1,160 | $441.05 | Sale −$511,618 | 24,026 | Yes | Form 4 |
| Leiden Jeffrey MExecutive Chairman | Nov 13, 2025 | Nov 17, 2025 | M · derivative | 19,688 | $91.05 | $1,792,592 | 13,836 | Yes | Form 4 |
| Sachs Bruce I | Oct 15, 2025 | Oct 17, 2025 | A · derivative | 115.77 | $410.31 | $47,502 | 15,457.43 | No | Form 4 |
| Upadhyay Suketu | Oct 15, 2025 | Oct 17, 2025 | A · derivative | 86.83 | $410.31 | $35,627 | 2,638.33 | No | Form 4 |
| Biller JonathanEVP and Chief Legal Officer | Oct 2, 2025 | Oct 3, 2025 | S | 694 | $404.21 | Sale −$280,522 | 15,653 | Yes | Form 4 |
| Biller JonathanEVP and Chief Legal Officer | Oct 1, 2025 | Oct 3, 2025 | F | 1,259 | $400.00 | $503,600 | 16,347 | Yes | Form 4 |
| Bhatia Sangeeta N. | Aug 27, 2025 | Aug 29, 2025 | S | 266 | $386.69 | Sale −$102,860 | 4,565 | Yes | Form 4 |
| Sachs Bruce I | Aug 6, 2025 | Aug 7, 2025 | P | 1,634 | $389.36 | Purchase +$636,214 | 41,634 | No | Form 4 |
| Sachs Bruce I | Aug 6, 2025 | Aug 7, 2025 | P | 3,366 | $389.84 | Purchase +$1,312,201 | 45,000 | No | Form 4 |
| Kewalramani ReshmaCEO & President | Aug 6, 2025 | Aug 7, 2025 | P | 4,290 | $389.08 | Purchase +$1,669,153 | 110,258 | No | Form 4 |
| Kewalramani ReshmaCEO & President | Aug 6, 2025 | Aug 7, 2025 | P | 5,710 | $389.95 | Purchase +$2,226,615 | 115,968 | No | Form 4 |
| Sachs Bruce I | Jul 15, 2025 | Jul 17, 2025 | A · derivative | 101.21 | $469.34 | $47,502 | 15,341.67 | No | Form 4 |
| Upadhyay Suketu | Jul 15, 2025 | Jul 17, 2025 | A · derivative | 75.9 | $469.34 | $35,623 | 2,551.51 | No | Form 4 |
| Arbuckle Stuart AEVP, COO | Jul 1, 2025 | Jul 2, 2025 | F | 37,243 | $450.23 | $16,767,916 | 63,368 | No | Form 4 |
| Altshuler DavidEVP, Chief Scientific Officer | May 15, 2025 | May 19, 2025 | S | 52 | $424.69 | Sale −$22,084 | 23,281 | Yes | Form 4 |
| Arbuckle Stuart AEVP, COO | May 13, 2025 | May 15, 2025 | A | 37,622 | $0.00 | $0 | 100,611 | No | Form 4 |
| Bhatia Sangeeta N. | May 2, 2025 | May 5, 2025 | S | 400 | $505.86 | Sale −$202,344 | 4,831 | Yes | Form 4 |
| Bhatia Sangeeta N. | May 1, 2025 | May 5, 2025 | A | 796 | $0.00 | $0 | 5,231 | Yes | Form 4 |
| Carney Lloyd | May 1, 2025 | May 5, 2025 | A | 796 | $0.00 | $0 | 7,115 | No | Form 4 |
| Garber Alan M | May 1, 2025 | May 5, 2025 | A | 398 | $0.00 | $0 | 6,872 | No | Form 4 |
| Garber Alan M | May 1, 2025 | May 5, 2025 | A · derivative | 1,199 | $502.97 | $603,061 | 1,199 | No | Form 4 |
| Lagarde Michel | May 1, 2025 | May 5, 2025 | A · derivative | 2,398 | $502.97 | $1,206,122 | 2,398 | No | Form 4 |
| Mckenzie Diana | May 1, 2025 | May 5, 2025 | A | 796 | $0.00 | $0 | 3,232 | No | Form 4 |
| Mckenzie Diana | May 1, 2025 | May 5, 2025 | D | 1,001 | not reported | not reported | 2,231 | No | Form 4 |
| Mckenzie Diana | May 1, 2025 | May 5, 2025 | A · derivative | 1,001 | not reported | not reported | 6,991.48 | No | Form 4 |
| Sachs Bruce I | May 1, 2025 | May 5, 2025 | A · derivative | 2,398 | $502.97 | $1,206,122 | 2,398 | No | Form 4 |
| Schneider Jennifer | May 1, 2025 | May 5, 2025 | A | 796 | $0.00 | $0 | 1,718 | No | Form 4 |
| Thornberry Nancy | May 1, 2025 | May 5, 2025 | A | 398 | $0.00 | $0 | 2,035 | No | Form 4 |
| Thornberry Nancy | May 1, 2025 | May 5, 2025 | A · derivative | 1,199 | $502.97 | $603,061 | 1,199 | No | Form 4 |
| Upadhyay Suketu | May 1, 2025 | May 5, 2025 | A | 796 | $0.00 | $0 | 3,355 | No | Form 4 |
| Upadhyay Suketu | May 1, 2025 | May 5, 2025 | D | 1,001 | not reported | not reported | 2,354 | No | Form 4 |
| Upadhyay Suketu | May 1, 2025 | May 5, 2025 | A · derivative | 1,001 | not reported | not reported | 2,475.6 | No | Form 4 |
| Sachs Bruce I | Apr 15, 2025 | Apr 17, 2025 | A · derivative | 95.48 | $497.51 | $47,502 | 15,240.46 | No | Form 4 |
| Upadhyay Suketu | Apr 15, 2025 | Apr 17, 2025 | A · derivative | 71.61 | $497.51 | $35,627 | 1,474.6 | No | Form 4 |
| Altshuler DavidEVP, Chief Scientific Officer | Mar 13, 2025 | Mar 17, 2025 | S | 3,231 | $510.00 | Sale −$1,647,810 | 23,281 | Yes | Form 4 |
| Altshuler DavidEVP, Chief Scientific Officer | Mar 10, 2025 | Mar 12, 2025 | S | 3,231 | $500.00 | Sale −$1,615,500 | 26,512 | Yes | Form 4 |
| Tatsis OuraniaEVP, Chief Reg. & Quality Off. | Mar 10, 2025 | Mar 12, 2025 | S | 3,242 | $499.99 | Sale −$1,620,968 | 51,239 | Yes | Form 4 |
| Wagner Charles F JrEVP & Chief Financial Officer | Mar 10, 2025 | Mar 12, 2025 | S | 3,298 | $500.00 | Sale −$1,649,000 | 51,671 | Yes | Form 4 |
| Tatsis OuraniaEVP, Chief Reg. & Quality Off. | Mar 4, 2025 | Mar 6, 2025 | S | 4,058 | $485.49 | Sale −$1,970,118 | 54,481 | Yes | Form 4 |
| Altshuler DavidEVP, Chief Scientific Officer | Mar 3, 2025 | Mar 5, 2025 | S | 3,231 | $490.00 | Sale −$1,583,190 | 29,743 | Yes | Form 4 |
| Altshuler DavidEVP, Chief Scientific Officer | Feb 27, 2025 | Feb 28, 2025 | S | 1,272 | $480.00 | Sale −$610,560 | 32,974 | Yes | Form 4 |
| Atkinson Edward Morrow IIIEVP, Chief Technical Ops. Off. | Feb 27, 2025 | Feb 28, 2025 | S | 2,650 | $475.34 | Sale −$1,259,651 | 19,352 | Yes | Form 4 |
| Tatsis OuraniaEVP, Chief Reg. & Quality Off. | Feb 27, 2025 | Feb 28, 2025 | S | 530 | $475.34 | Sale −$251,930 | 58,539 | Yes | Form 4 |
| Altshuler DavidEVP, Chief Scientific Officer | Feb 26, 2025 | Feb 28, 2025 | F | 5,954 | $479.61 | $2,855,598 | 34,246 | Yes | Form 4 |
| Ambrose KristenSVP & Chief Accounting Officer | Feb 26, 2025 | Feb 28, 2025 | F | 1,241 | $479.61 | $595,196 | 7,845 | No | Form 4 |
| Arbuckle Stuart AEVP, COO | Feb 26, 2025 | Feb 28, 2025 | F | 7,071 | $479.61 | $3,391,322 | 62,935 | No | Form 4 |
| Atkinson Edward Morrow IIIEVP, Chief Technical Ops. Off. | Feb 26, 2025 | Feb 28, 2025 | F | 2,482 | $479.61 | $1,190,392 | 22,002 | Yes | Form 4 |
| Bozic CarmenEVP and CMO | Feb 26, 2025 | Feb 28, 2025 | F | 4,962 | $479.61 | $2,379,825 | 32,669 | No | Form 4 |
| Kewalramani ReshmaCEO & President | Feb 26, 2025 | Feb 28, 2025 | F | 14,079 | $479.61 | $6,752,429 | 105,915 | No | Form 4 |
| Sachdev AmitEVP Chief Patient & Ext Af Off | Feb 26, 2025 | Feb 28, 2025 | F | 3,703 | $479.61 | $1,775,996 | 68,490 | No | Form 4 |
| Tatsis OuraniaEVP, Chief Reg. & Quality Off. | Feb 26, 2025 | Feb 28, 2025 | F | 4,962 | $479.61 | $2,379,825 | 59,069 | Yes | Form 4 |
| Wagner Charles F JrEVP & Chief Financial Officer | Feb 26, 2025 | Feb 28, 2025 | F | 4,962 | $479.61 | $2,379,825 | 54,969 | No | Form 4 |
| Altshuler DavidEVP, Chief Scientific Officer | Feb 25, 2025 | Feb 26, 2025 | S | 848 | $480.95 | Sale −$407,846 | 40,200 | Yes | Form 4 |
| Ambrose KristenSVP & Chief Accounting Officer | Feb 25, 2025 | Feb 26, 2025 | S | 884 | $480.95 | Sale −$425,160 | 9,086 | Yes | Form 4 |
| Atkinson Edward Morrow IIIEVP, Chief Technical Ops. Off. | Feb 25, 2025 | Feb 26, 2025 | S | 1,767 | $480.95 | Sale −$849,839 | 24,484 | Yes | Form 4 |
| Tatsis OuraniaEVP, Chief Reg. & Quality Off. | Feb 25, 2025 | Feb 26, 2025 | S | 354 | $480.95 | Sale −$170,256 | 64,031 | Yes | Form 4 |
| Altshuler DavidEVP, Chief Scientific Officer | Feb 24, 2025 | Feb 26, 2025 | F | 3,971 | $483.28 | $1,919,105 | 41,048 | Yes | Form 4 |
| Ambrose KristenSVP & Chief Accounting Officer | Feb 24, 2025 | Feb 26, 2025 | F | 828 | $483.28 | $400,156 | 9,970 | Yes | Form 4 |
| Arbuckle Stuart AEVP, COO | Feb 24, 2025 | Feb 26, 2025 | F | 4,716 | $483.28 | $2,279,148 | 70,006 | No | Form 4 |
| Atkinson Edward Morrow IIIEVP, Chief Technical Ops. Off. | Feb 24, 2025 | Feb 26, 2025 | F | 1,656 | $483.28 | $800,312 | 26,251 | Yes | Form 4 |
| Bozic CarmenEVP and CMO | Feb 24, 2025 | Feb 26, 2025 | F | 3,310 | $483.28 | $1,599,657 | 37,631 | No | Form 4 |
| Kewalramani ReshmaCEO & President | Feb 24, 2025 | Feb 26, 2025 | F | 9,386 | $483.28 | $4,536,066 | 119,994 | No | Form 4 |
| Sachdev AmitEVP Chief Patient & Ext Af Off | Feb 24, 2025 | Feb 26, 2025 | F | 2,470 | $483.28 | $1,193,702 | 72,193 | No | Form 4 |
| Tatsis OuraniaEVP, Chief Reg. & Quality Off. | Feb 24, 2025 | Feb 26, 2025 | F | 3,310 | $483.28 | $1,599,657 | 64,385 | Yes | Form 4 |
| Wagner Charles F JrEVP & Chief Financial Officer | Feb 24, 2025 | Feb 26, 2025 | F | 3,310 | $483.28 | $1,599,657 | 59,931 | No | Form 4 |
| Altshuler DavidEVP, Chief Scientific Officer | Feb 20, 2025 | Feb 24, 2025 | S | 1,111 | $480.00 | Sale −$533,280 | 45,019 | Yes | Form 4 |
| Ambrose KristenSVP & Chief Accounting Officer | Feb 18, 2025 | Feb 19, 2025 | S | 671 | $455.06 | Sale −$305,345 | 10,798 | Yes | Form 4 |
| Biller JonathanEVP and Chief Legal Officer | Feb 18, 2025 | Feb 19, 2025 | S | 1,657 | $455.06 | Sale −$754,034 | 17,606 | Yes | Form 4 |
| Tatsis OuraniaEVP, Chief Reg. & Quality Off. | Feb 18, 2025 | Feb 19, 2025 | S | 244 | $455.06 | Sale −$111,035 | 67,695 | Yes | Form 4 |
| Altshuler DavidEVP, Chief Scientific Officer | Feb 14, 2025 | Feb 19, 2025 | F | 2,293 | $463.46 | $1,062,714 | 46,130 | No | Form 4 |
| Ambrose KristenSVP & Chief Accounting Officer | Feb 14, 2025 | Feb 19, 2025 | F | 564 | $463.46 | $261,391 | 11,469 | Yes | Form 4 |
| Arbuckle Stuart AEVP, COO | Feb 14, 2025 | Feb 19, 2025 | F | 2,724 | $463.46 | $1,262,465 | 74,722 | No | Form 4 |
| Atkinson Edward Morrow IIIEVP, Chief Technical Ops. Off. | Feb 14, 2025 | Feb 19, 2025 | F | 1,529 | $463.46 | $708,630 | 27,907 | No | Form 4 |
| Biller JonathanEVP and Chief Legal Officer | Feb 14, 2025 | Feb 19, 2025 | F | 1,504 | $463.46 | $697,044 | 19,263 | Yes | Form 4 |
| Bozic CarmenEVP and CMO | Feb 14, 2025 | Feb 19, 2025 | F | 1,912 | $463.46 | $886,136 | 40,941 | No | Form 4 |
| Kewalramani ReshmaCEO & President | Feb 14, 2025 | Feb 19, 2025 | F | 6,553 | $463.46 | $3,037,053 | 129,380 | No | Form 4 |
| Leiden Jeffrey MExecutive Chairman | Feb 14, 2025 | Feb 19, 2025 | F | 6,066 | $463.46 | $2,811,348 | 24,026 | No | Form 4 |
| Sachdev AmitEVP Chief Patient & Ext Af Off | Feb 14, 2025 | Feb 19, 2025 | F | 2,139 | $463.46 | $991,341 | 74,663 | No | Form 4 |
| Tatsis OuraniaEVP, Chief Reg. & Quality Off. | Feb 14, 2025 | Feb 19, 2025 | F | 2,293 | $463.46 | $1,062,714 | 67,939 | Yes | Form 4 |
| Wagner Charles F JrEVP & Chief Financial Officer | Feb 14, 2025 | Feb 19, 2025 | F | 2,293 | $463.46 | $1,062,714 | 63,241 | No | Form 4 |
| Leiden Jeffrey MExecutive Chairman | Feb 13, 2025 | Feb 14, 2025 | F | 2,525 | $450.83 | $1,138,346 | 30,092 | No | Form 4 |
| Altshuler DavidEVP, Chief Scientific Officer | Feb 12, 2025 | Feb 14, 2025 | A | 5,324 | $0.00 | $0 | 48,423 | No | Form 4 |
| Ambrose KristenSVP & Chief Accounting Officer | Feb 12, 2025 | Feb 14, 2025 | A | 2,080 | $0.00 | $0 | 12,033 | No | Form 4 |
| Arbuckle Stuart AEVP, COO | Feb 12, 2025 | Feb 14, 2025 | A | 7,903 | $0.00 | $0 | 77,446 | No | Form 4 |
| Atkinson Edward Morrow IIIEVP, Chief Technical Ops. Off. | Feb 12, 2025 | Feb 14, 2025 | A | 6,211 | $0.00 | $0 | 29,436 | No | Form 4 |
| Biller JonathanEVP and Chief Legal Officer | Feb 12, 2025 | Feb 14, 2025 | A | 4,437 | $0.00 | $0 | 20,767 | No | Form 4 |
| Bozic CarmenEVP and CMO | Feb 12, 2025 | Feb 14, 2025 | A | 5,546 | $0.00 | $0 | 42,853 | No | Form 4 |
| Kewalramani ReshmaCEO & President | Feb 12, 2025 | Feb 14, 2025 | A | 19,015 | $0.00 | $0 | 135,933 | No | Form 4 |
| Sachdev AmitEVP Chief Patient & Ext Af Off | Feb 12, 2025 | Feb 14, 2025 | A | 6,211 | $0.00 | $0 | 76,802 | No | Form 4 |
| Leiden Jeffrey MExecutive Chairman | Feb 12, 2025 | Feb 14, 2025 | A | 7,209 | $0.00 | $0 | 32,617 | No | Form 4 |
| Tatsis OuraniaEVP, Chief Reg. & Quality Off. | Feb 12, 2025 | Feb 14, 2025 | A | 6,211 | $0.00 | $0 | 70,232 | No | Form 4 |
| Wagner Charles F JrEVP & Chief Financial Officer | Feb 12, 2025 | Feb 14, 2025 | A | 6,655 | $0.00 | $0 | 65,534 | No | Form 4 |
| Ambrose KristenSVP & Chief Accounting Officer | Feb 11, 2025 | Feb 12, 2025 | S | 1,376 | $459.83 | Sale −$632,726 | 9,953 | Yes | Form 4 |
| Atkinson Edward Morrow IIIEVP, Chief Technical Ops. Off. | Feb 11, 2025 | Feb 12, 2025 | S | 1,747 | $459.83 | Sale −$803,323 | 23,225 | Yes | Form 4 |
| Biller JonathanEVP and Chief Legal Officer | Feb 11, 2025 | Feb 12, 2025 | S | 3,433 | $459.87 | Sale −$1,578,734 | 16,330 | Yes | Form 4 |
| Tatsis OuraniaEVP, Chief Reg. & Quality Off. | Feb 11, 2025 | Feb 12, 2025 | S | 310 | $459.83 | Sale −$142,547 | 64,021 | Yes | Form 4 |
| Altshuler DavidEVP, Chief Scientific Officer | Feb 10, 2025 | Feb 12, 2025 | F | 2,142 | $467.98 | $1,002,413 | 43,099 | No | Form 4 |
| Ambrose KristenSVP & Chief Accounting Officer | Feb 10, 2025 | Feb 12, 2025 | F | 591 | $467.98 | $276,576 | 11,329 | Yes | Form 4 |
| Arbuckle Stuart AEVP, COO | Feb 10, 2025 | Feb 12, 2025 | F | 3,220 | $467.98 | $1,506,896 | 69,543 | No | Form 4 |
| Atkinson Edward Morrow IIIEVP, Chief Technical Ops. Off. | Feb 10, 2025 | Feb 12, 2025 | F | 876 | $467.98 | $409,950 | 24,972 | Yes | Form 4 |
| Biller JonathanEVP and Chief Legal Officer | Feb 10, 2025 | Feb 12, 2025 | F | 1,632 | $467.98 | $763,743 | 19,763 | Yes | Form 4 |
| Bozic CarmenEVP and CMO | Feb 10, 2025 | Feb 12, 2025 | F | 2,142 | $467.98 | $1,002,413 | 37,307 | No | Form 4 |
| Kewalramani ReshmaCEO & President | Feb 10, 2025 | Feb 12, 2025 | F | 8,300 | $467.98 | $3,884,234 | 116,918 | No | Form 4 |
| Sachdev AmitEVP Chief Patient & Ext Af Off | Feb 10, 2025 | Feb 12, 2025 | F | 2,056 | $467.98 | $962,167 | 70,591 | No | Form 4 |
| Tatsis OuraniaEVP, Chief Reg. & Quality Off. | Feb 10, 2025 | Feb 12, 2025 | F | 2,143 | $467.98 | $1,002,881 | 64,331 | Yes | Form 4 |
| Wagner Charles F JrEVP & Chief Financial Officer | Feb 10, 2025 | Feb 12, 2025 | F | 2,649 | $467.98 | $1,239,679 | 58,879 | No | Form 4 |
| Altshuler DavidEVP, Chief Scientific Officer | Feb 4, 2025 | Feb 6, 2025 | A | 12,314 | $0.00 | $0 | 38,127 | No | Form 4 |
| Altshuler DavidEVP, Chief Scientific Officer | Feb 4, 2025 | Feb 6, 2025 | A | 7,114 | $0.00 | $0 | 45,241 | No | Form 4 |
| Ambrose KristenSVP & Chief Accounting Officer | Feb 4, 2025 | Feb 6, 2025 | A | 2,566 | $0.00 | $0 | 10,066 | No | Form 4 |
| Ambrose KristenSVP & Chief Accounting Officer | Feb 4, 2025 | Feb 6, 2025 | A | 1,854 | $0.00 | $0 | 11,920 | No | Form 4 |
| Arbuckle Stuart AEVP, COO | Feb 4, 2025 | Feb 6, 2025 | A | 14,624 | $0.00 | $0 | 64,315 | No | Form 4 |
| Arbuckle Stuart AEVP, COO | Feb 4, 2025 | Feb 6, 2025 | A | 8,448 | $0.00 | $0 | 72,763 | No | Form 4 |
| Atkinson Edward Morrow IIIEVP, Chief Technical Ops. Off. | Feb 4, 2025 | Feb 6, 2025 | A | 5,132 | $0.00 | $0 | 21,104 | No | Form 4 |
| Atkinson Edward Morrow IIIEVP, Chief Technical Ops. Off. | Feb 4, 2025 | Feb 6, 2025 | A | 4,744 | $0.00 | $0 | 25,848 | No | Form 4 |
| Biller JonathanEVP and Chief Legal Officer | Feb 4, 2025 | Feb 6, 2025 | A | 4,744 | $0.00 | $0 | 21,395 | No | Form 4 |
| Bozic CarmenEVP and CMO | Feb 4, 2025 | Feb 6, 2025 | A | 10,262 | $0.00 | $0 | 33,521 | No | Form 4 |
| Bozic CarmenEVP and CMO | Feb 4, 2025 | Feb 6, 2025 | A | 5,928 | $0.00 | $0 | 39,449 | No | Form 4 |
| Kewalramani ReshmaCEO & President | Feb 4, 2025 | Feb 6, 2025 | A | 29,118 | $0.00 | $0 | 104,890 | No | Form 4 |
| Kewalramani ReshmaCEO & President | Feb 4, 2025 | Feb 6, 2025 | A | 20,328 | $0.00 | $0 | 125,218 | No | Form 4 |
| Leiden Jeffrey MExecutive Chairman | Feb 4, 2025 | Feb 6, 2025 | A | 15,414 | $0.00 | $0 | 25,408 | No | Form 4 |
| Sachdev AmitEVP Chief Patient & Ext Af Off | Feb 4, 2025 | Feb 6, 2025 | A | 8,210 | $0.00 | $0 | 65,533 | No | Form 4 |
| Sachdev AmitEVP Chief Patient & Ext Af Off | Feb 4, 2025 | Feb 6, 2025 | A | 7,114 | $0.00 | $0 | 72,647 | No | Form 4 |
| Tatsis OuraniaEVP, Chief Reg. & Quality Off. | Feb 4, 2025 | Feb 6, 2025 | A | 10,262 | $0.00 | $0 | 59,360 | No | Form 4 |
| Tatsis OuraniaEVP, Chief Reg. & Quality Off. | Feb 4, 2025 | Feb 6, 2025 | A | 7,114 | $0.00 | $0 | 66,474 | No | Form 4 |
| Wagner Charles F JrEVP & Chief Financial Officer | Feb 4, 2025 | Feb 6, 2025 | A | 10,262 | $0.00 | $0 | 54,414 | No | Form 4 |
| Wagner Charles F JrEVP & Chief Financial Officer | Feb 4, 2025 | Feb 6, 2025 | A | 7,114 | $0.00 | $0 | 61,528 | No | Form 4 |
| Sachs Bruce I | Jan 15, 2025 | Jan 17, 2025 | A · derivative | 111.65 | $420.31 | $46,928 | 15,144.99 | No | Form 4 |
| Altshuler DavidEVP, Chief Scientific Officer | Nov 15, 2024 | Nov 19, 2024 | S | 15 | $478.56 | Sale −$7,178 | 25,813 | Yes | Form 4 |
| Wagner Charles F JrEVP & Chief Financial Officer | Nov 11, 2024 | Nov 13, 2024 | S | 3,000 | $518.27 | Sale −$1,554,810 | 44,137 | Yes | Form 4 |
| Kewalramani ReshmaCEO & President | Nov 8, 2024 | Nov 12, 2024 | S | 15,198 | $515.00 | Sale −$7,826,970 | 75,772 | Yes | Form 4 |
| Sachs Bruce I | Oct 15, 2024 | Oct 17, 2024 | A · derivative | 90.32 | $484.39 | $43,750 | 15,033.33 | No | Form 4 |
| Biller JonathanEVP and Chief Legal Officer | Oct 2, 2024 | Oct 3, 2024 | S | 999 | $461.66 | Sale −$461,198 | 16,651 | Yes | Form 4 |
| Biller JonathanEVP and Chief Legal Officer | Oct 1, 2024 | Oct 3, 2024 | F | 630 | $466.84 | $294,109 | 17,650 | Yes | Form 4 |
| Bhatia Sangeeta N. | Aug 30, 2024 | Sep 4, 2024 | M | 646 | $152.74 | $98,670 | 5,081 | Yes | Form 4 |
| Bhatia Sangeeta N. | Aug 30, 2024 | Sep 4, 2024 | S | 646 | $500.00 | Sale −$323,000 | 4,435 | Yes | Form 4 |
| Bhatia Sangeeta N. | Aug 30, 2024 | Sep 4, 2024 | M · derivative | 646 | $152.74 | $98,670 | not reported | Yes | Form 4 |
| Leiden Jeffrey MExecutive Chairman | Aug 30, 2024 | Sep 4, 2024 | S | 3,784 | $499.00 | Sale −$1,888,216 | 9,994 | Yes | Form 4 |
| Bhatia Sangeeta N. | Aug 8, 2024 | Aug 12, 2024 | M | 1,292 | $152.74 | $197,340 | 5,727 | Yes | Form 4 |
| Bhatia Sangeeta N. | Aug 8, 2024 | Aug 12, 2024 | S | 1,292 | $466.29 | Sale −$602,447 | 4,435 | Yes | Form 4 |
| Bhatia Sangeeta N. | Aug 8, 2024 | Aug 12, 2024 | M · derivative | 1,292 | $152.74 | $197,340 | 646 | Yes | Form 4 |
| Bozic CarmenEVP and CMO | Aug 7, 2024 | Aug 8, 2024 | S | 2,280 | $476.75 | Sale −$1,086,990 | 23,259 | Yes | Form 4 |
| Sachs Bruce I | Aug 1, 2024 | Aug 2, 2024 | M | 5,295 | $125.71 | $665,634 | 45,295 | Yes | Form 4 |
| Sachs Bruce I | Aug 1, 2024 | Aug 2, 2024 | S | 5,295 | $508.00 | Sale −$2,689,860 | 40,000 | Yes | Form 4 |
| Sachs Bruce I | Aug 1, 2024 | Aug 2, 2024 | M · derivative | 5,295 | $125.71 | $665,634 | not reported | Yes | Form 4 |
| Kewalramani ReshmaCEO & President | Jul 30, 2024 | Aug 1, 2024 | S | 15,202 | $505.00 | Sale −$7,677,010 | 90,970 | Yes | Form 4 |
| Bozic CarmenEVP and CMO | Jul 24, 2024 | Jul 25, 2024 | S | 2,280 | $488.46 | Sale −$1,113,689 | 25,539 | Yes | Form 4 |
| Kewalramani ReshmaCEO & President | Jul 22, 2024 | Jul 24, 2024 | S | 15,202 | $497.00 | Sale −$7,555,394 | 106,172 | Yes | Form 4 |
| Sachs Bruce I | Jul 15, 2024 | Jul 17, 2024 | A · derivative | 89.26 | $490.12 | $43,748 | 14,943.01 | No | Form 4 |
| Bozic CarmenEVP and CMO | Jul 10, 2024 | Jul 12, 2024 | S | 2,280 | $487.34 | Sale −$1,111,135 | 27,819 | Yes | Form 4 |
| Bozic CarmenEVP and CMO | Jun 26, 2024 | Jun 28, 2024 | S | 2,280 | $471.72 | Sale −$1,075,522 | 30,099 | Yes | Form 4 |
| Atkinson Edward Morrow IIIEVP, Chief Technical Ops. Off. | Jun 12, 2024 | Jun 13, 2024 | S | 7,288 | $478.00 | Sale −$3,483,664 | 15,972 | Yes | Form 4 |
| Bozic CarmenEVP and CMO | Jun 12, 2024 | Jun 13, 2024 | S | 2,280 | $478.00 | Sale −$1,089,840 | 32,379 | Yes | Form 4 |
| Atkinson Edward Morrow IIIEVP, Chief Technical Ops. Off. | Jun 11, 2024 | Jun 13, 2024 | F | 6,824 | $481.96 | $3,288,895 | 23,260 | Yes | Form 4 |
| Sachdev AmitEVP Chief Patient & Ext Af Off | Jun 5, 2024 | Jun 7, 2024 | G | 4,600 | $0.00 | $0 | not reported | No | Form 4 |
| Tatsis OuraniaEVP, Chief Reg. & Quality Off. | Jun 3, 2024 | Jun 5, 2024 | S | 2,175 | $460.00 | Sale −$1,000,500 | 49,098 | Yes | Form 4 |
| Wagner Charles F JrEVP & Chief Financial Officer | Jun 3, 2024 | Jun 5, 2024 | S | 3,250 | $460.00 | Sale −$1,495,000 | 47,137 | Yes | Form 4 |
| Tatsis OuraniaEVP, Chief Reg. & Quality Off. | May 31, 2024 | Jun 3, 2024 | S | 2,250 | $445.00 | Sale −$1,001,250 | 51,273 | Yes | Form 4 |
| Tatsis OuraniaEVP, Chief Reg. & Quality Off. | May 30, 2024 | Jun 3, 2024 | S | 2,350 | $439.11 | Sale −$1,031,909 | 53,523 | Yes | Form 4 |
| Bozic CarmenEVP and CMO | May 29, 2024 | May 31, 2024 | S | 2,280 | $445.56 | Sale −$1,015,877 | 34,659 | Yes | Form 4 |
| Wagner Charles F JrEVP & Chief Financial Officer | May 28, 2024 | May 30, 2024 | S | 3,250 | $454.79 | Sale −$1,478,068 | 50,387 | Yes | Form 4 |
| Kewalramani ReshmaCEO & President | May 24, 2024 | May 29, 2024 | M | 1,565 | $187.53 | $293,484 | 122,939 | Yes | Form 4 |
| Kewalramani ReshmaCEO & President | May 24, 2024 | May 29, 2024 | S | 1,565 | $457.00 | Sale −$715,205 | 121,374 | Yes | Form 4 |
| Kewalramani ReshmaCEO & President | May 24, 2024 | May 29, 2024 | M · derivative | 1,565 | $187.53 | $293,484 | not reported | Yes | Form 4 |
| Sachs Bruce I | May 22, 2024 | May 24, 2024 | M | 7,073 | $93.51 | $661,396 | 47,073 | Yes | Form 4 |
| Sachs Bruce I | May 22, 2024 | May 24, 2024 | S | 7,073 | $448.00 | Sale −$3,168,704 | 40,000 | Yes | Form 4 |
| Sachs Bruce I | May 22, 2024 | May 24, 2024 | M · derivative | 7,073 | $93.51 | $661,396 | not reported | Yes | Form 4 |
| Kewalramani ReshmaCEO & President | May 20, 2024 | May 22, 2024 | S | 15,202 | $447.00 | Sale −$6,795,294 | 121,374 | Yes | Form 4 |
| Schneider Jennifer | May 15, 2024 | May 17, 2024 | A | 922 | $0.00 | $0 | 922 | No | Form 4 |
| Altshuler DavidEVP, Chief Scientific Officer | May 15, 2024 | May 17, 2024 | S | 54 | $430.93 | Sale −$23,270 | 25,813 | Yes | Form 4 |
| Arbuckle Stuart AEVP, COO | May 15, 2024 | May 17, 2024 | S | 69 | $430.93 | Sale −$29,734 | 49,691 | Yes | Form 4 |
| Sachdev AmitEVP Chief Patient & Ext Af Off | May 15, 2024 | May 17, 2024 | S | 32 | $430.93 | Sale −$13,790 | 55,325 | Yes | Form 4 |
| Atkinson Edward Morrow IIIEVP, Chief Technical Ops. Off. | May 14, 2024 | May 16, 2024 | A | 14,112 | $0.00 | $0 | 30,084 | No | Form 4 |
| Bhatia Sangeeta N. | May 2, 2024 | May 3, 2024 | S | 467 | $402.95 | Sale −$188,178 | 4,435 | Yes | Form 4 |
| Bhatia Sangeeta N. | May 1, 2024 | May 3, 2024 | A | 1,001 | $0.00 | $0 | 4,902 | Yes | Form 4 |
| Carney Lloyd | May 1, 2024 | May 3, 2024 | A | 1,001 | $0.00 | $0 | 6,319 | No | Form 4 |
| Garber Alan M | May 1, 2024 | May 3, 2024 | A · derivative | 3,142 | $399.71 | $1,255,889 | 3,142 | No | Form 4 |
| Kearney Terrence C | May 1, 2024 | May 3, 2024 | A · derivative | 3,142 | $399.71 | $1,255,889 | 3,142 | No | Form 4 |
| Lagarde Michel | May 1, 2024 | May 3, 2024 | A · derivative | 3,142 | $399.71 | $1,255,889 | 3,142 | No | Form 4 |
| Mckenzie Diana | May 1, 2024 | May 3, 2024 | A | 1,001 | $0.00 | $0 | 3,604 | No | Form 4 |
| Mckenzie Diana | May 1, 2024 | May 3, 2024 | D | 1,168 | not reported | not reported | 2,436 | No | Form 4 |
| Mckenzie Diana | May 1, 2024 | May 3, 2024 | A · derivative | 1,168 | not reported | not reported | 5,990.48 | No | Form 4 |
| Sachs Bruce I | May 1, 2024 | May 3, 2024 | A · derivative | 3,142 | $399.71 | $1,255,889 | 3,142 | No | Form 4 |
| Thornberry Nancy | May 1, 2024 | May 3, 2024 | A | 501 | $0.00 | $0 | 1,637 | No | Form 4 |
| Thornberry Nancy | May 1, 2024 | May 3, 2024 | A · derivative | 1,571 | $399.71 | $627,944 | 1,571 | No | Form 4 |
| Upadhyay Suketu | May 1, 2024 | May 3, 2024 | A | 1,001 | $0.00 | $0 | 3,727 | No | Form 4 |
| Upadhyay Suketu | May 1, 2024 | May 3, 2024 | D | 1,168 | not reported | not reported | 2,559 | No | Form 4 |
| Upadhyay Suketu | May 1, 2024 | May 3, 2024 | A · derivative | 1,168 | not reported | not reported | 1,403 | No | Form 4 |
| Sachs Bruce I | Apr 15, 2024 | Apr 17, 2024 | A · derivative | 109.49 | $399.58 | $43,750 | 14,853.75 | No | Form 4 |
| Ambrose KristenSVP & Chief Accounting Officer | Apr 2, 2024 | Apr 3, 2024 | S | 240 | $419.00 | Sale −$100,560 | 7,500 | Yes | Form 4 |
| Ambrose KristenSVP & Chief Accounting Officer | Apr 1, 2024 | Apr 3, 2024 | F | 225 | $418.10 | $94,073 | 7,740 | Yes | Form 4 |
| Altshuler DavidEVP, Global Research and CSO | Feb 26, 2024 | Feb 27, 2024 | S | 4,239 | $425.70 | Sale −$1,804,542 | 25,813 | Yes | Form 4 |
| Ambrose KristenSVP & Chief Accounting Officer | Feb 26, 2024 | Feb 27, 2024 | S | 883 | $425.70 | Sale −$375,893 | 7,965 | Yes | Form 4 |
| Arbuckle Stuart AEVP, COO | Feb 26, 2024 | Feb 27, 2024 | S | 5,034 | $425.70 | Sale −$2,142,974 | 49,691 | Yes | Form 4 |
| Atkinson Edward Morrow IIIEVP, Chief Technical Ops. Off. | Feb 26, 2024 | Feb 27, 2024 | S | 883 | $425.70 | Sale −$375,893 | 15,972 | Yes | Form 4 |
| Sachdev AmitEVP Chief Patient & Ext Af Off | Feb 26, 2024 | Feb 27, 2024 | S | 3,004 | $425.70 | Sale −$1,278,803 | 55,325 | Yes | Form 4 |
| Tatsis OuraniaEVP, Chief Reg. & Quality Off. | Feb 26, 2024 | Feb 27, 2024 | S | 354 | $425.70 | Sale −$150,698 | 55,804 | Yes | Form 4 |
| Altshuler DavidEVP, Global Research and CSO | Feb 23, 2024 | Feb 27, 2024 | F | 3,970 | $431.79 | $1,714,206 | 30,052 | Yes | Form 4 |
| Ambrose KristenSVP & Chief Accounting Officer | Feb 23, 2024 | Feb 27, 2024 | F | 828 | $431.79 | $357,522 | 8,848 | Yes | Form 4 |
| Arbuckle Stuart AEVP, COO | Feb 23, 2024 | Feb 27, 2024 | F | 4,714 | $431.79 | $2,035,458 | 54,725 | Yes | Form 4 |
| Atkinson Edward Morrow IIIEVP, Chief Technical Ops. Off. | Feb 23, 2024 | Feb 27, 2024 | F | 1,654 | $431.79 | $714,181 | 16,855 | Yes | Form 4 |
| Bozic CarmenEVP and CMO | Feb 23, 2024 | Feb 27, 2024 | F | 3,309 | $431.79 | $1,428,793 | 36,939 | No | Form 4 |
| Kewalramani ReshmaCEO & President | Feb 23, 2024 | Feb 27, 2024 | F | 9,386 | $431.79 | $4,052,781 | 136,507 | No | Form 4 |
| Sachdev AmitEVP Chief Patient & Ext Af Off | Feb 23, 2024 | Feb 27, 2024 | F | 2,469 | $431.79 | $1,066,090 | 58,329 | Yes | Form 4 |
| Tatsis OuraniaEVP, Chief Reg. & Quality Off. | Feb 23, 2024 | Feb 27, 2024 | F | 3,309 | $431.79 | $1,428,793 | 56,158 | Yes | Form 4 |
| Wagner Charles F JrEVP & Chief Financial Officer | Feb 23, 2024 | Feb 27, 2024 | F | 3,309 | $431.79 | $1,428,793 | 53,583 | No | Form 4 |
| Altshuler DavidEVP, Global Research and CSO | Feb 21, 2024 | Feb 23, 2024 | S | 3,002 | $421.77 | Sale −$1,266,154 | 34,022 | Yes | Form 4 |
| Arbuckle Stuart AEVP, COO | Feb 21, 2024 | Feb 23, 2024 | S | 3,603 | $421.77 | Sale −$1,519,637 | 59,439 | Yes | Form 4 |
| Atkinson Edward Morrow IIIEVP, Chief Technical Ops. Off. | Feb 21, 2024 | Feb 23, 2024 | S | 1,201 | $421.77 | Sale −$506,546 | 18,509 | Yes | Form 4 |
| Sachdev AmitEVP Chief Patient & Ext Af Off | Feb 21, 2024 | Feb 23, 2024 | S | 3,191 | $421.77 | Sale −$1,345,868 | 60,798 | Yes | Form 4 |
| Tatsis OuraniaEVP, Chief Reg. & Quality Off. | Feb 21, 2024 | Feb 23, 2024 | S | 360 | $421.77 | Sale −$151,837 | 59,467 | Yes | Form 4 |
| Altshuler DavidEVP, Global Research and CSO | Feb 20, 2024 | Feb 21, 2024 | F | 2,812 | $420.58 | $1,182,671 | 41,026 | Yes | Form 4 |
| Altshuler DavidEVP, Global Research and CSO | Feb 20, 2024 | Feb 21, 2024 | S | 4,002 | $420.79 | Sale −$1,684,002 | 37,024 | Yes | Form 4 |
| Arbuckle Stuart AEVP, COO | Feb 20, 2024 | Feb 21, 2024 | F | 3,373 | $420.58 | $1,418,616 | 67,846 | Yes | Form 4 |
| Arbuckle Stuart AEVP, COO | Feb 20, 2024 | Feb 21, 2024 | S | 4,804 | $420.79 | Sale −$2,021,475 | 63,042 | Yes | Form 4 |
| Atkinson Edward Morrow IIIEVP, Chief Technical Ops. Off. | Feb 20, 2024 | Feb 21, 2024 | F | 1,125 | $420.58 | $473,153 | 20,511 | Yes | Form 4 |
| Atkinson Edward Morrow IIIEVP, Chief Technical Ops. Off. | Feb 20, 2024 | Feb 21, 2024 | S | 801 | $420.79 | Sale −$337,053 | 19,710 | Yes | Form 4 |
| Bozic CarmenEVP and CMO | Feb 20, 2024 | Feb 21, 2024 | F | 2,812 | $420.58 | $1,182,671 | 40,248 | No | Form 4 |
| Kewalramani ReshmaCEO & President | Feb 20, 2024 | Feb 21, 2024 | F | 7,019 | $420.58 | $2,952,051 | 145,893 | No | Form 4 |
| Leiden Jeffrey MExecutive Chairman | Feb 20, 2024 | Feb 21, 2024 | F | 4,118 | $420.58 | $1,731,948 | 13,778 | No | Form 4 |
| Sachdev AmitEVP Chief Patient & Ext Af Off | Feb 20, 2024 | Feb 21, 2024 | F | 2,623 | $420.58 | $1,103,181 | 68,243 | Yes | Form 4 |
| Sachdev AmitEVP Chief Patient & Ext Af Off | Feb 20, 2024 | Feb 21, 2024 | S | 4,254 | $420.79 | Sale −$1,790,041 | 63,989 | Yes | Form 4 |
| Tatsis OuraniaEVP, Chief Reg. & Quality Off. | Feb 20, 2024 | Feb 21, 2024 | F | 3,373 | $420.58 | $1,418,616 | 60,307 | Yes | Form 4 |
| Tatsis OuraniaEVP, Chief Reg. & Quality Off. | Feb 20, 2024 | Feb 21, 2024 | S | 480 | $420.79 | Sale −$201,979 | 59,827 | Yes | Form 4 |
| Wagner Charles F JrEVP & Chief Financial Officer | Feb 20, 2024 | Feb 21, 2024 | F | 2,812 | $420.58 | $1,182,671 | 56,892 | No | Form 4 |
| Altshuler DavidEVP, Global Research and CSO | Feb 16, 2024 | Feb 21, 2024 | F | 3,750 | $424.01 | $1,590,038 | 43,838 | Yes | Form 4 |
| Arbuckle Stuart AEVP, COO | Feb 16, 2024 | Feb 21, 2024 | F | 4,499 | $424.01 | $1,907,621 | 71,219 | Yes | Form 4 |
| Atkinson Edward Morrow IIIEVP, Chief Technical Ops. Off. | Feb 16, 2024 | Feb 21, 2024 | F | 1,501 | $424.01 | $636,439 | 21,636 | Yes | Form 4 |
| Bozic CarmenEVP and CMO | Feb 16, 2024 | Feb 21, 2024 | F | 3,750 | $424.01 | $1,590,038 | 43,060 | No | Form 4 |
| Kewalramani ReshmaCEO & President | Feb 16, 2024 | Feb 21, 2024 | F | 9,359 | $424.01 | $3,968,310 | 152,912 | No | Form 4 |
| Sachdev AmitEVP Chief Patient & Ext Af Off | Feb 16, 2024 | Feb 21, 2024 | F | 3,498 | $424.01 | $1,483,187 | 70,866 | Yes | Form 4 |
| Tatsis OuraniaEVP, Chief Reg. & Quality Off. | Feb 16, 2024 | Feb 21, 2024 | F | 4,499 | $424.01 | $1,907,621 | 63,680 | Yes | Form 4 |
| Wagner Charles F JrEVP & Chief Financial Officer | Feb 16, 2024 | Feb 21, 2024 | F | 3,750 | $424.01 | $1,590,038 | 59,704 | No | Form 4 |
| Leiden Jeffrey MExecutive Chairman | Feb 15, 2024 | Feb 16, 2024 | S | 4,655 | $419.16 | Sale −$1,951,190 | 17,896 | Yes | Form 4 |
| Leiden Jeffrey MExecutive Chairman | Feb 14, 2024 | Feb 16, 2024 | S | 4,356 | $419.04 | Sale −$1,825,338 | 22,551 | Yes | Form 4 |
| Leiden Jeffrey MExecutive Chairman | Feb 13, 2024 | Feb 14, 2024 | S | 737 | $419.13 | Sale −$308,899 | 26,907 | Yes | Form 4 |
| Leiden Jeffrey MExecutive Chairman | Feb 12, 2024 | Feb 14, 2024 | S | 2,009 | $419.22 | Sale −$842,213 | 28,291 | Yes | Form 4 |
| Leiden Jeffrey MExecutive Chairman | Feb 12, 2024 | Feb 14, 2024 | S | 647 | $420.39 | Sale −$271,992 | 27,644 | Yes | Form 4 |
| Altshuler DavidEVP, Global Research and CSO | Feb 12, 2024 | Feb 13, 2024 | S | 3,145 | $420.24 | Sale −$1,321,655 | 47,588 | Yes | Form 4 |
| Ambrose KristenSVP & Chief Accounting Officer | Feb 12, 2024 | Feb 13, 2024 | S | 1,374 | $420.24 | Sale −$577,410 | 9,676 | Yes | Form 4 |
| Arbuckle Stuart AEVP, COO | Feb 12, 2024 | Feb 13, 2024 | S | 4,295 | $420.24 | Sale −$1,804,931 | 75,718 | Yes | Form 4 |
| Atkinson Edward Morrow IIIEVP, Chief Technical Ops. Off. | Feb 12, 2024 | Feb 13, 2024 | S | 913 | $420.24 | Sale −$383,679 | 23,137 | Yes | Form 4 |
| Biller JonathanEVP and Chief Legal Officer | Feb 12, 2024 | Feb 13, 2024 | S | 1,738 | $418.77 | Sale −$727,822 | 18,280 | Yes | Form 4 |
| Sachdev AmitEVP Chief Patient & Ext Af Off | Feb 12, 2024 | Feb 13, 2024 | S | 3,222 | $420.24 | Sale −$1,354,013 | 74,364 | Yes | Form 4 |
| Tatsis OuraniaEVP, Chief Reg. & Quality Off. | Feb 12, 2024 | Feb 13, 2024 | S | 314 | $420.24 | Sale −$131,955 | 68,179 | Yes | Form 4 |
| Altshuler DavidEVP, Global Research and CSO | Feb 9, 2024 | Feb 13, 2024 | F | 2,099 | $422.74 | $887,331 | 50,733 | Yes | Form 4 |
| Ambrose KristenSVP & Chief Accounting Officer | Feb 9, 2024 | Feb 13, 2024 | F | 591 | $422.74 | $249,839 | 11,050 | Yes | Form 4 |
| Arbuckle Stuart AEVP, COO | Feb 9, 2024 | Feb 13, 2024 | F | 3,177 | $422.74 | $1,343,045 | 80,013 | Yes | Form 4 |
| Atkinson Edward Morrow IIIEVP, Chief Technical Ops. Off. | Feb 9, 2024 | Feb 13, 2024 | F | 832 | $422.74 | $351,720 | 24,050 | Yes | Form 4 |
| Biller JonathanEVP and Chief Legal Officer | Feb 9, 2024 | Feb 13, 2024 | F | 1,588 | $422.74 | $671,311 | 20,018 | Yes | Form 4 |
| Bozic CarmenEVP and CMO | Feb 9, 2024 | Feb 13, 2024 | F | 2,100 | $422.74 | $887,754 | 46,810 | No | Form 4 |
| Kewalramani ReshmaCEO & President | Feb 9, 2024 | Feb 13, 2024 | F | 8,255 | $422.74 | $3,489,719 | 162,271 | No | Form 4 |
| Sachdev AmitEVP Chief Patient & Ext Af Off | Feb 9, 2024 | Feb 13, 2024 | F | 2,022 | $422.74 | $854,780 | 77,586 | Yes | Form 4 |
| Tatsis OuraniaEVP, Chief Reg. & Quality Off. | Feb 9, 2024 | Feb 13, 2024 | F | 2,100 | $422.74 | $887,754 | 68,493 | Yes | Form 4 |
| Wagner Charles F JrEVP & Chief Financial Officer | Feb 9, 2024 | Feb 13, 2024 | F | 2,607 | $422.74 | $1,102,083 | 63,454 | No | Form 4 |
| Leiden Jeffrey MExecutive Chairman | Feb 9, 2024 | Feb 12, 2024 | F | 8,048 | $422.74 | $3,402,212 | 30,300 | No | Form 4 |
| Leiden Jeffrey MExecutive Chairman | Feb 8, 2024 | Feb 12, 2024 | F | 2,698 | $421.73 | $1,137,828 | 38,348 | No | Form 4 |
| Altshuler DavidEVP, Global Research and CSO | Feb 7, 2024 | Feb 8, 2024 | A | 7,114 | $0.00 | $0 | 52,832 | No | Form 4 |
| Ambrose KristenSVP & Chief Accounting Officer | Feb 7, 2024 | Feb 8, 2024 | A | 1,853 | $0.00 | $0 | 11,641 | No | Form 4 |
| Arbuckle Stuart AEVP, COO | Feb 7, 2024 | Feb 8, 2024 | A | 8,448 | $0.00 | $0 | 83,190 | No | Form 4 |
| Atkinson Edward Morrow IIIEVP, Chief Technical Ops. Off. | Feb 7, 2024 | Feb 8, 2024 | A | 4,743 | $0.00 | $0 | 24,882 | No | Form 4 |
| Biller JonathanEVP and Chief Legal Officer | Feb 7, 2024 | Feb 8, 2024 | A | 4,743 | $0.00 | $0 | 21,606 | No | Form 4 |
| Bozic CarmenEVP and CMO | Feb 7, 2024 | Feb 8, 2024 | A | 5,928 | $0.00 | $0 | 48,910 | No | Form 4 |
| Kewalramani ReshmaCEO & President | Feb 7, 2024 | Feb 8, 2024 | A | 20,327 | $0.00 | $0 | 170,526 | No | Form 4 |
| Leiden Jeffrey MExecutive Chairman | Feb 7, 2024 | Feb 8, 2024 | A | 7,707 | $0.00 | $0 | 41,046 | No | Form 4 |
| Sachdev AmitEVP Chief Patient & Ext Af Off | Feb 7, 2024 | Feb 8, 2024 | A | 7,114 | $0.00 | $0 | 79,608 | No | Form 4 |
| Tatsis OuraniaEVP, Chief Reg. & Quality Off. | Feb 7, 2024 | Feb 8, 2024 | A | 7,114 | $0.00 | $0 | 70,593 | No | Form 4 |
| Wagner Charles F JrEVP & Chief Financial Officer | Feb 7, 2024 | Feb 8, 2024 | A | 7,114 | $0.00 | $0 | 66,061 | No | Form 4 |
| Altshuler DavidEVP, Global Research and CSO | Feb 6, 2024 | Feb 8, 2024 | A | 5,814 | $0.00 | $0 | 37,852 | No | Form 4 |
| Altshuler DavidEVP, Global Research and CSO | Feb 6, 2024 | Feb 8, 2024 | A | 7,866 | $0.00 | $0 | 45,718 | No | Form 4 |
| Ambrose KristenSVP & Chief Accounting Officer | Feb 6, 2024 | Feb 8, 2024 | A | 2,950 | $0.00 | $0 | 9,788 | No | Form 4 |
| Arbuckle Stuart AEVP, COO | Feb 6, 2024 | Feb 8, 2024 | A | 6,976 | $0.00 | $0 | 63,532 | No | Form 4 |
| Arbuckle Stuart AEVP, COO | Feb 6, 2024 | Feb 8, 2024 | A | 11,210 | $0.00 | $0 | 74,742 | No | Form 4 |
| Atkinson Edward Morrow IIIEVP, Chief Technical Ops. Off. | Feb 6, 2024 | Feb 8, 2024 | A | 2,326 | $0.00 | $0 | 16,205 | No | Form 4 |
| Atkinson Edward Morrow IIIEVP, Chief Technical Ops. Off. | Feb 6, 2024 | Feb 8, 2024 | A | 3,934 | $0.00 | $0 | 20,139 | No | Form 4 |
| Biller JonathanEVP and Chief Legal Officer | Feb 6, 2024 | Feb 8, 2024 | A | 6,294 | $0.00 | $0 | 16,863 | No | Form 4 |
| Bozic CarmenEVP and CMO | Feb 6, 2024 | Feb 8, 2024 | A | 5,814 | $0.00 | $0 | 35,116 | No | Form 4 |
| Bozic CarmenEVP and CMO | Feb 6, 2024 | Feb 8, 2024 | A | 7,866 | $0.00 | $0 | 42,982 | No | Form 4 |
| Kewalramani ReshmaCEO & President | Feb 6, 2024 | Feb 8, 2024 | A | 14,516 | $0.00 | $0 | 123,227 | No | Form 4 |
| Kewalramani ReshmaCEO & President | Feb 6, 2024 | Feb 8, 2024 | A | 26,972 | $0.00 | $0 | 150,199 | No | Form 4 |
| Leiden Jeffrey MExecutive Chairman | Feb 6, 2024 | Feb 8, 2024 | A | 10,464 | $0.00 | $0 | 12,887 | No | Form 4 |
| Leiden Jeffrey MExecutive Chairman | Feb 6, 2024 | Feb 8, 2024 | A | 20,452 | $0.00 | $0 | 33,339 | No | Form 4 |
| Sachdev AmitEVP Chief Patient & Ext Af Off | Feb 6, 2024 | Feb 8, 2024 | A | 5,814 | $0.00 | $0 | 64,628 | No | Form 4 |
| Sachdev AmitEVP Chief Patient & Ext Af Off | Feb 6, 2024 | Feb 8, 2024 | A | 7,866 | $0.00 | $0 | 72,494 | No | Form 4 |